@article{1067,
  abstract     = {Embryo morphogenesis relies on highly coordinated movements of different tissues. However, remarkably little is known about how tissues coordinate their movements to shape the embryo. In zebrafish embryogenesis, coordinated tissue movements first become apparent during “doming,” when the blastoderm begins to spread over the yolk sac, a process involving coordinated epithelial surface cell layer expansion and mesenchymal deep cell intercalations. Here, we find that active surface cell expansion represents the key process coordinating tissue movements during doming. By using a combination of theory and experiments, we show that epithelial surface cells not only trigger blastoderm expansion by reducing tissue surface tension, but also drive blastoderm thinning by inducing tissue contraction through radial deep cell intercalations. Thus, coordinated tissue expansion and thinning during doming relies on surface cells simultaneously controlling tissue surface tension and radial tissue contraction.},
  author       = {Morita, Hitoshi and Grigolon, Silvia and Bock, Martin and Krens, Gabriel and Salbreux, Guillaume and Heisenberg, Carl-Philipp J},
  issn         = {15345807},
  journal      = {Developmental Cell},
  number       = {4},
  pages        = {354 -- 366},
  publisher    = {Cell Press},
  title        = {{The physical basis of coordinated tissue spreading in zebrafish gastrulation}},
  doi          = {10.1016/j.devcel.2017.01.010},
  volume       = {40},
  year         = {2017},
}

@article{943,
  abstract     = {Like many developing tissues, the vertebrate neural tube is patterned by antiparallel morphogen gradients. To understand how these inputs are interpreted, we measured morphogen signaling and target gene expression in mouse embryos and chick ex vivo assays. From these data, we derived and validated a characteristic decoding map that relates morphogen input to the positional identity of neural progenitors. Analysis of the observed responses indicates that the underlying interpretation strategy minimizes patterning errors in response to the joint input of noisy opposing gradients. We reverse-engineered a transcriptional network that provides a mechanistic basis for the observed cell fate decisions and accounts for the precision and dynamics of pattern formation. Together, our data link opposing gradient dynamics in a growing tissue to precise pattern formation.},
  author       = {Zagórski, Marcin P and Tabata, Yoji and Brandenberg, Nathalie and Lutolf, Matthias and Tkacik, Gasper and Bollenbach, Tobias and Briscoe, James and Kicheva, Anna},
  issn         = {00368075},
  journal      = {Science},
  number       = {6345},
  pages        = {1379 -- 1383},
  publisher    = {American Association for the Advancement of Science},
  title        = {{Decoding of position in the developing neural tube from antiparallel morphogen gradients}},
  doi          = {10.1126/science.aam5887},
  volume       = {356},
  year         = {2017},
}