---
_id: '14862'
article_number: ckad160.597
article_processing_charge: No
author:
- first_name: Simon
  full_name: Rella, Simon
  id: B4765ACA-AA38-11E9-AC9A-0930E6697425
  last_name: Rella
- first_name: Y
  full_name: Kulikova, Y
  last_name: Kulikova
- first_name: Aygul
  full_name: Minnegalieva, Aygul
  id: 87DF77F0-1D9A-11EA-B6AE-CE443DDC885E
  last_name: Minnegalieva
- first_name: Fyodor
  full_name: Kondrashov, Fyodor
  id: 44FDEF62-F248-11E8-B48F-1D18A9856A87
  last_name: Kondrashov
  orcid: 0000-0001-8243-4694
citation:
  ama: 'Rella S, Kulikova Y, Minnegalieva A, Kondrashov F. Complex vaccination strategies
    prevent the emergence of vaccine resistance. In: <i>European Journal of Public
    Health</i>. Vol 33. Oxford University Press; 2023. doi:<a href="https://doi.org/10.1093/eurpub/ckad160.597">10.1093/eurpub/ckad160.597</a>'
  apa: Rella, S., Kulikova, Y., Minnegalieva, A., &#38; Kondrashov, F. (2023). Complex
    vaccination strategies prevent the emergence of vaccine resistance. In <i>European
    Journal of Public Health</i> (Vol. 33). Oxford University Press. <a href="https://doi.org/10.1093/eurpub/ckad160.597">https://doi.org/10.1093/eurpub/ckad160.597</a>
  chicago: Rella, Simon, Y Kulikova, Aygul Minnegalieva, and Fyodor Kondrashov. “Complex
    Vaccination Strategies Prevent the Emergence of Vaccine Resistance.” In <i>European
    Journal of Public Health</i>, Vol. 33. Oxford University Press, 2023. <a href="https://doi.org/10.1093/eurpub/ckad160.597">https://doi.org/10.1093/eurpub/ckad160.597</a>.
  ieee: S. Rella, Y. Kulikova, A. Minnegalieva, and F. Kondrashov, “Complex vaccination
    strategies prevent the emergence of vaccine resistance,” in <i>European Journal
    of Public Health</i>, 2023, vol. 33, no. Supplement_2.
  ista: Rella S, Kulikova Y, Minnegalieva A, Kondrashov F. 2023. Complex vaccination
    strategies prevent the emergence of vaccine resistance. European Journal of Public
    Health. vol. 33, ckad160.597.
  mla: Rella, Simon, et al. “Complex Vaccination Strategies Prevent the Emergence
    of Vaccine Resistance.” <i>European Journal of Public Health</i>, vol. 33, no.
    Supplement_2, ckad160.597, Oxford University Press, 2023, doi:<a href="https://doi.org/10.1093/eurpub/ckad160.597">10.1093/eurpub/ckad160.597</a>.
  short: S. Rella, Y. Kulikova, A. Minnegalieva, F. Kondrashov, in:, European Journal
    of Public Health, Oxford University Press, 2023.
date_created: 2024-01-22T12:02:28Z
date_published: 2023-10-01T00:00:00Z
date_updated: 2024-01-24T11:16:09Z
day: '01'
ddc:
- '570'
department:
- _id: GaTk
doi: 10.1093/eurpub/ckad160.597
file:
- access_level: open_access
  checksum: 98706755bb4cc5d553818ade7660a7d2
  content_type: application/pdf
  creator: dernst
  date_created: 2024-01-24T11:12:33Z
  date_updated: 2024-01-24T11:12:33Z
  file_id: '14882'
  file_name: 2023_EurJourPublicHealth_Rella.pdf
  file_size: 71057
  relation: main_file
  success: 1
file_date_updated: 2024-01-24T11:12:33Z
has_accepted_license: '1'
intvolume: '        33'
issue: Supplement_2
keyword:
- Public Health
- Environmental and Occupational Health
language:
- iso: eng
license: https://creativecommons.org/licenses/by-nc/4.0/
month: '10'
oa: 1
oa_version: Published Version
publication: European Journal of Public Health
publication_identifier:
  eissn:
  - 1464-360X
  issn:
  - 1101-1262
publication_status: published
publisher: Oxford University Press
quality_controlled: '1'
status: public
title: Complex vaccination strategies prevent the emergence of vaccine resistance
tmp:
  image: /images/cc_by_nc.png
  legal_code_url: https://creativecommons.org/licenses/by-nc/4.0/legalcode
  name: Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)
  short: CC BY-NC (4.0)
type: conference_abstract
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 33
year: '2023'
...
---
_id: '12131'
abstract:
- lang: eng
  text: Replication-incompetent adenoviral vectors have been extensively used as a
    platform for vaccine design, with at least four anti-COVID-19 vaccines authorized
    to date. These vaccines elicit neutralizing antibody responses directed against
    SARS-CoV-2 Spike protein and confer significant level of protection against SARS-CoV-2
    infection. Immunization with adenovirus-vectored vaccines is known to be accompanied
    by the production of anti-vector antibodies, which may translate into reduced
    efficacy of booster or repeated rounds of revaccination. Here, we used blood samples
    from patients who received an adenovirus-based Gam-COVID-Vac vaccine to address
    the question of whether anti-vector antibodies may influence the magnitude of
    SARS-CoV-2-specific humoral response after booster vaccination. We observed that
    rAd26-based prime vaccination with Gam-COVID-Vac induced the development of Ad26-neutralizing
    antibodies, which persisted in circulation for at least 9 months. Our analysis
    further indicates that high pre-boost Ad26 neutralizing antibody titers do not
    appear to affect the humoral immunogenicity of the Gam-COVID-Vac boost. The titers
    of anti-SARS-CoV-2 RBD IgGs and antibodies, which neutralized both the wild type
    and the circulating variants of concern of SARS-CoV-2 such as Delta and Omicron,
    were independent of the pre-boost levels of Ad26-neutralizing antibodies. Thus,
    our results support the development of repeated immunization schedule with adenovirus-based
    COVID-19 vaccines.
acknowledgement: We thank Sergey Kulemzin, Grigory Efimov, Yuri Lebedin, Alexander
  Taranin and Rudolf Valenta for providing reagents. Figures were created with the
  help of BioRender.com. This work was supported by the Russian Science Foundation
  (Project 21-15-00286). Byazrova M.G. was supported by the RUDN University Strategic
  Academic Leadership Program.
article_number: '145'
article_processing_charge: No
article_type: original
author:
- first_name: Maria G.
  full_name: Byazrova, Maria G.
  last_name: Byazrova
- first_name: Ekaterina A.
  full_name: Astakhova, Ekaterina A.
  last_name: Astakhova
- first_name: Aygul
  full_name: Minnegalieva, Aygul
  id: 87DF77F0-1D9A-11EA-B6AE-CE443DDC885E
  last_name: Minnegalieva
- first_name: Maria M.
  full_name: Sukhova, Maria M.
  last_name: Sukhova
- first_name: Artem A.
  full_name: Mikhailov, Artem A.
  last_name: Mikhailov
- first_name: Alexey G.
  full_name: Prilipov, Alexey G.
  last_name: Prilipov
- first_name: Andrey A.
  full_name: Gorchakov, Andrey A.
  last_name: Gorchakov
- first_name: Alexander V.
  full_name: Filatov, Alexander V.
  last_name: Filatov
citation:
  ama: Byazrova MG, Astakhova EA, Minnegalieva A, et al. Anti-Ad26 humoral immunity
    does not compromise SARS-COV-2 neutralizing antibody responses following Gam-COVID-Vac
    booster vaccination. <i>npj Vaccines</i>. 2022;7. doi:<a href="https://doi.org/10.1038/s41541-022-00566-x">10.1038/s41541-022-00566-x</a>
  apa: Byazrova, M. G., Astakhova, E. A., Minnegalieva, A., Sukhova, M. M., Mikhailov,
    A. A., Prilipov, A. G., … Filatov, A. V. (2022). Anti-Ad26 humoral immunity does
    not compromise SARS-COV-2 neutralizing antibody responses following Gam-COVID-Vac
    booster vaccination. <i>Npj Vaccines</i>. Springer Nature. <a href="https://doi.org/10.1038/s41541-022-00566-x">https://doi.org/10.1038/s41541-022-00566-x</a>
  chicago: Byazrova, Maria G., Ekaterina A. Astakhova, Aygul Minnegalieva, Maria M.
    Sukhova, Artem A. Mikhailov, Alexey G. Prilipov, Andrey A. Gorchakov, and Alexander
    V. Filatov. “Anti-Ad26 Humoral Immunity Does Not Compromise SARS-COV-2 Neutralizing
    Antibody Responses Following Gam-COVID-Vac Booster Vaccination.” <i>Npj Vaccines</i>.
    Springer Nature, 2022. <a href="https://doi.org/10.1038/s41541-022-00566-x">https://doi.org/10.1038/s41541-022-00566-x</a>.
  ieee: M. G. Byazrova <i>et al.</i>, “Anti-Ad26 humoral immunity does not compromise
    SARS-COV-2 neutralizing antibody responses following Gam-COVID-Vac booster vaccination,”
    <i>npj Vaccines</i>, vol. 7. Springer Nature, 2022.
  ista: Byazrova MG, Astakhova EA, Minnegalieva A, Sukhova MM, Mikhailov AA, Prilipov
    AG, Gorchakov AA, Filatov AV. 2022. Anti-Ad26 humoral immunity does not compromise
    SARS-COV-2 neutralizing antibody responses following Gam-COVID-Vac booster vaccination.
    npj Vaccines. 7, 145.
  mla: Byazrova, Maria G., et al. “Anti-Ad26 Humoral Immunity Does Not Compromise
    SARS-COV-2 Neutralizing Antibody Responses Following Gam-COVID-Vac Booster Vaccination.”
    <i>Npj Vaccines</i>, vol. 7, 145, Springer Nature, 2022, doi:<a href="https://doi.org/10.1038/s41541-022-00566-x">10.1038/s41541-022-00566-x</a>.
  short: M.G. Byazrova, E.A. Astakhova, A. Minnegalieva, M.M. Sukhova, A.A. Mikhailov,
    A.G. Prilipov, A.A. Gorchakov, A.V. Filatov, Npj Vaccines 7 (2022).
date_created: 2023-01-12T12:02:54Z
date_published: 2022-11-15T00:00:00Z
date_updated: 2023-08-04T08:52:40Z
day: '15'
ddc:
- '570'
department:
- _id: FyKo
doi: 10.1038/s41541-022-00566-x
external_id:
  isi:
  - '000884278600004'
  pmid:
  - '36379998'
file:
- access_level: open_access
  checksum: ddaac096381565b2b4b7dcc34cdbc4ee
  content_type: application/pdf
  creator: dernst
  date_created: 2023-01-23T11:22:09Z
  date_updated: 2023-01-23T11:22:09Z
  file_id: '12347'
  file_name: 2022_njpVaccines_Byazrova.pdf
  file_size: 1856046
  relation: main_file
  success: 1
file_date_updated: 2023-01-23T11:22:09Z
has_accepted_license: '1'
intvolume: '         7'
isi: 1
keyword:
- Pharmacology (medical)
- Infectious Diseases
- Pharmacology
- Immunology
- SARS-COV-2
- COVID
language:
- iso: eng
month: '11'
oa: 1
oa_version: Published Version
pmid: 1
publication: npj Vaccines
publication_identifier:
  issn:
  - 2059-0105
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: Anti-Ad26 humoral immunity does not compromise SARS-COV-2 neutralizing antibody
  responses following Gam-COVID-Vac booster vaccination
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 7
year: '2022'
...