---
_id: '320'
abstract:
- lang: eng
  text: 'Fast-spiking, parvalbumin-expressing GABAergic interneurons (PV+-BCs) express
    a complex machinery of rapid signaling mechanisms, including specialized voltage-gated
    ion channels to generate brief action potentials (APs). However, short APs are
    associated with overlapping Na+ and K+ fluxes and are therefore energetically
    expensive. How the potentially vicious combination of high AP frequency and inefficient
    spike generation can be reconciled with limited energy supply is presently unclear.
    To address this question, we performed direct recordings from the PV+-BC axon,
    the subcellular structure where active conductances for AP initiation and propagation
    are located. Surprisingly, the energy required for the AP was, on average, only
    ∼1.6 times the theoretical minimum. High energy efficiency emerged from the combination
    of fast inactivation of Na+ channels and delayed activation of Kv3-type K+ channels,
    which minimized ion flux overlap during APs. Thus, the complementary tuning of
    axonal Na+ and K+ channel gating optimizes both fast signaling properties and
    metabolic efficiency. Hu et al. demonstrate that action potentials in parvalbumin-expressing
    GABAergic interneuron axons are energetically efficient, which is highly unexpected
    given their brief duration. High energy efficiency emerges from the combination
    of fast inactivation of voltage-gated Na+ channels and delayed activation of Kv3
    channels in the axon. '
article_processing_charge: Yes (in subscription journal)
author:
- first_name: Hua
  full_name: Hu, Hua
  id: 4AC0145C-F248-11E8-B48F-1D18A9856A87
  last_name: Hu
- first_name: Fabian
  full_name: Roth, Fabian
  last_name: Roth
- first_name: David H
  full_name: Vandael, David H
  id: 3AE48E0A-F248-11E8-B48F-1D18A9856A87
  last_name: Vandael
  orcid: 0000-0001-7577-1676
- first_name: Peter M
  full_name: Jonas, Peter M
  id: 353C1B58-F248-11E8-B48F-1D18A9856A87
  last_name: Jonas
  orcid: 0000-0001-5001-4804
citation:
  ama: Hu H, Roth F, Vandael DH, Jonas PM. Complementary tuning of Na+ and K+ channel
    gating underlies fast and energy-efficient action potentials in GABAergic interneuron
    axons. <i>Neuron</i>. 2018;98(1):156-165. doi:<a href="https://doi.org/10.1016/j.neuron.2018.02.024">10.1016/j.neuron.2018.02.024</a>
  apa: Hu, H., Roth, F., Vandael, D. H., &#38; Jonas, P. M. (2018). Complementary
    tuning of Na+ and K+ channel gating underlies fast and energy-efficient action
    potentials in GABAergic interneuron axons. <i>Neuron</i>. Elsevier. <a href="https://doi.org/10.1016/j.neuron.2018.02.024">https://doi.org/10.1016/j.neuron.2018.02.024</a>
  chicago: Hu, Hua, Fabian Roth, David H Vandael, and Peter M Jonas. “Complementary
    Tuning of Na+ and K+ Channel Gating Underlies Fast and Energy-Efficient Action
    Potentials in GABAergic Interneuron Axons.” <i>Neuron</i>. Elsevier, 2018. <a
    href="https://doi.org/10.1016/j.neuron.2018.02.024">https://doi.org/10.1016/j.neuron.2018.02.024</a>.
  ieee: H. Hu, F. Roth, D. H. Vandael, and P. M. Jonas, “Complementary tuning of Na+
    and K+ channel gating underlies fast and energy-efficient action potentials in
    GABAergic interneuron axons,” <i>Neuron</i>, vol. 98, no. 1. Elsevier, pp. 156–165,
    2018.
  ista: Hu H, Roth F, Vandael DH, Jonas PM. 2018. Complementary tuning of Na+ and
    K+ channel gating underlies fast and energy-efficient action potentials in GABAergic
    interneuron axons. Neuron. 98(1), 156–165.
  mla: Hu, Hua, et al. “Complementary Tuning of Na+ and K+ Channel Gating Underlies
    Fast and Energy-Efficient Action Potentials in GABAergic Interneuron Axons.” <i>Neuron</i>,
    vol. 98, no. 1, Elsevier, 2018, pp. 156–65, doi:<a href="https://doi.org/10.1016/j.neuron.2018.02.024">10.1016/j.neuron.2018.02.024</a>.
  short: H. Hu, F. Roth, D.H. Vandael, P.M. Jonas, Neuron 98 (2018) 156–165.
date_created: 2018-12-11T11:45:48Z
date_published: 2018-04-04T00:00:00Z
date_updated: 2023-09-11T12:45:10Z
day: '04'
ddc:
- '570'
department:
- _id: PeJo
doi: 10.1016/j.neuron.2018.02.024
ec_funded: 1
external_id:
  isi:
  - '000429192100016'
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oa: 1
oa_version: Published Version
page: 156 - 165
project:
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  call_identifier: FP7
  grant_number: '268548'
  name: Nanophysiology of fast-spiking, parvalbumin-expressing GABAergic interneurons
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  grant_number: '692692'
  name: Biophysics and circuit function of a giant cortical glumatergic synapse
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  call_identifier: FWF
  grant_number: P24909-B24
  name: Mechanisms of transmitter release at GABAergic synapses
- _id: 25C5A090-B435-11E9-9278-68D0E5697425
  call_identifier: FWF
  grant_number: Z00312
  name: The Wittgenstein Prize
publication: Neuron
publication_status: published
publisher: Elsevier
publist_id: '7545'
quality_controlled: '1'
related_material:
  link:
  - description: News on IST Homepage
    relation: press_release
    url: https://ist.ac.at/en/news/a-certain-type-of-neurons-is-more-energy-efficient-than-previously-assumed/
scopus_import: '1'
status: public
title: Complementary tuning of Na+ and K+ channel gating underlies fast and energy-efficient
  action potentials in GABAergic interneuron axons
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 98
year: '2018'
...
---
_id: '2062'
abstract:
- lang: eng
  text: The success story of fast-spiking, parvalbumin-positive (PV+) GABAergic interneurons
    (GABA, γ-aminobutyric acid) in the mammalian central nervous system is noteworthy.
    In 1995, the properties of these interneurons were completely unknown. Twenty
    years later, thanks to the massive use of subcellular patch-clamp techniques,
    simultaneous multiple-cell recording, optogenetics, in vivo measurements, and
    computational approaches, our knowledge about PV+ interneurons became more extensive
    than for several types of pyramidal neurons. These findings have implications
    beyond the “small world” of basic research on GABAergic cells. For example, the
    results provide a first proof of principle that neuroscientists might be able
    to close the gaps between the molecular, cellular, network, and behavioral levels,
    representing one of the main challenges at the present time. Furthermore, the
    results may form the basis for PV+ interneurons as therapeutic targets for brain
    disease in the future. However, much needs to be learned about the basic function
    of these interneurons before clinical neuroscientists will be able to use PV+
    interneurons for therapeutic purposes.
article_number: '1255263'
author:
- first_name: Hua
  full_name: Hu, Hua
  id: 4AC0145C-F248-11E8-B48F-1D18A9856A87
  last_name: Hu
- first_name: Jian
  full_name: Gan, Jian
  id: 3614E438-F248-11E8-B48F-1D18A9856A87
  last_name: Gan
- first_name: Peter M
  full_name: Jonas, Peter M
  id: 353C1B58-F248-11E8-B48F-1D18A9856A87
  last_name: Jonas
  orcid: 0000-0001-5001-4804
citation:
  ama: 'Hu H, Gan J, Jonas PM. Fast-spiking parvalbumin^+ GABAergic interneurons:
    From cellular design to microcircuit function. <i>Science</i>. 2014;345(6196).
    doi:<a href="https://doi.org/10.1126/science.1255263">10.1126/science.1255263</a>'
  apa: 'Hu, H., Gan, J., &#38; Jonas, P. M. (2014). Fast-spiking parvalbumin^+ GABAergic
    interneurons: From cellular design to microcircuit function. <i>Science</i>. American
    Association for the Advancement of Science. <a href="https://doi.org/10.1126/science.1255263">https://doi.org/10.1126/science.1255263</a>'
  chicago: 'Hu, Hua, Jian Gan, and Peter M Jonas. “Fast-Spiking Parvalbumin^+ GABAergic
    Interneurons: From Cellular Design to Microcircuit Function.” <i>Science</i>.
    American Association for the Advancement of Science, 2014. <a href="https://doi.org/10.1126/science.1255263">https://doi.org/10.1126/science.1255263</a>.'
  ieee: 'H. Hu, J. Gan, and P. M. Jonas, “Fast-spiking parvalbumin^+ GABAergic interneurons:
    From cellular design to microcircuit function,” <i>Science</i>, vol. 345, no.
    6196. American Association for the Advancement of Science, 2014.'
  ista: 'Hu H, Gan J, Jonas PM. 2014. Fast-spiking parvalbumin^+ GABAergic interneurons:
    From cellular design to microcircuit function. Science. 345(6196), 1255263.'
  mla: 'Hu, Hua, et al. “Fast-Spiking Parvalbumin^+ GABAergic Interneurons: From Cellular
    Design to Microcircuit Function.” <i>Science</i>, vol. 345, no. 6196, 1255263,
    American Association for the Advancement of Science, 2014, doi:<a href="https://doi.org/10.1126/science.1255263">10.1126/science.1255263</a>.'
  short: H. Hu, J. Gan, P.M. Jonas, Science 345 (2014).
date_created: 2018-12-11T11:55:29Z
date_published: 2014-08-01T00:00:00Z
date_updated: 2021-01-12T06:55:03Z
day: '01'
ddc:
- '570'
department:
- _id: PeJo
doi: 10.1126/science.1255263
ec_funded: 1
file:
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  checksum: a0036a589037d37e86364fa25cc0a82f
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  file_id: '5185'
  file_name: IST-2017-821-v1+1_1255263JonasPVReviewTextR_Final.pdf
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  file_name: IST-2017-821-v1+2_1255263JonasPVReviewFigures_Final.pdf
  file_size: 1732723
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has_accepted_license: '1'
intvolume: '       345'
issue: '6196'
language:
- iso: eng
month: '08'
oa: 1
oa_version: Submitted Version
project:
- _id: 25C26B1E-B435-11E9-9278-68D0E5697425
  call_identifier: FWF
  grant_number: P24909-B24
  name: Mechanisms of transmitter release at GABAergic synapses
- _id: 25C0F108-B435-11E9-9278-68D0E5697425
  call_identifier: FP7
  grant_number: '268548'
  name: Nanophysiology of fast-spiking, parvalbumin-expressing GABAergic interneurons
publication: Science
publication_status: published
publisher: American Association for the Advancement of Science
publist_id: '4984'
pubrep_id: '821'
quality_controlled: '1'
scopus_import: 1
status: public
title: 'Fast-spiking parvalbumin^+ GABAergic interneurons: From cellular design to
  microcircuit function'
type: journal_article
user_id: 4435EBFC-F248-11E8-B48F-1D18A9856A87
volume: 345
year: '2014'
...
---
_id: '2228'
abstract:
- lang: eng
  text: Fast-spiking, parvalbumin-expressing GABAergic interneurons, a large proportion
    of which are basket cells (BCs), have a key role in feedforward and feedback inhibition,
    gamma oscillations and complex information processing. For these functions, fast
    propagation of action potentials (APs) from the soma to the presynaptic terminals
    is important. However, the functional properties of interneuron axons remain elusive.
    We examined interneuron axons by confocally targeted subcellular patch-clamp recording
    in rat hippocampal slices. APs were initiated in the proximal axon ∼20 μm from
    the soma and propagated to the distal axon with high reliability and speed. Subcellular
    mapping revealed a stepwise increase of Na^+ conductance density from the soma
    to the proximal axon, followed by a further gradual increase in the distal axon.
    Active cable modeling and experiments with partial channel block revealed that
    low axonal Na^+ conductance density was sufficient for reliability, but high Na^+
    density was necessary for both speed of propagation and fast-spiking AP phenotype.
    Our results suggest that a supercritical density of Na^+ channels compensates
    for the morphological properties of interneuron axons (small segmental diameter,
    extensive branching and high bouton density), ensuring fast AP propagation and
    high-frequency repetitive firing.
author:
- first_name: Hua
  full_name: Hu, Hua
  id: 4AC0145C-F248-11E8-B48F-1D18A9856A87
  last_name: Hu
- first_name: Peter M
  full_name: Jonas, Peter M
  id: 353C1B58-F248-11E8-B48F-1D18A9856A87
  last_name: Jonas
  orcid: 0000-0001-5001-4804
citation:
  ama: Hu H, Jonas PM. A supercritical density of Na^+ channels ensures fast signaling
    in GABAergic interneuron axons. <i>Nature Neuroscience</i>. 2014;17(5):686-693.
    doi:<a href="https://doi.org/10.1038/nn.3678">10.1038/nn.3678</a>
  apa: Hu, H., &#38; Jonas, P. M. (2014). A supercritical density of Na^+ channels
    ensures fast signaling in GABAergic interneuron axons. <i>Nature Neuroscience</i>.
    Nature Publishing Group. <a href="https://doi.org/10.1038/nn.3678">https://doi.org/10.1038/nn.3678</a>
  chicago: Hu, Hua, and Peter M Jonas. “A Supercritical Density of Na^+ Channels Ensures
    Fast Signaling in GABAergic Interneuron Axons.” <i>Nature Neuroscience</i>. Nature
    Publishing Group, 2014. <a href="https://doi.org/10.1038/nn.3678">https://doi.org/10.1038/nn.3678</a>.
  ieee: H. Hu and P. M. Jonas, “A supercritical density of Na^+ channels ensures fast
    signaling in GABAergic interneuron axons,” <i>Nature Neuroscience</i>, vol. 17,
    no. 5. Nature Publishing Group, pp. 686–693, 2014.
  ista: Hu H, Jonas PM. 2014. A supercritical density of Na^+ channels ensures fast
    signaling in GABAergic interneuron axons. Nature Neuroscience. 17(5), 686–693.
  mla: Hu, Hua, and Peter M. Jonas. “A Supercritical Density of Na^+ Channels Ensures
    Fast Signaling in GABAergic Interneuron Axons.” <i>Nature Neuroscience</i>, vol.
    17, no. 5, Nature Publishing Group, 2014, pp. 686–93, doi:<a href="https://doi.org/10.1038/nn.3678">10.1038/nn.3678</a>.
  short: H. Hu, P.M. Jonas, Nature Neuroscience 17 (2014) 686–693.
date_created: 2018-12-11T11:56:26Z
date_published: 2014-03-23T00:00:00Z
date_updated: 2021-01-12T06:56:08Z
day: '23'
department:
- _id: PeJo
doi: 10.1038/nn.3678
ec_funded: 1
intvolume: '        17'
issue: '5'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4286295/
month: '03'
oa: 1
oa_version: Submitted Version
page: 686-693
project:
- _id: 25C0F108-B435-11E9-9278-68D0E5697425
  call_identifier: FP7
  grant_number: '268548'
  name: Nanophysiology of fast-spiking, parvalbumin-expressing GABAergic interneurons
- _id: 25C26B1E-B435-11E9-9278-68D0E5697425
  call_identifier: FWF
  grant_number: P24909-B24
  name: Mechanisms of transmitter release at GABAergic synapses
publication: Nature Neuroscience
publication_identifier:
  issn:
  - '10976256'
publication_status: published
publisher: Nature Publishing Group
publist_id: '4733'
quality_controlled: '1'
scopus_import: 1
status: public
title: A supercritical density of Na^+ channels ensures fast signaling in GABAergic
  interneuron axons
type: journal_article
user_id: 4435EBFC-F248-11E8-B48F-1D18A9856A87
volume: 17
year: '2014'
...
---
_id: '3258'
abstract:
- lang: eng
  text: CA3 pyramidal neurons are important for memory formation and pattern completion
    in the hippocampal network. It is generally thought that proximal synapses from
    the mossy fibers activate these neurons most efficiently, whereas distal inputs
    from the perforant path have a weaker modulatory influence. We used confocally
    targeted patch-clamp recording from dendrites and axons to map the activation
    of rat CA3 pyramidal neurons at the subcellular level. Our results reveal two
    distinct dendritic domains. In the proximal domain, action potentials initiated
    in the axon backpropagate actively with large amplitude and fast time course.
    In the distal domain, Na+ channel–mediated dendritic spikes are efficiently initiated
    by waveforms mimicking synaptic events. CA3 pyramidal neuron dendrites showed
    a high Na+-to-K+ conductance density ratio, providing ideal conditions for active
    backpropagation and dendritic spike initiation. Dendritic spikes may enhance the
    computational power of CA3 pyramidal neurons in the hippocampal network.
acknowledgement: This work was supported by the Deutsche Forschungsgemeinschaft (TR
  3/B10) and the European Union (European Research Council Advanced grant to P.J.).
article_processing_charge: No
article_type: original
author:
- first_name: Sooyun
  full_name: Kim, Sooyun
  id: 394AB1C8-F248-11E8-B48F-1D18A9856A87
  last_name: Kim
- first_name: José
  full_name: Guzmán, José
  id: 30CC5506-F248-11E8-B48F-1D18A9856A87
  last_name: Guzmán
  orcid: 0000-0003-2209-5242
- first_name: Hua
  full_name: Hu, Hua
  id: 4AC0145C-F248-11E8-B48F-1D18A9856A87
  last_name: Hu
- first_name: Peter M
  full_name: Jonas, Peter M
  id: 353C1B58-F248-11E8-B48F-1D18A9856A87
  last_name: Jonas
  orcid: 0000-0001-5001-4804
citation:
  ama: Kim S, Guzmán J, Hu H, Jonas PM. Active dendrites support efficient initiation
    of dendritic spikes in hippocampal CA3 pyramidal neurons. <i>Nature Neuroscience</i>.
    2012;15(4):600-606. doi:<a href="https://doi.org/10.1038/nn.3060">10.1038/nn.3060</a>
  apa: Kim, S., Guzmán, J., Hu, H., &#38; Jonas, P. M. (2012). Active dendrites support
    efficient initiation of dendritic spikes in hippocampal CA3 pyramidal neurons.
    <i>Nature Neuroscience</i>. Nature Publishing Group. <a href="https://doi.org/10.1038/nn.3060">https://doi.org/10.1038/nn.3060</a>
  chicago: Kim, Sooyun, José Guzmán, Hua Hu, and Peter M Jonas. “Active Dendrites
    Support Efficient Initiation of Dendritic Spikes in Hippocampal CA3 Pyramidal
    Neurons.” <i>Nature Neuroscience</i>. Nature Publishing Group, 2012. <a href="https://doi.org/10.1038/nn.3060">https://doi.org/10.1038/nn.3060</a>.
  ieee: S. Kim, J. Guzmán, H. Hu, and P. M. Jonas, “Active dendrites support efficient
    initiation of dendritic spikes in hippocampal CA3 pyramidal neurons,” <i>Nature
    Neuroscience</i>, vol. 15, no. 4. Nature Publishing Group, pp. 600–606, 2012.
  ista: Kim S, Guzmán J, Hu H, Jonas PM. 2012. Active dendrites support efficient
    initiation of dendritic spikes in hippocampal CA3 pyramidal neurons. Nature Neuroscience.
    15(4), 600–606.
  mla: Kim, Sooyun, et al. “Active Dendrites Support Efficient Initiation of Dendritic
    Spikes in Hippocampal CA3 Pyramidal Neurons.” <i>Nature Neuroscience</i>, vol.
    15, no. 4, Nature Publishing Group, 2012, pp. 600–06, doi:<a href="https://doi.org/10.1038/nn.3060">10.1038/nn.3060</a>.
  short: S. Kim, J. Guzmán, H. Hu, P.M. Jonas, Nature Neuroscience 15 (2012) 600–606.
date_created: 2018-12-11T12:02:18Z
date_published: 2012-04-01T00:00:00Z
date_updated: 2023-09-07T11:43:52Z
day: '01'
department:
- _id: PeJo
doi: 10.1038/nn.3060
external_id:
  pmid:
  - '22388958'
intvolume: '        15'
issue: '4'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3617474/
month: '04'
oa: 1
oa_version: Published Version
page: 600 - 606
pmid: 1
project:
- _id: 25BDE9A4-B435-11E9-9278-68D0E5697425
  grant_number: SFB-TR3-TP10B
  name: Glutamaterge synaptische Übertragung und Plastizität in hippocampalen Mikroschaltkreisen
publication: Nature Neuroscience
publication_identifier:
  issn:
  - 1546-1726
publication_status: published
publisher: Nature Publishing Group
publist_id: '3390'
quality_controlled: '1'
related_material:
  record:
  - id: '2964'
    relation: dissertation_contains
    status: public
scopus_import: '1'
status: public
title: Active dendrites support efficient initiation of dendritic spikes in hippocampal
  CA3 pyramidal neurons
type: journal_article
user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
volume: 15
year: '2012'
...
---
_id: '3830'
abstract:
- lang: eng
  text: Fast-spiking, parvalbumin-expressing basket cells (BCs) are important for
    feedforward and feedback inhibition. During network activity, BCs respond with
    short latency and high temporal precision. It is thought that the specific properties
    of input synapses are responsible for rapid recruitment. However, a potential
    contribution of active dendritic conductances has not been addressed. We combined
    confocal imaging and patch-clamp techniques to obtain simultaneous somatodendritic
    recordings from BCs. Action potentials were initiated in the BC axon and backpropagated
    into the dendrites with reduced amplitude and little activity dependence. These
    properties were explained by a high K+ to Na+ conductance ratio in BC dendrites.
    Computational analysis indicated that dendritic K+ channels convey unique integration
    properties to BCs, leading to the rapid and temporally precise activation by excitatory
    inputs.
author:
- first_name: Hua
  full_name: Hua Hu
  id: 4AC0145C-F248-11E8-B48F-1D18A9856A87
  last_name: Hu
- first_name: Marco
  full_name: Martina, Marco
  last_name: Martina
- first_name: Peter M
  full_name: Peter Jonas
  id: 353C1B58-F248-11E8-B48F-1D18A9856A87
  last_name: Jonas
  orcid: 0000-0001-5001-4804
citation:
  ama: Hu H, Martina M, Jonas PM. Dendritic mechanisms underlying rapid synaptic activation
    of fast-spiking hippocampal interneurons. <i>Science</i>. 2010;327(5961):52-58.
    doi:<a href="https://doi.org/10.1126/science.1177876">10.1126/science.1177876</a>
  apa: Hu, H., Martina, M., &#38; Jonas, P. M. (2010). Dendritic mechanisms underlying
    rapid synaptic activation of fast-spiking hippocampal interneurons. <i>Science</i>.
    American Association for the Advancement of Science. <a href="https://doi.org/10.1126/science.1177876">https://doi.org/10.1126/science.1177876</a>
  chicago: Hu, Hua, Marco Martina, and Peter M Jonas. “Dendritic Mechanisms Underlying
    Rapid Synaptic Activation of Fast-Spiking Hippocampal Interneurons.” <i>Science</i>.
    American Association for the Advancement of Science, 2010. <a href="https://doi.org/10.1126/science.1177876">https://doi.org/10.1126/science.1177876</a>.
  ieee: H. Hu, M. Martina, and P. M. Jonas, “Dendritic mechanisms underlying rapid
    synaptic activation of fast-spiking hippocampal interneurons,” <i>Science</i>,
    vol. 327, no. 5961. American Association for the Advancement of Science, pp. 52–8,
    2010.
  ista: Hu H, Martina M, Jonas PM. 2010. Dendritic mechanisms underlying rapid synaptic
    activation of fast-spiking hippocampal interneurons. Science. 327(5961), 52–8.
  mla: Hu, Hua, et al. “Dendritic Mechanisms Underlying Rapid Synaptic Activation
    of Fast-Spiking Hippocampal Interneurons.” <i>Science</i>, vol. 327, no. 5961,
    American Association for the Advancement of Science, 2010, pp. 52–58, doi:<a href="https://doi.org/10.1126/science.1177876">10.1126/science.1177876</a>.
  short: H. Hu, M. Martina, P.M. Jonas, Science 327 (2010) 52–8.
date_created: 2018-12-11T12:05:24Z
date_published: 2010-01-01T00:00:00Z
date_updated: 2021-01-12T07:52:30Z
day: '01'
doi: 10.1126/science.1177876
extern: 1
intvolume: '       327'
issue: '5961'
month: '01'
page: 52 - 8
publication: Science
publication_status: published
publisher: American Association for the Advancement of Science
publist_id: '2381'
quality_controlled: 0
status: public
title: Dendritic mechanisms underlying rapid synaptic activation of fast-spiking hippocampal
  interneurons
type: journal_article
volume: 327
year: '2010'
...
---
_id: '3831'
abstract:
- lang: eng
  text: Fast-spiking, parvalbumin-expressing basket cells (BCs) play a key role in
    feedforward and feedback inhibition in the hippocampus. However, the dendritic
    mechanisms underlying rapid interneuron recruitment have remained unclear. To
    quantitatively address this question, we developed detailed passive cable models
    of BCs in the dentate gyrus based on dual somatic or somatodendritic recordings
    and complete morphologic reconstructions. Both specific membrane capacitance and
    axial resistivity were comparable to those of pyramidal neurons, but the average
    somatodendritic specific membrane resistance (R(m)) was substantially lower in
    BCs. Furthermore, R(m) was markedly nonuniform, being lowest in soma and proximal
    dendrites, intermediate in distal dendrites, and highest in the axon. Thus, the
    somatodendritic gradient of R(m) was the reverse of that in pyramidal neurons.
    Further computational analysis revealed that these unique cable properties accelerate
    the time course of synaptic potentials at the soma in response to fast inputs,
    while boosting the efficacy of slow distal inputs. These properties will facilitate
    both rapid phasic and efficient tonic activation of BCs in hippocampal microcircuits.
author:
- first_name: Anja
  full_name: Norenberg, Anja
  last_name: Norenberg
- first_name: Hua
  full_name: Hua Hu
  id: 4AC0145C-F248-11E8-B48F-1D18A9856A87
  last_name: Hu
- first_name: Imre
  full_name: Vida, Imre
  last_name: Vida
- first_name: Marlene
  full_name: Bartos, Marlene
  last_name: Bartos
- first_name: Peter M
  full_name: Peter Jonas
  id: 353C1B58-F248-11E8-B48F-1D18A9856A87
  last_name: Jonas
  orcid: 0000-0001-5001-4804
citation:
  ama: Norenberg A, Hu H, Vida I, Bartos M, Jonas PM. Distinct nonuniform cable properties
    optimize rapid and efficient activation of fast-spiking GABAergic interneurons.
    <i>PNAS</i>. 2010;107(2):894-899. doi:<a href="https://doi.org/10.1073/pnas.0910716107">10.1073/pnas.0910716107</a>
  apa: Norenberg, A., Hu, H., Vida, I., Bartos, M., &#38; Jonas, P. M. (2010). Distinct
    nonuniform cable properties optimize rapid and efficient activation of fast-spiking
    GABAergic interneurons. <i>PNAS</i>. National Academy of Sciences. <a href="https://doi.org/10.1073/pnas.0910716107">https://doi.org/10.1073/pnas.0910716107</a>
  chicago: Norenberg, Anja, Hua Hu, Imre Vida, Marlene Bartos, and Peter M Jonas.
    “Distinct Nonuniform Cable Properties Optimize Rapid and Efficient Activation
    of Fast-Spiking GABAergic Interneurons.” <i>PNAS</i>. National Academy of Sciences,
    2010. <a href="https://doi.org/10.1073/pnas.0910716107">https://doi.org/10.1073/pnas.0910716107</a>.
  ieee: A. Norenberg, H. Hu, I. Vida, M. Bartos, and P. M. Jonas, “Distinct nonuniform
    cable properties optimize rapid and efficient activation of fast-spiking GABAergic
    interneurons,” <i>PNAS</i>, vol. 107, no. 2. National Academy of Sciences, pp.
    894–9, 2010.
  ista: Norenberg A, Hu H, Vida I, Bartos M, Jonas PM. 2010. Distinct nonuniform cable
    properties optimize rapid and efficient activation of fast-spiking GABAergic interneurons.
    PNAS. 107(2), 894–9.
  mla: Norenberg, Anja, et al. “Distinct Nonuniform Cable Properties Optimize Rapid
    and Efficient Activation of Fast-Spiking GABAergic Interneurons.” <i>PNAS</i>,
    vol. 107, no. 2, National Academy of Sciences, 2010, pp. 894–99, doi:<a href="https://doi.org/10.1073/pnas.0910716107">10.1073/pnas.0910716107</a>.
  short: A. Norenberg, H. Hu, I. Vida, M. Bartos, P.M. Jonas, PNAS 107 (2010) 894–9.
date_created: 2018-12-11T12:05:24Z
date_published: 2010-01-01T00:00:00Z
date_updated: 2021-01-12T07:52:31Z
day: '01'
doi: 10.1073/pnas.0910716107
extern: 1
intvolume: '       107'
issue: '2'
main_file_link:
- open_access: '1'
  url: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2818894/#!po=4.16667
month: '01'
oa: 1
page: 894 - 9
publication: PNAS
publication_status: published
publisher: National Academy of Sciences
publist_id: '2379'
quality_controlled: 0
status: public
title: Distinct nonuniform cable properties optimize rapid and efficient activation
  of fast-spiking GABAergic interneurons
type: journal_article
volume: 107
year: '2010'
...