---
_id: '12531'
abstract:
- lang: eng
  text: "All visual experiences of the vertebrates begin with light being converted
    into electrical signals\r\nby the eye retina. Retinal ganglion cells (RGCs) are
    the neurons of the innermost layer of the\r\nmammal retina, and they transmit
    visual information to the rest of the brain.\r\nIt has been shown that RGCs vary
    in their morphology and genetic profiles, moreover they can\r\nbe unambiguously
    grouped into subtypes that share the same morphological and/or molecular\r\nproperties.
    However, in terms of RGCs function, it remains unclear how many distinct types\r\nthere
    are and what response properties their typology relies on. Even given the recent
    studies\r\nthat successfully classified RGCs in a patch of the retina [1] and
    in scotopic conditions [2], the\r\nquestion remains whether the found subtypes
    persist across the entire retina.\r\nIn this work, using a novel imaging method,
    we show that, when sampled from a large portion\r\nof the retina, RGCs can not
    be clearly divided into functional subtypes. We found that in\r\nphotopic conditions,
    which implies more prominent natural scene statistic differences across\r\nthe
    visual field, response properties can be exhibited by cells differently depending
    on their\r\nlocation in the retina, which leads to formation of a gradient of
    features rather than distinct\r\nclasses.\r\nThis finding suggests that RGCs follow
    a global organization across the visual field of the\r\nanimal, adapting each
    RGC subtype to the requirements imposed by the natural scene statistics."
alternative_title:
- ISTA Master's Thesis
article_processing_charge: No
author:
- first_name: Kseniia
  full_name: Kirillova, Kseniia
  id: 8e3f931e-dc85-11ea-9058-e7b957bf23f0
  last_name: Kirillova
citation:
  ama: Kirillova K. Panoramic functional gradients across the mouse retina. 2023.
    doi:<a href="https://doi.org/10.15479/at:ista:12531">10.15479/at:ista:12531</a>
  apa: Kirillova, K. (2023). <i>Panoramic functional gradients across the mouse retina</i>.
    Institute of Science and Technology Austria. <a href="https://doi.org/10.15479/at:ista:12531">https://doi.org/10.15479/at:ista:12531</a>
  chicago: Kirillova, Kseniia. “Panoramic Functional Gradients across the Mouse Retina.”
    Institute of Science and Technology Austria, 2023. <a href="https://doi.org/10.15479/at:ista:12531">https://doi.org/10.15479/at:ista:12531</a>.
  ieee: K. Kirillova, “Panoramic functional gradients across the mouse retina,” Institute
    of Science and Technology Austria, 2023.
  ista: Kirillova K. 2023. Panoramic functional gradients across the mouse retina.
    Institute of Science and Technology Austria.
  mla: Kirillova, Kseniia. <i>Panoramic Functional Gradients across the Mouse Retina</i>.
    Institute of Science and Technology Austria, 2023, doi:<a href="https://doi.org/10.15479/at:ista:12531">10.15479/at:ista:12531</a>.
  short: K. Kirillova, Panoramic Functional Gradients across the Mouse Retina, Institute
    of Science and Technology Austria, 2023.
date_created: 2023-02-09T07:45:05Z
date_published: 2023-02-08T00:00:00Z
date_updated: 2024-02-09T23:30:04Z
day: '08'
ddc:
- '570'
degree_awarded: MS
department:
- _id: GradSch
- _id: MaJö
doi: 10.15479/at:ista:12531
file:
- access_level: open_access
  checksum: 57d8da3a6c749eb1556b7435fe266a5f
  content_type: application/pdf
  creator: cchlebak
  date_created: 2023-02-09T08:03:32Z
  date_updated: 2024-02-09T23:30:03Z
  embargo: 2024-02-08
  file_id: '12532'
  file_name: Thesis_Kseniia___ISTA__istaustriathesis_PDF-A.pdf
  file_size: 8369317
  relation: main_file
- access_level: closed
  checksum: 87fb44318e4f9eb9da2ad9ad6ca8e76f
  content_type: application/x-zip-compressed
  creator: cchlebak
  date_created: 2023-02-10T09:32:06Z
  date_updated: 2024-02-09T23:30:03Z
  embargo_to: open_access
  file_id: '12535'
  file_name: Thesis Kseniia - ISTA [istaustriathesis]-FINAL.zip
  file_size: 11204408
  relation: source_file
file_date_updated: 2024-02-09T23:30:03Z
has_accepted_license: '1'
language:
- iso: eng
month: '02'
oa: 1
oa_version: Published Version
page: '46'
publication_identifier:
  issn:
  - 2791-4585
publication_status: published
publisher: Institute of Science and Technology Austria
status: public
supervisor:
- first_name: Maximilian A
  full_name: Jösch, Maximilian A
  id: 2BD278E6-F248-11E8-B48F-1D18A9856A87
  last_name: Jösch
  orcid: 0000-0002-3937-1330
title: Panoramic functional gradients across the mouse retina
tmp:
  image: /images/cc_by_nc_sa.png
  legal_code_url: https://creativecommons.org/licenses/by-nc-sa/4.0/legalcode
  name: Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC
    BY-NC-SA 4.0)
  short: CC BY-NC-SA (4.0)
type: dissertation
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
year: '2023'
...