---
_id: '6658'
abstract:
- lang: eng
  text: 'New genes are a major source of novelties, and a disproportionate amount
    of them are known to show testis expression in later phases of male gametogenesis
    in different groups such as mammals and plants. Here, we propose that this enhanced
    expression is a consequence of haploid selection during the latter stages of male
    gametogenesis. Because emerging adaptive mutations will be fixed faster if their
    phenotypes are expressed by haploid rather than diploid genotypes, new genes with
    advantageous functions arising during this unique stage of development have a
    better chance to become fixed. To test this hypothesis, expression levels of genes
    of differing evolutionary age were examined at various stages of Drosophila spermatogenesis.
    We found, consistent with a model based on haploid selection, that new Drosophila
    genes are both expressed in later haploid phases of spermatogenesis and harbor
    a significant enrichment of adaptive mutations. Additionally, the observed overexpression
    of new genes in the latter phases of spermatogenesis was limited to the autosomes.
    Because all male cells exhibit hemizygous expression for X-linked genes (and therefore
    effectively haploid), there is no expectation that selection acting on late spermatogenesis
    will have a different effect on X-linked genes in comparison to initial diploid
    phases. Together, our proposed hypothesis and the analyzed data suggest that natural
    selection in haploid cells elucidates several aspects of the origin of new genes
    by explaining the general prevalence of their testis expression, and a parsimonious
    solution for new alleles to avoid being lost by genetic drift or pseudogenization. '
article_processing_charge: No
author:
- first_name: Julia
  full_name: Raices, Julia
  id: 3EE67F22-F248-11E8-B48F-1D18A9856A87
  last_name: Raices
- first_name: Paulo
  full_name: Otto, Paulo
  last_name: Otto
- first_name: Maria
  full_name: Vibranovski, Maria
  last_name: Vibranovski
citation:
  ama: Raices J, Otto P, Vibranovski M. Haploid selection drives new gene male germline
    expression. <i>Genome Research</i>. 2019;29(7):1115-1122. doi:<a href="https://doi.org/10.1101/gr.238824.118">10.1101/gr.238824.118</a>
  apa: Raices, J., Otto, P., &#38; Vibranovski, M. (2019). Haploid selection drives
    new gene male germline expression. <i>Genome Research</i>. CSH Press. <a href="https://doi.org/10.1101/gr.238824.118">https://doi.org/10.1101/gr.238824.118</a>
  chicago: Raices, Julia, Paulo Otto, and Maria Vibranovski. “Haploid Selection Drives
    New Gene Male Germline Expression.” <i>Genome Research</i>. CSH Press, 2019. <a
    href="https://doi.org/10.1101/gr.238824.118">https://doi.org/10.1101/gr.238824.118</a>.
  ieee: J. Raices, P. Otto, and M. Vibranovski, “Haploid selection drives new gene
    male germline expression,” <i>Genome Research</i>, vol. 29, no. 7. CSH Press,
    pp. 1115–1122, 2019.
  ista: Raices J, Otto P, Vibranovski M. 2019. Haploid selection drives new gene male
    germline expression. Genome Research. 29(7), 1115–1122.
  mla: Raices, Julia, et al. “Haploid Selection Drives New Gene Male Germline Expression.”
    <i>Genome Research</i>, vol. 29, no. 7, CSH Press, 2019, pp. 1115–22, doi:<a href="https://doi.org/10.1101/gr.238824.118">10.1101/gr.238824.118</a>.
  short: J. Raices, P. Otto, M. Vibranovski, Genome Research 29 (2019) 1115–1122.
date_created: 2019-07-21T21:59:15Z
date_published: 2019-07-01T00:00:00Z
date_updated: 2023-08-29T06:35:05Z
day: '01'
ddc:
- '576'
department:
- _id: BeVi
doi: 10.1101/gr.238824.118
external_id:
  isi:
  - '000473730600007'
file:
- access_level: open_access
  checksum: 4636f03a6750f90b88bf2bc3eb9d71ae
  content_type: application/pdf
  creator: apreinsp
  date_created: 2019-07-24T08:05:56Z
  date_updated: 2020-07-14T12:47:35Z
  file_id: '6670'
  file_name: 2019_GenomeResearch_Raices.pdf
  file_size: 2319022
  relation: main_file
file_date_updated: 2020-07-14T12:47:35Z
has_accepted_license: '1'
intvolume: '        29'
isi: 1
issue: '7'
language:
- iso: eng
month: '07'
oa: 1
oa_version: Published Version
page: 1115-1122
publication: Genome Research
publication_status: published
publisher: CSH Press
quality_controlled: '1'
scopus_import: '1'
status: public
title: Haploid selection drives new gene male germline expression
tmp:
  image: /images/cc_by_nc.png
  legal_code_url: https://creativecommons.org/licenses/by-nc/4.0/legalcode
  name: Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)
  short: CC BY-NC (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 29
year: '2019'
...