---
_id: '320'
abstract:
- lang: eng
  text: 'Fast-spiking, parvalbumin-expressing GABAergic interneurons (PV+-BCs) express
    a complex machinery of rapid signaling mechanisms, including specialized voltage-gated
    ion channels to generate brief action potentials (APs). However, short APs are
    associated with overlapping Na+ and K+ fluxes and are therefore energetically
    expensive. How the potentially vicious combination of high AP frequency and inefficient
    spike generation can be reconciled with limited energy supply is presently unclear.
    To address this question, we performed direct recordings from the PV+-BC axon,
    the subcellular structure where active conductances for AP initiation and propagation
    are located. Surprisingly, the energy required for the AP was, on average, only
    ∼1.6 times the theoretical minimum. High energy efficiency emerged from the combination
    of fast inactivation of Na+ channels and delayed activation of Kv3-type K+ channels,
    which minimized ion flux overlap during APs. Thus, the complementary tuning of
    axonal Na+ and K+ channel gating optimizes both fast signaling properties and
    metabolic efficiency. Hu et al. demonstrate that action potentials in parvalbumin-expressing
    GABAergic interneuron axons are energetically efficient, which is highly unexpected
    given their brief duration. High energy efficiency emerges from the combination
    of fast inactivation of voltage-gated Na+ channels and delayed activation of Kv3
    channels in the axon. '
article_processing_charge: Yes (in subscription journal)
author:
- first_name: Hua
  full_name: Hu, Hua
  id: 4AC0145C-F248-11E8-B48F-1D18A9856A87
  last_name: Hu
- first_name: Fabian
  full_name: Roth, Fabian
  last_name: Roth
- first_name: David H
  full_name: Vandael, David H
  id: 3AE48E0A-F248-11E8-B48F-1D18A9856A87
  last_name: Vandael
  orcid: 0000-0001-7577-1676
- first_name: Peter M
  full_name: Jonas, Peter M
  id: 353C1B58-F248-11E8-B48F-1D18A9856A87
  last_name: Jonas
  orcid: 0000-0001-5001-4804
citation:
  ama: Hu H, Roth F, Vandael DH, Jonas PM. Complementary tuning of Na+ and K+ channel
    gating underlies fast and energy-efficient action potentials in GABAergic interneuron
    axons. <i>Neuron</i>. 2018;98(1):156-165. doi:<a href="https://doi.org/10.1016/j.neuron.2018.02.024">10.1016/j.neuron.2018.02.024</a>
  apa: Hu, H., Roth, F., Vandael, D. H., &#38; Jonas, P. M. (2018). Complementary
    tuning of Na+ and K+ channel gating underlies fast and energy-efficient action
    potentials in GABAergic interneuron axons. <i>Neuron</i>. Elsevier. <a href="https://doi.org/10.1016/j.neuron.2018.02.024">https://doi.org/10.1016/j.neuron.2018.02.024</a>
  chicago: Hu, Hua, Fabian Roth, David H Vandael, and Peter M Jonas. “Complementary
    Tuning of Na+ and K+ Channel Gating Underlies Fast and Energy-Efficient Action
    Potentials in GABAergic Interneuron Axons.” <i>Neuron</i>. Elsevier, 2018. <a
    href="https://doi.org/10.1016/j.neuron.2018.02.024">https://doi.org/10.1016/j.neuron.2018.02.024</a>.
  ieee: H. Hu, F. Roth, D. H. Vandael, and P. M. Jonas, “Complementary tuning of Na+
    and K+ channel gating underlies fast and energy-efficient action potentials in
    GABAergic interneuron axons,” <i>Neuron</i>, vol. 98, no. 1. Elsevier, pp. 156–165,
    2018.
  ista: Hu H, Roth F, Vandael DH, Jonas PM. 2018. Complementary tuning of Na+ and
    K+ channel gating underlies fast and energy-efficient action potentials in GABAergic
    interneuron axons. Neuron. 98(1), 156–165.
  mla: Hu, Hua, et al. “Complementary Tuning of Na+ and K+ Channel Gating Underlies
    Fast and Energy-Efficient Action Potentials in GABAergic Interneuron Axons.” <i>Neuron</i>,
    vol. 98, no. 1, Elsevier, 2018, pp. 156–65, doi:<a href="https://doi.org/10.1016/j.neuron.2018.02.024">10.1016/j.neuron.2018.02.024</a>.
  short: H. Hu, F. Roth, D.H. Vandael, P.M. Jonas, Neuron 98 (2018) 156–165.
date_created: 2018-12-11T11:45:48Z
date_published: 2018-04-04T00:00:00Z
date_updated: 2023-09-11T12:45:10Z
day: '04'
ddc:
- '570'
department:
- _id: PeJo
doi: 10.1016/j.neuron.2018.02.024
ec_funded: 1
external_id:
  isi:
  - '000429192100016'
file:
- access_level: open_access
  checksum: 76070f3729f9c603e1080d0151aa2b11
  content_type: application/pdf
  creator: dernst
  date_created: 2018-12-17T10:37:50Z
  date_updated: 2020-07-14T12:46:03Z
  file_id: '5690'
  file_name: 2018_Neuron_Hu.pdf
  file_size: 3180444
  relation: main_file
file_date_updated: 2020-07-14T12:46:03Z
has_accepted_license: '1'
intvolume: '        98'
isi: 1
issue: '1'
language:
- iso: eng
month: '04'
oa: 1
oa_version: Published Version
page: 156 - 165
project:
- _id: 25C0F108-B435-11E9-9278-68D0E5697425
  call_identifier: FP7
  grant_number: '268548'
  name: Nanophysiology of fast-spiking, parvalbumin-expressing GABAergic interneurons
- _id: 25B7EB9E-B435-11E9-9278-68D0E5697425
  call_identifier: H2020
  grant_number: '692692'
  name: Biophysics and circuit function of a giant cortical glumatergic synapse
- _id: 25C26B1E-B435-11E9-9278-68D0E5697425
  call_identifier: FWF
  grant_number: P24909-B24
  name: Mechanisms of transmitter release at GABAergic synapses
- _id: 25C5A090-B435-11E9-9278-68D0E5697425
  call_identifier: FWF
  grant_number: Z00312
  name: The Wittgenstein Prize
publication: Neuron
publication_status: published
publisher: Elsevier
publist_id: '7545'
quality_controlled: '1'
related_material:
  link:
  - description: News on IST Homepage
    relation: press_release
    url: https://ist.ac.at/en/news/a-certain-type-of-neurons-is-more-energy-efficient-than-previously-assumed/
scopus_import: '1'
status: public
title: Complementary tuning of Na+ and K+ channel gating underlies fast and energy-efficient
  action potentials in GABAergic interneuron axons
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 98
year: '2018'
...
---
_id: '1117'
abstract:
- lang: eng
  text: 'GABAergic synapses in brain circuits generate inhibitory output signals with
    submillisecond latency and temporal precision. Whether the molecular identity
    of the release sensor contributes to these signaling properties remains unclear.
    Here, we examined the Ca^2+ sensor of exocytosis at GABAergic basket cell (BC)
    to Purkinje cell (PC) synapses in cerebellum. Immunolabeling suggested that BC
    terminals selectively expressed synaptotagmin 2 (Syt2), whereas synaptotagmin
    1 (Syt1) was enriched in excitatory terminals. Genetic elimination of Syt2 reduced
    action potential-evoked release to ∼10%, identifying Syt2 as the major Ca^2+ sensor
    at BC-PC synapses. Differential adenovirus-mediated rescue revealed that Syt2
    triggered release with shorter latency and higher temporal precision and mediated
    faster vesicle pool replenishment than Syt1. Furthermore, deletion of Syt2 severely
    reduced and delayed disynaptic inhibition following parallel fiber stimulation.
    Thus, the selective use of Syt2 as release sensor at BC-PC synapses ensures fast
    and efficient feedforward inhibition in cerebellar microcircuits. #bioimagingfacility-author'
acknowledged_ssus:
- _id: Bio
- _id: PreCl
article_processing_charge: No
author:
- first_name: Chong
  full_name: Chen, Chong
  id: 3DFD581A-F248-11E8-B48F-1D18A9856A87
  last_name: Chen
- first_name: Itaru
  full_name: Arai, Itaru
  id: 32A73F6C-F248-11E8-B48F-1D18A9856A87
  last_name: Arai
- first_name: Rachel
  full_name: Satterield, Rachel
  last_name: Satterield
- first_name: Samuel
  full_name: Young, Samuel
  last_name: Young
- first_name: Peter M
  full_name: Jonas, Peter M
  id: 353C1B58-F248-11E8-B48F-1D18A9856A87
  last_name: Jonas
  orcid: 0000-0001-5001-4804
citation:
  ama: Chen C, Arai  itaru, Satterield R, Young S, Jonas PM. Synaptotagmin 2 is the
    fast Ca2+ sensor at a central inhibitory synapse. <i>Cell Reports</i>. 2017;18(3):723-736.
    doi:<a href="https://doi.org/10.1016/j.celrep.2016.12.067">10.1016/j.celrep.2016.12.067</a>
  apa: Chen, C., Arai,  itaru, Satterield, R., Young, S., &#38; Jonas, P. M. (2017).
    Synaptotagmin 2 is the fast Ca2+ sensor at a central inhibitory synapse. <i>Cell
    Reports</i>. Cell Press. <a href="https://doi.org/10.1016/j.celrep.2016.12.067">https://doi.org/10.1016/j.celrep.2016.12.067</a>
  chicago: Chen, Chong, itaru Arai, Rachel Satterield, Samuel Young, and Peter M Jonas.
    “Synaptotagmin 2 Is the Fast Ca2+ Sensor at a Central Inhibitory Synapse.” <i>Cell
    Reports</i>. Cell Press, 2017. <a href="https://doi.org/10.1016/j.celrep.2016.12.067">https://doi.org/10.1016/j.celrep.2016.12.067</a>.
  ieee: C. Chen,  itaru Arai, R. Satterield, S. Young, and P. M. Jonas, “Synaptotagmin
    2 is the fast Ca2+ sensor at a central inhibitory synapse,” <i>Cell Reports</i>,
    vol. 18, no. 3. Cell Press, pp. 723–736, 2017.
  ista: Chen C, Arai  itaru, Satterield R, Young S, Jonas PM. 2017. Synaptotagmin
    2 is the fast Ca2+ sensor at a central inhibitory synapse. Cell Reports. 18(3),
    723–736.
  mla: Chen, Chong, et al. “Synaptotagmin 2 Is the Fast Ca2+ Sensor at a Central Inhibitory
    Synapse.” <i>Cell Reports</i>, vol. 18, no. 3, Cell Press, 2017, pp. 723–36, doi:<a
    href="https://doi.org/10.1016/j.celrep.2016.12.067">10.1016/j.celrep.2016.12.067</a>.
  short: C. Chen,  itaru Arai, R. Satterield, S. Young, P.M. Jonas, Cell Reports 18
    (2017) 723–736.
date_created: 2018-12-11T11:50:14Z
date_published: 2017-01-17T00:00:00Z
date_updated: 2023-09-20T11:32:15Z
day: '17'
ddc:
- '571'
department:
- _id: PeJo
doi: 10.1016/j.celrep.2016.12.067
ec_funded: 1
external_id:
  isi:
  - '000396470600013'
file:
- access_level: open_access
  content_type: application/pdf
  creator: system
  date_created: 2018-12-12T10:16:09Z
  date_updated: 2018-12-12T10:16:09Z
  file_id: '5195'
  file_name: IST-2017-751-v1+1_1-s2.0-S2211124716317740-main.pdf
  file_size: 4427591
  relation: main_file
file_date_updated: 2018-12-12T10:16:09Z
has_accepted_license: '1'
intvolume: '        18'
isi: 1
issue: '3'
language:
- iso: eng
month: '01'
oa: 1
oa_version: Published Version
page: 723 - 736
project:
- _id: 25C26B1E-B435-11E9-9278-68D0E5697425
  call_identifier: FWF
  grant_number: P24909-B24
  name: Mechanisms of transmitter release at GABAergic synapses
- _id: 25C0F108-B435-11E9-9278-68D0E5697425
  call_identifier: FP7
  grant_number: '268548'
  name: Nanophysiology of fast-spiking, parvalbumin-expressing GABAergic interneurons
publication: Cell Reports
publication_identifier:
  issn:
  - '22111247'
publication_status: published
publisher: Cell Press
publist_id: '6245'
pubrep_id: '751'
quality_controlled: '1'
related_material:
  record:
  - id: '324'
    relation: dissertation_contains
    status: public
scopus_import: '1'
status: public
title: Synaptotagmin 2 is the fast Ca2+ sensor at a central inhibitory synapse
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 18
year: '2017'
...
---
_id: '1118'
abstract:
- lang: eng
  text: Sharp wave-ripple (SWR) oscillations play a key role in memory consolidation
    during non-rapid eye movement sleep, immobility, and consummatory behavior. However,
    whether temporally modulated synaptic excitation or inhibition underlies the ripples
    is controversial. To address this question, we performed simultaneous recordings
    of excitatory and inhibitory postsynaptic currents (EPSCs and IPSCs) and local
    field potentials (LFPs) in the CA1 region of awake mice in vivo. During SWRs,
    inhibition dominated over excitation, with a peak conductance ratio of 4.1 ± 0.5.
    Furthermore, the amplitude of SWR-associated IPSCs was positively correlated with
    SWR magnitude, whereas that of EPSCs was not. Finally, phase analysis indicated
    that IPSCs were phase-locked to individual ripple cycles, whereas EPSCs were uniformly
    distributed in phase space. Optogenetic inhibition indicated that PV+ interneurons
    provided a major contribution to SWR-associated IPSCs. Thus, phasic inhibition,
    but not excitation, shapes SWR oscillations in the hippocampal CA1 region in vivo.
acknowledged_ssus:
- _id: M-Shop
- _id: ScienComp
- _id: PreCl
article_processing_charge: No
author:
- first_name: Jian
  full_name: Gan, Jian
  id: 3614E438-F248-11E8-B48F-1D18A9856A87
  last_name: Gan
- first_name: Shih-Ming
  full_name: Weng, Shih-Ming
  id: 2F9C5AC8-F248-11E8-B48F-1D18A9856A87
  last_name: Weng
- first_name: Alejandro
  full_name: Pernia-Andrade, Alejandro
  id: 36963E98-F248-11E8-B48F-1D18A9856A87
  last_name: Pernia-Andrade
- first_name: Jozsef L
  full_name: Csicsvari, Jozsef L
  id: 3FA14672-F248-11E8-B48F-1D18A9856A87
  last_name: Csicsvari
  orcid: 0000-0002-5193-4036
- first_name: Peter M
  full_name: Jonas, Peter M
  id: 353C1B58-F248-11E8-B48F-1D18A9856A87
  last_name: Jonas
  orcid: 0000-0001-5001-4804
citation:
  ama: Gan J, Weng S-M, Pernia-Andrade A, Csicsvari JL, Jonas PM. Phase-locked inhibition,
    but not excitation, underlies hippocampal ripple oscillations in awake mice in
    vivo. <i>Neuron</i>. 2017;93(2):308-314. doi:<a href="https://doi.org/10.1016/j.neuron.2016.12.018">10.1016/j.neuron.2016.12.018</a>
  apa: Gan, J., Weng, S.-M., Pernia-Andrade, A., Csicsvari, J. L., &#38; Jonas, P.
    M. (2017). Phase-locked inhibition, but not excitation, underlies hippocampal
    ripple oscillations in awake mice in vivo. <i>Neuron</i>. Elsevier. <a href="https://doi.org/10.1016/j.neuron.2016.12.018">https://doi.org/10.1016/j.neuron.2016.12.018</a>
  chicago: Gan, Jian, Shih-Ming Weng, Alejandro Pernia-Andrade, Jozsef L Csicsvari,
    and Peter M Jonas. “Phase-Locked Inhibition, but Not Excitation, Underlies Hippocampal
    Ripple Oscillations in Awake Mice in Vivo.” <i>Neuron</i>. Elsevier, 2017. <a
    href="https://doi.org/10.1016/j.neuron.2016.12.018">https://doi.org/10.1016/j.neuron.2016.12.018</a>.
  ieee: J. Gan, S.-M. Weng, A. Pernia-Andrade, J. L. Csicsvari, and P. M. Jonas, “Phase-locked
    inhibition, but not excitation, underlies hippocampal ripple oscillations in awake
    mice in vivo,” <i>Neuron</i>, vol. 93, no. 2. Elsevier, pp. 308–314, 2017.
  ista: Gan J, Weng S-M, Pernia-Andrade A, Csicsvari JL, Jonas PM. 2017. Phase-locked
    inhibition, but not excitation, underlies hippocampal ripple oscillations in awake
    mice in vivo. Neuron. 93(2), 308–314.
  mla: Gan, Jian, et al. “Phase-Locked Inhibition, but Not Excitation, Underlies Hippocampal
    Ripple Oscillations in Awake Mice in Vivo.” <i>Neuron</i>, vol. 93, no. 2, Elsevier,
    2017, pp. 308–14, doi:<a href="https://doi.org/10.1016/j.neuron.2016.12.018">10.1016/j.neuron.2016.12.018</a>.
  short: J. Gan, S.-M. Weng, A. Pernia-Andrade, J.L. Csicsvari, P.M. Jonas, Neuron
    93 (2017) 308–314.
date_created: 2018-12-11T11:50:15Z
date_published: 2017-01-18T00:00:00Z
date_updated: 2023-09-20T11:31:48Z
day: '18'
ddc:
- '571'
department:
- _id: PeJo
- _id: JoCs
doi: 10.1016/j.neuron.2016.12.018
ec_funded: 1
external_id:
  isi:
  - '000396428200010'
file:
- access_level: open_access
  content_type: application/pdf
  creator: system
  date_created: 2018-12-12T10:08:56Z
  date_updated: 2018-12-12T10:08:56Z
  file_id: '4719'
  file_name: IST-2017-752-v1+1_1-s2.0-S0896627316309606-main.pdf
  file_size: 2738950
  relation: main_file
file_date_updated: 2018-12-12T10:08:56Z
has_accepted_license: '1'
intvolume: '        93'
isi: 1
issue: '2'
language:
- iso: eng
month: '01'
oa: 1
oa_version: Published Version
page: 308 - 314
project:
- _id: 25C26B1E-B435-11E9-9278-68D0E5697425
  call_identifier: FWF
  grant_number: P24909-B24
  name: Mechanisms of transmitter release at GABAergic synapses
- _id: 25C0F108-B435-11E9-9278-68D0E5697425
  call_identifier: FP7
  grant_number: '268548'
  name: Nanophysiology of fast-spiking, parvalbumin-expressing GABAergic interneurons
publication: Neuron
publication_status: published
publisher: Elsevier
publist_id: '6244'
pubrep_id: '752'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Phase-locked inhibition, but not excitation, underlies hippocampal ripple oscillations
  in awake mice in vivo
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 93
year: '2017'
...
---
_id: '800'
abstract:
- lang: eng
  text: Gamma oscillations (30–150 Hz) in neuronal networks are associated with the
    processing and recall of information. We measured local field potentials in the
    dentate gyrus of freely moving mice and found that gamma activity occurs in bursts,
    which are highly heterogeneous in their spatial extensions, ranging from focal
    to global coherent events. Synaptic communication among perisomatic-inhibitory
    interneurons (PIIs) is thought to play an important role in the generation of
    hippocampal gamma patterns. However, how neuronal circuits can generate synchronous
    oscillations at different spatial scales is unknown. We analyzed paired recordings
    in dentate gyrus slices and show that synaptic signaling at interneuron-interneuron
    synapses is distance dependent. Synaptic strength declines whereas the duration
    of inhibitory signals increases with axonal distance among interconnected PIIs.
    Using neuronal network modeling, we show that distance-dependent inhibition generates
    multiple highly synchronous focal gamma bursts allowing the network to process
    complex inputs in parallel in flexibly organized neuronal centers.
article_number: '758'
article_processing_charge: No
author:
- first_name: Michael
  full_name: Strüber, Michael
  last_name: Strüber
- first_name: Jonas
  full_name: Sauer, Jonas
  last_name: Sauer
- first_name: Peter M
  full_name: Jonas, Peter M
  id: 353C1B58-F248-11E8-B48F-1D18A9856A87
  last_name: Jonas
  orcid: 0000-0001-5001-4804
- first_name: Marlene
  full_name: Bartos, Marlene
  last_name: Bartos
citation:
  ama: Strüber M, Sauer J, Jonas PM, Bartos M. Distance-dependent inhibition facilitates
    focality of gamma oscillations in the dentate gyrus. <i>Nature Communications</i>.
    2017;8(1). doi:<a href="https://doi.org/10.1038/s41467-017-00936-3">10.1038/s41467-017-00936-3</a>
  apa: Strüber, M., Sauer, J., Jonas, P. M., &#38; Bartos, M. (2017). Distance-dependent
    inhibition facilitates focality of gamma oscillations in the dentate gyrus. <i>Nature
    Communications</i>. Nature Publishing Group. <a href="https://doi.org/10.1038/s41467-017-00936-3">https://doi.org/10.1038/s41467-017-00936-3</a>
  chicago: Strüber, Michael, Jonas Sauer, Peter M Jonas, and Marlene Bartos. “Distance-Dependent
    Inhibition Facilitates Focality of Gamma Oscillations in the Dentate Gyrus.” <i>Nature
    Communications</i>. Nature Publishing Group, 2017. <a href="https://doi.org/10.1038/s41467-017-00936-3">https://doi.org/10.1038/s41467-017-00936-3</a>.
  ieee: M. Strüber, J. Sauer, P. M. Jonas, and M. Bartos, “Distance-dependent inhibition
    facilitates focality of gamma oscillations in the dentate gyrus,” <i>Nature Communications</i>,
    vol. 8, no. 1. Nature Publishing Group, 2017.
  ista: Strüber M, Sauer J, Jonas PM, Bartos M. 2017. Distance-dependent inhibition
    facilitates focality of gamma oscillations in the dentate gyrus. Nature Communications.
    8(1), 758.
  mla: Strüber, Michael, et al. “Distance-Dependent Inhibition Facilitates Focality
    of Gamma Oscillations in the Dentate Gyrus.” <i>Nature Communications</i>, vol.
    8, no. 1, 758, Nature Publishing Group, 2017, doi:<a href="https://doi.org/10.1038/s41467-017-00936-3">10.1038/s41467-017-00936-3</a>.
  short: M. Strüber, J. Sauer, P.M. Jonas, M. Bartos, Nature Communications 8 (2017).
date_created: 2018-12-11T11:48:34Z
date_published: 2017-10-02T00:00:00Z
date_updated: 2023-09-27T10:59:41Z
day: '02'
ddc:
- '571'
department:
- _id: PeJo
doi: 10.1038/s41467-017-00936-3
ec_funded: 1
external_id:
  isi:
  - '000412053100004'
file:
- access_level: open_access
  checksum: 7e2c7621afd5f802338e92e8619f024d
  content_type: application/pdf
  creator: system
  date_created: 2018-12-12T10:15:17Z
  date_updated: 2020-07-14T12:48:07Z
  file_id: '5135'
  file_name: IST-2017-914-v1+1_s41467-017-00936-3.pdf
  file_size: 4261832
  relation: main_file
file_date_updated: 2020-07-14T12:48:07Z
has_accepted_license: '1'
intvolume: '         8'
isi: 1
issue: '1'
language:
- iso: eng
month: '10'
oa: 1
oa_version: Published Version
project:
- _id: 25C0F108-B435-11E9-9278-68D0E5697425
  call_identifier: FP7
  grant_number: '268548'
  name: Nanophysiology of fast-spiking, parvalbumin-expressing GABAergic interneurons
publication: Nature Communications
publication_identifier:
  issn:
  - '20411723'
publication_status: published
publisher: Nature Publishing Group
publist_id: '6853'
pubrep_id: '914'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Distance-dependent inhibition facilitates focality of gamma oscillations in
  the dentate gyrus
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 8
year: '2017'
...
---
_id: '1432'
abstract:
- lang: eng
  text: CA3–CA3 recurrent excitatory synapses are thought to play a key role in memory
    storage and pattern completion. Whether the plasticity properties of these synapses
    are consistent with their proposed network functions remains unclear. Here, we
    examine the properties of spike timing-dependent plasticity (STDP) at CA3–CA3
    synapses. Low-frequency pairing of excitatory postsynaptic potentials (EPSPs)
    and action potentials (APs) induces long-term potentiation (LTP), independent
    of temporal order. The STDP curve is symmetric and broad (half-width ~150 ms).
    Consistent with these STDP induction properties, AP–EPSP sequences lead to supralinear
    summation of spine [Ca2+] transients. Furthermore, afterdepolarizations (ADPs)
    following APs efficiently propagate into dendrites of CA3 pyramidal neurons, and
    EPSPs summate with dendritic ADPs. In autoassociative network models, storage
    and recall are more robust with symmetric than with asymmetric STDP rules. Thus,
    a specialized STDP induction rule allows reliable storage and recall of information
    in the hippocampal CA3 network.
acknowledgement: 'We thank Jozsef Csicsvari and Nelson Spruston for critically reading
  the manuscript. We also thank A. Schlögl for programming, F. Marr for technical
  assistance and E. Kramberger for manuscript editing. '
article_number: '11552'
author:
- first_name: Rajiv Kumar
  full_name: Mishra, Rajiv Kumar
  id: 46CB58F2-F248-11E8-B48F-1D18A9856A87
  last_name: Mishra
- first_name: Sooyun
  full_name: Kim, Sooyun
  id: 394AB1C8-F248-11E8-B48F-1D18A9856A87
  last_name: Kim
- first_name: José
  full_name: Guzmán, José
  id: 30CC5506-F248-11E8-B48F-1D18A9856A87
  last_name: Guzmán
  orcid: 0000-0003-2209-5242
- first_name: Peter M
  full_name: Jonas, Peter M
  id: 353C1B58-F248-11E8-B48F-1D18A9856A87
  last_name: Jonas
  orcid: 0000-0001-5001-4804
citation:
  ama: Mishra RK, Kim S, Guzmán J, Jonas PM. Symmetric spike timing-dependent plasticity
    at CA3–CA3 synapses optimizes storage and recall in autoassociative networks.
    <i>Nature Communications</i>. 2016;7. doi:<a href="https://doi.org/10.1038/ncomms11552">10.1038/ncomms11552</a>
  apa: Mishra, R. K., Kim, S., Guzmán, J., &#38; Jonas, P. M. (2016). Symmetric spike
    timing-dependent plasticity at CA3–CA3 synapses optimizes storage and recall in
    autoassociative networks. <i>Nature Communications</i>. Nature Publishing Group.
    <a href="https://doi.org/10.1038/ncomms11552">https://doi.org/10.1038/ncomms11552</a>
  chicago: Mishra, Rajiv Kumar, Sooyun Kim, José Guzmán, and Peter M Jonas. “Symmetric
    Spike Timing-Dependent Plasticity at CA3–CA3 Synapses Optimizes Storage and Recall
    in Autoassociative Networks.” <i>Nature Communications</i>. Nature Publishing
    Group, 2016. <a href="https://doi.org/10.1038/ncomms11552">https://doi.org/10.1038/ncomms11552</a>.
  ieee: R. K. Mishra, S. Kim, J. Guzmán, and P. M. Jonas, “Symmetric spike timing-dependent
    plasticity at CA3–CA3 synapses optimizes storage and recall in autoassociative
    networks,” <i>Nature Communications</i>, vol. 7. Nature Publishing Group, 2016.
  ista: Mishra RK, Kim S, Guzmán J, Jonas PM. 2016. Symmetric spike timing-dependent
    plasticity at CA3–CA3 synapses optimizes storage and recall in autoassociative
    networks. Nature Communications. 7, 11552.
  mla: Mishra, Rajiv Kumar, et al. “Symmetric Spike Timing-Dependent Plasticity at
    CA3–CA3 Synapses Optimizes Storage and Recall in Autoassociative Networks.” <i>Nature
    Communications</i>, vol. 7, 11552, Nature Publishing Group, 2016, doi:<a href="https://doi.org/10.1038/ncomms11552">10.1038/ncomms11552</a>.
  short: R.K. Mishra, S. Kim, J. Guzmán, P.M. Jonas, Nature Communications 7 (2016).
date_created: 2018-12-11T11:51:59Z
date_published: 2016-05-13T00:00:00Z
date_updated: 2023-09-07T11:55:25Z
day: '13'
ddc:
- '570'
department:
- _id: PeJo
doi: 10.1038/ncomms11552
ec_funded: 1
file:
- access_level: open_access
  checksum: 7e84d0392348c874d473b62f1042de22
  content_type: application/pdf
  creator: system
  date_created: 2018-12-12T10:18:33Z
  date_updated: 2020-07-14T12:44:53Z
  file_id: '5355'
  file_name: IST-2016-582-v1+1_ncomms11552.pdf
  file_size: 4510512
  relation: main_file
file_date_updated: 2020-07-14T12:44:53Z
has_accepted_license: '1'
intvolume: '         7'
language:
- iso: eng
month: '05'
oa: 1
oa_version: Published Version
project:
- _id: 25C26B1E-B435-11E9-9278-68D0E5697425
  call_identifier: FWF
  grant_number: P24909-B24
  name: Mechanisms of transmitter release at GABAergic synapses
- _id: 25C0F108-B435-11E9-9278-68D0E5697425
  call_identifier: FP7
  grant_number: '268548'
  name: Nanophysiology of fast-spiking, parvalbumin-expressing GABAergic interneurons
publication: Nature Communications
publication_status: published
publisher: Nature Publishing Group
publist_id: '5766'
pubrep_id: '582'
quality_controlled: '1'
related_material:
  record:
  - id: '1396'
    relation: dissertation_contains
    status: public
scopus_import: 1
status: public
title: Symmetric spike timing-dependent plasticity at CA3–CA3 synapses optimizes storage
  and recall in autoassociative networks
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 3E5EF7F0-F248-11E8-B48F-1D18A9856A87
volume: 7
year: '2016'
...
---
_id: '1323'
abstract:
- lang: eng
  text: Mossy fiber synapses on CA3 pyramidal cells are 'conditional detonators' that
    reliably discharge postsynaptic targets. The 'conditional' nature implies that
    burst activity in dentate gyrus granule cells is required for detonation. Whether
    single unitary excitatory postsynaptic potentials (EPSPs) trigger spikes in CA3
    neurons remains unknown. Mossy fiber synapses exhibit both pronounced short-term
    facilitation and uniquely large post-tetanic potentiation (PTP). We tested whether
    PTP could convert mossy fiber synapses from subdetonator into detonator mode,
    using a recently developed method to selectively and noninvasively stimulate individual
    presynaptic terminals in rat brain slices. Unitary EPSPs failed to initiate a
    spike in CA3 neurons under control conditions, but reliably discharged them after
    induction of presynaptic short-term plasticity. Remarkably, PTP switched mossy
    fiber synapses into full detonators for tens of seconds. Plasticity-dependent
    detonation may be critical for efficient coding, storage, and recall of information
    in the granule cell–CA3 cell network.
acknowledged_ssus:
- _id: M-Shop
- _id: PreCl
article_number: e17977
author:
- first_name: Nicholas
  full_name: Vyleta, Nicholas
  id: 36C4978E-F248-11E8-B48F-1D18A9856A87
  last_name: Vyleta
- first_name: Carolina
  full_name: Borges Merjane, Carolina
  id: 4305C450-F248-11E8-B48F-1D18A9856A87
  last_name: Borges Merjane
  orcid: 0000-0003-0005-401X
- first_name: Peter M
  full_name: Jonas, Peter M
  id: 353C1B58-F248-11E8-B48F-1D18A9856A87
  last_name: Jonas
  orcid: 0000-0001-5001-4804
citation:
  ama: Vyleta N, Borges Merjane C, Jonas PM. Plasticity-dependent, full detonation
    at hippocampal mossy fiber–CA3 pyramidal neuron synapses. <i>eLife</i>. 2016;5.
    doi:<a href="https://doi.org/10.7554/eLife.17977">10.7554/eLife.17977</a>
  apa: Vyleta, N., Borges Merjane, C., &#38; Jonas, P. M. (2016). Plasticity-dependent,
    full detonation at hippocampal mossy fiber–CA3 pyramidal neuron synapses. <i>ELife</i>.
    eLife Sciences Publications. <a href="https://doi.org/10.7554/eLife.17977">https://doi.org/10.7554/eLife.17977</a>
  chicago: Vyleta, Nicholas, Carolina Borges Merjane, and Peter M Jonas. “Plasticity-Dependent,
    Full Detonation at Hippocampal Mossy Fiber–CA3 Pyramidal Neuron Synapses.” <i>ELife</i>.
    eLife Sciences Publications, 2016. <a href="https://doi.org/10.7554/eLife.17977">https://doi.org/10.7554/eLife.17977</a>.
  ieee: N. Vyleta, C. Borges Merjane, and P. M. Jonas, “Plasticity-dependent, full
    detonation at hippocampal mossy fiber–CA3 pyramidal neuron synapses,” <i>eLife</i>,
    vol. 5. eLife Sciences Publications, 2016.
  ista: Vyleta N, Borges Merjane C, Jonas PM. 2016. Plasticity-dependent, full detonation
    at hippocampal mossy fiber–CA3 pyramidal neuron synapses. eLife. 5, e17977.
  mla: Vyleta, Nicholas, et al. “Plasticity-Dependent, Full Detonation at Hippocampal
    Mossy Fiber–CA3 Pyramidal Neuron Synapses.” <i>ELife</i>, vol. 5, e17977, eLife
    Sciences Publications, 2016, doi:<a href="https://doi.org/10.7554/eLife.17977">10.7554/eLife.17977</a>.
  short: N. Vyleta, C. Borges Merjane, P.M. Jonas, ELife 5 (2016).
date_created: 2018-12-11T11:51:22Z
date_published: 2016-10-25T00:00:00Z
date_updated: 2023-02-21T10:34:24Z
day: '25'
ddc:
- '571'
- '572'
department:
- _id: PeJo
doi: 10.7554/eLife.17977
ec_funded: 1
file:
- access_level: open_access
  checksum: a7201280c571bed88ebd459ce5ce6a47
  content_type: application/pdf
  creator: system
  date_created: 2018-12-12T10:17:05Z
  date_updated: 2020-07-14T12:44:44Z
  file_id: '5257'
  file_name: IST-2016-715-v1+1_e17977-download.pdf
  file_size: 1477891
  relation: main_file
file_date_updated: 2020-07-14T12:44:44Z
has_accepted_license: '1'
intvolume: '         5'
language:
- iso: eng
month: '10'
oa: 1
oa_version: Published Version
project:
- _id: 25C0F108-B435-11E9-9278-68D0E5697425
  call_identifier: FP7
  grant_number: '268548'
  name: Nanophysiology of fast-spiking, parvalbumin-expressing GABAergic interneurons
- _id: 25B7EB9E-B435-11E9-9278-68D0E5697425
  call_identifier: H2020
  grant_number: '692692'
  name: Biophysics and circuit function of a giant cortical glumatergic synapse
publication: eLife
publication_status: published
publisher: eLife Sciences Publications
publist_id: '5947'
pubrep_id: '715'
quality_controlled: '1'
scopus_import: 1
status: public
title: Plasticity-dependent, full detonation at hippocampal mossy fiber–CA3 pyramidal
  neuron synapses
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 3E5EF7F0-F248-11E8-B48F-1D18A9856A87
volume: 5
year: '2016'
...
---
_id: '1350'
abstract:
- lang: eng
  text: "The hippocampal CA3 region plays a key role in learning and memory. Recurrent
    CA3–CA3\r\nsynapses are thought to be the subcellular substrate of pattern completion.
    However, the\r\nsynaptic mechanisms of this network computation remain enigmatic.
    To investigate these mechanisms, we combined functional connectivity analysis
    with network modeling.\r\nSimultaneous recording fromup to eight CA3 pyramidal
    neurons revealed that connectivity was sparse, spatially uniform, and highly enriched
    in disynaptic motifs (reciprocal, convergence,divergence, and chain motifs). Unitary
    connections were composed of one or two synaptic contacts, suggesting efficient
    use of postsynaptic space. Real-size modeling indicated that CA3 networks with
    sparse connectivity, disynaptic motifs, and single-contact connections robustly
    generated pattern completion.Thus, macro- and microconnectivity contribute to
    efficient\r\nmemory storage and retrieval in hippocampal networks."
acknowledged_ssus:
- _id: ScienComp
author:
- first_name: José
  full_name: Guzmán, José
  id: 30CC5506-F248-11E8-B48F-1D18A9856A87
  last_name: Guzmán
- first_name: Alois
  full_name: Schlögl, Alois
  id: 45BF87EE-F248-11E8-B48F-1D18A9856A87
  last_name: Schlögl
  orcid: 0000-0002-5621-8100
- first_name: Michael
  full_name: Frotscher, Michael
  last_name: Frotscher
- first_name: Peter M
  full_name: Jonas, Peter M
  id: 353C1B58-F248-11E8-B48F-1D18A9856A87
  last_name: Jonas
  orcid: 0000-0001-5001-4804
citation:
  ama: Guzmán J, Schlögl A, Frotscher M, Jonas PM. Synaptic mechanisms of pattern
    completion in the hippocampal CA3 network. <i>Science</i>. 2016;353(6304):1117-1123.
    doi:<a href="https://doi.org/10.1126/science.aaf1836">10.1126/science.aaf1836</a>
  apa: Guzmán, J., Schlögl, A., Frotscher, M., &#38; Jonas, P. M. (2016). Synaptic
    mechanisms of pattern completion in the hippocampal CA3 network. <i>Science</i>.
    American Association for the Advancement of Science. <a href="https://doi.org/10.1126/science.aaf1836">https://doi.org/10.1126/science.aaf1836</a>
  chicago: Guzmán, José, Alois Schlögl, Michael Frotscher, and Peter M Jonas. “Synaptic
    Mechanisms of Pattern Completion in the Hippocampal CA3 Network.” <i>Science</i>.
    American Association for the Advancement of Science, 2016. <a href="https://doi.org/10.1126/science.aaf1836">https://doi.org/10.1126/science.aaf1836</a>.
  ieee: J. Guzmán, A. Schlögl, M. Frotscher, and P. M. Jonas, “Synaptic mechanisms
    of pattern completion in the hippocampal CA3 network,” <i>Science</i>, vol. 353,
    no. 6304. American Association for the Advancement of Science, pp. 1117–1123,
    2016.
  ista: Guzmán J, Schlögl A, Frotscher M, Jonas PM. 2016. Synaptic mechanisms of pattern
    completion in the hippocampal CA3 network. Science. 353(6304), 1117–1123.
  mla: Guzmán, José, et al. “Synaptic Mechanisms of Pattern Completion in the Hippocampal
    CA3 Network.” <i>Science</i>, vol. 353, no. 6304, American Association for the
    Advancement of Science, 2016, pp. 1117–23, doi:<a href="https://doi.org/10.1126/science.aaf1836">10.1126/science.aaf1836</a>.
  short: J. Guzmán, A. Schlögl, M. Frotscher, P.M. Jonas, Science 353 (2016) 1117–1123.
date_created: 2018-12-11T11:51:31Z
date_published: 2016-09-09T00:00:00Z
date_updated: 2021-01-12T06:50:04Z
day: '09'
ddc:
- '570'
department:
- _id: ScienComp
- _id: PeJo
doi: 10.1126/science.aaf1836
ec_funded: 1
file:
- access_level: open_access
  checksum: 89caefa4e181424cbf0aecc835fcc5ec
  content_type: application/pdf
  creator: system
  date_created: 2018-12-12T10:12:27Z
  date_updated: 2020-07-14T12:44:46Z
  file_id: '4945'
  file_name: IST-2017-823-v1+1_aaf1836_CombinedPDF_v2-1.pdf
  file_size: 19408143
  relation: main_file
file_date_updated: 2020-07-14T12:44:46Z
has_accepted_license: '1'
intvolume: '       353'
issue: '6304'
language:
- iso: eng
month: '09'
oa: 1
oa_version: Preprint
page: 1117 - 1123
project:
- _id: 25C0F108-B435-11E9-9278-68D0E5697425
  call_identifier: FP7
  grant_number: '268548'
  name: Nanophysiology of fast-spiking, parvalbumin-expressing GABAergic interneurons
- _id: 25C26B1E-B435-11E9-9278-68D0E5697425
  call_identifier: FWF
  grant_number: P24909-B24
  name: Mechanisms of transmitter release at GABAergic synapses
publication: Science
publication_status: published
publisher: American Association for the Advancement of Science
publist_id: '5899'
pubrep_id: '823'
quality_controlled: '1'
scopus_import: 1
status: public
title: Synaptic mechanisms of pattern completion in the hippocampal CA3 network
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 353
year: '2016'
...
---
_id: '1614'
abstract:
- lang: eng
  text: 'GABAergic perisoma-inhibiting fast-spiking interneurons (PIIs) effectively
    control the activity of large neuron populations by their wide axonal arborizations.
    It is generally assumed that the output of one PII to its target cells is strong
    and rapid. Here, we show that, unexpectedly, both strength and time course of
    PII-mediated perisomatic inhibition change with distance between synaptically
    connected partners in the rodent hippocampus. Synaptic signals become weaker due
    to lower contact numbers and decay more slowly with distance, very likely resulting
    from changes in GABAA receptor subunit composition. When distance-dependent synaptic
    inhibition is introduced to a rhythmically active neuronal network model, randomly
    driven principal cell assemblies are strongly synchronized by the PIIs, leading
    to higher precision in principal cell spike times than in a network with uniform
    synaptic inhibition. '
author:
- first_name: Michael
  full_name: Strüber, Michael
  last_name: Strüber
- first_name: Peter M
  full_name: Jonas, Peter M
  id: 353C1B58-F248-11E8-B48F-1D18A9856A87
  last_name: Jonas
  orcid: 0000-0001-5001-4804
- first_name: Marlene
  full_name: Bartos, Marlene
  last_name: Bartos
citation:
  ama: Strüber M, Jonas PM, Bartos M. Strength and duration of perisomatic GABAergic
    inhibition depend on distance between synaptically connected cells. <i>PNAS</i>.
    2015;112(4):1220-1225. doi:<a href="https://doi.org/10.1073/pnas.1412996112">10.1073/pnas.1412996112</a>
  apa: Strüber, M., Jonas, P. M., &#38; Bartos, M. (2015). Strength and duration of
    perisomatic GABAergic inhibition depend on distance between synaptically connected
    cells. <i>PNAS</i>. National Academy of Sciences. <a href="https://doi.org/10.1073/pnas.1412996112">https://doi.org/10.1073/pnas.1412996112</a>
  chicago: Strüber, Michael, Peter M Jonas, and Marlene Bartos. “Strength and Duration
    of Perisomatic GABAergic Inhibition Depend on Distance between Synaptically Connected
    Cells.” <i>PNAS</i>. National Academy of Sciences, 2015. <a href="https://doi.org/10.1073/pnas.1412996112">https://doi.org/10.1073/pnas.1412996112</a>.
  ieee: M. Strüber, P. M. Jonas, and M. Bartos, “Strength and duration of perisomatic
    GABAergic inhibition depend on distance between synaptically connected cells,”
    <i>PNAS</i>, vol. 112, no. 4. National Academy of Sciences, pp. 1220–1225, 2015.
  ista: Strüber M, Jonas PM, Bartos M. 2015. Strength and duration of perisomatic
    GABAergic inhibition depend on distance between synaptically connected cells.
    PNAS. 112(4), 1220–1225.
  mla: Strüber, Michael, et al. “Strength and Duration of Perisomatic GABAergic Inhibition
    Depend on Distance between Synaptically Connected Cells.” <i>PNAS</i>, vol. 112,
    no. 4, National Academy of Sciences, 2015, pp. 1220–25, doi:<a href="https://doi.org/10.1073/pnas.1412996112">10.1073/pnas.1412996112</a>.
  short: M. Strüber, P.M. Jonas, M. Bartos, PNAS 112 (2015) 1220–1225.
date_created: 2018-12-11T11:53:02Z
date_published: 2015-01-27T00:00:00Z
date_updated: 2021-01-12T06:52:01Z
day: '27'
ddc:
- '570'
department:
- _id: PeJo
doi: 10.1073/pnas.1412996112
ec_funded: 1
external_id:
  pmid:
  - '25583495'
file:
- access_level: open_access
  checksum: 6703309a1f58493cf5a704211fb6ebed
  content_type: application/pdf
  creator: dernst
  date_created: 2019-01-17T07:52:40Z
  date_updated: 2020-07-14T12:45:07Z
  file_id: '5838'
  file_name: 2015_PNAS_Strueber.pdf
  file_size: 1280860
  relation: main_file
file_date_updated: 2020-07-14T12:45:07Z
has_accepted_license: '1'
intvolume: '       112'
issue: '4'
language:
- iso: eng
month: '01'
oa: 1
oa_version: Published Version
page: 1220 - 1225
pmid: 1
project:
- _id: 25C26B1E-B435-11E9-9278-68D0E5697425
  call_identifier: FWF
  grant_number: P24909-B24
  name: Mechanisms of transmitter release at GABAergic synapses
- _id: 25C0F108-B435-11E9-9278-68D0E5697425
  call_identifier: FP7
  grant_number: '268548'
  name: Nanophysiology of fast-spiking, parvalbumin-expressing GABAergic interneurons
publication: PNAS
publication_status: published
publisher: National Academy of Sciences
publist_id: '5552'
quality_controlled: '1'
scopus_import: 1
status: public
title: Strength and duration of perisomatic GABAergic inhibition depend on distance
  between synaptically connected cells
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 112
year: '2015'
...
---
_id: '2002'
abstract:
- lang: eng
  text: Oriens-lacunosum moleculare (O-LM) interneurons in the CA1 region of the hippocampus
    play a key role in feedback inhibition and in the control of network activity.
    However, how these cells are efficiently activated in the network remains unclear.
    To address this question, I performed recordings from CA1 pyramidal neuron axons,
    the presynaptic fibers that provide feedback innervation of these interneurons.
    Two forms of axonal action potential (AP) modulation were identified. First, repetitive
    stimulation resulted in activity-dependent AP broadening. Broadening showed fast
    onset, with marked changes in AP shape following a single AP. Second, tonic depolarization
    in CA1 pyramidal neuron somata induced AP broadening in the axon, and depolarization-induced
    broadening summated with activity-dependent broadening. Outsideout patch recordings
    from CA1 pyramidal neuron axons revealed a high density of a-dendrotoxin (α-DTX)-sensitive,
    inactivating K+ channels, suggesting that K+ channel inactivation mechanistically
    contributes to AP broadening. To examine the functional consequences of axonal
    AP modulation for synaptic transmission, I performed paired recordings between
    synaptically connected CA1 pyramidal neurons and O-LM interneurons. CA1 pyramidal
    neuron-O-LM interneuron excitatory postsynaptic currents (EPSCs) showed facilitation
    during both repetitive stimulation and tonic depolarization of the presynaptic
    neuron. Both effects were mimicked and occluded by α-DTX, suggesting that they
    were mediated by K+ channel inactivation. Therefore, axonal AP modulation can
    greatly facilitate the activation of O-LM interneurons. In conclusion, modulation
    of AP shape in CA1 pyramidal neuron axons substantially enhances the efficacy
    of principal neuron-interneuron synapses, promoting the activation of O-LM interneurons
    in recurrent inhibitory microcircuits.
article_number: '0113124'
author:
- first_name: Sooyun
  full_name: Kim, Sooyun
  id: 394AB1C8-F248-11E8-B48F-1D18A9856A87
  last_name: Kim
citation:
  ama: Kim S. Action potential modulation in CA1 pyramidal neuron axons facilitates
    OLM interneuron activation in recurrent inhibitory microcircuits of rat hippocampus.
    <i>PLoS One</i>. 2014;9(11). doi:<a href="https://doi.org/10.1371/journal.pone.0113124">10.1371/journal.pone.0113124</a>
  apa: Kim, S. (2014). Action potential modulation in CA1 pyramidal neuron axons facilitates
    OLM interneuron activation in recurrent inhibitory microcircuits of rat hippocampus.
    <i>PLoS One</i>. Public Library of Science. <a href="https://doi.org/10.1371/journal.pone.0113124">https://doi.org/10.1371/journal.pone.0113124</a>
  chicago: Kim, Sooyun. “Action Potential Modulation in CA1 Pyramidal Neuron Axons
    Facilitates OLM Interneuron Activation in Recurrent Inhibitory Microcircuits of
    Rat Hippocampus.” <i>PLoS One</i>. Public Library of Science, 2014. <a href="https://doi.org/10.1371/journal.pone.0113124">https://doi.org/10.1371/journal.pone.0113124</a>.
  ieee: S. Kim, “Action potential modulation in CA1 pyramidal neuron axons facilitates
    OLM interneuron activation in recurrent inhibitory microcircuits of rat hippocampus,”
    <i>PLoS One</i>, vol. 9, no. 11. Public Library of Science, 2014.
  ista: Kim S. 2014. Action potential modulation in CA1 pyramidal neuron axons facilitates
    OLM interneuron activation in recurrent inhibitory microcircuits of rat hippocampus.
    PLoS One. 9(11), 0113124.
  mla: Kim, Sooyun. “Action Potential Modulation in CA1 Pyramidal Neuron Axons Facilitates
    OLM Interneuron Activation in Recurrent Inhibitory Microcircuits of Rat Hippocampus.”
    <i>PLoS One</i>, vol. 9, no. 11, 0113124, Public Library of Science, 2014, doi:<a
    href="https://doi.org/10.1371/journal.pone.0113124">10.1371/journal.pone.0113124</a>.
  short: S. Kim, PLoS One 9 (2014).
date_created: 2018-12-11T11:55:09Z
date_published: 2014-11-19T00:00:00Z
date_updated: 2021-01-12T06:54:39Z
day: '19'
ddc:
- '570'
department:
- _id: PeJo
doi: 10.1371/journal.pone.0113124
ec_funded: 1
file:
- access_level: open_access
  checksum: 85e4f4ea144f827272aaf376b2830564
  content_type: application/pdf
  creator: system
  date_created: 2018-12-12T10:14:52Z
  date_updated: 2020-07-14T12:45:24Z
  file_id: '5107'
  file_name: IST-2016-434-v1+1_journal.pone.0113124.pdf
  file_size: 5179993
  relation: main_file
file_date_updated: 2020-07-14T12:45:24Z
has_accepted_license: '1'
intvolume: '         9'
issue: '11'
language:
- iso: eng
license: https://creativecommons.org/licenses/by-sa/4.0/
month: '11'
oa: 1
oa_version: Published Version
project:
- _id: 25C0F108-B435-11E9-9278-68D0E5697425
  call_identifier: FP7
  grant_number: '268548'
  name: Nanophysiology of fast-spiking, parvalbumin-expressing GABAergic interneurons
publication: PLoS One
publication_status: published
publisher: Public Library of Science
publist_id: '5074'
pubrep_id: '434'
quality_controlled: '1'
scopus_import: 1
status: public
title: Action potential modulation in CA1 pyramidal neuron axons facilitates OLM interneuron
  activation in recurrent inhibitory microcircuits of rat hippocampus
tmp:
  image: /images/cc_by_sa.png
  legal_code_url: https://creativecommons.org/licenses/by-sa/4.0/legalcode
  name: Creative Commons Attribution-ShareAlike 4.0 International Public License (CC
    BY-SA 4.0)
  short: CC BY-SA (4.0)
type: journal_article
user_id: 4435EBFC-F248-11E8-B48F-1D18A9856A87
volume: 9
year: '2014'
...
---
_id: '2031'
abstract:
- lang: eng
  text: A puzzling property of synaptic transmission, originally established at the
    neuromuscular junction, is that the time course of transmitter release is independent
    of the extracellular Ca2+ concentration ([Ca2+]o), whereas the rate of release
    is highly [Ca2+]o-dependent. Here, we examine the time course of release at inhibitory
    basket cell-Purkinje cell synapses and show that it is independent of [Ca2+]o.
    Modeling of Ca2+-dependent transmitter release suggests that the invariant time
    course of release critically depends on tight coupling between Ca2+ channels and
    release sensors. Experiments with exogenous Ca2+ chelators reveal that channel-sensor
    coupling at basket cell-Purkinje cell synapses is very tight, with a mean distance
    of 10–20 nm. Thus, tight channel-sensor coupling provides a mechanistic explanation
    for the apparent [Ca2+]o independence of the time course of release.
author:
- first_name: Itaru
  full_name: Arai, Itaru
  id: 32A73F6C-F248-11E8-B48F-1D18A9856A87
  last_name: Arai
- first_name: Peter M
  full_name: Jonas, Peter M
  id: 353C1B58-F248-11E8-B48F-1D18A9856A87
  last_name: Jonas
  orcid: 0000-0001-5001-4804
citation:
  ama: Arai  itaru, Jonas PM. Nanodomain coupling explains Ca^2+ independence of transmitter
    release time course at a fast central synapse. <i>eLife</i>. 2014;3. doi:<a href="https://doi.org/10.7554/eLife.04057">10.7554/eLife.04057</a>
  apa: Arai,  itaru, &#38; Jonas, P. M. (2014). Nanodomain coupling explains Ca^2+
    independence of transmitter release time course at a fast central synapse. <i>ELife</i>.
    eLife Sciences Publications. <a href="https://doi.org/10.7554/eLife.04057">https://doi.org/10.7554/eLife.04057</a>
  chicago: Arai, itaru, and Peter M Jonas. “Nanodomain Coupling Explains Ca^2+ Independence
    of Transmitter Release Time Course at a Fast Central Synapse.” <i>ELife</i>. eLife
    Sciences Publications, 2014. <a href="https://doi.org/10.7554/eLife.04057">https://doi.org/10.7554/eLife.04057</a>.
  ieee: itaru Arai and P. M. Jonas, “Nanodomain coupling explains Ca^2+ independence
    of transmitter release time course at a fast central synapse,” <i>eLife</i>, vol.
    3. eLife Sciences Publications, 2014.
  ista: Arai  itaru, Jonas PM. 2014. Nanodomain coupling explains Ca^2+ independence
    of transmitter release time course at a fast central synapse. eLife. 3.
  mla: Arai, itaru, and Peter M. Jonas. “Nanodomain Coupling Explains Ca^2+ Independence
    of Transmitter Release Time Course at a Fast Central Synapse.” <i>ELife</i>, vol.
    3, eLife Sciences Publications, 2014, doi:<a href="https://doi.org/10.7554/eLife.04057">10.7554/eLife.04057</a>.
  short: itaru Arai, P.M. Jonas, ELife 3 (2014).
date_created: 2018-12-11T11:55:19Z
date_published: 2014-12-09T00:00:00Z
date_updated: 2021-01-12T06:54:51Z
day: '09'
ddc:
- '570'
department:
- _id: PeJo
doi: 10.7554/eLife.04057
ec_funded: 1
file:
- access_level: open_access
  checksum: c240f915450d4ebe8f95043a2a8c7b1a
  content_type: application/pdf
  creator: system
  date_created: 2018-12-12T10:14:41Z
  date_updated: 2020-07-14T12:45:26Z
  file_id: '5094'
  file_name: IST-2016-421-v1+1_e04057.full.pdf
  file_size: 2239563
  relation: main_file
file_date_updated: 2020-07-14T12:45:26Z
has_accepted_license: '1'
intvolume: '         3'
language:
- iso: eng
month: '12'
oa: 1
oa_version: Submitted Version
project:
- _id: 25C26B1E-B435-11E9-9278-68D0E5697425
  call_identifier: FWF
  grant_number: P24909-B24
  name: Mechanisms of transmitter release at GABAergic synapses
- _id: 25C0F108-B435-11E9-9278-68D0E5697425
  call_identifier: FP7
  grant_number: '268548'
  name: Nanophysiology of fast-spiking, parvalbumin-expressing GABAergic interneurons
publication: eLife
publication_status: published
publisher: eLife Sciences Publications
publist_id: '5041'
pubrep_id: '421'
quality_controlled: '1'
scopus_import: 1
status: public
title: Nanodomain coupling explains Ca^2+ independence of transmitter release time
  course at a fast central synapse
type: journal_article
user_id: 4435EBFC-F248-11E8-B48F-1D18A9856A87
volume: 3
year: '2014'
...
---
_id: '2062'
abstract:
- lang: eng
  text: The success story of fast-spiking, parvalbumin-positive (PV+) GABAergic interneurons
    (GABA, γ-aminobutyric acid) in the mammalian central nervous system is noteworthy.
    In 1995, the properties of these interneurons were completely unknown. Twenty
    years later, thanks to the massive use of subcellular patch-clamp techniques,
    simultaneous multiple-cell recording, optogenetics, in vivo measurements, and
    computational approaches, our knowledge about PV+ interneurons became more extensive
    than for several types of pyramidal neurons. These findings have implications
    beyond the “small world” of basic research on GABAergic cells. For example, the
    results provide a first proof of principle that neuroscientists might be able
    to close the gaps between the molecular, cellular, network, and behavioral levels,
    representing one of the main challenges at the present time. Furthermore, the
    results may form the basis for PV+ interneurons as therapeutic targets for brain
    disease in the future. However, much needs to be learned about the basic function
    of these interneurons before clinical neuroscientists will be able to use PV+
    interneurons for therapeutic purposes.
article_number: '1255263'
author:
- first_name: Hua
  full_name: Hu, Hua
  id: 4AC0145C-F248-11E8-B48F-1D18A9856A87
  last_name: Hu
- first_name: Jian
  full_name: Gan, Jian
  id: 3614E438-F248-11E8-B48F-1D18A9856A87
  last_name: Gan
- first_name: Peter M
  full_name: Jonas, Peter M
  id: 353C1B58-F248-11E8-B48F-1D18A9856A87
  last_name: Jonas
  orcid: 0000-0001-5001-4804
citation:
  ama: 'Hu H, Gan J, Jonas PM. Fast-spiking parvalbumin^+ GABAergic interneurons:
    From cellular design to microcircuit function. <i>Science</i>. 2014;345(6196).
    doi:<a href="https://doi.org/10.1126/science.1255263">10.1126/science.1255263</a>'
  apa: 'Hu, H., Gan, J., &#38; Jonas, P. M. (2014). Fast-spiking parvalbumin^+ GABAergic
    interneurons: From cellular design to microcircuit function. <i>Science</i>. American
    Association for the Advancement of Science. <a href="https://doi.org/10.1126/science.1255263">https://doi.org/10.1126/science.1255263</a>'
  chicago: 'Hu, Hua, Jian Gan, and Peter M Jonas. “Fast-Spiking Parvalbumin^+ GABAergic
    Interneurons: From Cellular Design to Microcircuit Function.” <i>Science</i>.
    American Association for the Advancement of Science, 2014. <a href="https://doi.org/10.1126/science.1255263">https://doi.org/10.1126/science.1255263</a>.'
  ieee: 'H. Hu, J. Gan, and P. M. Jonas, “Fast-spiking parvalbumin^+ GABAergic interneurons:
    From cellular design to microcircuit function,” <i>Science</i>, vol. 345, no.
    6196. American Association for the Advancement of Science, 2014.'
  ista: 'Hu H, Gan J, Jonas PM. 2014. Fast-spiking parvalbumin^+ GABAergic interneurons:
    From cellular design to microcircuit function. Science. 345(6196), 1255263.'
  mla: 'Hu, Hua, et al. “Fast-Spiking Parvalbumin^+ GABAergic Interneurons: From Cellular
    Design to Microcircuit Function.” <i>Science</i>, vol. 345, no. 6196, 1255263,
    American Association for the Advancement of Science, 2014, doi:<a href="https://doi.org/10.1126/science.1255263">10.1126/science.1255263</a>.'
  short: H. Hu, J. Gan, P.M. Jonas, Science 345 (2014).
date_created: 2018-12-11T11:55:29Z
date_published: 2014-08-01T00:00:00Z
date_updated: 2021-01-12T06:55:03Z
day: '01'
ddc:
- '570'
department:
- _id: PeJo
doi: 10.1126/science.1255263
ec_funded: 1
file:
- access_level: open_access
  checksum: a0036a589037d37e86364fa25cc0a82f
  content_type: application/pdf
  creator: system
  date_created: 2018-12-12T10:16:00Z
  date_updated: 2020-07-14T12:45:27Z
  file_id: '5185'
  file_name: IST-2017-821-v1+1_1255263JonasPVReviewTextR_Final.pdf
  file_size: 215514
  relation: main_file
- access_level: open_access
  checksum: e1f57d2713725449cb898fdcb8ef47b8
  content_type: application/pdf
  creator: system
  date_created: 2018-12-12T10:16:01Z
  date_updated: 2020-07-14T12:45:27Z
  file_id: '5186'
  file_name: IST-2017-821-v1+2_1255263JonasPVReviewFigures_Final.pdf
  file_size: 1732723
  relation: main_file
file_date_updated: 2020-07-14T12:45:27Z
has_accepted_license: '1'
intvolume: '       345'
issue: '6196'
language:
- iso: eng
month: '08'
oa: 1
oa_version: Submitted Version
project:
- _id: 25C26B1E-B435-11E9-9278-68D0E5697425
  call_identifier: FWF
  grant_number: P24909-B24
  name: Mechanisms of transmitter release at GABAergic synapses
- _id: 25C0F108-B435-11E9-9278-68D0E5697425
  call_identifier: FP7
  grant_number: '268548'
  name: Nanophysiology of fast-spiking, parvalbumin-expressing GABAergic interneurons
publication: Science
publication_status: published
publisher: American Association for the Advancement of Science
publist_id: '4984'
pubrep_id: '821'
quality_controlled: '1'
scopus_import: 1
status: public
title: 'Fast-spiking parvalbumin^+ GABAergic interneurons: From cellular design to
  microcircuit function'
type: journal_article
user_id: 4435EBFC-F248-11E8-B48F-1D18A9856A87
volume: 345
year: '2014'
...
---
_id: '2228'
abstract:
- lang: eng
  text: Fast-spiking, parvalbumin-expressing GABAergic interneurons, a large proportion
    of which are basket cells (BCs), have a key role in feedforward and feedback inhibition,
    gamma oscillations and complex information processing. For these functions, fast
    propagation of action potentials (APs) from the soma to the presynaptic terminals
    is important. However, the functional properties of interneuron axons remain elusive.
    We examined interneuron axons by confocally targeted subcellular patch-clamp recording
    in rat hippocampal slices. APs were initiated in the proximal axon ∼20 μm from
    the soma and propagated to the distal axon with high reliability and speed. Subcellular
    mapping revealed a stepwise increase of Na^+ conductance density from the soma
    to the proximal axon, followed by a further gradual increase in the distal axon.
    Active cable modeling and experiments with partial channel block revealed that
    low axonal Na^+ conductance density was sufficient for reliability, but high Na^+
    density was necessary for both speed of propagation and fast-spiking AP phenotype.
    Our results suggest that a supercritical density of Na^+ channels compensates
    for the morphological properties of interneuron axons (small segmental diameter,
    extensive branching and high bouton density), ensuring fast AP propagation and
    high-frequency repetitive firing.
author:
- first_name: Hua
  full_name: Hu, Hua
  id: 4AC0145C-F248-11E8-B48F-1D18A9856A87
  last_name: Hu
- first_name: Peter M
  full_name: Jonas, Peter M
  id: 353C1B58-F248-11E8-B48F-1D18A9856A87
  last_name: Jonas
  orcid: 0000-0001-5001-4804
citation:
  ama: Hu H, Jonas PM. A supercritical density of Na^+ channels ensures fast signaling
    in GABAergic interneuron axons. <i>Nature Neuroscience</i>. 2014;17(5):686-693.
    doi:<a href="https://doi.org/10.1038/nn.3678">10.1038/nn.3678</a>
  apa: Hu, H., &#38; Jonas, P. M. (2014). A supercritical density of Na^+ channels
    ensures fast signaling in GABAergic interneuron axons. <i>Nature Neuroscience</i>.
    Nature Publishing Group. <a href="https://doi.org/10.1038/nn.3678">https://doi.org/10.1038/nn.3678</a>
  chicago: Hu, Hua, and Peter M Jonas. “A Supercritical Density of Na^+ Channels Ensures
    Fast Signaling in GABAergic Interneuron Axons.” <i>Nature Neuroscience</i>. Nature
    Publishing Group, 2014. <a href="https://doi.org/10.1038/nn.3678">https://doi.org/10.1038/nn.3678</a>.
  ieee: H. Hu and P. M. Jonas, “A supercritical density of Na^+ channels ensures fast
    signaling in GABAergic interneuron axons,” <i>Nature Neuroscience</i>, vol. 17,
    no. 5. Nature Publishing Group, pp. 686–693, 2014.
  ista: Hu H, Jonas PM. 2014. A supercritical density of Na^+ channels ensures fast
    signaling in GABAergic interneuron axons. Nature Neuroscience. 17(5), 686–693.
  mla: Hu, Hua, and Peter M. Jonas. “A Supercritical Density of Na^+ Channels Ensures
    Fast Signaling in GABAergic Interneuron Axons.” <i>Nature Neuroscience</i>, vol.
    17, no. 5, Nature Publishing Group, 2014, pp. 686–93, doi:<a href="https://doi.org/10.1038/nn.3678">10.1038/nn.3678</a>.
  short: H. Hu, P.M. Jonas, Nature Neuroscience 17 (2014) 686–693.
date_created: 2018-12-11T11:56:26Z
date_published: 2014-03-23T00:00:00Z
date_updated: 2021-01-12T06:56:08Z
day: '23'
department:
- _id: PeJo
doi: 10.1038/nn.3678
ec_funded: 1
intvolume: '        17'
issue: '5'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4286295/
month: '03'
oa: 1
oa_version: Submitted Version
page: 686-693
project:
- _id: 25C0F108-B435-11E9-9278-68D0E5697425
  call_identifier: FP7
  grant_number: '268548'
  name: Nanophysiology of fast-spiking, parvalbumin-expressing GABAergic interneurons
- _id: 25C26B1E-B435-11E9-9278-68D0E5697425
  call_identifier: FWF
  grant_number: P24909-B24
  name: Mechanisms of transmitter release at GABAergic synapses
publication: Nature Neuroscience
publication_identifier:
  issn:
  - '10976256'
publication_status: published
publisher: Nature Publishing Group
publist_id: '4733'
quality_controlled: '1'
scopus_import: 1
status: public
title: A supercritical density of Na^+ channels ensures fast signaling in GABAergic
  interneuron axons
type: journal_article
user_id: 4435EBFC-F248-11E8-B48F-1D18A9856A87
volume: 17
year: '2014'
...
---
_id: '2229'
abstract:
- lang: eng
  text: The distance between Ca^2+ channels and release sensors determines the speed
    and efficacy of synaptic transmission. Tight &quot;nanodomain&quot; channel-sensor
    coupling initiates transmitter release at synapses in the mature brain, whereas
    loose &quot;microdomain&quot; coupling appears restricted to early developmental
    stages. To probe the coupling configuration at a plastic synapse in the mature
    central nervous system, we performed paired recordings between mossy fiber terminals
    and CA3 pyramidal neurons in rat hippocampus. Millimolar concentrations of both
    the fast Ca^2+ chelator BAPTA [1,2-bis(2-aminophenoxy)ethane- N,N, N′,N′-tetraacetic
    acid] and the slow chelator EGTA efficiently suppressed transmitter release, indicating
    loose coupling between Ca^2+ channels and release sensors. Loose coupling enabled
    the control of initial release probability by fast endogenous Ca^2+ buffers and
    the generation of facilitation by buffer saturation. Thus, loose coupling provides
    the molecular framework for presynaptic plasticity.
author:
- first_name: Nicholas
  full_name: Vyleta, Nicholas
  id: 36C4978E-F248-11E8-B48F-1D18A9856A87
  last_name: Vyleta
- first_name: Peter M
  full_name: Jonas, Peter M
  id: 353C1B58-F248-11E8-B48F-1D18A9856A87
  last_name: Jonas
  orcid: 0000-0001-5001-4804
citation:
  ama: Vyleta N, Jonas PM. Loose coupling between Ca^2+ channels and release sensors
    at a plastic hippocampal synapse. <i>Science</i>. 2014;343(6171):665-670. doi:<a
    href="https://doi.org/10.1126/science.1244811">10.1126/science.1244811</a>
  apa: Vyleta, N., &#38; Jonas, P. M. (2014). Loose coupling between Ca^2+ channels
    and release sensors at a plastic hippocampal synapse. <i>Science</i>. American
    Association for the Advancement of Science. <a href="https://doi.org/10.1126/science.1244811">https://doi.org/10.1126/science.1244811</a>
  chicago: Vyleta, Nicholas, and Peter M Jonas. “Loose Coupling between Ca^2+ Channels
    and Release Sensors at a Plastic Hippocampal Synapse.” <i>Science</i>. American
    Association for the Advancement of Science, 2014. <a href="https://doi.org/10.1126/science.1244811">https://doi.org/10.1126/science.1244811</a>.
  ieee: N. Vyleta and P. M. Jonas, “Loose coupling between Ca^2+ channels and release
    sensors at a plastic hippocampal synapse,” <i>Science</i>, vol. 343, no. 6171.
    American Association for the Advancement of Science, pp. 665–670, 2014.
  ista: Vyleta N, Jonas PM. 2014. Loose coupling between Ca^2+ channels and release
    sensors at a plastic hippocampal synapse. Science. 343(6171), 665–670.
  mla: Vyleta, Nicholas, and Peter M. Jonas. “Loose Coupling between Ca^2+ Channels
    and Release Sensors at a Plastic Hippocampal Synapse.” <i>Science</i>, vol. 343,
    no. 6171, American Association for the Advancement of Science, 2014, pp. 665–70,
    doi:<a href="https://doi.org/10.1126/science.1244811">10.1126/science.1244811</a>.
  short: N. Vyleta, P.M. Jonas, Science 343 (2014) 665–670.
date_created: 2018-12-11T11:56:27Z
date_published: 2014-02-01T00:00:00Z
date_updated: 2021-01-12T06:56:09Z
day: '01'
department:
- _id: PeJo
doi: 10.1126/science.1244811
ec_funded: 1
intvolume: '       343'
issue: '6171'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3617475/
month: '02'
oa: 1
oa_version: Submitted Version
page: 665 - 670
project:
- _id: 25C26B1E-B435-11E9-9278-68D0E5697425
  call_identifier: FWF
  grant_number: P24909-B24
  name: Mechanisms of transmitter release at GABAergic synapses
- _id: 25C0F108-B435-11E9-9278-68D0E5697425
  call_identifier: FP7
  grant_number: '268548'
  name: Nanophysiology of fast-spiking, parvalbumin-expressing GABAergic interneurons
publication: Science
publication_identifier:
  issn:
  - '00368075'
publication_status: published
publisher: American Association for the Advancement of Science
publist_id: '4732'
quality_controlled: '1'
scopus_import: 1
status: public
title: Loose coupling between Ca^2+ channels and release sensors at a plastic hippocampal
  synapse
type: journal_article
user_id: 4435EBFC-F248-11E8-B48F-1D18A9856A87
volume: 343
year: '2014'
...
---
_id: '2254'
abstract:
- lang: eng
  text: Theta-gamma network oscillations are thought to represent key reference signals
    for information processing in neuronal ensembles, but the underlying synaptic
    mechanisms remain unclear. To address this question, we performed whole-cell (WC)
    patch-clamp recordings from mature hippocampal granule cells (GCs) in vivo in
    the dentate gyrus of anesthetized and awake rats. GCs in vivo fired action potentials
    at low frequency, consistent with sparse coding in the dentate gyrus. GCs were
    exposed to barrages of fast AMPAR-mediated excitatory postsynaptic currents (EPSCs),
    primarily relayed from the entorhinal cortex, and inhibitory postsynaptic currents
    (IPSCs), presumably generated by local interneurons. EPSCs exhibited coherence
    with the field potential predominantly in the theta frequency band, whereas IPSCs
    showed coherence primarily in the gamma range. Action potentials in GCs were phase
    locked to network oscillations. Thus, theta-gamma-modulated synaptic currents
    may provide a framework for sparse temporal coding of information in the dentate
    gyrus.
author:
- first_name: Alejandro
  full_name: Pernia-Andrade, Alejandro
  id: 36963E98-F248-11E8-B48F-1D18A9856A87
  last_name: Pernia-Andrade
- first_name: Peter M
  full_name: Jonas, Peter M
  id: 353C1B58-F248-11E8-B48F-1D18A9856A87
  last_name: Jonas
  orcid: 0000-0001-5001-4804
citation:
  ama: Pernia-Andrade A, Jonas PM. Theta-gamma-modulated synaptic currents in hippocampal
    granule cells in vivo define a mechanism for network oscillations. <i>Neuron</i>.
    2014;81(1):140-152. doi:<a href="https://doi.org/10.1016/j.neuron.2013.09.046">10.1016/j.neuron.2013.09.046</a>
  apa: Pernia-Andrade, A., &#38; Jonas, P. M. (2014). Theta-gamma-modulated synaptic
    currents in hippocampal granule cells in vivo define a mechanism for network oscillations.
    <i>Neuron</i>. Elsevier. <a href="https://doi.org/10.1016/j.neuron.2013.09.046">https://doi.org/10.1016/j.neuron.2013.09.046</a>
  chicago: Pernia-Andrade, Alejandro, and Peter M Jonas. “Theta-Gamma-Modulated Synaptic
    Currents in Hippocampal Granule Cells in Vivo Define a Mechanism for Network Oscillations.”
    <i>Neuron</i>. Elsevier, 2014. <a href="https://doi.org/10.1016/j.neuron.2013.09.046">https://doi.org/10.1016/j.neuron.2013.09.046</a>.
  ieee: A. Pernia-Andrade and P. M. Jonas, “Theta-gamma-modulated synaptic currents
    in hippocampal granule cells in vivo define a mechanism for network oscillations,”
    <i>Neuron</i>, vol. 81, no. 1. Elsevier, pp. 140–152, 2014.
  ista: Pernia-Andrade A, Jonas PM. 2014. Theta-gamma-modulated synaptic currents
    in hippocampal granule cells in vivo define a mechanism for network oscillations.
    Neuron. 81(1), 140–152.
  mla: Pernia-Andrade, Alejandro, and Peter M. Jonas. “Theta-Gamma-Modulated Synaptic
    Currents in Hippocampal Granule Cells in Vivo Define a Mechanism for Network Oscillations.”
    <i>Neuron</i>, vol. 81, no. 1, Elsevier, 2014, pp. 140–52, doi:<a href="https://doi.org/10.1016/j.neuron.2013.09.046">10.1016/j.neuron.2013.09.046</a>.
  short: A. Pernia-Andrade, P.M. Jonas, Neuron 81 (2014) 140–152.
date_created: 2018-12-11T11:56:35Z
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title: Theta-gamma-modulated synaptic currents in hippocampal granule cells in vivo
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