---
_id: '1241'
abstract:
- lang: eng
  text: 'How likely is it that a population escapes extinction through adaptive evolution?
    The answer to this question is of great relevance in conservation biology, where
    we aim at species’ rescue and the maintenance of biodiversity, and in agriculture
    and medicine, where we seek to hamper the emergence of pesticide or drug resistance.
    By reshuffling the genome, recombination has two antagonistic effects on the probability
    of evolutionary rescue: It generates and it breaks up favorable gene combinations.
    Which of the two effects prevails depends on the fitness effects of mutations
    and on the impact of stochasticity on the allele frequencies. In this article,
    we analyze a mathematical model for rescue after a sudden environmental change
    when adaptation is contingent on mutations at two loci. The analysis reveals a
    complex nonlinear dependence of population survival on recombination. We moreover
    find that, counterintuitively, a fast eradication of the wild type can promote
    rescue in the presence of recombination. The model also shows that two-step rescue
    is not unlikely to happen and can even be more likely than single-step rescue
    (where adaptation relies on a single mutation), depending on the circumstances.'
acknowledgement: This work was made possible by a “For Women in Science” fellowship
  (L’Oréal Österreich in cooperation with the Austrian Commission for the United Nations
  Educational, Scientific, and Cultural Organization and the Austrian Academy of Sciences
  with financial support from the Federal Ministry for Science and Research Austria)
  and European Research Council grant 250152 (to Nick Barton).
author:
- first_name: Hildegard
  full_name: Uecker, Hildegard
  id: 2DB8F68A-F248-11E8-B48F-1D18A9856A87
  last_name: Uecker
  orcid: 0000-0001-9435-2813
- first_name: Joachim
  full_name: Hermisson, Joachim
  last_name: Hermisson
citation:
  ama: Uecker H, Hermisson J. The role of recombination in evolutionary rescue. <i>Genetics</i>.
    2016;202(2):721-732. doi:<a href="https://doi.org/10.1534/genetics.115.180299">10.1534/genetics.115.180299</a>
  apa: Uecker, H., &#38; Hermisson, J. (2016). The role of recombination in evolutionary
    rescue. <i>Genetics</i>. Genetics Society of America. <a href="https://doi.org/10.1534/genetics.115.180299">https://doi.org/10.1534/genetics.115.180299</a>
  chicago: Uecker, Hildegard, and Joachim Hermisson. “The Role of Recombination in
    Evolutionary Rescue.” <i>Genetics</i>. Genetics Society of America, 2016. <a href="https://doi.org/10.1534/genetics.115.180299">https://doi.org/10.1534/genetics.115.180299</a>.
  ieee: H. Uecker and J. Hermisson, “The role of recombination in evolutionary rescue,”
    <i>Genetics</i>, vol. 202, no. 2. Genetics Society of America, pp. 721–732, 2016.
  ista: Uecker H, Hermisson J. 2016. The role of recombination in evolutionary rescue.
    Genetics. 202(2), 721–732.
  mla: Uecker, Hildegard, and Joachim Hermisson. “The Role of Recombination in Evolutionary
    Rescue.” <i>Genetics</i>, vol. 202, no. 2, Genetics Society of America, 2016,
    pp. 721–32, doi:<a href="https://doi.org/10.1534/genetics.115.180299">10.1534/genetics.115.180299</a>.
  short: H. Uecker, J. Hermisson, Genetics 202 (2016) 721–732.
date_created: 2018-12-11T11:50:54Z
date_published: 2016-02-01T00:00:00Z
date_updated: 2023-02-21T10:24:19Z
day: '01'
department:
- _id: NiBa
doi: 10.1534/genetics.115.180299
ec_funded: 1
intvolume: '       202'
issue: '2'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: http://biorxiv.org/content/early/2015/07/06/022020.abstract
month: '02'
oa: 1
oa_version: Preprint
page: 721 - 732
project:
- _id: 25B07788-B435-11E9-9278-68D0E5697425
  call_identifier: FP7
  grant_number: '250152'
  name: Limits to selection in biology and in evolutionary computation
- _id: 25B67606-B435-11E9-9278-68D0E5697425
  name: L'OREAL Fellowship
publication: Genetics
publication_status: published
publisher: Genetics Society of America
publist_id: '6091'
quality_controlled: '1'
scopus_import: 1
status: public
title: The role of recombination in evolutionary rescue
type: journal_article
user_id: 3E5EF7F0-F248-11E8-B48F-1D18A9856A87
volume: 202
year: '2016'
...
---
_id: '1699'
abstract:
- lang: eng
  text: By hybridization and backcrossing, alleles can surmount species boundaries
    and be incorporated into the genome of a related species. This introgression of
    genes is of particular evolutionary relevance if it involves the transfer of adaptations
    between populations. However, any beneficial allele will typically be associated
    with other alien alleles that are often deleterious and hamper the introgression
    process. In order to describe the introgression of an adaptive allele, we set
    up a stochastic model with an explicit genetic makeup of linked and unlinked deleterious
    alleles. Based on the theory of reducible multitype branching processes, we derive
    a recursive expression for the establishment probability of the beneficial allele
    after a single hybridization event. We furthermore study the probability that
    slightly deleterious alleles hitchhike to fixation. The key to the analysis is
    a split of the process into a stochastic phase in which the advantageous alleles
    establishes and a deterministic phase in which it sweeps to fixation. We thereafter
    apply the theory to a set of biologically relevant scenarios such as introgression
    in the presence of many unlinked or few closely linked deleterious alleles. A
    comparison to computer simulations shows that the approximations work well over
    a large parameter range.
acknowledgement: This work was made possible with financial support by the Vienna
  Science and Technology Fund (WWTF), by the Deutsche Forschungsgemeinschaft (DFG),
  Research Unit 1078 Natural selection in structured populations, by the Austrian
  Science Fund (FWF) via funding for the Vienna Graduate School for Population Genetics,
  and by a “For Women in Science” fellowship (L’Oréal Österreich in cooperation with
  the Austrian Commission for UNESCO and the Austrian Academy of Sciences with financial
  support from the Federal Ministry for Science and Research Austria).
author:
- first_name: Hildegard
  full_name: Uecker, Hildegard
  id: 2DB8F68A-F248-11E8-B48F-1D18A9856A87
  last_name: Uecker
  orcid: 0000-0001-9435-2813
- first_name: Derek
  full_name: Setter, Derek
  last_name: Setter
- first_name: Joachim
  full_name: Hermisson, Joachim
  last_name: Hermisson
citation:
  ama: Uecker H, Setter D, Hermisson J. Adaptive gene introgression after secondary
    contact. <i>Journal of Mathematical Biology</i>. 2015;70(7):1523-1580. doi:<a
    href="https://doi.org/10.1007/s00285-014-0802-y">10.1007/s00285-014-0802-y</a>
  apa: Uecker, H., Setter, D., &#38; Hermisson, J. (2015). Adaptive gene introgression
    after secondary contact. <i>Journal of Mathematical Biology</i>. Springer. <a
    href="https://doi.org/10.1007/s00285-014-0802-y">https://doi.org/10.1007/s00285-014-0802-y</a>
  chicago: Uecker, Hildegard, Derek Setter, and Joachim Hermisson. “Adaptive Gene
    Introgression after Secondary Contact.” <i>Journal of Mathematical Biology</i>.
    Springer, 2015. <a href="https://doi.org/10.1007/s00285-014-0802-y">https://doi.org/10.1007/s00285-014-0802-y</a>.
  ieee: H. Uecker, D. Setter, and J. Hermisson, “Adaptive gene introgression after
    secondary contact,” <i>Journal of Mathematical Biology</i>, vol. 70, no. 7. Springer,
    pp. 1523–1580, 2015.
  ista: Uecker H, Setter D, Hermisson J. 2015. Adaptive gene introgression after secondary
    contact. Journal of Mathematical Biology. 70(7), 1523–1580.
  mla: Uecker, Hildegard, et al. “Adaptive Gene Introgression after Secondary Contact.”
    <i>Journal of Mathematical Biology</i>, vol. 70, no. 7, Springer, 2015, pp. 1523–80,
    doi:<a href="https://doi.org/10.1007/s00285-014-0802-y">10.1007/s00285-014-0802-y</a>.
  short: H. Uecker, D. Setter, J. Hermisson, Journal of Mathematical Biology 70 (2015)
    1523–1580.
date_created: 2018-12-11T11:53:32Z
date_published: 2015-06-01T00:00:00Z
date_updated: 2023-02-23T10:10:36Z
day: '01'
ddc:
- '576'
department:
- _id: NiBa
doi: 10.1007/s00285-014-0802-y
file:
- access_level: open_access
  checksum: 00e3a67bda05d4cc165b3a48b41ef9ad
  content_type: application/pdf
  creator: system
  date_created: 2018-12-12T10:14:27Z
  date_updated: 2020-07-14T12:45:12Z
  file_id: '5079'
  file_name: IST-2016-458-v1+1_s00285-014-0802-y.pdf
  file_size: 1321527
  relation: main_file
file_date_updated: 2020-07-14T12:45:12Z
has_accepted_license: '1'
intvolume: '        70'
issue: '7'
language:
- iso: eng
month: '06'
oa: 1
oa_version: Published Version
page: 1523 - 1580
project:
- _id: 25B67606-B435-11E9-9278-68D0E5697425
  name: L'OREAL Fellowship
publication: Journal of Mathematical Biology
publication_status: published
publisher: Springer
publist_id: '5442'
pubrep_id: '458'
quality_controlled: '1'
scopus_import: 1
status: public
title: Adaptive gene introgression after secondary contact
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 70
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...