[{"department":[{"_id":"NiBa"}],"month":"02","citation":{"apa":"Uecker, H., &#38; Hermisson, J. (2016). The role of recombination in evolutionary rescue. <i>Genetics</i>. Genetics Society of America. <a href=\"https://doi.org/10.1534/genetics.115.180299\">https://doi.org/10.1534/genetics.115.180299</a>","mla":"Uecker, Hildegard, and Joachim Hermisson. “The Role of Recombination in Evolutionary Rescue.” <i>Genetics</i>, vol. 202, no. 2, Genetics Society of America, 2016, pp. 721–32, doi:<a href=\"https://doi.org/10.1534/genetics.115.180299\">10.1534/genetics.115.180299</a>.","chicago":"Uecker, Hildegard, and Joachim Hermisson. “The Role of Recombination in Evolutionary Rescue.” <i>Genetics</i>. Genetics Society of America, 2016. <a href=\"https://doi.org/10.1534/genetics.115.180299\">https://doi.org/10.1534/genetics.115.180299</a>.","ista":"Uecker H, Hermisson J. 2016. The role of recombination in evolutionary rescue. Genetics. 202(2), 721–732.","ieee":"H. Uecker and J. Hermisson, “The role of recombination in evolutionary rescue,” <i>Genetics</i>, vol. 202, no. 2. Genetics Society of America, pp. 721–732, 2016.","short":"H. Uecker, J. Hermisson, Genetics 202 (2016) 721–732.","ama":"Uecker H, Hermisson J. The role of recombination in evolutionary rescue. <i>Genetics</i>. 2016;202(2):721-732. doi:<a href=\"https://doi.org/10.1534/genetics.115.180299\">10.1534/genetics.115.180299</a>"},"issue":"2","user_id":"3E5EF7F0-F248-11E8-B48F-1D18A9856A87","oa":1,"language":[{"iso":"eng"}],"volume":202,"date_created":"2018-12-11T11:50:54Z","day":"01","scopus_import":1,"author":[{"last_name":"Uecker","id":"2DB8F68A-F248-11E8-B48F-1D18A9856A87","full_name":"Uecker, Hildegard","orcid":"0000-0001-9435-2813","first_name":"Hildegard"},{"full_name":"Hermisson, Joachim","last_name":"Hermisson","first_name":"Joachim"}],"oa_version":"Preprint","title":"The role of recombination in evolutionary rescue","publication_status":"published","intvolume":"       202","abstract":[{"text":"How likely is it that a population escapes extinction through adaptive evolution? The answer to this question is of great relevance in conservation biology, where we aim at species’ rescue and the maintenance of biodiversity, and in agriculture and medicine, where we seek to hamper the emergence of pesticide or drug resistance. By reshuffling the genome, recombination has two antagonistic effects on the probability of evolutionary rescue: It generates and it breaks up favorable gene combinations. Which of the two effects prevails depends on the fitness effects of mutations and on the impact of stochasticity on the allele frequencies. In this article, we analyze a mathematical model for rescue after a sudden environmental change when adaptation is contingent on mutations at two loci. The analysis reveals a complex nonlinear dependence of population survival on recombination. We moreover find that, counterintuitively, a fast eradication of the wild type can promote rescue in the presence of recombination. The model also shows that two-step rescue is not unlikely to happen and can even be more likely than single-step rescue (where adaptation relies on a single mutation), depending on the circumstances.","lang":"eng"}],"publist_id":"6091","year":"2016","ec_funded":1,"date_published":"2016-02-01T00:00:00Z","acknowledgement":"This work was made possible by a “For Women in Science” fellowship (L’Oréal Österreich in cooperation with the Austrian Commission for the United Nations Educational, Scientific, and Cultural Organization and the Austrian Academy of Sciences with financial support from the Federal Ministry for Science and Research Austria) and European Research Council grant 250152 (to Nick Barton).","publication":"Genetics","status":"public","project":[{"grant_number":"250152","name":"Limits to selection in biology and in evolutionary computation","call_identifier":"FP7","_id":"25B07788-B435-11E9-9278-68D0E5697425"},{"name":"L'OREAL Fellowship","_id":"25B67606-B435-11E9-9278-68D0E5697425"}],"_id":"1241","date_updated":"2023-02-21T10:24:19Z","type":"journal_article","doi":"10.1534/genetics.115.180299","publisher":"Genetics Society of America","main_file_link":[{"url":"http://biorxiv.org/content/early/2015/07/06/022020.abstract","open_access":"1"}],"quality_controlled":"1","page":"721 - 732"},{"quality_controlled":"1","page":"1523 - 1580","ddc":["576"],"_id":"1699","date_updated":"2023-02-23T10:10:36Z","type":"journal_article","doi":"10.1007/s00285-014-0802-y","publisher":"Springer","date_published":"2015-06-01T00:00:00Z","acknowledgement":"This work was made possible with financial support by the Vienna Science and Technology Fund (WWTF), by the Deutsche Forschungsgemeinschaft (DFG), Research Unit 1078 Natural selection in structured populations, by the Austrian Science Fund (FWF) via funding for the Vienna Graduate School for Population Genetics, and by a “For Women in Science” fellowship (L’Oréal Österreich in cooperation with the Austrian Commission for UNESCO and the Austrian Academy of Sciences with financial support from the Federal Ministry for Science and Research Austria).","status":"public","publication":"Journal of Mathematical Biology","project":[{"name":"L'OREAL Fellowship","_id":"25B67606-B435-11E9-9278-68D0E5697425"}],"publist_id":"5442","year":"2015","file_date_updated":"2020-07-14T12:45:12Z","publication_status":"published","has_accepted_license":"1","intvolume":"        70","tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","short":"CC BY (4.0)"},"abstract":[{"lang":"eng","text":"By hybridization and backcrossing, alleles can surmount species boundaries and be incorporated into the genome of a related species. This introgression of genes is of particular evolutionary relevance if it involves the transfer of adaptations between populations. However, any beneficial allele will typically be associated with other alien alleles that are often deleterious and hamper the introgression process. In order to describe the introgression of an adaptive allele, we set up a stochastic model with an explicit genetic makeup of linked and unlinked deleterious alleles. Based on the theory of reducible multitype branching processes, we derive a recursive expression for the establishment probability of the beneficial allele after a single hybridization event. We furthermore study the probability that slightly deleterious alleles hitchhike to fixation. The key to the analysis is a split of the process into a stochastic phase in which the advantageous alleles establishes and a deterministic phase in which it sweeps to fixation. We thereafter apply the theory to a set of biologically relevant scenarios such as introgression in the presence of many unlinked or few closely linked deleterious alleles. A comparison to computer simulations shows that the approximations work well over a large parameter range."}],"volume":70,"date_created":"2018-12-11T11:53:32Z","scopus_import":1,"day":"01","author":[{"last_name":"Uecker","id":"2DB8F68A-F248-11E8-B48F-1D18A9856A87","full_name":"Uecker, Hildegard","orcid":"0000-0001-9435-2813","first_name":"Hildegard"},{"last_name":"Setter","full_name":"Setter, Derek","first_name":"Derek"},{"full_name":"Hermisson, Joachim","last_name":"Hermisson","first_name":"Joachim"}],"oa_version":"Published Version","title":"Adaptive gene introgression after secondary contact","citation":{"mla":"Uecker, Hildegard, et al. “Adaptive Gene Introgression after Secondary Contact.” <i>Journal of Mathematical Biology</i>, vol. 70, no. 7, Springer, 2015, pp. 1523–80, doi:<a href=\"https://doi.org/10.1007/s00285-014-0802-y\">10.1007/s00285-014-0802-y</a>.","apa":"Uecker, H., Setter, D., &#38; Hermisson, J. (2015). Adaptive gene introgression after secondary contact. <i>Journal of Mathematical Biology</i>. Springer. <a href=\"https://doi.org/10.1007/s00285-014-0802-y\">https://doi.org/10.1007/s00285-014-0802-y</a>","ista":"Uecker H, Setter D, Hermisson J. 2015. Adaptive gene introgression after secondary contact. Journal of Mathematical Biology. 70(7), 1523–1580.","chicago":"Uecker, Hildegard, Derek Setter, and Joachim Hermisson. “Adaptive Gene Introgression after Secondary Contact.” <i>Journal of Mathematical Biology</i>. Springer, 2015. <a href=\"https://doi.org/10.1007/s00285-014-0802-y\">https://doi.org/10.1007/s00285-014-0802-y</a>.","short":"H. Uecker, D. Setter, J. Hermisson, Journal of Mathematical Biology 70 (2015) 1523–1580.","ieee":"H. Uecker, D. Setter, and J. Hermisson, “Adaptive gene introgression after secondary contact,” <i>Journal of Mathematical Biology</i>, vol. 70, no. 7. Springer, pp. 1523–1580, 2015.","ama":"Uecker H, Setter D, Hermisson J. Adaptive gene introgression after secondary contact. <i>Journal of Mathematical Biology</i>. 2015;70(7):1523-1580. doi:<a href=\"https://doi.org/10.1007/s00285-014-0802-y\">10.1007/s00285-014-0802-y</a>"},"issue":"7","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","oa":1,"pubrep_id":"458","language":[{"iso":"eng"}],"department":[{"_id":"NiBa"}],"file":[{"relation":"main_file","checksum":"00e3a67bda05d4cc165b3a48b41ef9ad","file_name":"IST-2016-458-v1+1_s00285-014-0802-y.pdf","content_type":"application/pdf","access_level":"open_access","file_id":"5079","file_size":1321527,"date_created":"2018-12-12T10:14:27Z","date_updated":"2020-07-14T12:45:12Z","creator":"system"}],"month":"06"}]