---
_id: '8740'
abstract:
- lang: eng
  text: In vitro work revealed that excitatory synaptic inputs to hippocampal inhibitory
    interneurons could undergo Hebbian, associative, or non-associative plasticity.
    Both behavioral and learning-dependent reorganization of these connections has
    also been demonstrated by measuring spike transmission probabilities in pyramidal
    cell-interneuron spike cross-correlations that indicate monosynaptic connections.
    Here we investigated the activity-dependent modification of these connections
    during exploratory behavior in rats by optogenetically inhibiting pyramidal cell
    and interneuron subpopulations. Light application and associated firing alteration
    of pyramidal and interneuron populations led to lasting changes in pyramidal-interneuron
    connection weights as indicated by spike transmission changes. Spike transmission
    alterations were predicted by the light-mediated changes in the number of pre-
    and postsynaptic spike pairing events and by firing rate changes of interneurons
    but not pyramidal cells. This work demonstrates the presence of activity-dependent
    associative and non-associative reorganization of pyramidal-interneuron connections
    triggered by the optogenetic modification of the firing rate and spike synchrony
    of cells.
acknowledgement: We thank Michele Nardin and Federico Stella for comments on an earlier
  version of the manuscript. K Deisseroth for providing the pAAV-CaMKIIα::eNpHR3.0-YFP
  plasmid through Addgene. E Boyden for providing AAV2/1.CaMKII::ArchT.GFP.WPRE.SV40
  plasmid through Penn Vector Core. This work was supported by the Austrian Science
  Fund (I02072 and I03713) and a Swiss National Science Foundation grant to PS. The
  authors declare no conflicts of interest.
article_number: '61106'
article_processing_charge: No
article_type: original
author:
- first_name: Igor
  full_name: Gridchyn, Igor
  id: 4B60654C-F248-11E8-B48F-1D18A9856A87
  last_name: Gridchyn
  orcid: 0000-0002-1807-1929
- first_name: Philipp
  full_name: Schönenberger, Philipp
  id: 3B9D816C-F248-11E8-B48F-1D18A9856A87
  last_name: Schönenberger
- first_name: Joseph
  full_name: O'Neill, Joseph
  id: 426376DC-F248-11E8-B48F-1D18A9856A87
  last_name: O'Neill
- first_name: Jozsef L
  full_name: Csicsvari, Jozsef L
  id: 3FA14672-F248-11E8-B48F-1D18A9856A87
  last_name: Csicsvari
  orcid: 0000-0002-5193-4036
citation:
  ama: Gridchyn I, Schönenberger P, O’Neill J, Csicsvari JL. Optogenetic inhibition-mediated
    activity-dependent modification of CA1 pyramidal-interneuron connections during
    behavior. <i>eLife</i>. 2020;9. doi:<a href="https://doi.org/10.7554/eLife.61106">10.7554/eLife.61106</a>
  apa: Gridchyn, I., Schönenberger, P., O’Neill, J., &#38; Csicsvari, J. L. (2020).
    Optogenetic inhibition-mediated activity-dependent modification of CA1 pyramidal-interneuron
    connections during behavior. <i>ELife</i>. eLife Sciences Publications. <a href="https://doi.org/10.7554/eLife.61106">https://doi.org/10.7554/eLife.61106</a>
  chicago: Gridchyn, Igor, Philipp Schönenberger, Joseph O’Neill, and Jozsef L Csicsvari.
    “Optogenetic Inhibition-Mediated Activity-Dependent Modification of CA1 Pyramidal-Interneuron
    Connections during Behavior.” <i>ELife</i>. eLife Sciences Publications, 2020.
    <a href="https://doi.org/10.7554/eLife.61106">https://doi.org/10.7554/eLife.61106</a>.
  ieee: I. Gridchyn, P. Schönenberger, J. O’Neill, and J. L. Csicsvari, “Optogenetic
    inhibition-mediated activity-dependent modification of CA1 pyramidal-interneuron
    connections during behavior,” <i>eLife</i>, vol. 9. eLife Sciences Publications,
    2020.
  ista: Gridchyn I, Schönenberger P, O’Neill J, Csicsvari JL. 2020. Optogenetic inhibition-mediated
    activity-dependent modification of CA1 pyramidal-interneuron connections during
    behavior. eLife. 9, 61106.
  mla: Gridchyn, Igor, et al. “Optogenetic Inhibition-Mediated Activity-Dependent
    Modification of CA1 Pyramidal-Interneuron Connections during Behavior.” <i>ELife</i>,
    vol. 9, 61106, eLife Sciences Publications, 2020, doi:<a href="https://doi.org/10.7554/eLife.61106">10.7554/eLife.61106</a>.
  short: I. Gridchyn, P. Schönenberger, J. O’Neill, J.L. Csicsvari, ELife 9 (2020).
date_created: 2020-11-08T23:01:25Z
date_published: 2020-10-05T00:00:00Z
date_updated: 2024-02-21T12:43:40Z
day: '05'
ddc:
- '570'
department:
- _id: JoCs
doi: 10.7554/eLife.61106
external_id:
  isi:
  - '000584369000001'
file:
- access_level: open_access
  checksum: 6a7b0543c440f4c000a1864e69377d95
  content_type: application/pdf
  creator: dernst
  date_created: 2020-11-09T09:17:40Z
  date_updated: 2020-11-09T09:17:40Z
  file_id: '8749'
  file_name: 2020_eLife_Gridchyn.pdf
  file_size: 447669
  relation: main_file
  success: 1
file_date_updated: 2020-11-09T09:17:40Z
has_accepted_license: '1'
intvolume: '         9'
isi: 1
language:
- iso: eng
license: https://creativecommons.org/licenses/by/4.0/
month: '10'
oa: 1
oa_version: Published Version
project:
- _id: 257D4372-B435-11E9-9278-68D0E5697425
  call_identifier: FWF
  grant_number: I2072-B27
  name: Interneuron plasticity during spatial learning
- _id: 2654F984-B435-11E9-9278-68D0E5697425
  call_identifier: FWF
  grant_number: I03713
  name: Interneuro Plasticity During Spatial Learning
publication: eLife
publication_identifier:
  eissn:
  - 2050084X
publication_status: published
publisher: eLife Sciences Publications
quality_controlled: '1'
related_material:
  record:
  - id: '8563'
    relation: research_data
    status: public
scopus_import: '1'
status: public
title: Optogenetic inhibition-mediated activity-dependent modification of CA1 pyramidal-interneuron
  connections during behavior
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 9
year: '2020'
...
---
_id: '6338'
abstract:
- lang: eng
  text: Hippocampal activity patterns representing movement trajectories are reactivated
    in immobility and sleep periods, a process associated with memory recall, consolidation,
    and decision making. It is thought that only fixed, behaviorally relevant patterns
    can be reactivated, which are stored across hippocampal synaptic connections.
    To test whether some generalized rules govern reactivation, we examined trajectory
    reactivation following non-stereotypical exploration of familiar open-field environments.
    We found that random trajectories of varying lengths and timescales were reactivated,
    resembling that of Brownian motion of particles. The animals’ behavioral trajectory
    did not follow Brownian diffusion demonstrating that the exact behavioral experience
    is not reactivated. Therefore, hippocampal circuits are able to generate random
    trajectories of any recently active map by following diffusion dynamics. This
    ability of hippocampal circuits to generate representations of all behavioral
    outcome combinations, experienced or not, may underlie a wide variety of hippocampal-dependent
    cognitive functions such as learning, generalization, and planning.
article_processing_charge: No
article_type: original
author:
- first_name: Federico
  full_name: Stella, Federico
  id: 39AF1E74-F248-11E8-B48F-1D18A9856A87
  last_name: Stella
  orcid: 0000-0001-9439-3148
- first_name: Peter
  full_name: Baracskay, Peter
  id: 361CC00E-F248-11E8-B48F-1D18A9856A87
  last_name: Baracskay
- first_name: Joseph
  full_name: O'Neill, Joseph
  id: 426376DC-F248-11E8-B48F-1D18A9856A87
  last_name: O'Neill
- first_name: Jozsef L
  full_name: Csicsvari, Jozsef L
  id: 3FA14672-F248-11E8-B48F-1D18A9856A87
  last_name: Csicsvari
  orcid: 0000-0002-5193-4036
citation:
  ama: Stella F, Baracskay P, O’Neill J, Csicsvari JL. Hippocampal reactivation of
    random trajectories resembling Brownian diffusion. <i>Neuron</i>. 2019;102:450-461.
    doi:<a href="https://doi.org/10.1016/j.neuron.2019.01.052">10.1016/j.neuron.2019.01.052</a>
  apa: Stella, F., Baracskay, P., O’Neill, J., &#38; Csicsvari, J. L. (2019). Hippocampal
    reactivation of random trajectories resembling Brownian diffusion. <i>Neuron</i>.
    Elsevier. <a href="https://doi.org/10.1016/j.neuron.2019.01.052">https://doi.org/10.1016/j.neuron.2019.01.052</a>
  chicago: Stella, Federico, Peter Baracskay, Joseph O’Neill, and Jozsef L Csicsvari.
    “Hippocampal Reactivation of Random Trajectories Resembling Brownian Diffusion.”
    <i>Neuron</i>. Elsevier, 2019. <a href="https://doi.org/10.1016/j.neuron.2019.01.052">https://doi.org/10.1016/j.neuron.2019.01.052</a>.
  ieee: F. Stella, P. Baracskay, J. O’Neill, and J. L. Csicsvari, “Hippocampal reactivation
    of random trajectories resembling Brownian diffusion,” <i>Neuron</i>, vol. 102.
    Elsevier, pp. 450–461, 2019.
  ista: Stella F, Baracskay P, O’Neill J, Csicsvari JL. 2019. Hippocampal reactivation
    of random trajectories resembling Brownian diffusion. Neuron. 102, 450–461.
  mla: Stella, Federico, et al. “Hippocampal Reactivation of Random Trajectories Resembling
    Brownian Diffusion.” <i>Neuron</i>, vol. 102, Elsevier, 2019, pp. 450–61, doi:<a
    href="https://doi.org/10.1016/j.neuron.2019.01.052">10.1016/j.neuron.2019.01.052</a>.
  short: F. Stella, P. Baracskay, J. O’Neill, J.L. Csicsvari, Neuron 102 (2019) 450–461.
date_created: 2019-04-17T08:28:59Z
date_published: 2019-04-17T00:00:00Z
date_updated: 2023-08-25T10:13:07Z
day: '17'
department:
- _id: JoCs
doi: 10.1016/j.neuron.2019.01.052
ec_funded: 1
external_id:
  isi:
  - '000465169700017'
  pmid:
  - '30819547'
intvolume: '       102'
isi: 1
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://doi.org/10.1016/j.neuron.2019.01.052
month: '04'
oa: 1
oa_version: Published Version
page: 450-461
pmid: 1
project:
- _id: 257A4776-B435-11E9-9278-68D0E5697425
  call_identifier: FP7
  grant_number: '281511'
  name: Memory-related information processing in neuronal circuits of the hippocampus
    and entorhinal cortex
- _id: 2654F984-B435-11E9-9278-68D0E5697425
  call_identifier: FWF
  grant_number: I03713
  name: Interneuro Plasticity During Spatial Learning
publication: Neuron
publication_status: published
publisher: Elsevier
quality_controlled: '1'
related_material:
  link:
  - description: News on IST Homepage
    relation: press_release
    url: https://ist.ac.at/en/news/memories-of-movement-are-replayed-randomly-during-sleep/
scopus_import: '1'
status: public
title: Hippocampal reactivation of random trajectories resembling Brownian diffusion
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 102
year: '2019'
...