---
_id: '735'
abstract:
- lang: eng
  text: Cell-cell contact formation constitutes an essential step in evolution, leading
    to the differentiation of specialized cell types. However, remarkably little is
    known about whether and how the interplay between contact formation and fate specification
    affects development. Here, we identify a positive feedback loop between cell-cell
    contact duration, morphogen signaling, and mesendoderm cell-fate specification
    during zebrafish gastrulation. We show that long-lasting cell-cell contacts enhance
    the competence of prechordal plate (ppl) progenitor cells to respond to Nodal
    signaling, required for ppl cell-fate specification. We further show that Nodal
    signaling promotes ppl cell-cell contact duration, generating a positive feedback
    loop between ppl cell-cell contact duration and cell-fate specification. Finally,
    by combining mathematical modeling and experimentation, we show that this feedback
    determines whether anterior axial mesendoderm cells become ppl or, instead, turn
    into endoderm. Thus, the interdependent activities of cell-cell signaling and
    contact formation control fate diversification within the developing embryo.
article_processing_charge: No
author:
- first_name: Vanessa
  full_name: Barone, Vanessa
  id: 419EECCC-F248-11E8-B48F-1D18A9856A87
  last_name: Barone
  orcid: 0000-0003-2676-3367
- first_name: Moritz
  full_name: Lang, Moritz
  id: 29E0800A-F248-11E8-B48F-1D18A9856A87
  last_name: Lang
- first_name: Gabriel
  full_name: Krens, Gabriel
  id: 2B819732-F248-11E8-B48F-1D18A9856A87
  last_name: Krens
  orcid: 0000-0003-4761-5996
- first_name: Saurabh
  full_name: Pradhan, Saurabh
  last_name: Pradhan
- first_name: Shayan
  full_name: Shamipour, Shayan
  id: 40B34FE2-F248-11E8-B48F-1D18A9856A87
  last_name: Shamipour
- first_name: Keisuke
  full_name: Sako, Keisuke
  id: 3BED66BE-F248-11E8-B48F-1D18A9856A87
  last_name: Sako
  orcid: 0000-0002-6453-8075
- first_name: Mateusz K
  full_name: Sikora, Mateusz K
  id: 2F74BCDE-F248-11E8-B48F-1D18A9856A87
  last_name: Sikora
- first_name: Calin C
  full_name: Guet, Calin C
  id: 47F8433E-F248-11E8-B48F-1D18A9856A87
  last_name: Guet
  orcid: 0000-0001-6220-2052
- first_name: Carl-Philipp J
  full_name: Heisenberg, Carl-Philipp J
  id: 39427864-F248-11E8-B48F-1D18A9856A87
  last_name: Heisenberg
  orcid: 0000-0002-0912-4566
citation:
  ama: Barone V, Lang M, Krens G, et al. An effective feedback loop between cell-cell
    contact duration and morphogen signaling determines cell fate. <i>Developmental
    Cell</i>. 2017;43(2):198-211. doi:<a href="https://doi.org/10.1016/j.devcel.2017.09.014">10.1016/j.devcel.2017.09.014</a>
  apa: Barone, V., Lang, M., Krens, G., Pradhan, S., Shamipour, S., Sako, K., … Heisenberg,
    C.-P. J. (2017). An effective feedback loop between cell-cell contact duration
    and morphogen signaling determines cell fate. <i>Developmental Cell</i>. Cell
    Press. <a href="https://doi.org/10.1016/j.devcel.2017.09.014">https://doi.org/10.1016/j.devcel.2017.09.014</a>
  chicago: Barone, Vanessa, Moritz Lang, Gabriel Krens, Saurabh Pradhan, Shayan Shamipour,
    Keisuke Sako, Mateusz K Sikora, Calin C Guet, and Carl-Philipp J Heisenberg. “An
    Effective Feedback Loop between Cell-Cell Contact Duration and Morphogen Signaling
    Determines Cell Fate.” <i>Developmental Cell</i>. Cell Press, 2017. <a href="https://doi.org/10.1016/j.devcel.2017.09.014">https://doi.org/10.1016/j.devcel.2017.09.014</a>.
  ieee: V. Barone <i>et al.</i>, “An effective feedback loop between cell-cell contact
    duration and morphogen signaling determines cell fate,” <i>Developmental Cell</i>,
    vol. 43, no. 2. Cell Press, pp. 198–211, 2017.
  ista: Barone V, Lang M, Krens G, Pradhan S, Shamipour S, Sako K, Sikora MK, Guet
    CC, Heisenberg C-PJ. 2017. An effective feedback loop between cell-cell contact
    duration and morphogen signaling determines cell fate. Developmental Cell. 43(2),
    198–211.
  mla: Barone, Vanessa, et al. “An Effective Feedback Loop between Cell-Cell Contact
    Duration and Morphogen Signaling Determines Cell Fate.” <i>Developmental Cell</i>,
    vol. 43, no. 2, Cell Press, 2017, pp. 198–211, doi:<a href="https://doi.org/10.1016/j.devcel.2017.09.014">10.1016/j.devcel.2017.09.014</a>.
  short: V. Barone, M. Lang, G. Krens, S. Pradhan, S. Shamipour, K. Sako, M.K. Sikora,
    C.C. Guet, C.-P.J. Heisenberg, Developmental Cell 43 (2017) 198–211.
date_created: 2018-12-11T11:48:13Z
date_published: 2017-10-23T00:00:00Z
date_updated: 2024-03-25T23:30:21Z
day: '23'
department:
- _id: CaHe
- _id: CaGu
- _id: GaTk
doi: 10.1016/j.devcel.2017.09.014
ec_funded: 1
external_id:
  isi:
  - '000413443700011'
intvolume: '        43'
isi: 1
issue: '2'
language:
- iso: eng
month: '10'
oa_version: None
page: 198 - 211
project:
- _id: 25681D80-B435-11E9-9278-68D0E5697425
  call_identifier: FP7
  grant_number: '291734'
  name: International IST Postdoc Fellowship Programme
- _id: 252DD2A6-B435-11E9-9278-68D0E5697425
  call_identifier: FWF
  grant_number: I2058
  name: 'Cell segregation in gastrulation: the role of cell fate specification'
publication: Developmental Cell
publication_identifier:
  issn:
  - '15345807'
publication_status: published
publisher: Cell Press
publist_id: '6934'
quality_controlled: '1'
related_material:
  record:
  - id: '961'
    relation: dissertation_contains
    status: public
  - id: '8350'
    relation: dissertation_contains
    status: public
scopus_import: '1'
status: public
title: An effective feedback loop between cell-cell contact duration and morphogen
  signaling determines cell fate
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 43
year: '2017'
...