[{"status":"public","intvolume":"       332","type":"journal_article","day":"01","page":"261 - 353","issue":"1","publication":"Communications in Mathematical Physics","language":[{"iso":"eng"}],"publisher":"Springer","scopus_import":1,"date_published":"2014-11-01T00:00:00Z","month":"11","date_created":"2018-12-11T11:54:48Z","department":[{"_id":"LaEr"}],"author":[{"last_name":"Bourgade","full_name":"Bourgade, Paul","first_name":"Paul"},{"id":"4DBD5372-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-5366-9603","full_name":"Erdös, László","last_name":"Erdös","first_name":"László"},{"full_name":"Yau, Horngtzer","last_name":"Yau","first_name":"Horngtzer"}],"abstract":[{"text":"We prove the edge universality of the beta ensembles for any β ≥ 1, provided that the limiting spectrum is supported on a single interval, and the external potential is C4 and regular. We also prove that the edge universality holds for generalized Wigner matrices for all symmetry classes. Moreover, our results allow us to extend bulk universality for beta ensembles from analytic potentials to potentials in class C4.","lang":"eng"}],"publication_status":"published","citation":{"mla":"Bourgade, Paul, et al. “Edge Universality of Beta Ensembles.” <i>Communications in Mathematical Physics</i>, vol. 332, no. 1, Springer, 2014, pp. 261–353, doi:<a href=\"https://doi.org/10.1007/s00220-014-2120-z\">10.1007/s00220-014-2120-z</a>.","ama":"Bourgade P, Erdös L, Yau H. Edge universality of beta ensembles. <i>Communications in Mathematical Physics</i>. 2014;332(1):261-353. doi:<a href=\"https://doi.org/10.1007/s00220-014-2120-z\">10.1007/s00220-014-2120-z</a>","short":"P. Bourgade, L. Erdös, H. Yau, Communications in Mathematical Physics 332 (2014) 261–353.","ista":"Bourgade P, Erdös L, Yau H. 2014. Edge universality of beta ensembles. Communications in Mathematical Physics. 332(1), 261–353.","apa":"Bourgade, P., Erdös, L., &#38; Yau, H. (2014). Edge universality of beta ensembles. <i>Communications in Mathematical Physics</i>. Springer. <a href=\"https://doi.org/10.1007/s00220-014-2120-z\">https://doi.org/10.1007/s00220-014-2120-z</a>","ieee":"P. Bourgade, L. Erdös, and H. Yau, “Edge universality of beta ensembles,” <i>Communications in Mathematical Physics</i>, vol. 332, no. 1. Springer, pp. 261–353, 2014.","chicago":"Bourgade, Paul, László Erdös, and Horngtzer Yau. “Edge Universality of Beta Ensembles.” <i>Communications in Mathematical Physics</i>. Springer, 2014. <a href=\"https://doi.org/10.1007/s00220-014-2120-z\">https://doi.org/10.1007/s00220-014-2120-z</a>."},"user_id":"4435EBFC-F248-11E8-B48F-1D18A9856A87","quality_controlled":"1","project":[{"grant_number":"SFB-TR3-TP10B","_id":"25BDE9A4-B435-11E9-9278-68D0E5697425","name":"Glutamaterge synaptische Übertragung und Plastizität in hippocampalen Mikroschaltkreisen"}],"oa_version":"Submitted Version","_id":"1937","volume":332,"publist_id":"5158","date_updated":"2021-01-12T06:54:12Z","oa":1,"title":"Edge universality of beta ensembles","doi":"10.1007/s00220-014-2120-z","year":"2014","main_file_link":[{"open_access":"1","url":"http://arxiv.org/abs/1306.5728"}]},{"type":"journal_article","day":"29","citation":{"mla":"Studer, Daniel, et al. “Capture of Activity-Induced Ultrastructural Changes at Synapses by High-Pressure Freezing of Brain Tissue.” <i>Nature Protocols</i>, vol. 9, no. 6, Nature Publishing Group, 2014, pp. 1480–95, doi:<a href=\"https://doi.org/10.1038/nprot.2014.099\">10.1038/nprot.2014.099</a>.","ama":"Studer D, Zhao S, Chai X, et al. Capture of activity-induced ultrastructural changes at synapses by high-pressure freezing of brain tissue. <i>Nature Protocols</i>. 2014;9(6):1480-1495. doi:<a href=\"https://doi.org/10.1038/nprot.2014.099\">10.1038/nprot.2014.099</a>","short":"D. Studer, S. Zhao, X. Chai, P.M. Jonas, W. Graber, S. Nestel, M. Frotscher, Nature Protocols 9 (2014) 1480–1495.","ista":"Studer D, Zhao S, Chai X, Jonas PM, Graber W, Nestel S, Frotscher M. 2014. Capture of activity-induced ultrastructural changes at synapses by high-pressure freezing of brain tissue. Nature Protocols. 9(6), 1480–1495.","apa":"Studer, D., Zhao, S., Chai, X., Jonas, P. M., Graber, W., Nestel, S., &#38; Frotscher, M. (2014). Capture of activity-induced ultrastructural changes at synapses by high-pressure freezing of brain tissue. <i>Nature Protocols</i>. Nature Publishing Group. <a href=\"https://doi.org/10.1038/nprot.2014.099\">https://doi.org/10.1038/nprot.2014.099</a>","ieee":"D. Studer <i>et al.</i>, “Capture of activity-induced ultrastructural changes at synapses by high-pressure freezing of brain tissue,” <i>Nature Protocols</i>, vol. 9, no. 6. Nature Publishing Group, pp. 1480–1495, 2014.","chicago":"Studer, Daniel, Shanting Zhao, Xuejun Chai, Peter M Jonas, Werner Graber, Sigrun Nestel, and Michael Frotscher. “Capture of Activity-Induced Ultrastructural Changes at Synapses by High-Pressure Freezing of Brain Tissue.” <i>Nature Protocols</i>. Nature Publishing Group, 2014. <a href=\"https://doi.org/10.1038/nprot.2014.099\">https://doi.org/10.1038/nprot.2014.099</a>."},"publication_status":"published","author":[{"first_name":"Daniel","last_name":"Studer","full_name":"Studer, Daniel"},{"first_name":"Shanting","last_name":"Zhao","full_name":"Zhao, Shanting"},{"last_name":"Chai","full_name":"Chai, Xuejun","first_name":"Xuejun"},{"id":"353C1B58-F248-11E8-B48F-1D18A9856A87","full_name":"Jonas, Peter M","last_name":"Jonas","orcid":"0000-0001-5001-4804","first_name":"Peter M"},{"last_name":"Graber","full_name":"Graber, Werner","first_name":"Werner"},{"last_name":"Nestel","full_name":"Nestel, Sigrun","first_name":"Sigrun"},{"first_name":"Michael","last_name":"Frotscher","full_name":"Frotscher, Michael"}],"status":"public","abstract":[{"text":"Electron microscopy (EM) allows for the simultaneous visualization of all tissue components at high resolution. However, the extent to which conventional aldehyde fixation and ethanol dehydration of the tissue alter the fine structure of cells and organelles, thereby preventing detection of subtle structural changes induced by an experiment, has remained an issue. Attempts have been made to rapidly freeze tissue to preserve native ultrastructure. Shock-freezing of living tissue under high pressure (high-pressure freezing, HPF) followed by cryosubstitution of the tissue water avoids aldehyde fixation and dehydration in ethanol; the tissue water is immobilized in â ̂1/450 ms, and a close-to-native fine structure of cells, organelles and molecules is preserved. Here we describe a protocol for HPF that is useful to monitor ultrastructural changes associated with functional changes at synapses in the brain but can be applied to many other tissues as well. The procedure requires a high-pressure freezer and takes a minimum of 7 d but can be paused at several points.","lang":"eng"}],"intvolume":"         9","page":"1480 - 1495","publist_id":"4807","volume":9,"date_updated":"2021-01-12T06:55:47Z","publication":"Nature Protocols","issue":"6","oa_version":"None","project":[{"grant_number":"SFB-TR3-TP10B","_id":"25BDE9A4-B435-11E9-9278-68D0E5697425","name":"Glutamaterge synaptische Übertragung und Plastizität in hippocampalen Mikroschaltkreisen"}],"quality_controlled":"1","user_id":"4435EBFC-F248-11E8-B48F-1D18A9856A87","_id":"2176","date_published":"2014-05-29T00:00:00Z","doi":"10.1038/nprot.2014.099","year":"2014","month":"05","language":[{"iso":"eng"}],"scopus_import":1,"title":"Capture of activity-induced ultrastructural changes at synapses by high-pressure freezing of brain tissue","publisher":"Nature Publishing Group","department":[{"_id":"PeJo"}],"date_created":"2018-12-11T11:56:09Z"},{"department":[{"_id":"BjHo"}],"date_created":"2018-12-11T11:56:26Z","month":"01","date_published":"2014-01-06T00:00:00Z","publisher":"American Institute of Physics","scopus_import":1,"language":[{"iso":"eng"}],"issue":"1","publication":"Physical Review E Statistical Nonlinear and Soft Matter Physics","day":"06","type":"journal_article","intvolume":"        89","status":"public","main_file_link":[{"url":"http://arxiv.org/abs/1312.5095","open_access":"1"}],"article_number":"013001","year":"2014","doi":"10.1103/PhysRevE.89.013001","title":"Transient growth of Ekman-Couette flow","oa":1,"date_updated":"2021-01-12T06:56:08Z","publist_id":"4737","volume":89,"_id":"2226","publication_identifier":{"issn":["15393755"]},"user_id":"4435EBFC-F248-11E8-B48F-1D18A9856A87","oa_version":"Submitted Version","project":[{"_id":"25BDE9A4-B435-11E9-9278-68D0E5697425","name":"Glutamaterge synaptische Übertragung und Plastizität in hippocampalen Mikroschaltkreisen","grant_number":"SFB-TR3-TP10B"}],"quality_controlled":"1","publication_status":"published","citation":{"ama":"Shi L, Hof B, Tilgner A. Transient growth of Ekman-Couette flow. <i>Physical Review E Statistical Nonlinear and Soft Matter Physics</i>. 2014;89(1). doi:<a href=\"https://doi.org/10.1103/PhysRevE.89.013001\">10.1103/PhysRevE.89.013001</a>","mla":"Shi, Liang, et al. “Transient Growth of Ekman-Couette Flow.” <i>Physical Review E Statistical Nonlinear and Soft Matter Physics</i>, vol. 89, no. 1, 013001, American Institute of Physics, 2014, doi:<a href=\"https://doi.org/10.1103/PhysRevE.89.013001\">10.1103/PhysRevE.89.013001</a>.","ista":"Shi L, Hof B, Tilgner A. 2014. Transient growth of Ekman-Couette flow. Physical Review E Statistical Nonlinear and Soft Matter Physics. 89(1), 013001.","short":"L. Shi, B. Hof, A. Tilgner, Physical Review E Statistical Nonlinear and Soft Matter Physics 89 (2014).","apa":"Shi, L., Hof, B., &#38; Tilgner, A. (2014). Transient growth of Ekman-Couette flow. <i>Physical Review E Statistical Nonlinear and Soft Matter Physics</i>. American Institute of Physics. <a href=\"https://doi.org/10.1103/PhysRevE.89.013001\">https://doi.org/10.1103/PhysRevE.89.013001</a>","ieee":"L. Shi, B. Hof, and A. Tilgner, “Transient growth of Ekman-Couette flow,” <i>Physical Review E Statistical Nonlinear and Soft Matter Physics</i>, vol. 89, no. 1. American Institute of Physics, 2014.","chicago":"Shi, Liang, Björn Hof, and Andreas Tilgner. “Transient Growth of Ekman-Couette Flow.” <i>Physical Review E Statistical Nonlinear and Soft Matter Physics</i>. American Institute of Physics, 2014. <a href=\"https://doi.org/10.1103/PhysRevE.89.013001\">https://doi.org/10.1103/PhysRevE.89.013001</a>."},"abstract":[{"lang":"eng","text":"Coriolis force effects on shear flows are important in geophysical and astrophysical contexts. We report a study on the linear stability and the transient energy growth of the plane Couette flow with system rotation perpendicular to the shear direction. External rotation causes linear instability. At small rotation rates, the onset of linear instability scales inversely with the rotation rate and the optimal transient growth in the linearly stable region is slightly enhanced ∼Re2. The corresponding optimal initial perturbations are characterized by roll structures inclined in the streamwise direction and are twisted under external rotation. At large rotation rates, the transient growth is significantly inhibited and hence linear stability analysis is a reliable indicator for instability."}],"author":[{"first_name":"Liang","full_name":"Shi, Liang","last_name":"Shi"},{"id":"3A374330-F248-11E8-B48F-1D18A9856A87","first_name":"Björn","orcid":"0000-0003-2057-2754","full_name":"Hof, Björn","last_name":"Hof"},{"full_name":"Tilgner, Andreas","last_name":"Tilgner","first_name":"Andreas"}]},{"volume":103,"date_updated":"2021-01-12T07:40:01Z","oa":1,"publist_id":"3774","quality_controlled":"1","oa_version":"Submitted Version","project":[{"grant_number":"SFB-TR3-TP10B","_id":"25BDE9A4-B435-11E9-9278-68D0E5697425","name":"Glutamaterge synaptische Übertragung und Plastizität in hippocampalen Mikroschaltkreisen"}],"acknowledgement":"This work was supported by the Deutsche Forschungsgemeinschaft (TR3/B10) and a European Research Council Advanced grant to P.J.\r\nWe thank H. Hu, S. J. Guzman, and C. Schmidt-Hieber for critically reading the manuscript, I. Koeva and F. Marr for technical support, and E. Kramberger for editorial assistance.\r\n","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","pmid":1,"_id":"2954","citation":{"ieee":"A. Pernia-Andrade, S. Goswami, Y. Stickler, U. Fröbe, A. Schlögl, and P. M. Jonas, “A deconvolution based method with high sensitivity and temporal resolution for detection of spontaneous synaptic currents in vitro and in vivo,” <i>Biophysical Journal</i>, vol. 103, no. 7. Biophysical, pp. 1429–1439, 2012.","apa":"Pernia-Andrade, A., Goswami, S., Stickler, Y., Fröbe, U., Schlögl, A., &#38; Jonas, P. M. (2012). A deconvolution based method with high sensitivity and temporal resolution for detection of spontaneous synaptic currents in vitro and in vivo. <i>Biophysical Journal</i>. Biophysical. <a href=\"https://doi.org/10.1016/j.bpj.2012.08.039\">https://doi.org/10.1016/j.bpj.2012.08.039</a>","chicago":"Pernia-Andrade, Alejandro, Sarit Goswami, Yvonne Stickler, Ulrich Fröbe, Alois Schlögl, and Peter M Jonas. “A Deconvolution Based Method with High Sensitivity and Temporal Resolution for Detection of Spontaneous Synaptic Currents in Vitro and in Vivo.” <i>Biophysical Journal</i>. Biophysical, 2012. <a href=\"https://doi.org/10.1016/j.bpj.2012.08.039\">https://doi.org/10.1016/j.bpj.2012.08.039</a>.","ama":"Pernia-Andrade A, Goswami S, Stickler Y, Fröbe U, Schlögl A, Jonas PM. A deconvolution based method with high sensitivity and temporal resolution for detection of spontaneous synaptic currents in vitro and in vivo. <i>Biophysical Journal</i>. 2012;103(7):1429-1439. doi:<a href=\"https://doi.org/10.1016/j.bpj.2012.08.039\">10.1016/j.bpj.2012.08.039</a>","mla":"Pernia-Andrade, Alejandro, et al. “A Deconvolution Based Method with High Sensitivity and Temporal Resolution for Detection of Spontaneous Synaptic Currents in Vitro and in Vivo.” <i>Biophysical Journal</i>, vol. 103, no. 7, Biophysical, 2012, pp. 1429–39, doi:<a href=\"https://doi.org/10.1016/j.bpj.2012.08.039\">10.1016/j.bpj.2012.08.039</a>.","ista":"Pernia-Andrade A, Goswami S, Stickler Y, Fröbe U, Schlögl A, Jonas PM. 2012. A deconvolution based method with high sensitivity and temporal resolution for detection of spontaneous synaptic currents in vitro and in vivo. Biophysical Journal. 103(7), 1429–1439.","short":"A. Pernia-Andrade, S. Goswami, Y. Stickler, U. Fröbe, A. Schlögl, P.M. Jonas, Biophysical Journal 103 (2012) 1429–1439."},"publication_status":"published","author":[{"full_name":"Pernia-Andrade, Alejandro","last_name":"Pernia-Andrade","first_name":"Alejandro","id":"36963E98-F248-11E8-B48F-1D18A9856A87"},{"id":"3A578F32-F248-11E8-B48F-1D18A9856A87","first_name":"Sarit","full_name":"Goswami, Sarit","last_name":"Goswami"},{"first_name":"Yvonne","last_name":"Stickler","full_name":"Stickler, Yvonne","id":"63B76600-E9CC-11E9-9B5F-82450873F7A1"},{"last_name":"Fröbe","full_name":"Fröbe, Ulrich","first_name":"Ulrich"},{"id":"45BF87EE-F248-11E8-B48F-1D18A9856A87","first_name":"Alois","last_name":"Schlögl","full_name":"Schlögl, Alois","orcid":"0000-0002-5621-8100"},{"id":"353C1B58-F248-11E8-B48F-1D18A9856A87","first_name":"Peter M","last_name":"Jonas","full_name":"Jonas, Peter M","orcid":"0000-0001-5001-4804"}],"abstract":[{"lang":"eng","text":"Spontaneous postsynaptic currents (PSCs) provide key information about the mechanisms of synaptic transmission and the activity modes of neuronal networks. However, detecting spontaneous PSCs in vitro and in vivo has been challenging, because of the small amplitude, the variable kinetics, and the undefined time of generation of these events. Here, we describe a, to our knowledge, new method for detecting spontaneous synaptic events by deconvolution, using a template that approximates the average time course of spontaneous PSCs. A recorded PSC trace is deconvolved from the template, resulting in a series of delta-like functions. The maxima of these delta-like events are reliably detected, revealing the precise onset times of the spontaneous PSCs. Among all detection methods, the deconvolution-based method has a unique temporal resolution, allowing the detection of individual events in high-frequency bursts. Furthermore, the deconvolution-based method has a high amplitude resolution, because deconvolution can substantially increase the signal/noise ratio. When tested against previously published methods using experimental data, the deconvolution-based method was superior for spontaneous PSCs recorded in vivo. Using the high-resolution deconvolution-based detection algorithm, we show that the frequency of spontaneous excitatory postsynaptic currents in dentate gyrus granule cells is 4.5 times higher in vivo than in vitro."}],"main_file_link":[{"url":"http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3471482/","open_access":"1"}],"year":"2012","doi":"10.1016/j.bpj.2012.08.039","title":"A deconvolution based method with high sensitivity and temporal resolution for detection of spontaneous synaptic currents in vitro and in vivo","external_id":{"pmid":["23062335"]},"page":"1429 - 1439","publication":"Biophysical Journal","issue":"7","type":"journal_article","day":"03","status":"public","intvolume":"       103","department":[{"_id":"PeJo"},{"_id":"ScienComp"}],"date_created":"2018-12-11T12:00:32Z","date_published":"2012-10-03T00:00:00Z","month":"10","language":[{"iso":"eng"}],"scopus_import":1,"publisher":"Biophysical"},{"year":"2012","doi":"10.1523/JNEUROSCI.6104-11.2012","external_id":{"pmid":["23055500"]},"title":"Miniature IPSCs in hippocampal granule cells are triggered by voltage-gated Ca^(2+) channels via microdomain coupling","main_file_link":[{"url":"http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3632771/","open_access":"1"}],"publication_status":"published","citation":{"chicago":"Goswami, Sarit, Iancu Bucurenciu, and Peter M Jonas. “Miniature IPSCs in Hippocampal Granule Cells Are Triggered by Voltage-Gated Ca^(2+) Channels via Microdomain Coupling.” <i>Journal of Neuroscience</i>. Society for Neuroscience, 2012. <a href=\"https://doi.org/10.1523/JNEUROSCI.6104-11.2012\">https://doi.org/10.1523/JNEUROSCI.6104-11.2012</a>.","apa":"Goswami, S., Bucurenciu, I., &#38; Jonas, P. M. (2012). Miniature IPSCs in hippocampal granule cells are triggered by voltage-gated Ca^(2+) channels via microdomain coupling. <i>Journal of Neuroscience</i>. Society for Neuroscience. <a href=\"https://doi.org/10.1523/JNEUROSCI.6104-11.2012\">https://doi.org/10.1523/JNEUROSCI.6104-11.2012</a>","ieee":"S. Goswami, I. Bucurenciu, and P. M. Jonas, “Miniature IPSCs in hippocampal granule cells are triggered by voltage-gated Ca^(2+) channels via microdomain coupling,” <i>Journal of Neuroscience</i>, vol. 32, no. 41. Society for Neuroscience, pp. 14294–14304, 2012.","ista":"Goswami S, Bucurenciu I, Jonas PM. 2012. Miniature IPSCs in hippocampal granule cells are triggered by voltage-gated Ca^(2+) channels via microdomain coupling. Journal of Neuroscience. 32(41), 14294–14304.","short":"S. Goswami, I. Bucurenciu, P.M. Jonas, Journal of Neuroscience 32 (2012) 14294–14304.","mla":"Goswami, Sarit, et al. “Miniature IPSCs in Hippocampal Granule Cells Are Triggered by Voltage-Gated Ca^(2+) Channels via Microdomain Coupling.” <i>Journal of Neuroscience</i>, vol. 32, no. 41, Society for Neuroscience, 2012, pp. 14294–304, doi:<a href=\"https://doi.org/10.1523/JNEUROSCI.6104-11.2012\">10.1523/JNEUROSCI.6104-11.2012</a>.","ama":"Goswami S, Bucurenciu I, Jonas PM. Miniature IPSCs in hippocampal granule cells are triggered by voltage-gated Ca^(2+) channels via microdomain coupling. <i>Journal of Neuroscience</i>. 2012;32(41):14294-14304. doi:<a href=\"https://doi.org/10.1523/JNEUROSCI.6104-11.2012\">10.1523/JNEUROSCI.6104-11.2012</a>"},"abstract":[{"text":"The coupling between presynaptic Ca^(2+) channels and Ca^(2+) sensors of exocytosis is a key determinant of synaptic transmission. Evoked release from parvalbumin (PV)-expressing interneurons is triggered by nanodomain coupling of P/Q-type Ca^(2+) channels, whereas release from cholecystokinin (CCK)-containing interneurons is generated by microdomain coupling of N-type channels. Nanodomain coupling has several functional advantages, including speed and efficacy of transmission. One potential disadvantage is that stochastic\r\nopening of presynaptic Ca^(2+) channels may trigger spontaneous transmitter release. We addressed this possibility in rat hippocampal\r\ngranule cells, which receive converging inputs from different inhibitory sources. Both reduction of extracellular Ca^(2+) concentration and the unselective Ca^(2+) channel blocker Cd^(2+) reduced the frequency of miniature IPSCs (mIPSCs) in granule cells by ~50%, suggesting that the opening of presynaptic Ca^(2+) channels contributes to spontaneous release. Application of the selective P/Q-type Ca^(2+) channel blocker\r\nω-agatoxin IVa had no detectable effects, whereas both the N-type blocker ω-conotoxin GVIa and the L-type blocker nimodipine reduced\r\nmIPSC frequency. Furthermore, both the fast Ca^(2+) chelator BAPTA-AM and the slow chelator EGTA-AM reduced the mIPSC frequency,\r\nsuggesting that Ca^(2+)-dependent spontaneous release is triggered by microdomain rather than nanodomain coupling. The CB_(1) receptor\r\nagonist WIN 55212-2 also decreased spontaneous release; this effect was occluded by prior application of ω-conotoxin GVIa, suggesting that a major fraction of Ca^(2+)-dependent spontaneous release was generated at the terminals of CCK-expressing interneurons. Tonic inhibition generated by spontaneous opening of presynaptic N- and L-type Ca^(2+) channels may be important for hippocampal information processing.\r\n","lang":"eng"}],"author":[{"last_name":"Goswami","full_name":"Goswami, Sarit","first_name":"Sarit","id":"3A578F32-F248-11E8-B48F-1D18A9856A87"},{"first_name":"Iancu","last_name":"Bucurenciu","full_name":"Bucurenciu, Iancu"},{"id":"353C1B58-F248-11E8-B48F-1D18A9856A87","last_name":"Jonas","full_name":"Jonas, Peter M","orcid":"0000-0001-5001-4804","first_name":"Peter M"}],"date_updated":"2021-01-12T07:40:08Z","oa":1,"publist_id":"3744","volume":32,"pmid":1,"_id":"2969","user_id":"3E5EF7F0-F248-11E8-B48F-1D18A9856A87","acknowledgement":"This work was supported by grants from the Deutsche Forschungsgemeinschaft (TR 3/B10, Leibniz program, GSC-4 Spemann Graduate School) and the European Union (European Research Council Advanced Grant).","project":[{"grant_number":"SFB-TR3-TP10B","_id":"25BDE9A4-B435-11E9-9278-68D0E5697425","name":"Glutamaterge synaptische Übertragung und Plastizität in hippocampalen Mikroschaltkreisen"}],"oa_version":"Submitted Version","quality_controlled":"1","month":"10","date_published":"2012-10-10T00:00:00Z","publisher":"Society for Neuroscience","scopus_import":1,"language":[{"iso":"eng"}],"department":[{"_id":"PeJo"}],"date_created":"2018-12-11T12:00:36Z","day":"10","type":"journal_article","intvolume":"        32","status":"public","issue":"41","publication":"Journal of Neuroscience","page":"14294 - 14304"},{"page":"600 - 606","issue":"4","publication":"Nature Neuroscience","type":"journal_article","day":"01","status":"public","intvolume":"        15","department":[{"_id":"PeJo"}],"date_created":"2018-12-11T12:02:18Z","date_published":"2012-04-01T00:00:00Z","article_type":"original","month":"04","language":[{"iso":"eng"}],"publisher":"Nature Publishing Group","scopus_import":"1","volume":15,"publist_id":"3390","date_updated":"2023-09-07T11:43:52Z","oa":1,"article_processing_charge":"No","user_id":"8b945eb4-e2f2-11eb-945a-df72226e66a9","acknowledgement":"This work was supported by the Deutsche Forschungsgemeinschaft (TR 3/B10) and the European Union (European Research Council Advanced grant to P.J.).","project":[{"grant_number":"SFB-TR3-TP10B","name":"Glutamaterge synaptische Übertragung und Plastizität in hippocampalen Mikroschaltkreisen","_id":"25BDE9A4-B435-11E9-9278-68D0E5697425"}],"oa_version":"Published Version","quality_controlled":"1","pmid":1,"_id":"3258","publication_identifier":{"issn":["1546-1726"]},"publication_status":"published","citation":{"ieee":"S. Kim, J. Guzmán, H. Hu, and P. M. Jonas, “Active dendrites support efficient initiation of dendritic spikes in hippocampal CA3 pyramidal neurons,” <i>Nature Neuroscience</i>, vol. 15, no. 4. Nature Publishing Group, pp. 600–606, 2012.","apa":"Kim, S., Guzmán, J., Hu, H., &#38; Jonas, P. M. (2012). Active dendrites support efficient initiation of dendritic spikes in hippocampal CA3 pyramidal neurons. <i>Nature Neuroscience</i>. Nature Publishing Group. <a href=\"https://doi.org/10.1038/nn.3060\">https://doi.org/10.1038/nn.3060</a>","chicago":"Kim, Sooyun, José Guzmán, Hua Hu, and Peter M Jonas. “Active Dendrites Support Efficient Initiation of Dendritic Spikes in Hippocampal CA3 Pyramidal Neurons.” <i>Nature Neuroscience</i>. Nature Publishing Group, 2012. <a href=\"https://doi.org/10.1038/nn.3060\">https://doi.org/10.1038/nn.3060</a>.","mla":"Kim, Sooyun, et al. “Active Dendrites Support Efficient Initiation of Dendritic Spikes in Hippocampal CA3 Pyramidal Neurons.” <i>Nature Neuroscience</i>, vol. 15, no. 4, Nature Publishing Group, 2012, pp. 600–06, doi:<a href=\"https://doi.org/10.1038/nn.3060\">10.1038/nn.3060</a>.","ama":"Kim S, Guzmán J, Hu H, Jonas PM. Active dendrites support efficient initiation of dendritic spikes in hippocampal CA3 pyramidal neurons. <i>Nature Neuroscience</i>. 2012;15(4):600-606. doi:<a href=\"https://doi.org/10.1038/nn.3060\">10.1038/nn.3060</a>","ista":"Kim S, Guzmán J, Hu H, Jonas PM. 2012. Active dendrites support efficient initiation of dendritic spikes in hippocampal CA3 pyramidal neurons. Nature Neuroscience. 15(4), 600–606.","short":"S. Kim, J. Guzmán, H. Hu, P.M. Jonas, Nature Neuroscience 15 (2012) 600–606."},"author":[{"id":"394AB1C8-F248-11E8-B48F-1D18A9856A87","last_name":"Kim","full_name":"Kim, Sooyun","first_name":"Sooyun"},{"orcid":"0000-0003-2209-5242","full_name":"Guzmán, José","last_name":"Guzmán","first_name":"José","id":"30CC5506-F248-11E8-B48F-1D18A9856A87"},{"first_name":"Hua","last_name":"Hu","full_name":"Hu, Hua","id":"4AC0145C-F248-11E8-B48F-1D18A9856A87"},{"id":"353C1B58-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-5001-4804","full_name":"Jonas, Peter M","last_name":"Jonas","first_name":"Peter M"}],"abstract":[{"lang":"eng","text":"CA3 pyramidal neurons are important for memory formation and pattern completion in the hippocampal network. It is generally thought that proximal synapses from the mossy fibers activate these neurons most efficiently, whereas distal inputs from the perforant path have a weaker modulatory influence. We used confocally targeted patch-clamp recording from dendrites and axons to map the activation of rat CA3 pyramidal neurons at the subcellular level. Our results reveal two distinct dendritic domains. In the proximal domain, action potentials initiated in the axon backpropagate actively with large amplitude and fast time course. In the distal domain, Na+ channel–mediated dendritic spikes are efficiently initiated by waveforms mimicking synaptic events. CA3 pyramidal neuron dendrites showed a high Na+-to-K+ conductance density ratio, providing ideal conditions for active backpropagation and dendritic spike initiation. Dendritic spikes may enhance the computational power of CA3 pyramidal neurons in the hippocampal network."}],"main_file_link":[{"url":"http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3617474/","open_access":"1"}],"related_material":{"record":[{"status":"public","id":"2964","relation":"dissertation_contains"}]},"year":"2012","doi":"10.1038/nn.3060","title":"Active dendrites support efficient initiation of dendritic spikes in hippocampal CA3 pyramidal neurons","external_id":{"pmid":["22388958"]}},{"ddc":["570"],"year":"2012","doi":"10.1038/nrn3125","title":"Nanodomain coupling between Ca(2+) channels and sensors of exocytosis at fast mammalian synapses","pubrep_id":"820","oa":1,"publist_id":"3322","date_updated":"2021-01-12T07:42:36Z","volume":13,"_id":"3317","quality_controlled":"1","oa_version":"Submitted Version","project":[{"name":"Synaptic Mechanisms of Neuronal Network Function","_id":"25BC64A8-B435-11E9-9278-68D0E5697425","grant_number":"JO_780/A5"},{"grant_number":"SFB-TR3-TP10B","_id":"25BDE9A4-B435-11E9-9278-68D0E5697425","name":"Glutamaterge synaptische Übertragung und Plastizität in hippocampalen Mikroschaltkreisen"}],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","acknowledgement":"Work of the authors was funded by grants of the Deutsche Forschungsgemeinschaft to P.J. (grants SFB 780/A5, TR 3/B10 and the Leibniz programme), a European Research Council Advanced grant to P.J. and a Swiss National Foundation fellowship to E.E.\r\nWe thank D. Tsien and E. Neher for their comments on this Review, J. Guzmán and A. Pernía-Andrade for reading earlier versions and E. Kramberger for perfect editorial support. We apologize that owing to space constraints, not all relevant papers could be cited.\r\n","citation":{"ista":"Eggermann E, Bucurenciu I, Goswami S, Jonas PM. 2012. Nanodomain coupling between Ca(2+) channels and sensors of exocytosis at fast mammalian synapses. Nature Reviews Neuroscience. 13(1), 7–21.","short":"E. Eggermann, I. Bucurenciu, S. Goswami, P.M. Jonas, Nature Reviews Neuroscience 13 (2012) 7–21.","ama":"Eggermann E, Bucurenciu I, Goswami S, Jonas PM. Nanodomain coupling between Ca(2+) channels and sensors of exocytosis at fast mammalian synapses. <i>Nature Reviews Neuroscience</i>. 2012;13(1):7-21. doi:<a href=\"https://doi.org/10.1038/nrn3125\">10.1038/nrn3125</a>","mla":"Eggermann, Emmanuel, et al. “Nanodomain Coupling between Ca(2+) Channels and Sensors of Exocytosis at Fast Mammalian Synapses.” <i>Nature Reviews Neuroscience</i>, vol. 13, no. 1, Nature Publishing Group, 2012, pp. 7–21, doi:<a href=\"https://doi.org/10.1038/nrn3125\">10.1038/nrn3125</a>.","chicago":"Eggermann, Emmanuel, Iancu Bucurenciu, Sarit Goswami, and Peter M Jonas. “Nanodomain Coupling between Ca(2+) Channels and Sensors of Exocytosis at Fast Mammalian Synapses.” <i>Nature Reviews Neuroscience</i>. Nature Publishing Group, 2012. <a href=\"https://doi.org/10.1038/nrn3125\">https://doi.org/10.1038/nrn3125</a>.","apa":"Eggermann, E., Bucurenciu, I., Goswami, S., &#38; Jonas, P. M. (2012). Nanodomain coupling between Ca(2+) channels and sensors of exocytosis at fast mammalian synapses. <i>Nature Reviews Neuroscience</i>. Nature Publishing Group. <a href=\"https://doi.org/10.1038/nrn3125\">https://doi.org/10.1038/nrn3125</a>","ieee":"E. Eggermann, I. Bucurenciu, S. Goswami, and P. M. Jonas, “Nanodomain coupling between Ca(2+) channels and sensors of exocytosis at fast mammalian synapses,” <i>Nature Reviews Neuroscience</i>, vol. 13, no. 1. Nature Publishing Group, pp. 7–21, 2012."},"publication_status":"published","abstract":[{"text":"The physical distance between presynaptic Ca2+ channels and the Ca2+ sensors that trigger exocytosis of neurotransmitter-containing vesicles is a key determinant of the signalling properties of synapses in the nervous system. Recent functional analysis indicates that in some fast central synapses, transmitter release is triggered by a small number of Ca2+ channels that are coupled to Ca2+ sensors at the nanometre scale. Molecular analysis suggests that this tight coupling is generated by protein–protein interactions involving Ca2+ channels, Ca2+ sensors and various other synaptic proteins. Nanodomain coupling has several functional advantages, as it increases the efficacy, speed and energy efficiency of synaptic transmission.","lang":"eng"}],"author":[{"id":"34DACA34-E9AE-11E9-849C-D35BD8ADC20C","first_name":"Emmanuel","last_name":"Eggermann","full_name":"Eggermann, Emmanuel"},{"id":"4BD1D872-E9AE-11E9-9EE9-8BF4597A9E2A","first_name":"Iancu","full_name":"Bucurenciu, Iancu","last_name":"Bucurenciu"},{"full_name":"Goswami, Sarit","last_name":"Goswami","first_name":"Sarit","id":"3A578F32-F248-11E8-B48F-1D18A9856A87"},{"id":"353C1B58-F248-11E8-B48F-1D18A9856A87","first_name":"Peter M","last_name":"Jonas","full_name":"Jonas, Peter M","orcid":"0000-0001-5001-4804"}],"has_accepted_license":"1","department":[{"_id":"PeJo"}],"file":[{"creator":"system","file_id":"4931","relation":"main_file","content_type":"application/pdf","checksum":"4c1c86b2f6e4e1562f5bb800b457ea9f","date_created":"2018-12-12T10:12:13Z","file_size":314246,"file_name":"IST-2017-820-v1+1_17463_3_art_file_109404_ltmxbw.pdf","access_level":"open_access","date_updated":"2020-07-14T12:46:07Z"},{"date_updated":"2020-07-14T12:46:07Z","access_level":"open_access","file_name":"IST-2017-820-v1+2_17463_3_figure_109402_ltmwlp.pdf","file_size":1840216,"date_created":"2018-12-12T10:12:14Z","checksum":"bceb2efdd49d115f4dde8486bc1be3f2","content_type":"application/pdf","relation":"main_file","file_id":"4932","creator":"system"}],"date_created":"2018-12-11T12:02:38Z","month":"01","date_published":"2012-01-01T00:00:00Z","scopus_import":1,"publisher":"Nature Publishing Group","language":[{"iso":"eng"}],"publication":"Nature Reviews Neuroscience","issue":"1","file_date_updated":"2020-07-14T12:46:07Z","page":"7 - 21","day":"01","type":"journal_article","intvolume":"        13","status":"public"}]