---
_id: '8740'
abstract:
- lang: eng
text: In vitro work revealed that excitatory synaptic inputs to hippocampal inhibitory
interneurons could undergo Hebbian, associative, or non-associative plasticity.
Both behavioral and learning-dependent reorganization of these connections has
also been demonstrated by measuring spike transmission probabilities in pyramidal
cell-interneuron spike cross-correlations that indicate monosynaptic connections.
Here we investigated the activity-dependent modification of these connections
during exploratory behavior in rats by optogenetically inhibiting pyramidal cell
and interneuron subpopulations. Light application and associated firing alteration
of pyramidal and interneuron populations led to lasting changes in pyramidal-interneuron
connection weights as indicated by spike transmission changes. Spike transmission
alterations were predicted by the light-mediated changes in the number of pre-
and postsynaptic spike pairing events and by firing rate changes of interneurons
but not pyramidal cells. This work demonstrates the presence of activity-dependent
associative and non-associative reorganization of pyramidal-interneuron connections
triggered by the optogenetic modification of the firing rate and spike synchrony
of cells.
acknowledgement: We thank Michele Nardin and Federico Stella for comments on an earlier
version of the manuscript. K Deisseroth for providing the pAAV-CaMKIIα::eNpHR3.0-YFP
plasmid through Addgene. E Boyden for providing AAV2/1.CaMKII::ArchT.GFP.WPRE.SV40
plasmid through Penn Vector Core. This work was supported by the Austrian Science
Fund (I02072 and I03713) and a Swiss National Science Foundation grant to PS. The
authors declare no conflicts of interest.
article_number: '61106'
article_processing_charge: No
article_type: original
author:
- first_name: Igor
full_name: Gridchyn, Igor
id: 4B60654C-F248-11E8-B48F-1D18A9856A87
last_name: Gridchyn
orcid: 0000-0002-1807-1929
- first_name: Philipp
full_name: Schönenberger, Philipp
id: 3B9D816C-F248-11E8-B48F-1D18A9856A87
last_name: Schönenberger
- first_name: Joseph
full_name: O'Neill, Joseph
id: 426376DC-F248-11E8-B48F-1D18A9856A87
last_name: O'Neill
- first_name: Jozsef L
full_name: Csicsvari, Jozsef L
id: 3FA14672-F248-11E8-B48F-1D18A9856A87
last_name: Csicsvari
orcid: 0000-0002-5193-4036
citation:
ama: Gridchyn I, Schönenberger P, O’Neill J, Csicsvari JL. Optogenetic inhibition-mediated
activity-dependent modification of CA1 pyramidal-interneuron connections during
behavior. eLife. 2020;9. doi:10.7554/eLife.61106
apa: Gridchyn, I., Schönenberger, P., O’Neill, J., & Csicsvari, J. L. (2020).
Optogenetic inhibition-mediated activity-dependent modification of CA1 pyramidal-interneuron
connections during behavior. ELife. eLife Sciences Publications. https://doi.org/10.7554/eLife.61106
chicago: Gridchyn, Igor, Philipp Schönenberger, Joseph O’Neill, and Jozsef L Csicsvari.
“Optogenetic Inhibition-Mediated Activity-Dependent Modification of CA1 Pyramidal-Interneuron
Connections during Behavior.” ELife. eLife Sciences Publications, 2020.
https://doi.org/10.7554/eLife.61106.
ieee: I. Gridchyn, P. Schönenberger, J. O’Neill, and J. L. Csicsvari, “Optogenetic
inhibition-mediated activity-dependent modification of CA1 pyramidal-interneuron
connections during behavior,” eLife, vol. 9. eLife Sciences Publications,
2020.
ista: Gridchyn I, Schönenberger P, O’Neill J, Csicsvari JL. 2020. Optogenetic inhibition-mediated
activity-dependent modification of CA1 pyramidal-interneuron connections during
behavior. eLife. 9, 61106.
mla: Gridchyn, Igor, et al. “Optogenetic Inhibition-Mediated Activity-Dependent
Modification of CA1 Pyramidal-Interneuron Connections during Behavior.” ELife,
vol. 9, 61106, eLife Sciences Publications, 2020, doi:10.7554/eLife.61106.
short: I. Gridchyn, P. Schönenberger, J. O’Neill, J.L. Csicsvari, ELife 9 (2020).
date_created: 2020-11-08T23:01:25Z
date_published: 2020-10-05T00:00:00Z
date_updated: 2024-02-21T12:43:40Z
day: '05'
ddc:
- '570'
department:
- _id: JoCs
doi: 10.7554/eLife.61106
external_id:
isi:
- '000584369000001'
file:
- access_level: open_access
checksum: 6a7b0543c440f4c000a1864e69377d95
content_type: application/pdf
creator: dernst
date_created: 2020-11-09T09:17:40Z
date_updated: 2020-11-09T09:17:40Z
file_id: '8749'
file_name: 2020_eLife_Gridchyn.pdf
file_size: 447669
relation: main_file
success: 1
file_date_updated: 2020-11-09T09:17:40Z
has_accepted_license: '1'
intvolume: ' 9'
isi: 1
language:
- iso: eng
month: '10'
oa: 1
oa_version: Published Version
project:
- _id: 257D4372-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: I2072-B27
name: Interneuron plasticity during spatial learning
- _id: 2654F984-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: I03713
name: Interneuro Plasticity During Spatial Learning
publication: eLife
publication_identifier:
eissn:
- 2050084X
publication_status: published
publisher: eLife Sciences Publications
quality_controlled: '1'
related_material:
record:
- id: '8563'
relation: research_data
status: public
scopus_import: '1'
status: public
title: Optogenetic inhibition-mediated activity-dependent modification of CA1 pyramidal-interneuron
connections during behavior
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 9
year: '2020'
...
---
_id: '7684'
article_processing_charge: No
article_type: original
author:
- first_name: Igor
full_name: Gridchyn, Igor
id: 4B60654C-F248-11E8-B48F-1D18A9856A87
last_name: Gridchyn
orcid: 0000-0002-1807-1929
- first_name: Philipp
full_name: Schönenberger, Philipp
id: 3B9D816C-F248-11E8-B48F-1D18A9856A87
last_name: Schönenberger
- first_name: Joseph
full_name: O'Neill, Joseph
id: 426376DC-F248-11E8-B48F-1D18A9856A87
last_name: O'Neill
- first_name: Jozsef L
full_name: Csicsvari, Jozsef L
id: 3FA14672-F248-11E8-B48F-1D18A9856A87
last_name: Csicsvari
orcid: 0000-0002-5193-4036
citation:
ama: Gridchyn I, Schönenberger P, O’Neill J, Csicsvari JL. Assembly-specific disruption
of hippocampal replay leads to selective memory deficit. Neuron. 2020;106(2):291-300.e6.
doi:10.1016/j.neuron.2020.01.021
apa: Gridchyn, I., Schönenberger, P., O’Neill, J., & Csicsvari, J. L. (2020).
Assembly-specific disruption of hippocampal replay leads to selective memory deficit.
Neuron. Elsevier. https://doi.org/10.1016/j.neuron.2020.01.021
chicago: Gridchyn, Igor, Philipp Schönenberger, Joseph O’Neill, and Jozsef L Csicsvari.
“Assembly-Specific Disruption of Hippocampal Replay Leads to Selective Memory
Deficit.” Neuron. Elsevier, 2020. https://doi.org/10.1016/j.neuron.2020.01.021.
ieee: I. Gridchyn, P. Schönenberger, J. O’Neill, and J. L. Csicsvari, “Assembly-specific
disruption of hippocampal replay leads to selective memory deficit,” Neuron,
vol. 106, no. 2. Elsevier, p. 291–300.e6, 2020.
ista: Gridchyn I, Schönenberger P, O’Neill J, Csicsvari JL. 2020. Assembly-specific
disruption of hippocampal replay leads to selective memory deficit. Neuron. 106(2),
291–300.e6.
mla: Gridchyn, Igor, et al. “Assembly-Specific Disruption of Hippocampal Replay
Leads to Selective Memory Deficit.” Neuron, vol. 106, no. 2, Elsevier,
2020, p. 291–300.e6, doi:10.1016/j.neuron.2020.01.021.
short: I. Gridchyn, P. Schönenberger, J. O’Neill, J.L. Csicsvari, Neuron 106 (2020)
291–300.e6.
date_created: 2020-04-26T22:00:45Z
date_published: 2020-04-22T00:00:00Z
date_updated: 2023-08-21T06:15:31Z
day: '22'
department:
- _id: JoCs
doi: 10.1016/j.neuron.2020.01.021
ec_funded: 1
external_id:
isi:
- '000528268200013'
pmid:
- '32070475'
intvolume: ' 106'
isi: 1
issue: '2'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1016/j.neuron.2020.01.021
month: '04'
oa: 1
oa_version: Published Version
page: 291-300.e6
pmid: 1
project:
- _id: 257A4776-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '281511'
name: Memory-related information processing in neuronal circuits of the hippocampus
and entorhinal cortex
publication: Neuron
publication_identifier:
eissn:
- '10974199'
issn:
- '08966273'
publication_status: published
publisher: Elsevier
quality_controlled: '1'
related_material:
link:
- description: News on IST Homepage
relation: press_release
url: https://ist.ac.at/en/news/librarian-of-memory/
scopus_import: '1'
status: public
title: Assembly-specific disruption of hippocampal replay leads to selective memory
deficit
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 106
year: '2020'
...
---
_id: '5828'
abstract:
- lang: eng
text: Hippocampus is needed for both spatial working and reference memories. Here,
using a radial eight-arm maze, we examined how the combined demand on these memories
influenced CA1 place cell assemblies while reference memories were partially updated.
This was contrasted with control tasks requiring only working memory or the update
of reference memory. Reference memory update led to the reward-directed place
field shifts at newly rewarded arms and to the gradual strengthening of firing
in passes between newly rewarded arms but not between those passes that included
a familiar-rewarded arm. At the maze center, transient network synchronization
periods preferentially replayed trajectories of the next chosen arm in reference
memory tasks but the previously visited arm in the working memory task. Hence,
reference memory demand was uniquely associated with a gradual, goal novelty-related
reorganization of place cell assemblies and with trajectory replay that reflected
the animal's decision of which arm to visit next.
article_processing_charge: No
article_type: original
author:
- first_name: Haibing
full_name: Xu, Haibing
id: 310349D0-F248-11E8-B48F-1D18A9856A87
last_name: Xu
- first_name: Peter
full_name: Baracskay, Peter
id: 361CC00E-F248-11E8-B48F-1D18A9856A87
last_name: Baracskay
- first_name: Joseph
full_name: O'Neill, Joseph
id: 426376DC-F248-11E8-B48F-1D18A9856A87
last_name: O'Neill
- first_name: Jozsef L
full_name: Csicsvari, Jozsef L
id: 3FA14672-F248-11E8-B48F-1D18A9856A87
last_name: Csicsvari
orcid: 0000-0002-5193-4036
citation:
ama: Xu H, Baracskay P, O’Neill J, Csicsvari JL. Assembly responses of hippocampal
CA1 place cells predict learned behavior in goal-directed spatial tasks on the
radial eight-arm maze. Neuron. 2019;101(1):119-132.e4. doi:10.1016/j.neuron.2018.11.015
apa: Xu, H., Baracskay, P., O’Neill, J., & Csicsvari, J. L. (2019). Assembly
responses of hippocampal CA1 place cells predict learned behavior in goal-directed
spatial tasks on the radial eight-arm maze. Neuron. Elsevier. https://doi.org/10.1016/j.neuron.2018.11.015
chicago: Xu, Haibing, Peter Baracskay, Joseph O’Neill, and Jozsef L Csicsvari. “Assembly
Responses of Hippocampal CA1 Place Cells Predict Learned Behavior in Goal-Directed
Spatial Tasks on the Radial Eight-Arm Maze.” Neuron. Elsevier, 2019. https://doi.org/10.1016/j.neuron.2018.11.015.
ieee: H. Xu, P. Baracskay, J. O’Neill, and J. L. Csicsvari, “Assembly responses
of hippocampal CA1 place cells predict learned behavior in goal-directed spatial
tasks on the radial eight-arm maze,” Neuron, vol. 101, no. 1. Elsevier,
p. 119–132.e4, 2019.
ista: Xu H, Baracskay P, O’Neill J, Csicsvari JL. 2019. Assembly responses of hippocampal
CA1 place cells predict learned behavior in goal-directed spatial tasks on the
radial eight-arm maze. Neuron. 101(1), 119–132.e4.
mla: Xu, Haibing, et al. “Assembly Responses of Hippocampal CA1 Place Cells Predict
Learned Behavior in Goal-Directed Spatial Tasks on the Radial Eight-Arm Maze.”
Neuron, vol. 101, no. 1, Elsevier, 2019, p. 119–132.e4, doi:10.1016/j.neuron.2018.11.015.
short: H. Xu, P. Baracskay, J. O’Neill, J.L. Csicsvari, Neuron 101 (2019) 119–132.e4.
date_created: 2019-01-13T22:59:10Z
date_published: 2019-01-02T00:00:00Z
date_updated: 2023-09-07T12:06:37Z
day: '02'
department:
- _id: JoCs
doi: 10.1016/j.neuron.2018.11.015
ec_funded: 1
external_id:
isi:
- '000454791500014'
intvolume: ' 101'
isi: 1
issue: '1'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.doi.org/10.1016/j.neuron.2018.11.015
month: '01'
oa: 1
oa_version: Published Version
page: 119-132.e4
project:
- _id: 257A4776-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '281511'
name: Memory-related information processing in neuronal circuits of the hippocampus
and entorhinal cortex
publication: Neuron
publication_identifier:
issn:
- '10974199'
publication_status: published
publisher: Elsevier
quality_controlled: '1'
related_material:
link:
- description: News on IST Homepage
relation: press_release
url: https://ist.ac.at/en/news/reading-rats-minds/
record:
- id: '837'
relation: dissertation_contains
status: public
scopus_import: '1'
status: public
title: Assembly responses of hippocampal CA1 place cells predict learned behavior
in goal-directed spatial tasks on the radial eight-arm maze
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 101
year: '2019'
...
---
_id: '6194'
abstract:
- lang: eng
text: Grid cells with their rigid hexagonal firing fields are thought to provide
an invariant metric to the hippocampal cognitive map, yet environmental geometrical
features have recently been shown to distort the grid structure. Given that the
hippocampal role goes beyond space, we tested the influence of nonspatial information
on the grid organization. We trained rats to daily learn three new reward locations
on a cheeseboard maze while recording from the medial entorhinal cortex and the
hippocampal CA1 region. Many grid fields moved toward goal location, leading to
long-lasting deformations of the entorhinal map. Therefore, distortions in the
grid structure contribute to goal representation during both learning and recall,
which demonstrates that grid cells participate in mnemonic coding and do not merely
provide a simple metric of space.
article_processing_charge: No
article_type: original
author:
- first_name: Charlotte N.
full_name: Boccara, Charlotte N.
id: 3FC06552-F248-11E8-B48F-1D18A9856A87
last_name: Boccara
orcid: 0000-0001-7237-5109
- first_name: Michele
full_name: Nardin, Michele
id: 30BD0376-F248-11E8-B48F-1D18A9856A87
last_name: Nardin
orcid: 0000-0001-8849-6570
- first_name: Federico
full_name: Stella, Federico
id: 39AF1E74-F248-11E8-B48F-1D18A9856A87
last_name: Stella
orcid: 0000-0001-9439-3148
- first_name: Joseph
full_name: O'Neill, Joseph
id: 426376DC-F248-11E8-B48F-1D18A9856A87
last_name: O'Neill
- first_name: Jozsef L
full_name: Csicsvari, Jozsef L
id: 3FA14672-F248-11E8-B48F-1D18A9856A87
last_name: Csicsvari
orcid: 0000-0002-5193-4036
citation:
ama: Boccara CN, Nardin M, Stella F, O’Neill J, Csicsvari JL. The entorhinal cognitive
map is attracted to goals. Science. 2019;363(6434):1443-1447. doi:10.1126/science.aav4837
apa: Boccara, C. N., Nardin, M., Stella, F., O’Neill, J., & Csicsvari, J. L.
(2019). The entorhinal cognitive map is attracted to goals. Science. American
Association for the Advancement of Science. https://doi.org/10.1126/science.aav4837
chicago: Boccara, Charlotte N., Michele Nardin, Federico Stella, Joseph O’Neill,
and Jozsef L Csicsvari. “The Entorhinal Cognitive Map Is Attracted to Goals.”
Science. American Association for the Advancement of Science, 2019. https://doi.org/10.1126/science.aav4837.
ieee: C. N. Boccara, M. Nardin, F. Stella, J. O’Neill, and J. L. Csicsvari, “The
entorhinal cognitive map is attracted to goals,” Science, vol. 363, no.
6434. American Association for the Advancement of Science, pp. 1443–1447, 2019.
ista: Boccara CN, Nardin M, Stella F, O’Neill J, Csicsvari JL. 2019. The entorhinal
cognitive map is attracted to goals. Science. 363(6434), 1443–1447.
mla: Boccara, Charlotte N., et al. “The Entorhinal Cognitive Map Is Attracted to
Goals.” Science, vol. 363, no. 6434, American Association for the Advancement
of Science, 2019, pp. 1443–47, doi:10.1126/science.aav4837.
short: C.N. Boccara, M. Nardin, F. Stella, J. O’Neill, J.L. Csicsvari, Science 363
(2019) 1443–1447.
date_created: 2019-04-04T08:39:30Z
date_published: 2019-03-29T00:00:00Z
date_updated: 2024-03-25T23:30:09Z
day: '29'
ddc:
- '570'
department:
- _id: JoCs
doi: 10.1126/science.aav4837
ec_funded: 1
external_id:
isi:
- '000462738000034'
file:
- access_level: open_access
checksum: 5e6b16742cde10a560cfaf2130764da1
content_type: application/pdf
creator: dernst
date_created: 2020-05-14T09:11:10Z
date_updated: 2020-07-14T12:47:23Z
file_id: '7826'
file_name: 2019_Science_Boccara.pdf
file_size: 9045923
relation: main_file
file_date_updated: 2020-07-14T12:47:23Z
has_accepted_license: '1'
intvolume: ' 363'
isi: 1
issue: '6434'
language:
- iso: eng
month: '03'
oa: 1
oa_version: Submitted Version
page: 1443-1447
project:
- _id: 257A4776-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '281511'
name: Memory-related information processing in neuronal circuits of the hippocampus
and entorhinal cortex
- _id: 2564DBCA-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '665385'
name: International IST Doctoral Program
publication: Science
publication_identifier:
eissn:
- 1095-9203
issn:
- 0036-8075
publication_status: published
publisher: American Association for the Advancement of Science
quality_controlled: '1'
related_material:
link:
- description: News on IST Homepage
relation: press_release
url: https://ist.ac.at/en/news/grid-cells-create-treasure-map-in-rat-brain/
record:
- id: '6062'
relation: popular_science
status: public
- id: '11932'
relation: dissertation_contains
status: public
scopus_import: '1'
status: public
title: The entorhinal cognitive map is attracted to goals
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 363
year: '2019'
...
---
_id: '6338'
abstract:
- lang: eng
text: Hippocampal activity patterns representing movement trajectories are reactivated
in immobility and sleep periods, a process associated with memory recall, consolidation,
and decision making. It is thought that only fixed, behaviorally relevant patterns
can be reactivated, which are stored across hippocampal synaptic connections.
To test whether some generalized rules govern reactivation, we examined trajectory
reactivation following non-stereotypical exploration of familiar open-field environments.
We found that random trajectories of varying lengths and timescales were reactivated,
resembling that of Brownian motion of particles. The animals’ behavioral trajectory
did not follow Brownian diffusion demonstrating that the exact behavioral experience
is not reactivated. Therefore, hippocampal circuits are able to generate random
trajectories of any recently active map by following diffusion dynamics. This
ability of hippocampal circuits to generate representations of all behavioral
outcome combinations, experienced or not, may underlie a wide variety of hippocampal-dependent
cognitive functions such as learning, generalization, and planning.
article_processing_charge: No
article_type: original
author:
- first_name: Federico
full_name: Stella, Federico
id: 39AF1E74-F248-11E8-B48F-1D18A9856A87
last_name: Stella
orcid: 0000-0001-9439-3148
- first_name: Peter
full_name: Baracskay, Peter
id: 361CC00E-F248-11E8-B48F-1D18A9856A87
last_name: Baracskay
- first_name: Joseph
full_name: O'Neill, Joseph
id: 426376DC-F248-11E8-B48F-1D18A9856A87
last_name: O'Neill
- first_name: Jozsef L
full_name: Csicsvari, Jozsef L
id: 3FA14672-F248-11E8-B48F-1D18A9856A87
last_name: Csicsvari
orcid: 0000-0002-5193-4036
citation:
ama: Stella F, Baracskay P, O’Neill J, Csicsvari JL. Hippocampal reactivation of
random trajectories resembling Brownian diffusion. Neuron. 2019;102:450-461.
doi:10.1016/j.neuron.2019.01.052
apa: Stella, F., Baracskay, P., O’Neill, J., & Csicsvari, J. L. (2019). Hippocampal
reactivation of random trajectories resembling Brownian diffusion. Neuron.
Elsevier. https://doi.org/10.1016/j.neuron.2019.01.052
chicago: Stella, Federico, Peter Baracskay, Joseph O’Neill, and Jozsef L Csicsvari.
“Hippocampal Reactivation of Random Trajectories Resembling Brownian Diffusion.”
Neuron. Elsevier, 2019. https://doi.org/10.1016/j.neuron.2019.01.052.
ieee: F. Stella, P. Baracskay, J. O’Neill, and J. L. Csicsvari, “Hippocampal reactivation
of random trajectories resembling Brownian diffusion,” Neuron, vol. 102.
Elsevier, pp. 450–461, 2019.
ista: Stella F, Baracskay P, O’Neill J, Csicsvari JL. 2019. Hippocampal reactivation
of random trajectories resembling Brownian diffusion. Neuron. 102, 450–461.
mla: Stella, Federico, et al. “Hippocampal Reactivation of Random Trajectories Resembling
Brownian Diffusion.” Neuron, vol. 102, Elsevier, 2019, pp. 450–61, doi:10.1016/j.neuron.2019.01.052.
short: F. Stella, P. Baracskay, J. O’Neill, J.L. Csicsvari, Neuron 102 (2019) 450–461.
date_created: 2019-04-17T08:28:59Z
date_published: 2019-04-17T00:00:00Z
date_updated: 2023-08-25T10:13:07Z
day: '17'
department:
- _id: JoCs
doi: 10.1016/j.neuron.2019.01.052
ec_funded: 1
external_id:
isi:
- '000465169700017'
pmid:
- '30819547'
intvolume: ' 102'
isi: 1
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1016/j.neuron.2019.01.052
month: '04'
oa: 1
oa_version: Published Version
page: 450-461
pmid: 1
project:
- _id: 257A4776-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '281511'
name: Memory-related information processing in neuronal circuits of the hippocampus
and entorhinal cortex
- _id: 2654F984-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: I03713
name: Interneuro Plasticity During Spatial Learning
publication: Neuron
publication_status: published
publisher: Elsevier
quality_controlled: '1'
related_material:
link:
- description: News on IST Homepage
relation: press_release
url: https://ist.ac.at/en/news/memories-of-movement-are-replayed-randomly-during-sleep/
scopus_import: '1'
status: public
title: Hippocampal reactivation of random trajectories resembling Brownian diffusion
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 102
year: '2019'
...
---
_id: '1132'
abstract:
- lang: eng
text: The hippocampus is thought to initiate systems-wide mnemonic processes through
the reactivation of previously acquired spatial and episodic memory traces, which
can recruit the entorhinal cortex as a first stage of memory redistribution to
other brain areas. Hippocampal reactivation occurs during sharp wave-ripples,
in which synchronous network firing encodes sequences of places.We investigated
the coordination of this replay by recording assembly activity simultaneously
in the CA1 region of the hippocampus and superficial layers of the medial entorhinal
cortex. We found that entorhinal cell assemblies can replay trajectories independently
of the hippocampus and sharp wave-ripples. This suggests that the hippocampus
is not the sole initiator of spatial and episodic memory trace reactivation. Memory
systems involved in these processes may include nonhierarchical, parallel components.
article_processing_charge: No
author:
- first_name: Joseph
full_name: O'Neill, Joseph
id: 426376DC-F248-11E8-B48F-1D18A9856A87
last_name: O'Neill
- first_name: Charlotte
full_name: Boccara, Charlotte
id: 3FC06552-F248-11E8-B48F-1D18A9856A87
last_name: Boccara
orcid: 0000-0001-7237-5109
- first_name: Federico
full_name: Stella, Federico
id: 39AF1E74-F248-11E8-B48F-1D18A9856A87
last_name: Stella
orcid: 0000-0001-9439-3148
- first_name: Philipp
full_name: Schönenberger, Philipp
id: 3B9D816C-F248-11E8-B48F-1D18A9856A87
last_name: Schönenberger
- first_name: Jozsef L
full_name: Csicsvari, Jozsef L
id: 3FA14672-F248-11E8-B48F-1D18A9856A87
last_name: Csicsvari
orcid: 0000-0002-5193-4036
citation:
ama: O’Neill J, Boccara CN, Stella F, Schönenberger P, Csicsvari JL. Superficial
layers of the medial entorhinal cortex replay independently of the hippocampus.
Science. 2017;355(6321):184-188. doi:10.1126/science.aag2787
apa: O’Neill, J., Boccara, C. N., Stella, F., Schönenberger, P., & Csicsvari,
J. L. (2017). Superficial layers of the medial entorhinal cortex replay independently
of the hippocampus. Science. American Association for the Advancement of
Science. https://doi.org/10.1126/science.aag2787
chicago: O’Neill, Joseph, Charlotte N. Boccara, Federico Stella, Philipp Schönenberger,
and Jozsef L Csicsvari. “Superficial Layers of the Medial Entorhinal Cortex Replay
Independently of the Hippocampus.” Science. American Association for the
Advancement of Science, 2017. https://doi.org/10.1126/science.aag2787.
ieee: J. O’Neill, C. N. Boccara, F. Stella, P. Schönenberger, and J. L. Csicsvari,
“Superficial layers of the medial entorhinal cortex replay independently of the
hippocampus,” Science, vol. 355, no. 6321. American Association for the
Advancement of Science, pp. 184–188, 2017.
ista: O’Neill J, Boccara CN, Stella F, Schönenberger P, Csicsvari JL. 2017. Superficial
layers of the medial entorhinal cortex replay independently of the hippocampus.
Science. 355(6321), 184–188.
mla: O’Neill, Joseph, et al. “Superficial Layers of the Medial Entorhinal Cortex
Replay Independently of the Hippocampus.” Science, vol. 355, no. 6321,
American Association for the Advancement of Science, 2017, pp. 184–88, doi:10.1126/science.aag2787.
short: J. O’Neill, C.N. Boccara, F. Stella, P. Schönenberger, J.L. Csicsvari, Science
355 (2017) 184–188.
date_created: 2018-12-11T11:50:19Z
date_published: 2017-01-13T00:00:00Z
date_updated: 2023-09-20T11:30:35Z
day: '13'
ddc:
- '571'
department:
- _id: JoCs
doi: 10.1126/science.aag2787
ec_funded: 1
external_id:
isi:
- '000391743700044'
file:
- access_level: open_access
content_type: application/pdf
creator: system
date_created: 2018-12-12T10:10:22Z
date_updated: 2018-12-12T10:10:22Z
file_id: '4809'
file_name: IST-2018-976-v1+1_2017Preprint_ONeill_Superficial_layers.pdf
file_size: 3761201
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file_date_updated: 2018-12-12T10:10:22Z
has_accepted_license: '1'
intvolume: ' 355'
isi: 1
issue: '6321'
language:
- iso: eng
month: '01'
oa: 1
oa_version: Submitted Version
page: 184 - 188
project:
- _id: 257A4776-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '281511'
name: Memory-related information processing in neuronal circuits of the hippocampus
and entorhinal cortex
publication: Science
publication_identifier:
issn:
- '00368075'
publication_status: published
publisher: American Association for the Advancement of Science
publist_id: '6226'
pubrep_id: '976'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Superficial layers of the medial entorhinal cortex replay independently of
the hippocampus
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 355
year: '2017'
...
---
_id: '1334'
abstract:
- lang: eng
text: Hippocampal neurons encode a cognitive map of space. These maps are thought
to be updated during learning and in response to changes in the environment through
activity-dependent synaptic plasticity. Here we examine how changes in activity
influence spatial coding in rats using halorhodopsin-mediated, spatially selective
optogenetic silencing. Halorhoposin stimulation leads to light-induced suppression
in many place cells and interneurons; some place cells increase their firing through
disinhibition, whereas some show no effect. We find that place fields of the unaffected
subpopulation remain stable. On the other hand, place fields of suppressed place
cells were unstable, showing remapping across sessions before and after optogenetic
inhibition. Disinhibited place cells had stable maps but sustained an elevated
firing rate. These findings suggest that place representation in the hippocampus
is constantly governed by activity-dependent processes, and that disinhibition
may provide a mechanism for rate remapping.
article_number: '11824'
author:
- first_name: Philipp
full_name: Schönenberger, Philipp
id: 3B9D816C-F248-11E8-B48F-1D18A9856A87
last_name: Schönenberger
- first_name: Joseph
full_name: O'Neill, Joseph
id: 426376DC-F248-11E8-B48F-1D18A9856A87
last_name: O'Neill
- first_name: Jozsef L
full_name: Csicsvari, Jozsef L
id: 3FA14672-F248-11E8-B48F-1D18A9856A87
last_name: Csicsvari
orcid: 0000-0002-5193-4036
citation:
ama: Schönenberger P, O’Neill J, Csicsvari JL. Activity dependent plasticity of
hippocampal place maps. Nature Communications. 2016;7. doi:10.1038/ncomms11824
apa: Schönenberger, P., O’Neill, J., & Csicsvari, J. L. (2016). Activity dependent
plasticity of hippocampal place maps. Nature Communications. Nature Publishing
Group. https://doi.org/10.1038/ncomms11824
chicago: Schönenberger, Philipp, Joseph O’Neill, and Jozsef L Csicsvari. “Activity
Dependent Plasticity of Hippocampal Place Maps.” Nature Communications.
Nature Publishing Group, 2016. https://doi.org/10.1038/ncomms11824.
ieee: P. Schönenberger, J. O’Neill, and J. L. Csicsvari, “Activity dependent plasticity
of hippocampal place maps,” Nature Communications, vol. 7. Nature Publishing
Group, 2016.
ista: Schönenberger P, O’Neill J, Csicsvari JL. 2016. Activity dependent plasticity
of hippocampal place maps. Nature Communications. 7, 11824.
mla: Schönenberger, Philipp, et al. “Activity Dependent Plasticity of Hippocampal
Place Maps.” Nature Communications, vol. 7, 11824, Nature Publishing Group,
2016, doi:10.1038/ncomms11824.
short: P. Schönenberger, J. O’Neill, J.L. Csicsvari, Nature Communications 7 (2016).
date_created: 2018-12-11T11:51:26Z
date_published: 2016-06-10T00:00:00Z
date_updated: 2021-01-12T06:49:57Z
day: '10'
ddc:
- '570'
department:
- _id: JoCs
doi: 10.1038/ncomms11824
ec_funded: 1
file:
- access_level: open_access
checksum: e43307754abe65b840a21939fe163618
content_type: application/pdf
creator: system
date_created: 2018-12-12T10:16:10Z
date_updated: 2020-07-14T12:44:44Z
file_id: '5196'
file_name: IST-2016-660-v1+1_ncomms11824.pdf
file_size: 1793846
relation: main_file
file_date_updated: 2020-07-14T12:44:44Z
has_accepted_license: '1'
intvolume: ' 7'
language:
- iso: eng
month: '06'
oa: 1
oa_version: Published Version
project:
- _id: 257A4776-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '281511'
name: Memory-related information processing in neuronal circuits of the hippocampus
and entorhinal cortex
- _id: 257D4372-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: I2072-B27
name: Interneuron plasticity during spatial learning
publication: Nature Communications
publication_status: published
publisher: Nature Publishing Group
publist_id: '5934'
pubrep_id: '660'
quality_controlled: '1'
scopus_import: 1
status: public
title: Activity dependent plasticity of hippocampal place maps
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 3E5EF7F0-F248-11E8-B48F-1D18A9856A87
volume: 7
year: '2016'
...
---
_id: '1279'
abstract:
- lang: eng
text: During hippocampal sharp wave/ripple (SWR) events, previously occurring, sensory
inputdriven neuronal firing patterns are replayed. Such replay is thought to be
important for plasticity- related processes and consolidation of memory traces.
It has previously been shown that the electrical stimulation-induced disruption
of SWR events interferes with learning in rodents in different experimental paradigms.
On the other hand, the cognitive map theory posits that the plastic changes of
the firing of hippocampal place cells constitute the electrophysiological counterpart
of the spatial learning, observable at the behavioral level. Therefore, we tested
whether intact SWR events occurring during the sleep/rest session after the first
exploration of a novel environment are needed for the stabilization of the CA1
code, which process requires plasticity. We found that the newly-formed representation
in the CA1 has the same level of stability with optogenetic SWR blockade as with
a control manipulation that delivered the same amount of light into the brain.
Therefore our results suggest that at least in the case of passive exploratory
behavior, SWR-related plasticity is dispensable for the stability of CA1 ensembles.
acknowledgement: 'The research leading to these results has received funding from
the People Programme (Marie Curie Actions) of the European Union''s Seventh Framework
Programme (FP7/2007-2013) under REA grant agreement n° [291734] via the IST FELLOWSHIP
awarded to Dr. Krisztián A. Kovács and the European Research Council starting grant
(acronym: HIPECMEM Project reference: 281511) awarded to Dr. Jozsef Csicsvari. We
thank Lauri Viljanto for technical help in building the ripple detector.'
article_number: e0164675
author:
- first_name: Krisztián
full_name: Kovács, Krisztián
id: 2AB5821E-F248-11E8-B48F-1D18A9856A87
last_name: Kovács
- first_name: Joseph
full_name: O'Neill, Joseph
id: 426376DC-F248-11E8-B48F-1D18A9856A87
last_name: O'Neill
- first_name: Philipp
full_name: Schönenberger, Philipp
id: 3B9D816C-F248-11E8-B48F-1D18A9856A87
last_name: Schönenberger
- first_name: Markku
full_name: Penttonen, Markku
last_name: Penttonen
- first_name: Dámaris K
full_name: Rangel Guerrero, Dámaris K
id: 4871BCE6-F248-11E8-B48F-1D18A9856A87
last_name: Rangel Guerrero
orcid: 0000-0002-8602-4374
- first_name: Jozsef L
full_name: Csicsvari, Jozsef L
id: 3FA14672-F248-11E8-B48F-1D18A9856A87
last_name: Csicsvari
orcid: 0000-0002-5193-4036
citation:
ama: Kovács K, O’Neill J, Schönenberger P, Penttonen M, Rangel Guerrero DK, Csicsvari
JL. Optogenetically blocking sharp wave ripple events in sleep does not interfere
with the formation of stable spatial representation in the CA1 area of the hippocampus.
PLoS One. 2016;11(10). doi:10.1371/journal.pone.0164675
apa: Kovács, K., O’Neill, J., Schönenberger, P., Penttonen, M., Rangel Guerrero,
D. K., & Csicsvari, J. L. (2016). Optogenetically blocking sharp wave ripple
events in sleep does not interfere with the formation of stable spatial representation
in the CA1 area of the hippocampus. PLoS One. Public Library of Science.
https://doi.org/10.1371/journal.pone.0164675
chicago: Kovács, Krisztián, Joseph O’Neill, Philipp Schönenberger, Markku Penttonen,
Dámaris K Rangel Guerrero, and Jozsef L Csicsvari. “Optogenetically Blocking Sharp
Wave Ripple Events in Sleep Does Not Interfere with the Formation of Stable Spatial
Representation in the CA1 Area of the Hippocampus.” PLoS One. Public Library
of Science, 2016. https://doi.org/10.1371/journal.pone.0164675.
ieee: K. Kovács, J. O’Neill, P. Schönenberger, M. Penttonen, D. K. Rangel Guerrero,
and J. L. Csicsvari, “Optogenetically blocking sharp wave ripple events in sleep
does not interfere with the formation of stable spatial representation in the
CA1 area of the hippocampus,” PLoS One, vol. 11, no. 10. Public Library
of Science, 2016.
ista: Kovács K, O’Neill J, Schönenberger P, Penttonen M, Rangel Guerrero DK, Csicsvari
JL. 2016. Optogenetically blocking sharp wave ripple events in sleep does not
interfere with the formation of stable spatial representation in the CA1 area
of the hippocampus. PLoS One. 11(10), e0164675.
mla: Kovács, Krisztián, et al. “Optogenetically Blocking Sharp Wave Ripple Events
in Sleep Does Not Interfere with the Formation of Stable Spatial Representation
in the CA1 Area of the Hippocampus.” PLoS One, vol. 11, no. 10, e0164675,
Public Library of Science, 2016, doi:10.1371/journal.pone.0164675.
short: K. Kovács, J. O’Neill, P. Schönenberger, M. Penttonen, D.K. Rangel Guerrero,
J.L. Csicsvari, PLoS One 11 (2016).
date_created: 2018-12-11T11:51:06Z
date_published: 2016-10-19T00:00:00Z
date_updated: 2021-01-12T06:49:35Z
day: '19'
ddc:
- '570'
- '571'
department:
- _id: JoCs
doi: 10.1371/journal.pone.0164675
ec_funded: 1
file:
- access_level: open_access
checksum: 395895ecb2216e9c39135abaa56b28b3
content_type: application/pdf
creator: system
date_created: 2018-12-12T10:13:26Z
date_updated: 2020-07-14T12:44:42Z
file_id: '5009'
file_name: IST-2016-690-v1+1_journal.pone.0164675.PDF
file_size: 4353592
relation: main_file
file_date_updated: 2020-07-14T12:44:42Z
has_accepted_license: '1'
intvolume: ' 11'
issue: '10'
language:
- iso: eng
month: '10'
oa: 1
oa_version: Published Version
project:
- _id: 25681D80-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '291734'
name: International IST Postdoc Fellowship Programme
- _id: 257A4776-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '281511'
name: Memory-related information processing in neuronal circuits of the hippocampus
and entorhinal cortex
publication: PLoS One
publication_status: published
publisher: Public Library of Science
publist_id: '6037'
pubrep_id: '690'
quality_controlled: '1'
scopus_import: 1
status: public
title: Optogenetically blocking sharp wave ripple events in sleep does not interfere
with the formation of stable spatial representation in the CA1 area of the hippocampus
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 3E5EF7F0-F248-11E8-B48F-1D18A9856A87
volume: 11
year: '2016'
...
---
_id: '2003'
abstract:
- lang: eng
text: Learning can be facilitated by previous knowledge when it is organized into
relational representations forming schemas. In this issue of Neuron, McKenzie
et al. (2014) demonstrate that the hippocampus rapidly forms interrelated, hierarchical
memory representations to support schema-based learning.
author:
- first_name: Joseph
full_name: O'Neill, Joseph
id: 426376DC-F248-11E8-B48F-1D18A9856A87
last_name: O'Neill
- first_name: Jozsef L
full_name: Csicsvari, Jozsef L
id: 3FA14672-F248-11E8-B48F-1D18A9856A87
last_name: Csicsvari
orcid: 0000-0002-5193-4036
citation:
ama: O’Neill J, Csicsvari JL. Learning by example in the hippocampus. Neuron.
2014;83(1):8-10. doi:10.1016/j.neuron.2014.06.013
apa: O’Neill, J., & Csicsvari, J. L. (2014). Learning by example in the hippocampus.
Neuron. Elsevier. https://doi.org/10.1016/j.neuron.2014.06.013
chicago: O’Neill, Joseph, and Jozsef L Csicsvari. “Learning by Example in the Hippocampus.”
Neuron. Elsevier, 2014. https://doi.org/10.1016/j.neuron.2014.06.013.
ieee: J. O’Neill and J. L. Csicsvari, “Learning by example in the hippocampus,”
Neuron, vol. 83, no. 1. Elsevier, pp. 8–10, 2014.
ista: O’Neill J, Csicsvari JL. 2014. Learning by example in the hippocampus. Neuron.
83(1), 8–10.
mla: O’Neill, Joseph, and Jozsef L. Csicsvari. “Learning by Example in the Hippocampus.”
Neuron, vol. 83, no. 1, Elsevier, 2014, pp. 8–10, doi:10.1016/j.neuron.2014.06.013.
short: J. O’Neill, J.L. Csicsvari, Neuron 83 (2014) 8–10.
date_created: 2018-12-11T11:55:09Z
date_published: 2014-07-02T00:00:00Z
date_updated: 2021-01-12T06:54:39Z
day: '02'
department:
- _id: JoCs
doi: 10.1016/j.neuron.2014.06.013
intvolume: ' 83'
issue: '1'
language:
- iso: eng
month: '07'
oa_version: None
page: 8 - 10
publication: Neuron
publication_status: published
publisher: Elsevier
publist_id: '5073'
quality_controlled: '1'
scopus_import: 1
status: public
title: Learning by example in the hippocampus
type: journal_article
user_id: 4435EBFC-F248-11E8-B48F-1D18A9856A87
volume: 83
year: '2014'
...
---
_id: '2860'
abstract:
- lang: eng
text: 'In the hippocampus, cell assemblies forming mnemonic representations of space
are thought to arise as a result of changes in functional connections of pyramidal
cells. We have found that CA1 interneuron circuits are also reconfigured during
goal-oriented spatial learning through modification of inputs from pyramidal cells.
As learning progressed, new pyramidal assemblies expressed in theta cycles alternated
with previously established ones, and eventually overtook them. The firing patterns
of interneurons developed a relationship to new, learning-related assemblies:
some interneurons associated their activity with new pyramidal assemblies while
some others dissociated from them. These firing associations were explained by
changes in the weight of monosynaptic inputs received by interneurons from new
pyramidal assemblies, as these predicted the associational changes. Spatial learning
thus engages circuit modifications in the hippocampus that incorporate a redistribution
of inhibitory activity that might assist in the segregation of competing pyramidal
cell assembly patterns in space and time.'
acknowledgement: D.D. and J.C. were supported by a MRC Intramural Programme Grant
U138197111
author:
- first_name: David
full_name: Dupret, David
last_name: Dupret
- first_name: Joseph
full_name: O'Neill, Joseph
id: 426376DC-F248-11E8-B48F-1D18A9856A87
last_name: O'Neill
- first_name: Jozsef L
full_name: Csicsvari, Jozsef L
id: 3FA14672-F248-11E8-B48F-1D18A9856A87
last_name: Csicsvari
orcid: 0000-0002-5193-4036
citation:
ama: Dupret D, O’Neill J, Csicsvari JL. Dynamic reconfiguration of hippocampal interneuron
circuits during spatial learning. Neuron. 2013;78(1):166-180. doi:10.1016/j.neuron.2013.01.033
apa: Dupret, D., O’Neill, J., & Csicsvari, J. L. (2013). Dynamic reconfiguration
of hippocampal interneuron circuits during spatial learning. Neuron. Elsevier.
https://doi.org/10.1016/j.neuron.2013.01.033
chicago: Dupret, David, Joseph O’Neill, and Jozsef L Csicsvari. “Dynamic Reconfiguration
of Hippocampal Interneuron Circuits during Spatial Learning.” Neuron. Elsevier,
2013. https://doi.org/10.1016/j.neuron.2013.01.033.
ieee: D. Dupret, J. O’Neill, and J. L. Csicsvari, “Dynamic reconfiguration of hippocampal
interneuron circuits during spatial learning,” Neuron, vol. 78, no. 1.
Elsevier, pp. 166–180, 2013.
ista: Dupret D, O’Neill J, Csicsvari JL. 2013. Dynamic reconfiguration of hippocampal
interneuron circuits during spatial learning. Neuron. 78(1), 166–180.
mla: Dupret, David, et al. “Dynamic Reconfiguration of Hippocampal Interneuron Circuits
during Spatial Learning.” Neuron, vol. 78, no. 1, Elsevier, 2013, pp. 166–80,
doi:10.1016/j.neuron.2013.01.033.
short: D. Dupret, J. O’Neill, J.L. Csicsvari, Neuron 78 (2013) 166–180.
date_created: 2018-12-11T11:59:59Z
date_published: 2013-03-21T00:00:00Z
date_updated: 2021-01-12T07:00:19Z
day: '21'
ddc:
- '570'
department:
- _id: JoCs
doi: 10.1016/j.neuron.2013.01.033
ec_funded: 1
file:
- access_level: open_access
checksum: 0e18cb8561153ddb50bb5af16e7c9e97
content_type: application/pdf
creator: dernst
date_created: 2019-01-23T08:08:07Z
date_updated: 2020-07-14T12:45:52Z
file_id: '5877'
file_name: 2013_Neuron_Dupret.pdf
file_size: 2637837
relation: main_file
file_date_updated: 2020-07-14T12:45:52Z
has_accepted_license: '1'
intvolume: ' 78'
issue: '1'
language:
- iso: eng
month: '03'
oa: 1
oa_version: Published Version
page: 166 - 180
project:
- _id: 257A4776-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '281511'
name: Memory-related information processing in neuronal circuits of the hippocampus
and entorhinal cortex
publication: Neuron
publication_status: published
publisher: Elsevier
publist_id: '3929'
quality_controlled: '1'
scopus_import: 1
status: public
title: Dynamic reconfiguration of hippocampal interneuron circuits during spatial
learning
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 78
year: '2013'
...
---
_id: '3441'
abstract:
- lang: eng
text: The hippocampus is an important brain circuit for spatial memory and the spatially
selective spiking of hippocampal neuronal assemblies is thought to provide a mnemonic
representation of space. We found that remembering newly learnt goal locations
required NMDA receptorĝ€"dependent stabilization and enhanced reactivation
of goal-related hippocampal assemblies. During spatial learning, place-related
firing patterns in the CA1, but not CA3, region of the rat hippocampus were reorganized
to represent new goal locations. Such reorganization did not occur when goals
were marked by visual cues. The stabilization and successful retrieval of these
newly acquired CA1 representations of behaviorally relevant places was NMDAR dependent
and necessary for subsequent memory retention performance. Goal-related assembly
patterns associated with sharp wave/ripple network oscillations, during both learning
and subsequent rest periods, predicted memory performance. Together, these results
suggest that the reorganization and reactivation of assembly firing patterns in
the hippocampus represent the formation and expression of new spatial memory traces.
© 2010 Nature America, Inc. All rights reserved.
acknowledgement: |
Discussed in the News and Views section of the journal by Jeffery and Cacucci
author:
- first_name: David
full_name: Dupret, David
last_name: Dupret
- first_name: Joseph
full_name: Joseph O'Neill
id: 426376DC-F248-11E8-B48F-1D18A9856A87
last_name: O'Neill
- first_name: Barty
full_name: Pleydell-Bouverie, Barty
last_name: Pleydell Bouverie
- first_name: Jozsef L
full_name: Jozsef Csicsvari
id: 3FA14672-F248-11E8-B48F-1D18A9856A87
last_name: Csicsvari
orcid: 0000-0002-5193-4036
citation:
ama: Dupret D, O’Neill J, Pleydell Bouverie B, Csicsvari JL. The reorganization
and reactivation of hippocampal maps predict spatial memory performance. Nature
Neuroscience. 2010;13(8):995-1002. doi:10.1038/nn.2599
apa: Dupret, D., O’Neill, J., Pleydell Bouverie, B., & Csicsvari, J. L. (2010).
The reorganization and reactivation of hippocampal maps predict spatial memory
performance. Nature Neuroscience. Nature Publishing Group. https://doi.org/10.1038/nn.2599
chicago: Dupret, David, Joseph O’Neill, Barty Pleydell Bouverie, and Jozsef L Csicsvari.
“The Reorganization and Reactivation of Hippocampal Maps Predict Spatial Memory
Performance.” Nature Neuroscience. Nature Publishing Group, 2010. https://doi.org/10.1038/nn.2599.
ieee: D. Dupret, J. O’Neill, B. Pleydell Bouverie, and J. L. Csicsvari, “The reorganization
and reactivation of hippocampal maps predict spatial memory performance,” Nature
Neuroscience, vol. 13, no. 8. Nature Publishing Group, pp. 995–1002, 2010.
ista: Dupret D, O’Neill J, Pleydell Bouverie B, Csicsvari JL. 2010. The reorganization
and reactivation of hippocampal maps predict spatial memory performance. Nature
Neuroscience. 13(8), 995–1002.
mla: Dupret, David, et al. “The Reorganization and Reactivation of Hippocampal Maps
Predict Spatial Memory Performance.” Nature Neuroscience, vol. 13, no.
8, Nature Publishing Group, 2010, pp. 995–1002, doi:10.1038/nn.2599.
short: D. Dupret, J. O’Neill, B. Pleydell Bouverie, J.L. Csicsvari, Nature Neuroscience
13 (2010) 995–1002.
date_created: 2018-12-11T12:03:21Z
date_published: 2010-08-01T00:00:00Z
date_updated: 2021-01-12T07:43:29Z
day: '01'
doi: 10.1038/nn.2599
extern: 1
intvolume: ' 13'
issue: '8'
month: '08'
page: 995 - 1002
publication: Nature Neuroscience
publication_status: published
publisher: Nature Publishing Group
publist_id: '2946'
quality_controlled: 0
status: public
title: The reorganization and reactivation of hippocampal maps predict spatial memory
performance
type: journal_article
volume: 13
year: '2010'
...
---
_id: '3442'
abstract:
- lang: eng
text: Episodic and spatial memories each involve the encoding of complex associations
in hippocampal neuronal circuits. Such memory traces could be stabilised from
short- to long-term forms by consolidation processes involving the 'reactivation'
of the original network firing patterns during sleep and rest. Waking experience
can be replayed in many different brain areas, but an important role for the hippocampus
lies in the organisation of the 'reactivation' process. Emerging evidence suggests
that sharp wave/ripple (SWR) events in the hippocampus could coordinate the reactivation
of memory traces and direct their reinstatement in cortical circuits. Although
the mechanisms remain uncertain, there is a growing consensus that such SWR-directed
reactivation of brain-wide memory traces could underlie memory consolidation.
© 2010 Elsevier Ltd.
author:
- first_name: Joseph
full_name: Joseph O'Neill
id: 426376DC-F248-11E8-B48F-1D18A9856A87
last_name: O'Neill
- first_name: Barty
full_name: Pleydell-Bouverie, Barty
last_name: Pleydell Bouverie
- first_name: David
full_name: Dupret, David
last_name: Dupret
- first_name: Jozsef L
full_name: Jozsef Csicsvari
id: 3FA14672-F248-11E8-B48F-1D18A9856A87
last_name: Csicsvari
orcid: 0000-0002-5193-4036
citation:
ama: 'O’Neill J, Pleydell Bouverie B, Dupret D, Csicsvari JL. Play it again: reactivation
of waking experience and memory. Trends in Neurosciences. 2010;33(5):220-229.
doi:10.1016/j.tins.2010.01.006'
apa: 'O’Neill, J., Pleydell Bouverie, B., Dupret, D., & Csicsvari, J. L. (2010).
Play it again: reactivation of waking experience and memory. Trends in Neurosciences.
Elsevier. https://doi.org/10.1016/j.tins.2010.01.006'
chicago: 'O’Neill, Joseph, Barty Pleydell Bouverie, David Dupret, and Jozsef L Csicsvari.
“Play It Again: Reactivation of Waking Experience and Memory.” Trends in Neurosciences.
Elsevier, 2010. https://doi.org/10.1016/j.tins.2010.01.006.'
ieee: 'J. O’Neill, B. Pleydell Bouverie, D. Dupret, and J. L. Csicsvari, “Play it
again: reactivation of waking experience and memory,” Trends in Neurosciences,
vol. 33, no. 5. Elsevier, pp. 220–229, 2010.'
ista: 'O’Neill J, Pleydell Bouverie B, Dupret D, Csicsvari JL. 2010. Play it again:
reactivation of waking experience and memory. Trends in Neurosciences. 33(5),
220–229.'
mla: 'O’Neill, Joseph, et al. “Play It Again: Reactivation of Waking Experience
and Memory.” Trends in Neurosciences, vol. 33, no. 5, Elsevier, 2010, pp.
220–29, doi:10.1016/j.tins.2010.01.006.'
short: J. O’Neill, B. Pleydell Bouverie, D. Dupret, J.L. Csicsvari, Trends in Neurosciences
33 (2010) 220–229.
date_created: 2018-12-11T12:03:21Z
date_published: 2010-05-01T00:00:00Z
date_updated: 2021-01-12T07:43:29Z
day: '01'
doi: 10.1016/j.tins.2010.01.006
extern: 1
intvolume: ' 33'
issue: '5'
month: '05'
page: 220 - 229
publication: Trends in Neurosciences
publication_status: published
publisher: Elsevier
publist_id: '2945'
quality_controlled: 0
status: public
title: 'Play it again: reactivation of waking experience and memory'
type: journal_article
volume: 33
year: '2010'
...
---
_id: '3520'
abstract:
- lang: eng
text: The hippocampus is thought to be involved in episodic memory formation by
reactivating traces of waking experience during sleep. Indeed, the joint firing
of spatially tuned pyramidal cells encoding nearby places recur during sleep.
We found that the sleep cofiring of rat CA1 pyramidal cells encoding similar places
increased relative to the sleep session before exploration. This cofiring increase
depended on the number of times that cells fired together with short latencies
( < 50 ms) during exploration, and was strongest between cells representing
the most visited places. This is indicative of a Hebbian learning rule in which
changes in firing associations between cells are determined by the number of waking
coincident firing events. In contrast, cells encoding different locations reduced
their cofiring in proportion to the number of times that they fired independently.
Together these data indicate that reactivated patterns are shaped by both positive
and negative changes in cofiring, which are determined by recent behavior.
author:
- first_name: Joseph
full_name: Joseph O'Neill
id: 426376DC-F248-11E8-B48F-1D18A9856A87
last_name: O'Neill
- first_name: Timothy
full_name: Senior,Timothy J
last_name: Senior
- first_name: Kevin
full_name: Allen, Kevin
last_name: Allen
- first_name: John
full_name: Huxter,John R
last_name: Huxter
- first_name: Jozsef L
full_name: Jozsef Csicsvari
id: 3FA14672-F248-11E8-B48F-1D18A9856A87
last_name: Csicsvari
orcid: 0000-0002-5193-4036
citation:
ama: O’Neill J, Senior T, Allen K, Huxter J, Csicsvari JL. Reactivation of experience-dependent
cell assembly patterns in the hippocampus. Nature Neuroscience. 2008;11(2):209-215.
doi:10.1038/nn2037
apa: O’Neill, J., Senior, T., Allen, K., Huxter, J., & Csicsvari, J. L. (2008).
Reactivation of experience-dependent cell assembly patterns in the hippocampus.
Nature Neuroscience. Nature Publishing Group. https://doi.org/10.1038/nn2037
chicago: O’Neill, Joseph, Timothy Senior, Kevin Allen, John Huxter, and Jozsef L
Csicsvari. “Reactivation of Experience-Dependent Cell Assembly Patterns in the
Hippocampus.” Nature Neuroscience. Nature Publishing Group, 2008. https://doi.org/10.1038/nn2037.
ieee: J. O’Neill, T. Senior, K. Allen, J. Huxter, and J. L. Csicsvari, “Reactivation
of experience-dependent cell assembly patterns in the hippocampus,” Nature
Neuroscience, vol. 11, no. 2. Nature Publishing Group, pp. 209–215, 2008.
ista: O’Neill J, Senior T, Allen K, Huxter J, Csicsvari JL. 2008. Reactivation of
experience-dependent cell assembly patterns in the hippocampus. Nature Neuroscience.
11(2), 209–215.
mla: O’Neill, Joseph, et al. “Reactivation of Experience-Dependent Cell Assembly
Patterns in the Hippocampus.” Nature Neuroscience, vol. 11, no. 2, Nature
Publishing Group, 2008, pp. 209–15, doi:10.1038/nn2037.
short: J. O’Neill, T. Senior, K. Allen, J. Huxter, J.L. Csicsvari, Nature Neuroscience
11 (2008) 209–215.
date_created: 2018-12-11T12:03:46Z
date_published: 2008-02-01T00:00:00Z
date_updated: 2021-01-12T07:44:02Z
day: '01'
doi: 10.1038/nn2037
extern: 1
intvolume: ' 11'
issue: '2'
month: '02'
page: 209 - 215
publication: Nature Neuroscience
publication_status: published
publisher: Nature Publishing Group
publist_id: '2864'
quality_controlled: 0
status: public
title: Reactivation of experience-dependent cell assembly patterns in the hippocampus
type: journal_article
volume: 11
year: '2008'
...
---
_id: '3537'
abstract:
- lang: eng
text: 'Hippocampal place cells that fire together within the same cycle of theta
oscillations represent the sequence of positions (movement trajectory) that a
rat traverses on a linear track. Furthermore, it has been suggested that the encoding
of these and other types of temporal memory sequences is organized by gamma oscillations
nested within theta oscillations. Here, we examined whether gamma-related firing
of place cells permits such discrete temporal coding. We found that gamma-modulated
CA1 pyramidal cells separated into two classes on the basis of gamma firing phases
during waking theta periods. These groups also differed in terms of their spike
waveforms, firing rates, and burst firing tendency. During gamma oscillations
one group''s firing became restricted to theta phases associated with the highest
gamma power. Consequently, on the linear track, cells in this group often failed
to fire early in theta-phase precession (as the rat entered the place field) if
gamma oscillations were present. The second group fired throughout the theta cycle
during gamma oscillations, and maintained gamma-modulated firing at different
stages of theta-phase precession. Our results suggest that the two different pyramidal
cell classes may support different types of population codes within a theta cycle:
one in which spike sequences representing movement trajectories occur across subsequent
gamma cycles nested within each theta cycle, and another in which firing in synchronized
gamma discharges without temporal sequences encode a representation of location.
We propose that gamma oscillations during theta-phase precession organize the
mnemonic recall of population patterns representing places and movement paths.'
author:
- first_name: Timothy
full_name: Senior,Timothy J
last_name: Senior
- first_name: John
full_name: Huxter,John R
last_name: Huxter
- first_name: Kevin
full_name: Allen, Kevin
last_name: Allen
- first_name: Joseph
full_name: Joseph O'Neill
id: 426376DC-F248-11E8-B48F-1D18A9856A87
last_name: O'Neill
- first_name: Jozsef L
full_name: Jozsef Csicsvari
id: 3FA14672-F248-11E8-B48F-1D18A9856A87
last_name: Csicsvari
orcid: 0000-0002-5193-4036
citation:
ama: Senior T, Huxter J, Allen K, O’Neill J, Csicsvari JL. Gamma oscillatory firing
reveals distinct populations of pyramidal cells in the CA1 region of the hippocampus.
Journal of Neuroscience. 2008;28(9):2274-2286. doi:10.1523/JNEUROSCI.4669-07.2008
apa: Senior, T., Huxter, J., Allen, K., O’Neill, J., & Csicsvari, J. L. (2008).
Gamma oscillatory firing reveals distinct populations of pyramidal cells in the
CA1 region of the hippocampus. Journal of Neuroscience. Society for Neuroscience.
https://doi.org/10.1523/JNEUROSCI.4669-07.2008
chicago: Senior, Timothy, John Huxter, Kevin Allen, Joseph O’Neill, and Jozsef L
Csicsvari. “Gamma Oscillatory Firing Reveals Distinct Populations of Pyramidal
Cells in the CA1 Region of the Hippocampus.” Journal of Neuroscience. Society
for Neuroscience, 2008. https://doi.org/10.1523/JNEUROSCI.4669-07.2008.
ieee: T. Senior, J. Huxter, K. Allen, J. O’Neill, and J. L. Csicsvari, “Gamma oscillatory
firing reveals distinct populations of pyramidal cells in the CA1 region of the
hippocampus,” Journal of Neuroscience, vol. 28, no. 9. Society for Neuroscience,
pp. 2274–2286, 2008.
ista: Senior T, Huxter J, Allen K, O’Neill J, Csicsvari JL. 2008. Gamma oscillatory
firing reveals distinct populations of pyramidal cells in the CA1 region of the
hippocampus. Journal of Neuroscience. 28(9), 2274–2286.
mla: Senior, Timothy, et al. “Gamma Oscillatory Firing Reveals Distinct Populations
of Pyramidal Cells in the CA1 Region of the Hippocampus.” Journal of Neuroscience,
vol. 28, no. 9, Society for Neuroscience, 2008, pp. 2274–86, doi:10.1523/JNEUROSCI.4669-07.2008.
short: T. Senior, J. Huxter, K. Allen, J. O’Neill, J.L. Csicsvari, Journal of Neuroscience
28 (2008) 2274–2286.
date_created: 2018-12-11T12:03:51Z
date_published: 2008-02-27T00:00:00Z
date_updated: 2021-01-12T07:44:09Z
day: '27'
doi: 10.1523/JNEUROSCI.4669-07.2008
extern: 1
intvolume: ' 28'
issue: '9'
month: '02'
page: 2274 - 2286
publication: Journal of Neuroscience
publication_status: published
publisher: Society for Neuroscience
publist_id: '2847'
quality_controlled: 0
status: public
title: Gamma oscillatory firing reveals distinct populations of pyramidal cells in
the CA1 region of the hippocampus
type: journal_article
volume: 28
year: '2008'
...
---
_id: '3523'
abstract:
- lang: eng
text: On the linear track, the recent firing sequences of CA1 place cells recur
during sharp wave/ripple patterns (SWRs) in a reverse temporal order [Foster &
Wilson (2006) Nature, 440, 680-683]. We have found similar reverse-order reactivation
during SWRs in open-field exploration where the firing sequence of cells varied
before each SWR. Both the onset times and the firing patterns of cells showed
a tendency for reversed sequences during SWRs. These effects were observed for
SWRs that occurred during exploration, but not for those during longer immobility
periods. Additionally, reverse reactivation was stronger when it was preceded
by higher speed (> 5 cm/s) run periods. The trend for reverse-order SWR reactivation
was not significantly different in familiar and novel environments, even though
SWR-associated firing rates of both pyramidal cells and interneurons were reduced
in novel environments as compared with familiar. During exploration-associated
SWRs (eSWR) place cells retain place-selective firing [O'Neill et al. (2006) Neuron,
49, 143-155]. Here, we have shown that each cell's firing onset was more delayed
and firing probability more reduced during eSWRs the further the rat was from
the middle of the cell's place field; that is, cells receiving less momentary
place-related excitatory drive fired later during SWR events. However, even controlling
for place field distance, the recent firing of cells was still significantly correlated
with SWR reactivation sequences. We therefore propose that both place-related
drive and the firing history of cells contribute to reverse reactivation during
eSWRs.
author:
- first_name: Jozsef L
full_name: Jozsef Csicsvari
id: 3FA14672-F248-11E8-B48F-1D18A9856A87
last_name: Csicsvari
orcid: 0000-0002-5193-4036
- first_name: Joseph
full_name: Joseph O'Neill
id: 426376DC-F248-11E8-B48F-1D18A9856A87
last_name: O'Neill
- first_name: Kevin
full_name: Allen, Kevin
last_name: Allen
- first_name: Timothy
full_name: Senior,Timothy
last_name: Senior
citation:
ama: Csicsvari JL, O’Neill J, Allen K, Senior T. Place-selective firing contributes
to the reverse-order reactivation of CA1 pyramidal cells during sharp waves in
open-field exploration. European Journal of Neuroscience. 2007;26(3):704-716.
doi:10.1111/j.1460-9568.2007.05684.x
apa: Csicsvari, J. L., O’Neill, J., Allen, K., & Senior, T. (2007). Place-selective
firing contributes to the reverse-order reactivation of CA1 pyramidal cells during
sharp waves in open-field exploration. European Journal of Neuroscience.
Wiley-Blackwell. https://doi.org/10.1111/j.1460-9568.2007.05684.x
chicago: Csicsvari, Jozsef L, Joseph O’Neill, Kevin Allen, and Timothy Senior. “Place-Selective
Firing Contributes to the Reverse-Order Reactivation of CA1 Pyramidal Cells during
Sharp Waves in Open-Field Exploration.” European Journal of Neuroscience.
Wiley-Blackwell, 2007. https://doi.org/10.1111/j.1460-9568.2007.05684.x.
ieee: J. L. Csicsvari, J. O’Neill, K. Allen, and T. Senior, “Place-selective firing
contributes to the reverse-order reactivation of CA1 pyramidal cells during sharp
waves in open-field exploration,” European Journal of Neuroscience, vol.
26, no. 3. Wiley-Blackwell, pp. 704–716, 2007.
ista: Csicsvari JL, O’Neill J, Allen K, Senior T. 2007. Place-selective firing contributes
to the reverse-order reactivation of CA1 pyramidal cells during sharp waves in
open-field exploration. European Journal of Neuroscience. 26(3), 704–716.
mla: Csicsvari, Jozsef L., et al. “Place-Selective Firing Contributes to the Reverse-Order
Reactivation of CA1 Pyramidal Cells during Sharp Waves in Open-Field Exploration.”
European Journal of Neuroscience, vol. 26, no. 3, Wiley-Blackwell, 2007,
pp. 704–16, doi:10.1111/j.1460-9568.2007.05684.x.
short: J.L. Csicsvari, J. O’Neill, K. Allen, T. Senior, European Journal of Neuroscience
26 (2007) 704–716.
date_created: 2018-12-11T12:03:46Z
date_published: 2007-08-01T00:00:00Z
date_updated: 2021-01-12T07:44:03Z
day: '01'
doi: 10.1111/j.1460-9568.2007.05684.x
extern: 1
intvolume: ' 26'
issue: '3'
month: '08'
page: 704 - 716
publication: European Journal of Neuroscience
publication_status: published
publisher: Wiley-Blackwell
publist_id: '2862'
quality_controlled: 0
status: public
title: Place-selective firing contributes to the reverse-order reactivation of CA1
pyramidal cells during sharp waves in open-field exploration
type: journal_article
volume: 26
year: '2007'
...
---
_id: '3522'
abstract:
- lang: eng
text: We observed sharp wave/ripples (SWR) during exploration within brief (<
2.4 s) interruptions of or during theta oscillations. CA1 network responses of
SWRs occurring during exploration (eSWR) and SWRs detected in waking immobility
or sleep were similar. However, neuronal activity during eSWR was location dependent,
and eSWR-related firing was stronger inside the place field than outside. The
eSPW-related firing increase was stronger than the baseline increase inside compared
to outside, suggesting a “supralinear” summation of eSWR and place-selective inputs.
Pairs of cells with similar place fields and/or correlated firing during exploration
showed stronger coactivation during eSWRs and subsequent sleep-SWRs. Sequential
activation of place cells was not required for the reactivation of waking co-firing
patterns; cell pairs with symmetrical cross-correlations still showed reactivated
waking co-firing patterns during sleep-SWRs. We suggest that place-selective firing
during eSWRs facilitates initial associations between cells with similar place
fields that enable place-related ensemble patterns to recur during subsequent
sleep-SWRs.
author:
- first_name: Joseph
full_name: Joseph O'Neill
id: 426376DC-F248-11E8-B48F-1D18A9856A87
last_name: O'Neill
- first_name: Timothy
full_name: Senior,Timothy
last_name: Senior
- first_name: Jozsef L
full_name: Jozsef Csicsvari
id: 3FA14672-F248-11E8-B48F-1D18A9856A87
last_name: Csicsvari
orcid: 0000-0002-5193-4036
citation:
ama: O’Neill J, Senior T, Csicsvari JL. Place-selective firing of CA1 pyramidal
cells during sharp wave/ripple network patterns in exploratory behavior. Neuron.
2006;49(1):143-155. doi:10.1016/j.neuron.2005.10.037
apa: O’Neill, J., Senior, T., & Csicsvari, J. L. (2006). Place-selective firing
of CA1 pyramidal cells during sharp wave/ripple network patterns in exploratory
behavior. Neuron. Elsevier. https://doi.org/10.1016/j.neuron.2005.10.037
chicago: O’Neill, Joseph, Timothy Senior, and Jozsef L Csicsvari. “Place-Selective
Firing of CA1 Pyramidal Cells during Sharp Wave/Ripple Network Patterns in Exploratory
Behavior.” Neuron. Elsevier, 2006. https://doi.org/10.1016/j.neuron.2005.10.037.
ieee: J. O’Neill, T. Senior, and J. L. Csicsvari, “Place-selective firing of CA1
pyramidal cells during sharp wave/ripple network patterns in exploratory behavior,”
Neuron, vol. 49, no. 1. Elsevier, pp. 143–155, 2006.
ista: O’Neill J, Senior T, Csicsvari JL. 2006. Place-selective firing of CA1 pyramidal
cells during sharp wave/ripple network patterns in exploratory behavior. Neuron.
49(1), 143–155.
mla: O’Neill, Joseph, et al. “Place-Selective Firing of CA1 Pyramidal Cells during
Sharp Wave/Ripple Network Patterns in Exploratory Behavior.” Neuron, vol.
49, no. 1, Elsevier, 2006, pp. 143–55, doi:10.1016/j.neuron.2005.10.037.
short: J. O’Neill, T. Senior, J.L. Csicsvari, Neuron 49 (2006) 143–155.
date_created: 2018-12-11T12:03:46Z
date_published: 2006-01-05T00:00:00Z
date_updated: 2021-01-12T07:44:03Z
day: '05'
doi: 10.1016/j.neuron.2005.10.037
extern: 1
intvolume: ' 49'
issue: '1'
month: '01'
page: 143 - 155
publication: Neuron
publication_status: published
publisher: Elsevier
publist_id: '2863'
quality_controlled: 0
status: public
title: Place-selective firing of CA1 pyramidal cells during sharp wave/ripple network
patterns in exploratory behavior
type: journal_article
volume: 49
year: '2006'
...
---
_id: '3443'
abstract:
- lang: eng
text: In the hippocampal CA1 area, a relatively homogenous population of pyramidal
cells is accompanied by a diversity of GABAergic interneurons. Previously, we
found that parvalbumin-expressing basket, axo-axonic, bistratified, and oriens-lacunosum
moleculare cells, innervating different domains of pyramidal cells, have distinct
firing patterns during network oscillations in vivo. A second family of interneurons,
expressing cholecystokinin but not parvalbumin, is known to target the same domains
of pyramidal cells as do the parvalbumin cells. To test the temporal activity
of these independent and parallel GABAergic inputs, we recorded the precise spike
timing of identified cholecystokinin interneurons during hippocampal network oscillations
in anesthetized rats and determined their molecular expression profiles and synaptic
targets. The cells were cannabinoid receptor type 1 immunopositive. Contrary to
the stereotyped firing of parvalbumin interneurons, cholecystokinin-expressing
basket and dendrite-innervating cells discharge, on average, with 1.7 ± 2.0 Hz
during high-frequency ripple oscillations in an episode-dependent manner. During
theta oscillations, cholecystokinin- expressing interneurons fire with 8.8 ± 3.3
Hz at a characteristic time on the ascending phase of theta waves (155 ± 81°),
when place cells start firing in freely moving animals. The firing patterns of
some interneurons recorded in drug-free behaving rats were similar to cholecystokinin
cells in anesthetized animals. Our results demonstrate that cholecystokinin- and
parvalbumin-expressing interneurons make different contributions to network oscillations
and play distinct roles in different brain states. We suggest that the specific
spike timing of cholecystokinin interneurons and their sensitivity to endocannabinoids
might contribute to differentiate subgroups of pyramidal cells forming neuronal
assemblies, whereas parvalbumin interneurons contribute to synchronizing the entire
network. Copyright © 2005 Society for Neuroscience.
author:
- first_name: Thomas
full_name: Klausberger,Thomas
last_name: Klausberger
- first_name: Laszlo
full_name: Marton,Laszlo F
last_name: Marton
- first_name: Joseph
full_name: Joseph O'Neill
id: 426376DC-F248-11E8-B48F-1D18A9856A87
last_name: O'Neill
- first_name: Jojanneke
full_name: Huck, Jojanneke H
last_name: Huck
- first_name: Yannis
full_name: Dalezios, Yannis
last_name: Dalezios
- first_name: Pablo
full_name: Fuentealba,Pablo
last_name: Fuentealba
- first_name: Wai
full_name: Suen, Wai Yee
last_name: Suen
- first_name: Edit
full_name: Papp, Edit Cs
last_name: Papp
- first_name: Takeshi
full_name: Kaneko, Takeshi
last_name: Kaneko
- first_name: Masahiko
full_name: Watanabe, Masahiko
last_name: Watanabe
- first_name: Jozsef L
full_name: Jozsef Csicsvari
id: 3FA14672-F248-11E8-B48F-1D18A9856A87
last_name: Csicsvari
orcid: 0000-0002-5193-4036
- first_name: Péter
full_name: Somogyi, Péter
last_name: Somogyi
citation:
ama: Klausberger T, Marton L, O’Neill J, et al. Complementary roles of cholecystokinin-
and parvalbumin-expressing GABAergic neurons in hippocampal network oscillations.
Journal of Neuroscience. 2005;25(42):9782-9793. doi:10.1523/JNEUROSCI.3269-05.2005
apa: Klausberger, T., Marton, L., O’Neill, J., Huck, J., Dalezios, Y., Fuentealba,
P., … Somogyi, P. (2005). Complementary roles of cholecystokinin- and parvalbumin-expressing
GABAergic neurons in hippocampal network oscillations. Journal of Neuroscience.
Society for Neuroscience. https://doi.org/10.1523/JNEUROSCI.3269-05.2005
chicago: Klausberger, Thomas, Laszlo Marton, Joseph O’Neill, Jojanneke Huck, Yannis
Dalezios, Pablo Fuentealba, Wai Suen, et al. “Complementary Roles of Cholecystokinin-
and Parvalbumin-Expressing GABAergic Neurons in Hippocampal Network Oscillations.”
Journal of Neuroscience. Society for Neuroscience, 2005. https://doi.org/10.1523/JNEUROSCI.3269-05.2005.
ieee: T. Klausberger et al., “Complementary roles of cholecystokinin- and
parvalbumin-expressing GABAergic neurons in hippocampal network oscillations,”
Journal of Neuroscience, vol. 25, no. 42. Society for Neuroscience, pp.
9782–9793, 2005.
ista: Klausberger T, Marton L, O’Neill J, Huck J, Dalezios Y, Fuentealba P, Suen
W, Papp E, Kaneko T, Watanabe M, Csicsvari JL, Somogyi P. 2005. Complementary
roles of cholecystokinin- and parvalbumin-expressing GABAergic neurons in hippocampal
network oscillations. Journal of Neuroscience. 25(42), 9782–9793.
mla: Klausberger, Thomas, et al. “Complementary Roles of Cholecystokinin- and Parvalbumin-Expressing
GABAergic Neurons in Hippocampal Network Oscillations.” Journal of Neuroscience,
vol. 25, no. 42, Society for Neuroscience, 2005, pp. 9782–93, doi:10.1523/JNEUROSCI.3269-05.2005.
short: T. Klausberger, L. Marton, J. O’Neill, J. Huck, Y. Dalezios, P. Fuentealba,
W. Suen, E. Papp, T. Kaneko, M. Watanabe, J.L. Csicsvari, P. Somogyi, Journal
of Neuroscience 25 (2005) 9782–9793.
date_created: 2018-12-11T12:03:21Z
date_published: 2005-10-19T00:00:00Z
date_updated: 2021-01-12T07:43:30Z
day: '19'
doi: 10.1523/JNEUROSCI.3269-05.2005
extern: 1
intvolume: ' 25'
issue: '42'
month: '10'
page: 9782 - 9793
publication: Journal of Neuroscience
publication_status: published
publisher: Society for Neuroscience
publist_id: '2944'
quality_controlled: 0
status: public
title: Complementary roles of cholecystokinin- and parvalbumin-expressing GABAergic
neurons in hippocampal network oscillations
type: journal_article
volume: 25
year: '2005'
...