---
_id: '2838'
abstract:
- lang: eng
  text: Individuals with Down syndrome (DS) present important motor deficits that
    derive from altered motor development of infants and young children. DYRK1A, a
    candidate gene for DS abnormalities has been implicated in motor function due
    to its expression in motor nuclei in the adult brain, and its overexpression in
    DS mouse models leads to hyperactivity and altered motor learning. However, its
    precise role in the adult motor system, or its possible involvement in postnatal
    locomotor development has not yet been clarified. During the postnatal period
    we observed time-specific expression of Dyrk1A in discrete subsets of brainstem
    nuclei and spinal cord motor neurons. Interestingly, we describe for the first
    time the presence of Dyrk1A in the presynaptic terminal of the neuromuscular junctions
    and its axonal transport from the facial nucleus, suggesting a function for Dyrk1A
    in these structures. Relevant to DS, Dyrk1A overexpression in transgenic mice
    (TgDyrk1A) produces motor developmental alterations possibly contributing to DS
    motor phenotypes and modifies the numbers of motor cholinergic neurons, suggesting
    that the kinase may have a role in the development of the brainstem and spinal
    cord motor system.
article_number: e54285
author:
- first_name: Gloria
  full_name: Arquè Fuste, Gloria
  id: 3CF33908-F248-11E8-B48F-1D18A9856A87
  last_name: Arquè Fuste
- first_name: Anna
  full_name: Casanovas, Anna
  last_name: Casanovas
- first_name: Mara
  full_name: Dierssen, Mara
  last_name: Dierssen
citation:
  ama: 'Arquè Fuste G, Casanovas A, Dierssen M. Dyrk1A is dynamically expressed on
    subsets of motor neurons and in the neuromuscular junction: Possible role in Down
    syndrome. <i>PLoS One</i>. 2013;8(1). doi:<a href="https://doi.org/10.1371/journal.pone.0054285">10.1371/journal.pone.0054285</a>'
  apa: 'Arquè Fuste, G., Casanovas, A., &#38; Dierssen, M. (2013). Dyrk1A is dynamically
    expressed on subsets of motor neurons and in the neuromuscular junction: Possible
    role in Down syndrome. <i>PLoS One</i>. Public Library of Science. <a href="https://doi.org/10.1371/journal.pone.0054285">https://doi.org/10.1371/journal.pone.0054285</a>'
  chicago: 'Arquè Fuste, Gloria, Anna Casanovas, and Mara Dierssen. “Dyrk1A Is Dynamically
    Expressed on Subsets of Motor Neurons and in the Neuromuscular Junction: Possible
    Role in Down Syndrome.” <i>PLoS One</i>. Public Library of Science, 2013. <a href="https://doi.org/10.1371/journal.pone.0054285">https://doi.org/10.1371/journal.pone.0054285</a>.'
  ieee: 'G. Arquè Fuste, A. Casanovas, and M. Dierssen, “Dyrk1A is dynamically expressed
    on subsets of motor neurons and in the neuromuscular junction: Possible role in
    Down syndrome,” <i>PLoS One</i>, vol. 8, no. 1. Public Library of Science, 2013.'
  ista: 'Arquè Fuste G, Casanovas A, Dierssen M. 2013. Dyrk1A is dynamically expressed
    on subsets of motor neurons and in the neuromuscular junction: Possible role in
    Down syndrome. PLoS One. 8(1), e54285.'
  mla: 'Arquè Fuste, Gloria, et al. “Dyrk1A Is Dynamically Expressed on Subsets of
    Motor Neurons and in the Neuromuscular Junction: Possible Role in Down Syndrome.”
    <i>PLoS One</i>, vol. 8, no. 1, e54285, Public Library of Science, 2013, doi:<a
    href="https://doi.org/10.1371/journal.pone.0054285">10.1371/journal.pone.0054285</a>.'
  short: G. Arquè Fuste, A. Casanovas, M. Dierssen, PLoS One 8 (2013).
date_created: 2018-12-11T11:59:52Z
date_published: 2013-01-16T00:00:00Z
date_updated: 2021-01-12T07:00:07Z
day: '16'
ddc:
- '570'
department:
- _id: SiHi
doi: 10.1371/journal.pone.0054285
file:
- access_level: open_access
  checksum: 512733b21419574a45f10cabef3d7f81
  content_type: application/pdf
  creator: system
  date_created: 2018-12-12T10:15:38Z
  date_updated: 2020-07-14T12:45:50Z
  file_id: '5160'
  file_name: IST-2016-407-v1+1_journal.pone.0054285.pdf
  file_size: 4795977
  relation: main_file
file_date_updated: 2020-07-14T12:45:50Z
has_accepted_license: '1'
intvolume: '         8'
issue: '1'
language:
- iso: eng
month: '01'
oa: 1
oa_version: Published Version
publication: PLoS One
publication_status: published
publisher: Public Library of Science
publist_id: '3960'
pubrep_id: '407'
quality_controlled: '1'
scopus_import: 1
status: public
title: 'Dyrk1A is dynamically expressed on subsets of motor neurons and in the neuromuscular
  junction: Possible role in Down syndrome'
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 3E5EF7F0-F248-11E8-B48F-1D18A9856A87
volume: 8
year: '2013'
...