---
_id: '14827'
abstract:
- lang: eng
  text: Understanding complex living systems, which are fundamentally constrained
    by physical phenomena, requires combining experimental data with theoretical physical
    and mathematical models. To develop such models, collaborations between experimental
    cell biologists and theoreticians are increasingly important but these two groups
    often face challenges achieving mutual understanding. To help navigate these challenges,
    this Perspective discusses different modelling approaches, including bottom-up
    hypothesis-driven and top-down data-driven models, and highlights their strengths
    and applications. Using cell mechanics as an example, we explore the integration
    of specific physical models with experimental data from the molecular, cellular
    and tissue level up to multiscale input. We also emphasize the importance of constraining
    model complexity and outline strategies for crosstalk between experimental design
    and model development. Furthermore, we highlight how physical models can provide
    conceptual insights and produce unifying and generalizable frameworks for biological
    phenomena. Overall, this Perspective aims to promote fruitful collaborations that
    advance our understanding of complex biological systems.
acknowledgement: "We thank Prisca Liberali and Edouard Hannezo for many inspiring
  discussions; Mehmet Can Uçar, Nicoletta I Petridou and Qiutan Yang for a critical
  reading of the manuscript, and Claudia Flandoli for the artwork in Figs 2 and 3.
  We would also like to thank The Company of Biologists for the opportunity to attend
  the 2023 workshop on Collective Cell Migration, and all workshop participants for
  discussions.\r\nC.S. was supported by a European Molecular Biology Organization
  (EMBO) Postdoctoral Fellowship (ALTF 660-2020) and Human Frontier Science Program
  (HFSP) Postdoctoral fellowship (LT000746/2021-L). D.B.B. was supported by the NOMIS
  Foundation as a NOMIS Fellow and by an EMBO Postdoctoral Fellowship (ALTF 343-2022)."
article_number: jcs.261515
article_processing_charge: No
article_type: original
author:
- first_name: Cornelia
  full_name: Schwayer, Cornelia
  id: 3436488C-F248-11E8-B48F-1D18A9856A87
  last_name: Schwayer
  orcid: 0000-0001-5130-2226
- first_name: David
  full_name: Brückner, David
  id: e1e86031-6537-11eb-953a-f7ab92be508d
  last_name: Brückner
  orcid: 0000-0001-7205-2975
citation:
  ama: Schwayer C, Brückner D. Connecting theory and experiment in cell and tissue
    mechanics. <i>Journal of Cell Science</i>. 2023;136(24). doi:<a href="https://doi.org/10.1242/jcs.261515">10.1242/jcs.261515</a>
  apa: Schwayer, C., &#38; Brückner, D. (2023). Connecting theory and experiment in
    cell and tissue mechanics. <i>Journal of Cell Science</i>. The Company of Biologists.
    <a href="https://doi.org/10.1242/jcs.261515">https://doi.org/10.1242/jcs.261515</a>
  chicago: Schwayer, Cornelia, and David Brückner. “Connecting Theory and Experiment
    in Cell and Tissue Mechanics.” <i>Journal of Cell Science</i>. The Company of
    Biologists, 2023. <a href="https://doi.org/10.1242/jcs.261515">https://doi.org/10.1242/jcs.261515</a>.
  ieee: C. Schwayer and D. Brückner, “Connecting theory and experiment in cell and
    tissue mechanics,” <i>Journal of Cell Science</i>, vol. 136, no. 24. The Company
    of Biologists, 2023.
  ista: Schwayer C, Brückner D. 2023. Connecting theory and experiment in cell and
    tissue mechanics. Journal of Cell Science. 136(24), jcs. 261515.
  mla: Schwayer, Cornelia, and David Brückner. “Connecting Theory and Experiment in
    Cell and Tissue Mechanics.” <i>Journal of Cell Science</i>, vol. 136, no. 24,
    jcs. 261515, The Company of Biologists, 2023, doi:<a href="https://doi.org/10.1242/jcs.261515">10.1242/jcs.261515</a>.
  short: C. Schwayer, D. Brückner, Journal of Cell Science 136 (2023).
date_created: 2024-01-17T12:46:55Z
date_published: 2023-12-27T00:00:00Z
date_updated: 2024-01-22T13:35:48Z
day: '27'
department:
- _id: EdHa
- _id: CaHe
doi: 10.1242/jcs.261515
external_id:
  pmid:
  - '38149871'
intvolume: '       136'
issue: '24'
keyword:
- Cell Biology
language:
- iso: eng
month: '12'
oa_version: None
pmid: 1
project:
- _id: 34e2a5b5-11ca-11ed-8bc3-b2265616ef0b
  grant_number: 343-2022
  name: A mechano-chemical theory for stem cell fate decisions in organoid development
publication: Journal of Cell Science
publication_identifier:
  eissn:
  - 1477-9137
  issn:
  - 0021-9533
publication_status: published
publisher: The Company of Biologists
quality_controlled: '1'
scopus_import: '1'
status: public
title: Connecting theory and experiment in cell and tissue mechanics
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 136
year: '2023'
...
---
_id: '13261'
abstract:
- lang: eng
  text: Chromosomes in the eukaryotic nucleus are highly compacted. However, for many
    functional processes, including transcription initiation, the pairwise motion
    of distal chromosomal elements such as enhancers and promoters is essential and
    necessitates dynamic fluidity. Here, we used a live-imaging assay to simultaneously
    measure the positions of pairs of enhancers and promoters and their transcriptional
    output while systematically varying the genomic separation between these two DNA
    loci. Our analysis reveals the coexistence of a compact globular organization
    and fast subdiffusive dynamics. These combined features cause an anomalous scaling
    of polymer relaxation times with genomic separation leading to long-ranged correlations.
    Thus, encounter times of DNA loci are much less dependent on genomic distance
    than predicted by existing polymer models, with potential consequences for eukaryotic
    gene expression.
acknowledgement: This work was supported in part by the U.S. National Science Foundation,
  the Center for the Physics of Biological Function (grant PHY-1734030), and the National
  Institutes of Health (grants R01GM097275, U01DA047730, and U01DK127429). D.B.B.
  was supported by the NOMIS Foundation as a fellow and by an EMBO postdoctoral fellowship
  (ALTF 343-2022). H.C. was supported by a Charles H. Revson Biomedical Science Fellowship.
article_processing_charge: No
article_type: original
author:
- first_name: David
  full_name: Brückner, David
  id: e1e86031-6537-11eb-953a-f7ab92be508d
  last_name: Brückner
  orcid: 0000-0001-7205-2975
- first_name: Hongtao
  full_name: Chen, Hongtao
  last_name: Chen
- first_name: Lev
  full_name: Barinov, Lev
  last_name: Barinov
- first_name: Benjamin
  full_name: Zoller, Benjamin
  last_name: Zoller
- first_name: Thomas
  full_name: Gregor, Thomas
  last_name: Gregor
citation:
  ama: Brückner D, Chen H, Barinov L, Zoller B, Gregor T. Stochastic motion and transcriptional
    dynamics of pairs of distal DNA loci on a compacted chromosome. <i>Science</i>.
    2023;380(6652):1357-1362. doi:<a href="https://doi.org/10.1126/science.adf5568">10.1126/science.adf5568</a>
  apa: Brückner, D., Chen, H., Barinov, L., Zoller, B., &#38; Gregor, T. (2023). Stochastic
    motion and transcriptional dynamics of pairs of distal DNA loci on a compacted
    chromosome. <i>Science</i>. American Association for the Advancement of Science.
    <a href="https://doi.org/10.1126/science.adf5568">https://doi.org/10.1126/science.adf5568</a>
  chicago: Brückner, David, Hongtao Chen, Lev Barinov, Benjamin Zoller, and Thomas
    Gregor. “Stochastic Motion and Transcriptional Dynamics of Pairs of Distal DNA
    Loci on a Compacted Chromosome.” <i>Science</i>. American Association for the
    Advancement of Science, 2023. <a href="https://doi.org/10.1126/science.adf5568">https://doi.org/10.1126/science.adf5568</a>.
  ieee: D. Brückner, H. Chen, L. Barinov, B. Zoller, and T. Gregor, “Stochastic motion
    and transcriptional dynamics of pairs of distal DNA loci on a compacted chromosome,”
    <i>Science</i>, vol. 380, no. 6652. American Association for the Advancement of
    Science, pp. 1357–1362, 2023.
  ista: Brückner D, Chen H, Barinov L, Zoller B, Gregor T. 2023. Stochastic motion
    and transcriptional dynamics of pairs of distal DNA loci on a compacted chromosome.
    Science. 380(6652), 1357–1362.
  mla: Brückner, David, et al. “Stochastic Motion and Transcriptional Dynamics of
    Pairs of Distal DNA Loci on a Compacted Chromosome.” <i>Science</i>, vol. 380,
    no. 6652, American Association for the Advancement of Science, 2023, pp. 1357–62,
    doi:<a href="https://doi.org/10.1126/science.adf5568">10.1126/science.adf5568</a>.
  short: D. Brückner, H. Chen, L. Barinov, B. Zoller, T. Gregor, Science 380 (2023)
    1357–1362.
date_created: 2023-07-23T22:01:12Z
date_published: 2023-06-29T00:00:00Z
date_updated: 2023-12-13T11:41:07Z
day: '29'
department:
- _id: EdHa
doi: 10.1126/science.adf5568
external_id:
  isi:
  - '001106405600028'
intvolume: '       380'
isi: 1
issue: '6652'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://doi.org/10.1126/science.adf5568
month: '06'
oa: 1
oa_version: Preprint
page: 1357-1362
project:
- _id: 34e2a5b5-11ca-11ed-8bc3-b2265616ef0b
  grant_number: 343-2022
  name: A mechano-chemical theory for stem cell fate decisions in organoid development
publication: Science
publication_identifier:
  eissn:
  - 1095-9203
publication_status: published
publisher: American Association for the Advancement of Science
quality_controlled: '1'
scopus_import: '1'
status: public
title: Stochastic motion and transcriptional dynamics of pairs of distal DNA loci
  on a compacted chromosome
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 380
year: '2023'
...
---
_id: '12818'
abstract:
- lang: eng
  text: The multicellular organization of diverse systems, including embryos, intestines,
    and tumors relies on coordinated cell migration in curved environments. In these
    settings, cells establish supracellular patterns of motion, including collective
    rotation and invasion. While such collective modes have been studied extensively
    in flat systems, the consequences of geometrical and topological constraints on
    collective migration in curved systems are largely unknown. Here, we discover
    a collective mode of cell migration in rotating spherical tissues manifesting
    as a propagating single-wavelength velocity wave. This wave is accompanied by
    an apparently incompressible supracellular flow pattern featuring topological
    defects as dictated by the spherical topology. Using a minimal active particle
    model, we reveal that this collective mode arises from the effect of curvature
    on the active flocking behavior of a cell layer confined to a spherical surface.
    Our results thus identify curvature-induced velocity waves as a mode of collective
    cell migration, impacting the dynamical organization of 3D curved tissues.
acknowledgement: We thank H. Abbaszadeh, M.J. Bowick, G. Gradziuk, M.C. Marchetti,
  and S. Shankar for their helpful discussions. Funded by the Deutsche Forschungsgemeinschaft
  (DFG, German Research Foundation)—Project-ID 201269156-SFB 1032 (Project B12). D.B.B.
  is a NOMIS fellow supported by the NOMIS foundation and was in part supported by
  a DFG fellowship within the Graduate School of Quantitative Biosciences Munich (QBM)
  and Joachim Herz Stiftung. R.A. acknowledges support from the Human Frontier Science
  Program (LT000475/2018-C) and from the National Science Foundation, through the
  Center for the Physics of Biological Function (PHY-1734030). M.G. acknowledges support
  from NIH R01GM140108 and Alfred Sloan Foundation. Funded by the Deutsche Forschungsgemeinschaft
  (DFG, German Research Foundation)—Project-ID 201269156-SFB 1032 (Project B12).Open
  Access funding enabled and organized by Projekt DEAL.
article_number: '1643'
article_processing_charge: No
article_type: original
author:
- first_name: Tom
  full_name: Brandstätter, Tom
  last_name: Brandstätter
- first_name: David
  full_name: Brückner, David
  id: e1e86031-6537-11eb-953a-f7ab92be508d
  last_name: Brückner
  orcid: 0000-0001-7205-2975
- first_name: Yu Long
  full_name: Han, Yu Long
  last_name: Han
- first_name: Ricard
  full_name: Alert, Ricard
  last_name: Alert
- first_name: Ming
  full_name: Guo, Ming
  last_name: Guo
- first_name: Chase P.
  full_name: Broedersz, Chase P.
  last_name: Broedersz
citation:
  ama: Brandstätter T, Brückner D, Han YL, Alert R, Guo M, Broedersz CP. Curvature
    induces active velocity waves in rotating spherical tissues. <i>Nature Communications</i>.
    2023;14. doi:<a href="https://doi.org/10.1038/s41467-023-37054-2">10.1038/s41467-023-37054-2</a>
  apa: Brandstätter, T., Brückner, D., Han, Y. L., Alert, R., Guo, M., &#38; Broedersz,
    C. P. (2023). Curvature induces active velocity waves in rotating spherical tissues.
    <i>Nature Communications</i>. Springer Nature. <a href="https://doi.org/10.1038/s41467-023-37054-2">https://doi.org/10.1038/s41467-023-37054-2</a>
  chicago: Brandstätter, Tom, David Brückner, Yu Long Han, Ricard Alert, Ming Guo,
    and Chase P. Broedersz. “Curvature Induces Active Velocity Waves in Rotating Spherical
    Tissues.” <i>Nature Communications</i>. Springer Nature, 2023. <a href="https://doi.org/10.1038/s41467-023-37054-2">https://doi.org/10.1038/s41467-023-37054-2</a>.
  ieee: T. Brandstätter, D. Brückner, Y. L. Han, R. Alert, M. Guo, and C. P. Broedersz,
    “Curvature induces active velocity waves in rotating spherical tissues,” <i>Nature
    Communications</i>, vol. 14. Springer Nature, 2023.
  ista: Brandstätter T, Brückner D, Han YL, Alert R, Guo M, Broedersz CP. 2023. Curvature
    induces active velocity waves in rotating spherical tissues. Nature Communications.
    14, 1643.
  mla: Brandstätter, Tom, et al. “Curvature Induces Active Velocity Waves in Rotating
    Spherical Tissues.” <i>Nature Communications</i>, vol. 14, 1643, Springer Nature,
    2023, doi:<a href="https://doi.org/10.1038/s41467-023-37054-2">10.1038/s41467-023-37054-2</a>.
  short: T. Brandstätter, D. Brückner, Y.L. Han, R. Alert, M. Guo, C.P. Broedersz,
    Nature Communications 14 (2023).
date_created: 2023-04-09T22:01:00Z
date_published: 2023-03-24T00:00:00Z
date_updated: 2023-08-01T14:05:30Z
day: '24'
ddc:
- '570'
department:
- _id: EdHa
doi: 10.1038/s41467-023-37054-2
external_id:
  isi:
  - '000959887700008'
  pmid:
  - '36964141'
file:
- access_level: open_access
  checksum: 54f06f9eee11d43bab253f3492c983ba
  content_type: application/pdf
  creator: dernst
  date_created: 2023-04-11T06:27:00Z
  date_updated: 2023-04-11T06:27:00Z
  file_id: '12821'
  file_name: 2023_NatureComm_Brandstaetter.pdf
  file_size: 4146777
  relation: main_file
  success: 1
file_date_updated: 2023-04-11T06:27:00Z
has_accepted_license: '1'
intvolume: '        14'
isi: 1
language:
- iso: eng
license: https://creativecommons.org/licenses/by/4.0/
month: '03'
oa: 1
oa_version: Published Version
pmid: 1
publication: Nature Communications
publication_identifier:
  eissn:
  - 2041-1723
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: Curvature induces active velocity waves in rotating spherical tissues
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 14
year: '2023'
...
---
_id: '10530'
abstract:
- lang: eng
  text: "Cell dispersion from a confined area is fundamental in a number of biological
    processes,\r\nincluding cancer metastasis. To date, a quantitative understanding
    of the interplay of single\r\ncell motility, cell proliferation, and intercellular
    contacts remains elusive. In particular, the role\r\nof E- and N-Cadherin junctions,
    central components of intercellular contacts, is still\r\ncontroversial. Combining
    theoretical modeling with in vitro observations, we investigate the\r\ncollective
    spreading behavior of colonies of human cancer cells (T24). The spreading of these\r\ncolonies
    is driven by stochastic single-cell migration with frequent transient cell-cell
    contacts.\r\nWe find that inhibition of E- and N-Cadherin junctions decreases
    colony spreading and average\r\nspreading velocities, without affecting the strength
    of correlations in spreading velocities of\r\nneighboring cells. Based on a biophysical
    simulation model for cell migration, we show that the\r\nbehavioral changes upon
    disruption of these junctions can be explained by reduced repulsive\r\nexcluded
    volume interactions between cells. This suggests that in cancer cell migration,\r\ncadherin-based
    intercellular contacts sharpen cell boundaries leading to repulsive rather than\r\ncohesive
    interactions between cells, thereby promoting efficient cell spreading during
    collective\r\nmigration.\r\n"
acknowledgement: Funded by the Deutsche Forschungsgemeinschaft (DFG, German Research
  Foundation) - Project-ID 201269156 - SFB 1032 (Projects B8 and B12). D.B.B. is supported
  in part by a DFG fellowship within the Graduate School of Quantitative Biosciences
  Munich (QBM) and by the Joachim Herz Stiftung.
article_processing_charge: No
article_type: original
author:
- first_name: Themistoklis
  full_name: Zisis, Themistoklis
  last_name: Zisis
- first_name: David
  full_name: Brückner, David
  id: e1e86031-6537-11eb-953a-f7ab92be508d
  last_name: Brückner
  orcid: 0000-0001-7205-2975
- first_name: Tom
  full_name: Brandstätter, Tom
  last_name: Brandstätter
- first_name: Wei Xiong
  full_name: Siow, Wei Xiong
  last_name: Siow
- first_name: Joseph
  full_name: d’Alessandro, Joseph
  last_name: d’Alessandro
- first_name: Angelika M.
  full_name: Vollmar, Angelika M.
  last_name: Vollmar
- first_name: Chase P.
  full_name: Broedersz, Chase P.
  last_name: Broedersz
- first_name: Stefan
  full_name: Zahler, Stefan
  last_name: Zahler
citation:
  ama: Zisis T, Brückner D, Brandstätter T, et al. Disentangling cadherin-mediated
    cell-cell interactions in collective cancer cell migration. <i>Biophysical Journal</i>.
    2022;121(1):P44-60. doi:<a href="https://doi.org/10.1016/j.bpj.2021.12.006">10.1016/j.bpj.2021.12.006</a>
  apa: Zisis, T., Brückner, D., Brandstätter, T., Siow, W. X., d’Alessandro, J., Vollmar,
    A. M., … Zahler, S. (2022). Disentangling cadherin-mediated cell-cell interactions
    in collective cancer cell migration. <i>Biophysical Journal</i>. Elsevier. <a
    href="https://doi.org/10.1016/j.bpj.2021.12.006">https://doi.org/10.1016/j.bpj.2021.12.006</a>
  chicago: Zisis, Themistoklis, David Brückner, Tom Brandstätter, Wei Xiong Siow,
    Joseph d’Alessandro, Angelika M. Vollmar, Chase P. Broedersz, and Stefan Zahler.
    “Disentangling Cadherin-Mediated Cell-Cell Interactions in Collective Cancer Cell
    Migration.” <i>Biophysical Journal</i>. Elsevier, 2022. <a href="https://doi.org/10.1016/j.bpj.2021.12.006">https://doi.org/10.1016/j.bpj.2021.12.006</a>.
  ieee: T. Zisis <i>et al.</i>, “Disentangling cadherin-mediated cell-cell interactions
    in collective cancer cell migration,” <i>Biophysical Journal</i>, vol. 121, no.
    1. Elsevier, pp. P44-60, 2022.
  ista: Zisis T, Brückner D, Brandstätter T, Siow WX, d’Alessandro J, Vollmar AM,
    Broedersz CP, Zahler S. 2022. Disentangling cadherin-mediated cell-cell interactions
    in collective cancer cell migration. Biophysical Journal. 121(1), P44-60.
  mla: Zisis, Themistoklis, et al. “Disentangling Cadherin-Mediated Cell-Cell Interactions
    in Collective Cancer Cell Migration.” <i>Biophysical Journal</i>, vol. 121, no.
    1, Elsevier, 2022, pp. P44-60, doi:<a href="https://doi.org/10.1016/j.bpj.2021.12.006">10.1016/j.bpj.2021.12.006</a>.
  short: T. Zisis, D. Brückner, T. Brandstätter, W.X. Siow, J. d’Alessandro, A.M.
    Vollmar, C.P. Broedersz, S. Zahler, Biophysical Journal 121 (2022) P44-60.
date_created: 2021-12-10T09:48:19Z
date_published: 2022-01-04T00:00:00Z
date_updated: 2023-08-02T13:34:25Z
day: '04'
ddc:
- '570'
department:
- _id: EdHa
- _id: GaTk
doi: 10.1016/j.bpj.2021.12.006
external_id:
  isi:
  - '000740815400007'
file:
- access_level: open_access
  checksum: 1aa7c3478e0c8256b973b632efd1f6b4
  content_type: application/pdf
  creator: dernst
  date_created: 2022-07-29T10:17:10Z
  date_updated: 2022-07-29T10:17:10Z
  file_id: '11697'
  file_name: 2022_BiophysicalJour_Zisis.pdf
  file_size: 4475504
  relation: main_file
  success: 1
file_date_updated: 2022-07-29T10:17:10Z
has_accepted_license: '1'
intvolume: '       121'
isi: 1
issue: '1'
keyword:
- Biophysics
language:
- iso: eng
license: https://creativecommons.org/licenses/by-nc-nd/4.0/
month: '01'
oa: 1
oa_version: Published Version
page: P44-60
project:
- _id: 9B861AAC-BA93-11EA-9121-9846C619BF3A
  name: NOMIS Fellowship Program
publication: Biophysical Journal
publication_identifier:
  issn:
  - 0006-3495
publication_status: published
publisher: Elsevier
quality_controlled: '1'
status: public
title: Disentangling cadherin-mediated cell-cell interactions in collective cancer
  cell migration
tmp:
  image: /images/cc_by_nc_nd.png
  legal_code_url: https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode
  name: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
    (CC BY-NC-ND 4.0)
  short: CC BY-NC-ND (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 121
year: '2022'
...
---
_id: '12277'
abstract:
- lang: eng
  text: Cell migration in confining physiological environments relies on the concerted
    dynamics of several cellular components, including protrusions, adhesions with
    the environment, and the cell nucleus. However, it remains poorly understood how
    the dynamic interplay of these components and the cell polarity determine the
    emergent migration behavior at the cellular scale. Here, we combine data-driven
    inference with a mechanistic bottom-up approach to develop a model for protrusion
    and polarity dynamics in confined cell migration, revealing how the cellular dynamics
    adapt to confining geometries. Specifically, we use experimental data of joint
    protrusion-nucleus migration trajectories of cells on confining micropatterns
    to systematically determine a mechanistic model linking the stochastic dynamics
    of cell polarity, protrusions, and nucleus. This model indicates that the cellular
    dynamics adapt to confining constrictions through a switch in the polarity dynamics
    from a negative to a positive self-reinforcing feedback loop. Our model further
    reveals how this feedback loop leads to stereotypical cycles of protrusion-nucleus
    dynamics that drive the migration of the cell through constrictions. These cycles
    are disrupted upon perturbation of cytoskeletal components, indicating that the
    positive feedback is controlled by cellular migration mechanisms. Our data-driven
    theoretical approach therefore identifies polarity feedback adaptation as a key
    mechanism in confined cell migration.
acknowledgement: "We thank Grzegorz Gradziuk, StevenRiedijk, Janni Harju, and M. R.
  Schnucki for helpful discussions, and Andriy Goychuk for advice on the image segmentation.
  This project\r\nwas funded by the Deutsche Forschungsgemeinschaft (DFG, German Research
  Foundation), Project No. 201269156—SFB 1032 (Projects B01 and B12). D. B. B. is
  supported by the NOMIS Foundation and in part by a DFG fellowship within the Graduate
  School of Quantitative Biosciences Munich (QBM), as well as by the Joachim Herz
  Stiftung."
article_number: '031041'
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: David
  full_name: Brückner, David
  id: e1e86031-6537-11eb-953a-f7ab92be508d
  last_name: Brückner
  orcid: 0000-0001-7205-2975
- first_name: Matthew
  full_name: Schmitt, Matthew
  last_name: Schmitt
- first_name: Alexandra
  full_name: Fink, Alexandra
  last_name: Fink
- first_name: Georg
  full_name: Ladurner, Georg
  last_name: Ladurner
- first_name: Johannes
  full_name: Flommersfeld, Johannes
  last_name: Flommersfeld
- first_name: Nicolas
  full_name: Arlt, Nicolas
  last_name: Arlt
- first_name: Edouard B
  full_name: Hannezo, Edouard B
  id: 3A9DB764-F248-11E8-B48F-1D18A9856A87
  last_name: Hannezo
  orcid: 0000-0001-6005-1561
- first_name: Joachim O.
  full_name: Rädler, Joachim O.
  last_name: Rädler
- first_name: Chase P.
  full_name: Broedersz, Chase P.
  last_name: Broedersz
citation:
  ama: Brückner D, Schmitt M, Fink A, et al. Geometry adaptation of protrusion and
    polarity dynamics in confined cell migration. <i>Physical Review X</i>. 2022;12(3).
    doi:<a href="https://doi.org/10.1103/physrevx.12.031041">10.1103/physrevx.12.031041</a>
  apa: Brückner, D., Schmitt, M., Fink, A., Ladurner, G., Flommersfeld, J., Arlt,
    N., … Broedersz, C. P. (2022). Geometry adaptation of protrusion and polarity
    dynamics in confined cell migration. <i>Physical Review X</i>. American Physical
    Society. <a href="https://doi.org/10.1103/physrevx.12.031041">https://doi.org/10.1103/physrevx.12.031041</a>
  chicago: Brückner, David, Matthew Schmitt, Alexandra Fink, Georg Ladurner, Johannes
    Flommersfeld, Nicolas Arlt, Edouard B Hannezo, Joachim O. Rädler, and Chase P.
    Broedersz. “Geometry Adaptation of Protrusion and Polarity Dynamics in Confined
    Cell Migration.” <i>Physical Review X</i>. American Physical Society, 2022. <a
    href="https://doi.org/10.1103/physrevx.12.031041">https://doi.org/10.1103/physrevx.12.031041</a>.
  ieee: D. Brückner <i>et al.</i>, “Geometry adaptation of protrusion and polarity
    dynamics in confined cell migration,” <i>Physical Review X</i>, vol. 12, no. 3.
    American Physical Society, 2022.
  ista: Brückner D, Schmitt M, Fink A, Ladurner G, Flommersfeld J, Arlt N, Hannezo
    EB, Rädler JO, Broedersz CP. 2022. Geometry adaptation of protrusion and polarity
    dynamics in confined cell migration. Physical Review X. 12(3), 031041.
  mla: Brückner, David, et al. “Geometry Adaptation of Protrusion and Polarity Dynamics
    in Confined Cell Migration.” <i>Physical Review X</i>, vol. 12, no. 3, 031041,
    American Physical Society, 2022, doi:<a href="https://doi.org/10.1103/physrevx.12.031041">10.1103/physrevx.12.031041</a>.
  short: D. Brückner, M. Schmitt, A. Fink, G. Ladurner, J. Flommersfeld, N. Arlt,
    E.B. Hannezo, J.O. Rädler, C.P. Broedersz, Physical Review X 12 (2022).
date_created: 2023-01-16T10:02:06Z
date_published: 2022-09-20T00:00:00Z
date_updated: 2023-08-04T10:25:49Z
day: '20'
ddc:
- '530'
- '570'
department:
- _id: EdHa
doi: 10.1103/physrevx.12.031041
external_id:
  arxiv:
  - '2106.01014'
  isi:
  - '000861534700001'
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intvolume: '        12'
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keyword:
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language:
- iso: eng
month: '09'
oa: 1
oa_version: Published Version
publication: Physical Review X
publication_identifier:
  issn:
  - 2160-3308
publication_status: published
publisher: American Physical Society
quality_controlled: '1'
scopus_import: '1'
status: public
title: Geometry adaptation of protrusion and polarity dynamics in confined cell migration
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type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 12
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...