---
_id: '6194'
abstract:
- lang: eng
  text: Grid cells with their rigid hexagonal firing fields are thought to provide
    an invariant metric to the hippocampal cognitive map, yet environmental geometrical
    features have recently been shown to distort the grid structure. Given that the
    hippocampal role goes beyond space, we tested the influence of nonspatial information
    on the grid organization. We trained rats to daily learn three new reward locations
    on a cheeseboard maze while recording from the medial entorhinal cortex and the
    hippocampal CA1 region. Many grid fields moved toward goal location, leading to
    long-lasting deformations of the entorhinal map. Therefore, distortions in the
    grid structure contribute to goal representation during both learning and recall,
    which demonstrates that grid cells participate in mnemonic coding and do not merely
    provide a simple metric of space.
article_processing_charge: No
article_type: original
author:
- first_name: Charlotte N.
  full_name: Boccara, Charlotte N.
  id: 3FC06552-F248-11E8-B48F-1D18A9856A87
  last_name: Boccara
  orcid: 0000-0001-7237-5109
- first_name: Michele
  full_name: Nardin, Michele
  id: 30BD0376-F248-11E8-B48F-1D18A9856A87
  last_name: Nardin
  orcid: 0000-0001-8849-6570
- first_name: Federico
  full_name: Stella, Federico
  id: 39AF1E74-F248-11E8-B48F-1D18A9856A87
  last_name: Stella
  orcid: 0000-0001-9439-3148
- first_name: Joseph
  full_name: O'Neill, Joseph
  id: 426376DC-F248-11E8-B48F-1D18A9856A87
  last_name: O'Neill
- first_name: Jozsef L
  full_name: Csicsvari, Jozsef L
  id: 3FA14672-F248-11E8-B48F-1D18A9856A87
  last_name: Csicsvari
  orcid: 0000-0002-5193-4036
citation:
  ama: Boccara CN, Nardin M, Stella F, O’Neill J, Csicsvari JL. The entorhinal cognitive
    map is attracted to goals. <i>Science</i>. 2019;363(6434):1443-1447. doi:<a href="https://doi.org/10.1126/science.aav4837">10.1126/science.aav4837</a>
  apa: Boccara, C. N., Nardin, M., Stella, F., O’Neill, J., &#38; Csicsvari, J. L.
    (2019). The entorhinal cognitive map is attracted to goals. <i>Science</i>. American
    Association for the Advancement of Science. <a href="https://doi.org/10.1126/science.aav4837">https://doi.org/10.1126/science.aav4837</a>
  chicago: Boccara, Charlotte N., Michele Nardin, Federico Stella, Joseph O’Neill,
    and Jozsef L Csicsvari. “The Entorhinal Cognitive Map Is Attracted to Goals.”
    <i>Science</i>. American Association for the Advancement of Science, 2019. <a
    href="https://doi.org/10.1126/science.aav4837">https://doi.org/10.1126/science.aav4837</a>.
  ieee: C. N. Boccara, M. Nardin, F. Stella, J. O’Neill, and J. L. Csicsvari, “The
    entorhinal cognitive map is attracted to goals,” <i>Science</i>, vol. 363, no.
    6434. American Association for the Advancement of Science, pp. 1443–1447, 2019.
  ista: Boccara CN, Nardin M, Stella F, O’Neill J, Csicsvari JL. 2019. The entorhinal
    cognitive map is attracted to goals. Science. 363(6434), 1443–1447.
  mla: Boccara, Charlotte N., et al. “The Entorhinal Cognitive Map Is Attracted to
    Goals.” <i>Science</i>, vol. 363, no. 6434, American Association for the Advancement
    of Science, 2019, pp. 1443–47, doi:<a href="https://doi.org/10.1126/science.aav4837">10.1126/science.aav4837</a>.
  short: C.N. Boccara, M. Nardin, F. Stella, J. O’Neill, J.L. Csicsvari, Science 363
    (2019) 1443–1447.
date_created: 2019-04-04T08:39:30Z
date_published: 2019-03-29T00:00:00Z
date_updated: 2024-03-25T23:30:09Z
day: '29'
ddc:
- '570'
department:
- _id: JoCs
doi: 10.1126/science.aav4837
ec_funded: 1
external_id:
  isi:
  - '000462738000034'
file:
- access_level: open_access
  checksum: 5e6b16742cde10a560cfaf2130764da1
  content_type: application/pdf
  creator: dernst
  date_created: 2020-05-14T09:11:10Z
  date_updated: 2020-07-14T12:47:23Z
  file_id: '7826'
  file_name: 2019_Science_Boccara.pdf
  file_size: 9045923
  relation: main_file
file_date_updated: 2020-07-14T12:47:23Z
has_accepted_license: '1'
intvolume: '       363'
isi: 1
issue: '6434'
language:
- iso: eng
month: '03'
oa: 1
oa_version: Submitted Version
page: 1443-1447
project:
- _id: 257A4776-B435-11E9-9278-68D0E5697425
  call_identifier: FP7
  grant_number: '281511'
  name: Memory-related information processing in neuronal circuits of the hippocampus
    and entorhinal cortex
- _id: 2564DBCA-B435-11E9-9278-68D0E5697425
  call_identifier: H2020
  grant_number: '665385'
  name: International IST Doctoral Program
publication: Science
publication_identifier:
  eissn:
  - 1095-9203
  issn:
  - 0036-8075
publication_status: published
publisher: American Association for the Advancement of Science
quality_controlled: '1'
related_material:
  link:
  - description: News on IST Homepage
    relation: press_release
    url: https://ist.ac.at/en/news/grid-cells-create-treasure-map-in-rat-brain/
  record:
  - id: '6062'
    relation: popular_science
    status: public
  - id: '11932'
    relation: dissertation_contains
    status: public
scopus_import: '1'
status: public
title: The entorhinal cognitive map is attracted to goals
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 363
year: '2019'
...
---
_id: '1132'
abstract:
- lang: eng
  text: The hippocampus is thought to initiate systems-wide mnemonic processes through
    the reactivation of previously acquired spatial and episodic memory traces, which
    can recruit the entorhinal cortex as a first stage of memory redistribution to
    other brain areas. Hippocampal reactivation occurs during sharp wave-ripples,
    in which synchronous network firing encodes sequences of places.We investigated
    the coordination of this replay by recording assembly activity simultaneously
    in the CA1 region of the hippocampus and superficial layers of the medial entorhinal
    cortex. We found that entorhinal cell assemblies can replay trajectories independently
    of the hippocampus and sharp wave-ripples. This suggests that the hippocampus
    is not the sole initiator of spatial and episodic memory trace reactivation. Memory
    systems involved in these processes may include nonhierarchical, parallel components.
article_processing_charge: No
author:
- first_name: Joseph
  full_name: O'Neill, Joseph
  id: 426376DC-F248-11E8-B48F-1D18A9856A87
  last_name: O'Neill
- first_name: Charlotte
  full_name: Boccara, Charlotte
  id: 3FC06552-F248-11E8-B48F-1D18A9856A87
  last_name: Boccara
  orcid: 0000-0001-7237-5109
- first_name: Federico
  full_name: Stella, Federico
  id: 39AF1E74-F248-11E8-B48F-1D18A9856A87
  last_name: Stella
  orcid: 0000-0001-9439-3148
- first_name: Philipp
  full_name: Schönenberger, Philipp
  id: 3B9D816C-F248-11E8-B48F-1D18A9856A87
  last_name: Schönenberger
- first_name: Jozsef L
  full_name: Csicsvari, Jozsef L
  id: 3FA14672-F248-11E8-B48F-1D18A9856A87
  last_name: Csicsvari
  orcid: 0000-0002-5193-4036
citation:
  ama: O’Neill J, Boccara CN, Stella F, Schönenberger P, Csicsvari JL. Superficial
    layers of the medial entorhinal cortex replay independently of the hippocampus.
    <i>Science</i>. 2017;355(6321):184-188. doi:<a href="https://doi.org/10.1126/science.aag2787">10.1126/science.aag2787</a>
  apa: O’Neill, J., Boccara, C. N., Stella, F., Schönenberger, P., &#38; Csicsvari,
    J. L. (2017). Superficial layers of the medial entorhinal cortex replay independently
    of the hippocampus. <i>Science</i>. American Association for the Advancement of
    Science. <a href="https://doi.org/10.1126/science.aag2787">https://doi.org/10.1126/science.aag2787</a>
  chicago: O’Neill, Joseph, Charlotte N. Boccara, Federico Stella, Philipp Schönenberger,
    and Jozsef L Csicsvari. “Superficial Layers of the Medial Entorhinal Cortex Replay
    Independently of the Hippocampus.” <i>Science</i>. American Association for the
    Advancement of Science, 2017. <a href="https://doi.org/10.1126/science.aag2787">https://doi.org/10.1126/science.aag2787</a>.
  ieee: J. O’Neill, C. N. Boccara, F. Stella, P. Schönenberger, and J. L. Csicsvari,
    “Superficial layers of the medial entorhinal cortex replay independently of the
    hippocampus,” <i>Science</i>, vol. 355, no. 6321. American Association for the
    Advancement of Science, pp. 184–188, 2017.
  ista: O’Neill J, Boccara CN, Stella F, Schönenberger P, Csicsvari JL. 2017. Superficial
    layers of the medial entorhinal cortex replay independently of the hippocampus.
    Science. 355(6321), 184–188.
  mla: O’Neill, Joseph, et al. “Superficial Layers of the Medial Entorhinal Cortex
    Replay Independently of the Hippocampus.” <i>Science</i>, vol. 355, no. 6321,
    American Association for the Advancement of Science, 2017, pp. 184–88, doi:<a
    href="https://doi.org/10.1126/science.aag2787">10.1126/science.aag2787</a>.
  short: J. O’Neill, C.N. Boccara, F. Stella, P. Schönenberger, J.L. Csicsvari, Science
    355 (2017) 184–188.
date_created: 2018-12-11T11:50:19Z
date_published: 2017-01-13T00:00:00Z
date_updated: 2023-09-20T11:30:35Z
day: '13'
ddc:
- '571'
department:
- _id: JoCs
doi: 10.1126/science.aag2787
ec_funded: 1
external_id:
  isi:
  - '000391743700044'
file:
- access_level: open_access
  content_type: application/pdf
  creator: system
  date_created: 2018-12-12T10:10:22Z
  date_updated: 2018-12-12T10:10:22Z
  file_id: '4809'
  file_name: IST-2018-976-v1+1_2017Preprint_ONeill_Superficial_layers.pdf
  file_size: 3761201
  relation: main_file
file_date_updated: 2018-12-12T10:10:22Z
has_accepted_license: '1'
intvolume: '       355'
isi: 1
issue: '6321'
language:
- iso: eng
month: '01'
oa: 1
oa_version: Submitted Version
page: 184 - 188
project:
- _id: 257A4776-B435-11E9-9278-68D0E5697425
  call_identifier: FP7
  grant_number: '281511'
  name: Memory-related information processing in neuronal circuits of the hippocampus
    and entorhinal cortex
publication: Science
publication_identifier:
  issn:
  - '00368075'
publication_status: published
publisher: American Association for the Advancement of Science
publist_id: '6226'
pubrep_id: '976'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Superficial layers of the medial entorhinal cortex replay independently of
  the hippocampus
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 355
year: '2017'
...
---
_id: '514'
abstract:
- lang: eng
  text: 'Orientation in space is represented in specialized brain circuits. Persistent
    head direction signals are transmitted from anterior thalamus to the presubiculum,
    but the identity of the presubicular target neurons, their connectivity and function
    in local microcircuits are unknown. Here, we examine how thalamic afferents recruit
    presubicular principal neurons and Martinotti interneurons, and the ensuing synaptic
    interactions between these cells. Pyramidal neuron activation of Martinotti cells
    in superficial layers is strongly facilitating such that high-frequency head directional
    stimulation efficiently unmutes synaptic excitation. Martinotti-cell feedback
    plays a dual role: precisely timed spikes may not inhibit the firing of in-tune
    head direction cells, while exerting lateral inhibition. Autonomous attractor
    dynamics emerge from a modelled network implementing wiring motifs and timing
    sensitive synaptic interactions in the pyramidal - Martinotti-cell feedback loop.
    This inhibitory microcircuit is therefore tuned to refine and maintain head direction
    information in the presubiculum.'
article_number: '16032'
author:
- first_name: Jean
  full_name: Simonnet, Jean
  last_name: Simonnet
- first_name: Mérie
  full_name: Nassar, Mérie
  last_name: Nassar
- first_name: Federico
  full_name: Stella, Federico
  id: 39AF1E74-F248-11E8-B48F-1D18A9856A87
  last_name: Stella
  orcid: 0000-0001-9439-3148
- first_name: Ivan
  full_name: Cohen, Ivan
  last_name: Cohen
- first_name: Bertrand
  full_name: Mathon, Bertrand
  last_name: Mathon
- first_name: Charlotte
  full_name: Boccara, Charlotte
  id: 3FC06552-F248-11E8-B48F-1D18A9856A87
  last_name: Boccara
  orcid: 0000-0001-7237-5109
- first_name: Richard
  full_name: Miles, Richard
  last_name: Miles
- first_name: Desdemona
  full_name: Fricker, Desdemona
  last_name: Fricker
citation:
  ama: Simonnet J, Nassar M, Stella F, et al. Activity dependent feedback inhibition
    may maintain head direction signals in mouse presubiculum. <i>Nature Communications</i>.
    2017;8. doi:<a href="https://doi.org/10.1038/ncomms16032">10.1038/ncomms16032</a>
  apa: Simonnet, J., Nassar, M., Stella, F., Cohen, I., Mathon, B., Boccara, C. N.,
    … Fricker, D. (2017). Activity dependent feedback inhibition may maintain head
    direction signals in mouse presubiculum. <i>Nature Communications</i>. Nature
    Publishing Group. <a href="https://doi.org/10.1038/ncomms16032">https://doi.org/10.1038/ncomms16032</a>
  chicago: Simonnet, Jean, Mérie Nassar, Federico Stella, Ivan Cohen, Bertrand Mathon,
    Charlotte N. Boccara, Richard Miles, and Desdemona Fricker. “Activity Dependent
    Feedback Inhibition May Maintain Head Direction Signals in Mouse Presubiculum.”
    <i>Nature Communications</i>. Nature Publishing Group, 2017. <a href="https://doi.org/10.1038/ncomms16032">https://doi.org/10.1038/ncomms16032</a>.
  ieee: J. Simonnet <i>et al.</i>, “Activity dependent feedback inhibition may maintain
    head direction signals in mouse presubiculum,” <i>Nature Communications</i>, vol.
    8. Nature Publishing Group, 2017.
  ista: Simonnet J, Nassar M, Stella F, Cohen I, Mathon B, Boccara CN, Miles R, Fricker
    D. 2017. Activity dependent feedback inhibition may maintain head direction signals
    in mouse presubiculum. Nature Communications. 8, 16032.
  mla: Simonnet, Jean, et al. “Activity Dependent Feedback Inhibition May Maintain
    Head Direction Signals in Mouse Presubiculum.” <i>Nature Communications</i>, vol.
    8, 16032, Nature Publishing Group, 2017, doi:<a href="https://doi.org/10.1038/ncomms16032">10.1038/ncomms16032</a>.
  short: J. Simonnet, M. Nassar, F. Stella, I. Cohen, B. Mathon, C.N. Boccara, R.
    Miles, D. Fricker, Nature Communications 8 (2017).
date_created: 2018-12-11T11:46:54Z
date_published: 2017-07-01T00:00:00Z
date_updated: 2021-01-12T08:01:16Z
day: '01'
ddc:
- '571'
department:
- _id: JoCs
doi: 10.1038/ncomms16032
file:
- access_level: open_access
  checksum: 76d8a2b72a58e56adb410ec37dfa7eee
  content_type: application/pdf
  creator: system
  date_created: 2018-12-12T10:14:31Z
  date_updated: 2020-07-14T12:46:36Z
  file_id: '5083'
  file_name: IST-2018-937-v1+1_2017_Stella_Activity_dependent.pdf
  file_size: 2948357
  relation: main_file
file_date_updated: 2020-07-14T12:46:36Z
has_accepted_license: '1'
intvolume: '         8'
language:
- iso: eng
month: '07'
oa: 1
oa_version: Published Version
publication: Nature Communications
publication_identifier:
  issn:
  - '20411723'
publication_status: published
publisher: Nature Publishing Group
publist_id: '7305'
pubrep_id: '937'
quality_controlled: '1'
scopus_import: 1
status: public
title: Activity dependent feedback inhibition may maintain head direction signals
  in mouse presubiculum
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 8
year: '2017'
...
---
_id: '1874'
abstract:
- lang: eng
  text: 'The hippocampal region, comprising the hippocampal formation and the parahippocampal
    region, has been one of the most intensively studied parts of the brain for decades.
    Better understanding of its functional diversity and complexity has led to an
    increased demand for specificity in experimental procedures and manipulations.
    In view of the complex 3D structure of the hippocampal region, precisely positioned
    experimental approaches require a fine-grained architectural description that
    is available and readable to experimentalists lacking detailed anatomical experience.
    In this paper, we provide the first cyto- and chemoarchitectural description of
    the hippocampal formation and parahippocampal region in the rat at high resolution
    and in the three standard sectional planes: coronal, horizontal and sagittal.
    The atlas uses a series of adjacent sections stained for neurons and for a number
    of chemical marker substances, particularly parvalbumin and calbindin. All the
    borders defined in one plane have been cross-checked against their counterparts
    in the other two planes. The entire dataset will be made available as a web-based
    interactive application through the Rodent Brain WorkBench (http://www.rbwb.org)
    which, together with this paper, provides a unique atlas resource.'
author:
- first_name: Charlotte
  full_name: Boccara, Charlotte
  id: 3FC06552-F248-11E8-B48F-1D18A9856A87
  last_name: Boccara
  orcid: 0000-0001-7237-5109
- first_name: Lisa
  full_name: Kjønigsen, Lisa
  last_name: Kjønigsen
- first_name: Ingvild
  full_name: Hammer, Ingvild
  last_name: Hammer
- first_name: Jan
  full_name: Bjaalie, Jan
  last_name: Bjaalie
- first_name: Trygve
  full_name: Leergaard, Trygve
  last_name: Leergaard
- first_name: Menno
  full_name: Witter, Menno
  last_name: Witter
citation:
  ama: Boccara CN, Kjønigsen L, Hammer I, Bjaalie J, Leergaard T, Witter M. A three-plane
    architectonic atlas of the rat hippocampal region. <i>Hippocampus</i>. 2015;25(7):838-857.
    doi:<a href="https://doi.org/10.1002/hipo.22407">10.1002/hipo.22407</a>
  apa: Boccara, C. N., Kjønigsen, L., Hammer, I., Bjaalie, J., Leergaard, T., &#38;
    Witter, M. (2015). A three-plane architectonic atlas of the rat hippocampal region.
    <i>Hippocampus</i>. Wiley. <a href="https://doi.org/10.1002/hipo.22407">https://doi.org/10.1002/hipo.22407</a>
  chicago: Boccara, Charlotte N., Lisa Kjønigsen, Ingvild Hammer, Jan Bjaalie, Trygve
    Leergaard, and Menno Witter. “A Three-Plane Architectonic Atlas of the Rat Hippocampal
    Region.” <i>Hippocampus</i>. Wiley, 2015. <a href="https://doi.org/10.1002/hipo.22407">https://doi.org/10.1002/hipo.22407</a>.
  ieee: C. N. Boccara, L. Kjønigsen, I. Hammer, J. Bjaalie, T. Leergaard, and M. Witter,
    “A three-plane architectonic atlas of the rat hippocampal region,” <i>Hippocampus</i>,
    vol. 25, no. 7. Wiley, pp. 838–857, 2015.
  ista: Boccara CN, Kjønigsen L, Hammer I, Bjaalie J, Leergaard T, Witter M. 2015.
    A three-plane architectonic atlas of the rat hippocampal region. Hippocampus.
    25(7), 838–857.
  mla: Boccara, Charlotte N., et al. “A Three-Plane Architectonic Atlas of the Rat
    Hippocampal Region.” <i>Hippocampus</i>, vol. 25, no. 7, Wiley, 2015, pp. 838–57,
    doi:<a href="https://doi.org/10.1002/hipo.22407">10.1002/hipo.22407</a>.
  short: C.N. Boccara, L. Kjønigsen, I. Hammer, J. Bjaalie, T. Leergaard, M. Witter,
    Hippocampus 25 (2015) 838–857.
date_created: 2018-12-11T11:54:29Z
date_published: 2015-07-01T00:00:00Z
date_updated: 2021-01-12T06:53:46Z
day: '01'
department:
- _id: JoCs
doi: 10.1002/hipo.22407
intvolume: '        25'
issue: '7'
language:
- iso: eng
month: '07'
oa_version: None
page: 838 - 857
publication: Hippocampus
publication_status: published
publisher: Wiley
publist_id: '5222'
quality_controlled: '1'
scopus_import: 1
status: public
title: A three-plane architectonic atlas of the rat hippocampal region
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 25
year: '2015'
...