---
_id: '7227'
abstract:
- lang: eng
  text: Gastrulation entails specification and formation of three embryonic germ layers—ectoderm,
    mesoderm and endoderm—thereby establishing the basis for the future body plan.
    In zebrafish embryos, germ layer specification occurs during blastula and early
    gastrula stages (Ho & Kimmel, 1993), a period when the main morphogenetic movements
    underlying gastrulation are initiated. Hence, the signals driving progenitor cell
    fate specification, such as Nodal ligands from the TGF-β family, also play key
    roles in regulating germ layer progenitor cell segregation (Carmany-Rampey & Schier,
    2001; David & Rosa, 2001; Feldman et al., 2000; Gritsman et al., 1999; Keller
    et al., 2008). In this review, we summarize and discuss the main signaling pathways
    involved in germ layer progenitor cell fate specification and segregation, specifically
    focusing on recent advances in understanding the interplay between mesoderm and
    endoderm specification and the internalization movements at the onset of zebrafish
    gastrulation.
acknowledgement: We thank Alexandra Schauer, Nicoletta Petridou and Feyza Nur Arslan
  for comments on the manuscript. Research in the Heisenberg laboratory is supported
  by an ERC Advanced Grant (MECSPEC 742573), ANR/FWF (I03601) and FWF/DFG (I03196)
  International Cooperation Grants. D. Pinheiro acknowledges a fellowship from EMBO
  ALTF (850-2017) and is currently supported by HFSP LTF (LT000429/2018-L2).
alternative_title:
- Current Topics in Developmental Biology
article_processing_charge: No
author:
- first_name: Diana C
  full_name: Nunes Pinheiro, Diana C
  id: 2E839F16-F248-11E8-B48F-1D18A9856A87
  last_name: Nunes Pinheiro
  orcid: 0000-0003-4333-7503
- first_name: Carl-Philipp J
  full_name: Heisenberg, Carl-Philipp J
  id: 39427864-F248-11E8-B48F-1D18A9856A87
  last_name: Heisenberg
  orcid: 0000-0002-0912-4566
citation:
  ama: 'Nunes Pinheiro DC, Heisenberg C-PJ. Zebrafish gastrulation: Putting fate in
    motion. In: <i>Gastrulation: From Embryonic Pattern to Form</i>. Vol 136. Elsevier;
    2020:343-375. doi:<a href="https://doi.org/10.1016/bs.ctdb.2019.10.009">10.1016/bs.ctdb.2019.10.009</a>'
  apa: 'Nunes Pinheiro, D. C., &#38; Heisenberg, C.-P. J. (2020). Zebrafish gastrulation:
    Putting fate in motion. In <i>Gastrulation: From Embryonic Pattern to Form</i>
    (Vol. 136, pp. 343–375). Elsevier. <a href="https://doi.org/10.1016/bs.ctdb.2019.10.009">https://doi.org/10.1016/bs.ctdb.2019.10.009</a>'
  chicago: 'Nunes Pinheiro, Diana C, and Carl-Philipp J Heisenberg. “Zebrafish Gastrulation:
    Putting Fate in Motion.” In <i>Gastrulation: From Embryonic Pattern to Form</i>,
    136:343–75. Elsevier, 2020. <a href="https://doi.org/10.1016/bs.ctdb.2019.10.009">https://doi.org/10.1016/bs.ctdb.2019.10.009</a>.'
  ieee: 'D. C. Nunes Pinheiro and C.-P. J. Heisenberg, “Zebrafish gastrulation: Putting
    fate in motion,” in <i>Gastrulation: From Embryonic Pattern to Form</i>, vol.
    136, Elsevier, 2020, pp. 343–375.'
  ista: 'Nunes Pinheiro DC, Heisenberg C-PJ. 2020.Zebrafish gastrulation: Putting
    fate in motion. In: Gastrulation: From Embryonic Pattern to Form. Current Topics
    in Developmental Biology, vol. 136, 343–375.'
  mla: 'Nunes Pinheiro, Diana C., and Carl-Philipp J. Heisenberg. “Zebrafish Gastrulation:
    Putting Fate in Motion.” <i>Gastrulation: From Embryonic Pattern to Form</i>,
    vol. 136, Elsevier, 2020, pp. 343–75, doi:<a href="https://doi.org/10.1016/bs.ctdb.2019.10.009">10.1016/bs.ctdb.2019.10.009</a>.'
  short: 'D.C. Nunes Pinheiro, C.-P.J. Heisenberg, in:, Gastrulation: From Embryonic
    Pattern to Form, Elsevier, 2020, pp. 343–375.'
date_created: 2020-01-05T23:00:46Z
date_published: 2020-06-01T00:00:00Z
date_updated: 2023-09-06T14:54:36Z
day: '01'
department:
- _id: CaHe
doi: 10.1016/bs.ctdb.2019.10.009
ec_funded: 1
external_id:
  isi:
  - '000611830600013'
  pmid:
  - '31959295'
intvolume: '       136'
isi: 1
language:
- iso: eng
month: '06'
oa_version: None
page: 343-375
pmid: 1
project:
- _id: 260F1432-B435-11E9-9278-68D0E5697425
  call_identifier: H2020
  grant_number: '742573'
  name: Interaction and feedback between cell mechanics and fate specification in
    vertebrate gastrulation
- _id: 2646861A-B435-11E9-9278-68D0E5697425
  call_identifier: FWF
  grant_number: I03601
  name: Control of embryonic cleavage pattern
- _id: 2608FC64-B435-11E9-9278-68D0E5697425
  call_identifier: FWF
  grant_number: I03196
  name: Control of epithelial cell layer spreading in zebrafish
- _id: 266BC5CE-B435-11E9-9278-68D0E5697425
  grant_number: LT000429
  name: Coordination of mesendoderm fate specification and internalization during
    zebrafish gastrulation
- _id: 26520D1E-B435-11E9-9278-68D0E5697425
  grant_number: ALTF 850-2017
  name: Coordination of mesendoderm cell fate specification and internalization during
    zebrafish gastrulation
publication: 'Gastrulation: From Embryonic Pattern to Form'
publication_identifier:
  issn:
  - '00702153'
publication_status: published
publisher: Elsevier
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Zebrafish gastrulation: Putting fate in motion'
type: book_chapter
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 136
year: '2020'
...