---
_id: '1067'
abstract:
- lang: eng
  text: Embryo morphogenesis relies on highly coordinated movements of different tissues.
    However, remarkably little is known about how tissues coordinate their movements
    to shape the embryo. In zebrafish embryogenesis, coordinated tissue movements
    first become apparent during “doming,” when the blastoderm begins to spread over
    the yolk sac, a process involving coordinated epithelial surface cell layer expansion
    and mesenchymal deep cell intercalations. Here, we find that active surface cell
    expansion represents the key process coordinating tissue movements during doming.
    By using a combination of theory and experiments, we show that epithelial surface
    cells not only trigger blastoderm expansion by reducing tissue surface tension,
    but also drive blastoderm thinning by inducing tissue contraction through radial
    deep cell intercalations. Thus, coordinated tissue expansion and thinning during
    doming relies on surface cells simultaneously controlling tissue surface tension
    and radial tissue contraction.
acknowledged_ssus:
- _id: PreCl
article_processing_charge: No
author:
- first_name: Hitoshi
  full_name: Morita, Hitoshi
  id: 4C6E54C6-F248-11E8-B48F-1D18A9856A87
  last_name: Morita
- first_name: Silvia
  full_name: Grigolon, Silvia
  last_name: Grigolon
- first_name: Martin
  full_name: Bock, Martin
  last_name: Bock
- first_name: Gabriel
  full_name: Krens, Gabriel
  id: 2B819732-F248-11E8-B48F-1D18A9856A87
  last_name: Krens
  orcid: 0000-0003-4761-5996
- first_name: Guillaume
  full_name: Salbreux, Guillaume
  last_name: Salbreux
- first_name: Carl-Philipp J
  full_name: Heisenberg, Carl-Philipp J
  id: 39427864-F248-11E8-B48F-1D18A9856A87
  last_name: Heisenberg
  orcid: 0000-0002-0912-4566
citation:
  ama: Morita H, Grigolon S, Bock M, Krens G, Salbreux G, Heisenberg C-PJ. The physical
    basis of coordinated tissue spreading in zebrafish gastrulation. <i>Developmental
    Cell</i>. 2017;40(4):354-366. doi:<a href="https://doi.org/10.1016/j.devcel.2017.01.010">10.1016/j.devcel.2017.01.010</a>
  apa: Morita, H., Grigolon, S., Bock, M., Krens, G., Salbreux, G., &#38; Heisenberg,
    C.-P. J. (2017). The physical basis of coordinated tissue spreading in zebrafish
    gastrulation. <i>Developmental Cell</i>. Cell Press. <a href="https://doi.org/10.1016/j.devcel.2017.01.010">https://doi.org/10.1016/j.devcel.2017.01.010</a>
  chicago: Morita, Hitoshi, Silvia Grigolon, Martin Bock, Gabriel Krens, Guillaume
    Salbreux, and Carl-Philipp J Heisenberg. “The Physical Basis of Coordinated Tissue
    Spreading in Zebrafish Gastrulation.” <i>Developmental Cell</i>. Cell Press, 2017.
    <a href="https://doi.org/10.1016/j.devcel.2017.01.010">https://doi.org/10.1016/j.devcel.2017.01.010</a>.
  ieee: H. Morita, S. Grigolon, M. Bock, G. Krens, G. Salbreux, and C.-P. J. Heisenberg,
    “The physical basis of coordinated tissue spreading in zebrafish gastrulation,”
    <i>Developmental Cell</i>, vol. 40, no. 4. Cell Press, pp. 354–366, 2017.
  ista: Morita H, Grigolon S, Bock M, Krens G, Salbreux G, Heisenberg C-PJ. 2017.
    The physical basis of coordinated tissue spreading in zebrafish gastrulation.
    Developmental Cell. 40(4), 354–366.
  mla: Morita, Hitoshi, et al. “The Physical Basis of Coordinated Tissue Spreading
    in Zebrafish Gastrulation.” <i>Developmental Cell</i>, vol. 40, no. 4, Cell Press,
    2017, pp. 354–66, doi:<a href="https://doi.org/10.1016/j.devcel.2017.01.010">10.1016/j.devcel.2017.01.010</a>.
  short: H. Morita, S. Grigolon, M. Bock, G. Krens, G. Salbreux, C.-P.J. Heisenberg,
    Developmental Cell 40 (2017) 354–366.
date_created: 2018-12-11T11:49:58Z
date_published: 2017-02-27T00:00:00Z
date_updated: 2023-09-20T12:06:27Z
day: '27'
ddc:
- '572'
- '597'
department:
- _id: CaHe
doi: 10.1016/j.devcel.2017.01.010
ec_funded: 1
external_id:
  isi:
  - '000395368300007'
file:
- access_level: open_access
  content_type: application/pdf
  creator: system
  date_created: 2018-12-12T10:10:57Z
  date_updated: 2018-12-12T10:10:57Z
  file_id: '4849'
  file_name: IST-2017-869-v1+1_1-s2.0-S1534580717300370-main.pdf
  file_size: 6866187
  relation: main_file
file_date_updated: 2018-12-12T10:10:57Z
has_accepted_license: '1'
intvolume: '        40'
isi: 1
issue: '4'
language:
- iso: eng
month: '02'
oa: 1
oa_version: Published Version
page: 354 - 366
project:
- _id: 2524F500-B435-11E9-9278-68D0E5697425
  call_identifier: FP7
  grant_number: '201439'
  name: Developing High-Throughput Bioassays for Human Cancers in Zebrafish
publication: Developmental Cell
publication_identifier:
  issn:
  - '15345807'
publication_status: published
publisher: Cell Press
publist_id: '6320'
pubrep_id: '869'
quality_controlled: '1'
scopus_import: '1'
status: public
title: The physical basis of coordinated tissue spreading in zebrafish gastrulation
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 40
year: '2017'
...
---
_id: '943'
abstract:
- lang: eng
  text: Like many developing tissues, the vertebrate neural tube is patterned by antiparallel
    morphogen gradients. To understand how these inputs are interpreted, we measured
    morphogen signaling and target gene expression in mouse embryos and chick ex vivo
    assays. From these data, we derived and validated a characteristic decoding map
    that relates morphogen input to the positional identity of neural progenitors.
    Analysis of the observed responses indicates that the underlying interpretation
    strategy minimizes patterning errors in response to the joint input of noisy opposing
    gradients. We reverse-engineered a transcriptional network that provides a mechanistic
    basis for the observed cell fate decisions and accounts for the precision and
    dynamics of pattern formation. Together, our data link opposing gradient dynamics
    in a growing tissue to precise pattern formation.
article_processing_charge: No
author:
- first_name: Marcin P
  full_name: Zagórski, Marcin P
  id: 343DA0DC-F248-11E8-B48F-1D18A9856A87
  last_name: Zagórski
  orcid: 0000-0001-7896-7762
- first_name: Yoji
  full_name: Tabata, Yoji
  last_name: Tabata
- first_name: Nathalie
  full_name: Brandenberg, Nathalie
  last_name: Brandenberg
- first_name: Matthias
  full_name: Lutolf, Matthias
  last_name: Lutolf
- first_name: Gasper
  full_name: Tkacik, Gasper
  id: 3D494DCA-F248-11E8-B48F-1D18A9856A87
  last_name: Tkacik
  orcid: 0000-0002-6699-1455
- first_name: Tobias
  full_name: Bollenbach, Tobias
  last_name: Bollenbach
- first_name: James
  full_name: Briscoe, James
  last_name: Briscoe
- first_name: Anna
  full_name: Kicheva, Anna
  id: 3959A2A0-F248-11E8-B48F-1D18A9856A87
  last_name: Kicheva
  orcid: 0000-0003-4509-4998
citation:
  ama: Zagórski MP, Tabata Y, Brandenberg N, et al. Decoding of position in the developing
    neural tube from antiparallel morphogen gradients. <i>Science</i>. 2017;356(6345):1379-1383.
    doi:<a href="https://doi.org/10.1126/science.aam5887">10.1126/science.aam5887</a>
  apa: Zagórski, M. P., Tabata, Y., Brandenberg, N., Lutolf, M., Tkačik, G., Bollenbach,
    T., … Kicheva, A. (2017). Decoding of position in the developing neural tube from
    antiparallel morphogen gradients. <i>Science</i>. American Association for the
    Advancement of Science. <a href="https://doi.org/10.1126/science.aam5887">https://doi.org/10.1126/science.aam5887</a>
  chicago: Zagórski, Marcin P, Yoji Tabata, Nathalie Brandenberg, Matthias Lutolf,
    Gašper Tkačik, Tobias Bollenbach, James Briscoe, and Anna Kicheva. “Decoding of
    Position in the Developing Neural Tube from Antiparallel Morphogen Gradients.”
    <i>Science</i>. American Association for the Advancement of Science, 2017. <a
    href="https://doi.org/10.1126/science.aam5887">https://doi.org/10.1126/science.aam5887</a>.
  ieee: M. P. Zagórski <i>et al.</i>, “Decoding of position in the developing neural
    tube from antiparallel morphogen gradients,” <i>Science</i>, vol. 356, no. 6345.
    American Association for the Advancement of Science, pp. 1379–1383, 2017.
  ista: Zagórski MP, Tabata Y, Brandenberg N, Lutolf M, Tkačik G, Bollenbach T, Briscoe
    J, Kicheva A. 2017. Decoding of position in the developing neural tube from antiparallel
    morphogen gradients. Science. 356(6345), 1379–1383.
  mla: Zagórski, Marcin P., et al. “Decoding of Position in the Developing Neural
    Tube from Antiparallel Morphogen Gradients.” <i>Science</i>, vol. 356, no. 6345,
    American Association for the Advancement of Science, 2017, pp. 1379–83, doi:<a
    href="https://doi.org/10.1126/science.aam5887">10.1126/science.aam5887</a>.
  short: M.P. Zagórski, Y. Tabata, N. Brandenberg, M. Lutolf, G. Tkačik, T. Bollenbach,
    J. Briscoe, A. Kicheva, Science 356 (2017) 1379–1383.
date_created: 2018-12-11T11:49:20Z
date_published: 2017-06-30T00:00:00Z
date_updated: 2023-09-26T15:38:05Z
day: '30'
department:
- _id: AnKi
- _id: GaTk
doi: 10.1126/science.aam5887
ec_funded: 1
external_id:
  isi:
  - '000404351500036'
  pmid:
  - '28663499'
intvolume: '       356'
isi: 1
issue: '6345'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5568706/
month: '06'
oa: 1
oa_version: Submitted Version
page: 1379 - 1383
pmid: 1
project:
- _id: 254E9036-B435-11E9-9278-68D0E5697425
  call_identifier: FWF
  grant_number: P28844-B27
  name: Biophysics of information processing in gene regulation
- _id: B6FC0238-B512-11E9-945C-1524E6697425
  call_identifier: H2020
  grant_number: '680037'
  name: Coordination of Patterning And Growth In the Spinal Cord
- _id: 25681D80-B435-11E9-9278-68D0E5697425
  call_identifier: FP7
  grant_number: '291734'
  name: International IST Postdoc Fellowship Programme
- _id: 2524F500-B435-11E9-9278-68D0E5697425
  call_identifier: FP7
  grant_number: '201439'
  name: Developing High-Throughput Bioassays for Human Cancers in Zebrafish
publication: Science
publication_identifier:
  issn:
  - '00368075'
publication_status: published
publisher: American Association for the Advancement of Science
publist_id: '6474'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Decoding of position in the developing neural tube from antiparallel morphogen
  gradients
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 356
year: '2017'
...