@article{3317,
  abstract     = {The physical distance between presynaptic Ca2+ channels and the Ca2+ sensors that trigger exocytosis of neurotransmitter-containing vesicles is a key determinant of the signalling properties of synapses in the nervous system. Recent functional analysis indicates that in some fast central synapses, transmitter release is triggered by a small number of Ca2+ channels that are coupled to Ca2+ sensors at the nanometre scale. Molecular analysis suggests that this tight coupling is generated by protein–protein interactions involving Ca2+ channels, Ca2+ sensors and various other synaptic proteins. Nanodomain coupling has several functional advantages, as it increases the efficacy, speed and energy efficiency of synaptic transmission.},
  author       = {Eggermann, Emmanuel and Bucurenciu, Iancu and Goswami, Sarit and Jonas, Peter M},
  journal      = {Nature Reviews Neuroscience},
  number       = {1},
  pages        = {7 -- 21},
  publisher    = {Nature Publishing Group},
  title        = {{Nanodomain coupling between Ca(2+) channels and sensors of exocytosis at fast mammalian synapses}},
  doi          = {10.1038/nrn3125},
  volume       = {13},
  year         = {2012},
}