---
_id: '14757'
abstract:
- lang: eng
  text: The cerebral cortex is comprised of a vast cell-type diversity sequentially
    generated by cortical progenitor cells. Faithful progenitor lineage progression
    requires the tight orchestration of distinct molecular and cellular mechanisms
    regulating proper progenitor proliferation behavior and differentiation. Correct
    execution of developmental programs involves a complex interplay of cell intrinsic
    and tissue-wide mechanisms. Many studies over the past decades have been able
    to determine a plethora of genes critically involved in cortical development.
    However, only a few made use of genetic paradigms with sparse and global gene
    deletion to probe cell-autonomous vs. tissue-wide contribution. In this chapter,
    we will elaborate on the importance of dissecting the cell-autonomous and tissue-wide
    mechanisms to gain a precise understanding of gene function during radial glial
    progenitor lineage progression.
article_processing_charge: No
author:
- first_name: Ana
  full_name: Villalba Requena, Ana
  id: 68cb85a0-39f7-11eb-9559-9aaab4f6a247
  last_name: Villalba Requena
  orcid: 0000-0002-5615-5277
- first_name: Nicole
  full_name: Amberg, Nicole
  id: 4CD6AAC6-F248-11E8-B48F-1D18A9856A87
  last_name: Amberg
  orcid: 0000-0002-3183-8207
- first_name: Simon
  full_name: Hippenmeyer, Simon
  id: 37B36620-F248-11E8-B48F-1D18A9856A87
  last_name: Hippenmeyer
  orcid: 0000-0003-2279-1061
citation:
  ama: 'Villalba Requena A, Amberg N, Hippenmeyer S. Interplay of Cell‐autonomous
    Gene Function and Tissue‐wide Mechanisms Regulating Radial Glial Progenitor Lineage
    Progression. In: Huttner W, ed. <i>Neocortical Neurogenesis in Development and
    Evolution</i>. Wiley; 2023:169-191. doi:<a href="https://doi.org/10.1002/9781119860914.ch10">10.1002/9781119860914.ch10</a>'
  apa: Villalba Requena, A., Amberg, N., &#38; Hippenmeyer, S. (2023). Interplay of
    Cell‐autonomous Gene Function and Tissue‐wide Mechanisms Regulating Radial Glial
    Progenitor Lineage Progression. In W. Huttner (Ed.), <i>Neocortical Neurogenesis
    in Development and Evolution</i> (pp. 169–191). Wiley. <a href="https://doi.org/10.1002/9781119860914.ch10">https://doi.org/10.1002/9781119860914.ch10</a>
  chicago: Villalba Requena, Ana, Nicole Amberg, and Simon Hippenmeyer. “Interplay
    of Cell‐autonomous Gene Function and Tissue‐wide Mechanisms Regulating Radial
    Glial Progenitor Lineage Progression.” In <i>Neocortical Neurogenesis in Development
    and Evolution</i>, edited by Wieland Huttner, 169–91. Wiley, 2023. <a href="https://doi.org/10.1002/9781119860914.ch10">https://doi.org/10.1002/9781119860914.ch10</a>.
  ieee: A. Villalba Requena, N. Amberg, and S. Hippenmeyer, “Interplay of Cell‐autonomous
    Gene Function and Tissue‐wide Mechanisms Regulating Radial Glial Progenitor Lineage
    Progression,” in <i>Neocortical Neurogenesis in Development and Evolution</i>,
    W. Huttner, Ed. Wiley, 2023, pp. 169–191.
  ista: 'Villalba Requena A, Amberg N, Hippenmeyer S. 2023.Interplay of Cell‐autonomous
    Gene Function and Tissue‐wide Mechanisms Regulating Radial Glial Progenitor Lineage
    Progression. In: Neocortical Neurogenesis in Development and Evolution. , 169–191.'
  mla: Villalba Requena, Ana, et al. “Interplay of Cell‐autonomous Gene Function and
    Tissue‐wide Mechanisms Regulating Radial Glial Progenitor Lineage Progression.”
    <i>Neocortical Neurogenesis in Development and Evolution</i>, edited by Wieland
    Huttner, Wiley, 2023, pp. 169–91, doi:<a href="https://doi.org/10.1002/9781119860914.ch10">10.1002/9781119860914.ch10</a>.
  short: A. Villalba Requena, N. Amberg, S. Hippenmeyer, in:, W. Huttner (Ed.), Neocortical
    Neurogenesis in Development and Evolution, Wiley, 2023, pp. 169–191.
date_created: 2024-01-08T13:16:36Z
date_published: 2023-08-08T00:00:00Z
date_updated: 2024-01-09T09:46:57Z
day: '08'
department:
- _id: SiHi
doi: 10.1002/9781119860914.ch10
editor:
- first_name: Wieland
  full_name: Huttner, Wieland
  last_name: Huttner
language:
- iso: eng
month: '08'
oa_version: None
page: 169-191
publication: Neocortical Neurogenesis in Development and Evolution
publication_identifier:
  eisbn:
  - '9781119860914'
publication_status: published
publisher: Wiley
quality_controlled: '1'
scopus_import: '1'
status: public
title: Interplay of Cell‐autonomous Gene Function and Tissue‐wide Mechanisms Regulating
  Radial Glial Progenitor Lineage Progression
type: book_chapter
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2023'
...
---
_id: '12542'
abstract:
- lang: eng
  text: In this issue of Neuron, Espinosa-Medina et al.1 present the TEMPO (Temporal
    Encoding and Manipulation in a Predefined Order) system, which enables the marking
    and genetic manipulation of sequentially generated cell lineages in vertebrate
    species in vivo.
article_processing_charge: No
article_type: letter_note
author:
- first_name: Ana
  full_name: Villalba Requena, Ana
  id: 68cb85a0-39f7-11eb-9559-9aaab4f6a247
  last_name: Villalba Requena
  orcid: 0000-0002-5615-5277
- first_name: Simon
  full_name: Hippenmeyer, Simon
  id: 37B36620-F248-11E8-B48F-1D18A9856A87
  last_name: Hippenmeyer
  orcid: 0000-0003-2279-1061
citation:
  ama: Villalba Requena A, Hippenmeyer S. Going back in time with TEMPO. <i>Neuron</i>.
    2023;111(3):291-293. doi:<a href="https://doi.org/10.1016/j.neuron.2023.01.006">10.1016/j.neuron.2023.01.006</a>
  apa: Villalba Requena, A., &#38; Hippenmeyer, S. (2023). Going back in time with
    TEMPO. <i>Neuron</i>. Elsevier. <a href="https://doi.org/10.1016/j.neuron.2023.01.006">https://doi.org/10.1016/j.neuron.2023.01.006</a>
  chicago: Villalba Requena, Ana, and Simon Hippenmeyer. “Going Back in Time with
    TEMPO.” <i>Neuron</i>. Elsevier, 2023. <a href="https://doi.org/10.1016/j.neuron.2023.01.006">https://doi.org/10.1016/j.neuron.2023.01.006</a>.
  ieee: A. Villalba Requena and S. Hippenmeyer, “Going back in time with TEMPO,” <i>Neuron</i>,
    vol. 111, no. 3. Elsevier, pp. 291–293, 2023.
  ista: Villalba Requena A, Hippenmeyer S. 2023. Going back in time with TEMPO. Neuron.
    111(3), 291–293.
  mla: Villalba Requena, Ana, and Simon Hippenmeyer. “Going Back in Time with TEMPO.”
    <i>Neuron</i>, vol. 111, no. 3, Elsevier, 2023, pp. 291–93, doi:<a href="https://doi.org/10.1016/j.neuron.2023.01.006">10.1016/j.neuron.2023.01.006</a>.
  short: A. Villalba Requena, S. Hippenmeyer, Neuron 111 (2023) 291–293.
date_created: 2023-02-12T23:00:58Z
date_published: 2023-02-01T00:00:00Z
date_updated: 2023-08-01T13:10:27Z
day: '01'
department:
- _id: SiHi
doi: 10.1016/j.neuron.2023.01.006
external_id:
  isi:
  - '000994473300001'
intvolume: '       111'
isi: 1
issue: '3'
language:
- iso: eng
month: '02'
oa_version: None
page: 291-293
publication: Neuron
publication_identifier:
  eissn:
  - 1097-4199
publication_status: published
publisher: Elsevier
quality_controlled: '1'
scopus_import: '1'
status: public
title: Going back in time with TEMPO
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 111
year: '2023'
...