[{"keyword":["Genetics"],"isi":1,"year":"2022","related_material":{"record":[{"id":"11653","status":"public","relation":"research_data"}]},"external_id":{"isi":["000850270300001"],"pmid":["35977389"]},"ec_funded":1,"pmid":1,"date_published":"2022-10-01T00:00:00Z","acknowledgement":"This work was supported by the European Research Council under the European Union’s Horizon 2020 research and innovation program (grant agreement no. 715257) and by the Austrian Science Foundation (FWF SFB F88-10).\r\nWe thank the Vicoso group for comments on the manuscript and the ISTA Scientific computing team and the Vienna Biocenter Sequencing facility for technical support.","publication":"Genetics","status":"public","project":[{"_id":"250BDE62-B435-11E9-9278-68D0E5697425","name":"Prevalence and Influence of Sexual Antagonism on Genome Evolution","grant_number":"715257","call_identifier":"H2020"},{"_id":"34ae1506-11ca-11ed-8bc3-c14f4c474396","grant_number":"F8810","name":"The highjacking of meiosis for asexual reproduction"}],"_id":"12248","date_updated":"2024-03-25T23:30:26Z","type":"journal_article","article_processing_charge":"No","doi":"10.1093/genetics/iyac123","publisher":"Oxford University Press","quality_controlled":"1","ddc":["570"],"department":[{"_id":"BeVi"}],"article_number":"iyac123","file":[{"file_id":"12440","creator":"dernst","date_updated":"2023-01-30T08:59:58Z","date_created":"2023-01-30T08:59:58Z","file_size":1347136,"checksum":"f79ff5383e882ea3f95f3da47a78029d","relation":"main_file","access_level":"open_access","content_type":"application/pdf","success":1,"file_name":"2022_Genetics_Elkrewi.pdf"}],"month":"10","citation":{"mla":"Elkrewi, Marwan N., et al. “ZW Sex-Chromosome Evolution and Contagious Parthenogenesis in Artemia Brine Shrimp.” <i>Genetics</i>, vol. 222, no. 2, iyac123, Oxford University Press, 2022, doi:<a href=\"https://doi.org/10.1093/genetics/iyac123\">10.1093/genetics/iyac123</a>.","apa":"Elkrewi, M. N., Khauratovich, U., Toups, M. A., Bett, V. K., Mrnjavac, A., Macon, A., … Vicoso, B. (2022). ZW sex-chromosome evolution and contagious parthenogenesis in Artemia brine shrimp. <i>Genetics</i>. Oxford University Press. <a href=\"https://doi.org/10.1093/genetics/iyac123\">https://doi.org/10.1093/genetics/iyac123</a>","chicago":"Elkrewi, Marwan N, Uladzislava Khauratovich, Melissa A Toups, Vincent K Bett, Andrea Mrnjavac, Ariana Macon, Christelle Fraisse, et al. “ZW Sex-Chromosome Evolution and Contagious Parthenogenesis in Artemia Brine Shrimp.” <i>Genetics</i>. Oxford University Press, 2022. <a href=\"https://doi.org/10.1093/genetics/iyac123\">https://doi.org/10.1093/genetics/iyac123</a>.","ista":"Elkrewi MN, Khauratovich U, Toups MA, Bett VK, Mrnjavac A, Macon A, Fraisse C, Sax L, Huylmans AK, Hontoria F, Vicoso B. 2022. ZW sex-chromosome evolution and contagious parthenogenesis in Artemia brine shrimp. Genetics. 222(2), iyac123.","short":"M.N. Elkrewi, U. Khauratovich, M.A. Toups, V.K. Bett, A. Mrnjavac, A. Macon, C. Fraisse, L. Sax, A.K. Huylmans, F. Hontoria, B. Vicoso, Genetics 222 (2022).","ieee":"M. N. Elkrewi <i>et al.</i>, “ZW sex-chromosome evolution and contagious parthenogenesis in Artemia brine shrimp,” <i>Genetics</i>, vol. 222, no. 2. Oxford University Press, 2022.","ama":"Elkrewi MN, Khauratovich U, Toups MA, et al. ZW sex-chromosome evolution and contagious parthenogenesis in Artemia brine shrimp. <i>Genetics</i>. 2022;222(2). doi:<a href=\"https://doi.org/10.1093/genetics/iyac123\">10.1093/genetics/iyac123</a>"},"issue":"2","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","oa":1,"language":[{"iso":"eng"}],"volume":222,"date_created":"2023-01-16T09:56:10Z","article_type":"original","day":"01","scopus_import":"1","author":[{"full_name":"Elkrewi, Marwan N","id":"0B46FACA-A8E1-11E9-9BD3-79D1E5697425","last_name":"Elkrewi","first_name":"Marwan N","orcid":"0000-0002-5328-7231"},{"first_name":"Uladzislava","id":"5eba06f4-97d8-11ed-9f8f-d826ebdd9434","full_name":"Khauratovich, Uladzislava","last_name":"Khauratovich"},{"id":"4E099E4E-F248-11E8-B48F-1D18A9856A87","full_name":"Toups, Melissa A","last_name":"Toups","orcid":"0000-0002-9752-7380","first_name":"Melissa A"},{"first_name":"Vincent K","last_name":"Bett","full_name":"Bett, Vincent K","id":"57854184-AAE0-11E9-8D04-98D6E5697425"},{"id":"353FAC84-AE61-11E9-8BFC-00D3E5697425","full_name":"Mrnjavac, Andrea","last_name":"Mrnjavac","first_name":"Andrea"},{"first_name":"Ariana","full_name":"Macon, Ariana","id":"2A0848E2-F248-11E8-B48F-1D18A9856A87","last_name":"Macon"},{"full_name":"Fraisse, Christelle","id":"32DF5794-F248-11E8-B48F-1D18A9856A87","last_name":"Fraisse","first_name":"Christelle","orcid":"0000-0001-8441-5075"},{"id":"701c5602-97d8-11ed-96b5-b52773c70189","full_name":"Sax, Luca","last_name":"Sax","first_name":"Luca"},{"id":"4C0A3874-F248-11E8-B48F-1D18A9856A87","full_name":"Huylmans, Ann K","last_name":"Huylmans","orcid":"0000-0001-8871-4961","first_name":"Ann K"},{"first_name":"Francisco","full_name":"Hontoria, Francisco","last_name":"Hontoria"},{"last_name":"Vicoso","id":"49E1C5C6-F248-11E8-B48F-1D18A9856A87","full_name":"Vicoso, Beatriz","first_name":"Beatriz","orcid":"0000-0002-4579-8306"}],"oa_version":"Published Version","title":"ZW sex-chromosome evolution and contagious parthenogenesis in Artemia brine shrimp","file_date_updated":"2023-01-30T08:59:58Z","publication_status":"published","publication_identifier":{"issn":["1943-2631"]},"has_accepted_license":"1","acknowledged_ssus":[{"_id":"ScienComp"}],"abstract":[{"lang":"eng","text":"Eurasian brine shrimp (genus Artemia) have closely related sexual and asexual lineages of parthenogenetic females, which produce rare males at low frequencies. Although they are known to have ZW chromosomes, these are not well characterized, and it is unclear whether they are shared across the clade. Furthermore, the underlying genetic architecture of the transmission of asexuality, which can occur when rare males mate with closely related sexual females, is not well understood. We produced a chromosome-level assembly for the sexual Eurasian species Artemia sinica and characterized in detail the pair of sex chromosomes of this species. We combined this new assembly with short-read genomic data for the sexual species Artemia sp. Kazakhstan and several asexual lineages of Artemia parthenogenetica, allowing us to perform an in-depth characterization of sex-chromosome evolution across the genus. We identified a small differentiated region of the ZW pair that is shared by all sexual and asexual lineages, supporting the shared ancestry of the sex chromosomes. We also inferred that recombination suppression has spread to larger sections of the chromosome independently in the American and Eurasian lineages. Finally, we took advantage of a rare male, which we backcrossed to sexual females, to explore the genetic basis of asexuality. Our results suggest that parthenogenesis is likely partly controlled by a locus on the Z chromosome, highlighting the interplay between sex determination and asexuality."}],"tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","short":"CC BY (4.0)"},"intvolume":"       222"},{"department":[{"_id":"BeVi"}],"file":[{"content_type":"application/pdf","access_level":"open_access","file_name":"2021_ProRoSocBBioSci_Huylmans.pdf","success":1,"checksum":"76e7f253b7040bca2ad76f82bd7c45c0","relation":"main_file","creator":"cchlebak","date_updated":"2021-10-22T11:48:02Z","date_created":"2021-10-22T11:48:02Z","file_size":995806,"file_id":"10172"}],"article_number":"20211720","month":"09","issue":"1959","citation":{"ista":"Huylmans AK, Macon A, Hontoria F, Vicoso B. 2021. Transitions to asexuality and evolution of gene expression in Artemia brine shrimp. Proceedings of the Royal Society B: Biological Sciences. 288(1959), 20211720.","chicago":"Huylmans, Ann K, Ariana Macon, Francisco Hontoria, and Beatriz Vicoso. “Transitions to Asexuality and Evolution of Gene Expression in Artemia Brine Shrimp.” <i>Proceedings of the Royal Society B: Biological Sciences</i>. The Royal Society, 2021. <a href=\"https://doi.org/10.1098/rspb.2021.1720\">https://doi.org/10.1098/rspb.2021.1720</a>.","mla":"Huylmans, Ann K., et al. “Transitions to Asexuality and Evolution of Gene Expression in Artemia Brine Shrimp.” <i>Proceedings of the Royal Society B: Biological Sciences</i>, vol. 288, no. 1959, 20211720, The Royal Society, 2021, doi:<a href=\"https://doi.org/10.1098/rspb.2021.1720\">10.1098/rspb.2021.1720</a>.","apa":"Huylmans, A. K., Macon, A., Hontoria, F., &#38; Vicoso, B. (2021). Transitions to asexuality and evolution of gene expression in Artemia brine shrimp. <i>Proceedings of the Royal Society B: Biological Sciences</i>. The Royal Society. <a href=\"https://doi.org/10.1098/rspb.2021.1720\">https://doi.org/10.1098/rspb.2021.1720</a>","ama":"Huylmans AK, Macon A, Hontoria F, Vicoso B. Transitions to asexuality and evolution of gene expression in Artemia brine shrimp. <i>Proceedings of the Royal Society B: Biological Sciences</i>. 2021;288(1959). doi:<a href=\"https://doi.org/10.1098/rspb.2021.1720\">10.1098/rspb.2021.1720</a>","short":"A.K. Huylmans, A. Macon, F. Hontoria, B. Vicoso, Proceedings of the Royal Society B: Biological Sciences 288 (2021).","ieee":"A. K. Huylmans, A. Macon, F. Hontoria, and B. Vicoso, “Transitions to asexuality and evolution of gene expression in Artemia brine shrimp,” <i>Proceedings of the Royal Society B: Biological Sciences</i>, vol. 288, no. 1959. The Royal Society, 2021."},"user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","oa":1,"language":[{"iso":"eng"}],"volume":288,"article_type":"original","date_created":"2021-10-21T07:46:06Z","author":[{"id":"4C0A3874-F248-11E8-B48F-1D18A9856A87","full_name":"Huylmans, Ann K","last_name":"Huylmans","first_name":"Ann K","orcid":"0000-0001-8871-4961"},{"first_name":"Ariana","full_name":"Macon, Ariana","id":"2A0848E2-F248-11E8-B48F-1D18A9856A87","last_name":"Macon"},{"first_name":"Francisco","last_name":"Hontoria","full_name":"Hontoria, Francisco"},{"first_name":"Beatriz","orcid":"0000-0002-4579-8306","id":"49E1C5C6-F248-11E8-B48F-1D18A9856A87","full_name":"Vicoso, Beatriz","last_name":"Vicoso"}],"scopus_import":"1","day":"22","title":"Transitions to asexuality and evolution of gene expression in Artemia brine shrimp","oa_version":"Published Version","publication_identifier":{"issn":["0962-8452"],"eissn":["1471-2954"]},"publication_status":"published","file_date_updated":"2021-10-22T11:48:02Z","has_accepted_license":"1","tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","short":"CC BY (4.0)"},"intvolume":"       288","abstract":[{"lang":"eng","text":"While sexual reproduction is widespread among many taxa, asexual lineages have repeatedly evolved from sexual ancestors. Despite extensive research on the evolution of sex, it is still unclear whether this switch represents a major transition requiring major molecular reorganization, and how convergent the changes involved are. In this study, we investigated the phylogenetic relationship and patterns of gene expression of sexual and asexual lineages of Eurasian Artemia brine shrimp, to assess how gene expression patterns are affected by the transition to asexuality. We find only a few genes that are consistently associated with the evolution of asexuality, suggesting that this shift may not require an extensive overhauling of the meiotic machinery. While genes with sex-biased expression have high rates of expression divergence within Eurasian Artemia, neither female- nor male-biased genes appear to show unusual evolutionary patterns after sexuality is lost, contrary to theoretical expectations."}],"acknowledged_ssus":[{"_id":"ScienComp"}],"keyword":["asexual reproduction","parthenogenesis","sex-biased genes","sexual conflict","automixis","crustaceans"],"year":"2021","isi":1,"external_id":{"pmid":["34547909"],"isi":["000697643700001"]},"related_material":{"link":[{"url":"https://doi.org/10.6084/m9.figshare.c.5615488.v1","relation":"supplementary_material"}],"record":[{"relation":"research_data","status":"public","id":"9949"}]},"pmid":1,"ec_funded":1,"acknowledgement":"We thank the Vicoso laboratory, Thomas Lenormand and Tanja Schwander for helpful discussions, the group of Gonzalo Gajardo, especially Cristian Gallardo-Escárate and Margarita Parraguez Donoso, for sequencing data and advice, and the IST Scientific Computing Group for their support. This work was supported by the European Research Council under the European Union's Horizon 2020 research and innovation program (grant agreement no. 715257).","date_published":"2021-09-22T00:00:00Z","project":[{"call_identifier":"H2020","grant_number":"715257","name":"Prevalence and Influence of Sexual Antagonism on Genome Evolution","_id":"250BDE62-B435-11E9-9278-68D0E5697425"}],"status":"public","publication":"Proceedings of the Royal Society B: Biological Sciences","date_updated":"2024-02-21T12:40:29Z","_id":"10166","type":"journal_article","doi":"10.1098/rspb.2021.1720","article_processing_charge":"Yes (via OA deal)","publisher":"The Royal Society","quality_controlled":"1","ddc":["595"]},{"date_updated":"2024-02-21T12:45:41Z","_id":"6418","type":"journal_article","doi":"10.1093/gbe/evz053","article_processing_charge":"No","publisher":"Oxford University Press","quality_controlled":"1","page":"1033-1044","ddc":["570"],"isi":1,"year":"2019","external_id":{"isi":["000476569800003"]},"related_material":{"record":[{"id":"6060","status":"public","relation":"popular_science"}]},"ec_funded":1,"date_published":"2019-04-01T00:00:00Z","project":[{"name":"Prevalence and Influence of Sexual Antagonism on Genome Evolution","grant_number":"715257","call_identifier":"H2020","_id":"250BDE62-B435-11E9-9278-68D0E5697425"}],"status":"public","publication":"Genome biology and evolution","volume":11,"date_created":"2019-05-13T07:58:38Z","author":[{"orcid":"0000-0001-8871-4961","first_name":"Ann K","id":"4C0A3874-F248-11E8-B48F-1D18A9856A87","full_name":"Huylmans, Ann K","last_name":"Huylmans"},{"first_name":"Melissa A","orcid":"0000-0002-9752-7380","full_name":"Toups, Melissa A","id":"4E099E4E-F248-11E8-B48F-1D18A9856A87","last_name":"Toups"},{"last_name":"Macon","id":"2A0848E2-F248-11E8-B48F-1D18A9856A87","full_name":"Macon, Ariana","first_name":"Ariana"},{"id":"3A7E01BC-F248-11E8-B48F-1D18A9856A87","full_name":"Gammerdinger, William J","last_name":"Gammerdinger","first_name":"William J","orcid":"0000-0001-9638-1220"},{"full_name":"Vicoso, Beatriz","id":"49E1C5C6-F248-11E8-B48F-1D18A9856A87","last_name":"Vicoso","first_name":"Beatriz","orcid":"0000-0002-4579-8306"}],"day":"01","scopus_import":"1","oa_version":"Published Version","title":"Sex-biased gene expression and dosage compensation on the Artemia franciscana Z-chromosome","publication_identifier":{"eissn":["1759-6653"]},"publication_status":"published","file_date_updated":"2020-07-14T12:47:29Z","has_accepted_license":"1","abstract":[{"text":"Males and females of Artemia franciscana, a crustacean commonly used in the aquarium trade, are highly dimorphic. Sex is determined by a pair of ZW chromosomes, but the nature and extent of differentiation of these chromosomes is unknown. Here, we characterize the Z chromosome by detecting genomic regions that show lower genomic coverage in female than in male samples, and regions that harbor an excess of female-specific SNPs. We detect many Z-specific genes, which no longer have homologs on the W, but also Z-linked genes that appear to have diverged very recently from their existing W-linked homolog. We assess patterns of male and female expression in two tissues with extensive morphological dimorphism, gonads, and heads. In agreement with their morphology, sex-biased expression is common in both tissues. Interestingly, the Z chromosome is not enriched for sex-biased genes, and seems to in fact have a mechanism of dosage compensation that leads to equal expression in males and in females. Both of these patterns are contrary to most ZW systems studied so far, making A. franciscana an excellent model for investigating the interplay between the evolution of sexual dimorphism and dosage compensation, as well as Z chromosome evolution in general.","lang":"eng"}],"tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","short":"CC BY (4.0)"},"intvolume":"        11","acknowledged_ssus":[{"_id":"ScienComp"}],"department":[{"_id":"BeVi"}],"file":[{"date_updated":"2020-07-14T12:47:29Z","creator":"dernst","file_size":1256303,"date_created":"2019-05-14T08:29:38Z","file_id":"6446","access_level":"open_access","content_type":"application/pdf","file_name":"2019_GBE_Huylmans.pdf","checksum":"7d0ede297b6741f3dc89cd59017c7642","relation":"main_file"}],"month":"04","issue":"4","citation":{"ieee":"A. K. Huylmans, M. A. Toups, A. Macon, W. J. Gammerdinger, and B. Vicoso, “Sex-biased gene expression and dosage compensation on the Artemia franciscana Z-chromosome,” <i>Genome biology and evolution</i>, vol. 11, no. 4. Oxford University Press, pp. 1033–1044, 2019.","short":"A.K. Huylmans, M.A. Toups, A. Macon, W.J. Gammerdinger, B. Vicoso, Genome Biology and Evolution 11 (2019) 1033–1044.","ama":"Huylmans AK, Toups MA, Macon A, Gammerdinger WJ, Vicoso B. Sex-biased gene expression and dosage compensation on the Artemia franciscana Z-chromosome. <i>Genome biology and evolution</i>. 2019;11(4):1033-1044. doi:<a href=\"https://doi.org/10.1093/gbe/evz053\">10.1093/gbe/evz053</a>","apa":"Huylmans, A. K., Toups, M. A., Macon, A., Gammerdinger, W. J., &#38; Vicoso, B. (2019). Sex-biased gene expression and dosage compensation on the Artemia franciscana Z-chromosome. <i>Genome Biology and Evolution</i>. Oxford University Press. <a href=\"https://doi.org/10.1093/gbe/evz053\">https://doi.org/10.1093/gbe/evz053</a>","mla":"Huylmans, Ann K., et al. “Sex-Biased Gene Expression and Dosage Compensation on the Artemia Franciscana Z-Chromosome.” <i>Genome Biology and Evolution</i>, vol. 11, no. 4, Oxford University Press, 2019, pp. 1033–44, doi:<a href=\"https://doi.org/10.1093/gbe/evz053\">10.1093/gbe/evz053</a>.","ista":"Huylmans AK, Toups MA, Macon A, Gammerdinger WJ, Vicoso B. 2019. Sex-biased gene expression and dosage compensation on the Artemia franciscana Z-chromosome. Genome biology and evolution. 11(4), 1033–1044.","chicago":"Huylmans, Ann K, Melissa A Toups, Ariana Macon, William J Gammerdinger, and Beatriz Vicoso. “Sex-Biased Gene Expression and Dosage Compensation on the Artemia Franciscana Z-Chromosome.” <i>Genome Biology and Evolution</i>. Oxford University Press, 2019. <a href=\"https://doi.org/10.1093/gbe/evz053\">https://doi.org/10.1093/gbe/evz053</a>."},"user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","oa":1,"language":[{"iso":"eng"}]},{"month":"07","department":[{"_id":"BeVi"}],"oa":1,"language":[{"iso":"eng"}],"citation":{"ama":"Harrison M, Arning N, Kremer L, et al. Expansions of key protein families in the German cockroach highlight the molecular basis of its remarkable success as a global indoor pest. <i>Journal of Experimental Zoology Part B: Molecular and Developmental Evolution</i>. 2018;330:254-264. doi:<a href=\"https://doi.org/10.1002/jez.b.22824\">10.1002/jez.b.22824</a>","ieee":"M. Harrison <i>et al.</i>, “Expansions of key protein families in the German cockroach highlight the molecular basis of its remarkable success as a global indoor pest,” <i>Journal of Experimental Zoology Part B: Molecular and Developmental Evolution</i>, vol. 330. Wiley, pp. 254–264, 2018.","short":"M. Harrison, N. Arning, L. Kremer, G. Ylla, X. Belles, E. Bornberg Bauer, A.K. Huylmans, E. Jongepier, M. Puilachs, S. Richards, C. Schal, Journal of Experimental Zoology Part B: Molecular and Developmental Evolution 330 (2018) 254–264.","ista":"Harrison M, Arning N, Kremer L, Ylla G, Belles X, Bornberg Bauer E, Huylmans AK, Jongepier E, Puilachs M, Richards S, Schal C. 2018. Expansions of key protein families in the German cockroach highlight the molecular basis of its remarkable success as a global indoor pest. Journal of Experimental Zoology Part B: Molecular and Developmental Evolution. 330, 254–264.","chicago":"Harrison, Mark, Nicolas Arning, Lucas Kremer, Guillem Ylla, Xavier Belles, Erich Bornberg Bauer, Ann K Huylmans, et al. “Expansions of Key Protein Families in the German Cockroach Highlight the Molecular Basis of Its Remarkable Success as a Global Indoor Pest.” <i>Journal of Experimental Zoology Part B: Molecular and Developmental Evolution</i>. Wiley, 2018. <a href=\"https://doi.org/10.1002/jez.b.22824\">https://doi.org/10.1002/jez.b.22824</a>.","apa":"Harrison, M., Arning, N., Kremer, L., Ylla, G., Belles, X., Bornberg Bauer, E., … Schal, C. (2018). Expansions of key protein families in the German cockroach highlight the molecular basis of its remarkable success as a global indoor pest. <i>Journal of Experimental Zoology Part B: Molecular and Developmental Evolution</i>. Wiley. <a href=\"https://doi.org/10.1002/jez.b.22824\">https://doi.org/10.1002/jez.b.22824</a>","mla":"Harrison, Mark, et al. “Expansions of Key Protein Families in the German Cockroach Highlight the Molecular Basis of Its Remarkable Success as a Global Indoor Pest.” <i>Journal of Experimental Zoology Part B: Molecular and Developmental Evolution</i>, vol. 330, Wiley, 2018, pp. 254–64, doi:<a href=\"https://doi.org/10.1002/jez.b.22824\">10.1002/jez.b.22824</a>."},"user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1","author":[{"full_name":"Harrison, Mark","last_name":"Harrison","first_name":"Mark"},{"first_name":"Nicolas","full_name":"Arning, Nicolas","last_name":"Arning"},{"last_name":"Kremer","full_name":"Kremer, Lucas","first_name":"Lucas"},{"first_name":"Guillem","full_name":"Ylla, Guillem","last_name":"Ylla"},{"first_name":"Xavier","last_name":"Belles","full_name":"Belles, Xavier"},{"full_name":"Bornberg Bauer, Erich","last_name":"Bornberg Bauer","first_name":"Erich"},{"first_name":"Ann K","orcid":"0000-0001-8871-4961","last_name":"Huylmans","id":"4C0A3874-F248-11E8-B48F-1D18A9856A87","full_name":"Huylmans, Ann K"},{"last_name":"Jongepier","full_name":"Jongepier, Evelien","first_name":"Evelien"},{"last_name":"Puilachs","full_name":"Puilachs, Maria","first_name":"Maria"},{"last_name":"Richards","full_name":"Richards, Stephen","first_name":"Stephen"},{"first_name":"Coby","last_name":"Schal","full_name":"Schal, Coby"}],"scopus_import":"1","day":"11","oa_version":"Submitted Version","title":"Expansions of key protein families in the German cockroach highlight the molecular basis of its remarkable success as a global indoor pest","volume":330,"article_type":"original","date_created":"2018-12-11T11:45:06Z","abstract":[{"text":"The German cockroach, Blattella germanica, is a worldwide pest that infests buildings, including homes, restaurants, and hospitals, often living in unsanitary conditions. As a disease vector and producer of allergens, this species has major health and economic impacts on humans. Factors contributing to the success of the German cockroach include its resistance to a broad range of insecticides, immunity to many pathogens, and its ability, as an extreme generalist omnivore, to survive on most food sources. The recently published genome shows that B. germanica has an exceptionally high number of protein coding genes. In this study, we investigate the functions of the 93 significantly expanded gene families with the aim to better understand the success of B. germanica as a major pest despite such inhospitable conditions. We find major expansions in gene families with functions related to the detoxification of insecticides and allelochemicals, defense against pathogens, digestion, sensory perception, and gene regulation. These expansions might have allowed B. germanica to develop multiple resistance mechanisms to insecticides and pathogens, and enabled a broad, flexible diet, thus explaining its success in unsanitary conditions and under recurrent chemical control. The findings and resources presented here provide insights for better understanding molecular mechanisms that will facilitate more effective cockroach control.","lang":"eng"}],"intvolume":"       330","publication_status":"published","year":"2018","isi":1,"external_id":{"isi":["000443231000002"],"pmid":["29998472"]},"publist_id":"7730","publication":"Journal of Experimental Zoology Part B: Molecular and Developmental Evolution","status":"public","pmid":1,"date_published":"2018-07-11T00:00:00Z","doi":"10.1002/jez.b.22824","article_processing_charge":"No","publisher":"Wiley","date_updated":"2023-09-11T13:59:54Z","_id":"190","type":"journal_article","page":"254-264","main_file_link":[{"open_access":"1","url":"https://onlinelibrary.wiley.com/doi/am-pdf/10.1002/jez.b.22824"}],"quality_controlled":"1"},{"abstract":[{"text":"Around 150 million years ago, eusocial termites evolved from within the cockroaches, 50 million years before eusocial Hymenoptera, such as bees and ants, appeared. Here, we report the 2-Gb genome of the German cockroach, Blattella germanica, and the 1.3-Gb genome of the drywood termite Cryptotermes secundus. We show evolutionary signatures of termite eusociality by comparing the genomes and transcriptomes of three termites and the cockroach against the background of 16 other eusocial and non-eusocial insects. Dramatic adaptive changes in genes underlying the production and perception of pheromones confirm the importance of chemical communication in the termites. These are accompanied by major changes in gene regulation and the molecular evolution of caste determination. Many of these results parallel molecular mechanisms of eusocial evolution in Hymenoptera. However, the specific solutions are remarkably different, thus revealing a striking case of convergence in one of the major evolutionary transitions in biological complexity.","lang":"eng"}],"main_file_link":[{"url":"https://doi.org/10.5061/dryad.51d4r","open_access":"1"}],"doi":"10.5061/dryad.51d4r","author":[{"full_name":"Harrison, Mark C.","last_name":"Harrison","first_name":"Mark C."},{"last_name":"Jongepier","full_name":"Jongepier, Evelien","first_name":"Evelien"},{"last_name":"Robertson","full_name":"Robertson, Hugh M.","first_name":"Hugh M."},{"last_name":"Arning","full_name":"Arning, Nicolas","first_name":"Nicolas"},{"first_name":"Tristan","last_name":"Bitard-Feildel","full_name":"Bitard-Feildel, Tristan"},{"first_name":"Hsu","full_name":"Chao, Hsu","last_name":"Chao"},{"first_name":"Christopher P.","last_name":"Childers","full_name":"Childers, Christopher P."},{"last_name":"Dinh","full_name":"Dinh, Huyen","first_name":"Huyen"},{"full_name":"Doddapaneni, Harshavardhan","last_name":"Doddapaneni","first_name":"Harshavardhan"},{"first_name":"Shannon","full_name":"Dugan, Shannon","last_name":"Dugan"},{"last_name":"Gowin","full_name":"Gowin, Johannes","first_name":"Johannes"},{"full_name":"Greiner, Carolin","last_name":"Greiner","first_name":"Carolin"},{"full_name":"Han, Yi","last_name":"Han","first_name":"Yi"},{"first_name":"Haofu","full_name":"Hu, Haofu","last_name":"Hu"},{"full_name":"Hughes, Daniel S. T.","last_name":"Hughes","first_name":"Daniel S. T."},{"orcid":"0000-0001-8871-4961","first_name":"Ann K","id":"4C0A3874-F248-11E8-B48F-1D18A9856A87","full_name":"Huylmans, Ann K","last_name":"Huylmans"},{"last_name":"Kemena","full_name":"Kemena, Carsten","first_name":"Carsten"},{"first_name":"Lukas P. M.","full_name":"Kremer, Lukas P. M.","last_name":"Kremer"},{"last_name":"Lee","full_name":"Lee, Sandra L.","first_name":"Sandra L."},{"last_name":"Lopez-Ezquerra","full_name":"Lopez-Ezquerra, Alberto","first_name":"Alberto"},{"first_name":"Ludovic","last_name":"Mallet","full_name":"Mallet, Ludovic"},{"full_name":"Monroy-Kuhn, Jose M.","last_name":"Monroy-Kuhn","first_name":"Jose M."},{"first_name":"Annabell","last_name":"Moser","full_name":"Moser, Annabell"},{"first_name":"Shwetha C.","full_name":"Murali, Shwetha C.","last_name":"Murali"},{"full_name":"Muzny, Donna M.","last_name":"Muzny","first_name":"Donna M."},{"first_name":"Saria","last_name":"Otani","full_name":"Otani, Saria"},{"first_name":"Maria-Dolors","last_name":"Piulachs","full_name":"Piulachs, Maria-Dolors"},{"last_name":"Poelchau","full_name":"Poelchau, Monica","first_name":"Monica"},{"first_name":"Jiaxin","last_name":"Qu","full_name":"Qu, Jiaxin"},{"last_name":"Schaub","full_name":"Schaub, Florentine","first_name":"Florentine"},{"first_name":"Ayako","full_name":"Wada-Katsumata, Ayako","last_name":"Wada-Katsumata"},{"first_name":"Kim C.","full_name":"Worley, Kim C.","last_name":"Worley"},{"first_name":"Qiaolin","full_name":"Xie, Qiaolin","last_name":"Xie"},{"last_name":"Ylla","full_name":"Ylla, Guillem","first_name":"Guillem"},{"first_name":"Michael","last_name":"Poulsen","full_name":"Poulsen, Michael"},{"first_name":"Richard A.","full_name":"Gibbs, Richard A.","last_name":"Gibbs"},{"first_name":"Coby","full_name":"Schal, Coby","last_name":"Schal"},{"first_name":"Stephen","full_name":"Richards, Stephen","last_name":"Richards"},{"last_name":"Belles","full_name":"Belles, Xavier","first_name":"Xavier"},{"first_name":"Judith","last_name":"Korb","full_name":"Korb, Judith"},{"full_name":"Bornberg-Bauer, Erich","last_name":"Bornberg-Bauer","first_name":"Erich"}],"article_processing_charge":"No","day":"12","oa_version":"Published Version","publisher":"Dryad","title":"Data from: Hemimetabolous genomes reveal molecular basis of termite eusociality","date_updated":"2023-09-11T14:10:56Z","_id":"9841","type":"research_data_reference","date_created":"2021-08-09T13:13:48Z","oa":1,"status":"public","citation":{"chicago":"Harrison, Mark C., Evelien Jongepier, Hugh M. Robertson, Nicolas Arning, Tristan Bitard-Feildel, Hsu Chao, Christopher P. Childers, et al. “Data from: Hemimetabolous Genomes Reveal Molecular Basis of Termite Eusociality.” Dryad, 2018. <a href=\"https://doi.org/10.5061/dryad.51d4r\">https://doi.org/10.5061/dryad.51d4r</a>.","ista":"Harrison MC, Jongepier E, Robertson HM, Arning N, Bitard-Feildel T, Chao H, Childers CP, Dinh H, Doddapaneni H, Dugan S, Gowin J, Greiner C, Han Y, Hu H, Hughes DST, Huylmans AK, Kemena C, Kremer LPM, Lee SL, Lopez-Ezquerra A, Mallet L, Monroy-Kuhn JM, Moser A, Murali SC, Muzny DM, Otani S, Piulachs M-D, Poelchau M, Qu J, Schaub F, Wada-Katsumata A, Worley KC, Xie Q, Ylla G, Poulsen M, Gibbs RA, Schal C, Richards S, Belles X, Korb J, Bornberg-Bauer E. 2018. Data from: Hemimetabolous genomes reveal molecular basis of termite eusociality, Dryad, <a href=\"https://doi.org/10.5061/dryad.51d4r\">10.5061/dryad.51d4r</a>.","apa":"Harrison, M. C., Jongepier, E., Robertson, H. M., Arning, N., Bitard-Feildel, T., Chao, H., … Bornberg-Bauer, E. (2018). Data from: Hemimetabolous genomes reveal molecular basis of termite eusociality. Dryad. <a href=\"https://doi.org/10.5061/dryad.51d4r\">https://doi.org/10.5061/dryad.51d4r</a>","mla":"Harrison, Mark C., et al. <i>Data from: Hemimetabolous Genomes Reveal Molecular Basis of Termite Eusociality</i>. Dryad, 2018, doi:<a href=\"https://doi.org/10.5061/dryad.51d4r\">10.5061/dryad.51d4r</a>.","ama":"Harrison MC, Jongepier E, Robertson HM, et al. Data from: Hemimetabolous genomes reveal molecular basis of termite eusociality. 2018. doi:<a href=\"https://doi.org/10.5061/dryad.51d4r\">10.5061/dryad.51d4r</a>","ieee":"M. C. Harrison <i>et al.</i>, “Data from: Hemimetabolous genomes reveal molecular basis of termite eusociality.” Dryad, 2018.","short":"M.C. Harrison, E. Jongepier, H.M. Robertson, N. Arning, T. Bitard-Feildel, H. Chao, C.P. Childers, H. Dinh, H. Doddapaneni, S. Dugan, J. Gowin, C. Greiner, Y. Han, H. Hu, D.S.T. Hughes, A.K. Huylmans, C. Kemena, L.P.M. Kremer, S.L. Lee, A. Lopez-Ezquerra, L. Mallet, J.M. Monroy-Kuhn, A. Moser, S.C. Murali, D.M. Muzny, S. Otani, M.-D. Piulachs, M. Poelchau, J. Qu, F. Schaub, A. Wada-Katsumata, K.C. Worley, Q. Xie, G. Ylla, M. Poulsen, R.A. Gibbs, C. Schal, S. Richards, X. Belles, J. Korb, E. Bornberg-Bauer, (2018)."},"date_published":"2018-12-12T00:00:00Z","user_id":"6785fbc1-c503-11eb-8a32-93094b40e1cf","year":"2018","related_material":{"record":[{"relation":"used_in_publication","status":"public","id":"448"}]},"month":"12","department":[{"_id":"BeVi"}]},{"external_id":{"isi":["000426559600026"]},"related_material":{"record":[{"status":"public","relation":"research_data","id":"9841"}]},"isi":1,"year":"2018","publist_id":"7375","publication":"Nature Ecology and Evolution","status":"public","date_published":"2018-02-05T00:00:00Z","acknowledgement":"We thank O. Niehuis for allowing use of the unpublished E. danica genome, J. Gadau and C. Smith for comments and advice on the manuscript, and J. Schmitz for assistance with analyses and proofreading the manuscript. J.K. thanks Charles Darwin University (Australia), especially S. Garnett and the Horticulture and Aquaculture team, for providing logistic support to collect C. secundus. The Parks and Wildlife Commission, Northern Territory, the Department of the Environment, Water, Heritage and the Arts gave permission to collect (Permit number 36401) and export (Permit WT2010-6997) the termites. USDA is an equal opportunity provider and employer. M.C.H. and E.J. are supported by DFG grant BO2544/11-1 to E.B.-B. J.K. is supported by University of Osnabrück and DFG grant KO1895/16-1. X.B. and M.-D.P. are supported by Spanish Ministerio de Economía y Competitividad (CGL2012-36251 and CGL2015-64727-P to X.B., and CGL2016-76011-R to M.-D.P.), including FEDER funds, and by Catalan Government (2014 SGR 619). C.S. is supported by grants from the US Department of Housing and Urban Development (NCHHU-0017-13), the National Science Foundation (IOS-1557864), the Alfred P. Sloan Foundation (2013-5-35 MBE), the National Institute of Environmental Health Sciences (P30ES025128) to the Center for Human Health and the Environment, and the Blanton J. Whitmire Endowment. M.P. is supported by a Villum Kann Rasmussen Young Investigator Fellowship (VKR10101).","publisher":"Springer Nature","doi":"10.1038/s41559-017-0459-1","article_processing_charge":"No","type":"journal_article","date_updated":"2023-09-11T14:10:57Z","_id":"448","ddc":["576"],"page":"557-566","quality_controlled":"1","month":"02","file":[{"file_id":"4731","date_created":"2018-12-12T10:09:08Z","file_size":3730583,"date_updated":"2020-07-14T12:46:30Z","creator":"system","relation":"main_file","checksum":"874953136ac125e65f37971d3cabc5b7","file_name":"IST-2018-969-v1+1_2018_Huylmans_Hemimetabolous_genomes.pdf","content_type":"application/pdf","access_level":"open_access"}],"department":[{"_id":"BeVi"}],"language":[{"iso":"eng"}],"pubrep_id":"969","oa":1,"user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1","issue":"3","citation":{"ama":"Harrison M, Jongepier E, Robertson H, et al. Hemimetabolous genomes reveal molecular basis of termite eusociality. <i>Nature Ecology and Evolution</i>. 2018;2(3):557-566. doi:<a href=\"https://doi.org/10.1038/s41559-017-0459-1\">10.1038/s41559-017-0459-1</a>","ieee":"M. Harrison <i>et al.</i>, “Hemimetabolous genomes reveal molecular basis of termite eusociality,” <i>Nature Ecology and Evolution</i>, vol. 2, no. 3. Springer Nature, pp. 557–566, 2018.","short":"M. Harrison, E. Jongepier, H. Robertson, N. Arning, T. Bitard Feildel, H. Chao, C. Childers, H. Dinh, H. Doddapaneni, S. Dugan, J. Gowin, C. Greiner, Y. Han, H. Hu, D. Hughes, A.K. Huylmans, K. Kemena, L. Kremer, S. Lee, A. López Ezquerra, L. Mallet, J. Monroy Kuhn, A. Moser, S. Murali, D. Muzny, S. Otani, M. Piulachs, M. Poelchau, J. Qu, F. Schaub, A. Wada Katsumata, K. Worley, Q. Xie, G. Ylla, M. Poulsen, R. Gibbs, C. Schal, S. Richards, X. Belles, J. Korb, E. Bornberg Bauer, Nature Ecology and Evolution 2 (2018) 557–566.","ista":"Harrison M, Jongepier E, Robertson H, Arning N, Bitard Feildel T, Chao H, Childers C, Dinh H, Doddapaneni H, Dugan S, Gowin J, Greiner C, Han Y, Hu H, Hughes D, Huylmans AK, Kemena K, Kremer L, Lee S, López Ezquerra A, Mallet L, Monroy Kuhn J, Moser A, Murali S, Muzny D, Otani S, Piulachs M, Poelchau M, Qu J, Schaub F, Wada Katsumata A, Worley K, Xie Q, Ylla G, Poulsen M, Gibbs R, Schal C, Richards S, Belles X, Korb J, Bornberg Bauer E. 2018. Hemimetabolous genomes reveal molecular basis of termite eusociality. Nature Ecology and Evolution. 2(3), 557–566.","chicago":"Harrison, Mark, Evelien Jongepier, Hugh Robertson, Nicolas Arning, Tristan Bitard Feildel, Hsu Chao, Christopher Childers, et al. “Hemimetabolous Genomes Reveal Molecular Basis of Termite Eusociality.” <i>Nature Ecology and Evolution</i>. Springer Nature, 2018. <a href=\"https://doi.org/10.1038/s41559-017-0459-1\">https://doi.org/10.1038/s41559-017-0459-1</a>.","apa":"Harrison, M., Jongepier, E., Robertson, H., Arning, N., Bitard Feildel, T., Chao, H., … Bornberg Bauer, E. (2018). Hemimetabolous genomes reveal molecular basis of termite eusociality. <i>Nature Ecology and Evolution</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41559-017-0459-1\">https://doi.org/10.1038/s41559-017-0459-1</a>","mla":"Harrison, Mark, et al. “Hemimetabolous Genomes Reveal Molecular Basis of Termite Eusociality.” <i>Nature Ecology and Evolution</i>, vol. 2, no. 3, Springer Nature, 2018, pp. 557–66, doi:<a href=\"https://doi.org/10.1038/s41559-017-0459-1\">10.1038/s41559-017-0459-1</a>."},"title":"Hemimetabolous genomes reveal molecular basis of termite eusociality","oa_version":"Published Version","author":[{"first_name":"Mark","full_name":"Harrison, Mark","last_name":"Harrison"},{"first_name":"Evelien","last_name":"Jongepier","full_name":"Jongepier, Evelien"},{"full_name":"Robertson, Hugh","last_name":"Robertson","first_name":"Hugh"},{"last_name":"Arning","full_name":"Arning, Nicolas","first_name":"Nicolas"},{"first_name":"Tristan","last_name":"Bitard Feildel","full_name":"Bitard Feildel, Tristan"},{"first_name":"Hsu","last_name":"Chao","full_name":"Chao, Hsu"},{"last_name":"Childers","full_name":"Childers, Christopher","first_name":"Christopher"},{"first_name":"Huyen","full_name":"Dinh, Huyen","last_name":"Dinh"},{"first_name":"Harshavardhan","last_name":"Doddapaneni","full_name":"Doddapaneni, Harshavardhan"},{"full_name":"Dugan, Shannon","last_name":"Dugan","first_name":"Shannon"},{"last_name":"Gowin","full_name":"Gowin, Johannes","first_name":"Johannes"},{"first_name":"Carolin","full_name":"Greiner, Carolin","last_name":"Greiner"},{"first_name":"Yi","full_name":"Han, Yi","last_name":"Han"},{"full_name":"Hu, Haofu","last_name":"Hu","first_name":"Haofu"},{"first_name":"Daniel","full_name":"Hughes, Daniel","last_name":"Hughes"},{"last_name":"Huylmans","id":"4C0A3874-F248-11E8-B48F-1D18A9856A87","full_name":"Huylmans, Ann K","orcid":"0000-0001-8871-4961","first_name":"Ann K"},{"last_name":"Kemena","full_name":"Kemena, Karsten","first_name":"Karsten"},{"full_name":"Kremer, Lukas","last_name":"Kremer","first_name":"Lukas"},{"first_name":"Sandra","last_name":"Lee","full_name":"Lee, Sandra"},{"full_name":"López Ezquerra, Alberto","last_name":"López Ezquerra","first_name":"Alberto"},{"first_name":"Ludovic","last_name":"Mallet","full_name":"Mallet, Ludovic"},{"full_name":"Monroy Kuhn, Jose","last_name":"Monroy Kuhn","first_name":"Jose"},{"first_name":"Annabell","full_name":"Moser, Annabell","last_name":"Moser"},{"full_name":"Murali, Shwetha","last_name":"Murali","first_name":"Shwetha"},{"full_name":"Muzny, Donna","last_name":"Muzny","first_name":"Donna"},{"first_name":"Saria","last_name":"Otani","full_name":"Otani, Saria"},{"first_name":"Maria","last_name":"Piulachs","full_name":"Piulachs, Maria"},{"last_name":"Poelchau","full_name":"Poelchau, Monica","first_name":"Monica"},{"first_name":"Jiaxin","last_name":"Qu","full_name":"Qu, Jiaxin"},{"first_name":"Florentine","last_name":"Schaub","full_name":"Schaub, Florentine"},{"last_name":"Wada Katsumata","full_name":"Wada Katsumata, Ayako","first_name":"Ayako"},{"last_name":"Worley","full_name":"Worley, Kim","first_name":"Kim"},{"last_name":"Xie","full_name":"Xie, Qiaolin","first_name":"Qiaolin"},{"last_name":"Ylla","full_name":"Ylla, Guillem","first_name":"Guillem"},{"full_name":"Poulsen, Michael","last_name":"Poulsen","first_name":"Michael"},{"first_name":"Richard","full_name":"Gibbs, Richard","last_name":"Gibbs"},{"first_name":"Coby","full_name":"Schal, Coby","last_name":"Schal"},{"full_name":"Richards, Stephen","last_name":"Richards","first_name":"Stephen"},{"first_name":"Xavier","last_name":"Belles","full_name":"Belles, Xavier"},{"first_name":"Judith","full_name":"Korb, Judith","last_name":"Korb"},{"full_name":"Bornberg Bauer, Erich","last_name":"Bornberg Bauer","first_name":"Erich"}],"day":"05","scopus_import":"1","date_created":"2018-12-11T11:46:32Z","volume":2,"tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","short":"CC BY (4.0)"},"abstract":[{"text":"Around 150 million years ago, eusocial termites evolved from within the cockroaches, 50 million years before eusocial Hymenoptera, such as bees and ants, appeared. Here, we report the 2-Gb genome of the German cockroach, Blattella germanica, and the 1.3-Gb genome of the drywood termite Cryptotermes secundus. We show evolutionary signatures of termite eusociality by comparing the genomes and transcriptomes of three termites and the cockroach against the background of 16 other eusocial and non-eusocial insects. Dramatic adaptive changes in genes underlying the production and perception of pheromones confirm the importance of chemical communication in the termites. These are accompanied by major changes in gene regulation and the molecular evolution of caste determination. Many of these results parallel molecular mechanisms of eusocial evolution in Hymenoptera. However, the specific solutions are remarkably different, thus revealing a striking case of convergence in one of the major evolutionary transitions in biological complexity.","lang":"eng"}],"intvolume":"         2","has_accepted_license":"1","publication_status":"published","file_date_updated":"2020-07-14T12:46:30Z"},{"date_published":"2017-07-06T00:00:00Z","project":[{"grant_number":"P28842-B22","name":"Sex chromosome evolution under male- and female- heterogamety","call_identifier":"FWF","_id":"250ED89C-B435-11E9-9278-68D0E5697425"}],"publication":"Molecular Biology and Evolution","status":"public","publist_id":"6472","external_id":{"isi":["000411814800016"]},"year":"2017","isi":1,"quality_controlled":"1","ddc":["570","576"],"page":"2637 - 2649","type":"journal_article","date_updated":"2023-09-26T15:36:34Z","_id":"945","publisher":"Oxford University Press","doi":"10.1093/molbev/msx190","article_processing_charge":"Yes (in subscription journal)","user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1","issue":"10","citation":{"short":"A.K. Huylmans, A. Macon, B. Vicoso, Molecular Biology and Evolution 34 (2017) 2637–2649.","ieee":"A. K. Huylmans, A. Macon, and B. Vicoso, “Global dosage compensation is ubiquitous in Lepidoptera, but counteracted by the masculinization of the Z chromosome,” <i>Molecular Biology and Evolution</i>, vol. 34, no. 10. Oxford University Press, pp. 2637–2649, 2017.","ama":"Huylmans AK, Macon A, Vicoso B. Global dosage compensation is ubiquitous in Lepidoptera, but counteracted by the masculinization of the Z chromosome. <i>Molecular Biology and Evolution</i>. 2017;34(10):2637-2649. doi:<a href=\"https://doi.org/10.1093/molbev/msx190\">10.1093/molbev/msx190</a>","mla":"Huylmans, Ann K., et al. “Global Dosage Compensation Is Ubiquitous in Lepidoptera, but Counteracted by the Masculinization of the Z Chromosome.” <i>Molecular Biology and Evolution</i>, vol. 34, no. 10, Oxford University Press, 2017, pp. 2637–49, doi:<a href=\"https://doi.org/10.1093/molbev/msx190\">10.1093/molbev/msx190</a>.","apa":"Huylmans, A. K., Macon, A., &#38; Vicoso, B. (2017). Global dosage compensation is ubiquitous in Lepidoptera, but counteracted by the masculinization of the Z chromosome. <i>Molecular Biology and Evolution</i>. Oxford University Press. <a href=\"https://doi.org/10.1093/molbev/msx190\">https://doi.org/10.1093/molbev/msx190</a>","ista":"Huylmans AK, Macon A, Vicoso B. 2017. Global dosage compensation is ubiquitous in Lepidoptera, but counteracted by the masculinization of the Z chromosome. Molecular Biology and Evolution. 34(10), 2637–2649.","chicago":"Huylmans, Ann K, Ariana Macon, and Beatriz Vicoso. “Global Dosage Compensation Is Ubiquitous in Lepidoptera, but Counteracted by the Masculinization of the Z Chromosome.” <i>Molecular Biology and Evolution</i>. Oxford University Press, 2017. <a href=\"https://doi.org/10.1093/molbev/msx190\">https://doi.org/10.1093/molbev/msx190</a>."},"language":[{"iso":"eng"}],"pubrep_id":"848","oa":1,"file":[{"checksum":"009fd68043211d645ceb9d1de28274f2","relation":"main_file","content_type":"application/pdf","access_level":"open_access","file_name":"IST-2017-848-v1+1_2017_Vicoso_GlobalDosage.pdf","file_id":"4810","date_updated":"2020-07-14T12:48:15Z","creator":"system","date_created":"2018-12-12T10:10:23Z","file_size":462863}],"department":[{"_id":"BeVi"}],"month":"07","publication_identifier":{"issn":["07374038"]},"publication_status":"published","file_date_updated":"2020-07-14T12:48:15Z","abstract":[{"lang":"eng","text":"While chromosome-wide dosage compensation of the X chromosome has been found in many species, studies in ZW clades have indicated that compensation of the Z is more localized and/or incomplete. In the ZW Lepidoptera, some species show complete compensation of the Z chromosome, while others lack full equalization, but what drives these inconsistencies is unclear. Here, we compare patterns of male and female gene expression on the Z chromosome of two closely related butterfly species, Papilio xuthus and Papilio machaon, and in multiple tissues of two moths species, Plodia interpunctella and Bombyx mori, which were previously found to differ in the extent to which they equalize Z-linked gene expression between the sexes. We find that, while some species and tissues seem to have incomplete dosage compensation, this is in fact due to the accumulation of male-biased genes and the depletion of female-biased genes on the Z chromosome. Once this is accounted for, the Z chromosome is fully compensated in all four species, through the up-regulation of Z expression in females and in some cases additional down-regulation in males. We further find that both sex-biased genes and Z-linked genes have increased rates of expression divergence in this clade, and that this can lead to fast shifts in patterns of gene expression even between closely related species. Taken together, these results show that the uneven distribution of sex-biased genes on sex chromosomes can confound conclusions about dosage compensation and that Z chromosome-wide dosage compensation is not only possible but ubiquitous among Lepidoptera."}],"tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","short":"CC BY (4.0)"},"intvolume":"        34","has_accepted_license":"1","date_created":"2018-12-11T11:49:20Z","volume":34,"oa_version":"Published Version","title":"Global dosage compensation is ubiquitous in Lepidoptera, but counteracted by the masculinization of the Z chromosome","author":[{"first_name":"Ann K","orcid":"0000-0001-8871-4961","full_name":"Huylmans, Ann K","id":"4C0A3874-F248-11E8-B48F-1D18A9856A87","last_name":"Huylmans"},{"first_name":"Ariana","last_name":"Macon","full_name":"Macon, Ariana","id":"2A0848E2-F248-11E8-B48F-1D18A9856A87"},{"orcid":"0000-0002-4579-8306","first_name":"Beatriz","full_name":"Vicoso, Beatriz","id":"49E1C5C6-F248-11E8-B48F-1D18A9856A87","last_name":"Vicoso"}],"day":"06","scopus_import":"1"},{"oa_version":"None","title":"X-linkage is not a general inhibitor of tissue-specific gene expression in Drosophila melanogaster","author":[{"last_name":"Argyridou","full_name":"Argyridou, Eliza","first_name":"Eliza"},{"id":"4C0A3874-F248-11E8-B48F-1D18A9856A87","full_name":"Huylmans, Ann K","last_name":"Huylmans","first_name":"Ann K","orcid":"0000-0001-8871-4961"},{"last_name":"Königer","full_name":"Königer, Annabella","first_name":"Annabella"},{"last_name":"Parsch","full_name":"Parsch, John","first_name":"John"}],"day":"01","scopus_import":"1","date_created":"2018-12-11T11:49:43Z","volume":119,"intvolume":"       119","abstract":[{"lang":"eng","text":"As a consequence of its difference in copy number between males and females, the X chromosome is subject to unique evolutionary forces and gene regulatory mechanisms. Previous studies of Drosophila melanogaster have shown that the expression of X-linked, testis-specific reporter genes is suppressed in the male germline. However, it is not known whether this phenomenon is restricted to testis-expressed genes or if it is a more general property of genes with tissue-specific expression, which are also underrepresented on the X chromosome. To test this, we compared the expression of three tissue-specific reporter genes (ovary, accessory gland and Malpighian tubule) inserted at various autosomal and X-chromosomal locations. In contrast to testis-specific reporter genes, we found no reduction of X-linked expression in any of the other tissues. In accessory gland and Malpighian tubule, we detected higher expression of the X-linked reporter genes, which suggests that they are at least partially dosage compensated. We found no difference in the tissue-specificity of X-linked and autosomal reporter genes. These findings indicate that, in general, the X chromosome is not a detrimental environment for tissue-specific gene expression and that the suppression of X-linked expression is limited to the male germline."}],"publication_status":"published","publication_identifier":{"issn":["0018067X"]},"month":"07","department":[{"_id":"BeVi"}],"language":[{"iso":"eng"}],"user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1","issue":"1","citation":{"mla":"Argyridou, Eliza, et al. “X-Linkage Is Not a General Inhibitor of Tissue-Specific Gene Expression in Drosophila Melanogaster.” <i>Heredity</i>, vol. 119, no. 1, Nature Publishing Group, 2017, pp. 27–34, doi:<a href=\"https://doi.org/10.1038/hdy.2017.12\">10.1038/hdy.2017.12</a>.","apa":"Argyridou, E., Huylmans, A. K., Königer, A., &#38; Parsch, J. (2017). X-linkage is not a general inhibitor of tissue-specific gene expression in Drosophila melanogaster. <i>Heredity</i>. Nature Publishing Group. <a href=\"https://doi.org/10.1038/hdy.2017.12\">https://doi.org/10.1038/hdy.2017.12</a>","ista":"Argyridou E, Huylmans AK, Königer A, Parsch J. 2017. X-linkage is not a general inhibitor of tissue-specific gene expression in Drosophila melanogaster. Heredity. 119(1), 27–34.","chicago":"Argyridou, Eliza, Ann K Huylmans, Annabella Königer, and John Parsch. “X-Linkage Is Not a General Inhibitor of Tissue-Specific Gene Expression in Drosophila Melanogaster.” <i>Heredity</i>. Nature Publishing Group, 2017. <a href=\"https://doi.org/10.1038/hdy.2017.12\">https://doi.org/10.1038/hdy.2017.12</a>.","short":"E. Argyridou, A.K. Huylmans, A. Königer, J. Parsch, Heredity 119 (2017) 27–34.","ieee":"E. Argyridou, A. K. Huylmans, A. Königer, and J. Parsch, “X-linkage is not a general inhibitor of tissue-specific gene expression in Drosophila melanogaster,” <i>Heredity</i>, vol. 119, no. 1. Nature Publishing Group, pp. 27–34, 2017.","ama":"Argyridou E, Huylmans AK, Königer A, Parsch J. X-linkage is not a general inhibitor of tissue-specific gene expression in Drosophila melanogaster. <i>Heredity</i>. 2017;119(1):27-34. doi:<a href=\"https://doi.org/10.1038/hdy.2017.12\">10.1038/hdy.2017.12</a>"},"publisher":"Nature Publishing Group","doi":"10.1038/hdy.2017.12","article_processing_charge":"No","type":"journal_article","date_updated":"2023-09-22T09:41:21Z","_id":"1019","page":"27 - 34","quality_controlled":"1","external_id":{"isi":["000405397800004"]},"related_material":{"record":[{"id":"9861","relation":"research_data","status":"public"}]},"year":"2017","isi":1,"publist_id":"6374","status":"public","publication":"Heredity","date_published":"2017-07-01T00:00:00Z"},{"title":"Data from: X-linkage is not a general inhibitor of tissue-specific gene expression in Drosophila melanogaster","publisher":"Dryad","oa_version":"Published Version","doi":"10.5061/dryad.02f6r","author":[{"first_name":"Eliza","last_name":"Argyridou","full_name":"Argyridou, Eliza"},{"id":"4C0A3874-F248-11E8-B48F-1D18A9856A87","full_name":"Huylmans, Ann K","last_name":"Huylmans","orcid":"0000-0001-8871-4961","first_name":"Ann K"},{"full_name":"Königer, Annabella","last_name":"Königer","first_name":"Annabella"},{"first_name":"John","full_name":"Parsch, John","last_name":"Parsch"}],"article_processing_charge":"No","day":"14","type":"research_data_reference","date_created":"2021-08-10T08:12:52Z","date_updated":"2023-09-22T09:41:20Z","_id":"9861","abstract":[{"lang":"eng","text":"As a consequence of its difference in copy number between males and females, the X chromosome is subject to unique evolutionary forces and gene regulatory mechanisms. Previous studies of Drosophila melanogaster have shown that the expression of X-linked, testis-specific reporter genes is suppressed in the male germline. However, it is not known whether this phenomenon is restricted to testis-expressed genes or if it is a more general property of genes with tissue-specific expression, which are also underrepresented on the X chromosome. To test this, we compared the expression of three tissue-specific reporter genes (ovary, accessory gland and Malpighian tubule) inserted at various autosomal and X-chromosomal locations. In contrast to testis-specific reporter genes, we found no reduction of X-linked expression in any of the other tissues. In accessory gland and Malpighian tubule, we detected higher expression of the X-linked reporter genes, which suggests that they are at least partially dosage compensated. We found no difference in the tissue-specificity of X-linked and autosomal reporter genes. These findings indicate that, in general, the X chromosome is not a detrimental environment for tissue-specific gene expression and that the suppression of X-linked expression is limited to the male germline."}],"main_file_link":[{"open_access":"1","url":"https://doi.org/10.5061/dryad.02f6r"}],"related_material":{"record":[{"status":"public","relation":"used_in_publication","id":"1019"}]},"month":"02","year":"2017","department":[{"_id":"BeVi"}],"status":"public","oa":1,"date_published":"2017-02-14T00:00:00Z","user_id":"6785fbc1-c503-11eb-8a32-93094b40e1cf","citation":{"ieee":"E. Argyridou, A. K. Huylmans, A. Königer, and J. Parsch, “Data from: X-linkage is not a general inhibitor of tissue-specific gene expression in Drosophila melanogaster.” Dryad, 2017.","short":"E. Argyridou, A.K. Huylmans, A. Königer, J. Parsch, (2017).","ama":"Argyridou E, Huylmans AK, Königer A, Parsch J. Data from: X-linkage is not a general inhibitor of tissue-specific gene expression in Drosophila melanogaster. 2017. doi:<a href=\"https://doi.org/10.5061/dryad.02f6r\">10.5061/dryad.02f6r</a>","apa":"Argyridou, E., Huylmans, A. K., Königer, A., &#38; Parsch, J. (2017). Data from: X-linkage is not a general inhibitor of tissue-specific gene expression in Drosophila melanogaster. Dryad. <a href=\"https://doi.org/10.5061/dryad.02f6r\">https://doi.org/10.5061/dryad.02f6r</a>","mla":"Argyridou, Eliza, et al. <i>Data from: X-Linkage Is Not a General Inhibitor of Tissue-Specific Gene Expression in Drosophila Melanogaster</i>. Dryad, 2017, doi:<a href=\"https://doi.org/10.5061/dryad.02f6r\">10.5061/dryad.02f6r</a>.","ista":"Argyridou E, Huylmans AK, Königer A, Parsch J. 2017. Data from: X-linkage is not a general inhibitor of tissue-specific gene expression in Drosophila melanogaster, Dryad, <a href=\"https://doi.org/10.5061/dryad.02f6r\">10.5061/dryad.02f6r</a>.","chicago":"Argyridou, Eliza, Ann K Huylmans, Annabella Königer, and John Parsch. “Data from: X-Linkage Is Not a General Inhibitor of Tissue-Specific Gene Expression in Drosophila Melanogaster.” Dryad, 2017. <a href=\"https://doi.org/10.5061/dryad.02f6r\">https://doi.org/10.5061/dryad.02f6r</a>."}},{"publist_id":"5940","year":"2016","acknowledgement":"This study was financially supported by individual grants from the Volkswagen Stiftung (to M.C.), the Deutsche Forschungsgemeinschaft (grant PA 903/6 to J.P.) and the DAAD (to A.K.H.). The authors would like to thank I. Schrank, L. Theodosiou, M. Kredler, C. Laforsch, J. Wolinska, J. Griebel, R. Jaenichen, and K. Otte for providing the necessary resources and help for maintaining Daphnia cultures in the laboratory. H. Lainer supported us for the molecular laboratory work. D. Gilbert and J. K. Colbourne contributed ideas for the bioinformatics analysis, and L. Hardulak did the orthology mapping including more insect species. This study was financially supported by individual grants from the Volkswagen Stiftung (to M.C.), the Deutsche Forschungsgemeinschaft (grant PA 903/6 to J.P.) and the DAAD (to A.K.H.). This work benefits from and contributes to the Daphnia Genomics Consortium.","date_published":"2016-10-01T00:00:00Z","publication":"Genome Biology and Evolution","status":"public","date_updated":"2021-01-12T06:49:55Z","_id":"1329","type":"journal_article","doi":"10.1093/gbe/evw221","publisher":"Oxford University Press","quality_controlled":"1","page":"3120 - 3139","ddc":["576"],"department":[{"_id":"BeVi"}],"file":[{"access_level":"open_access","content_type":"application/pdf","file_name":"IST-2016-663-v1+1_Genome_Biol_Evol-2016-Huylmans-3120-39.pdf","checksum":"25c7adcb452d39d3b6343ff4b57a652d","relation":"main_file","date_updated":"2020-07-14T12:44:44Z","creator":"system","file_size":1406265,"date_created":"2018-12-12T10:12:06Z","file_id":"4924"}],"month":"10","issue":"10","citation":{"chicago":"Huylmans, Ann K, Alberto López Ezquerra, John Parsch, and Mathilde Cordellier. “De Novo Transcriptome Assembly and Sex-Biased Gene Expression in the Cyclical Parthenogenetic Daphnia Galeata.” <i>Genome Biology and Evolution</i>. Oxford University Press, 2016. <a href=\"https://doi.org/10.1093/gbe/evw221\">https://doi.org/10.1093/gbe/evw221</a>.","ista":"Huylmans AK, López Ezquerra A, Parsch J, Cordellier M. 2016. De novo transcriptome assembly and sex-biased gene expression in the cyclical parthenogenetic Daphnia galeata. Genome Biology and Evolution. 8(10), 3120–3139.","mla":"Huylmans, Ann K., et al. “De Novo Transcriptome Assembly and Sex-Biased Gene Expression in the Cyclical Parthenogenetic Daphnia Galeata.” <i>Genome Biology and Evolution</i>, vol. 8, no. 10, Oxford University Press, 2016, pp. 3120–39, doi:<a href=\"https://doi.org/10.1093/gbe/evw221\">10.1093/gbe/evw221</a>.","apa":"Huylmans, A. K., López Ezquerra, A., Parsch, J., &#38; Cordellier, M. (2016). De novo transcriptome assembly and sex-biased gene expression in the cyclical parthenogenetic Daphnia galeata. <i>Genome Biology and Evolution</i>. Oxford University Press. <a href=\"https://doi.org/10.1093/gbe/evw221\">https://doi.org/10.1093/gbe/evw221</a>","ama":"Huylmans AK, López Ezquerra A, Parsch J, Cordellier M. De novo transcriptome assembly and sex-biased gene expression in the cyclical parthenogenetic Daphnia galeata. <i>Genome Biology and Evolution</i>. 2016;8(10):3120-3139. doi:<a href=\"https://doi.org/10.1093/gbe/evw221\">10.1093/gbe/evw221</a>","short":"A.K. Huylmans, A. López Ezquerra, J. Parsch, M. Cordellier, Genome Biology and Evolution 8 (2016) 3120–3139.","ieee":"A. K. Huylmans, A. López Ezquerra, J. Parsch, and M. Cordellier, “De novo transcriptome assembly and sex-biased gene expression in the cyclical parthenogenetic Daphnia galeata,” <i>Genome Biology and Evolution</i>, vol. 8, no. 10. Oxford University Press, pp. 3120–3139, 2016."},"user_id":"3E5EF7F0-F248-11E8-B48F-1D18A9856A87","oa":1,"language":[{"iso":"eng"}],"pubrep_id":"663","volume":8,"date_created":"2018-12-11T11:51:24Z","author":[{"full_name":"Huylmans, Ann K","id":"4C0A3874-F248-11E8-B48F-1D18A9856A87","last_name":"Huylmans","first_name":"Ann K","orcid":"0000-0001-8871-4961"},{"first_name":"Alberto","full_name":"López Ezquerra, Alberto","last_name":"López Ezquerra"},{"last_name":"Parsch","full_name":"Parsch, John","first_name":"John"},{"first_name":"Mathilde","full_name":"Cordellier, Mathilde","last_name":"Cordellier"}],"scopus_import":1,"day":"01","oa_version":"Published Version","title":"De novo transcriptome assembly and sex-biased gene expression in the cyclical parthenogenetic Daphnia galeata","publication_status":"published","file_date_updated":"2020-07-14T12:44:44Z","has_accepted_license":"1","tmp":{"name":"Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)","legal_code_url":"https://creativecommons.org/licenses/by-nc/4.0/legalcode","image":"/images/cc_by_nc.png","short":"CC BY-NC (4.0)"},"intvolume":"         8","abstract":[{"text":"Daphnia species have become models for ecological genomics and exhibit interesting features, such as high phenotypic plasticity and a densely packed genome with many lineage-specific genes. They are also cyclic parthenogenetic, with alternating asexual and sexual cycles and environmental sex determination. Here, we present a de novo transcriptome assembly of over 32,000 D. galeata genes and use it to investigate gene expression in females and spontaneously produced males of two clonal lines derived from lakes in Germany and the Czech Republic. We find that only a low percentage (18%) of genes shows sex-biased expression and that there are many more female-biased gene (FBG) than male-biased gene (MBG). Furthermore, FBGs tend to be more conserved between species than MBGs in both sequence and expression. These patterns may be a consequence of cyclic parthenogenesis leading to a relaxation of purifying selection on MBGs. The two clonal lines show considerable differences in both number and identity of sex-biased genes, suggesting that they may have reproductive strategies differing in their investment in sexual reproduction. Orthologs of key genes in the sex determination and juvenile hormone pathways, which are thought to be important for the transition from asexual to sexual reproduction, are present in D. galeata and highly conserved among Daphnia species.","lang":"eng"}]}]