---
_id: '10896'
abstract:
- lang: eng
  text: Under physiological conditions the brain, via the purine salvage pathway,
    reuses the preformed purine bases hypoxanthine, derived from ATP degradation,
    and adenine (Ade), derived from polyamine synthesis, to restore its ATP pool.
    However, the massive degradation of ATP during ischemia, although providing valuable
    neuroprotective adenosine, results in the accumulation and loss of diffusible
    purine metabolites and thereby leads to a protracted reduction in the post-ischemic
    ATP pool size. In vivo, this may both limit the ability to deploy ATP-dependent
    reparative mechanisms and reduce the subsequent availability of adenosine, whilst
    in brain slices results in tissue with substantially lower levels of ATP than
    in vivo. In the present review, we describe the mechanisms by which brain tissue
    replenishes its ATP, how this can be improved with the clinically tolerated chemicals
    D-ribose and adenine, and the functional, and potential therapeutic, implications
    of doing so.
acknowledgement: We are grateful to Research into Ageing/Ageing UK and The Dunhill
  Trust for funding SzN’s graduate studies, and to Prof Nicholas Dale for his valuable
  input.
article_processing_charge: No
author:
- first_name: Stephanie
  full_name: zur Nedden, Stephanie
  id: 3C77F464-F248-11E8-B48F-1D18A9856A87
  last_name: zur Nedden
- first_name: Alexander S.
  full_name: Doney, Alexander S.
  last_name: Doney
- first_name: Bruno G.
  full_name: Frenguelli, Bruno G.
  last_name: Frenguelli
citation:
  ama: 'zur Nedden S, Doney AS, Frenguelli BG. The double-edged sword: Gaining Adenosine
    at the expense of ATP. How to balance the books. In: Masino S, Boison D, eds.
    <i>Adenosine</i>. 1st ed. New York: Springer; 2012:109-129. doi:<a href="https://doi.org/10.1007/978-1-4614-3903-5_6">10.1007/978-1-4614-3903-5_6</a>'
  apa: 'zur Nedden, S., Doney, A. S., &#38; Frenguelli, B. G. (2012). The double-edged
    sword: Gaining Adenosine at the expense of ATP. How to balance the books. In S.
    Masino &#38; D. Boison (Eds.), <i>Adenosine</i> (1st ed., pp. 109–129). New York:
    Springer. <a href="https://doi.org/10.1007/978-1-4614-3903-5_6">https://doi.org/10.1007/978-1-4614-3903-5_6</a>'
  chicago: 'Nedden, Stephanie zur, Alexander S. Doney, and Bruno G. Frenguelli. “The
    Double-Edged Sword: Gaining Adenosine at the Expense of ATP. How to Balance the
    Books.” In <i>Adenosine</i>, edited by Susan Masino and Detlev Boison, 1st ed.,
    109–29. New York: Springer, 2012. <a href="https://doi.org/10.1007/978-1-4614-3903-5_6">https://doi.org/10.1007/978-1-4614-3903-5_6</a>.'
  ieee: 'S. zur Nedden, A. S. Doney, and B. G. Frenguelli, “The double-edged sword:
    Gaining Adenosine at the expense of ATP. How to balance the books,” in <i>Adenosine</i>,
    1st ed., S. Masino and D. Boison, Eds. New York: Springer, 2012, pp. 109–129.'
  ista: 'zur Nedden S, Doney AS, Frenguelli BG. 2012.The double-edged sword: Gaining
    Adenosine at the expense of ATP. How to balance the books. In: Adenosine. , 109–129.'
  mla: 'zur Nedden, Stephanie, et al. “The Double-Edged Sword: Gaining Adenosine at
    the Expense of ATP. How to Balance the Books.” <i>Adenosine</i>, edited by Susan
    Masino and Detlev Boison, 1st ed., Springer, 2012, pp. 109–29, doi:<a href="https://doi.org/10.1007/978-1-4614-3903-5_6">10.1007/978-1-4614-3903-5_6</a>.'
  short: S. zur Nedden, A.S. Doney, B.G. Frenguelli, in:, S. Masino, D. Boison (Eds.),
    Adenosine, 1st ed., Springer, New York, 2012, pp. 109–129.
date_created: 2022-03-21T07:16:12Z
date_published: 2012-07-23T00:00:00Z
date_updated: 2022-06-21T11:51:58Z
day: '23'
department:
- _id: HaJa
doi: 10.1007/978-1-4614-3903-5_6
edition: '1'
editor:
- first_name: Susan
  full_name: Masino, Susan
  last_name: Masino
- first_name: Detlev
  full_name: Boison, Detlev
  last_name: Boison
language:
- iso: eng
month: '07'
oa_version: None
page: 109-129
place: New York
publication: Adenosine
publication_identifier:
  eisbn:
  - '9781461439035'
  isbn:
  - '9781461439028'
publication_status: published
publisher: Springer
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'The double-edged sword: Gaining Adenosine at the expense of ATP. How to balance
  the books'
type: book_chapter
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2012'
...