---
_id: '14784'
abstract:
- lang: eng
  text: The next steps of deep space exploration are manned missions to Moon and Mars.
    For safe space missions for crew members, it is important to understand the impact
    of space flight on the immune system. We studied the effects of 21 days dry immersion
    (DI) exposure on the transcriptomes of T cells isolated from blood samples of
    eight healthy volunteers. Samples were collected 7 days before DI, at day 7, 14,
    and 21 during DI, and 7 days after DI. RNA sequencing of CD3+T cells revealed
    transcriptional alterations across all time points, with most changes occurring
    14 days after DI exposure. At day 21, T cells showed evidence of adaptation with
    a transcriptional profile resembling that of 7 days before DI. At 7 days after
    DI, T cells again changed their transcriptional profile. These data suggest that
    T cells adapt by rewiring their transcriptomes in response to simulated weightlessness
    and that remodeling cues persist when reexposed to normal gravity.
acknowledgement: This work was supported by a postdoctoral fellowship from the Swedish
  Society for Medical Research to J.R., a CAPES-STINT joint grant to R.G.G. and L.S.W.,
  a PhD fellowship from Karolinska Institutet (KID) to E.D., a PhD fellowship from
  Fundação para a Ciência e a Tecnologia and European Social Fund to M.M.S.O., the
  program of fundamental research (theme 65.1) of the Institute for Biomedical Problems
  of the Russian Academy of Sciences (IBMP RAS) to A.A.S., S.M.S., V.A.S., O.V.K.,
  D.D.V., K.D.O., M.P.R., and S.A.P., the Tamkeen under the NYU Abu Dhabi Research
  Institute Award to the NYUAD Center for Genomics and Systems Biology (ADHPG-CGSB)
  to P.P., the Knut and Alice Wallenberg foundation to C.K., the Swedish National
  Space Agency to N.V.K. and L.S.W., Swedish Research Council, Gösta Fraenckel Foundation,
  and Karolinska Institutet to L.S.W.
article_number: adg1610
article_processing_charge: Yes
article_type: original
author:
- first_name: Carlos J.
  full_name: Gallardo-Dodd, Carlos J.
  last_name: Gallardo-Dodd
- first_name: Christian
  full_name: Oertlin, Christian
  last_name: Oertlin
- first_name: Julien
  full_name: Record, Julien
  last_name: Record
- first_name: Rômulo G.
  full_name: Galvani, Rômulo G.
  last_name: Galvani
- first_name: Christian
  full_name: Sommerauer, Christian
  last_name: Sommerauer
- first_name: Nikolai V.
  full_name: Kuznetsov, Nikolai V.
  last_name: Kuznetsov
- first_name: Evangelos
  full_name: Doukoumopoulos, Evangelos
  last_name: Doukoumopoulos
- first_name: Liaqat
  full_name: Ali, Liaqat
  last_name: Ali
- first_name: Mariana M. S.
  full_name: Oliveira, Mariana M. S.
  last_name: Oliveira
- first_name: Christina
  full_name: Seitz, Christina
  last_name: Seitz
- first_name: Mathias
  full_name: Percipalle, Mathias
  id: 45adb726-eb97-11eb-a6c2-c7c3d3caabe9
  last_name: Percipalle
- first_name: Tijana
  full_name: Nikić, Tijana
  last_name: Nikić
- first_name: Anastasia A.
  full_name: Sadova, Anastasia A.
  last_name: Sadova
- first_name: Sofia M.
  full_name: Shulgina, Sofia M.
  last_name: Shulgina
- first_name: Vjacheslav A.
  full_name: Shmarov, Vjacheslav A.
  last_name: Shmarov
- first_name: Olga V.
  full_name: Kutko, Olga V.
  last_name: Kutko
- first_name: Daria D.
  full_name: Vlasova, Daria D.
  last_name: Vlasova
- first_name: Kseniya D.
  full_name: Orlova, Kseniya D.
  last_name: Orlova
- first_name: Marina P.
  full_name: Rykova, Marina P.
  last_name: Rykova
- first_name: John
  full_name: Andersson, John
  last_name: Andersson
- first_name: Piergiorgio
  full_name: Percipalle, Piergiorgio
  last_name: Percipalle
- first_name: Claudia
  full_name: Kutter, Claudia
  last_name: Kutter
- first_name: Sergey A.
  full_name: Ponomarev, Sergey A.
  last_name: Ponomarev
- first_name: Lisa S.
  full_name: Westerberg, Lisa S.
  last_name: Westerberg
citation:
  ama: Gallardo-Dodd CJ, Oertlin C, Record J, et al. Exposure of volunteers to microgravity
    by dry immersion bed over 21 days results in gene expression changes and adaptation
    of T cells. <i>Science Advances</i>. 2023;9(34). doi:<a href="https://doi.org/10.1126/sciadv.adg1610">10.1126/sciadv.adg1610</a>
  apa: Gallardo-Dodd, C. J., Oertlin, C., Record, J., Galvani, R. G., Sommerauer,
    C., Kuznetsov, N. V., … Westerberg, L. S. (2023). Exposure of volunteers to microgravity
    by dry immersion bed over 21 days results in gene expression changes and adaptation
    of T cells. <i>Science Advances</i>. American Association for the Advancement
    of Science. <a href="https://doi.org/10.1126/sciadv.adg1610">https://doi.org/10.1126/sciadv.adg1610</a>
  chicago: Gallardo-Dodd, Carlos J., Christian Oertlin, Julien Record, Rômulo G. Galvani,
    Christian Sommerauer, Nikolai V. Kuznetsov, Evangelos Doukoumopoulos, et al. “Exposure
    of Volunteers to Microgravity by Dry Immersion Bed over 21 Days Results in Gene
    Expression Changes and Adaptation of T Cells.” <i>Science Advances</i>. American
    Association for the Advancement of Science, 2023. <a href="https://doi.org/10.1126/sciadv.adg1610">https://doi.org/10.1126/sciadv.adg1610</a>.
  ieee: C. J. Gallardo-Dodd <i>et al.</i>, “Exposure of volunteers to microgravity
    by dry immersion bed over 21 days results in gene expression changes and adaptation
    of T cells,” <i>Science Advances</i>, vol. 9, no. 34. American Association for
    the Advancement of Science, 2023.
  ista: Gallardo-Dodd CJ, Oertlin C, Record J, Galvani RG, Sommerauer C, Kuznetsov
    NV, Doukoumopoulos E, Ali L, Oliveira MMS, Seitz C, Percipalle M, Nikić T, Sadova
    AA, Shulgina SM, Shmarov VA, Kutko OV, Vlasova DD, Orlova KD, Rykova MP, Andersson
    J, Percipalle P, Kutter C, Ponomarev SA, Westerberg LS. 2023. Exposure of volunteers
    to microgravity by dry immersion bed over 21 days results in gene expression changes
    and adaptation of T cells. Science Advances. 9(34), adg1610.
  mla: Gallardo-Dodd, Carlos J., et al. “Exposure of Volunteers to Microgravity by
    Dry Immersion Bed over 21 Days Results in Gene Expression Changes and Adaptation
    of T Cells.” <i>Science Advances</i>, vol. 9, no. 34, adg1610, American Association
    for the Advancement of Science, 2023, doi:<a href="https://doi.org/10.1126/sciadv.adg1610">10.1126/sciadv.adg1610</a>.
  short: C.J. Gallardo-Dodd, C. Oertlin, J. Record, R.G. Galvani, C. Sommerauer, N.V.
    Kuznetsov, E. Doukoumopoulos, L. Ali, M.M.S. Oliveira, C. Seitz, M. Percipalle,
    T. Nikić, A.A. Sadova, S.M. Shulgina, V.A. Shmarov, O.V. Kutko, D.D. Vlasova,
    K.D. Orlova, M.P. Rykova, J. Andersson, P. Percipalle, C. Kutter, S.A. Ponomarev,
    L.S. Westerberg, Science Advances 9 (2023).
date_created: 2024-01-10T09:48:01Z
date_published: 2023-08-25T00:00:00Z
date_updated: 2024-01-16T09:38:58Z
day: '25'
ddc:
- '570'
department:
- _id: FlSc
doi: 10.1126/sciadv.adg1610
external_id:
  isi:
  - '001054596800007'
  pmid:
  - '37624890'
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has_accepted_license: '1'
intvolume: '         9'
isi: 1
issue: '34'
keyword:
- Multidisciplinary
language:
- iso: eng
month: '08'
oa: 1
oa_version: Published Version
pmid: 1
publication: Science Advances
publication_identifier:
  issn:
  - 2375-2548
publication_status: published
publisher: American Association for the Advancement of Science
quality_controlled: '1'
status: public
title: Exposure of volunteers to microgravity by dry immersion bed over 21 days results
  in gene expression changes and adaptation of T cells
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
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volume: 9
year: '2023'
...