---
_id: '14361'
abstract:
- lang: eng
  text: Whether one considers swarming insects, flocking birds, or bacterial colonies,
    collective motion arises from the coordination of individuals and entails the
    adjustment of their respective velocities. In particular, in close confinements,
    such as those encountered by dense cell populations during development or regeneration,
    collective migration can only arise coordinately. Yet, how individuals unify their
    velocities is often not understood. Focusing on a finite number of cells in circular
    confinements, we identify waves of polymerizing actin that function as a pacemaker
    governing the speed of individual cells. We show that the onset of collective
    motion coincides with the synchronization of the wave nucleation frequencies across
    the population. Employing a simpler and more readily accessible mechanical model
    system of active spheres, we identify the synchronization of the individuals’
    internal oscillators as one of the essential requirements to reach the corresponding
    collective state. The mechanical ‘toy’ experiment illustrates that the global
    synchronous state is achieved by nearest neighbor coupling. We suggest by analogy
    that local coupling and the synchronization of actin waves are essential for the
    emergent, self-organized motion of cell collectives.
acknowledged_ssus:
- _id: Bio
- _id: LifeSc
- _id: M-Shop
acknowledgement: We thank K. O’Keeffe, E. Hannezo, P. Devreotes, C. Dessalles, and
  E. Martens for discussion and/or critical reading of the manuscript; the Bioimaging
  Facility of ISTA for excellent support, as well as the Life Science Facility and
  the Miba Machine Shop of ISTA. This work was supported by the European Research
  Council (ERC StG 281556 and CoG 724373) to M.S.
article_number: '5633'
article_processing_charge: Yes
article_type: original
author:
- first_name: Michael
  full_name: Riedl, Michael
  id: 3BE60946-F248-11E8-B48F-1D18A9856A87
  last_name: Riedl
  orcid: 0000-0003-4844-6311
- first_name: Isabelle D
  full_name: Mayer, Isabelle D
  id: 61763940-15b2-11ec-abd3-cfaddfbc66b4
  last_name: Mayer
- first_name: Jack
  full_name: Merrin, Jack
  id: 4515C308-F248-11E8-B48F-1D18A9856A87
  last_name: Merrin
  orcid: 0000-0001-5145-4609
- first_name: Michael K
  full_name: Sixt, Michael K
  id: 41E9FBEA-F248-11E8-B48F-1D18A9856A87
  last_name: Sixt
  orcid: 0000-0002-6620-9179
- first_name: Björn
  full_name: Hof, Björn
  id: 3A374330-F248-11E8-B48F-1D18A9856A87
  last_name: Hof
  orcid: 0000-0003-2057-2754
citation:
  ama: Riedl M, Mayer ID, Merrin J, Sixt MK, Hof B. Synchronization in collectively
    moving inanimate and living active matter. <i>Nature Communications</i>. 2023;14.
    doi:<a href="https://doi.org/10.1038/s41467-023-41432-1">10.1038/s41467-023-41432-1</a>
  apa: Riedl, M., Mayer, I. D., Merrin, J., Sixt, M. K., &#38; Hof, B. (2023). Synchronization
    in collectively moving inanimate and living active matter. <i>Nature Communications</i>.
    Springer Nature. <a href="https://doi.org/10.1038/s41467-023-41432-1">https://doi.org/10.1038/s41467-023-41432-1</a>
  chicago: Riedl, Michael, Isabelle D Mayer, Jack Merrin, Michael K Sixt, and Björn
    Hof. “Synchronization in Collectively Moving Inanimate and Living Active Matter.”
    <i>Nature Communications</i>. Springer Nature, 2023. <a href="https://doi.org/10.1038/s41467-023-41432-1">https://doi.org/10.1038/s41467-023-41432-1</a>.
  ieee: M. Riedl, I. D. Mayer, J. Merrin, M. K. Sixt, and B. Hof, “Synchronization
    in collectively moving inanimate and living active matter,” <i>Nature Communications</i>,
    vol. 14. Springer Nature, 2023.
  ista: Riedl M, Mayer ID, Merrin J, Sixt MK, Hof B. 2023. Synchronization in collectively
    moving inanimate and living active matter. Nature Communications. 14, 5633.
  mla: Riedl, Michael, et al. “Synchronization in Collectively Moving Inanimate and
    Living Active Matter.” <i>Nature Communications</i>, vol. 14, 5633, Springer Nature,
    2023, doi:<a href="https://doi.org/10.1038/s41467-023-41432-1">10.1038/s41467-023-41432-1</a>.
  short: M. Riedl, I.D. Mayer, J. Merrin, M.K. Sixt, B. Hof, Nature Communications
    14 (2023).
date_created: 2023-09-24T22:01:10Z
date_published: 2023-09-13T00:00:00Z
date_updated: 2023-12-13T12:29:41Z
day: '13'
ddc:
- '530'
- '570'
department:
- _id: MiSi
- _id: NanoFab
- _id: BjHo
doi: 10.1038/s41467-023-41432-1
ec_funded: 1
external_id:
  isi:
  - '001087583700030'
  pmid:
  - '37704595'
file:
- access_level: open_access
  checksum: 82d2d4ad736cc8493db8ce45cd313f7b
  content_type: application/pdf
  creator: dernst
  date_created: 2023-09-25T08:32:37Z
  date_updated: 2023-09-25T08:32:37Z
  file_id: '14366'
  file_name: 2023_NatureComm_Riedl.pdf
  file_size: 2317272
  relation: main_file
  success: 1
file_date_updated: 2023-09-25T08:32:37Z
has_accepted_license: '1'
intvolume: '        14'
isi: 1
language:
- iso: eng
license: https://creativecommons.org/licenses/by/4.0/
month: '09'
oa: 1
oa_version: Published Version
pmid: 1
project:
- _id: 25A603A2-B435-11E9-9278-68D0E5697425
  call_identifier: FP7
  grant_number: '281556'
  name: Cytoskeletal force generation and force transduction of migrating leukocytes
- _id: 25FE9508-B435-11E9-9278-68D0E5697425
  call_identifier: H2020
  grant_number: '724373'
  name: Cellular navigation along spatial gradients
publication: Nature Communications
publication_identifier:
  eissn:
  - 2041-1723
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: Synchronization in collectively moving inanimate and living active matter
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 14
year: '2023'
...