[{"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","date_updated":"2021-01-12T07:42:36Z","scopus_import":1,"year":"2012","oa_version":"Submitted Version","has_accepted_license":"1","publist_id":"3322","volume":13,"pubrep_id":"820","file_date_updated":"2020-07-14T12:46:07Z","oa":1,"publication_status":"published","_id":"3317","abstract":[{"lang":"eng","text":"The physical distance between presynaptic Ca2+ channels and the Ca2+ sensors that trigger exocytosis of neurotransmitter-containing vesicles is a key determinant of the signalling properties of synapses in the nervous system. Recent functional analysis indicates that in some fast central synapses, transmitter release is triggered by a small number of Ca2+ channels that are coupled to Ca2+ sensors at the nanometre scale. Molecular analysis suggests that this tight coupling is generated by protein–protein interactions involving Ca2+ channels, Ca2+ sensors and various other synaptic proteins. Nanodomain coupling has several functional advantages, as it increases the efficacy, speed and energy efficiency of synaptic transmission."}],"date_published":"2012-01-01T00:00:00Z","file":[{"date_created":"2018-12-12T10:12:13Z","relation":"main_file","file_id":"4931","content_type":"application/pdf","checksum":"4c1c86b2f6e4e1562f5bb800b457ea9f","access_level":"open_access","date_updated":"2020-07-14T12:46:07Z","creator":"system","file_size":314246,"file_name":"IST-2017-820-v1+1_17463_3_art_file_109404_ltmxbw.pdf"},{"access_level":"open_access","date_updated":"2020-07-14T12:46:07Z","checksum":"bceb2efdd49d115f4dde8486bc1be3f2","creator":"system","file_size":1840216,"file_name":"IST-2017-820-v1+2_17463_3_figure_109402_ltmwlp.pdf","date_created":"2018-12-12T10:12:14Z","relation":"main_file","file_id":"4932","content_type":"application/pdf"}],"issue":"1","ddc":["570"],"doi":"10.1038/nrn3125","language":[{"iso":"eng"}],"acknowledgement":"Work of the authors was funded by grants of the Deutsche Forschungsgemeinschaft to P.J. (grants SFB 780/A5, TR 3/B10 and the Leibniz programme), a European Research Council Advanced grant to P.J. and a Swiss National Foundation fellowship to E.E.\r\nWe thank D. Tsien and E. Neher for their comments on this Review, J. Guzmán and A. Pernía-Andrade for reading earlier versions and E. Kramberger for perfect editorial support. We apologize that owing to space constraints, not all relevant papers could be cited.\r\n","project":[{"_id":"25BC64A8-B435-11E9-9278-68D0E5697425","grant_number":"JO_780/A5","name":"Synaptic Mechanisms of Neuronal Network Function"},{"grant_number":"SFB-TR3-TP10B","name":"Glutamaterge synaptische Übertragung und Plastizität in hippocampalen Mikroschaltkreisen","_id":"25BDE9A4-B435-11E9-9278-68D0E5697425"}],"type":"journal_article","author":[{"last_name":"Eggermann","full_name":"Eggermann, Emmanuel","first_name":"Emmanuel","id":"34DACA34-E9AE-11E9-849C-D35BD8ADC20C"},{"id":"4BD1D872-E9AE-11E9-9EE9-8BF4597A9E2A","last_name":"Bucurenciu","first_name":"Iancu","full_name":"Bucurenciu, Iancu"},{"last_name":"Goswami","full_name":"Goswami, Sarit","first_name":"Sarit","id":"3A578F32-F248-11E8-B48F-1D18A9856A87"},{"last_name":"Jonas","first_name":"Peter M","full_name":"Jonas, Peter M","orcid":"0000-0001-5001-4804","id":"353C1B58-F248-11E8-B48F-1D18A9856A87"}],"day":"01","title":"Nanodomain coupling between Ca(2+) channels and sensors of exocytosis at fast mammalian synapses","citation":{"ama":"Eggermann E, Bucurenciu I, Goswami S, Jonas PM. Nanodomain coupling between Ca(2+) channels and sensors of exocytosis at fast mammalian synapses. <i>Nature Reviews Neuroscience</i>. 2012;13(1):7-21. doi:<a href=\"https://doi.org/10.1038/nrn3125\">10.1038/nrn3125</a>","apa":"Eggermann, E., Bucurenciu, I., Goswami, S., &#38; Jonas, P. M. (2012). Nanodomain coupling between Ca(2+) channels and sensors of exocytosis at fast mammalian synapses. <i>Nature Reviews Neuroscience</i>. Nature Publishing Group. <a href=\"https://doi.org/10.1038/nrn3125\">https://doi.org/10.1038/nrn3125</a>","short":"E. Eggermann, I. Bucurenciu, S. Goswami, P.M. Jonas, Nature Reviews Neuroscience 13 (2012) 7–21.","mla":"Eggermann, Emmanuel, et al. “Nanodomain Coupling between Ca(2+) Channels and Sensors of Exocytosis at Fast Mammalian Synapses.” <i>Nature Reviews Neuroscience</i>, vol. 13, no. 1, Nature Publishing Group, 2012, pp. 7–21, doi:<a href=\"https://doi.org/10.1038/nrn3125\">10.1038/nrn3125</a>.","chicago":"Eggermann, Emmanuel, Iancu Bucurenciu, Sarit Goswami, and Peter M Jonas. “Nanodomain Coupling between Ca(2+) Channels and Sensors of Exocytosis at Fast Mammalian Synapses.” <i>Nature Reviews Neuroscience</i>. Nature Publishing Group, 2012. <a href=\"https://doi.org/10.1038/nrn3125\">https://doi.org/10.1038/nrn3125</a>.","ieee":"E. Eggermann, I. Bucurenciu, S. Goswami, and P. M. Jonas, “Nanodomain coupling between Ca(2+) channels and sensors of exocytosis at fast mammalian synapses,” <i>Nature Reviews Neuroscience</i>, vol. 13, no. 1. Nature Publishing Group, pp. 7–21, 2012.","ista":"Eggermann E, Bucurenciu I, Goswami S, Jonas PM. 2012. Nanodomain coupling between Ca(2+) channels and sensors of exocytosis at fast mammalian synapses. Nature Reviews Neuroscience. 13(1), 7–21."},"intvolume":"        13","status":"public","department":[{"_id":"PeJo"}],"quality_controlled":"1","publication":"Nature Reviews Neuroscience","publisher":"Nature Publishing Group","date_created":"2018-12-11T12:02:38Z","month":"01","page":"7 - 21"}]