---
_id: '12157'
abstract:
- lang: eng
  text: 'Polygenic adaptation is thought to be ubiquitous, yet remains poorly understood.
    Here, we model this process analytically, in the plausible setting of a highly
    polygenic, quantitative trait that experiences a sudden shift in the fitness optimum.
    We show how the mean phenotype changes over time, depending on the effect sizes
    of loci that contribute to variance in the trait, and characterize the allele
    dynamics at these loci. Notably, we describe the two phases of the allele dynamics:
    The first is a rapid phase, in which directional selection introduces small frequency
    differences between alleles whose effects are aligned with or opposed to the shift,
    ultimately leading to small differences in their probability of fixation during
    a second, longer phase, governed by stabilizing selection. As we discuss, key
    results should hold in more general settings and have important implications for
    efforts to identify the genetic basis of adaptation in humans and other species.'
acknowledgement: "We thank Guy Amster, Jeremy Berg, Nick Barton, Yuval Simons and
  Molly Przeworski for many helpful discussions, and Jeremy Berg, Graham Coop, Joachim
  Hermisson, Guillaume Martin, Will Milligan, Peter Ralph, Yuval Simons, Leo Speidel
  and Molly Przeworski for comments on the manuscript.\r\nNational Institutes of Health
  GM115889 Laura Katharine Hayward Guy Sella \r\nNational Institutes of Health GM121372
  Laura Katharine Hayward"
article_number: '66697'
article_processing_charge: No
article_type: original
author:
- first_name: Laura
  full_name: Hayward, Laura
  id: fc885ee5-24bf-11eb-ad7b-bcc5104c0c1b
  last_name: Hayward
- first_name: Guy
  full_name: Sella, Guy
  last_name: Sella
citation:
  ama: Hayward L, Sella G. Polygenic adaptation after a sudden change in environment.
    <i>eLife</i>. 2022;11. doi:<a href="https://doi.org/10.7554/elife.66697">10.7554/elife.66697</a>
  apa: Hayward, L., &#38; Sella, G. (2022). Polygenic adaptation after a sudden change
    in environment. <i>ELife</i>. eLife Sciences Publications. <a href="https://doi.org/10.7554/elife.66697">https://doi.org/10.7554/elife.66697</a>
  chicago: Hayward, Laura, and Guy Sella. “Polygenic Adaptation after a Sudden Change
    in Environment.” <i>ELife</i>. eLife Sciences Publications, 2022. <a href="https://doi.org/10.7554/elife.66697">https://doi.org/10.7554/elife.66697</a>.
  ieee: L. Hayward and G. Sella, “Polygenic adaptation after a sudden change in environment,”
    <i>eLife</i>, vol. 11. eLife Sciences Publications, 2022.
  ista: Hayward L, Sella G. 2022. Polygenic adaptation after a sudden change in environment.
    eLife. 11, 66697.
  mla: Hayward, Laura, and Guy Sella. “Polygenic Adaptation after a Sudden Change
    in Environment.” <i>ELife</i>, vol. 11, 66697, eLife Sciences Publications, 2022,
    doi:<a href="https://doi.org/10.7554/elife.66697">10.7554/elife.66697</a>.
  short: L. Hayward, G. Sella, ELife 11 (2022).
date_created: 2023-01-12T12:09:00Z
date_published: 2022-09-26T00:00:00Z
date_updated: 2023-08-04T09:04:58Z
day: '26'
ddc:
- '570'
department:
- _id: NiBa
doi: 10.7554/elife.66697
external_id:
  isi:
  - '000890735600001'
file:
- access_level: open_access
  checksum: 28de155b231ac1c8d4501c98b2fb359a
  content_type: application/pdf
  creator: dernst
  date_created: 2023-01-24T12:21:32Z
  date_updated: 2023-01-24T12:21:32Z
  file_id: '12363'
  file_name: 2022_eLife_Hayward.pdf
  file_size: 18935612
  relation: main_file
  success: 1
file_date_updated: 2023-01-24T12:21:32Z
has_accepted_license: '1'
intvolume: '        11'
isi: 1
keyword:
- General Immunology and Microbiology
- General Biochemistry
- Genetics and Molecular Biology
- General Medicine
- General Neuroscience
language:
- iso: eng
month: '09'
oa: 1
oa_version: Published Version
publication: eLife
publication_identifier:
  eissn:
  - 2050-084X
publication_status: published
publisher: eLife Sciences Publications
quality_controlled: '1'
scopus_import: '1'
status: public
title: Polygenic adaptation after a sudden change in environment
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 11
year: '2022'
...