---
_id: '15016'
abstract:
- lang: eng
text: 'The development, evolution, and function of the vertebrate central nervous
system (CNS) can be best studied using diverse model organisms. Amphibians, with
their unique phylogenetic position at the transition between aquatic and terrestrial
lifestyles, are valuable for understanding the origin and evolution of the tetrapod
brain and spinal cord. Their metamorphic developmental transitions and unique
regenerative abilities also facilitate the discovery of mechanisms for neural
circuit remodeling and replacement. The genetic toolkit for amphibians, however,
remains limited, with only a few species having sequenced genomes and a small
number of transgenic lines available. In mammals, recombinant adeno-associated
viral vectors (AAVs) have become a powerful alternative to genome modification
for visualizing and perturbing the nervous system. AAVs are DNA viruses that enable
neuronal transduction in both developing and adult animals with low toxicity and
spatial, temporal, and cell-type specificity. However, AAVs have never been shown
to transduce amphibian cells efficiently. To bridge this gap, we established a
simple, scalable, and robust strategy to screen AAV serotypes in three distantly-related
amphibian species: the frogs Xenopus laevis and Pelophylax bedriagae, and the
salamander Pleurodeles waltl, in both developing larval tadpoles and post-metamorphic
animals. For each species, we successfully identified at least two AAV serotypes
capable of infecting the CNS; however, no pan-amphibian serotype was identified,
indicating rapid evolution of AAV tropism. In addition, we developed an AAV-based
strategy that targets isochronic cohorts of developing neurons – a critical tool
for parsing neural circuit assembly. Finally, to enable visualization and manipulation
of neural circuits, we identified AAV variants for retrograde tracing of neuronal
projections in adult animals. Our findings expand the toolkit for amphibians to
include AAVs, establish a generalizable workflow for AAV screening in non-canonical
research organisms, generate testable hypotheses for the evolution of AAV tropism,
and lay the foundation for modern cross-species comparisons of vertebrate CNS
development, function, and evolution. '
acknowledgement: "We would like to extend our thanks to members of the Sweeney, Tosches,
Shein-Idelson,\r\nYamaguchi, Kelley, and Cline Labs for their contributions to this
project, discussion and support.\r\nWe additionally thank the Beckman Institute
Clover Center and Viviana Gradinaru (Caltech),\r\nKimberly Ritola (UNC NeuroTools),
Flavia Gama Gomez Leite (ISTA Viral Core), and Hüseyin\r\nCihan Önal (Shigemoto
Group, ISTA) for their consultation and assistance regarding AAVs, as\r\nwell as
Andras Simon and Alberto Joven for feedback and discussions on AAVs in Pleurodeles.\r\nTo
do these experiments, we have also benefited from the tremendous support of our
animal care and imaging facilities at our respective institutions, as well as the
amphibian stock centers\r\n(National Xenopus Resource Center, European Xenopus Resource
Center, Xenopus Express)\r\nand our funding sources: U.S. National Science Foundation
(NSF) Grant Number IOS 2110086\r\n(D.B.K., L.B.S., M.A.T., A.Y., and H.T.C.); United
States-Israel Binational Science Foundation\r\n(BSF) Grant Number 2020702 (M.S.-I.);
NSF Award Number 1645105 (G.J.G., M.E.H.); FTI\r\nStrategy Lower Austria Dissertation
Grant Number FTI21-D-046 (D.V.); Horizon Europe ERC\r\nStarting Grant Number 101041551
(L.B.S.); NIH grant number R35GM146973 (M.A.T.); Rita Allen\r\nFoundation award
number GA_032522_FE (M.A.T.); European Molecular Biology Organization\r\nLong-Term
Fellowship ALTF 874-2021 (A.D.); National Science Foundation Graduate Research\r\nFellowship
DGE 2036197 (E.C.J.B.); NIH grant number P40OD010997 (M.E.H)."
article_processing_charge: No
author:
- first_name: Eliza C.B.
full_name: Jaeger, Eliza C.B.
last_name: Jaeger
- first_name: David
full_name: Vijatovic, David
id: cf391e77-ec3c-11ea-a124-d69323410b58
last_name: Vijatovic
- first_name: Astrid
full_name: Deryckere, Astrid
last_name: Deryckere
- first_name: Nikol
full_name: Zorin, Nikol
last_name: Zorin
- first_name: Akemi L.
full_name: Nguyen, Akemi L.
last_name: Nguyen
- first_name: Georgiy
full_name: Ivanian, Georgiy
id: eaf2b366-cfd1-11ee-bbdf-c8790f800a05
last_name: Ivanian
- first_name: Jamie
full_name: Woych, Jamie
last_name: Woych
- first_name: Rebecca C
full_name: Arnold, Rebecca C
id: d6cce458-14c9-11ed-a755-c1c8fc6fde6f
last_name: Arnold
- first_name: Alonso
full_name: Ortega Gurrola, Alonso
last_name: Ortega Gurrola
- first_name: Arik
full_name: Shvartsman, Arik
last_name: Shvartsman
- first_name: Francesca
full_name: Barbieri, Francesca
id: a9492887-8972-11ed-ae7b-bfae10998254
last_name: Barbieri
- first_name: Florina-Alexandra
full_name: Toma, Florina-Alexandra
id: 85dd99f2-15b2-11ec-abd3-d1ae4d57f3b5
last_name: Toma
- first_name: Gary J.
full_name: Gorbsky, Gary J.
last_name: Gorbsky
- first_name: Marko E.
full_name: Horb, Marko E.
last_name: Horb
- first_name: Hollis T.
full_name: Cline, Hollis T.
last_name: Cline
- first_name: Timothy F.
full_name: Shay, Timothy F.
last_name: Shay
- first_name: Darcy B.
full_name: Kelley, Darcy B.
last_name: Kelley
- first_name: Ayako
full_name: Yamaguchi, Ayako
last_name: Yamaguchi
- first_name: Mark
full_name: Shein-Idelson, Mark
last_name: Shein-Idelson
- first_name: Maria Antonietta
full_name: Tosches, Maria Antonietta
last_name: Tosches
- first_name: Lora Beatrice Jaeger
full_name: Sweeney, Lora Beatrice Jaeger
id: 56BE8254-C4F0-11E9-8E45-0B23E6697425
last_name: Sweeney
orcid: 0000-0001-9242-5601
citation:
ama: Jaeger ECB, Vijatovic D, Deryckere A, et al. Adeno-associated viral tools to
trace neural development and connectivity across amphibians. bioRxiv. doi:10.1101/2024.02.15.580289
apa: Jaeger, E. C. B., Vijatovic, D., Deryckere, A., Zorin, N., Nguyen, A. L., Ivanian,
G., … Sweeney, L. B. (n.d.). Adeno-associated viral tools to trace neural development
and connectivity across amphibians. bioRxiv. https://doi.org/10.1101/2024.02.15.580289
chicago: Jaeger, Eliza C.B., David Vijatovic, Astrid Deryckere, Nikol Zorin, Akemi
L. Nguyen, Georgiy Ivanian, Jamie Woych, et al. “Adeno-Associated Viral Tools
to Trace Neural Development and Connectivity across Amphibians.” BioRxiv,
n.d. https://doi.org/10.1101/2024.02.15.580289.
ieee: E. C. B. Jaeger et al., “Adeno-associated viral tools to trace neural
development and connectivity across amphibians,” bioRxiv. .
ista: Jaeger ECB, Vijatovic D, Deryckere A, Zorin N, Nguyen AL, Ivanian G, Woych
J, Arnold RC, Ortega Gurrola A, Shvartsman A, Barbieri F, Toma F-A, Gorbsky GJ,
Horb ME, Cline HT, Shay TF, Kelley DB, Yamaguchi A, Shein-Idelson M, Tosches MA,
Sweeney LB. Adeno-associated viral tools to trace neural development and connectivity
across amphibians. bioRxiv, 10.1101/2024.02.15.580289.
mla: Jaeger, Eliza C. B., et al. “Adeno-Associated Viral Tools to Trace Neural Development
and Connectivity across Amphibians.” BioRxiv, doi:10.1101/2024.02.15.580289.
short: E.C.B. Jaeger, D. Vijatovic, A. Deryckere, N. Zorin, A.L. Nguyen, G. Ivanian,
J. Woych, R.C. Arnold, A. Ortega Gurrola, A. Shvartsman, F. Barbieri, F.-A. Toma,
G.J. Gorbsky, M.E. Horb, H.T. Cline, T.F. Shay, D.B. Kelley, A. Yamaguchi, M.
Shein-Idelson, M.A. Tosches, L.B. Sweeney, BioRxiv (n.d.).
date_created: 2024-02-20T09:20:32Z
date_published: 2024-02-16T00:00:00Z
date_updated: 2024-02-20T09:34:25Z
day: '16'
department:
- _id: LoSw
- _id: MaDe
- _id: GaNo
doi: 10.1101/2024.02.15.580289
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1101/2024.02.15.580289
month: '02'
oa: 1
oa_version: Preprint
project:
- _id: bd73af52-d553-11ed-ba76-912049f0ac7a
grant_number: FTI21-D-046
name: Entwicklung und Funktion der V1 Interneuronen vom Schwimmen zum Laufen während
der Metamorphose von Xenopus
- _id: ebb66355-77a9-11ec-83b8-b8ac210a4dae
grant_number: '101041551'
name: Development and Evolution of Tetrapod Motor Circuits
publication: bioRxiv
publication_status: submitted
status: public
title: Adeno-associated viral tools to trace neural development and connectivity across
amphibians
type: preprint
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2024'
...
---
_id: '13097'
abstract:
- lang: eng
text: 'Vertebrate movement is orchestrated by spinal inter- and motor neurons that,
together with sensory and cognitive input, produce dynamic motor behaviors. These
behaviors vary from the simple undulatory swimming of fish and larval aquatic
species to the highly coordinated running, reaching and grasping of mice, humans
and other mammals. This variation raises the fundamental question of how spinal
circuits have changed in register with motor behavior. In simple, undulatory fish,
exemplified by the lamprey, two broad classes of interneurons shape motor neuron
output: ipsilateral-projecting excitatory neurons, and commissural-projecting
inhibitory neurons. An additional class of ipsilateral inhibitory neurons is required
to generate escape swim behavior in larval zebrafish and tadpoles. In limbed vertebrates,
a more complex spinal neuron composition is observed. In this review, we provide
evidence that movement elaboration correlates with an increase and specialization
of these three basic interneuron types into molecularly, anatomically, and functionally
distinct subpopulations. We summarize recent work linking neuron types to movement-pattern
generation across fish, amphibians, reptiles, birds and mammals.'
acknowledgement: 'This work was supported by the ERC Starting grant, ERC-2021-STG
#101041551.'
article_number: '1146449'
article_processing_charge: Yes
article_type: original
author:
- first_name: Alexia C
full_name: Wilson, Alexia C
id: 5230e794-15b2-11ec-abd3-e2d5335ebd1d
last_name: Wilson
- first_name: Lora Beatrice Jaeger
full_name: Sweeney, Lora Beatrice Jaeger
id: 56BE8254-C4F0-11E9-8E45-0B23E6697425
last_name: Sweeney
orcid: 0000-0001-9242-5601
citation:
ama: 'Wilson AC, Sweeney LB. Spinal cords: Symphonies of interneurons across species.
Frontiers in Neural Circuits. 2023;17. doi:10.3389/fncir.2023.1146449'
apa: 'Wilson, A. C., & Sweeney, L. B. (2023). Spinal cords: Symphonies of interneurons
across species. Frontiers in Neural Circuits. Frontiers. https://doi.org/10.3389/fncir.2023.1146449'
chicago: 'Wilson, Alexia C, and Lora B. Sweeney. “Spinal Cords: Symphonies of Interneurons
across Species.” Frontiers in Neural Circuits. Frontiers, 2023. https://doi.org/10.3389/fncir.2023.1146449.'
ieee: 'A. C. Wilson and L. B. Sweeney, “Spinal cords: Symphonies of interneurons
across species,” Frontiers in Neural Circuits, vol. 17. Frontiers, 2023.'
ista: 'Wilson AC, Sweeney LB. 2023. Spinal cords: Symphonies of interneurons across
species. Frontiers in Neural Circuits. 17, 1146449.'
mla: 'Wilson, Alexia C., and Lora B. Sweeney. “Spinal Cords: Symphonies of Interneurons
across Species.” Frontiers in Neural Circuits, vol. 17, 1146449, Frontiers,
2023, doi:10.3389/fncir.2023.1146449.'
short: A.C. Wilson, L.B. Sweeney, Frontiers in Neural Circuits 17 (2023).
date_created: 2023-05-28T22:01:04Z
date_published: 2023-04-26T00:00:00Z
date_updated: 2024-01-31T10:15:53Z
day: '26'
ddc:
- '570'
department:
- _id: LoSw
doi: 10.3389/fncir.2023.1146449
external_id:
isi:
- '000984606200001'
pmid:
- '37180760'
file:
- access_level: open_access
checksum: 7efd06de284a28e91e97127611a9c3fd
content_type: application/pdf
creator: dernst
date_created: 2024-01-03T13:33:21Z
date_updated: 2024-01-03T13:33:21Z
file_id: '14729'
file_name: 2023_FrontiersNeuralCircuits_Wilson.pdf
file_size: 6667157
relation: main_file
success: 1
file_date_updated: 2024-01-03T13:33:21Z
has_accepted_license: '1'
intvolume: ' 17'
isi: 1
language:
- iso: eng
license: https://creativecommons.org/licenses/by/4.0/
month: '04'
oa: 1
oa_version: Published Version
pmid: 1
project:
- _id: ebb66355-77a9-11ec-83b8-b8ac210a4dae
grant_number: '101041551'
name: Development and Evolution of Tetrapod Motor Circuits
publication: Frontiers in Neural Circuits
publication_identifier:
issn:
- 1662-5110
publication_status: published
publisher: Frontiers
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Spinal cords: Symphonies of interneurons across species'
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 17
year: '2023'
...
---
_id: '8914'
abstract:
- lang: eng
text: Amyotrophic lateral sclerosis (ALS) leads to a loss of specific motor neuron
populations in the spinal cord and cortex. Emerging evidence suggests that interneurons
may also be affected, but a detailed characterization of interneuron loss and
its potential impacts on motor neuron loss and disease progression is lacking.
To examine this issue, the fate of V1 inhibitory neurons during ALS was assessed
in the ventral spinal cord using the SODG93A mouse model. The V1 population makes
up ∼30% of all ventral inhibitory neurons, ∼50% of direct inhibitory synaptic
contacts onto motor neuron cell bodies, and is thought to play a key role in modulating
motor output, in part through recurrent and reciprocal inhibitory circuits. We
find that approximately half of V1 inhibitory neurons are lost in SODG93A mice
at late disease stages, but that this loss is delayed relative to the loss of
motor neurons and V2a excitatory neurons. We further identify V1 subpopulations
based on transcription factor expression that are differentially susceptible to
degeneration in SODG93A mice. At an early disease stage, we show that V1 synaptic
contacts with motor neuron cell bodies increase, suggesting an upregulation of
inhibition before V1 neurons are lost in substantial numbers. These data support
a model in which progressive changes in V1 synaptic contacts early in disease,
and in select V1 subpopulations at later stages, represent a compensatory upregulation
and then deleterious breakdown of specific interneuron circuits within the spinal
cord.
acknowledgement: This work was made possible by the generous support of Project ALS.
Imaging and related analyses were facilitated by The Waitt Advanced Biophotonics
Center Core at the Salk Institute, supported by grants from NIH-NCI CCSG (P30 014195)
and NINDS Neuroscience Center (NS072031). The authors would like to additionally
thank Drs. Jane Dodd, Robert Brownstone, and Laskaro Zagoraiou for helpful comments
on the manuscript. This manuscript is dedicated to Tom Jessell, an inspirational
scientist, friend and mentor.
article_processing_charge: Yes (via OA deal)
article_type: original
author:
- first_name: Alina
full_name: Salamatina, Alina
last_name: Salamatina
- first_name: Jerry H
full_name: Yang, Jerry H
last_name: Yang
- first_name: Susan
full_name: Brenner-Morton, Susan
last_name: Brenner-Morton
- first_name: 'Jay B '
full_name: 'Bikoff, Jay B '
last_name: Bikoff
- first_name: Linjing
full_name: Fang, Linjing
last_name: Fang
- first_name: Christopher R
full_name: Kintner, Christopher R
last_name: Kintner
- first_name: Thomas M
full_name: Jessell, Thomas M
last_name: Jessell
- first_name: Lora Beatrice Jaeger
full_name: Sweeney, Lora Beatrice Jaeger
id: 56BE8254-C4F0-11E9-8E45-0B23E6697425
last_name: Sweeney
orcid: 0000-0001-9242-5601
citation:
ama: Salamatina A, Yang JH, Brenner-Morton S, et al. Differential loss of spinal
interneurons in a mouse model of ALS. Neuroscience. 2020;450:81-95. doi:10.1016/j.neuroscience.2020.08.011
apa: Salamatina, A., Yang, J. H., Brenner-Morton, S., Bikoff, J. B., Fang, L., Kintner,
C. R., … Sweeney, L. B. (2020). Differential loss of spinal interneurons in a
mouse model of ALS. Neuroscience. Elsevier. https://doi.org/10.1016/j.neuroscience.2020.08.011
chicago: Salamatina, Alina, Jerry H Yang, Susan Brenner-Morton, Jay B Bikoff, Linjing
Fang, Christopher R Kintner, Thomas M Jessell, and Lora B. Sweeney. “Differential
Loss of Spinal Interneurons in a Mouse Model of ALS.” Neuroscience. Elsevier,
2020. https://doi.org/10.1016/j.neuroscience.2020.08.011.
ieee: A. Salamatina et al., “Differential loss of spinal interneurons in
a mouse model of ALS,” Neuroscience, vol. 450. Elsevier, pp. 81–95, 2020.
ista: Salamatina A, Yang JH, Brenner-Morton S, Bikoff JB, Fang L, Kintner CR, Jessell
TM, Sweeney LB. 2020. Differential loss of spinal interneurons in a mouse model
of ALS. Neuroscience. 450, 81–95.
mla: Salamatina, Alina, et al. “Differential Loss of Spinal Interneurons in a Mouse
Model of ALS.” Neuroscience, vol. 450, Elsevier, 2020, pp. 81–95, doi:10.1016/j.neuroscience.2020.08.011.
short: A. Salamatina, J.H. Yang, S. Brenner-Morton, J.B. Bikoff, L. Fang, C.R. Kintner,
T.M. Jessell, L.B. Sweeney, Neuroscience 450 (2020) 81–95.
date_created: 2020-12-03T11:47:31Z
date_published: 2020-12-01T00:00:00Z
date_updated: 2024-01-31T10:15:34Z
day: '01'
ddc:
- '570'
department:
- _id: LoSw
doi: 10.1016/j.neuroscience.2020.08.011
external_id:
isi:
- '000595588700008'
pmid:
- '32858144'
file:
- access_level: open_access
checksum: da7413c819e079720669c82451b49294
content_type: application/pdf
creator: dernst
date_created: 2020-12-03T11:45:26Z
date_updated: 2020-12-03T11:45:26Z
file_id: '8915'
file_name: 2020_Neuroscience_Salamatina.pdf
file_size: 4071247
relation: main_file
success: 1
file_date_updated: 2020-12-03T11:45:26Z
has_accepted_license: '1'
intvolume: ' 450'
isi: 1
language:
- iso: eng
license: https://creativecommons.org/licenses/by-nc-nd/4.0/
month: '12'
oa: 1
oa_version: Published Version
page: 81-95
pmid: 1
publication: Neuroscience
publication_identifier:
issn:
- 0306-4522
publication_status: published
publisher: Elsevier
quality_controlled: '1'
scopus_import: '1'
status: public
title: Differential loss of spinal interneurons in a mouse model of ALS
tmp:
image: /images/cc_by_nc_nd.png
legal_code_url: https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode
name: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
(CC BY-NC-ND 4.0)
short: CC BY-NC-ND (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 450
year: '2020'
...
---
_id: '7698'
abstract:
- lang: eng
text: Motor output varies along the rostro-caudal axis of the tetrapod spinal cord.
At limb levels, ∼60 motor pools control the alternation of flexor and extensor
muscles about each joint, whereas at thoracic levels as few as 10 motor pools
supply muscle groups that support posture, inspiration, and expiration. Whether
such differences in motor neuron identity and muscle number are associated with
segmental distinctions in interneuron diversity has not been resolved. We show
that select combinations of nineteen transcription factors that specify lumbar
V1 inhibitory interneurons generate subpopulations enriched at limb and thoracic
levels. Specification of limb and thoracic V1 interneurons involves the Hox gene
Hoxc9 independently of motor neurons. Thus, early Hox patterning of the spinal
cord determines the identity of V1 interneurons and motor neurons. These studies
reveal a developmental program of V1 interneuron diversity, providing insight
into the organization of inhibitory interneurons associated with differential
motor output.
article_processing_charge: No
article_type: original
author:
- first_name: Lora Beatrice Jaeger
full_name: Sweeney, Lora Beatrice Jaeger
id: 56BE8254-C4F0-11E9-8E45-0B23E6697425
last_name: Sweeney
orcid: 0000-0001-9242-5601
- first_name: Jay B.
full_name: Bikoff, Jay B.
last_name: Bikoff
- first_name: Mariano I.
full_name: Gabitto, Mariano I.
last_name: Gabitto
- first_name: Susan
full_name: Brenner-Morton, Susan
last_name: Brenner-Morton
- first_name: Myungin
full_name: Baek, Myungin
last_name: Baek
- first_name: Jerry H.
full_name: Yang, Jerry H.
last_name: Yang
- first_name: Esteban G.
full_name: Tabak, Esteban G.
last_name: Tabak
- first_name: Jeremy S.
full_name: Dasen, Jeremy S.
last_name: Dasen
- first_name: Christopher R.
full_name: Kintner, Christopher R.
last_name: Kintner
- first_name: Thomas M.
full_name: Jessell, Thomas M.
last_name: Jessell
citation:
ama: Sweeney LB, Bikoff JB, Gabitto MI, et al. Origin and segmental diversity of
spinal inhibitory interneurons. Neuron. 2018;97(2):341-355.e3. doi:10.1016/j.neuron.2017.12.029
apa: Sweeney, L. B., Bikoff, J. B., Gabitto, M. I., Brenner-Morton, S., Baek, M.,
Yang, J. H., … Jessell, T. M. (2018). Origin and segmental diversity of spinal
inhibitory interneurons. Neuron. Elsevier. https://doi.org/10.1016/j.neuron.2017.12.029
chicago: Sweeney, Lora B., Jay B. Bikoff, Mariano I. Gabitto, Susan Brenner-Morton,
Myungin Baek, Jerry H. Yang, Esteban G. Tabak, Jeremy S. Dasen, Christopher R.
Kintner, and Thomas M. Jessell. “Origin and Segmental Diversity of Spinal Inhibitory
Interneurons.” Neuron. Elsevier, 2018. https://doi.org/10.1016/j.neuron.2017.12.029.
ieee: L. B. Sweeney et al., “Origin and segmental diversity of spinal inhibitory
interneurons,” Neuron, vol. 97, no. 2. Elsevier, p. 341–355.e3, 2018.
ista: Sweeney LB, Bikoff JB, Gabitto MI, Brenner-Morton S, Baek M, Yang JH, Tabak
EG, Dasen JS, Kintner CR, Jessell TM. 2018. Origin and segmental diversity of
spinal inhibitory interneurons. Neuron. 97(2), 341–355.e3.
mla: Sweeney, Lora B., et al. “Origin and Segmental Diversity of Spinal Inhibitory
Interneurons.” Neuron, vol. 97, no. 2, Elsevier, 2018, p. 341–355.e3, doi:10.1016/j.neuron.2017.12.029.
short: L.B. Sweeney, J.B. Bikoff, M.I. Gabitto, S. Brenner-Morton, M. Baek, J.H.
Yang, E.G. Tabak, J.S. Dasen, C.R. Kintner, T.M. Jessell, Neuron 97 (2018) 341–355.e3.
date_created: 2020-04-30T10:35:13Z
date_published: 2018-01-04T00:00:00Z
date_updated: 2024-01-31T10:13:54Z
day: '04'
doi: 10.1016/j.neuron.2017.12.029
extern: '1'
intvolume: ' 97'
issue: '2'
language:
- iso: eng
month: '01'
oa_version: None
page: 341-355.e3
publication: Neuron
publication_identifier:
issn:
- 0896-6273
publication_status: published
publisher: Elsevier
quality_controlled: '1'
status: public
title: Origin and segmental diversity of spinal inhibitory interneurons
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 97
year: '2018'
...
---
_id: '7699'
article_processing_charge: No
article_type: original
author:
- first_name: Lora Beatrice Jaeger
full_name: Sweeney, Lora Beatrice Jaeger
id: 56BE8254-C4F0-11E9-8E45-0B23E6697425
last_name: Sweeney
orcid: 0000-0001-9242-5601
- first_name: Darcy B
full_name: Kelley, Darcy B
last_name: Kelley
citation:
ama: Sweeney LB, Kelley DB. Harnessing vocal patterns for social communication.
Current Opinion in Neurobiology. 2014;28(10):34-41. doi:10.1016/j.conb.2014.06.006
apa: Sweeney, L. B., & Kelley, D. B. (2014). Harnessing vocal patterns for social
communication. Current Opinion in Neurobiology. Elsevier. https://doi.org/10.1016/j.conb.2014.06.006
chicago: Sweeney, Lora B., and Darcy B Kelley. “Harnessing Vocal Patterns for Social
Communication.” Current Opinion in Neurobiology. Elsevier, 2014. https://doi.org/10.1016/j.conb.2014.06.006.
ieee: L. B. Sweeney and D. B. Kelley, “Harnessing vocal patterns for social communication,”
Current Opinion in Neurobiology, vol. 28, no. 10. Elsevier, pp. 34–41,
2014.
ista: Sweeney LB, Kelley DB. 2014. Harnessing vocal patterns for social communication.
Current Opinion in Neurobiology. 28(10), 34–41.
mla: Sweeney, Lora B., and Darcy B. Kelley. “Harnessing Vocal Patterns for Social
Communication.” Current Opinion in Neurobiology, vol. 28, no. 10, Elsevier,
2014, pp. 34–41, doi:10.1016/j.conb.2014.06.006.
short: L.B. Sweeney, D.B. Kelley, Current Opinion in Neurobiology 28 (2014) 34–41.
date_created: 2020-04-30T10:35:39Z
date_published: 2014-10-01T00:00:00Z
date_updated: 2024-01-31T10:14:08Z
day: '01'
doi: 10.1016/j.conb.2014.06.006
extern: '1'
intvolume: ' 28'
issue: '10'
language:
- iso: eng
month: '10'
oa_version: None
page: 34-41
publication: Current Opinion in Neurobiology
publication_identifier:
issn:
- 0959-4388
publication_status: published
publisher: Elsevier
quality_controlled: '1'
status: public
title: Harnessing vocal patterns for social communication
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 28
year: '2014'
...
---
_id: '7785'
abstract:
- lang: eng
text: Neural circuit assembly requires selection of specific cell fates, axonal
trajectories, and synaptic targets. By analyzing the function of a secreted semaphorin,
Sema-2b, in Drosophila olfactory receptor neuron (ORN) development, we identified
multiple molecular and cellular mechanisms that link these events. Notch signaling
limits Sema-2b expression to ventromedial ORN classes, within which Sema-2b cell-autonomously
sensitizes ORN axons to external semaphorins. Central-brain-derived Sema-2a and
Sema-2b attract Sema-2b-expressing axons to the ventromedial trajectory. In addition,
Sema-2b/PlexB-mediated axon-axon interactions consolidate this trajectory choice
and promote ventromedial axon-bundle formation. Selecting the correct developmental
trajectory is ultimately essential for proper target choice. These findings demonstrate
that Sema-2b couples ORN axon guidance to postsynaptic target neuron dendrite
patterning well before the final target selection phase, and exemplify how a single
guidance molecule can drive consecutive stages of neural circuit assembly with
the help of sophisticated spatial and temporal regulation.
article_processing_charge: No
article_type: original
author:
- first_name: William J.
full_name: Joo, William J.
last_name: Joo
- first_name: Lora Beatrice Jaeger
full_name: Sweeney, Lora Beatrice Jaeger
id: 56BE8254-C4F0-11E9-8E45-0B23E6697425
last_name: Sweeney
orcid: 0000-0001-9242-5601
- first_name: Liang
full_name: Liang, Liang
last_name: Liang
- first_name: Liqun
full_name: Luo, Liqun
last_name: Luo
citation:
ama: 'Joo WJ, Sweeney LB, Liang L, Luo L. Linking cell fate, trajectory choice,
and target selection: Genetic analysis of sema-2b in olfactory axon targeting.
Neuron. 2013;78(4):673-686. doi:10.1016/j.neuron.2013.03.022'
apa: 'Joo, W. J., Sweeney, L. B., Liang, L., & Luo, L. (2013). Linking cell
fate, trajectory choice, and target selection: Genetic analysis of sema-2b in
olfactory axon targeting. Neuron. Elsevier. https://doi.org/10.1016/j.neuron.2013.03.022'
chicago: 'Joo, William J., Lora B. Sweeney, Liang Liang, and Liqun Luo. “Linking
Cell Fate, Trajectory Choice, and Target Selection: Genetic Analysis of Sema-2b
in Olfactory Axon Targeting.” Neuron. Elsevier, 2013. https://doi.org/10.1016/j.neuron.2013.03.022.'
ieee: 'W. J. Joo, L. B. Sweeney, L. Liang, and L. Luo, “Linking cell fate, trajectory
choice, and target selection: Genetic analysis of sema-2b in olfactory axon targeting,”
Neuron, vol. 78, no. 4. Elsevier, pp. 673–686, 2013.'
ista: 'Joo WJ, Sweeney LB, Liang L, Luo L. 2013. Linking cell fate, trajectory choice,
and target selection: Genetic analysis of sema-2b in olfactory axon targeting.
Neuron. 78(4), 673–686.'
mla: 'Joo, William J., et al. “Linking Cell Fate, Trajectory Choice, and Target
Selection: Genetic Analysis of Sema-2b in Olfactory Axon Targeting.” Neuron,
vol. 78, no. 4, Elsevier, 2013, pp. 673–86, doi:10.1016/j.neuron.2013.03.022.'
short: W.J. Joo, L.B. Sweeney, L. Liang, L. Luo, Neuron 78 (2013) 673–686.
date_created: 2020-04-30T13:19:59Z
date_published: 2013-05-22T00:00:00Z
date_updated: 2024-01-31T10:15:25Z
day: '22'
doi: 10.1016/j.neuron.2013.03.022
extern: '1'
intvolume: ' 78'
issue: '4'
language:
- iso: eng
month: '05'
oa_version: None
page: 673-686
publication: Neuron
publication_identifier:
issn:
- 0896-6273
publication_status: published
publisher: Elsevier
quality_controlled: '1'
status: public
title: 'Linking cell fate, trajectory choice, and target selection: Genetic analysis
of sema-2b in olfactory axon targeting'
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 78
year: '2013'
...
---
_id: '7701'
abstract:
- lang: eng
text: During assembly of the Drosophila olfactory circuit, projection neuron (PN)
dendrites prepattern the developing antennal lobe before the arrival of axons
from their presynaptic partners, the adult olfactory receptor neurons (ORNs).
We previously found that levels of transmembrane Semaphorin-1a, which acts as
a receptor, instruct PN dendrite targeting along the dorsolateral-ventromedial
axis. Here we show that two secreted semaphorins, Sema-2a and Sema-2b, provide
spatial cues for PN dendrite targeting. Sema-2a and Sema-2b proteins are distributed
in gradients opposing the Sema-1a protein gradient, and Sema-1a binds to Sema-2a-expressing
cells. In Sema-2a and Sema-2b double mutants, PN dendrites that normally target
dorsolaterally in the antennal lobe mistarget ventromedially, phenocopying cell-autonomous
Sema-1a removal from these PNs. Cell ablation, cell-specific knockdown, and rescue
experiments indicate that secreted semaphorins from degenerating larval ORN axons
direct dendrite targeting. Thus, a degenerating brain structure instructs the
wiring of a developing circuit through the repulsive action of secreted semaphorins.
article_processing_charge: No
article_type: original
author:
- first_name: Lora Beatrice Jaeger
full_name: Sweeney, Lora Beatrice Jaeger
id: 56BE8254-C4F0-11E9-8E45-0B23E6697425
last_name: Sweeney
orcid: 0000-0001-9242-5601
- first_name: Ya-Hui
full_name: Chou, Ya-Hui
last_name: Chou
- first_name: Zhuhao
full_name: Wu, Zhuhao
last_name: Wu
- first_name: William
full_name: Joo, William
last_name: Joo
- first_name: Takaki
full_name: Komiyama, Takaki
last_name: Komiyama
- first_name: Christopher J.
full_name: Potter, Christopher J.
last_name: Potter
- first_name: Alex L.
full_name: Kolodkin, Alex L.
last_name: Kolodkin
- first_name: K. Christopher
full_name: Garcia, K. Christopher
last_name: Garcia
- first_name: Liqun
full_name: Luo, Liqun
last_name: Luo
citation:
ama: Sweeney LB, Chou Y-H, Wu Z, et al. Secreted semaphorins from degenerating larval
ORN axons direct adult projection neuron dendrite targeting. Neuron. 2011;72(5):734-747.
doi:10.1016/j.neuron.2011.09.026
apa: Sweeney, L. B., Chou, Y.-H., Wu, Z., Joo, W., Komiyama, T., Potter, C. J.,
… Luo, L. (2011). Secreted semaphorins from degenerating larval ORN axons direct
adult projection neuron dendrite targeting. Neuron. Elsevier. https://doi.org/10.1016/j.neuron.2011.09.026
chicago: Sweeney, Lora B., Ya-Hui Chou, Zhuhao Wu, William Joo, Takaki Komiyama,
Christopher J. Potter, Alex L. Kolodkin, K. Christopher Garcia, and Liqun Luo.
“Secreted Semaphorins from Degenerating Larval ORN Axons Direct Adult Projection
Neuron Dendrite Targeting.” Neuron. Elsevier, 2011. https://doi.org/10.1016/j.neuron.2011.09.026.
ieee: L. B. Sweeney et al., “Secreted semaphorins from degenerating larval
ORN axons direct adult projection neuron dendrite targeting,” Neuron, vol.
72, no. 5. Elsevier, pp. 734–747, 2011.
ista: Sweeney LB, Chou Y-H, Wu Z, Joo W, Komiyama T, Potter CJ, Kolodkin AL, Garcia
KC, Luo L. 2011. Secreted semaphorins from degenerating larval ORN axons direct
adult projection neuron dendrite targeting. Neuron. 72(5), 734–747.
mla: Sweeney, Lora B., et al. “Secreted Semaphorins from Degenerating Larval ORN
Axons Direct Adult Projection Neuron Dendrite Targeting.” Neuron, vol.
72, no. 5, Elsevier, 2011, pp. 734–47, doi:10.1016/j.neuron.2011.09.026.
short: L.B. Sweeney, Y.-H. Chou, Z. Wu, W. Joo, T. Komiyama, C.J. Potter, A.L. Kolodkin,
K.C. Garcia, L. Luo, Neuron 72 (2011) 734–747.
date_created: 2020-04-30T10:36:12Z
date_published: 2011-12-08T00:00:00Z
date_updated: 2024-01-31T10:13:39Z
day: '08'
doi: 10.1016/j.neuron.2011.09.026
extern: '1'
intvolume: ' 72'
issue: '5'
language:
- iso: eng
month: '12'
oa_version: None
page: 734-747
publication: Neuron
publication_identifier:
issn:
- 0896-6273
publication_status: published
publisher: Elsevier
quality_controlled: '1'
status: public
title: Secreted semaphorins from degenerating larval ORN axons direct adult projection
neuron dendrite targeting
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 72
year: '2011'
...
---
_id: '7702'
abstract:
- lang: eng
text: Longitudinal axon fascicles within the Drosophila embryonic CNS provide connections
between body segments and are required for coordinated neural signaling along
the anterior-posterior axis. We show here that establishment of select CNS longitudinal
tracts and formation of precise mechanosensory afferent innervation to the same
CNS region are coordinately regulated by the secreted semaphorins Sema-2a and
Sema-2b. Both Sema-2a and Sema-2b utilize the same neuronal receptor, plexin B
(PlexB), but serve distinct guidance functions. Localized Sema-2b attraction promotes
the initial assembly of a subset of CNS longitudinal projections and subsequent
targeting of chordotonal sensory afferent axons to these same longitudinal connectives,
whereas broader Sema-2a repulsion serves to prevent aberrant innervation. In the
absence of Sema-2b or PlexB, chordotonal afferent connectivity within the CNS
is severely disrupted, resulting in specific larval behavioral deficits. These
results reveal that distinct semaphorin-mediated guidance functions converge at
PlexB and are critical for functional neural circuit assembly.
article_processing_charge: No
article_type: original
author:
- first_name: Zhuhao
full_name: Wu, Zhuhao
last_name: Wu
- first_name: Lora Beatrice Jaeger
full_name: Sweeney, Lora Beatrice Jaeger
id: 56BE8254-C4F0-11E9-8E45-0B23E6697425
last_name: Sweeney
orcid: 0000-0001-9242-5601
- first_name: Joseph C.
full_name: Ayoob, Joseph C.
last_name: Ayoob
- first_name: Kayam
full_name: Chak, Kayam
last_name: Chak
- first_name: Benjamin J.
full_name: Andreone, Benjamin J.
last_name: Andreone
- first_name: Tomoko
full_name: Ohyama, Tomoko
last_name: Ohyama
- first_name: Rex
full_name: Kerr, Rex
last_name: Kerr
- first_name: Liqun
full_name: Luo, Liqun
last_name: Luo
- first_name: Marta
full_name: Zlatic, Marta
last_name: Zlatic
- first_name: Alex L.
full_name: Kolodkin, Alex L.
last_name: Kolodkin
citation:
ama: Wu Z, Sweeney LB, Ayoob JC, et al. A combinatorial semaphorin code instructs
the initial steps of sensory circuit assembly in the Drosophila CNS. Neuron.
2011;70(2):281-298. doi:10.1016/j.neuron.2011.02.050
apa: Wu, Z., Sweeney, L. B., Ayoob, J. C., Chak, K., Andreone, B. J., Ohyama, T.,
… Kolodkin, A. L. (2011). A combinatorial semaphorin code instructs the initial
steps of sensory circuit assembly in the Drosophila CNS. Neuron. Elsevier.
https://doi.org/10.1016/j.neuron.2011.02.050
chicago: Wu, Zhuhao, Lora B. Sweeney, Joseph C. Ayoob, Kayam Chak, Benjamin J. Andreone,
Tomoko Ohyama, Rex Kerr, Liqun Luo, Marta Zlatic, and Alex L. Kolodkin. “A Combinatorial
Semaphorin Code Instructs the Initial Steps of Sensory Circuit Assembly in the
Drosophila CNS.” Neuron. Elsevier, 2011. https://doi.org/10.1016/j.neuron.2011.02.050.
ieee: Z. Wu et al., “A combinatorial semaphorin code instructs the initial
steps of sensory circuit assembly in the Drosophila CNS,” Neuron, vol.
70, no. 2. Elsevier, pp. 281–298, 2011.
ista: Wu Z, Sweeney LB, Ayoob JC, Chak K, Andreone BJ, Ohyama T, Kerr R, Luo L,
Zlatic M, Kolodkin AL. 2011. A combinatorial semaphorin code instructs the initial
steps of sensory circuit assembly in the Drosophila CNS. Neuron. 70(2), 281–298.
mla: Wu, Zhuhao, et al. “A Combinatorial Semaphorin Code Instructs the Initial Steps
of Sensory Circuit Assembly in the Drosophila CNS.” Neuron, vol. 70, no.
2, Elsevier, 2011, pp. 281–98, doi:10.1016/j.neuron.2011.02.050.
short: Z. Wu, L.B. Sweeney, J.C. Ayoob, K. Chak, B.J. Andreone, T. Ohyama, R. Kerr,
L. Luo, M. Zlatic, A.L. Kolodkin, Neuron 70 (2011) 281–298.
date_created: 2020-04-30T10:36:30Z
date_published: 2011-04-28T00:00:00Z
date_updated: 2024-01-31T10:14:29Z
day: '28'
doi: 10.1016/j.neuron.2011.02.050
extern: '1'
intvolume: ' 70'
issue: '2'
language:
- iso: eng
month: '04'
oa_version: None
page: 281-298
publication: Neuron
publication_identifier:
issn:
- 0896-6273
publication_status: published
publisher: Elsevier
quality_controlled: '1'
status: public
title: A combinatorial semaphorin code instructs the initial steps of sensory circuit
assembly in the Drosophila CNS
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 70
year: '2011'
...
---
_id: '7703'
abstract:
- lang: eng
text: By combining gene expression profiling with image registration, Tomer et al.
(2010) find that the mushroom body of the segmented worm Platynereis dumerilii
shares many features with the mammalian cerebral cortex. The authors propose that
the mushroom body and cortex evolved from the same structure in the common ancestor
of vertebrates and invertebrates.
article_processing_charge: No
article_type: original
author:
- first_name: Lora Beatrice Jaeger
full_name: Sweeney, Lora Beatrice Jaeger
id: 56BE8254-C4F0-11E9-8E45-0B23E6697425
last_name: Sweeney
orcid: 0000-0001-9242-5601
- first_name: Liqun
full_name: Luo, Liqun
last_name: Luo
citation:
ama: 'Sweeney LB, Luo L. ‘Fore brain: A hint of the ancestral cortex. Cell.
2010;142(5):679-681. doi:10.1016/j.cell.2010.08.024'
apa: 'Sweeney, L. B., & Luo, L. (2010). ‘Fore brain: A hint of the ancestral
cortex. Cell. Elsevier. https://doi.org/10.1016/j.cell.2010.08.024'
chicago: 'Sweeney, Lora B., and Liqun Luo. “‘Fore Brain: A Hint of the Ancestral
Cortex.” Cell. Elsevier, 2010. https://doi.org/10.1016/j.cell.2010.08.024.'
ieee: 'L. B. Sweeney and L. Luo, “‘Fore brain: A hint of the ancestral cortex,”
Cell, vol. 142, no. 5. Elsevier, pp. 679–681, 2010.'
ista: 'Sweeney LB, Luo L. 2010. ‘Fore brain: A hint of the ancestral cortex. Cell.
142(5), 679–681.'
mla: 'Sweeney, Lora B., and Liqun Luo. “‘Fore Brain: A Hint of the Ancestral Cortex.”
Cell, vol. 142, no. 5, Elsevier, 2010, pp. 679–81, doi:10.1016/j.cell.2010.08.024.'
short: L.B. Sweeney, L. Luo, Cell 142 (2010) 679–681.
date_created: 2020-04-30T10:36:52Z
date_published: 2010-09-03T00:00:00Z
date_updated: 2024-01-31T10:14:59Z
day: '03'
doi: 10.1016/j.cell.2010.08.024
extern: '1'
intvolume: ' 142'
issue: '5'
language:
- iso: eng
month: '09'
oa_version: None
page: 679-681
publication: Cell
publication_identifier:
issn:
- 0092-8674
publication_status: published
publisher: Elsevier
quality_controlled: '1'
status: public
title: '‘Fore brain: A hint of the ancestral cortex'
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 142
year: '2010'
...
---
_id: '7704'
abstract:
- lang: eng
text: Gradients of axon guidance molecules instruct the formation of continuous
neural maps, such as the retinotopic map in the vertebrate visual system. Here
we show that molecular gradients can also instruct the formation of a discrete
neural map. In the fly olfactory system, axons of 50 classes of olfactory receptor
neurons (ORNs) and dendrites of 50 classes of projection neurons (PNs) form one-to-one
connections at discrete units called glomeruli. We provide expression, loss- and
gain-of-function data to demonstrate that the levels of transmembrane Semaphorin-1a
(Sema-1a), acting cell-autonomously as a receptor or part of a receptor complex,
direct the dendritic targeting of PNs along the dorsolateral to ventromedial axis
of the antennal lobe. Sema-1a also regulates PN axon targeting in higher olfactory
centers. Thus, graded expression of Sema-1a contributes to connection specificity
from ORNs to PNs and then to higher brain centers, ensuring proper representation
of olfactory information in the brain.
article_processing_charge: No
article_type: original
author:
- first_name: Takaki
full_name: Komiyama, Takaki
last_name: Komiyama
- first_name: Lora Beatrice Jaeger
full_name: Sweeney, Lora Beatrice Jaeger
id: 56BE8254-C4F0-11E9-8E45-0B23E6697425
last_name: Sweeney
orcid: 0000-0001-9242-5601
- first_name: Oren
full_name: Schuldiner, Oren
last_name: Schuldiner
- first_name: K. Christopher
full_name: Garcia, K. Christopher
last_name: Garcia
- first_name: Liqun
full_name: Luo, Liqun
last_name: Luo
citation:
ama: Komiyama T, Sweeney LB, Schuldiner O, Garcia KC, Luo L. Graded expression of
semaphorin-1a cell-autonomously directs dendritic targeting of olfactory projection
neurons. Cell. 2007;128(2):399-410. doi:10.1016/j.cell.2006.12.028
apa: Komiyama, T., Sweeney, L. B., Schuldiner, O., Garcia, K. C., & Luo, L.
(2007). Graded expression of semaphorin-1a cell-autonomously directs dendritic
targeting of olfactory projection neurons. Cell. Elsevier. https://doi.org/10.1016/j.cell.2006.12.028
chicago: Komiyama, Takaki, Lora B. Sweeney, Oren Schuldiner, K. Christopher Garcia,
and Liqun Luo. “Graded Expression of Semaphorin-1a Cell-Autonomously Directs Dendritic
Targeting of Olfactory Projection Neurons.” Cell. Elsevier, 2007. https://doi.org/10.1016/j.cell.2006.12.028.
ieee: T. Komiyama, L. B. Sweeney, O. Schuldiner, K. C. Garcia, and L. Luo, “Graded
expression of semaphorin-1a cell-autonomously directs dendritic targeting of olfactory
projection neurons,” Cell, vol. 128, no. 2. Elsevier, pp. 399–410, 2007.
ista: Komiyama T, Sweeney LB, Schuldiner O, Garcia KC, Luo L. 2007. Graded expression
of semaphorin-1a cell-autonomously directs dendritic targeting of olfactory projection
neurons. Cell. 128(2), 399–410.
mla: Komiyama, Takaki, et al. “Graded Expression of Semaphorin-1a Cell-Autonomously
Directs Dendritic Targeting of Olfactory Projection Neurons.” Cell, vol.
128, no. 2, Elsevier, 2007, pp. 399–410, doi:10.1016/j.cell.2006.12.028.
short: T. Komiyama, L.B. Sweeney, O. Schuldiner, K.C. Garcia, L. Luo, Cell 128 (2007)
399–410.
date_created: 2020-04-30T10:37:08Z
date_published: 2007-01-26T00:00:00Z
date_updated: 2024-01-31T10:14:48Z
day: '26'
doi: 10.1016/j.cell.2006.12.028
extern: '1'
intvolume: ' 128'
issue: '2'
language:
- iso: eng
month: '01'
oa_version: None
page: 399-410
publication: Cell
publication_identifier:
issn:
- 0092-8674
publication_status: published
publisher: Elsevier
quality_controlled: '1'
status: public
title: Graded expression of semaphorin-1a cell-autonomously directs dendritic targeting
of olfactory projection neurons
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 128
year: '2007'
...
---
_id: '7705'
abstract:
- lang: eng
text: Axon-axon interactions have been implicated in neural circuit assembly, but
the underlying mechanisms are poorly understood. Here, we show that in the Drosophila
antennal lobe, early-arriving axons of olfactory receptor neurons (ORNs) from
the antenna are required for the proper targeting of late-arriving ORN axons from
the maxillary palp (MP). Semaphorin-1a is required for targeting of all MP but
only half of the antennal ORN classes examined. Sema-1a acts nonautonomously to
control ORN axon-axon interactions, in contrast to its cell-autonomous function
in olfactory projection neurons. Phenotypic and genetic interaction analyses implicate
PlexinA as the Sema-1a receptor in ORN targeting. Sema-1a on antennal ORN axons
is required for correct targeting of MP axons within the antennal lobe, while
interactions amongst MP axons facilitate their entry into the antennal lobe. We
propose that Sema-1a/PlexinA-mediated repulsion provides a mechanism by which
early-arriving ORN axons constrain the target choices of late-arriving axons.
article_processing_charge: No
article_type: original
author:
- first_name: Lora Beatrice Jaeger
full_name: Sweeney, Lora Beatrice Jaeger
id: 56BE8254-C4F0-11E9-8E45-0B23E6697425
last_name: Sweeney
orcid: 0000-0001-9242-5601
- first_name: Africa
full_name: Couto, Africa
last_name: Couto
- first_name: Ya-Hui
full_name: Chou, Ya-Hui
last_name: Chou
- first_name: Daniela
full_name: Berdnik, Daniela
last_name: Berdnik
- first_name: Barry J.
full_name: Dickson, Barry J.
last_name: Dickson
- first_name: Liqun
full_name: Luo, Liqun
last_name: Luo
- first_name: Takaki
full_name: Komiyama, Takaki
last_name: Komiyama
citation:
ama: Sweeney LB, Couto A, Chou Y-H, et al. Temporal target restriction of olfactory
receptor neurons by semaphorin-1a/plexinA-mediated axon-axon interactions. Neuron.
2007;53(2):185-200. doi:10.1016/j.neuron.2006.12.022
apa: Sweeney, L. B., Couto, A., Chou, Y.-H., Berdnik, D., Dickson, B. J., Luo, L.,
& Komiyama, T. (2007). Temporal target restriction of olfactory receptor neurons
by semaphorin-1a/plexinA-mediated axon-axon interactions. Neuron. Elsevier.
https://doi.org/10.1016/j.neuron.2006.12.022
chicago: Sweeney, Lora B., Africa Couto, Ya-Hui Chou, Daniela Berdnik, Barry J.
Dickson, Liqun Luo, and Takaki Komiyama. “Temporal Target Restriction of Olfactory
Receptor Neurons by Semaphorin-1a/PlexinA-Mediated Axon-Axon Interactions.” Neuron.
Elsevier, 2007. https://doi.org/10.1016/j.neuron.2006.12.022.
ieee: L. B. Sweeney et al., “Temporal target restriction of olfactory receptor
neurons by semaphorin-1a/plexinA-mediated axon-axon interactions,” Neuron,
vol. 53, no. 2. Elsevier, pp. 185–200, 2007.
ista: Sweeney LB, Couto A, Chou Y-H, Berdnik D, Dickson BJ, Luo L, Komiyama T. 2007.
Temporal target restriction of olfactory receptor neurons by semaphorin-1a/plexinA-mediated
axon-axon interactions. Neuron. 53(2), 185–200.
mla: Sweeney, Lora B., et al. “Temporal Target Restriction of Olfactory Receptor
Neurons by Semaphorin-1a/PlexinA-Mediated Axon-Axon Interactions.” Neuron,
vol. 53, no. 2, Elsevier, 2007, pp. 185–200, doi:10.1016/j.neuron.2006.12.022.
short: L.B. Sweeney, A. Couto, Y.-H. Chou, D. Berdnik, B.J. Dickson, L. Luo, T.
Komiyama, Neuron 53 (2007) 185–200.
date_created: 2020-04-30T10:37:24Z
date_published: 2007-01-18T00:00:00Z
date_updated: 2024-01-31T10:14:39Z
day: '18'
doi: 10.1016/j.neuron.2006.12.022
extern: '1'
intvolume: ' 53'
issue: '2'
language:
- iso: eng
month: '01'
oa_version: None
page: 185-200
publication: Neuron
publication_identifier:
issn:
- 0896-6273
publication_status: published
publisher: Elsevier
quality_controlled: '1'
status: public
title: Temporal target restriction of olfactory receptor neurons by semaphorin-1a/plexinA-mediated
axon-axon interactions
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 53
year: '2007'
...
---
_id: '7706'
abstract:
- lang: eng
text: 'The Sir2 deacetylase modulates organismal life-span in various species. However,
the molecular mechanisms by which Sir2 increases longevity are largely unknown.
We show that in mammalian cells, the Sir2 homolog SIRT1 appears to control the
cellular response to stress by regulating the FOXO family of Forkhead transcription
factors, a family of proteins that function as sensors of the insulin signaling
pathway and as regulators of organismal longevity. SIRT1 and the FOXO transcription
factor FOXO3 formed a complex in cells in response to oxidative stress, and SIRT1
deacetylated FOXO3 in vitro and within cells. SIRT1 had a dual effect on FOXO3
function: SIRT1 increased FOXO3''s ability to induce cell cycle arrest and resistance
to oxidative stress but inhibited FOXO3''s ability to induce cell death. Thus,
one way in which members of the Sir2 family of proteins may increase organismal
longevity is by tipping FOXO-dependent responses away from apoptosis and toward
stress resistance.'
article_processing_charge: No
article_type: original
author:
- first_name: Anne
full_name: Brunet, Anne
last_name: Brunet
- first_name: Lora Beatrice Jaeger
full_name: Sweeney, Lora Beatrice Jaeger
id: 56BE8254-C4F0-11E9-8E45-0B23E6697425
last_name: Sweeney
orcid: 0000-0001-9242-5601
- first_name: 'J Fitzhugh '
full_name: 'Sturgill, J Fitzhugh '
last_name: Sturgill
- first_name: Katrin
full_name: Chua, Katrin
last_name: Chua
- first_name: Paul
full_name: Greer, Paul
last_name: Greer
- first_name: Yingxi
full_name: Lin, Yingxi
last_name: Lin
- first_name: Hien
full_name: Tran, Hien
last_name: Tran
- first_name: Sarah
full_name: Ross, Sarah
last_name: Ross
- first_name: Raul
full_name: Mostoslavsky, Raul
last_name: Mostoslavsky
- first_name: Haim
full_name: Cohen, Haim
last_name: Cohen
- first_name: Linda
full_name: Hu, Linda
last_name: Hu
- first_name: Hwei-Ling
full_name: Chen, Hwei-Ling
last_name: Chen
- first_name: Mark
full_name: Jedrychowski, Mark
last_name: Jedrychowski
- first_name: Steven
full_name: Gygi, Steven
last_name: Gygi
- first_name: David
full_name: Sinclair, David
last_name: Sinclair
- first_name: Frederick
full_name: Alt, Frederick
last_name: Alt
- first_name: Michael
full_name: Greenberg, Michael
last_name: Greenberg
citation:
ama: Brunet A, Sweeney LB, Sturgill JF, et al. Stress-dependent regulation of FOXO
transcription factors by the SIRT1 deacetylase. Science. 2004;303(5666):2011-2015.
doi:10.1126/science.1094637
apa: Brunet, A., Sweeney, L. B., Sturgill, J. F., Chua, K., Greer, P., Lin, Y.,
… Greenberg, M. (2004). Stress-dependent regulation of FOXO transcription factors
by the SIRT1 deacetylase. Science. American Association for the Advancement
of Science. https://doi.org/10.1126/science.1094637
chicago: Brunet, Anne, Lora B. Sweeney, J Fitzhugh Sturgill, Katrin Chua, Paul
Greer, Yingxi Lin, Hien Tran, et al. “Stress-Dependent Regulation of FOXO Transcription
Factors by the SIRT1 Deacetylase.” Science. American Association for the
Advancement of Science, 2004. https://doi.org/10.1126/science.1094637.
ieee: A. Brunet et al., “Stress-dependent regulation of FOXO transcription
factors by the SIRT1 deacetylase,” Science, vol. 303, no. 5666. American
Association for the Advancement of Science, pp. 2011–2015, 2004.
ista: Brunet A, Sweeney LB, Sturgill JF, Chua K, Greer P, Lin Y, Tran H, Ross S,
Mostoslavsky R, Cohen H, Hu L, Chen H-L, Jedrychowski M, Gygi S, Sinclair D, Alt
F, Greenberg M. 2004. Stress-dependent regulation of FOXO transcription factors
by the SIRT1 deacetylase. Science. 303(5666), 2011–2015.
mla: Brunet, Anne, et al. “Stress-Dependent Regulation of FOXO Transcription Factors
by the SIRT1 Deacetylase.” Science, vol. 303, no. 5666, American Association
for the Advancement of Science, 2004, pp. 2011–15, doi:10.1126/science.1094637.
short: A. Brunet, L.B. Sweeney, J.F. Sturgill, K. Chua, P. Greer, Y. Lin, H. Tran,
S. Ross, R. Mostoslavsky, H. Cohen, L. Hu, H.-L. Chen, M. Jedrychowski, S. Gygi,
D. Sinclair, F. Alt, M. Greenberg, Science 303 (2004) 2011–2015.
date_created: 2020-04-30T10:37:41Z
date_published: 2004-03-26T00:00:00Z
date_updated: 2024-01-31T10:14:17Z
day: '26'
doi: 10.1126/science.1094637
extern: '1'
intvolume: ' 303'
issue: '5666'
language:
- iso: eng
month: '03'
oa_version: None
page: 2011-2015
publication: Science
publication_identifier:
issn:
- 0036-8075
- 1095-9203
publication_status: published
publisher: American Association for the Advancement of Science
quality_controlled: '1'
status: public
title: Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 303
year: '2004'
...