---
_id: '14841'
abstract:
- lang: eng
  text: De novo heterozygous variants in KCNC2 encoding the voltage-gated potassium
    (K+) channel subunit Kv3.2 are a recently described cause of developmental and
    epileptic encephalopathy (DEE). A de novo variant in KCNC2 c.374G > A (p.Cys125Tyr)
    was identified via exome sequencing in a patient with DEE. Relative to wild-type
    Kv3.2, Kv3.2-p.Cys125Tyr induces K+ currents exhibiting a large hyperpolarizing
    shift in the voltage dependence of activation, accelerated activation, and delayed
    deactivation consistent with a relative stabilization of the open conformation,
    along with increased current density. Leveraging the cryogenic electron microscopy
    (cryo-EM) structure of Kv3.1, molecular dynamic simulations suggest that a strong
    π-π stacking interaction between the variant Tyr125 and Tyr156 in the α-6 helix
    of the T1 domain promotes a relative stabilization of the open conformation of
    the channel, which underlies the observed gain of function. A multicompartment
    computational model of a Kv3-expressing parvalbumin-positive cerebral cortex fast-spiking
    γ-aminobutyric acidergic (GABAergic) interneuron (PV-IN) demonstrates how the
    Kv3.2-Cys125Tyr variant impairs neuronal excitability and dysregulates inhibition
    in cerebral cortex circuits to explain the resulting epilepsy.
acknowledgement: This work was supported by an ERC Consolidator Grant (SYNAPSEEK)
  to T.P.V., the NOMIS Foundation through the NOMIS Fellowships program at IST Austria
  to C.B.C., a Jefferson Synaptic Biology Center Pilot Project Grant to M.C., NIH
  NINDS U54 NS108874 (PI, Alfred L. George), and NIH NINDS R01 NS122887 to E.M.G.
  The computations were enabled by resources provided by the Swedish National Infrastructure
  for Computing (SNIC) at the PDC Center for High-Performance Computing, KTH Royal
  Institute of Technology, partially funded by the Swedish Research Council through
  grant agreement no. 2018-05973. We thank Akshay Sridhar for the fruitful discussion
  of the project.
article_number: e2307776121
article_processing_charge: No
article_type: original
author:
- first_name: Jerome
  full_name: Clatot, Jerome
  last_name: Clatot
- first_name: Christopher
  full_name: Currin, Christopher
  id: e8321fc5-3091-11eb-8a53-83f309a11ac9
  last_name: Currin
  orcid: 0000-0002-4809-5059
- first_name: Qiansheng
  full_name: Liang, Qiansheng
  last_name: Liang
- first_name: Tanadet
  full_name: Pipatpolkai, Tanadet
  last_name: Pipatpolkai
- first_name: Shavonne L.
  full_name: Massey, Shavonne L.
  last_name: Massey
- first_name: Ingo
  full_name: Helbig, Ingo
  last_name: Helbig
- first_name: Lucie
  full_name: Delemotte, Lucie
  last_name: Delemotte
- first_name: Tim P
  full_name: Vogels, Tim P
  id: CB6FF8D2-008F-11EA-8E08-2637E6697425
  last_name: Vogels
  orcid: 0000-0003-3295-6181
- first_name: Manuel
  full_name: Covarrubias, Manuel
  last_name: Covarrubias
- first_name: Ethan M.
  full_name: Goldberg, Ethan M.
  last_name: Goldberg
citation:
  ama: Clatot J, Currin C, Liang Q, et al. A structurally precise mechanism links
    an epilepsy-associated KCNC2 potassium channel mutation to interneuron dysfunction.
    <i>Proceedings of the National Academy of Sciences of the United States of America</i>.
    2024;121(3). doi:<a href="https://doi.org/10.1073/pnas.2307776121">10.1073/pnas.2307776121</a>
  apa: Clatot, J., Currin, C., Liang, Q., Pipatpolkai, T., Massey, S. L., Helbig,
    I., … Goldberg, E. M. (2024). A structurally precise mechanism links an epilepsy-associated
    KCNC2 potassium channel mutation to interneuron dysfunction. <i>Proceedings of
    the National Academy of Sciences of the United States of America</i>. Proceedings
    of the National Academy of Sciences. <a href="https://doi.org/10.1073/pnas.2307776121">https://doi.org/10.1073/pnas.2307776121</a>
  chicago: Clatot, Jerome, Christopher Currin, Qiansheng Liang, Tanadet Pipatpolkai,
    Shavonne L. Massey, Ingo Helbig, Lucie Delemotte, Tim P Vogels, Manuel Covarrubias,
    and Ethan M. Goldberg. “A Structurally Precise Mechanism Links an Epilepsy-Associated
    KCNC2 Potassium Channel Mutation to Interneuron Dysfunction.” <i>Proceedings of
    the National Academy of Sciences of the United States of America</i>. Proceedings
    of the National Academy of Sciences, 2024. <a href="https://doi.org/10.1073/pnas.2307776121">https://doi.org/10.1073/pnas.2307776121</a>.
  ieee: J. Clatot <i>et al.</i>, “A structurally precise mechanism links an epilepsy-associated
    KCNC2 potassium channel mutation to interneuron dysfunction,” <i>Proceedings of
    the National Academy of Sciences of the United States of America</i>, vol. 121,
    no. 3. Proceedings of the National Academy of Sciences, 2024.
  ista: Clatot J, Currin C, Liang Q, Pipatpolkai T, Massey SL, Helbig I, Delemotte
    L, Vogels TP, Covarrubias M, Goldberg EM. 2024. A structurally precise mechanism
    links an epilepsy-associated KCNC2 potassium channel mutation to interneuron dysfunction.
    Proceedings of the National Academy of Sciences of the United States of America.
    121(3), e2307776121.
  mla: Clatot, Jerome, et al. “A Structurally Precise Mechanism Links an Epilepsy-Associated
    KCNC2 Potassium Channel Mutation to Interneuron Dysfunction.” <i>Proceedings of
    the National Academy of Sciences of the United States of America</i>, vol. 121,
    no. 3, e2307776121, Proceedings of the National Academy of Sciences, 2024, doi:<a
    href="https://doi.org/10.1073/pnas.2307776121">10.1073/pnas.2307776121</a>.
  short: J. Clatot, C. Currin, Q. Liang, T. Pipatpolkai, S.L. Massey, I. Helbig, L.
    Delemotte, T.P. Vogels, M. Covarrubias, E.M. Goldberg, Proceedings of the National
    Academy of Sciences of the United States of America 121 (2024).
date_created: 2024-01-21T23:00:56Z
date_published: 2024-01-16T00:00:00Z
date_updated: 2024-01-23T10:20:40Z
day: '16'
department:
- _id: TiVo
doi: 10.1073/pnas.2307776121
ec_funded: 1
external_id:
  pmid:
  - '38194456'
intvolume: '       121'
issue: '3'
language:
- iso: eng
month: '01'
oa_version: None
pmid: 1
project:
- _id: 0aacfa84-070f-11eb-9043-d7eb2c709234
  call_identifier: H2020
  grant_number: '819603'
  name: Learning the shape of synaptic plasticity rules for neuronal architectures
    and function through machine learning.
publication: Proceedings of the National Academy of Sciences of the United States
  of America
publication_identifier:
  eissn:
  - 1091-6490
publication_status: published
publisher: Proceedings of the National Academy of Sciences
quality_controlled: '1'
related_material:
  link:
  - relation: software
    url: 'https://github.com/ChrisCurrin/pv-kcnc2 '
scopus_import: '1'
status: public
title: A structurally precise mechanism links an epilepsy-associated KCNC2 potassium
  channel mutation to interneuron dysfunction
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 121
year: '2024'
...
---
_id: '14993'
abstract:
- lang: eng
  text: "Traditional top-down approaches for global health have historically failed
    to achieve social progress (Hoffman et al., 2015; Hoffman & Røttingen, 2015).
    Recently, however, a more holistic, multi-level approach termed One Health (OH)
    (Osterhaus et al., 2020) is being adopted. Several sets of challenges have been
    identified for the implementation of OH (dos S. Ribeiro et al., 2019), including
    policy and funding, education and training, and multi-actor, multi-domain, and
    multi-level collaborations. These exist despite the increasing accessibility to\r\nknowledge
    and digital collaborative research tools through the internet. To address some
    of these challenges, we propose a general framework for grassroots community-based
    means of participatory research. Additionally, we present a specific roadmap to
    create a Machine Learning for Global Health community in Africa. The proposed
    framework aims to enable any small group of individuals with scarce resources
    to build and sustain an online community within approximately two years. We provide
    a discussion on the potential impact of the proposed framework for global health
    research collaborations."
acknowledgement: "Houcemeddine Turki’s contributions to this final output have been
  funded through the Adapting\r\nWikidata to support clinical practice using Data
  Science, Semantic Web and Machine Learning\r\nproject, which is part of the Wikimedia
  Research Fund maintained by the Wikimedia Foundation in San Francisco, California,
  United States of America."
article_processing_charge: No
author:
- first_name: Christopher
  full_name: Currin, Christopher
  id: e8321fc5-3091-11eb-8a53-83f309a11ac9
  last_name: Currin
  orcid: 0000-0002-4809-5059
- first_name: Mercy Nyamewaa
  full_name: Asiedu , Mercy Nyamewaa
  last_name: 'Asiedu '
- first_name: Chris
  full_name: Fourie, Chris
  last_name: Fourie
- first_name: Benjamin
  full_name: Rosman, Benjamin
  last_name: Rosman
- first_name: Houcemeddine
  full_name: Turki, Houcemeddine
  last_name: Turki
- first_name: Atnafu
  full_name: Lambebo Tonja, Atnafu
  last_name: Lambebo Tonja
- first_name: Jade
  full_name: Abbott, Jade
  last_name: Abbott
- first_name: Marvellous
  full_name: Ajala, Marvellous
  last_name: Ajala
- first_name: Sadiq Adewale
  full_name: Adedayo, Sadiq Adewale
  last_name: Adedayo
- first_name: Chris Chinenye
  full_name: Emezue, Chris Chinenye
  last_name: Emezue
- first_name: Daphne
  full_name: Machangara, Daphne
  last_name: Machangara
citation:
  ama: 'Currin C, Asiedu  MN, Fourie C, et al. A framework for grassroots research
    collaboration in machine learning and global health. In: <i>1st Workshop on Machine
    Learning &#38; Global Health</i>. OpenReview; 2023.'
  apa: 'Currin, C., Asiedu , M. N., Fourie, C., Rosman, B., Turki, H., Lambebo Tonja,
    A., … Machangara, D. (2023). A framework for grassroots research collaboration
    in machine learning and global health. In <i>1st Workshop on Machine Learning
    &#38; Global Health</i>. Kigali, Rwanda: OpenReview.'
  chicago: Currin, Christopher, Mercy Nyamewaa Asiedu , Chris Fourie, Benjamin Rosman,
    Houcemeddine Turki, Atnafu Lambebo Tonja, Jade Abbott, et al. “A Framework for
    Grassroots Research Collaboration in Machine Learning and Global Health.” In <i>1st
    Workshop on Machine Learning &#38; Global Health</i>. OpenReview, 2023.
  ieee: C. Currin <i>et al.</i>, “A framework for grassroots research collaboration
    in machine learning and global health,” in <i>1st Workshop on Machine Learning
    &#38; Global Health</i>, Kigali, Rwanda, 2023.
  ista: 'Currin C, Asiedu  MN, Fourie C, Rosman B, Turki H, Lambebo Tonja A, Abbott
    J, Ajala M, Adedayo SA, Emezue CC, Machangara D. 2023. A framework for grassroots
    research collaboration in machine learning and global health. 1st Workshop on
    Machine Learning &#38; Global Health. ICLR: International Conference on Learning
    Representations.'
  mla: Currin, Christopher, et al. “A Framework for Grassroots Research Collaboration
    in Machine Learning and Global Health.” <i>1st Workshop on Machine Learning &#38;
    Global Health</i>, OpenReview, 2023.
  short: C. Currin, M.N. Asiedu , C. Fourie, B. Rosman, H. Turki, A. Lambebo Tonja,
    J. Abbott, M. Ajala, S.A. Adedayo, C.C. Emezue, D. Machangara, in:, 1st Workshop
    on Machine Learning &#38; Global Health, OpenReview, 2023.
conference:
  end_date: 2023-05-05
  location: Kigali, Rwanda
  name: 'ICLR: International Conference on Learning Representations'
  start_date: 2023-05-05
date_created: 2024-02-14T15:11:48Z
date_published: 2023-03-02T00:00:00Z
date_updated: 2024-02-28T12:12:00Z
day: '02'
department:
- _id: TiVo
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://openreview.net/forum?id=jHY_G91R880
month: '03'
oa: 1
oa_version: Published Version
publication: 1st Workshop on Machine Learning & Global Health
publication_status: published
publisher: OpenReview
quality_controlled: '1'
status: public
title: A framework for grassroots research collaboration in machine learning and global
  health
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2023'
...
---
_id: '12866'
abstract:
- lang: eng
  text: "Autism spectrum disorder (ASD) and epilepsy are frequently comorbid neurodevelopmental
    disorders. Extensive research has demonstrated shared pathological pathways, etiologies,
    and phenotypes. Many risk factors for these disorders, like genetic mutations
    and environmental pressures, are linked to changes in childhood brain development,
    which is a critical period for their manifestation.\r\nDecades of research have
    yielded many signatures for ASD and epilepsy, some shared and others unique or
    opposing. The anatomical, physiological, and behavioral correlates of these disorders
    are discussed in this chapter in the context of understanding shared pathological
    pathways. We end with important takeaways on the presentation, prevention, intervention,
    and policy changes for ASD and epilepsy. This chapter aims to explore the complexity
    of these disorders, both in etiology and phenotypes, with the further goal of
    appreciating the expanse of unknowns still to explore about the brain."
alternative_title:
- 'Vol. 1: Biological Development and Physical Health'
article_processing_charge: No
author:
- first_name: Christopher
  full_name: Currin, Christopher
  id: e8321fc5-3091-11eb-8a53-83f309a11ac9
  last_name: Currin
  orcid: 0000-0002-4809-5059
- first_name: Chad
  full_name: Beyer, Chad
  last_name: Beyer
citation:
  ama: 'Currin C, Beyer C. Altered childhood brain development in autism and epilepsy.
    In: Halpern-Felsher B, ed. <i>Encyclopedia of Child and Adolescent Health</i>.
    1st ed. Elsevier; 2023:86-98. doi:<a href="https://doi.org/10.1016/b978-0-12-818872-9.00129-1">10.1016/b978-0-12-818872-9.00129-1</a>'
  apa: Currin, C., &#38; Beyer, C. (2023). Altered childhood brain development in
    autism and epilepsy. In B. Halpern-Felsher (Ed.), <i>Encyclopedia of Child and
    Adolescent Health</i> (1st ed., pp. 86–98). Elsevier. <a href="https://doi.org/10.1016/b978-0-12-818872-9.00129-1">https://doi.org/10.1016/b978-0-12-818872-9.00129-1</a>
  chicago: Currin, Christopher, and Chad Beyer. “Altered Childhood Brain Development
    in Autism and Epilepsy.” In <i>Encyclopedia of Child and Adolescent Health</i>,
    edited by Bonnie Halpern-Felsher, 1st ed., 86–98. Elsevier, 2023. <a href="https://doi.org/10.1016/b978-0-12-818872-9.00129-1">https://doi.org/10.1016/b978-0-12-818872-9.00129-1</a>.
  ieee: C. Currin and C. Beyer, “Altered childhood brain development in autism and
    epilepsy,” in <i>Encyclopedia of Child and Adolescent Health</i>, 1st ed., B.
    Halpern-Felsher, Ed. Elsevier, 2023, pp. 86–98.
  ista: 'Currin C, Beyer C. 2023.Altered childhood brain development in autism and
    epilepsy. In: Encyclopedia of Child and Adolescent Health. Vol. 1: Biological
    Development and Physical Health, , 86–98.'
  mla: Currin, Christopher, and Chad Beyer. “Altered Childhood Brain Development in
    Autism and Epilepsy.” <i>Encyclopedia of Child and Adolescent Health</i>, edited
    by Bonnie Halpern-Felsher, 1st ed., Elsevier, 2023, pp. 86–98, doi:<a href="https://doi.org/10.1016/b978-0-12-818872-9.00129-1">10.1016/b978-0-12-818872-9.00129-1</a>.
  short: C. Currin, C. Beyer, in:, B. Halpern-Felsher (Ed.), Encyclopedia of Child
    and Adolescent Health, 1st ed., Elsevier, 2023, pp. 86–98.
date_created: 2023-04-25T07:52:43Z
date_published: 2023-02-01T00:00:00Z
date_updated: 2023-04-25T09:25:40Z
day: '01'
department:
- _id: TiVo
doi: 10.1016/b978-0-12-818872-9.00129-1
edition: '1'
editor:
- first_name: Bonnie
  full_name: Halpern-Felsher, Bonnie
  last_name: Halpern-Felsher
language:
- iso: eng
month: '02'
oa_version: None
page: 86-98
publication: Encyclopedia of Child and Adolescent Health
publication_identifier:
  isbn:
  - '9780128188736'
publication_status: published
publisher: Elsevier
quality_controlled: '1'
status: public
title: Altered childhood brain development in autism and epilepsy
type: book_chapter
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2023'
...
---
_id: '11143'
abstract:
- lang: eng
  text: 'Dravet syndrome is a neurodevelopmental disorder characterized by epilepsy,
    intellectual disability, and sudden death due to pathogenic variants in SCN1A
    with loss of function of the sodium channel subunit Nav1.1. Nav1.1-expressing
    parvalbumin GABAergic interneurons (PV-INs) from young Scn1a+/− mice show impaired
    action potential generation. An approach assessing PV-IN function in the same
    mice at two time points shows impaired spike generation in all Scn1a+/− mice at
    postnatal days (P) 16–21, whether deceased prior or surviving to P35, with normalization
    by P35 in surviving mice. However, PV-IN synaptic transmission is dysfunctional
    in young Scn1a+/− mice that did not survive and in Scn1a+/− mice ≥ P35. Modeling
    confirms that PV-IN axonal propagation is more sensitive to decreased sodium conductance
    than spike generation. These results demonstrate dynamic dysfunction in Dravet
    syndrome: combined abnormalities of PV-IN spike generation and propagation drives
    early disease severity, while ongoing dysfunction of synaptic transmission contributes
    to chronic pathology.'
acknowledgement: We would like to thank Bernardo Rudy, Joanna Mattis, and Laura Mcgarry
  for comments on a previous version of the manuscript; Xiaohong Zhang for expert
  technical support and mouse colony maintenance; Melody Cheng for assistance with
  generation of the graphical abstract; and Jennifer Kearney for the gift of Scn1a+/−
  mice. This work was supported by the National Institute of Neurological Disorders
  and Stroke of the National Institutes of Health under F31NS111803 (to K.M.G.) and
  K08NS097633 and R01NS110869 (to E.M.G.), the Dravet Syndrome Foundation (to A.S.),
  an ERC Consolidator Grant (SYNAPSEEK) (to T.P.V.), and the NOMIS Foundation through
  the NOMIS Fellowships program at IST Austria (to C.C.). The graphical abstract was
  prepared using BioRender software (BioRender.com).
article_number: '110580'
article_processing_charge: No
article_type: original
author:
- first_name: Keisuke
  full_name: Kaneko, Keisuke
  last_name: Kaneko
- first_name: Christopher
  full_name: Currin, Christopher
  id: e8321fc5-3091-11eb-8a53-83f309a11ac9
  last_name: Currin
  orcid: 0000-0002-4809-5059
- first_name: Kevin M.
  full_name: Goff, Kevin M.
  last_name: Goff
- first_name: Eric R.
  full_name: Wengert, Eric R.
  last_name: Wengert
- first_name: Ala
  full_name: Somarowthu, Ala
  last_name: Somarowthu
- first_name: Tim P
  full_name: Vogels, Tim P
  id: CB6FF8D2-008F-11EA-8E08-2637E6697425
  last_name: Vogels
  orcid: 0000-0003-3295-6181
- first_name: Ethan M.
  full_name: Goldberg, Ethan M.
  last_name: Goldberg
citation:
  ama: Kaneko K, Currin C, Goff KM, et al. Developmentally regulated impairment of
    parvalbumin interneuron synaptic transmission in an experimental model of Dravet
    syndrome. <i>Cell Reports</i>. 2022;38(13). doi:<a href="https://doi.org/10.1016/j.celrep.2022.110580">10.1016/j.celrep.2022.110580</a>
  apa: Kaneko, K., Currin, C., Goff, K. M., Wengert, E. R., Somarowthu, A., Vogels,
    T. P., &#38; Goldberg, E. M. (2022). Developmentally regulated impairment of parvalbumin
    interneuron synaptic transmission in an experimental model of Dravet syndrome.
    <i>Cell Reports</i>. Elsevier. <a href="https://doi.org/10.1016/j.celrep.2022.110580">https://doi.org/10.1016/j.celrep.2022.110580</a>
  chicago: Kaneko, Keisuke, Christopher Currin, Kevin M. Goff, Eric R. Wengert, Ala
    Somarowthu, Tim P Vogels, and Ethan M. Goldberg. “Developmentally Regulated Impairment
    of Parvalbumin Interneuron Synaptic Transmission in an Experimental Model of Dravet
    Syndrome.” <i>Cell Reports</i>. Elsevier, 2022. <a href="https://doi.org/10.1016/j.celrep.2022.110580">https://doi.org/10.1016/j.celrep.2022.110580</a>.
  ieee: K. Kaneko <i>et al.</i>, “Developmentally regulated impairment of parvalbumin
    interneuron synaptic transmission in an experimental model of Dravet syndrome,”
    <i>Cell Reports</i>, vol. 38, no. 13. Elsevier, 2022.
  ista: Kaneko K, Currin C, Goff KM, Wengert ER, Somarowthu A, Vogels TP, Goldberg
    EM. 2022. Developmentally regulated impairment of parvalbumin interneuron synaptic
    transmission in an experimental model of Dravet syndrome. Cell Reports. 38(13),
    110580.
  mla: Kaneko, Keisuke, et al. “Developmentally Regulated Impairment of Parvalbumin
    Interneuron Synaptic Transmission in an Experimental Model of Dravet Syndrome.”
    <i>Cell Reports</i>, vol. 38, no. 13, 110580, Elsevier, 2022, doi:<a href="https://doi.org/10.1016/j.celrep.2022.110580">10.1016/j.celrep.2022.110580</a>.
  short: K. Kaneko, C. Currin, K.M. Goff, E.R. Wengert, A. Somarowthu, T.P. Vogels,
    E.M. Goldberg, Cell Reports 38 (2022).
date_created: 2022-04-10T22:01:39Z
date_published: 2022-03-29T00:00:00Z
date_updated: 2023-08-03T06:32:55Z
day: '29'
ddc:
- '570'
department:
- _id: TiVo
doi: 10.1016/j.celrep.2022.110580
ec_funded: 1
external_id:
  isi:
  - '000779794000001'
file:
- access_level: open_access
  checksum: 49105c6c27c9af0f37f50a8bbb4d380d
  content_type: application/pdf
  creator: dernst
  date_created: 2022-04-15T11:00:58Z
  date_updated: 2022-04-15T11:00:58Z
  file_id: '11172'
  file_name: 2022_CellReports_Kaneko.pdf
  file_size: 4774216
  relation: main_file
  success: 1
file_date_updated: 2022-04-15T11:00:58Z
has_accepted_license: '1'
intvolume: '        38'
isi: 1
issue: '13'
language:
- iso: eng
month: '03'
oa: 1
oa_version: Published Version
project:
- _id: 0aacfa84-070f-11eb-9043-d7eb2c709234
  call_identifier: H2020
  grant_number: '819603'
  name: Learning the shape of synaptic plasticity rules for neuronal architectures
    and function through machine learning.
- _id: 9B861AAC-BA93-11EA-9121-9846C619BF3A
  name: NOMIS Fellowship Program
publication: Cell Reports
publication_identifier:
  eissn:
  - 2211-1247
publication_status: published
publisher: Elsevier
quality_controlled: '1'
scopus_import: '1'
status: public
title: Developmentally regulated impairment of parvalbumin interneuron synaptic transmission
  in an experimental model of Dravet syndrome
tmp:
  image: /images/cc_by_nc_nd.png
  legal_code_url: https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode
  name: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
    (CC BY-NC-ND 4.0)
  short: CC BY-NC-ND (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 38
year: '2022'
...
---
_id: '12225'
abstract:
- lang: eng
  text: In social networks, users often engage with like-minded peers. This selective
    exposure to opinions might result in echo chambers, i.e., political fragmentation
    and social polarization of user interactions. When echo chambers form, opinions
    have a bimodal distribution with two peaks on opposite sides. In certain issues,
    where either extreme positions contain a degree of misinformation, neutral consensus
    is preferable for promoting discourse. In this paper, we use an opinion dynamics
    model that naturally forms echo chambers in order to find a feedback mechanism
    that bridges these communities and leads to a neutral consensus. We introduce the
    <jats:italic>random dynamical nudge</jats:italic> (RDN), which presents each agent
    with input from a random selection of other agents’ opinions and does not require
    surveillance of every person’s opinions. Our computational results in two different
    models suggest that the RDN leads to a unimodal distribution of opinions centered
    around the neutral consensus. Furthermore, the RDN is effective both for preventing
    the formation of echo chambers and also for depolarizing existing echo chambers.
    Due to the simple and robust nature of the RDN, social media networks might be
    able to implement a version of this self-feedback mechanism, when appropriate,
    to prevent the segregation of online communities on complex social issues.
acknowledgement: CBC and AKN would like to thank Neuromatch Academy https://www.neuromatchacademy.org
  for introducing the authors to each other. We thank Dr. Krešimir Josic (University
  of Houston) , Fabian Baumann (Humboldt University) and Dr. Igor M. Sokolov (Humboldt
  University) for carefully reading the early versions of the manuscript and providing
  constructive feedback. CBC is supported by the German Deutscher Akademischer Austauschdienst
  (DAAD, https://daad.de), the South African National Research Foundation (NRF, https://nrf.ac.za),
  the University of Cape Town (UCT, https://uct.ac.za), and the NOMIS Foundation through
  the NOMIS Fellowships at IST Austria program (https://nomisfoundation.ch). SVV appreciate
  the generosity of Tecnológico de Monterrey for covering the publication fee.
article_number: '9234'
article_processing_charge: No
article_type: original
author:
- first_name: Christopher
  full_name: Currin, Christopher
  id: e8321fc5-3091-11eb-8a53-83f309a11ac9
  last_name: Currin
  orcid: 0000-0002-4809-5059
- first_name: Sebastián Vallejo
  full_name: Vera, Sebastián Vallejo
  last_name: Vera
- first_name: Ali
  full_name: Khaledi-Nasab, Ali
  last_name: Khaledi-Nasab
citation:
  ama: Currin C, Vera SV, Khaledi-Nasab A. Depolarization of echo chambers by random
    dynamical nudge. <i>Scientific Reports</i>. 2022;12. doi:<a href="https://doi.org/10.1038/s41598-022-12494-w">10.1038/s41598-022-12494-w</a>
  apa: Currin, C., Vera, S. V., &#38; Khaledi-Nasab, A. (2022). Depolarization of
    echo chambers by random dynamical nudge. <i>Scientific Reports</i>. Springer Nature.
    <a href="https://doi.org/10.1038/s41598-022-12494-w">https://doi.org/10.1038/s41598-022-12494-w</a>
  chicago: Currin, Christopher, Sebastián Vallejo Vera, and Ali Khaledi-Nasab. “Depolarization
    of Echo Chambers by Random Dynamical Nudge.” <i>Scientific Reports</i>. Springer
    Nature, 2022. <a href="https://doi.org/10.1038/s41598-022-12494-w">https://doi.org/10.1038/s41598-022-12494-w</a>.
  ieee: C. Currin, S. V. Vera, and A. Khaledi-Nasab, “Depolarization of echo chambers
    by random dynamical nudge,” <i>Scientific Reports</i>, vol. 12. Springer Nature,
    2022.
  ista: Currin C, Vera SV, Khaledi-Nasab A. 2022. Depolarization of echo chambers
    by random dynamical nudge. Scientific Reports. 12, 9234.
  mla: Currin, Christopher, et al. “Depolarization of Echo Chambers by Random Dynamical
    Nudge.” <i>Scientific Reports</i>, vol. 12, 9234, Springer Nature, 2022, doi:<a
    href="https://doi.org/10.1038/s41598-022-12494-w">10.1038/s41598-022-12494-w</a>.
  short: C. Currin, S.V. Vera, A. Khaledi-Nasab, Scientific Reports 12 (2022).
date_created: 2023-01-16T09:48:30Z
date_published: 2022-06-02T00:00:00Z
date_updated: 2023-08-04T09:26:30Z
day: '02'
ddc:
- '570'
department:
- _id: TiVo
doi: 10.1038/s41598-022-12494-w
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title: Depolarization of echo chambers by random dynamical nudge
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