---
_id: '7957'
abstract:
- lang: eng
  text: "Neurodevelopmental disorders (NDDs) are a class of disorders affecting brain
    development and function and are characterized by wide genetic and clinical variability.
    In this review, we discuss the multiple factors that influence the clinical presentation
    of NDDs, with particular attention to gene vulnerability, mutational load, and
    the two-hit model. Despite the complex architecture of\r\nmutational events associated
    with NDDs, the various proteins involved appear to converge on common pathways,
    such as synaptic plasticity/function, chromatin remodelers and the mammalian target
    of rapamycin (mTOR) pathway. A thorough understanding of the mechanisms behind
    these pathways will hopefully lead to the identification of candidates that could
    be targeted for treatment approaches."
acknowledgement: We wish to thank Jasmin Morandell for generously sharing Figure 2.
  This work was supported by the European Research Council Starting Grant (grant 715508
  ) to G.N.
article_processing_charge: No
article_type: original
author:
- first_name: Ilaria
  full_name: Parenti, Ilaria
  id: D93538B0-5B71-11E9-AC62-02EBE5697425
  last_name: Parenti
- first_name: Luis E
  full_name: Garcia Rabaneda, Luis E
  id: 33D1B084-F248-11E8-B48F-1D18A9856A87
  last_name: Garcia Rabaneda
- first_name: Hanna
  full_name: Schön, Hanna
  id: C8E17EDC-D7AA-11E9-B7B7-45ECE5697425
  last_name: Schön
- first_name: Gaia
  full_name: Novarino, Gaia
  id: 3E57A680-F248-11E8-B48F-1D18A9856A87
  last_name: Novarino
  orcid: 0000-0002-7673-7178
citation:
  ama: 'Parenti I, Garcia Rabaneda LE, Schön H, Novarino G. Neurodevelopmental disorders:
    From genetics to functional pathways. <i>Trends in Neurosciences</i>. 2020;43(8):608-621.
    doi:<a href="https://doi.org/10.1016/j.tins.2020.05.004">10.1016/j.tins.2020.05.004</a>'
  apa: 'Parenti, I., Garcia Rabaneda, L. E., Schön, H., &#38; Novarino, G. (2020).
    Neurodevelopmental disorders: From genetics to functional pathways. <i>Trends
    in Neurosciences</i>. Elsevier. <a href="https://doi.org/10.1016/j.tins.2020.05.004">https://doi.org/10.1016/j.tins.2020.05.004</a>'
  chicago: 'Parenti, Ilaria, Luis E Garcia Rabaneda, Hanna Schön, and Gaia Novarino.
    “Neurodevelopmental Disorders: From Genetics to Functional Pathways.” <i>Trends
    in Neurosciences</i>. Elsevier, 2020. <a href="https://doi.org/10.1016/j.tins.2020.05.004">https://doi.org/10.1016/j.tins.2020.05.004</a>.'
  ieee: 'I. Parenti, L. E. Garcia Rabaneda, H. Schön, and G. Novarino, “Neurodevelopmental
    disorders: From genetics to functional pathways,” <i>Trends in Neurosciences</i>,
    vol. 43, no. 8. Elsevier, pp. 608–621, 2020.'
  ista: 'Parenti I, Garcia Rabaneda LE, Schön H, Novarino G. 2020. Neurodevelopmental
    disorders: From genetics to functional pathways. Trends in Neurosciences. 43(8),
    608–621.'
  mla: 'Parenti, Ilaria, et al. “Neurodevelopmental Disorders: From Genetics to Functional
    Pathways.” <i>Trends in Neurosciences</i>, vol. 43, no. 8, Elsevier, 2020, pp.
    608–21, doi:<a href="https://doi.org/10.1016/j.tins.2020.05.004">10.1016/j.tins.2020.05.004</a>.'
  short: I. Parenti, L.E. Garcia Rabaneda, H. Schön, G. Novarino, Trends in Neurosciences
    43 (2020) 608–621.
date_created: 2020-06-14T22:00:49Z
date_published: 2020-08-01T00:00:00Z
date_updated: 2023-08-21T08:25:31Z
day: '01'
ddc:
- '570'
department:
- _id: GaNo
doi: 10.1016/j.tins.2020.05.004
ec_funded: 1
external_id:
  isi:
  - '000553090600008'
  pmid:
  - '32507511'
file:
- access_level: open_access
  checksum: 67db0251b1d415ae59005f876fcf9e34
  content_type: application/pdf
  creator: dernst
  date_created: 2020-11-25T09:43:40Z
  date_updated: 2020-11-25T09:43:40Z
  file_id: '8805'
  file_name: 2020_TrendsNeuroscience_Parenti.pdf
  file_size: 1439550
  relation: main_file
  success: 1
file_date_updated: 2020-11-25T09:43:40Z
has_accepted_license: '1'
intvolume: '        43'
isi: 1
issue: '8'
language:
- iso: eng
month: '08'
oa: 1
oa_version: Published Version
page: 608-621
pmid: 1
project:
- _id: 25444568-B435-11E9-9278-68D0E5697425
  call_identifier: H2020
  grant_number: '715508'
  name: Probing the Reversibility of Autism Spectrum Disorders by Employing in vivo
    and in vitro Models
publication: Trends in Neurosciences
publication_identifier:
  eissn:
  - 1878108X
  issn:
  - '01662236'
publication_status: published
publisher: Elsevier
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Neurodevelopmental disorders: From genetics to functional pathways'
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 43
year: '2020'
...