---
_id: '10135'
abstract:
- lang: eng
  text: "Plants maintain the capacity to develop new organs e.g. lateral roots post-embryonically
    throughout their whole life and thereby flexibly adapt to ever-changing environmental
    conditions. Plant hormones auxin and cytokinin are the main regulators of the
    lateral root organogenesis. Additionally to their solo activities, the interaction
    between auxin and\r\ncytokinin plays crucial role in fine-tuning of lateral root
    development and growth. In particular, cytokinin modulates auxin distribution
    within the developing lateral root by affecting the endomembrane trafficking of
    auxin transporter PIN1 and promoting its vacuolar degradation (Marhavý et al.,
    2011, 2014). This effect is independent of transcription and\r\ntranslation. Therefore,
    it suggests novel, non-canonical cytokinin activity occuring possibly on the posttranslational
    level. Impact of cytokinin and other plant hormones on auxin transporters (including
    PIN1) on the posttranslational level is described in detail in the introduction
    part of this thesis in a form of a review (Semeradova et al., 2020). To gain insights
    into the molecular machinery underlying cytokinin effect on the endomembrane trafficking
    in the plant cell, in particular on the PIN1 degradation, we conducted two large
    proteomic screens: 1) Identification of cytokinin binding proteins using\r\nchemical
    proteomics. 2) Monitoring of proteomic and phosphoproteomic changes upon cytokinin
    treatment. In the first screen, we identified DYNAMIN RELATED PROTEIN 2A (DRP2A).
    We found that DRP2A plays a role in cytokinin regulated processes during the plant
    growth and that cytokinin treatment promotes destabilization of DRP2A protein.
    However, the role of DRP2A in the PIN1 degradation remains to be elucidated. In
    the second screen, we found VACUOLAR PROTEIN SORTING 9A (VPS9A). VPS9a plays crucial
    role in plant’s response to cytokin and in cytokinin mediated PIN1 degradation.
    Altogether, we identified proteins, which bind to cytokinin and proteins that
    in response to\r\ncytokinin exhibit significantly changed abundance or phosphorylation
    pattern. By combining information from these two screens, we can pave our way
    towards understanding of noncanonical cytokinin effects."
alternative_title:
- ISTA Thesis
article_processing_charge: No
author:
- first_name: Hana
  full_name: Semerádová, Hana
  id: 42FE702E-F248-11E8-B48F-1D18A9856A87
  last_name: Semerádová
citation:
  ama: Semerádová H. Molecular mechanisms of the cytokinin-regulated endomembrane
    trafficking to coordinate plant organogenesis. 2021. doi:<a href="https://doi.org/10.15479/at:ista:10135">10.15479/at:ista:10135</a>
  apa: Semerádová, H. (2021). <i>Molecular mechanisms of the cytokinin-regulated endomembrane
    trafficking to coordinate plant organogenesis</i>. Institute of Science and Technology
    Austria. <a href="https://doi.org/10.15479/at:ista:10135">https://doi.org/10.15479/at:ista:10135</a>
  chicago: Semerádová, Hana. “Molecular Mechanisms of the Cytokinin-Regulated Endomembrane
    Trafficking to Coordinate Plant Organogenesis.” Institute of Science and Technology
    Austria, 2021. <a href="https://doi.org/10.15479/at:ista:10135">https://doi.org/10.15479/at:ista:10135</a>.
  ieee: H. Semerádová, “Molecular mechanisms of the cytokinin-regulated endomembrane
    trafficking to coordinate plant organogenesis,” Institute of Science and Technology
    Austria, 2021.
  ista: Semerádová H. 2021. Molecular mechanisms of the cytokinin-regulated endomembrane
    trafficking to coordinate plant organogenesis. Institute of Science and Technology
    Austria.
  mla: Semerádová, Hana. <i>Molecular Mechanisms of the Cytokinin-Regulated Endomembrane
    Trafficking to Coordinate Plant Organogenesis</i>. Institute of Science and Technology
    Austria, 2021, doi:<a href="https://doi.org/10.15479/at:ista:10135">10.15479/at:ista:10135</a>.
  short: H. Semerádová, Molecular Mechanisms of the Cytokinin-Regulated Endomembrane
    Trafficking to Coordinate Plant Organogenesis, Institute of Science and Technology
    Austria, 2021.
date_created: 2021-10-13T13:42:48Z
date_published: 2021-10-13T00:00:00Z
date_updated: 2024-01-25T10:53:29Z
day: '13'
ddc:
- '570'
degree_awarded: PhD
department:
- _id: GradSch
- _id: EvBe
doi: 10.15479/at:ista:10135
file:
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file_date_updated: 2022-12-20T23:30:05Z
has_accepted_license: '1'
language:
- iso: eng
month: '10'
oa: 1
oa_version: Published Version
project:
- _id: 261821BC-B435-11E9-9278-68D0E5697425
  grant_number: '24746'
  name: Molecular mechanisms of the cytokinin regulated endomembrane trafficking to
    coordinate plant organogenesis.
publication_identifier:
  isbn:
  - 978-3-99078-014-5
  issn:
  - 2663-337X
publication_status: published
publisher: Institute of Science and Technology Austria
related_material:
  record:
  - id: '9160'
    relation: part_of_dissertation
    status: public
status: public
supervisor:
- first_name: Eva
  full_name: Benková, Eva
  id: 38F4F166-F248-11E8-B48F-1D18A9856A87
  last_name: Benková
  orcid: 0000-0002-8510-9739
title: Molecular mechanisms of the cytokinin-regulated endomembrane trafficking to
  coordinate plant organogenesis
type: dissertation
user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
year: '2021'
...
---
_id: '7805'
abstract:
- lang: eng
  text: Plants as non-mobile organisms constantly integrate varying environmental
    signals to flexibly adapt their growth and development. Local fluctuations in
    water and nutrient availability, sudden changes in temperature or other abiotic
    and biotic stresses can trigger changes in the growth of plant organs. Multiple
    mutually interconnected hormonal signaling cascades act as essential endogenous
    translators of these exogenous signals in the adaptive responses of plants. Although
    the molecular backbones of hormone transduction pathways have been identified,
    the mechanisms underlying their interactions are largely unknown. Here, using
    genome wide transcriptome profiling we identify an auxin and cytokinin cross-talk
    component; SYNERGISTIC ON AUXIN AND CYTOKININ 1 (SYAC1), whose expression in roots
    is strictly dependent on both of these hormonal pathways. We show that SYAC1 is
    a regulator of secretory pathway, whose enhanced activity interferes with deposition
    of cell wall components and can fine-tune organ growth and sensitivity to soil
    pathogens.
acknowledged_ssus:
- _id: Bio
- _id: LifeSc
acknowledgement: We thank Daria Siekhaus, Jiri Friml and Alexander Johnson for critical
  reading of the manuscript, Peter Pimpl, Christian Luschnig and Liwen Jiang for sharing
  published material, Lesia Rodriguez Solovey for technical assistance. This work
  was supported by the Austrian Science Fund (FWF01_I1774S) to A.H., K.Ö., and E.B.,
  the German Research Foundation (DFG; He3424/6-1 to I.H.), by the People Programme
  (Marie Curie Actions) of the European Union’s Seventh Framework Programme (FP7/2007-2013)
  under REA grant agreement n° [291734] (to N.C.), by the EU in the framework of the
  Marie-Curie FP7 COFUND People Programme through the award of an AgreenSkills+ fellowship
  No. 609398 (to J.S.) and by the Scientific Service Units of IST-Austria through
  resources provided by the Bioimaging Facility, the Life Science Facility. The IJPB
  benefits from the support of Saclay Plant Sciences-SPS (ANR-17-EUR-0007).
article_number: '2170'
article_processing_charge: No
article_type: original
author:
- first_name: Andrej
  full_name: Hurny, Andrej
  id: 4DC4AF46-F248-11E8-B48F-1D18A9856A87
  last_name: Hurny
  orcid: 0000-0003-3638-1426
- first_name: Candela
  full_name: Cuesta, Candela
  id: 33A3C818-F248-11E8-B48F-1D18A9856A87
  last_name: Cuesta
  orcid: 0000-0003-1923-2410
- first_name: Nicola
  full_name: Cavallari, Nicola
  id: 457160E6-F248-11E8-B48F-1D18A9856A87
  last_name: Cavallari
- first_name: Krisztina
  full_name: Ötvös, Krisztina
  id: 29B901B0-F248-11E8-B48F-1D18A9856A87
  last_name: Ötvös
  orcid: 0000-0002-5503-4983
- first_name: Jerome
  full_name: Duclercq, Jerome
  last_name: Duclercq
- first_name: Ladislav
  full_name: Dokládal, Ladislav
  last_name: Dokládal
- first_name: Juan C
  full_name: Montesinos López, Juan C
  id: 310A8E3E-F248-11E8-B48F-1D18A9856A87
  last_name: Montesinos López
  orcid: 0000-0001-9179-6099
- first_name: Marçal
  full_name: Gallemi, Marçal
  id: 460C6802-F248-11E8-B48F-1D18A9856A87
  last_name: Gallemi
  orcid: 0000-0003-4675-6893
- first_name: Hana
  full_name: Semeradova, Hana
  id: 42FE702E-F248-11E8-B48F-1D18A9856A87
  last_name: Semeradova
- first_name: Thomas
  full_name: Rauter, Thomas
  id: A0385D1A-9376-11EA-A47D-9862C5E3AB22
  last_name: Rauter
- first_name: Irene
  full_name: Stenzel, Irene
  last_name: Stenzel
- first_name: Geert
  full_name: Persiau, Geert
  last_name: Persiau
- first_name: Freia
  full_name: Benade, Freia
  last_name: Benade
- first_name: Rishikesh
  full_name: Bhalearo, Rishikesh
  last_name: Bhalearo
- first_name: Eva
  full_name: Sýkorová, Eva
  last_name: Sýkorová
- first_name: András
  full_name: Gorzsás, András
  last_name: Gorzsás
- first_name: Julien
  full_name: Sechet, Julien
  last_name: Sechet
- first_name: Gregory
  full_name: Mouille, Gregory
  last_name: Mouille
- first_name: Ingo
  full_name: Heilmann, Ingo
  last_name: Heilmann
- first_name: Geert
  full_name: De Jaeger, Geert
  last_name: De Jaeger
- first_name: Jutta
  full_name: Ludwig-Müller, Jutta
  last_name: Ludwig-Müller
- first_name: Eva
  full_name: Benková, Eva
  id: 38F4F166-F248-11E8-B48F-1D18A9856A87
  last_name: Benková
  orcid: 0000-0002-8510-9739
citation:
  ama: Hurny A, Cuesta C, Cavallari N, et al. Synergistic on Auxin and Cytokinin 1
    positively regulates growth and attenuates soil pathogen resistance. <i>Nature
    Communications</i>. 2020;11. doi:<a href="https://doi.org/10.1038/s41467-020-15895-5">10.1038/s41467-020-15895-5</a>
  apa: Hurny, A., Cuesta, C., Cavallari, N., Ötvös, K., Duclercq, J., Dokládal, L.,
    … Benková, E. (2020). Synergistic on Auxin and Cytokinin 1 positively regulates
    growth and attenuates soil pathogen resistance. <i>Nature Communications</i>.
    Springer Nature. <a href="https://doi.org/10.1038/s41467-020-15895-5">https://doi.org/10.1038/s41467-020-15895-5</a>
  chicago: Hurny, Andrej, Candela Cuesta, Nicola Cavallari, Krisztina Ötvös, Jerome
    Duclercq, Ladislav Dokládal, Juan C Montesinos López, et al. “Synergistic on Auxin
    and Cytokinin 1 Positively Regulates Growth and Attenuates Soil Pathogen Resistance.”
    <i>Nature Communications</i>. Springer Nature, 2020. <a href="https://doi.org/10.1038/s41467-020-15895-5">https://doi.org/10.1038/s41467-020-15895-5</a>.
  ieee: A. Hurny <i>et al.</i>, “Synergistic on Auxin and Cytokinin 1 positively regulates
    growth and attenuates soil pathogen resistance,” <i>Nature Communications</i>,
    vol. 11. Springer Nature, 2020.
  ista: Hurny A, Cuesta C, Cavallari N, Ötvös K, Duclercq J, Dokládal L, Montesinos
    López JC, Gallemi M, Semerádová H, Rauter T, Stenzel I, Persiau G, Benade F, Bhalearo
    R, Sýkorová E, Gorzsás A, Sechet J, Mouille G, Heilmann I, De Jaeger G, Ludwig-Müller
    J, Benková E. 2020. Synergistic on Auxin and Cytokinin 1 positively regulates
    growth and attenuates soil pathogen resistance. Nature Communications. 11, 2170.
  mla: Hurny, Andrej, et al. “Synergistic on Auxin and Cytokinin 1 Positively Regulates
    Growth and Attenuates Soil Pathogen Resistance.” <i>Nature Communications</i>,
    vol. 11, 2170, Springer Nature, 2020, doi:<a href="https://doi.org/10.1038/s41467-020-15895-5">10.1038/s41467-020-15895-5</a>.
  short: A. Hurny, C. Cuesta, N. Cavallari, K. Ötvös, J. Duclercq, L. Dokládal, J.C.
    Montesinos López, M. Gallemi, H. Semerádová, T. Rauter, I. Stenzel, G. Persiau,
    F. Benade, R. Bhalearo, E. Sýkorová, A. Gorzsás, J. Sechet, G. Mouille, I. Heilmann,
    G. De Jaeger, J. Ludwig-Müller, E. Benková, Nature Communications 11 (2020).
date_created: 2020-05-10T22:00:48Z
date_published: 2020-05-01T00:00:00Z
date_updated: 2023-08-21T06:21:56Z
day: '01'
ddc:
- '570'
department:
- _id: EvBe
doi: 10.1038/s41467-020-15895-5
ec_funded: 1
external_id:
  isi:
  - '000531425900012'
  pmid:
  - '32358503'
file:
- access_level: open_access
  checksum: 2cba327c9e9416d75cb96be54b0fb441
  content_type: application/pdf
  creator: dernst
  date_created: 2020-10-06T07:47:53Z
  date_updated: 2020-10-06T07:47:53Z
  file_id: '8614'
  file_name: 2020_NatureComm_Hurny.pdf
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  success: 1
file_date_updated: 2020-10-06T07:47:53Z
has_accepted_license: '1'
intvolume: '        11'
isi: 1
language:
- iso: eng
month: '05'
oa: 1
oa_version: Published Version
pmid: 1
project:
- _id: 2542D156-B435-11E9-9278-68D0E5697425
  call_identifier: FWF
  grant_number: I 1774-B16
  name: Hormone cross-talk drives nutrient dependent plant development
- _id: 25681D80-B435-11E9-9278-68D0E5697425
  call_identifier: FP7
  grant_number: '291734'
  name: International IST Postdoc Fellowship Programme
publication: Nature Communications
publication_identifier:
  eissn:
  - '20411723'
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: Synergistic on Auxin and Cytokinin 1 positively regulates growth and attenuates
  soil pathogen resistance
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 11
year: '2020'
...
---
_id: '8336'
abstract:
- lang: eng
  text: Plant hormone cytokinins are perceived by a subfamily of sensor histidine
    kinases (HKs), which via a two-component phosphorelay cascade activate transcriptional
    responses in the nucleus. Subcellular localization of the receptors proposed the
    endoplasmic reticulum (ER) membrane as a principal cytokinin perception site,
    while study of cytokinin transport pointed to the plasma membrane (PM)-mediated
    cytokinin signalling. Here, by detailed monitoring of subcellular localizations
    of the fluorescently labelled natural cytokinin probe and the receptor ARABIDOPSIS
    HISTIDINE KINASE 4 (CRE1/AHK4) fused to GFP reporter, we show that pools of the
    ER-located cytokinin receptors can enter the secretory pathway and reach the PM
    in cells of the root apical meristem, and the cell plate of dividing meristematic
    cells. Brefeldin A (BFA) experiments revealed vesicular recycling of the receptor
    and its accumulation in BFA compartments. We provide a revised view on cytokinin
    signalling and the possibility of multiple sites of perception at PM and ER.
acknowledged_ssus:
- _id: Bio
- _id: LifeSc
acknowledgement: This paper is dedicated to deceased P. Galuszka for his support and
  contribution to the project. This research was supported by the Scientific Service
  Units (SSU) of IST-Austria through resources provided by the Bioimaging Facility
  (BIF), the Life Science Facility (LSF) and by Centre of the Region Haná (CRH), Palacký
  University. We thank Lucia Hlusková, Zuzana Pěkná and Martin Hönig for technical
  assistance, and Fernando Aniento, Rashed Abualia and Andrej Hurný for sharing material.
  The work was supported from ERDF project “Plants as a tool for sustainable global
  development” (No. CZ.02.1.01/0.0/0.0/16_019/0000827), from Czech Science Foundation
  via projects 16-04184S (O.P., K.K. and K.D.), 18-23972Y (D.Z., K.K.), 17-21122S
  (K.B.), Erasmus+ (K.K.), Endowment Fund of Palacký University (K.K.) and EMBO Long-Term
  Fellowship, ALTF number 710-2016 (J.C.M.); People Programme (Marie Curie Actions)
  of the European Union’s Seventh Framework Programme (FP7/2007-2013) under REA grant
  agreement no. [291734] (N.C.); DOC Fellowship of the Austrian Academy of Sciences
  at the Institute of Science and Technology, Austria (H.S.).
article_number: '4285'
article_processing_charge: No
article_type: original
author:
- first_name: Karolina
  full_name: Kubiasova, Karolina
  id: 946011F4-3E71-11EA-860B-C7A73DDC885E
  last_name: Kubiasova
  orcid: 0000-0001-5630-9419
- first_name: Juan C
  full_name: Montesinos López, Juan C
  id: 310A8E3E-F248-11E8-B48F-1D18A9856A87
  last_name: Montesinos López
  orcid: 0000-0001-9179-6099
- first_name: Olga
  full_name: Šamajová, Olga
  last_name: Šamajová
- first_name: Jaroslav
  full_name: Nisler, Jaroslav
  last_name: Nisler
- first_name: Václav
  full_name: Mik, Václav
  last_name: Mik
- first_name: Hana
  full_name: Semeradova, Hana
  id: 42FE702E-F248-11E8-B48F-1D18A9856A87
  last_name: Semeradova
- first_name: Lucie
  full_name: Plíhalová, Lucie
  last_name: Plíhalová
- first_name: Ondřej
  full_name: Novák, Ondřej
  last_name: Novák
- first_name: Peter
  full_name: Marhavý, Peter
  id: 3F45B078-F248-11E8-B48F-1D18A9856A87
  last_name: Marhavý
  orcid: 0000-0001-5227-5741
- first_name: Nicola
  full_name: Cavallari, Nicola
  id: 457160E6-F248-11E8-B48F-1D18A9856A87
  last_name: Cavallari
- first_name: David
  full_name: Zalabák, David
  last_name: Zalabák
- first_name: Karel
  full_name: Berka, Karel
  last_name: Berka
- first_name: Karel
  full_name: Doležal, Karel
  last_name: Doležal
- first_name: Petr
  full_name: Galuszka, Petr
  last_name: Galuszka
- first_name: Jozef
  full_name: Šamaj, Jozef
  last_name: Šamaj
- first_name: Miroslav
  full_name: Strnad, Miroslav
  last_name: Strnad
- first_name: Eva
  full_name: Benková, Eva
  id: 38F4F166-F248-11E8-B48F-1D18A9856A87
  last_name: Benková
  orcid: 0000-0002-8510-9739
- first_name: Ondřej
  full_name: Plíhal, Ondřej
  last_name: Plíhal
- first_name: Lukáš
  full_name: Spíchal, Lukáš
  last_name: Spíchal
citation:
  ama: Kubiasova K, Montesinos López JC, Šamajová O, et al. Cytokinin fluoroprobe
    reveals multiple sites of cytokinin perception at plasma membrane and endoplasmic
    reticulum. <i>Nature Communications</i>. 2020;11. doi:<a href="https://doi.org/10.1038/s41467-020-17949-0">10.1038/s41467-020-17949-0</a>
  apa: Kubiasova, K., Montesinos López, J. C., Šamajová, O., Nisler, J., Mik, V.,
    Semerádová, H., … Spíchal, L. (2020). Cytokinin fluoroprobe reveals multiple sites
    of cytokinin perception at plasma membrane and endoplasmic reticulum. <i>Nature
    Communications</i>. Springer Nature. <a href="https://doi.org/10.1038/s41467-020-17949-0">https://doi.org/10.1038/s41467-020-17949-0</a>
  chicago: Kubiasova, Karolina, Juan C Montesinos López, Olga Šamajová, Jaroslav Nisler,
    Václav Mik, Hana Semerádová, Lucie Plíhalová, et al. “Cytokinin Fluoroprobe Reveals
    Multiple Sites of Cytokinin Perception at Plasma Membrane and Endoplasmic Reticulum.”
    <i>Nature Communications</i>. Springer Nature, 2020. <a href="https://doi.org/10.1038/s41467-020-17949-0">https://doi.org/10.1038/s41467-020-17949-0</a>.
  ieee: K. Kubiasova <i>et al.</i>, “Cytokinin fluoroprobe reveals multiple sites
    of cytokinin perception at plasma membrane and endoplasmic reticulum,” <i>Nature
    Communications</i>, vol. 11. Springer Nature, 2020.
  ista: Kubiasova K, Montesinos López JC, Šamajová O, Nisler J, Mik V, Semerádová
    H, Plíhalová L, Novák O, Marhavý P, Cavallari N, Zalabák D, Berka K, Doležal K,
    Galuszka P, Šamaj J, Strnad M, Benková E, Plíhal O, Spíchal L. 2020. Cytokinin
    fluoroprobe reveals multiple sites of cytokinin perception at plasma membrane
    and endoplasmic reticulum. Nature Communications. 11, 4285.
  mla: Kubiasova, Karolina, et al. “Cytokinin Fluoroprobe Reveals Multiple Sites of
    Cytokinin Perception at Plasma Membrane and Endoplasmic Reticulum.” <i>Nature
    Communications</i>, vol. 11, 4285, Springer Nature, 2020, doi:<a href="https://doi.org/10.1038/s41467-020-17949-0">10.1038/s41467-020-17949-0</a>.
  short: K. Kubiasova, J.C. Montesinos López, O. Šamajová, J. Nisler, V. Mik, H. Semerádová,
    L. Plíhalová, O. Novák, P. Marhavý, N. Cavallari, D. Zalabák, K. Berka, K. Doležal,
    P. Galuszka, J. Šamaj, M. Strnad, E. Benková, O. Plíhal, L. Spíchal, Nature Communications
    11 (2020).
date_created: 2020-09-06T22:01:12Z
date_published: 2020-08-27T00:00:00Z
date_updated: 2023-08-22T09:09:06Z
day: '27'
ddc:
- '580'
department:
- _id: EvBe
doi: 10.1038/s41467-020-17949-0
ec_funded: 1
external_id:
  isi:
  - '000567931000002'
  pmid:
  - '32855390'
file:
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  checksum: 7494b7665b3d2bf2d8edb13e4f12b92d
  content_type: application/pdf
  creator: dernst
  date_created: 2020-09-10T08:05:19Z
  date_updated: 2020-09-10T08:05:19Z
  file_id: '8357'
  file_name: 2020_NatureComm_Kubiasova.pdf
  file_size: 3455704
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  call_identifier: FP7
  grant_number: '291734'
  name: International IST Postdoc Fellowship Programme
- _id: 261821BC-B435-11E9-9278-68D0E5697425
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  name: Molecular mechanisms of the cytokinin regulated endomembrane trafficking to
    coordinate plant organogenesis.
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  grant_number: ALTF710-2016
  name: Molecular mechanism of auxindriven formative divisions delineating lateral
    root organogenesis in plants
publication: Nature Communications
publication_identifier:
  eissn:
  - '20411723'
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: Cytokinin fluoroprobe reveals multiple sites of cytokinin perception at plasma
  membrane and endoplasmic reticulum
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type: journal_article
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---
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abstract:
- lang: eng
  text: Auxin is a key hormonal regulator, that governs plant growth and development
    in concert with other hormonal pathways. The unique feature of auxin is its polar,
    cell-to-cell transport that leads to the formation of local auxin maxima and gradients,
    which coordinate initiation and patterning of plant organs. The molecular machinery
    mediating polar auxin transport is one of the important points of interaction
    with other hormones. Multiple hormonal pathways converge at the regulation of
    auxin transport and form a regulatory network that integrates various developmental
    and environmental inputs to steer plant development. In this review, we discuss
    recent advances in understanding the mechanisms that underlie regulation of polar
    auxin transport by multiple hormonal pathways. Specifically, we focus on the post-translational
    mechanisms that contribute to fine-tuning of the abundance and polarity of auxin
    transporters at the plasma membrane and thereby enable rapid modification of the
    auxin flow to coordinate plant growth and development.
acknowledgement: H.S. is the recipient of a DOC Fellowship of the Austrian Academy
  of Sciences at the Institute of Science and Technology, Austria. J.C.M. is the recipient
  of an EMBO Long-Term Fellowship (ALTF number 710-2016). We would like to thank Jiri
  Friml and Carina Baskett for critical reading of the manuscript and Shutang Tan
  and Maciek Adamowski for helpful discussions. No conflict of interest declared.
article_number: '100048'
article_processing_charge: No
article_type: original
author:
- first_name: Hana
  full_name: Semeradova, Hana
  id: 42FE702E-F248-11E8-B48F-1D18A9856A87
  last_name: Semeradova
- first_name: Juan C
  full_name: Montesinos López, Juan C
  id: 310A8E3E-F248-11E8-B48F-1D18A9856A87
  last_name: Montesinos López
  orcid: 0000-0001-9179-6099
- first_name: Eva
  full_name: Benková, Eva
  id: 38F4F166-F248-11E8-B48F-1D18A9856A87
  last_name: Benková
  orcid: 0000-0002-8510-9739
citation:
  ama: 'Semerádová H, Montesinos López JC, Benková E. All roads lead to auxin: Post-translational
    regulation of auxin transport by multiple hormonal pathways. <i>Plant Communications</i>.
    2020;1(3). doi:<a href="https://doi.org/10.1016/j.xplc.2020.100048">10.1016/j.xplc.2020.100048</a>'
  apa: 'Semerádová, H., Montesinos López, J. C., &#38; Benková, E. (2020). All roads
    lead to auxin: Post-translational regulation of auxin transport by multiple hormonal
    pathways. <i>Plant Communications</i>. Elsevier. <a href="https://doi.org/10.1016/j.xplc.2020.100048">https://doi.org/10.1016/j.xplc.2020.100048</a>'
  chicago: 'Semerádová, Hana, Juan C Montesinos López, and Eva Benková. “All Roads
    Lead to Auxin: Post-Translational Regulation of Auxin Transport by Multiple Hormonal
    Pathways.” <i>Plant Communications</i>. Elsevier, 2020. <a href="https://doi.org/10.1016/j.xplc.2020.100048">https://doi.org/10.1016/j.xplc.2020.100048</a>.'
  ieee: 'H. Semerádová, J. C. Montesinos López, and E. Benková, “All roads lead to
    auxin: Post-translational regulation of auxin transport by multiple hormonal pathways,”
    <i>Plant Communications</i>, vol. 1, no. 3. Elsevier, 2020.'
  ista: 'Semerádová H, Montesinos López JC, Benková E. 2020. All roads lead to auxin:
    Post-translational regulation of auxin transport by multiple hormonal pathways.
    Plant Communications. 1(3), 100048.'
  mla: 'Semerádová, Hana, et al. “All Roads Lead to Auxin: Post-Translational Regulation
    of Auxin Transport by Multiple Hormonal Pathways.” <i>Plant Communications</i>,
    vol. 1, no. 3, 100048, Elsevier, 2020, doi:<a href="https://doi.org/10.1016/j.xplc.2020.100048">10.1016/j.xplc.2020.100048</a>.'
  short: H. Semerádová, J.C. Montesinos López, E. Benková, Plant Communications 1
    (2020).
date_created: 2021-02-18T10:18:43Z
date_published: 2020-05-11T00:00:00Z
date_updated: 2024-03-25T23:30:26Z
day: '11'
ddc:
- '580'
department:
- _id: EvBe
doi: 10.1016/j.xplc.2020.100048
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  grant_number: '24746'
  name: Molecular mechanisms of the cytokinin regulated endomembrane trafficking to
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- _id: 253E54C8-B435-11E9-9278-68D0E5697425
  grant_number: ALTF710-2016
  name: Molecular mechanism of auxindriven formative divisions delineating lateral
    root organogenesis in plants
publication: Plant Communications
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  issn:
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publication_status: published
publisher: Elsevier
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title: 'All roads lead to auxin: Post-translational regulation of auxin transport
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