---
_id: '2827'
abstract:
- lang: eng
  text: Removal of cargos from the cell surface via endocytosis is an efficient mechanism
    to regulate activities of plasma membrane (PM)-resident proteins, such as receptors
    or transporters. Salicylic acid (SA) is an important plant hormone that is traditionally
    associated with pathogen defense. Here, we describe an unanticipated effect of
    SA on subcellular endocytic cycling of proteins. Both exogenous treatments and
    endogenously enhanced SA levels repressed endocytosis of different PM proteins.
    The SA effect on endocytosis did not involve transcription or known components
    of the SA signaling pathway for transcriptional regulation. SA likely targets
    an endocytic mechanism that involves the coat protein clathrin, because SA interfered
    with the clathrin incidence at the PM and clathrin-deficient mutants were less
    sensitive to the impact of SA on the auxin distribution and root bending during
    the gravitropic response. By contrast, SA did not affect the ligand-induced endocytosis
    of the FLAGELLIN SENSING2 (FLS2) receptor during pathogen responses. Our data
    suggest that the established SA impact on transcription in plant immunity and
    the nontranscriptional effect of SA on clathrin-mediated endocytosis are independent
    mechanisms by which SA regulates distinct aspects of plant physiology.
author:
- first_name: Yunlong
  full_name: Du, Yunlong
  last_name: Du
- first_name: Ricardo
  full_name: Tejos, Ricardo
  last_name: Tejos
- first_name: Martina
  full_name: Beck, Martina
  last_name: Beck
- first_name: Ellie
  full_name: Himschoot, Ellie
  last_name: Himschoot
- first_name: Hongjiang
  full_name: Li, Hongjiang
  id: 33CA54A6-F248-11E8-B48F-1D18A9856A87
  last_name: Li
  orcid: 0000-0001-5039-9660
- first_name: Silke
  full_name: Robatzek, Silke
  last_name: Robatzek
- first_name: Steffen
  full_name: Vanneste, Steffen
  last_name: Vanneste
- first_name: Jirí
  full_name: Friml, Jirí
  id: 4159519E-F248-11E8-B48F-1D18A9856A87
  last_name: Friml
  orcid: 0000-0002-8302-7596
citation:
  ama: Du Y, Tejos R, Beck M, et al. Salicylic acid interferes with clathrin-mediated
    endocytic protein trafficking. <i>PNAS</i>. 2013;110(19):7946-7951. doi:<a href="https://doi.org/10.1073/pnas.1220205110">10.1073/pnas.1220205110</a>
  apa: Du, Y., Tejos, R., Beck, M., Himschoot, E., Li, H., Robatzek, S., … Friml,
    J. (2013). Salicylic acid interferes with clathrin-mediated endocytic protein
    trafficking. <i>PNAS</i>. National Academy of Sciences. <a href="https://doi.org/10.1073/pnas.1220205110">https://doi.org/10.1073/pnas.1220205110</a>
  chicago: Du, Yunlong, Ricardo Tejos, Martina Beck, Ellie Himschoot, Hongjiang Li,
    Silke Robatzek, Steffen Vanneste, and Jiří Friml. “Salicylic Acid Interferes with
    Clathrin-Mediated Endocytic Protein Trafficking.” <i>PNAS</i>. National Academy
    of Sciences, 2013. <a href="https://doi.org/10.1073/pnas.1220205110">https://doi.org/10.1073/pnas.1220205110</a>.
  ieee: Y. Du <i>et al.</i>, “Salicylic acid interferes with clathrin-mediated endocytic
    protein trafficking,” <i>PNAS</i>, vol. 110, no. 19. National Academy of Sciences,
    pp. 7946–7951, 2013.
  ista: Du Y, Tejos R, Beck M, Himschoot E, Li H, Robatzek S, Vanneste S, Friml J.
    2013. Salicylic acid interferes with clathrin-mediated endocytic protein trafficking.
    PNAS. 110(19), 7946–7951.
  mla: Du, Yunlong, et al. “Salicylic Acid Interferes with Clathrin-Mediated Endocytic
    Protein Trafficking.” <i>PNAS</i>, vol. 110, no. 19, National Academy of Sciences,
    2013, pp. 7946–51, doi:<a href="https://doi.org/10.1073/pnas.1220205110">10.1073/pnas.1220205110</a>.
  short: Y. Du, R. Tejos, M. Beck, E. Himschoot, H. Li, S. Robatzek, S. Vanneste,
    J. Friml, PNAS 110 (2013) 7946–7951.
date_created: 2018-12-11T11:59:48Z
date_published: 2013-05-07T00:00:00Z
date_updated: 2021-01-12T06:59:59Z
day: '07'
department:
- _id: JiFr
doi: 10.1073/pnas.1220205110
external_id:
  pmid:
  - '23613581'
intvolume: '       110'
issue: '19'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3651428/
month: '05'
oa: 1
oa_version: Submitted Version
page: 7946 - 7951
pmid: 1
project:
- _id: 2574781E-B435-11E9-9278-68D0E5697425
  name: Koerber Prize 2010
publication: PNAS
publication_status: published
publisher: National Academy of Sciences
publist_id: '3972'
quality_controlled: '1'
scopus_import: 1
status: public
title: Salicylic acid interferes with clathrin-mediated endocytic protein trafficking
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 110
year: '2013'
...