---
_id: '1067'
abstract:
- lang: eng
  text: Embryo morphogenesis relies on highly coordinated movements of different tissues.
    However, remarkably little is known about how tissues coordinate their movements
    to shape the embryo. In zebrafish embryogenesis, coordinated tissue movements
    first become apparent during “doming,” when the blastoderm begins to spread over
    the yolk sac, a process involving coordinated epithelial surface cell layer expansion
    and mesenchymal deep cell intercalations. Here, we find that active surface cell
    expansion represents the key process coordinating tissue movements during doming.
    By using a combination of theory and experiments, we show that epithelial surface
    cells not only trigger blastoderm expansion by reducing tissue surface tension,
    but also drive blastoderm thinning by inducing tissue contraction through radial
    deep cell intercalations. Thus, coordinated tissue expansion and thinning during
    doming relies on surface cells simultaneously controlling tissue surface tension
    and radial tissue contraction.
acknowledged_ssus:
- _id: PreCl
article_processing_charge: No
author:
- first_name: Hitoshi
  full_name: Morita, Hitoshi
  id: 4C6E54C6-F248-11E8-B48F-1D18A9856A87
  last_name: Morita
- first_name: Silvia
  full_name: Grigolon, Silvia
  last_name: Grigolon
- first_name: Martin
  full_name: Bock, Martin
  last_name: Bock
- first_name: Gabriel
  full_name: Krens, Gabriel
  id: 2B819732-F248-11E8-B48F-1D18A9856A87
  last_name: Krens
  orcid: 0000-0003-4761-5996
- first_name: Guillaume
  full_name: Salbreux, Guillaume
  last_name: Salbreux
- first_name: Carl-Philipp J
  full_name: Heisenberg, Carl-Philipp J
  id: 39427864-F248-11E8-B48F-1D18A9856A87
  last_name: Heisenberg
  orcid: 0000-0002-0912-4566
citation:
  ama: Morita H, Grigolon S, Bock M, Krens G, Salbreux G, Heisenberg C-PJ. The physical
    basis of coordinated tissue spreading in zebrafish gastrulation. <i>Developmental
    Cell</i>. 2017;40(4):354-366. doi:<a href="https://doi.org/10.1016/j.devcel.2017.01.010">10.1016/j.devcel.2017.01.010</a>
  apa: Morita, H., Grigolon, S., Bock, M., Krens, G., Salbreux, G., &#38; Heisenberg,
    C.-P. J. (2017). The physical basis of coordinated tissue spreading in zebrafish
    gastrulation. <i>Developmental Cell</i>. Cell Press. <a href="https://doi.org/10.1016/j.devcel.2017.01.010">https://doi.org/10.1016/j.devcel.2017.01.010</a>
  chicago: Morita, Hitoshi, Silvia Grigolon, Martin Bock, Gabriel Krens, Guillaume
    Salbreux, and Carl-Philipp J Heisenberg. “The Physical Basis of Coordinated Tissue
    Spreading in Zebrafish Gastrulation.” <i>Developmental Cell</i>. Cell Press, 2017.
    <a href="https://doi.org/10.1016/j.devcel.2017.01.010">https://doi.org/10.1016/j.devcel.2017.01.010</a>.
  ieee: H. Morita, S. Grigolon, M. Bock, G. Krens, G. Salbreux, and C.-P. J. Heisenberg,
    “The physical basis of coordinated tissue spreading in zebrafish gastrulation,”
    <i>Developmental Cell</i>, vol. 40, no. 4. Cell Press, pp. 354–366, 2017.
  ista: Morita H, Grigolon S, Bock M, Krens G, Salbreux G, Heisenberg C-PJ. 2017.
    The physical basis of coordinated tissue spreading in zebrafish gastrulation.
    Developmental Cell. 40(4), 354–366.
  mla: Morita, Hitoshi, et al. “The Physical Basis of Coordinated Tissue Spreading
    in Zebrafish Gastrulation.” <i>Developmental Cell</i>, vol. 40, no. 4, Cell Press,
    2017, pp. 354–66, doi:<a href="https://doi.org/10.1016/j.devcel.2017.01.010">10.1016/j.devcel.2017.01.010</a>.
  short: H. Morita, S. Grigolon, M. Bock, G. Krens, G. Salbreux, C.-P.J. Heisenberg,
    Developmental Cell 40 (2017) 354–366.
date_created: 2018-12-11T11:49:58Z
date_published: 2017-02-27T00:00:00Z
date_updated: 2023-09-20T12:06:27Z
day: '27'
ddc:
- '572'
- '597'
department:
- _id: CaHe
doi: 10.1016/j.devcel.2017.01.010
ec_funded: 1
external_id:
  isi:
  - '000395368300007'
file:
- access_level: open_access
  content_type: application/pdf
  creator: system
  date_created: 2018-12-12T10:10:57Z
  date_updated: 2018-12-12T10:10:57Z
  file_id: '4849'
  file_name: IST-2017-869-v1+1_1-s2.0-S1534580717300370-main.pdf
  file_size: 6866187
  relation: main_file
file_date_updated: 2018-12-12T10:10:57Z
has_accepted_license: '1'
intvolume: '        40'
isi: 1
issue: '4'
language:
- iso: eng
license: https://creativecommons.org/licenses/by/4.0/
month: '02'
oa: 1
oa_version: Published Version
page: 354 - 366
project:
- _id: 2524F500-B435-11E9-9278-68D0E5697425
  call_identifier: FP7
  grant_number: '201439'
  name: Developing High-Throughput Bioassays for Human Cancers in Zebrafish
publication: Developmental Cell
publication_identifier:
  issn:
  - '15345807'
publication_status: published
publisher: Cell Press
publist_id: '6320'
pubrep_id: '869'
quality_controlled: '1'
scopus_import: '1'
status: public
title: The physical basis of coordinated tissue spreading in zebrafish gastrulation
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 40
year: '2017'
...
---
_id: '1817'
abstract:
- lang: eng
  text: 'Vertebrates have a unique 3D body shape in which correct tissue and organ
    shape and alignment are essential for function. For example, vision requires the
    lens to be centred in the eye cup which must in turn be correctly positioned in
    the head. Tissue morphogenesis depends on force generation, force transmission
    through the tissue, and response of tissues and extracellular matrix to force.
    Although a century ago D''Arcy Thompson postulated that terrestrial animal body
    shapes are conditioned by gravity, there has been no animal model directly demonstrating
    how the aforementioned mechano-morphogenetic processes are coordinated to generate
    a body shape that withstands gravity. Here we report a unique medaka fish (Oryzias
    latipes) mutant, hirame (hir), which is sensitive to deformation by gravity. hir
    embryos display a markedly flattened body caused by mutation of YAP, a nuclear
    executor of Hippo signalling that regulates organ size. We show that actomyosin-mediated
    tissue tension is reduced in hir embryos, leading to tissue flattening and tissue
    misalignment, both of which contribute to body flattening. By analysing YAP function
    in 3D spheroids of human cells, we identify the Rho GTPase activating protein
    ARHGAP18 as an effector of YAP in controlling tissue tension. Together, these
    findings reveal a previously unrecognised function of YAP in regulating tissue
    shape and alignment required for proper 3D body shape. Understanding this morphogenetic
    function of YAP could facilitate the use of embryonic stem cells to generate complex
    organs requiring correct alignment of multiple tissues. '
author:
- first_name: Sean
  full_name: Porazinski, Sean
  last_name: Porazinski
- first_name: Huijia
  full_name: Wang, Huijia
  last_name: Wang
- first_name: Yoichi
  full_name: Asaoka, Yoichi
  last_name: Asaoka
- first_name: Martin
  full_name: Behrndt, Martin
  id: 3ECECA3A-F248-11E8-B48F-1D18A9856A87
  last_name: Behrndt
- first_name: Tatsuo
  full_name: Miyamoto, Tatsuo
  last_name: Miyamoto
- first_name: Hitoshi
  full_name: Morita, Hitoshi
  id: 4C6E54C6-F248-11E8-B48F-1D18A9856A87
  last_name: Morita
- first_name: Shoji
  full_name: Hata, Shoji
  last_name: Hata
- first_name: Takashi
  full_name: Sasaki, Takashi
  last_name: Sasaki
- first_name: Gabriel
  full_name: Krens, Gabriel
  id: 2B819732-F248-11E8-B48F-1D18A9856A87
  last_name: Krens
  orcid: 0000-0003-4761-5996
- first_name: Yumi
  full_name: Osada, Yumi
  last_name: Osada
- first_name: Satoshi
  full_name: Asaka, Satoshi
  last_name: Asaka
- first_name: Akihiro
  full_name: Momoi, Akihiro
  last_name: Momoi
- first_name: Sarah
  full_name: Linton, Sarah
  last_name: Linton
- first_name: Joel
  full_name: Miesfeld, Joel
  last_name: Miesfeld
- first_name: Brian
  full_name: Link, Brian
  last_name: Link
- first_name: Takeshi
  full_name: Senga, Takeshi
  last_name: Senga
- first_name: Atahualpa
  full_name: Castillo Morales, Atahualpa
  last_name: Castillo Morales
- first_name: Araxi
  full_name: Urrutia, Araxi
  last_name: Urrutia
- first_name: Nobuyoshi
  full_name: Shimizu, Nobuyoshi
  last_name: Shimizu
- first_name: Hideaki
  full_name: Nagase, Hideaki
  last_name: Nagase
- first_name: Shinya
  full_name: Matsuura, Shinya
  last_name: Matsuura
- first_name: Stefan
  full_name: Bagby, Stefan
  last_name: Bagby
- first_name: Hisato
  full_name: Kondoh, Hisato
  last_name: Kondoh
- first_name: Hiroshi
  full_name: Nishina, Hiroshi
  last_name: Nishina
- first_name: Carl-Philipp J
  full_name: Heisenberg, Carl-Philipp J
  id: 39427864-F248-11E8-B48F-1D18A9856A87
  last_name: Heisenberg
  orcid: 0000-0002-0912-4566
- first_name: Makoto
  full_name: Furutani Seiki, Makoto
  last_name: Furutani Seiki
citation:
  ama: Porazinski S, Wang H, Asaoka Y, et al. YAP is essential for tissue tension
    to ensure vertebrate 3D body shape. <i>Nature</i>. 2015;521(7551):217-221. doi:<a
    href="https://doi.org/10.1038/nature14215">10.1038/nature14215</a>
  apa: Porazinski, S., Wang, H., Asaoka, Y., Behrndt, M., Miyamoto, T., Morita, H.,
    … Furutani Seiki, M. (2015). YAP is essential for tissue tension to ensure vertebrate
    3D body shape. <i>Nature</i>. Nature Publishing Group. <a href="https://doi.org/10.1038/nature14215">https://doi.org/10.1038/nature14215</a>
  chicago: Porazinski, Sean, Huijia Wang, Yoichi Asaoka, Martin Behrndt, Tatsuo Miyamoto,
    Hitoshi Morita, Shoji Hata, et al. “YAP Is Essential for Tissue Tension to Ensure
    Vertebrate 3D Body Shape.” <i>Nature</i>. Nature Publishing Group, 2015. <a href="https://doi.org/10.1038/nature14215">https://doi.org/10.1038/nature14215</a>.
  ieee: S. Porazinski <i>et al.</i>, “YAP is essential for tissue tension to ensure
    vertebrate 3D body shape,” <i>Nature</i>, vol. 521, no. 7551. Nature Publishing
    Group, pp. 217–221, 2015.
  ista: Porazinski S, Wang H, Asaoka Y, Behrndt M, Miyamoto T, Morita H, Hata S, Sasaki
    T, Krens G, Osada Y, Asaka S, Momoi A, Linton S, Miesfeld J, Link B, Senga T,
    Castillo Morales A, Urrutia A, Shimizu N, Nagase H, Matsuura S, Bagby S, Kondoh
    H, Nishina H, Heisenberg C-PJ, Furutani Seiki M. 2015. YAP is essential for tissue
    tension to ensure vertebrate 3D body shape. Nature. 521(7551), 217–221.
  mla: Porazinski, Sean, et al. “YAP Is Essential for Tissue Tension to Ensure Vertebrate
    3D Body Shape.” <i>Nature</i>, vol. 521, no. 7551, Nature Publishing Group, 2015,
    pp. 217–21, doi:<a href="https://doi.org/10.1038/nature14215">10.1038/nature14215</a>.
  short: S. Porazinski, H. Wang, Y. Asaoka, M. Behrndt, T. Miyamoto, H. Morita, S.
    Hata, T. Sasaki, G. Krens, Y. Osada, S. Asaka, A. Momoi, S. Linton, J. Miesfeld,
    B. Link, T. Senga, A. Castillo Morales, A. Urrutia, N. Shimizu, H. Nagase, S.
    Matsuura, S. Bagby, H. Kondoh, H. Nishina, C.-P.J. Heisenberg, M. Furutani Seiki,
    Nature 521 (2015) 217–221.
date_created: 2018-12-11T11:54:10Z
date_published: 2015-03-16T00:00:00Z
date_updated: 2021-01-12T06:53:23Z
day: '16'
department:
- _id: CaHe
doi: 10.1038/nature14215
external_id:
  pmid:
  - '25778702'
intvolume: '       521'
issue: '7551'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4720436/
month: '03'
oa: 1
oa_version: Submitted Version
page: 217 - 221
pmid: 1
publication: Nature
publication_status: published
publisher: Nature Publishing Group
publist_id: '5289'
quality_controlled: '1'
scopus_import: 1
status: public
title: YAP is essential for tissue tension to ensure vertebrate 3D body shape
type: journal_article
user_id: 2EBD1598-F248-11E8-B48F-1D18A9856A87
volume: 521
year: '2015'
...
---
_id: '1537'
abstract:
- lang: eng
  text: 3D amoeboid cell migration is central to many developmental and disease-related
    processes such as cancer metastasis. Here, we identify a unique prototypic amoeboid
    cell migration mode in early zebrafish embryos, termed stable-bleb migration.
    Stable-bleb cells display an invariant polarized balloon-like shape with exceptional
    migration speed and persistence. Progenitor cells can be reversibly transformed
    into stable-bleb cells irrespective of their primary fate and motile characteristics
    by increasing myosin II activity through biochemical or mechanical stimuli. Using
    a combination of theory and experiments, we show that, in stable-bleb cells, cortical
    contractility fluctuations trigger a stochastic switch into amoeboid motility,
    and a positive feedback between cortical flows and gradients in contractility
    maintains stable-bleb cell polarization. We further show that rearward cortical
    flows drive stable-bleb cell migration in various adhesive and non-adhesive environments,
    unraveling a highly versatile amoeboid migration phenotype.
acknowledged_ssus:
- _id: SSU
acknowledgement: 'We would like to thank R. Hausschild and E. Papusheva for technical
  assistance and the service facilities at the IST Austria for continuous support.
  The caRhoA plasmid was a kind gift of T. Kudoh and A. Takesono. We thank M. Piel
  and E. Paluch for exchanging unpublished data. '
author:
- first_name: Verena
  full_name: Ruprecht, Verena
  id: 4D71A03A-F248-11E8-B48F-1D18A9856A87
  last_name: Ruprecht
  orcid: 0000-0003-4088-8633
- first_name: Stefan
  full_name: Wieser, Stefan
  id: 355AA5A0-F248-11E8-B48F-1D18A9856A87
  last_name: Wieser
  orcid: 0000-0002-2670-2217
- first_name: Andrew
  full_name: Callan Jones, Andrew
  last_name: Callan Jones
- first_name: Michael
  full_name: Smutny, Michael
  id: 3FE6E4E8-F248-11E8-B48F-1D18A9856A87
  last_name: Smutny
  orcid: 0000-0002-5920-9090
- first_name: Hitoshi
  full_name: Morita, Hitoshi
  id: 4C6E54C6-F248-11E8-B48F-1D18A9856A87
  last_name: Morita
- first_name: Keisuke
  full_name: Sako, Keisuke
  id: 3BED66BE-F248-11E8-B48F-1D18A9856A87
  last_name: Sako
  orcid: 0000-0002-6453-8075
- first_name: Vanessa
  full_name: Barone, Vanessa
  id: 419EECCC-F248-11E8-B48F-1D18A9856A87
  last_name: Barone
  orcid: 0000-0003-2676-3367
- first_name: Monika
  full_name: Ritsch Marte, Monika
  last_name: Ritsch Marte
- first_name: Michael K
  full_name: Sixt, Michael K
  id: 41E9FBEA-F248-11E8-B48F-1D18A9856A87
  last_name: Sixt
  orcid: 0000-0002-6620-9179
- first_name: Raphaël
  full_name: Voituriez, Raphaël
  last_name: Voituriez
- first_name: Carl-Philipp J
  full_name: Heisenberg, Carl-Philipp J
  id: 39427864-F248-11E8-B48F-1D18A9856A87
  last_name: Heisenberg
  orcid: 0000-0002-0912-4566
citation:
  ama: Ruprecht V, Wieser S, Callan Jones A, et al. Cortical contractility triggers
    a stochastic switch to fast amoeboid cell motility. <i>Cell</i>. 2015;160(4):673-685.
    doi:<a href="https://doi.org/10.1016/j.cell.2015.01.008">10.1016/j.cell.2015.01.008</a>
  apa: Ruprecht, V., Wieser, S., Callan Jones, A., Smutny, M., Morita, H., Sako, K.,
    … Heisenberg, C.-P. J. (2015). Cortical contractility triggers a stochastic switch
    to fast amoeboid cell motility. <i>Cell</i>. Cell Press. <a href="https://doi.org/10.1016/j.cell.2015.01.008">https://doi.org/10.1016/j.cell.2015.01.008</a>
  chicago: Ruprecht, Verena, Stefan Wieser, Andrew Callan Jones, Michael Smutny, Hitoshi
    Morita, Keisuke Sako, Vanessa Barone, et al. “Cortical Contractility Triggers
    a Stochastic Switch to Fast Amoeboid Cell Motility.” <i>Cell</i>. Cell Press,
    2015. <a href="https://doi.org/10.1016/j.cell.2015.01.008">https://doi.org/10.1016/j.cell.2015.01.008</a>.
  ieee: V. Ruprecht <i>et al.</i>, “Cortical contractility triggers a stochastic switch
    to fast amoeboid cell motility,” <i>Cell</i>, vol. 160, no. 4. Cell Press, pp.
    673–685, 2015.
  ista: Ruprecht V, Wieser S, Callan Jones A, Smutny M, Morita H, Sako K, Barone V,
    Ritsch Marte M, Sixt MK, Voituriez R, Heisenberg C-PJ. 2015. Cortical contractility
    triggers a stochastic switch to fast amoeboid cell motility. Cell. 160(4), 673–685.
  mla: Ruprecht, Verena, et al. “Cortical Contractility Triggers a Stochastic Switch
    to Fast Amoeboid Cell Motility.” <i>Cell</i>, vol. 160, no. 4, Cell Press, 2015,
    pp. 673–85, doi:<a href="https://doi.org/10.1016/j.cell.2015.01.008">10.1016/j.cell.2015.01.008</a>.
  short: V. Ruprecht, S. Wieser, A. Callan Jones, M. Smutny, H. Morita, K. Sako, V.
    Barone, M. Ritsch Marte, M.K. Sixt, R. Voituriez, C.-P.J. Heisenberg, Cell 160
    (2015) 673–685.
date_created: 2018-12-11T11:52:35Z
date_published: 2015-02-12T00:00:00Z
date_updated: 2023-09-07T12:05:08Z
day: '12'
ddc:
- '570'
department:
- _id: CaHe
- _id: MiSi
doi: 10.1016/j.cell.2015.01.008
file:
- access_level: open_access
  checksum: 228d3edf40627d897b3875088a0ac51f
  content_type: application/pdf
  creator: system
  date_created: 2018-12-12T10:13:21Z
  date_updated: 2020-07-14T12:45:01Z
  file_id: '5003'
  file_name: IST-2016-484-v1+1_1-s2.0-S0092867415000094-main.pdf
  file_size: 4362653
  relation: main_file
file_date_updated: 2020-07-14T12:45:01Z
has_accepted_license: '1'
intvolume: '       160'
issue: '4'
language:
- iso: eng
month: '02'
oa: 1
oa_version: Published Version
page: 673 - 685
project:
- _id: 2529486C-B435-11E9-9278-68D0E5697425
  call_identifier: FWF
  grant_number: T 560-B17
  name: Cell- and Tissue Mechanics in Zebrafish Germ Layer Formation
- _id: 2527D5CC-B435-11E9-9278-68D0E5697425
  call_identifier: FWF
  grant_number: I 812-B12
  name: Cell Cortex and Germ Layer Formation in Zebrafish Gastrulation
publication: Cell
publication_status: published
publisher: Cell Press
publist_id: '5634'
pubrep_id: '484'
quality_controlled: '1'
related_material:
  record:
  - id: '961'
    relation: dissertation_contains
    status: public
scopus_import: 1
status: public
title: Cortical contractility triggers a stochastic switch to fast amoeboid cell motility
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 4435EBFC-F248-11E8-B48F-1D18A9856A87
volume: 160
year: '2015'
...
---
_id: '10815'
abstract:
- lang: eng
  text: In the last several decades, developmental biology has clarified the molecular
    mechanisms of embryogenesis and organogenesis. In particular, it has demonstrated
    that the “tool-kit genes” essential for regulating developmental processes are
    not only highly conserved among species, but are also used as systems at various
    times and places in an organism to control distinct developmental events. Therefore,
    mutations in many of these tool-kit genes may cause congenital diseases involving
    morphological abnormalities. This link between genes and abnormal morphological
    phenotypes underscores the importance of understanding how cells behave and contribute
    to morphogenesis as a result of gene function. Recent improvements in live imaging
    and in quantitative analyses of cellular dynamics will advance our understanding
    of the cellular pathogenesis of congenital diseases associated with aberrant morphologies.
    In these studies, it is critical to select an appropriate model organism for the
    particular phenomenon of interest.
acknowledgement: The authors thank all the members of the Division of Morphogenesis,
  National Institute for Basic Biology, for their contributions to the research, their
  encouragement, and helpful discussions, particularly Dr M. Suzuki for his critical
  reading of the manuscript. We also thank the Model Animal Research and Spectrography
  and Bioimaging Facilities, NIBB Core Research Facilities, for technical support.
  M.H. was supported by a research fellowship from the Japan Society for the Promotion
  of Science (JSPS). Our work introduced in this review was supported by a Grant-in-Aid
  for Scientific Research on Innovative Areas from the Ministry of Education, Culture,
  Sports, Science, and Technology (MEXT), Japan, to N.U.
article_processing_charge: No
article_type: original
author:
- first_name: Masakazu
  full_name: Hashimoto, Masakazu
  last_name: Hashimoto
- first_name: Hitoshi
  full_name: Morita, Hitoshi
  id: 4C6E54C6-F248-11E8-B48F-1D18A9856A87
  last_name: Morita
- first_name: Naoto
  full_name: Ueno, Naoto
  last_name: Ueno
citation:
  ama: Hashimoto M, Morita H, Ueno N. Molecular and cellular mechanisms of development
    underlying congenital diseases. <i>Congenital Anomalies</i>. 2014;54(1):1-7. doi:<a
    href="https://doi.org/10.1111/cga.12039">10.1111/cga.12039</a>
  apa: Hashimoto, M., Morita, H., &#38; Ueno, N. (2014). Molecular and cellular mechanisms
    of development underlying congenital diseases. <i>Congenital Anomalies</i>. Wiley.
    <a href="https://doi.org/10.1111/cga.12039">https://doi.org/10.1111/cga.12039</a>
  chicago: Hashimoto, Masakazu, Hitoshi Morita, and Naoto Ueno. “Molecular and Cellular
    Mechanisms of Development Underlying Congenital Diseases.” <i>Congenital Anomalies</i>.
    Wiley, 2014. <a href="https://doi.org/10.1111/cga.12039">https://doi.org/10.1111/cga.12039</a>.
  ieee: M. Hashimoto, H. Morita, and N. Ueno, “Molecular and cellular mechanisms of
    development underlying congenital diseases,” <i>Congenital Anomalies</i>, vol.
    54, no. 1. Wiley, pp. 1–7, 2014.
  ista: Hashimoto M, Morita H, Ueno N. 2014. Molecular and cellular mechanisms of
    development underlying congenital diseases. Congenital Anomalies. 54(1), 1–7.
  mla: Hashimoto, Masakazu, et al. “Molecular and Cellular Mechanisms of Development
    Underlying Congenital Diseases.” <i>Congenital Anomalies</i>, vol. 54, no. 1,
    Wiley, 2014, pp. 1–7, doi:<a href="https://doi.org/10.1111/cga.12039">10.1111/cga.12039</a>.
  short: M. Hashimoto, H. Morita, N. Ueno, Congenital Anomalies 54 (2014) 1–7.
date_created: 2022-03-04T08:17:25Z
date_published: 2014-02-01T00:00:00Z
date_updated: 2022-03-04T08:26:05Z
day: '01'
department:
- _id: CaHe
doi: 10.1111/cga.12039
external_id:
  pmid:
  - '24666178'
intvolume: '        54'
issue: '1'
keyword:
- Developmental Biology
- Embryology
- General Medicine
- Pediatrics
- Perinatology
- and Child Health
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://doi.org/10.1111/cga.12039
month: '02'
oa: 1
oa_version: None
page: 1-7
pmid: 1
publication: Congenital Anomalies
publication_identifier:
  issn:
  - 0914-3505
publication_status: published
publisher: Wiley
quality_controlled: '1'
scopus_import: '1'
status: public
title: Molecular and cellular mechanisms of development underlying congenital diseases
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 54
year: '2014'
...
---
_id: '2841'
abstract:
- lang: eng
  text: In zebrafish early development, blastoderm cells undergo extensive radial
    intercalations, triggering the spreading of the blastoderm over the yolk cell
    and thereby initiating embryonic body axis formation. Now reporting in Developmental
    Cell, Song et al. (2013) demonstrate a critical function for EGF-dependent E-cadherin
    endocytosis in promoting blastoderm cell intercalations.
author:
- first_name: Hitoshi
  full_name: Morita, Hitoshi
  id: 4C6E54C6-F248-11E8-B48F-1D18A9856A87
  last_name: Morita
- first_name: Carl-Philipp J
  full_name: Heisenberg, Carl-Philipp J
  id: 39427864-F248-11E8-B48F-1D18A9856A87
  last_name: Heisenberg
  orcid: 0000-0002-0912-4566
citation:
  ama: 'Morita H, Heisenberg C-PJ. Holding on and letting go: Cadherin turnover in
    cell intercalation. <i>Developmental Cell</i>. 2013;24(6):567-569. doi:<a href="https://doi.org/10.1016/j.devcel.2013.03.007">10.1016/j.devcel.2013.03.007</a>'
  apa: 'Morita, H., &#38; Heisenberg, C.-P. J. (2013). Holding on and letting go:
    Cadherin turnover in cell intercalation. <i>Developmental Cell</i>. Cell Press.
    <a href="https://doi.org/10.1016/j.devcel.2013.03.007">https://doi.org/10.1016/j.devcel.2013.03.007</a>'
  chicago: 'Morita, Hitoshi, and Carl-Philipp J Heisenberg. “Holding on and Letting
    Go: Cadherin Turnover in Cell Intercalation.” <i>Developmental Cell</i>. Cell
    Press, 2013. <a href="https://doi.org/10.1016/j.devcel.2013.03.007">https://doi.org/10.1016/j.devcel.2013.03.007</a>.'
  ieee: 'H. Morita and C.-P. J. Heisenberg, “Holding on and letting go: Cadherin turnover
    in cell intercalation,” <i>Developmental Cell</i>, vol. 24, no. 6. Cell Press,
    pp. 567–569, 2013.'
  ista: 'Morita H, Heisenberg C-PJ. 2013. Holding on and letting go: Cadherin turnover
    in cell intercalation. Developmental Cell. 24(6), 567–569.'
  mla: 'Morita, Hitoshi, and Carl-Philipp J. Heisenberg. “Holding on and Letting Go:
    Cadherin Turnover in Cell Intercalation.” <i>Developmental Cell</i>, vol. 24,
    no. 6, Cell Press, 2013, pp. 567–69, doi:<a href="https://doi.org/10.1016/j.devcel.2013.03.007">10.1016/j.devcel.2013.03.007</a>.'
  short: H. Morita, C.-P.J. Heisenberg, Developmental Cell 24 (2013) 567–569.
date_created: 2018-12-11T11:59:52Z
date_published: 2013-05-25T00:00:00Z
date_updated: 2021-01-12T07:00:09Z
day: '25'
department:
- _id: CaHe
doi: 10.1016/j.devcel.2013.03.007
intvolume: '        24'
issue: '6'
language:
- iso: eng
month: '05'
oa_version: None
page: 567 - 569
publication: Developmental Cell
publication_status: published
publisher: Cell Press
publist_id: '3956'
quality_controlled: '1'
scopus_import: 1
status: public
title: 'Holding on and letting go: Cadherin turnover in cell intercalation'
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 24
year: '2013'
...