---
_id: '14732'
abstract:
- lang: eng
  text: 'Fragmented landscapes pose a significant threat to the persistence of species
    as they are highly susceptible to heightened risk of extinction due to the combined
    effects of genetic and demographic factors such as genetic drift and demographic
    stochasticity. This paper explores the intricate interplay between genetic load
    and extinction risk within metapopulations with a focus on understanding the impact
    of eco-evolutionary feedback mechanisms. We distinguish between two models of
    selection: soft selection, characterised by subpopulations maintaining carrying
    capacity despite load, and hard selection, where load can significantly affect
    population size. Within the soft selection framework, we investigate the impact
    of gene flow on genetic load at a single locus, while also considering the effect
    of selection strength and dominance coefficient. We subsequently build on this
    to examine how gene flow influences both population size and load under hard selection
    as well as identify critical thresholds for metapopulation persistence. Our analysis
    employs the diffusion, semi-deterministic and effective migration approximations.
    Our findings reveal that under soft selection, even modest levels of migration
    can significantly alleviate the burden of load. In sharp contrast, with hard selection,
    a much higher degree of gene flow is required to mitigate load and prevent the
    collapse of the metapopulation. Overall, this study sheds light into the crucial
    role migration plays in shaping the dynamics of genetic load and extinction risk
    in fragmented landscapes, offering valuable insights for conservation strategies
    and the preservation of diversity in a changing world.'
article_processing_charge: No
author:
- first_name: Oluwafunmilola O
  full_name: Olusanya, Oluwafunmilola O
  id: 41AD96DC-F248-11E8-B48F-1D18A9856A87
  last_name: Olusanya
  orcid: 0000-0003-1971-8314
- first_name: Kseniia
  full_name: Khudiakova, Kseniia
  id: 4E6DC800-AE37-11E9-AC72-31CAE5697425
  last_name: Khudiakova
  orcid: 0000-0002-6246-1465
- first_name: Himani
  full_name: Sachdeva, Himani
  id: 42377A0A-F248-11E8-B48F-1D18A9856A87
  last_name: Sachdeva
citation:
  ama: Olusanya OO, Khudiakova K, Sachdeva H. Genetic load, eco-evolutionary feedback
    and extinction in a metapopulation. <i>bioRxiv</i>. doi:<a href="https://doi.org/10.1101/2023.12.02.569702">10.1101/2023.12.02.569702</a>
  apa: Olusanya, O. O., Khudiakova, K., &#38; Sachdeva, H. (n.d.). Genetic load, eco-evolutionary
    feedback and extinction in a metapopulation. <i>bioRxiv</i>. <a href="https://doi.org/10.1101/2023.12.02.569702">https://doi.org/10.1101/2023.12.02.569702</a>
  chicago: Olusanya, Oluwafunmilola O, Kseniia Khudiakova, and Himani Sachdeva. “Genetic
    Load, Eco-Evolutionary Feedback and Extinction in a Metapopulation.” <i>BioRxiv</i>,
    n.d. <a href="https://doi.org/10.1101/2023.12.02.569702">https://doi.org/10.1101/2023.12.02.569702</a>.
  ieee: O. O. Olusanya, K. Khudiakova, and H. Sachdeva, “Genetic load, eco-evolutionary
    feedback and extinction in a metapopulation,” <i>bioRxiv</i>. .
  ista: Olusanya OO, Khudiakova K, Sachdeva H. Genetic load, eco-evolutionary feedback
    and extinction in a metapopulation. bioRxiv, <a href="https://doi.org/10.1101/2023.12.02.569702">10.1101/2023.12.02.569702</a>.
  mla: Olusanya, Oluwafunmilola O., et al. “Genetic Load, Eco-Evolutionary Feedback
    and Extinction in a Metapopulation.” <i>BioRxiv</i>, doi:<a href="https://doi.org/10.1101/2023.12.02.569702">10.1101/2023.12.02.569702</a>.
  short: O.O. Olusanya, K. Khudiakova, H. Sachdeva, BioRxiv (n.d.).
date_created: 2024-01-04T09:35:54Z
date_published: 2023-12-04T00:00:00Z
date_updated: 2025-05-26T09:05:10Z
day: '04'
department:
- _id: NiBa
- _id: JaMa
doi: 10.1101/2023.12.02.569702
language:
- iso: eng
license: https://creativecommons.org/licenses/by-nc-nd/4.0/
main_file_link:
- open_access: '1'
  url: https://www.biorxiv.org/content/10.1101/2023.12.02.569702v1
month: '12'
oa: 1
oa_version: Preprint
project:
- _id: c08d3278-5a5b-11eb-8a69-fdb09b55f4b8
  grant_number: P32896
  name: Causes and consequences of population fragmentation
- _id: 34d33d68-11ca-11ed-8bc3-ec13763c0ca8
  grant_number: '26293'
  name: The impact of deleterious mutations on small populations
- _id: 34c872fe-11ca-11ed-8bc3-8534b82131e6
  grant_number: '26380'
  name: Polygenic Adaptation in a Metapopulation
publication: bioRxiv
publication_status: submitted
related_material:
  record:
  - id: '14711'
    relation: dissertation_contains
    status: public
status: public
title: Genetic load, eco-evolutionary feedback and extinction in a metapopulation
tmp:
  image: /images/cc_by_nc_nd.png
  legal_code_url: https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode
  name: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
    (CC BY-NC-ND 4.0)
  short: CC BY-NC-ND (4.0)
type: preprint
user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
year: '2023'
...
---
_id: '12521'
abstract:
- lang: eng
  text: Differentiated X chromosomes are expected to have higher rates of adaptive
    divergence than autosomes, if new beneficial mutations are recessive (the “faster-X
    effect”), largely because these mutations are immediately exposed to selection
    in males. The evolution of X chromosomes after they stop recombining in males,
    but before they become hemizygous, has not been well explored theoretically. We
    use the diffusion approximation to infer substitution rates of beneficial and
    deleterious mutations under such a scenario. Our results show that selection is
    less efficient on diploid X loci than on autosomal and hemizygous X loci under
    a wide range of parameters. This “slower-X” effect is stronger for genes affecting
    primarily (or only) male fitness, and for sexually antagonistic genes. These unusual
    dynamics suggest that some of the peculiar features of X chromosomes, such as
    the differential accumulation of genes with sex-specific functions, may start
    arising earlier than previously appreciated.
acknowledgement: We thank the Vicoso and Barton groups and ISTA Scientific Computing
  Unit. We also thank two anonymous reviewers for their valuable comments. This work
  was supported by the European Research Council under the European Union’s Horizon
  2020 research and innovation program (grant agreements no. 715257 and no. 716117).
article_number: qrac004
article_processing_charge: Yes (via OA deal)
article_type: original
author:
- first_name: Andrea
  full_name: Mrnjavac, Andrea
  id: 353FAC84-AE61-11E9-8BFC-00D3E5697425
  last_name: Mrnjavac
- first_name: Kseniia
  full_name: Khudiakova, Kseniia
  id: 4E6DC800-AE37-11E9-AC72-31CAE5697425
  last_name: Khudiakova
  orcid: 0000-0002-6246-1465
- first_name: Nicholas H
  full_name: Barton, Nicholas H
  id: 4880FE40-F248-11E8-B48F-1D18A9856A87
  last_name: Barton
  orcid: 0000-0002-8548-5240
- first_name: Beatriz
  full_name: Vicoso, Beatriz
  id: 49E1C5C6-F248-11E8-B48F-1D18A9856A87
  last_name: Vicoso
  orcid: 0000-0002-4579-8306
citation:
  ama: 'Mrnjavac A, Khudiakova K, Barton NH, Vicoso B. Slower-X: Reduced efficiency
    of selection in the early stages of X chromosome evolution. <i>Evolution Letters</i>.
    2023;7(1). doi:<a href="https://doi.org/10.1093/evlett/qrac004">10.1093/evlett/qrac004</a>'
  apa: 'Mrnjavac, A., Khudiakova, K., Barton, N. H., &#38; Vicoso, B. (2023). Slower-X:
    Reduced efficiency of selection in the early stages of X chromosome evolution.
    <i>Evolution Letters</i>. Oxford University Press. <a href="https://doi.org/10.1093/evlett/qrac004">https://doi.org/10.1093/evlett/qrac004</a>'
  chicago: 'Mrnjavac, Andrea, Kseniia Khudiakova, Nicholas H Barton, and Beatriz Vicoso.
    “Slower-X: Reduced Efficiency of Selection in the Early Stages of X Chromosome
    Evolution.” <i>Evolution Letters</i>. Oxford University Press, 2023. <a href="https://doi.org/10.1093/evlett/qrac004">https://doi.org/10.1093/evlett/qrac004</a>.'
  ieee: 'A. Mrnjavac, K. Khudiakova, N. H. Barton, and B. Vicoso, “Slower-X: Reduced
    efficiency of selection in the early stages of X chromosome evolution,” <i>Evolution
    Letters</i>, vol. 7, no. 1. Oxford University Press, 2023.'
  ista: 'Mrnjavac A, Khudiakova K, Barton NH, Vicoso B. 2023. Slower-X: Reduced efficiency
    of selection in the early stages of X chromosome evolution. Evolution Letters.
    7(1), qrac004.'
  mla: 'Mrnjavac, Andrea, et al. “Slower-X: Reduced Efficiency of Selection in the
    Early Stages of X Chromosome Evolution.” <i>Evolution Letters</i>, vol. 7, no.
    1, qrac004, Oxford University Press, 2023, doi:<a href="https://doi.org/10.1093/evlett/qrac004">10.1093/evlett/qrac004</a>.'
  short: A. Mrnjavac, K. Khudiakova, N.H. Barton, B. Vicoso, Evolution Letters 7 (2023).
date_created: 2023-02-06T13:59:12Z
date_published: 2023-02-01T00:00:00Z
date_updated: 2023-08-16T11:44:32Z
day: '01'
ddc:
- '570'
department:
- _id: GradSch
- _id: BeVi
doi: 10.1093/evlett/qrac004
ec_funded: 1
external_id:
  isi:
  - '001021692200001'
  pmid:
  - '37065438'
file:
- access_level: open_access
  checksum: a240a041cb9b9b7c8ba93a4706674a3f
  content_type: application/pdf
  creator: dernst
  date_created: 2023-08-16T11:43:33Z
  date_updated: 2023-08-16T11:43:33Z
  file_id: '14068'
  file_name: 2023_EvLetters_Mrnjavac.pdf
  file_size: 2592189
  relation: main_file
  success: 1
file_date_updated: 2023-08-16T11:43:33Z
has_accepted_license: '1'
intvolume: '         7'
isi: 1
issue: '1'
keyword:
- Genetics
- Ecology
- Evolution
- Behavior and Systematics
language:
- iso: eng
month: '02'
oa: 1
oa_version: Published Version
pmid: 1
project:
- _id: 256E75B8-B435-11E9-9278-68D0E5697425
  call_identifier: H2020
  grant_number: '716117'
  name: Optimal Transport and Stochastic Dynamics
- _id: 250BDE62-B435-11E9-9278-68D0E5697425
  call_identifier: H2020
  grant_number: '715257'
  name: Prevalence and Influence of Sexual Antagonism on Genome Evolution
publication: Evolution Letters
publication_identifier:
  issn:
  - 2056-3744
publication_status: published
publisher: Oxford University Press
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Slower-X: Reduced efficiency of selection in the early stages of X chromosome
  evolution'
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 7
year: '2023'
...
---
_id: '11447'
abstract:
- lang: eng
  text: Empirical essays of fitness landscapes suggest that they may be rugged, that
    is having multiple fitness peaks. Such fitness landscapes, those that have multiple
    peaks, necessarily have special local structures, called reciprocal sign epistasis
    (Poelwijk et al. in J Theor Biol 272:141–144, 2011). Here, we investigate the
    quantitative relationship between the number of fitness peaks and the number of
    reciprocal sign epistatic interactions. Previously, it has been shown (Poelwijk
    et al. in J Theor Biol 272:141–144, 2011) that pairwise reciprocal sign epistasis
    is a necessary but not sufficient condition for the existence of multiple peaks.
    Applying discrete Morse theory, which to our knowledge has never been used in
    this context, we extend this result by giving the minimal number of reciprocal
    sign epistatic interactions required to create a given number of peaks.
acknowledgement: We are grateful to Herbert Edelsbrunner and Jeferson Zapata for helpful
  discussions. Open access funding provided by Austrian Science Fund (FWF). Partially
  supported by the ERC Consolidator (771209–CharFL) and the FWF Austrian Science Fund
  (I5127-B) grants to FAK.
article_number: '74'
article_processing_charge: Yes (via OA deal)
article_type: original
author:
- first_name: Raimundo J
  full_name: Saona Urmeneta, Raimundo J
  id: BD1DF4C4-D767-11E9-B658-BC13E6697425
  last_name: Saona Urmeneta
  orcid: 0000-0001-5103-038X
- first_name: Fyodor
  full_name: Kondrashov, Fyodor
  id: 44FDEF62-F248-11E8-B48F-1D18A9856A87
  last_name: Kondrashov
  orcid: 0000-0001-8243-4694
- first_name: Kseniia
  full_name: Khudiakova, Kseniia
  id: 4E6DC800-AE37-11E9-AC72-31CAE5697425
  last_name: Khudiakova
  orcid: 0000-0002-6246-1465
citation:
  ama: Saona Urmeneta RJ, Kondrashov F, Khudiakova K. Relation between the number
    of peaks and the number of reciprocal sign epistatic interactions. <i>Bulletin
    of Mathematical Biology</i>. 2022;84(8). doi:<a href="https://doi.org/10.1007/s11538-022-01029-z">10.1007/s11538-022-01029-z</a>
  apa: Saona Urmeneta, R. J., Kondrashov, F., &#38; Khudiakova, K. (2022). Relation
    between the number of peaks and the number of reciprocal sign epistatic interactions.
    <i>Bulletin of Mathematical Biology</i>. Springer Nature. <a href="https://doi.org/10.1007/s11538-022-01029-z">https://doi.org/10.1007/s11538-022-01029-z</a>
  chicago: Saona Urmeneta, Raimundo J, Fyodor Kondrashov, and Kseniia Khudiakova.
    “Relation between the Number of Peaks and the Number of Reciprocal Sign Epistatic
    Interactions.” <i>Bulletin of Mathematical Biology</i>. Springer Nature, 2022.
    <a href="https://doi.org/10.1007/s11538-022-01029-z">https://doi.org/10.1007/s11538-022-01029-z</a>.
  ieee: R. J. Saona Urmeneta, F. Kondrashov, and K. Khudiakova, “Relation between
    the number of peaks and the number of reciprocal sign epistatic interactions,”
    <i>Bulletin of Mathematical Biology</i>, vol. 84, no. 8. Springer Nature, 2022.
  ista: Saona Urmeneta RJ, Kondrashov F, Khudiakova K. 2022. Relation between the
    number of peaks and the number of reciprocal sign epistatic interactions. Bulletin
    of Mathematical Biology. 84(8), 74.
  mla: Saona Urmeneta, Raimundo J., et al. “Relation between the Number of Peaks and
    the Number of Reciprocal Sign Epistatic Interactions.” <i>Bulletin of Mathematical
    Biology</i>, vol. 84, no. 8, 74, Springer Nature, 2022, doi:<a href="https://doi.org/10.1007/s11538-022-01029-z">10.1007/s11538-022-01029-z</a>.
  short: R.J. Saona Urmeneta, F. Kondrashov, K. Khudiakova, Bulletin of Mathematical
    Biology 84 (2022).
date_created: 2022-06-17T16:16:15Z
date_published: 2022-06-17T00:00:00Z
date_updated: 2023-08-03T07:20:53Z
day: '17'
ddc:
- '510'
- '570'
department:
- _id: GradSch
- _id: NiBa
- _id: JaMa
doi: 10.1007/s11538-022-01029-z
ec_funded: 1
external_id:
  isi:
  - '000812509800001'
file:
- access_level: open_access
  checksum: 05a1fe7d10914a00c2bca9b447993a65
  content_type: application/pdf
  creator: dernst
  date_created: 2022-06-20T07:51:32Z
  date_updated: 2022-06-20T07:51:32Z
  file_id: '11455'
  file_name: 2022_BulletinMathBiology_Saona.pdf
  file_size: 463025
  relation: main_file
  success: 1
file_date_updated: 2022-06-20T07:51:32Z
has_accepted_license: '1'
intvolume: '        84'
isi: 1
issue: '8'
keyword:
- Computational Theory and Mathematics
- General Agricultural and Biological Sciences
- Pharmacology
- General Environmental Science
- General Biochemistry
- Genetics and Molecular Biology
- General Mathematics
- Immunology
- General Neuroscience
language:
- iso: eng
month: '06'
oa: 1
oa_version: Published Version
project:
- _id: 26580278-B435-11E9-9278-68D0E5697425
  call_identifier: H2020
  grant_number: '771209'
  name: Characterizing the fitness landscape on population and global scales
- _id: c098eddd-5a5b-11eb-8a69-abe27170a68f
  grant_number: I05127
  name: Evolutionary analysis of gene regulation
publication: Bulletin of Mathematical Biology
publication_identifier:
  eissn:
  - 1522-9602
  issn:
  - 0092-8240
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
related_material:
  link:
  - relation: erratum
    url: https://doi.org/10.1007/s11538-022-01118-z
scopus_import: '1'
status: public
title: Relation between the number of peaks and the number of reciprocal sign epistatic
  interactions
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 84
year: '2022'
...
---
_id: '9387'
abstract:
- lang: eng
  text: We report the complete analysis of a deterministic model of deleterious mutations
    and negative selection against them at two haploid loci without recombination.
    As long as mutation is a weaker force than selection, mutant alleles remain rare
    at the only stable equilibrium, and otherwise, a variety of dynamics are possible.
    If the mutation-free genotype is absent, generally the only stable equilibrium
    is the one that corresponds to fixation of the mutant allele at the locus where
    it is less deleterious. This result suggests that fixation of a deleterious allele
    that follows a click of the Muller’s ratchet is governed by natural selection,
    instead of random drift.
acknowledgement: This work was supported by the Russian Science Foundation grant N
  16-14-10173.
article_number: '110729'
article_processing_charge: No
article_type: original
author:
- first_name: Kseniia
  full_name: Khudiakova, Kseniia
  id: 4E6DC800-AE37-11E9-AC72-31CAE5697425
  last_name: Khudiakova
  orcid: 0000-0002-6246-1465
- first_name: Tatiana Yu.
  full_name: Neretina, Tatiana Yu.
  last_name: Neretina
- first_name: Alexey S.
  full_name: Kondrashov, Alexey S.
  last_name: Kondrashov
citation:
  ama: Khudiakova K, Neretina TY, Kondrashov AS. Two linked loci under mutation-selection
    balance and Muller’s ratchet. <i>Journal of Theoretical Biology</i>. 2021;524.
    doi:<a href="https://doi.org/10.1016/j.jtbi.2021.110729">10.1016/j.jtbi.2021.110729</a>
  apa: Khudiakova, K., Neretina, T. Y., &#38; Kondrashov, A. S. (2021). Two linked
    loci under mutation-selection balance and Muller’s ratchet. <i>Journal of Theoretical
    Biology</i>. Elsevier . <a href="https://doi.org/10.1016/j.jtbi.2021.110729">https://doi.org/10.1016/j.jtbi.2021.110729</a>
  chicago: Khudiakova, Kseniia, Tatiana Yu. Neretina, and Alexey S. Kondrashov. “Two
    Linked Loci under Mutation-Selection Balance and Muller’s Ratchet.” <i>Journal
    of Theoretical Biology</i>. Elsevier , 2021. <a href="https://doi.org/10.1016/j.jtbi.2021.110729">https://doi.org/10.1016/j.jtbi.2021.110729</a>.
  ieee: K. Khudiakova, T. Y. Neretina, and A. S. Kondrashov, “Two linked loci under
    mutation-selection balance and Muller’s ratchet,” <i>Journal of Theoretical Biology</i>,
    vol. 524. Elsevier , 2021.
  ista: Khudiakova K, Neretina TY, Kondrashov AS. 2021. Two linked loci under mutation-selection
    balance and Muller’s ratchet. Journal of Theoretical Biology. 524, 110729.
  mla: Khudiakova, Kseniia, et al. “Two Linked Loci under Mutation-Selection Balance
    and Muller’s Ratchet.” <i>Journal of Theoretical Biology</i>, vol. 524, 110729,
    Elsevier , 2021, doi:<a href="https://doi.org/10.1016/j.jtbi.2021.110729">10.1016/j.jtbi.2021.110729</a>.
  short: K. Khudiakova, T.Y. Neretina, A.S. Kondrashov, Journal of Theoretical Biology
    524 (2021).
date_created: 2021-05-12T05:58:42Z
date_published: 2021-04-24T00:00:00Z
date_updated: 2023-08-08T13:32:40Z
day: '24'
department:
- _id: GradSch
doi: 10.1016/j.jtbi.2021.110729
external_id:
  isi:
  - '000659161500002'
intvolume: '       524'
isi: 1
keyword:
- General Biochemistry
- Genetics and Molecular Biology
- Modelling and Simulation
- Statistics and Probability
- General Immunology and Microbiology
- Applied Mathematics
- General Agricultural and Biological Sciences
- General Medicine
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://www.biorxiv.org/content/10.1101/477489v1
month: '04'
oa: 1
oa_version: Preprint
publication: Journal of Theoretical Biology
publication_identifier:
  issn:
  - 0022-5193
publication_status: published
publisher: 'Elsevier '
quality_controlled: '1'
status: public
title: Two linked loci under mutation-selection balance and Muller’s ratchet
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 524
year: '2021'
...