---
_id: '7472'
abstract:
- lang: eng
  text: Temporally organized reactivation of experiences during awake immobility periods
    is thought to underlie cognitive processes like planning and evaluation. While
    replay of trajectories is well established for the hippocampus, it is unclear
    whether the medial prefrontal cortex (mPFC) can reactivate sequential behavioral
    experiences in the awake state to support task execution. We simultaneously recorded
    from hippocampal and mPFC principal neurons in rats performing a mPFC-dependent
    rule-switching task on a plus maze. We found that mPFC neuronal activity encoded
    relative positions between the start and goal. During awake immobility periods,
    the mPFC replayed temporally organized sequences of these generalized positions,
    resembling entire spatial trajectories. The occurrence of mPFC trajectory replay
    positively correlated with rule-switching performance. However, hippocampal and
    mPFC trajectory replay occurred independently, indicating different functions.
    These results demonstrate that the mPFC can replay ordered activity patterns representing
    generalized locations and suggest that mPFC replay might have a role in flexible
    behavior.
acknowledged_ssus:
- _id: M-Shop
acknowledgement: We thank Todor Asenov and Thomas Menner from the Machine Shop for
  the drive design and production, Hugo Malagon-Vina for assistance in maze automatization,
  Jago Wallenschus for taking the images of the histology, and Federico Stella and
  Juan Felipe Ramirez-Villegas for comments on an earlier version of the manuscript.
  This work was supported by the EU-FP7 MC-ITN IN-SENS (grant 607616 ).
article_processing_charge: No
article_type: original
author:
- first_name: Karola
  full_name: Käfer, Karola
  id: 2DAA49AA-F248-11E8-B48F-1D18A9856A87
  last_name: Käfer
- first_name: Michele
  full_name: Nardin, Michele
  id: 30BD0376-F248-11E8-B48F-1D18A9856A87
  last_name: Nardin
  orcid: 0000-0001-8849-6570
- first_name: Karel
  full_name: Blahna, Karel
  id: 3EA859AE-F248-11E8-B48F-1D18A9856A87
  last_name: Blahna
- first_name: Jozsef L
  full_name: Csicsvari, Jozsef L
  id: 3FA14672-F248-11E8-B48F-1D18A9856A87
  last_name: Csicsvari
  orcid: 0000-0002-5193-4036
citation:
  ama: Käfer K, Nardin M, Blahna K, Csicsvari JL. Replay of behavioral sequences in
    the medial prefrontal cortex during rule switching. <i>Neuron</i>. 2020;106(1):P154-165.e6.
    doi:<a href="https://doi.org/10.1016/j.neuron.2020.01.015">10.1016/j.neuron.2020.01.015</a>
  apa: Käfer, K., Nardin, M., Blahna, K., &#38; Csicsvari, J. L. (2020). Replay of
    behavioral sequences in the medial prefrontal cortex during rule switching. <i>Neuron</i>.
    Elsevier. <a href="https://doi.org/10.1016/j.neuron.2020.01.015">https://doi.org/10.1016/j.neuron.2020.01.015</a>
  chicago: Käfer, Karola, Michele Nardin, Karel Blahna, and Jozsef L Csicsvari. “Replay
    of Behavioral Sequences in the Medial Prefrontal Cortex during Rule Switching.”
    <i>Neuron</i>. Elsevier, 2020. <a href="https://doi.org/10.1016/j.neuron.2020.01.015">https://doi.org/10.1016/j.neuron.2020.01.015</a>.
  ieee: K. Käfer, M. Nardin, K. Blahna, and J. L. Csicsvari, “Replay of behavioral
    sequences in the medial prefrontal cortex during rule switching,” <i>Neuron</i>,
    vol. 106, no. 1. Elsevier, p. P154–165.e6, 2020.
  ista: Käfer K, Nardin M, Blahna K, Csicsvari JL. 2020. Replay of behavioral sequences
    in the medial prefrontal cortex during rule switching. Neuron. 106(1), P154–165.e6.
  mla: Käfer, Karola, et al. “Replay of Behavioral Sequences in the Medial Prefrontal
    Cortex during Rule Switching.” <i>Neuron</i>, vol. 106, no. 1, Elsevier, 2020,
    p. P154–165.e6, doi:<a href="https://doi.org/10.1016/j.neuron.2020.01.015">10.1016/j.neuron.2020.01.015</a>.
  short: K. Käfer, M. Nardin, K. Blahna, J.L. Csicsvari, Neuron 106 (2020) P154–165.e6.
date_created: 2020-02-10T15:45:48Z
date_published: 2020-04-08T00:00:00Z
date_updated: 2023-08-17T14:38:02Z
day: '08'
department:
- _id: JoCs
doi: 10.1016/j.neuron.2020.01.015
ec_funded: 1
external_id:
  isi:
  - '000525319300016'
  pmid:
  - '32032512'
intvolume: '       106'
isi: 1
issue: '1'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://doi.org/10.1016/j.neuron.2020.01.015
month: '04'
oa: 1
oa_version: Published Version
page: P154-165.e6
pmid: 1
project:
- _id: 257BBB4C-B435-11E9-9278-68D0E5697425
  call_identifier: FP7
  grant_number: '607616'
  name: Inter-and intracellular signalling in schizophrenia
publication: Neuron
publication_identifier:
  issn:
  - 0896-6273
publication_status: published
publisher: Elsevier
quality_controlled: '1'
related_material:
  link:
  - description: News on IST Homepage
    relation: press_release
    url: https://ist.ac.at/en/news/this-brain-area-helps-us-decide/
scopus_import: '1'
status: public
title: Replay of behavioral sequences in the medial prefrontal cortex during rule
  switching
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 106
year: '2020'
...