---
_id: '1100'
abstract:
- lang: eng
  text: During metazoan development, the temporal pattern of morphogen signaling is
    critical for organizing cell fates in space and time. Yet, tools for temporally
    controlling morphogen signaling within the embryo are still scarce. Here, we developed
    a photoactivatable Nodal receptor to determine how the temporal pattern of Nodal
    signaling affects cell fate specification during zebrafish gastrulation. By using
    this receptor to manipulate the duration of Nodal signaling in vivo by light,
    we show that extended Nodal signaling within the organizer promotes prechordal
    plate specification and suppresses endoderm differentiation. Endoderm differentiation
    is suppressed by extended Nodal signaling inducing expression of the transcriptional
    repressor goosecoid (gsc) in prechordal plate progenitors, which in turn restrains
    Nodal signaling from upregulating the endoderm differentiation gene sox17 within
    these cells. Thus, optogenetic manipulation of Nodal signaling identifies a critical
    role of Nodal signaling duration for organizer cell fate specification during
    gastrulation.
acknowledged_ssus:
- _id: SSU
acknowledgement: 'We are grateful to members of the C.-P.H. and H.J. labs for discussions,
  R. Hauschild and the different Scientific Service Units at IST Austria for technical
  help, M. Dravecka for performing initial experiments, A. Schier for reading an earlier
  version of the manuscript, K.W. Rogers for technical help, and C. Hill, A. Bruce,
  and L. Solnica-Krezel for sending plasmids. This work was supported by grants from
  the Austrian Science Foundation (FWF): (T560-B17) and (I 812-B12) to V.R. and C.-P.H.,
  and from the European Union (EU FP7): (6275) to H.J. A.I.-P. is supported by a Ramon
  Areces fellowship.'
author:
- first_name: Keisuke
  full_name: Sako, Keisuke
  id: 3BED66BE-F248-11E8-B48F-1D18A9856A87
  last_name: Sako
  orcid: 0000-0002-6453-8075
- first_name: Saurabh
  full_name: Pradhan, Saurabh
  last_name: Pradhan
- first_name: Vanessa
  full_name: Barone, Vanessa
  id: 419EECCC-F248-11E8-B48F-1D18A9856A87
  last_name: Barone
  orcid: 0000-0003-2676-3367
- first_name: Álvaro
  full_name: Inglés Prieto, Álvaro
  id: 2A9DB292-F248-11E8-B48F-1D18A9856A87
  last_name: Inglés Prieto
  orcid: 0000-0002-5409-8571
- first_name: Patrick
  full_name: Mueller, Patrick
  last_name: Mueller
- first_name: Verena
  full_name: Ruprecht, Verena
  id: 4D71A03A-F248-11E8-B48F-1D18A9856A87
  last_name: Ruprecht
  orcid: 0000-0003-4088-8633
- first_name: Daniel
  full_name: Capek, Daniel
  id: 31C42484-F248-11E8-B48F-1D18A9856A87
  last_name: Capek
  orcid: 0000-0001-5199-9940
- first_name: Sanjeev
  full_name: Galande, Sanjeev
  last_name: Galande
- first_name: Harald L
  full_name: Janovjak, Harald L
  id: 33BA6C30-F248-11E8-B48F-1D18A9856A87
  last_name: Janovjak
  orcid: 0000-0002-8023-9315
- first_name: Carl-Philipp J
  full_name: Heisenberg, Carl-Philipp J
  id: 39427864-F248-11E8-B48F-1D18A9856A87
  last_name: Heisenberg
  orcid: 0000-0002-0912-4566
citation:
  ama: Sako K, Pradhan S, Barone V, et al. Optogenetic control of nodal signaling
    reveals a temporal pattern of nodal signaling regulating cell fate specification
    during gastrulation. <i>Cell Reports</i>. 2016;16(3):866-877. doi:<a href="https://doi.org/10.1016/j.celrep.2016.06.036">10.1016/j.celrep.2016.06.036</a>
  apa: Sako, K., Pradhan, S., Barone, V., Inglés Prieto, Á., Mueller, P., Ruprecht,
    V., … Heisenberg, C.-P. J. (2016). Optogenetic control of nodal signaling reveals
    a temporal pattern of nodal signaling regulating cell fate specification during
    gastrulation. <i>Cell Reports</i>. Cell Press. <a href="https://doi.org/10.1016/j.celrep.2016.06.036">https://doi.org/10.1016/j.celrep.2016.06.036</a>
  chicago: Sako, Keisuke, Saurabh Pradhan, Vanessa Barone, Álvaro Inglés Prieto, Patrick
    Mueller, Verena Ruprecht, Daniel Capek, Sanjeev Galande, Harald L Janovjak, and
    Carl-Philipp J Heisenberg. “Optogenetic Control of Nodal Signaling Reveals a Temporal
    Pattern of Nodal Signaling Regulating Cell Fate Specification during Gastrulation.”
    <i>Cell Reports</i>. Cell Press, 2016. <a href="https://doi.org/10.1016/j.celrep.2016.06.036">https://doi.org/10.1016/j.celrep.2016.06.036</a>.
  ieee: K. Sako <i>et al.</i>, “Optogenetic control of nodal signaling reveals a temporal
    pattern of nodal signaling regulating cell fate specification during gastrulation,”
    <i>Cell Reports</i>, vol. 16, no. 3. Cell Press, pp. 866–877, 2016.
  ista: Sako K, Pradhan S, Barone V, Inglés Prieto Á, Mueller P, Ruprecht V, Capek
    D, Galande S, Janovjak HL, Heisenberg C-PJ. 2016. Optogenetic control of nodal
    signaling reveals a temporal pattern of nodal signaling regulating cell fate specification
    during gastrulation. Cell Reports. 16(3), 866–877.
  mla: Sako, Keisuke, et al. “Optogenetic Control of Nodal Signaling Reveals a Temporal
    Pattern of Nodal Signaling Regulating Cell Fate Specification during Gastrulation.”
    <i>Cell Reports</i>, vol. 16, no. 3, Cell Press, 2016, pp. 866–77, doi:<a href="https://doi.org/10.1016/j.celrep.2016.06.036">10.1016/j.celrep.2016.06.036</a>.
  short: K. Sako, S. Pradhan, V. Barone, Á. Inglés Prieto, P. Mueller, V. Ruprecht,
    D. Capek, S. Galande, H.L. Janovjak, C.-P.J. Heisenberg, Cell Reports 16 (2016)
    866–877.
date_created: 2018-12-11T11:50:08Z
date_published: 2016-07-19T00:00:00Z
date_updated: 2024-03-25T23:30:13Z
day: '19'
ddc:
- '570'
- '576'
department:
- _id: CaHe
- _id: HaJa
doi: 10.1016/j.celrep.2016.06.036
ec_funded: 1
file:
- access_level: open_access
  content_type: application/pdf
  creator: system
  date_created: 2018-12-12T10:11:04Z
  date_updated: 2018-12-12T10:11:04Z
  file_id: '4857'
  file_name: IST-2017-754-v1+1_1-s2.0-S2211124716307768-main.pdf
  file_size: 3921947
  relation: main_file
file_date_updated: 2018-12-12T10:11:04Z
has_accepted_license: '1'
intvolume: '        16'
issue: '3'
language:
- iso: eng
month: '07'
oa: 1
oa_version: Published Version
page: 866 - 877
project:
- _id: 2529486C-B435-11E9-9278-68D0E5697425
  call_identifier: FWF
  grant_number: T 560-B17
  name: Cell- and Tissue Mechanics in Zebrafish Germ Layer Formation
- _id: 2527D5CC-B435-11E9-9278-68D0E5697425
  call_identifier: FWF
  grant_number: I 812-B12
  name: Cell Cortex and Germ Layer Formation in Zebrafish Gastrulation
- _id: 25548C20-B435-11E9-9278-68D0E5697425
  call_identifier: FP7
  grant_number: '303564'
  name: Microbial Ion Channels for Synthetic Neurobiology
publication: Cell Reports
publication_status: published
publisher: Cell Press
publist_id: '6275'
pubrep_id: '754'
quality_controlled: '1'
related_material:
  record:
  - id: '961'
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    status: public
  - id: '50'
    relation: dissertation_contains
    status: public
scopus_import: 1
status: public
title: Optogenetic control of nodal signaling reveals a temporal pattern of nodal
  signaling regulating cell fate specification during gastrulation
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 4435EBFC-F248-11E8-B48F-1D18A9856A87
volume: 16
year: '2016'
...
---
_id: '1239'
abstract:
- lang: eng
  text: Nonadherent polarized cells have been observed to have a pearlike, elongated
    shape. Using a minimal model that describes the cell cortex as a thin layer of
    contractile active gel, we show that the anisotropy of active stresses, controlled
    by cortical viscosity and filament ordering, can account for this morphology.
    The predicted shapes can be determined from the flow pattern only; they prove
    to be independent of the mechanism at the origin of the cortical flow, and are
    only weakly sensitive to the cytoplasmic rheology. In the case of actin flows
    resulting from a contractile instability, we propose a phase diagram of three-dimensional
    cell shapes that encompasses nonpolarized spherical, elongated, as well as oblate
    shapes, all of which have been observed in experiment.
acknowledgement: 'V. R. acknowledges support by the Austrian Science Fund (FWF): (Grant
  No. T560-B17).'
article_number: '028102'
author:
- first_name: Andrew
  full_name: Callan Jones, Andrew
  last_name: Callan Jones
- first_name: Verena
  full_name: Ruprecht, Verena
  id: 4D71A03A-F248-11E8-B48F-1D18A9856A87
  last_name: Ruprecht
  orcid: 0000-0003-4088-8633
- first_name: Stefan
  full_name: Wieser, Stefan
  id: 355AA5A0-F248-11E8-B48F-1D18A9856A87
  last_name: Wieser
  orcid: 0000-0002-2670-2217
- first_name: Carl-Philipp J
  full_name: Heisenberg, Carl-Philipp J
  id: 39427864-F248-11E8-B48F-1D18A9856A87
  last_name: Heisenberg
  orcid: 0000-0002-0912-4566
- first_name: Raphaël
  full_name: Voituriez, Raphaël
  last_name: Voituriez
citation:
  ama: Callan Jones A, Ruprecht V, Wieser S, Heisenberg C-PJ, Voituriez R. Cortical
    flow-driven shapes of nonadherent cells. <i>Physical Review Letters</i>. 2016;116(2).
    doi:<a href="https://doi.org/10.1103/PhysRevLett.116.028102">10.1103/PhysRevLett.116.028102</a>
  apa: Callan Jones, A., Ruprecht, V., Wieser, S., Heisenberg, C.-P. J., &#38; Voituriez,
    R. (2016). Cortical flow-driven shapes of nonadherent cells. <i>Physical Review
    Letters</i>. American Physical Society. <a href="https://doi.org/10.1103/PhysRevLett.116.028102">https://doi.org/10.1103/PhysRevLett.116.028102</a>
  chicago: Callan Jones, Andrew, Verena Ruprecht, Stefan Wieser, Carl-Philipp J Heisenberg,
    and Raphaël Voituriez. “Cortical Flow-Driven Shapes of Nonadherent Cells.” <i>Physical
    Review Letters</i>. American Physical Society, 2016. <a href="https://doi.org/10.1103/PhysRevLett.116.028102">https://doi.org/10.1103/PhysRevLett.116.028102</a>.
  ieee: A. Callan Jones, V. Ruprecht, S. Wieser, C.-P. J. Heisenberg, and R. Voituriez,
    “Cortical flow-driven shapes of nonadherent cells,” <i>Physical Review Letters</i>,
    vol. 116, no. 2. American Physical Society, 2016.
  ista: Callan Jones A, Ruprecht V, Wieser S, Heisenberg C-PJ, Voituriez R. 2016.
    Cortical flow-driven shapes of nonadherent cells. Physical Review Letters. 116(2),
    028102.
  mla: Callan Jones, Andrew, et al. “Cortical Flow-Driven Shapes of Nonadherent Cells.”
    <i>Physical Review Letters</i>, vol. 116, no. 2, 028102, American Physical Society,
    2016, doi:<a href="https://doi.org/10.1103/PhysRevLett.116.028102">10.1103/PhysRevLett.116.028102</a>.
  short: A. Callan Jones, V. Ruprecht, S. Wieser, C.-P.J. Heisenberg, R. Voituriez,
    Physical Review Letters 116 (2016).
date_created: 2018-12-11T11:50:53Z
date_published: 2016-01-15T00:00:00Z
date_updated: 2021-01-12T06:49:19Z
day: '15'
department:
- _id: CaHe
doi: 10.1103/PhysRevLett.116.028102
intvolume: '       116'
issue: '2'
language:
- iso: eng
month: '01'
oa_version: None
project:
- _id: 2529486C-B435-11E9-9278-68D0E5697425
  call_identifier: FWF
  grant_number: T 560-B17
  name: Cell- and Tissue Mechanics in Zebrafish Germ Layer Formation
publication: Physical Review Letters
publication_status: published
publisher: American Physical Society
publist_id: '6095'
quality_controlled: '1'
scopus_import: 1
status: public
title: Cortical flow-driven shapes of nonadherent cells
type: journal_article
user_id: 3E5EF7F0-F248-11E8-B48F-1D18A9856A87
volume: 116
year: '2016'
...
---
_id: '1537'
abstract:
- lang: eng
  text: 3D amoeboid cell migration is central to many developmental and disease-related
    processes such as cancer metastasis. Here, we identify a unique prototypic amoeboid
    cell migration mode in early zebrafish embryos, termed stable-bleb migration.
    Stable-bleb cells display an invariant polarized balloon-like shape with exceptional
    migration speed and persistence. Progenitor cells can be reversibly transformed
    into stable-bleb cells irrespective of their primary fate and motile characteristics
    by increasing myosin II activity through biochemical or mechanical stimuli. Using
    a combination of theory and experiments, we show that, in stable-bleb cells, cortical
    contractility fluctuations trigger a stochastic switch into amoeboid motility,
    and a positive feedback between cortical flows and gradients in contractility
    maintains stable-bleb cell polarization. We further show that rearward cortical
    flows drive stable-bleb cell migration in various adhesive and non-adhesive environments,
    unraveling a highly versatile amoeboid migration phenotype.
acknowledged_ssus:
- _id: SSU
acknowledgement: 'We would like to thank R. Hausschild and E. Papusheva for technical
  assistance and the service facilities at the IST Austria for continuous support.
  The caRhoA plasmid was a kind gift of T. Kudoh and A. Takesono. We thank M. Piel
  and E. Paluch for exchanging unpublished data. '
author:
- first_name: Verena
  full_name: Ruprecht, Verena
  id: 4D71A03A-F248-11E8-B48F-1D18A9856A87
  last_name: Ruprecht
  orcid: 0000-0003-4088-8633
- first_name: Stefan
  full_name: Wieser, Stefan
  id: 355AA5A0-F248-11E8-B48F-1D18A9856A87
  last_name: Wieser
  orcid: 0000-0002-2670-2217
- first_name: Andrew
  full_name: Callan Jones, Andrew
  last_name: Callan Jones
- first_name: Michael
  full_name: Smutny, Michael
  id: 3FE6E4E8-F248-11E8-B48F-1D18A9856A87
  last_name: Smutny
  orcid: 0000-0002-5920-9090
- first_name: Hitoshi
  full_name: Morita, Hitoshi
  id: 4C6E54C6-F248-11E8-B48F-1D18A9856A87
  last_name: Morita
- first_name: Keisuke
  full_name: Sako, Keisuke
  id: 3BED66BE-F248-11E8-B48F-1D18A9856A87
  last_name: Sako
  orcid: 0000-0002-6453-8075
- first_name: Vanessa
  full_name: Barone, Vanessa
  id: 419EECCC-F248-11E8-B48F-1D18A9856A87
  last_name: Barone
  orcid: 0000-0003-2676-3367
- first_name: Monika
  full_name: Ritsch Marte, Monika
  last_name: Ritsch Marte
- first_name: Michael K
  full_name: Sixt, Michael K
  id: 41E9FBEA-F248-11E8-B48F-1D18A9856A87
  last_name: Sixt
  orcid: 0000-0002-6620-9179
- first_name: Raphaël
  full_name: Voituriez, Raphaël
  last_name: Voituriez
- first_name: Carl-Philipp J
  full_name: Heisenberg, Carl-Philipp J
  id: 39427864-F248-11E8-B48F-1D18A9856A87
  last_name: Heisenberg
  orcid: 0000-0002-0912-4566
citation:
  ama: Ruprecht V, Wieser S, Callan Jones A, et al. Cortical contractility triggers
    a stochastic switch to fast amoeboid cell motility. <i>Cell</i>. 2015;160(4):673-685.
    doi:<a href="https://doi.org/10.1016/j.cell.2015.01.008">10.1016/j.cell.2015.01.008</a>
  apa: Ruprecht, V., Wieser, S., Callan Jones, A., Smutny, M., Morita, H., Sako, K.,
    … Heisenberg, C.-P. J. (2015). Cortical contractility triggers a stochastic switch
    to fast amoeboid cell motility. <i>Cell</i>. Cell Press. <a href="https://doi.org/10.1016/j.cell.2015.01.008">https://doi.org/10.1016/j.cell.2015.01.008</a>
  chicago: Ruprecht, Verena, Stefan Wieser, Andrew Callan Jones, Michael Smutny, Hitoshi
    Morita, Keisuke Sako, Vanessa Barone, et al. “Cortical Contractility Triggers
    a Stochastic Switch to Fast Amoeboid Cell Motility.” <i>Cell</i>. Cell Press,
    2015. <a href="https://doi.org/10.1016/j.cell.2015.01.008">https://doi.org/10.1016/j.cell.2015.01.008</a>.
  ieee: V. Ruprecht <i>et al.</i>, “Cortical contractility triggers a stochastic switch
    to fast amoeboid cell motility,” <i>Cell</i>, vol. 160, no. 4. Cell Press, pp.
    673–685, 2015.
  ista: Ruprecht V, Wieser S, Callan Jones A, Smutny M, Morita H, Sako K, Barone V,
    Ritsch Marte M, Sixt MK, Voituriez R, Heisenberg C-PJ. 2015. Cortical contractility
    triggers a stochastic switch to fast amoeboid cell motility. Cell. 160(4), 673–685.
  mla: Ruprecht, Verena, et al. “Cortical Contractility Triggers a Stochastic Switch
    to Fast Amoeboid Cell Motility.” <i>Cell</i>, vol. 160, no. 4, Cell Press, 2015,
    pp. 673–85, doi:<a href="https://doi.org/10.1016/j.cell.2015.01.008">10.1016/j.cell.2015.01.008</a>.
  short: V. Ruprecht, S. Wieser, A. Callan Jones, M. Smutny, H. Morita, K. Sako, V.
    Barone, M. Ritsch Marte, M.K. Sixt, R. Voituriez, C.-P.J. Heisenberg, Cell 160
    (2015) 673–685.
date_created: 2018-12-11T11:52:35Z
date_published: 2015-02-12T00:00:00Z
date_updated: 2023-09-07T12:05:08Z
day: '12'
ddc:
- '570'
department:
- _id: CaHe
- _id: MiSi
doi: 10.1016/j.cell.2015.01.008
file:
- access_level: open_access
  checksum: 228d3edf40627d897b3875088a0ac51f
  content_type: application/pdf
  creator: system
  date_created: 2018-12-12T10:13:21Z
  date_updated: 2020-07-14T12:45:01Z
  file_id: '5003'
  file_name: IST-2016-484-v1+1_1-s2.0-S0092867415000094-main.pdf
  file_size: 4362653
  relation: main_file
file_date_updated: 2020-07-14T12:45:01Z
has_accepted_license: '1'
intvolume: '       160'
issue: '4'
language:
- iso: eng
month: '02'
oa: 1
oa_version: Published Version
page: 673 - 685
project:
- _id: 2529486C-B435-11E9-9278-68D0E5697425
  call_identifier: FWF
  grant_number: T 560-B17
  name: Cell- and Tissue Mechanics in Zebrafish Germ Layer Formation
- _id: 2527D5CC-B435-11E9-9278-68D0E5697425
  call_identifier: FWF
  grant_number: I 812-B12
  name: Cell Cortex and Germ Layer Formation in Zebrafish Gastrulation
publication: Cell
publication_status: published
publisher: Cell Press
publist_id: '5634'
pubrep_id: '484'
quality_controlled: '1'
related_material:
  record:
  - id: '961'
    relation: dissertation_contains
    status: public
scopus_import: 1
status: public
title: Cortical contractility triggers a stochastic switch to fast amoeboid cell motility
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 4435EBFC-F248-11E8-B48F-1D18A9856A87
volume: 160
year: '2015'
...
---
_id: '1553'
abstract:
- lang: eng
  text: Cell movement has essential functions in development, immunity, and cancer.
    Various cell migration patterns have been reported, but no general rule has emerged
    so far. Here, we show on the basis of experimental data in vitro and in vivo that
    cell persistence, which quantifies the straightness of trajectories, is robustly
    coupled to cell migration speed. We suggest that this universal coupling constitutes
    a generic law of cell migration, which originates in the advection of polarity
    cues by an actin cytoskeleton undergoing flows at the cellular scale. Our analysis
    relies on a theoretical model that we validate by measuring the persistence of
    cells upon modulation of actin flow speeds and upon optogenetic manipulation of
    the binding of an actin regulator to actin filaments. Beyond the quantitative
    prediction of the coupling, the model yields a generic phase diagram of cellular
    trajectories, which recapitulates the full range of observed migration patterns.
author:
- first_name: Paolo
  full_name: Maiuri, Paolo
  last_name: Maiuri
- first_name: Jean
  full_name: Rupprecht, Jean
  last_name: Rupprecht
- first_name: Stefan
  full_name: Wieser, Stefan
  id: 355AA5A0-F248-11E8-B48F-1D18A9856A87
  last_name: Wieser
  orcid: 0000-0002-2670-2217
- first_name: Verena
  full_name: Ruprecht, Verena
  id: 4D71A03A-F248-11E8-B48F-1D18A9856A87
  last_name: Ruprecht
  orcid: 0000-0003-4088-8633
- first_name: Olivier
  full_name: Bénichou, Olivier
  last_name: Bénichou
- first_name: Nicolas
  full_name: Carpi, Nicolas
  last_name: Carpi
- first_name: Mathieu
  full_name: Coppey, Mathieu
  last_name: Coppey
- first_name: Simon
  full_name: De Beco, Simon
  last_name: De Beco
- first_name: Nir
  full_name: Gov, Nir
  last_name: Gov
- first_name: Carl-Philipp J
  full_name: Heisenberg, Carl-Philipp J
  id: 39427864-F248-11E8-B48F-1D18A9856A87
  last_name: Heisenberg
  orcid: 0000-0002-0912-4566
- first_name: Carolina
  full_name: Lage Crespo, Carolina
  last_name: Lage Crespo
- first_name: Franziska
  full_name: Lautenschlaeger, Franziska
  last_name: Lautenschlaeger
- first_name: Maël
  full_name: Le Berre, Maël
  last_name: Le Berre
- first_name: Ana
  full_name: Lennon Duménil, Ana
  last_name: Lennon Duménil
- first_name: Matthew
  full_name: Raab, Matthew
  last_name: Raab
- first_name: Hawa
  full_name: Thiam, Hawa
  last_name: Thiam
- first_name: Matthieu
  full_name: Piel, Matthieu
  last_name: Piel
- first_name: Michael K
  full_name: Sixt, Michael K
  id: 41E9FBEA-F248-11E8-B48F-1D18A9856A87
  last_name: Sixt
  orcid: 0000-0002-6620-9179
- first_name: Raphaël
  full_name: Voituriez, Raphaël
  last_name: Voituriez
citation:
  ama: Maiuri P, Rupprecht J, Wieser S, et al. Actin flows mediate a universal coupling
    between cell speed and cell persistence. <i>Cell</i>. 2015;161(2):374-386. doi:<a
    href="https://doi.org/10.1016/j.cell.2015.01.056">10.1016/j.cell.2015.01.056</a>
  apa: Maiuri, P., Rupprecht, J., Wieser, S., Ruprecht, V., Bénichou, O., Carpi, N.,
    … Voituriez, R. (2015). Actin flows mediate a universal coupling between cell
    speed and cell persistence. <i>Cell</i>. Cell Press. <a href="https://doi.org/10.1016/j.cell.2015.01.056">https://doi.org/10.1016/j.cell.2015.01.056</a>
  chicago: Maiuri, Paolo, Jean Rupprecht, Stefan Wieser, Verena Ruprecht, Olivier
    Bénichou, Nicolas Carpi, Mathieu Coppey, et al. “Actin Flows Mediate a Universal
    Coupling between Cell Speed and Cell Persistence.” <i>Cell</i>. Cell Press, 2015.
    <a href="https://doi.org/10.1016/j.cell.2015.01.056">https://doi.org/10.1016/j.cell.2015.01.056</a>.
  ieee: P. Maiuri <i>et al.</i>, “Actin flows mediate a universal coupling between
    cell speed and cell persistence,” <i>Cell</i>, vol. 161, no. 2. Cell Press, pp.
    374–386, 2015.
  ista: Maiuri P, Rupprecht J, Wieser S, Ruprecht V, Bénichou O, Carpi N, Coppey M,
    De Beco S, Gov N, Heisenberg C-PJ, Lage Crespo C, Lautenschlaeger F, Le Berre
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    161(2), 374–386.
  mla: Maiuri, Paolo, et al. “Actin Flows Mediate a Universal Coupling between Cell
    Speed and Cell Persistence.” <i>Cell</i>, vol. 161, no. 2, Cell Press, 2015, pp.
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  short: P. Maiuri, J. Rupprecht, S. Wieser, V. Ruprecht, O. Bénichou, N. Carpi, M.
    Coppey, S. De Beco, N. Gov, C.-P.J. Heisenberg, C. Lage Crespo, F. Lautenschlaeger,
    M. Le Berre, A. Lennon Duménil, M. Raab, H. Thiam, M. Piel, M.K. Sixt, R. Voituriez,
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date_created: 2018-12-11T11:52:41Z
date_published: 2015-04-09T00:00:00Z
date_updated: 2021-01-12T06:51:33Z
day: '09'
department:
- _id: MiSi
- _id: CaHe
doi: 10.1016/j.cell.2015.01.056
ec_funded: 1
intvolume: '       161'
issue: '2'
language:
- iso: eng
month: '04'
oa_version: None
page: 374 - 386
project:
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  call_identifier: FWF
  grant_number: T 560-B17
  name: Cell- and Tissue Mechanics in Zebrafish Germ Layer Formation
- _id: 25A603A2-B435-11E9-9278-68D0E5697425
  call_identifier: FP7
  grant_number: '281556'
  name: Cytoskeletal force generation and force transduction of migrating leukocytes
    (EU)
- _id: 25ABD200-B435-11E9-9278-68D0E5697425
  grant_number: RGP0058/2011
  name: 'Cell migration in complex environments: from in vivo experiments to theoretical
    models'
publication: Cell
publication_status: published
publisher: Cell Press
publist_id: '5618'
quality_controlled: '1'
scopus_import: 1
status: public
title: Actin flows mediate a universal coupling between cell speed and cell persistence
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 161
year: '2015'
...