---
_id: '14314'
abstract:
- lang: eng
text: The execution of cognitive functions requires coordinated circuit activity
across different brain areas that involves the associated firing of neuronal assemblies.
Here, we tested the circuit mechanism behind assembly interactions between the
hippocampus and the medial prefrontal cortex (mPFC) of adult rats by recording
neuronal populations during a rule-switching task. We identified functionally
coupled CA1-mPFC cells that synchronized their activity beyond that expected from
common spatial coding or oscillatory firing. When such cell pairs fired together,
the mPFC cell strongly phase locked to CA1 theta oscillations and maintained consistent
theta firing phases, independent of the theta timing of their CA1 counterpart.
These functionally connected CA1-mPFC cells formed interconnected assemblies.
While firing together with their CA1 assembly partners, mPFC cells fired along
specific theta sequences. Our results suggest that upregulated theta oscillatory
firing of mPFC cells can signal transient interactions with specific CA1 assemblies,
thus enabling distributed computations.
acknowledgement: We thank A. Cumpelik, H. Chiossi, and L. Bollman for comments on
an earlier version of this manuscript. This work was funded by EU-FP7 MC-ITN IN-SENS
(grant 607616).
article_number: '113015'
article_processing_charge: Yes
article_type: original
author:
- first_name: Michele
full_name: Nardin, Michele
id: 30BD0376-F248-11E8-B48F-1D18A9856A87
last_name: Nardin
orcid: 0000-0001-8849-6570
- first_name: Karola
full_name: Käfer, Karola
id: 2DAA49AA-F248-11E8-B48F-1D18A9856A87
last_name: Käfer
- first_name: Federico
full_name: Stella, Federico
id: 39AF1E74-F248-11E8-B48F-1D18A9856A87
last_name: Stella
orcid: 0000-0001-9439-3148
- first_name: Jozsef L
full_name: Csicsvari, Jozsef L
id: 3FA14672-F248-11E8-B48F-1D18A9856A87
last_name: Csicsvari
orcid: 0000-0002-5193-4036
citation:
ama: Nardin M, Käfer K, Stella F, Csicsvari JL. Theta oscillations as a substrate
for medial prefrontal-hippocampal assembly interactions. Cell Reports.
2023;42(9). doi:10.1016/j.celrep.2023.113015
apa: Nardin, M., Käfer, K., Stella, F., & Csicsvari, J. L. (2023). Theta oscillations
as a substrate for medial prefrontal-hippocampal assembly interactions. Cell
Reports. Elsevier. https://doi.org/10.1016/j.celrep.2023.113015
chicago: Nardin, Michele, Karola Käfer, Federico Stella, and Jozsef L Csicsvari.
“Theta Oscillations as a Substrate for Medial Prefrontal-Hippocampal Assembly
Interactions.” Cell Reports. Elsevier, 2023. https://doi.org/10.1016/j.celrep.2023.113015.
ieee: M. Nardin, K. Käfer, F. Stella, and J. L. Csicsvari, “Theta oscillations as
a substrate for medial prefrontal-hippocampal assembly interactions,” Cell
Reports, vol. 42, no. 9. Elsevier, 2023.
ista: Nardin M, Käfer K, Stella F, Csicsvari JL. 2023. Theta oscillations as a substrate
for medial prefrontal-hippocampal assembly interactions. Cell Reports. 42(9),
113015.
mla: Nardin, Michele, et al. “Theta Oscillations as a Substrate for Medial Prefrontal-Hippocampal
Assembly Interactions.” Cell Reports, vol. 42, no. 9, 113015, Elsevier,
2023, doi:10.1016/j.celrep.2023.113015.
short: M. Nardin, K. Käfer, F. Stella, J.L. Csicsvari, Cell Reports 42 (2023).
date_created: 2023-09-10T22:01:11Z
date_published: 2023-09-26T00:00:00Z
date_updated: 2023-09-15T07:14:12Z
day: '26'
ddc:
- '570'
department:
- _id: JoCs
doi: 10.1016/j.celrep.2023.113015
ec_funded: 1
external_id:
pmid:
- '37632747'
file:
- access_level: open_access
checksum: ca77a304fb813c292550b8604b0fb41d
content_type: application/pdf
creator: dernst
date_created: 2023-09-15T07:12:46Z
date_updated: 2023-09-15T07:12:46Z
file_id: '14337'
file_name: 2023_CellPress_Nardin.pdf
file_size: 4879455
relation: main_file
success: 1
file_date_updated: 2023-09-15T07:12:46Z
has_accepted_license: '1'
intvolume: ' 42'
issue: '9'
language:
- iso: eng
license: https://creativecommons.org/licenses/by/4.0/
month: '09'
oa: 1
oa_version: Published Version
pmid: 1
project:
- _id: 257BBB4C-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '607616'
name: Inter-and intracellular signalling in schizophrenia
publication: Cell Reports
publication_identifier:
eissn:
- 2211-1247
publication_status: published
publisher: Elsevier
quality_controlled: '1'
scopus_import: '1'
status: public
title: Theta oscillations as a substrate for medial prefrontal-hippocampal assembly
interactions
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 42
year: '2023'
...
---
_id: '10080'
abstract:
- lang: eng
text: Hippocampal and neocortical neural activity is modulated by the position of
the individual in space. While hippocampal neurons provide the basis for a spatial
map, prefrontal cortical neurons generalize over environmental features. Whether
these generalized representations result from a bidirectional interaction with,
or are mainly derived from hippocampal spatial representations is not known. By
examining simultaneously recorded hippocampal and medial prefrontal neurons, we
observed that prefrontal spatial representations show a delayed coherence with
hippocampal ones. We also identified subpopulations of cells in the hippocampus
and medial prefrontal cortex that formed functional cross-area couplings; these
resembled the optimal connections predicted by a probabilistic model of spatial
information transfer and generalization. Moreover, cross-area couplings were strongest
and had the shortest delay preceding spatial decision-making. Our results suggest
that generalized spatial coding in the medial prefrontal cortex is inherited from
spatial representations in the hippocampus, and that the routing of information
can change dynamically with behavioral demands.
acknowledgement: We thank Federico Stella for invaluable suggestions and discussions.
We thank Yosman BapatDhar and Andrea Cumpelik for comments, help and suggestions
on the exposure of the text. We thank Predrag Živadinović and Juliana Couras for
comments on the text and the figures. This work was supported by the EU-FP7 MC-ITN
IN-SENS (grant 607616).
article_processing_charge: No
author:
- first_name: Michele
full_name: Nardin, Michele
id: 30BD0376-F248-11E8-B48F-1D18A9856A87
last_name: Nardin
orcid: 0000-0001-8849-6570
- first_name: Karola
full_name: Käfer, Karola
id: 2DAA49AA-F248-11E8-B48F-1D18A9856A87
last_name: Käfer
- first_name: Jozsef L
full_name: Csicsvari, Jozsef L
id: 3FA14672-F248-11E8-B48F-1D18A9856A87
last_name: Csicsvari
orcid: 0000-0002-5193-4036
citation:
ama: Nardin M, Käfer K, Csicsvari JL. The generalized spatial representation in
the prefrontal cortex is inherited from the hippocampus. bioRxiv. doi:10.1101/2021.09.30.462269
apa: Nardin, M., Käfer, K., & Csicsvari, J. L. (n.d.). The generalized spatial
representation in the prefrontal cortex is inherited from the hippocampus. bioRxiv.
Cold Spring Harbor Laboratory. https://doi.org/10.1101/2021.09.30.462269
chicago: Nardin, Michele, Karola Käfer, and Jozsef L Csicsvari. “The Generalized
Spatial Representation in the Prefrontal Cortex Is Inherited from the Hippocampus.”
BioRxiv. Cold Spring Harbor Laboratory, n.d. https://doi.org/10.1101/2021.09.30.462269.
ieee: M. Nardin, K. Käfer, and J. L. Csicsvari, “The generalized spatial representation
in the prefrontal cortex is inherited from the hippocampus,” bioRxiv. Cold
Spring Harbor Laboratory.
ista: Nardin M, Käfer K, Csicsvari JL. The generalized spatial representation in
the prefrontal cortex is inherited from the hippocampus. bioRxiv, 10.1101/2021.09.30.462269.
mla: Nardin, Michele, et al. “The Generalized Spatial Representation in the Prefrontal
Cortex Is Inherited from the Hippocampus.” BioRxiv, Cold Spring Harbor
Laboratory, doi:10.1101/2021.09.30.462269.
short: M. Nardin, K. Käfer, J.L. Csicsvari, BioRxiv (n.d.).
date_created: 2021-10-04T06:28:32Z
date_published: 2021-10-02T00:00:00Z
date_updated: 2021-10-05T12:34:26Z
day: '02'
department:
- _id: GradSch
- _id: JoCs
doi: 10.1101/2021.09.30.462269
ec_funded: 1
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.biorxiv.org/content/10.1101/2021.09.30.462269
month: '10'
oa: 1
oa_version: Preprint
project:
- _id: 257BBB4C-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '607616'
name: Inter-and intracellular signalling in schizophrenia
publication: bioRxiv
publication_status: submitted
publisher: Cold Spring Harbor Laboratory
status: public
title: The generalized spatial representation in the prefrontal cortex is inherited
from the hippocampus
type: preprint
user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
year: '2021'
...
---
_id: '7472'
abstract:
- lang: eng
text: Temporally organized reactivation of experiences during awake immobility periods
is thought to underlie cognitive processes like planning and evaluation. While
replay of trajectories is well established for the hippocampus, it is unclear
whether the medial prefrontal cortex (mPFC) can reactivate sequential behavioral
experiences in the awake state to support task execution. We simultaneously recorded
from hippocampal and mPFC principal neurons in rats performing a mPFC-dependent
rule-switching task on a plus maze. We found that mPFC neuronal activity encoded
relative positions between the start and goal. During awake immobility periods,
the mPFC replayed temporally organized sequences of these generalized positions,
resembling entire spatial trajectories. The occurrence of mPFC trajectory replay
positively correlated with rule-switching performance. However, hippocampal and
mPFC trajectory replay occurred independently, indicating different functions.
These results demonstrate that the mPFC can replay ordered activity patterns representing
generalized locations and suggest that mPFC replay might have a role in flexible
behavior.
acknowledged_ssus:
- _id: M-Shop
acknowledgement: We thank Todor Asenov and Thomas Menner from the Machine Shop for
the drive design and production, Hugo Malagon-Vina for assistance in maze automatization,
Jago Wallenschus for taking the images of the histology, and Federico Stella and
Juan Felipe Ramirez-Villegas for comments on an earlier version of the manuscript.
This work was supported by the EU-FP7 MC-ITN IN-SENS (grant 607616 ).
article_processing_charge: No
article_type: original
author:
- first_name: Karola
full_name: Käfer, Karola
id: 2DAA49AA-F248-11E8-B48F-1D18A9856A87
last_name: Käfer
- first_name: Michele
full_name: Nardin, Michele
id: 30BD0376-F248-11E8-B48F-1D18A9856A87
last_name: Nardin
orcid: 0000-0001-8849-6570
- first_name: Karel
full_name: Blahna, Karel
id: 3EA859AE-F248-11E8-B48F-1D18A9856A87
last_name: Blahna
- first_name: Jozsef L
full_name: Csicsvari, Jozsef L
id: 3FA14672-F248-11E8-B48F-1D18A9856A87
last_name: Csicsvari
orcid: 0000-0002-5193-4036
citation:
ama: Käfer K, Nardin M, Blahna K, Csicsvari JL. Replay of behavioral sequences in
the medial prefrontal cortex during rule switching. Neuron. 2020;106(1):P154-165.e6.
doi:10.1016/j.neuron.2020.01.015
apa: Käfer, K., Nardin, M., Blahna, K., & Csicsvari, J. L. (2020). Replay of
behavioral sequences in the medial prefrontal cortex during rule switching. Neuron.
Elsevier. https://doi.org/10.1016/j.neuron.2020.01.015
chicago: Käfer, Karola, Michele Nardin, Karel Blahna, and Jozsef L Csicsvari. “Replay
of Behavioral Sequences in the Medial Prefrontal Cortex during Rule Switching.”
Neuron. Elsevier, 2020. https://doi.org/10.1016/j.neuron.2020.01.015.
ieee: K. Käfer, M. Nardin, K. Blahna, and J. L. Csicsvari, “Replay of behavioral
sequences in the medial prefrontal cortex during rule switching,” Neuron,
vol. 106, no. 1. Elsevier, p. P154–165.e6, 2020.
ista: Käfer K, Nardin M, Blahna K, Csicsvari JL. 2020. Replay of behavioral sequences
in the medial prefrontal cortex during rule switching. Neuron. 106(1), P154–165.e6.
mla: Käfer, Karola, et al. “Replay of Behavioral Sequences in the Medial Prefrontal
Cortex during Rule Switching.” Neuron, vol. 106, no. 1, Elsevier, 2020,
p. P154–165.e6, doi:10.1016/j.neuron.2020.01.015.
short: K. Käfer, M. Nardin, K. Blahna, J.L. Csicsvari, Neuron 106 (2020) P154–165.e6.
date_created: 2020-02-10T15:45:48Z
date_published: 2020-04-08T00:00:00Z
date_updated: 2023-08-17T14:38:02Z
day: '08'
department:
- _id: JoCs
doi: 10.1016/j.neuron.2020.01.015
ec_funded: 1
external_id:
isi:
- '000525319300016'
pmid:
- '32032512'
intvolume: ' 106'
isi: 1
issue: '1'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1016/j.neuron.2020.01.015
month: '04'
oa: 1
oa_version: Published Version
page: P154-165.e6
pmid: 1
project:
- _id: 257BBB4C-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '607616'
name: Inter-and intracellular signalling in schizophrenia
publication: Neuron
publication_identifier:
issn:
- 0896-6273
publication_status: published
publisher: Elsevier
quality_controlled: '1'
related_material:
link:
- description: News on IST Homepage
relation: press_release
url: https://ist.ac.at/en/news/this-brain-area-helps-us-decide/
scopus_import: '1'
status: public
title: Replay of behavioral sequences in the medial prefrontal cortex during rule
switching
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 106
year: '2020'
...
---
_id: '5949'
abstract:
- lang: eng
text: Aberrant proteostasis of protein aggregation may lead to behavior disorders
including chronic mental illnesses (CMI). Furthermore, the neuronal activity alterations
that underlie CMI are not well understood. We recorded the local field potential
and single-unit activity of the hippocampal CA1 region in vivo in rats transgenically
overexpressing the Disrupted-in-Schizophrenia 1 (DISC1) gene (tgDISC1), modeling
sporadic CMI. These tgDISC1 rats have previously been shown to exhibit DISC1 protein
aggregation, disturbances in the dopaminergic system and attention-related deficits.
Recordings were performed during exploration of familiar and novel open field
environments and during sleep, allowing investigation of neuronal abnormalities
in unconstrained behavior. Compared to controls, tgDISC1 place cells exhibited
smaller place fields and decreased speed-modulation of their firing rates, demonstrating
altered spatial coding and deficits in encoding location-independent sensory inputs.
Oscillation analyses showed that tgDISC1 pyramidal neurons had higher theta phase
locking strength during novelty, limiting their phase coding ability. However,
their mean theta phases were more variable at the population level, reducing oscillatory
network synchronization. Finally, tgDISC1 pyramidal neurons showed a lack of novelty-induced
shift in their preferred theta and gamma firing phases, indicating deficits in
coding of novel environments with oscillatory firing. By combining single cell
and neuronal population analyses, we link DISC1 protein pathology with abnormal
hippocampal neural coding and network synchrony, and thereby gain a more comprehensive
understanding of CMI mechanisms.
article_processing_charge: Yes (via OA deal)
article_type: original
author:
- first_name: Karola
full_name: Käfer, Karola
id: 2DAA49AA-F248-11E8-B48F-1D18A9856A87
last_name: Käfer
- first_name: Hugo
full_name: Malagon-Vina, Hugo
last_name: Malagon-Vina
- first_name: Desiree
full_name: Dickerson, Desiree
id: 444EB89E-F248-11E8-B48F-1D18A9856A87
last_name: Dickerson
- first_name: Joseph
full_name: O'Neill, Joseph
last_name: O'Neill
- first_name: Svenja V.
full_name: Trossbach, Svenja V.
last_name: Trossbach
- first_name: Carsten
full_name: Korth, Carsten
last_name: Korth
- first_name: Jozsef L
full_name: Csicsvari, Jozsef L
id: 3FA14672-F248-11E8-B48F-1D18A9856A87
last_name: Csicsvari
orcid: 0000-0002-5193-4036
citation:
ama: Käfer K, Malagon-Vina H, Dickerson D, et al. Disrupted-in-schizophrenia 1 overexpression
disrupts hippocampal coding and oscillatory synchronization. Hippocampus.
2019;29(9):802-816. doi:10.1002/hipo.23076
apa: Käfer, K., Malagon-Vina, H., Dickerson, D., O’Neill, J., Trossbach, S. V.,
Korth, C., & Csicsvari, J. L. (2019). Disrupted-in-schizophrenia 1 overexpression
disrupts hippocampal coding and oscillatory synchronization. Hippocampus.
Wiley. https://doi.org/10.1002/hipo.23076
chicago: Käfer, Karola, Hugo Malagon-Vina, Desiree Dickerson, Joseph O’Neill, Svenja
V. Trossbach, Carsten Korth, and Jozsef L Csicsvari. “Disrupted-in-Schizophrenia
1 Overexpression Disrupts Hippocampal Coding and Oscillatory Synchronization.”
Hippocampus. Wiley, 2019. https://doi.org/10.1002/hipo.23076.
ieee: K. Käfer et al., “Disrupted-in-schizophrenia 1 overexpression disrupts
hippocampal coding and oscillatory synchronization,” Hippocampus, vol.
29, no. 9. Wiley, pp. 802–816, 2019.
ista: Käfer K, Malagon-Vina H, Dickerson D, O’Neill J, Trossbach SV, Korth C, Csicsvari
JL. 2019. Disrupted-in-schizophrenia 1 overexpression disrupts hippocampal coding
and oscillatory synchronization. Hippocampus. 29(9), 802–816.
mla: Käfer, Karola, et al. “Disrupted-in-Schizophrenia 1 Overexpression Disrupts
Hippocampal Coding and Oscillatory Synchronization.” Hippocampus, vol.
29, no. 9, Wiley, 2019, pp. 802–16, doi:10.1002/hipo.23076.
short: K. Käfer, H. Malagon-Vina, D. Dickerson, J. O’Neill, S.V. Trossbach, C. Korth,
J.L. Csicsvari, Hippocampus 29 (2019) 802–816.
date_created: 2019-02-10T22:59:18Z
date_published: 2019-09-01T00:00:00Z
date_updated: 2024-03-25T23:30:11Z
day: '01'
ddc:
- '570'
department:
- _id: JoCs
doi: 10.1002/hipo.23076
ec_funded: 1
external_id:
isi:
- '000480635400003'
file:
- access_level: open_access
checksum: 5e8de271ca04aef92a5de42d6aac4404
content_type: application/pdf
creator: dernst
date_created: 2019-02-11T10:42:51Z
date_updated: 2020-07-14T12:47:13Z
file_id: '5950'
file_name: 2019_Hippocampus_Kaefer.pdf
file_size: 2132893
relation: main_file
file_date_updated: 2020-07-14T12:47:13Z
has_accepted_license: '1'
intvolume: ' 29'
isi: 1
issue: '9'
language:
- iso: eng
month: '09'
oa: 1
oa_version: Published Version
page: 802-816
project:
- _id: 257BBB4C-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '607616'
name: Inter-and intracellular signalling in schizophrenia
publication: Hippocampus
publication_status: published
publisher: Wiley
quality_controlled: '1'
related_material:
record:
- id: '6825'
relation: dissertation_contains
status: public
scopus_import: '1'
status: public
title: Disrupted-in-schizophrenia 1 overexpression disrupts hippocampal coding and
oscillatory synchronization
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 29
year: '2019'
...