---
_id: '678'
abstract:
- lang: eng
  text: The seminal observation that mechanical signals can elicit changes in biochemical
    signalling within cells, a process commonly termed mechanosensation and mechanotransduction,
    has revolutionized our understanding of the role of cell mechanics in various
    fundamental biological processes, such as cell motility, adhesion, proliferation
    and differentiation. In this Review, we will discuss how the interplay and feedback
    between mechanical and biochemical signals control tissue morphogenesis and cell
    fate specification in embryonic development.
author:
- first_name: Nicoletta
  full_name: Petridou, Nicoletta
  id: 2A003F6C-F248-11E8-B48F-1D18A9856A87
  last_name: Petridou
  orcid: 0000-0002-8451-1195
- first_name: Zoltan P
  full_name: Spiro, Zoltan P
  id: 426AD026-F248-11E8-B48F-1D18A9856A87
  last_name: Spiro
- first_name: Carl-Philipp J
  full_name: Heisenberg, Carl-Philipp J
  id: 39427864-F248-11E8-B48F-1D18A9856A87
  last_name: Heisenberg
  orcid: 0000-0002-0912-4566
citation:
  ama: Petridou N, Spiro ZP, Heisenberg C-PJ. Multiscale force sensing in development.
    <i>Nature Cell Biology</i>. 2017;19(6):581-588. doi:<a href="https://doi.org/10.1038/ncb3524">10.1038/ncb3524</a>
  apa: Petridou, N., Spiro, Z. P., &#38; Heisenberg, C.-P. J. (2017). Multiscale force
    sensing in development. <i>Nature Cell Biology</i>. Nature Publishing Group. <a
    href="https://doi.org/10.1038/ncb3524">https://doi.org/10.1038/ncb3524</a>
  chicago: Petridou, Nicoletta, Zoltan P Spiro, and Carl-Philipp J Heisenberg. “Multiscale
    Force Sensing in Development.” <i>Nature Cell Biology</i>. Nature Publishing Group,
    2017. <a href="https://doi.org/10.1038/ncb3524">https://doi.org/10.1038/ncb3524</a>.
  ieee: N. Petridou, Z. P. Spiro, and C.-P. J. Heisenberg, “Multiscale force sensing
    in development,” <i>Nature Cell Biology</i>, vol. 19, no. 6. Nature Publishing
    Group, pp. 581–588, 2017.
  ista: Petridou N, Spiro ZP, Heisenberg C-PJ. 2017. Multiscale force sensing in development.
    Nature Cell Biology. 19(6), 581–588.
  mla: Petridou, Nicoletta, et al. “Multiscale Force Sensing in Development.” <i>Nature
    Cell Biology</i>, vol. 19, no. 6, Nature Publishing Group, 2017, pp. 581–88, doi:<a
    href="https://doi.org/10.1038/ncb3524">10.1038/ncb3524</a>.
  short: N. Petridou, Z.P. Spiro, C.-P.J. Heisenberg, Nature Cell Biology 19 (2017)
    581–588.
date_created: 2018-12-11T11:47:53Z
date_published: 2017-05-31T00:00:00Z
date_updated: 2021-01-12T08:08:59Z
day: '31'
department:
- _id: CaHe
doi: 10.1038/ncb3524
intvolume: '        19'
issue: '6'
language:
- iso: eng
month: '05'
oa_version: None
page: 581 - 588
project:
- _id: 25236028-B435-11E9-9278-68D0E5697425
  grant_number: ALTF534-2016
  name: The generation and function of anisotropic tissue tension in zebrafish epiboly
    (EMBO Fellowship)
publication: Nature Cell Biology
publication_identifier:
  issn:
  - '14657392'
publication_status: published
publisher: Nature Publishing Group
publist_id: '7040'
quality_controlled: '1'
scopus_import: 1
status: public
title: Multiscale force sensing in development
type: journal_article
user_id: 4435EBFC-F248-11E8-B48F-1D18A9856A87
volume: 19
year: '2017'
...
---
_id: '729'
abstract:
- lang: eng
  text: The cellular mechanisms allowing tissues to efficiently regenerate are not
    fully understood. In this issue of Developmental Cell, Cao et al. (2017)) discover
    that during zebrafish heart regeneration, epicardial cells at the leading edge
    of regenerating tissue undergo endoreplication, possibly due to increased tissue
    tension, thereby boosting their regenerative capacity.
article_processing_charge: No
author:
- first_name: Zoltan P
  full_name: Spiro, Zoltan P
  id: 426AD026-F248-11E8-B48F-1D18A9856A87
  last_name: Spiro
- first_name: Carl-Philipp J
  full_name: Heisenberg, Carl-Philipp J
  id: 39427864-F248-11E8-B48F-1D18A9856A87
  last_name: Heisenberg
  orcid: 0000-0002-0912-4566
citation:
  ama: Spiro ZP, Heisenberg C-PJ. Regeneration tensed up polyploidy takes the lead.
    <i>Developmental Cell</i>. 2017;42(6):559-560. doi:<a href="https://doi.org/10.1016/j.devcel.2017.09.008">10.1016/j.devcel.2017.09.008</a>
  apa: Spiro, Z. P., &#38; Heisenberg, C.-P. J. (2017). Regeneration tensed up polyploidy
    takes the lead. <i>Developmental Cell</i>. Cell Press. <a href="https://doi.org/10.1016/j.devcel.2017.09.008">https://doi.org/10.1016/j.devcel.2017.09.008</a>
  chicago: Spiro, Zoltan P, and Carl-Philipp J Heisenberg. “Regeneration Tensed up
    Polyploidy Takes the Lead.” <i>Developmental Cell</i>. Cell Press, 2017. <a href="https://doi.org/10.1016/j.devcel.2017.09.008">https://doi.org/10.1016/j.devcel.2017.09.008</a>.
  ieee: Z. P. Spiro and C.-P. J. Heisenberg, “Regeneration tensed up polyploidy takes
    the lead,” <i>Developmental Cell</i>, vol. 42, no. 6. Cell Press, pp. 559–560,
    2017.
  ista: Spiro ZP, Heisenberg C-PJ. 2017. Regeneration tensed up polyploidy takes the
    lead. Developmental Cell. 42(6), 559–560.
  mla: Spiro, Zoltan P., and Carl-Philipp J. Heisenberg. “Regeneration Tensed up Polyploidy
    Takes the Lead.” <i>Developmental Cell</i>, vol. 42, no. 6, Cell Press, 2017,
    pp. 559–60, doi:<a href="https://doi.org/10.1016/j.devcel.2017.09.008">10.1016/j.devcel.2017.09.008</a>.
  short: Z.P. Spiro, C.-P.J. Heisenberg, Developmental Cell 42 (2017) 559–560.
date_created: 2018-12-11T11:48:11Z
date_published: 2017-01-01T00:00:00Z
date_updated: 2023-09-28T11:32:49Z
day: '01'
department:
- _id: CaHe
doi: 10.1016/j.devcel.2017.09.008
external_id:
  isi:
  - '000411582800003'
intvolume: '        42'
isi: 1
issue: '6'
language:
- iso: eng
month: '01'
oa_version: None
page: 559 - 560
publication: Developmental Cell
publication_identifier:
  issn:
  - '15345807'
publication_status: published
publisher: Cell Press
publist_id: '6948'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Regeneration tensed up polyploidy takes the lead
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 42
year: '2017'
...