---
_id: '3317'
abstract:
- lang: eng
  text: The physical distance between presynaptic Ca2+ channels and the Ca2+ sensors
    that trigger exocytosis of neurotransmitter-containing vesicles is a key determinant
    of the signalling properties of synapses in the nervous system. Recent functional
    analysis indicates that in some fast central synapses, transmitter release is
    triggered by a small number of Ca2+ channels that are coupled to Ca2+ sensors
    at the nanometre scale. Molecular analysis suggests that this tight coupling is
    generated by protein–protein interactions involving Ca2+ channels, Ca2+ sensors
    and various other synaptic proteins. Nanodomain coupling has several functional
    advantages, as it increases the efficacy, speed and energy efficiency of synaptic
    transmission.
acknowledgement: "Work of the authors was funded by grants of the Deutsche Forschungsgemeinschaft
  to P.J. (grants SFB 780/A5, TR 3/B10 and the Leibniz programme), a European Research
  Council Advanced grant to P.J. and a Swiss National Foundation fellowship to E.E.\r\nWe
  thank D. Tsien and E. Neher for their comments on this Review, J. Guzmán and A.
  Pernía-Andrade for reading earlier versions and E. Kramberger for perfect editorial
  support. We apologize that owing to space constraints, not all relevant papers could
  be cited.\r\n"
author:
- first_name: Emmanuel
  full_name: Eggermann, Emmanuel
  id: 34DACA34-E9AE-11E9-849C-D35BD8ADC20C
  last_name: Eggermann
- first_name: Iancu
  full_name: Bucurenciu, Iancu
  id: 4BD1D872-E9AE-11E9-9EE9-8BF4597A9E2A
  last_name: Bucurenciu
- first_name: Sarit
  full_name: Goswami, Sarit
  id: 3A578F32-F248-11E8-B48F-1D18A9856A87
  last_name: Goswami
- first_name: Peter M
  full_name: Jonas, Peter M
  id: 353C1B58-F248-11E8-B48F-1D18A9856A87
  last_name: Jonas
  orcid: 0000-0001-5001-4804
citation:
  ama: Eggermann E, Bucurenciu I, Goswami S, Jonas PM. Nanodomain coupling between
    Ca(2+) channels and sensors of exocytosis at fast mammalian synapses. <i>Nature
    Reviews Neuroscience</i>. 2012;13(1):7-21. doi:<a href="https://doi.org/10.1038/nrn3125">10.1038/nrn3125</a>
  apa: Eggermann, E., Bucurenciu, I., Goswami, S., &#38; Jonas, P. M. (2012). Nanodomain
    coupling between Ca(2+) channels and sensors of exocytosis at fast mammalian synapses.
    <i>Nature Reviews Neuroscience</i>. Nature Publishing Group. <a href="https://doi.org/10.1038/nrn3125">https://doi.org/10.1038/nrn3125</a>
  chicago: Eggermann, Emmanuel, Iancu Bucurenciu, Sarit Goswami, and Peter M Jonas.
    “Nanodomain Coupling between Ca(2+) Channels and Sensors of Exocytosis at Fast
    Mammalian Synapses.” <i>Nature Reviews Neuroscience</i>. Nature Publishing Group,
    2012. <a href="https://doi.org/10.1038/nrn3125">https://doi.org/10.1038/nrn3125</a>.
  ieee: E. Eggermann, I. Bucurenciu, S. Goswami, and P. M. Jonas, “Nanodomain coupling
    between Ca(2+) channels and sensors of exocytosis at fast mammalian synapses,”
    <i>Nature Reviews Neuroscience</i>, vol. 13, no. 1. Nature Publishing Group, pp.
    7–21, 2012.
  ista: Eggermann E, Bucurenciu I, Goswami S, Jonas PM. 2012. Nanodomain coupling
    between Ca(2+) channels and sensors of exocytosis at fast mammalian synapses.
    Nature Reviews Neuroscience. 13(1), 7–21.
  mla: Eggermann, Emmanuel, et al. “Nanodomain Coupling between Ca(2+) Channels and
    Sensors of Exocytosis at Fast Mammalian Synapses.” <i>Nature Reviews Neuroscience</i>,
    vol. 13, no. 1, Nature Publishing Group, 2012, pp. 7–21, doi:<a href="https://doi.org/10.1038/nrn3125">10.1038/nrn3125</a>.
  short: E. Eggermann, I. Bucurenciu, S. Goswami, P.M. Jonas, Nature Reviews Neuroscience
    13 (2012) 7–21.
date_created: 2018-12-11T12:02:38Z
date_published: 2012-01-01T00:00:00Z
date_updated: 2021-01-12T07:42:36Z
day: '01'
ddc:
- '570'
department:
- _id: PeJo
doi: 10.1038/nrn3125
file:
- access_level: open_access
  checksum: 4c1c86b2f6e4e1562f5bb800b457ea9f
  content_type: application/pdf
  creator: system
  date_created: 2018-12-12T10:12:13Z
  date_updated: 2020-07-14T12:46:07Z
  file_id: '4931'
  file_name: IST-2017-820-v1+1_17463_3_art_file_109404_ltmxbw.pdf
  file_size: 314246
  relation: main_file
- access_level: open_access
  checksum: bceb2efdd49d115f4dde8486bc1be3f2
  content_type: application/pdf
  creator: system
  date_created: 2018-12-12T10:12:14Z
  date_updated: 2020-07-14T12:46:07Z
  file_id: '4932'
  file_name: IST-2017-820-v1+2_17463_3_figure_109402_ltmwlp.pdf
  file_size: 1840216
  relation: main_file
file_date_updated: 2020-07-14T12:46:07Z
has_accepted_license: '1'
intvolume: '        13'
issue: '1'
language:
- iso: eng
month: '01'
oa: 1
oa_version: Submitted Version
page: 7 - 21
project:
- _id: 25BC64A8-B435-11E9-9278-68D0E5697425
  grant_number: JO_780/A5
  name: Synaptic Mechanisms of Neuronal Network Function
- _id: 25BDE9A4-B435-11E9-9278-68D0E5697425
  grant_number: SFB-TR3-TP10B
  name: Glutamaterge synaptische Übertragung und Plastizität in hippocampalen Mikroschaltkreisen
publication: Nature Reviews Neuroscience
publication_status: published
publisher: Nature Publishing Group
publist_id: '3322'
pubrep_id: '820'
quality_controlled: '1'
scopus_import: 1
status: public
title: Nanodomain coupling between Ca(2+) channels and sensors of exocytosis at fast
  mammalian synapses
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 13
year: '2012'
...