[{"citation":{"chicago":"Csicsvari, Jozsef L, Igor Gridchyn, and Philipp Schönenberger. “Optogenetic Alteration of Hippocampal Network Activity.” Institute of Science and Technology Austria, 2020. <a href=\"https://doi.org/10.15479/AT:ISTA:8563\">https://doi.org/10.15479/AT:ISTA:8563</a>.","ista":"Csicsvari JL, Gridchyn I, Schönenberger P. 2020. Optogenetic alteration of hippocampal network activity, Institute of Science and Technology Austria, <a href=\"https://doi.org/10.15479/AT:ISTA:8563\">10.15479/AT:ISTA:8563</a>.","apa":"Csicsvari, J. L., Gridchyn, I., &#38; Schönenberger, P. (2020). Optogenetic alteration of hippocampal network activity. Institute of Science and Technology Austria. <a href=\"https://doi.org/10.15479/AT:ISTA:8563\">https://doi.org/10.15479/AT:ISTA:8563</a>","mla":"Csicsvari, Jozsef L., et al. <i>Optogenetic Alteration of Hippocampal Network Activity</i>. Institute of Science and Technology Austria, 2020, doi:<a href=\"https://doi.org/10.15479/AT:ISTA:8563\">10.15479/AT:ISTA:8563</a>.","ama":"Csicsvari JL, Gridchyn I, Schönenberger P. Optogenetic alteration of hippocampal network activity. 2020. doi:<a href=\"https://doi.org/10.15479/AT:ISTA:8563\">10.15479/AT:ISTA:8563</a>","ieee":"J. L. Csicsvari, I. Gridchyn, and P. Schönenberger, “Optogenetic alteration of hippocampal network activity.” Institute of Science and Technology Austria, 2020.","short":"J.L. Csicsvari, I. Gridchyn, P. Schönenberger, (2020)."},"related_material":{"record":[{"id":"8740","relation":"used_in_publication","status":"public"}]},"file_date_updated":"2020-10-19T10:12:29Z","article_processing_charge":"No","ddc":["570"],"oa_version":"Published Version","type":"research_data","date_published":"2020-10-19T00:00:00Z","department":[{"_id":"JoCs"}],"has_accepted_license":"1","doi":"10.15479/AT:ISTA:8563","date_created":"2020-09-23T14:39:54Z","month":"10","contributor":[{"contributor_type":"project_leader","id":"3FA14672-F248-11E8-B48F-1D18A9856A87","last_name":"Csicsvari","first_name":"Jozsef L","orcid":"0000-0002-5193-4036"}],"publisher":"Institute of Science and Technology Austria","status":"public","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","title":"Optogenetic alteration of hippocampal network activity","oa":1,"author":[{"orcid":"0000-0002-5193-4036","first_name":"Jozsef L","id":"3FA14672-F248-11E8-B48F-1D18A9856A87","last_name":"Csicsvari","full_name":"Csicsvari, Jozsef L"},{"full_name":"Gridchyn, Igor","first_name":"Igor","orcid":"0000-0002-1807-1929","last_name":"Gridchyn","id":"4B60654C-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Schönenberger, Philipp","id":"3B9D816C-F248-11E8-B48F-1D18A9856A87","last_name":"Schönenberger","first_name":"Philipp"}],"file":[{"success":1,"file_size":145243906,"relation":"main_file","content_type":"application/x-compressed","access_level":"open_access","creator":"jozsef","file_id":"8564","checksum":"a16098a6d172f9c42ab5af5f6991668c","date_created":"2020-09-23T14:36:17Z","file_name":"upload.tgz","date_updated":"2020-09-23T14:36:17Z"},{"date_created":"2020-10-19T10:12:29Z","date_updated":"2020-10-19T10:12:29Z","file_name":"redme.docx","access_level":"open_access","creator":"jozsef","file_id":"8675","checksum":"0bfc54b7e14c0694cd081617318ba606","file_size":11648,"success":1,"content_type":"application/vnd.openxmlformats-officedocument.wordprocessingml.document","relation":"main_file"}],"_id":"8563","date_updated":"2024-02-21T12:43:41Z","abstract":[{"lang":"eng","text":"Supplementary data  provided for the provided for the publication:\r\nIgor Gridchyn , Philipp Schoenenberger , Joseph O'Neill , Jozsef Csicsvari (2020) Optogenetic inhibition-mediated activity-dependent modification of CA1 pyramidal-interneuron connections during behavior. Elife."}],"tmp":{"name":"Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)","legal_code_url":"https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode","short":"CC BY-NC-ND (4.0)","image":"/images/cc_by_nc_nd.png"},"day":"19","year":"2020"},{"_id":"8740","article_number":"61106","year":"2020","date_updated":"2024-02-21T12:43:40Z","abstract":[{"text":"In vitro work revealed that excitatory synaptic inputs to hippocampal inhibitory interneurons could undergo Hebbian, associative, or non-associative plasticity. Both behavioral and learning-dependent reorganization of these connections has also been demonstrated by measuring spike transmission probabilities in pyramidal cell-interneuron spike cross-correlations that indicate monosynaptic connections. Here we investigated the activity-dependent modification of these connections during exploratory behavior in rats by optogenetically inhibiting pyramidal cell and interneuron subpopulations. Light application and associated firing alteration of pyramidal and interneuron populations led to lasting changes in pyramidal-interneuron connection weights as indicated by spike transmission changes. Spike transmission alterations were predicted by the light-mediated changes in the number of pre- and postsynaptic spike pairing events and by firing rate changes of interneurons but not pyramidal cells. This work demonstrates the presence of activity-dependent associative and non-associative reorganization of pyramidal-interneuron connections triggered by the optogenetic modification of the firing rate and spike synchrony of cells.","lang":"eng"}],"month":"10","oa":1,"publication_identifier":{"eissn":["2050084X"]},"status":"public","date_published":"2020-10-05T00:00:00Z","oa_version":"Published Version","publication_status":"published","doi":"10.7554/eLife.61106","citation":{"short":"I. Gridchyn, P. Schönenberger, J. O’Neill, J.L. Csicsvari, ELife 9 (2020).","ieee":"I. Gridchyn, P. Schönenberger, J. O’Neill, and J. L. Csicsvari, “Optogenetic inhibition-mediated activity-dependent modification of CA1 pyramidal-interneuron connections during behavior,” <i>eLife</i>, vol. 9. eLife Sciences Publications, 2020.","ama":"Gridchyn I, Schönenberger P, O’Neill J, Csicsvari JL. Optogenetic inhibition-mediated activity-dependent modification of CA1 pyramidal-interneuron connections during behavior. <i>eLife</i>. 2020;9. doi:<a href=\"https://doi.org/10.7554/eLife.61106\">10.7554/eLife.61106</a>","chicago":"Gridchyn, Igor, Philipp Schönenberger, Joseph O’Neill, and Jozsef L Csicsvari. “Optogenetic Inhibition-Mediated Activity-Dependent Modification of CA1 Pyramidal-Interneuron Connections during Behavior.” <i>ELife</i>. eLife Sciences Publications, 2020. <a href=\"https://doi.org/10.7554/eLife.61106\">https://doi.org/10.7554/eLife.61106</a>.","apa":"Gridchyn, I., Schönenberger, P., O’Neill, J., &#38; Csicsvari, J. L. (2020). Optogenetic inhibition-mediated activity-dependent modification of CA1 pyramidal-interneuron connections during behavior. <i>ELife</i>. eLife Sciences Publications. <a href=\"https://doi.org/10.7554/eLife.61106\">https://doi.org/10.7554/eLife.61106</a>","mla":"Gridchyn, Igor, et al. “Optogenetic Inhibition-Mediated Activity-Dependent Modification of CA1 Pyramidal-Interneuron Connections during Behavior.” <i>ELife</i>, vol. 9, 61106, eLife Sciences Publications, 2020, doi:<a href=\"https://doi.org/10.7554/eLife.61106\">10.7554/eLife.61106</a>.","ista":"Gridchyn I, Schönenberger P, O’Neill J, Csicsvari JL. 2020. Optogenetic inhibition-mediated activity-dependent modification of CA1 pyramidal-interneuron connections during behavior. eLife. 9, 61106."},"intvolume":"         9","ddc":["570"],"scopus_import":"1","file_date_updated":"2020-11-09T09:17:40Z","file":[{"relation":"main_file","content_type":"application/pdf","success":1,"file_size":447669,"date_updated":"2020-11-09T09:17:40Z","file_name":"2020_eLife_Gridchyn.pdf","date_created":"2020-11-09T09:17:40Z","creator":"dernst","file_id":"8749","checksum":"6a7b0543c440f4c000a1864e69377d95","access_level":"open_access"}],"project":[{"grant_number":"I2072-B27","_id":"257D4372-B435-11E9-9278-68D0E5697425","call_identifier":"FWF","name":"Interneuron plasticity during spatial learning"},{"_id":"2654F984-B435-11E9-9278-68D0E5697425","grant_number":"I03713","name":"Interneuro Plasticity During Spatial Learning","call_identifier":"FWF"}],"isi":1,"author":[{"orcid":"0000-0002-1807-1929","first_name":"Igor","id":"4B60654C-F248-11E8-B48F-1D18A9856A87","last_name":"Gridchyn","full_name":"Gridchyn, Igor"},{"first_name":"Philipp","id":"3B9D816C-F248-11E8-B48F-1D18A9856A87","last_name":"Schönenberger","full_name":"Schönenberger, Philipp"},{"id":"426376DC-F248-11E8-B48F-1D18A9856A87","last_name":"O'Neill","first_name":"Joseph","full_name":"O'Neill, Joseph"},{"full_name":"Csicsvari, Jozsef L","orcid":"0000-0002-5193-4036","first_name":"Jozsef L","last_name":"Csicsvari","id":"3FA14672-F248-11E8-B48F-1D18A9856A87"}],"tmp":{"short":"CC BY (4.0)","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"day":"05","acknowledgement":"We thank Michele Nardin and Federico Stella for comments on an earlier version of the manuscript. K Deisseroth for providing the pAAV-CaMKIIα::eNpHR3.0-YFP plasmid through Addgene. E Boyden for providing AAV2/1.CaMKII::ArchT.GFP.WPRE.SV40 plasmid through Penn Vector Core. This work was supported by the Austrian Science Fund (I02072 and I03713) and a Swiss National Science Foundation grant to PS. The authors declare no conflicts of interest.","title":"Optogenetic inhibition-mediated activity-dependent modification of CA1 pyramidal-interneuron connections during behavior","publisher":"eLife Sciences Publications","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","language":[{"iso":"eng"}],"department":[{"_id":"JoCs"}],"type":"journal_article","date_created":"2020-11-08T23:01:25Z","publication":"eLife","has_accepted_license":"1","related_material":{"record":[{"id":"8563","status":"public","relation":"research_data"}]},"external_id":{"isi":["000584369000001"]},"volume":9,"quality_controlled":"1","article_processing_charge":"No","article_type":"original"},{"article_processing_charge":"No","article_type":"original","volume":106,"quality_controlled":"1","external_id":{"pmid":["32070475"],"isi":["000528268200013"]},"related_material":{"link":[{"url":"https://ist.ac.at/en/news/librarian-of-memory/","description":"News on IST Homepage","relation":"press_release"}]},"publication":"Neuron","date_created":"2020-04-26T22:00:45Z","page":"291-300.e6","type":"journal_article","department":[{"_id":"JoCs"}],"language":[{"iso":"eng"}],"user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","publisher":"Elsevier","title":"Assembly-specific disruption of hippocampal replay leads to selective memory deficit","pmid":1,"day":"22","author":[{"full_name":"Gridchyn, Igor","last_name":"Gridchyn","id":"4B60654C-F248-11E8-B48F-1D18A9856A87","first_name":"Igor","orcid":"0000-0002-1807-1929"},{"full_name":"Schönenberger, Philipp","first_name":"Philipp","id":"3B9D816C-F248-11E8-B48F-1D18A9856A87","last_name":"Schönenberger"},{"full_name":"O'Neill, Joseph","first_name":"Joseph","last_name":"O'Neill","id":"426376DC-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Csicsvari, Jozsef L","id":"3FA14672-F248-11E8-B48F-1D18A9856A87","last_name":"Csicsvari","orcid":"0000-0002-5193-4036","first_name":"Jozsef L"}],"isi":1,"project":[{"_id":"257A4776-B435-11E9-9278-68D0E5697425","grant_number":"281511","name":"Memory-related information processing in neuronal circuits of the hippocampus and entorhinal cortex","call_identifier":"FP7"}],"main_file_link":[{"open_access":"1","url":"https://doi.org/10.1016/j.neuron.2020.01.021"}],"scopus_import":"1","citation":{"ista":"Gridchyn I, Schönenberger P, O’Neill J, Csicsvari JL. 2020. Assembly-specific disruption of hippocampal replay leads to selective memory deficit. Neuron. 106(2), 291–300.e6.","apa":"Gridchyn, I., Schönenberger, P., O’Neill, J., &#38; Csicsvari, J. L. (2020). Assembly-specific disruption of hippocampal replay leads to selective memory deficit. <i>Neuron</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.neuron.2020.01.021\">https://doi.org/10.1016/j.neuron.2020.01.021</a>","mla":"Gridchyn, Igor, et al. “Assembly-Specific Disruption of Hippocampal Replay Leads to Selective Memory Deficit.” <i>Neuron</i>, vol. 106, no. 2, Elsevier, 2020, p. 291–300.e6, doi:<a href=\"https://doi.org/10.1016/j.neuron.2020.01.021\">10.1016/j.neuron.2020.01.021</a>.","chicago":"Gridchyn, Igor, Philipp Schönenberger, Joseph O’Neill, and Jozsef L Csicsvari. “Assembly-Specific Disruption of Hippocampal Replay Leads to Selective Memory Deficit.” <i>Neuron</i>. Elsevier, 2020. <a href=\"https://doi.org/10.1016/j.neuron.2020.01.021\">https://doi.org/10.1016/j.neuron.2020.01.021</a>.","ama":"Gridchyn I, Schönenberger P, O’Neill J, Csicsvari JL. Assembly-specific disruption of hippocampal replay leads to selective memory deficit. <i>Neuron</i>. 2020;106(2):291-300.e6. doi:<a href=\"https://doi.org/10.1016/j.neuron.2020.01.021\">10.1016/j.neuron.2020.01.021</a>","ieee":"I. Gridchyn, P. Schönenberger, J. O’Neill, and J. L. Csicsvari, “Assembly-specific disruption of hippocampal replay leads to selective memory deficit,” <i>Neuron</i>, vol. 106, no. 2. Elsevier, p. 291–300.e6, 2020.","short":"I. Gridchyn, P. Schönenberger, J. O’Neill, J.L. Csicsvari, Neuron 106 (2020) 291–300.e6."},"intvolume":"       106","doi":"10.1016/j.neuron.2020.01.021","publication_status":"published","oa_version":"Published Version","date_published":"2020-04-22T00:00:00Z","status":"public","publication_identifier":{"issn":["08966273"],"eissn":["10974199"]},"oa":1,"month":"04","ec_funded":1,"issue":"2","date_updated":"2023-08-21T06:15:31Z","year":"2020","_id":"7684"},{"ec_funded":1,"month":"01","publication_identifier":{"issn":["00368075"]},"oa":1,"status":"public","_id":"1132","year":"2017","date_updated":"2023-09-20T11:30:35Z","issue":"6321","abstract":[{"lang":"eng","text":"The hippocampus is thought to initiate systems-wide mnemonic processes through the reactivation of previously acquired spatial and episodic memory traces, which can recruit the entorhinal cortex as a first stage of memory redistribution to other brain areas. Hippocampal reactivation occurs during sharp wave-ripples, in which synchronous network firing encodes sequences of places.We investigated the coordination of this replay by recording assembly activity simultaneously in the CA1 region of the hippocampus and superficial layers of the medial entorhinal cortex. We found that entorhinal cell assemblies can replay trajectories independently of the hippocampus and sharp wave-ripples. This suggests that the hippocampus is not the sole initiator of spatial and episodic memory trace reactivation. Memory systems involved in these processes may include nonhierarchical, parallel components."}],"citation":{"short":"J. O’Neill, C.N. Boccara, F. Stella, P. Schönenberger, J.L. Csicsvari, Science 355 (2017) 184–188.","ama":"O’Neill J, Boccara CN, Stella F, Schönenberger P, Csicsvari JL. Superficial layers of the medial entorhinal cortex replay independently of the hippocampus. <i>Science</i>. 2017;355(6321):184-188. doi:<a href=\"https://doi.org/10.1126/science.aag2787\">10.1126/science.aag2787</a>","ieee":"J. O’Neill, C. N. Boccara, F. Stella, P. Schönenberger, and J. L. Csicsvari, “Superficial layers of the medial entorhinal cortex replay independently of the hippocampus,” <i>Science</i>, vol. 355, no. 6321. American Association for the Advancement of Science, pp. 184–188, 2017.","apa":"O’Neill, J., Boccara, C. N., Stella, F., Schönenberger, P., &#38; Csicsvari, J. L. (2017). Superficial layers of the medial entorhinal cortex replay independently of the hippocampus. <i>Science</i>. American Association for the Advancement of Science. <a href=\"https://doi.org/10.1126/science.aag2787\">https://doi.org/10.1126/science.aag2787</a>","ista":"O’Neill J, Boccara CN, Stella F, Schönenberger P, Csicsvari JL. 2017. Superficial layers of the medial entorhinal cortex replay independently of the hippocampus. Science. 355(6321), 184–188.","mla":"O’Neill, Joseph, et al. “Superficial Layers of the Medial Entorhinal Cortex Replay Independently of the Hippocampus.” <i>Science</i>, vol. 355, no. 6321, American Association for the Advancement of Science, 2017, pp. 184–88, doi:<a href=\"https://doi.org/10.1126/science.aag2787\">10.1126/science.aag2787</a>.","chicago":"O’Neill, Joseph, Charlotte N. Boccara, Federico Stella, Philipp Schönenberger, and Jozsef L Csicsvari. “Superficial Layers of the Medial Entorhinal Cortex Replay Independently of the Hippocampus.” <i>Science</i>. American Association for the Advancement of Science, 2017. <a href=\"https://doi.org/10.1126/science.aag2787\">https://doi.org/10.1126/science.aag2787</a>."},"intvolume":"       355","ddc":["571"],"file_date_updated":"2018-12-12T10:10:22Z","scopus_import":"1","date_published":"2017-01-13T00:00:00Z","oa_version":"Submitted Version","publication_status":"published","doi":"10.1126/science.aag2787","title":"Superficial layers of the medial entorhinal cortex replay independently of the hippocampus","publisher":"American Association for the Advancement of Science","user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1","file":[{"relation":"main_file","content_type":"application/pdf","file_size":3761201,"date_updated":"2018-12-12T10:10:22Z","file_name":"IST-2018-976-v1+1_2017Preprint_ONeill_Superficial_layers.pdf","date_created":"2018-12-12T10:10:22Z","creator":"system","file_id":"4809","access_level":"open_access"}],"project":[{"_id":"257A4776-B435-11E9-9278-68D0E5697425","grant_number":"281511","call_identifier":"FP7","name":"Memory-related information processing in neuronal circuits of the hippocampus and entorhinal cortex"}],"isi":1,"author":[{"full_name":"O'Neill, Joseph","id":"426376DC-F248-11E8-B48F-1D18A9856A87","last_name":"O'Neill","first_name":"Joseph"},{"full_name":"Boccara, Charlotte","id":"3FC06552-F248-11E8-B48F-1D18A9856A87","last_name":"Boccara","first_name":"Charlotte","orcid":"0000-0001-7237-5109"},{"full_name":"Stella, Federico","last_name":"Stella","id":"39AF1E74-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-9439-3148","first_name":"Federico"},{"last_name":"Schönenberger","id":"3B9D816C-F248-11E8-B48F-1D18A9856A87","first_name":"Philipp","full_name":"Schönenberger, Philipp"},{"full_name":"Csicsvari, Jozsef L","first_name":"Jozsef L","orcid":"0000-0002-5193-4036","last_name":"Csicsvari","id":"3FA14672-F248-11E8-B48F-1D18A9856A87"}],"day":"13","external_id":{"isi":["000391743700044"]},"volume":355,"quality_controlled":"1","publist_id":"6226","article_processing_charge":"No","pubrep_id":"976","language":[{"iso":"eng"}],"department":[{"_id":"JoCs"}],"type":"journal_article","page":"184 - 188","date_created":"2018-12-11T11:50:19Z","publication":"Science","has_accepted_license":"1"},{"day":"10","tmp":{"short":"CC BY (4.0)","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"author":[{"last_name":"Schönenberger","id":"3B9D816C-F248-11E8-B48F-1D18A9856A87","first_name":"Philipp","full_name":"Schönenberger, Philipp"},{"id":"426376DC-F248-11E8-B48F-1D18A9856A87","last_name":"O'Neill","first_name":"Joseph","full_name":"O'Neill, Joseph"},{"last_name":"Csicsvari","id":"3FA14672-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-5193-4036","first_name":"Jozsef L","full_name":"Csicsvari, Jozsef L"}],"project":[{"call_identifier":"FP7","name":"Memory-related information processing in neuronal circuits of the hippocampus and entorhinal cortex","_id":"257A4776-B435-11E9-9278-68D0E5697425","grant_number":"281511"},{"name":"Interneuron plasticity during spatial learning","call_identifier":"FWF","grant_number":"I2072-B27","_id":"257D4372-B435-11E9-9278-68D0E5697425"}],"file":[{"file_name":"IST-2016-660-v1+1_ncomms11824.pdf","date_updated":"2020-07-14T12:44:44Z","date_created":"2018-12-12T10:16:10Z","creator":"system","file_id":"5196","checksum":"e43307754abe65b840a21939fe163618","access_level":"open_access","relation":"main_file","content_type":"application/pdf","file_size":1793846}],"user_id":"3E5EF7F0-F248-11E8-B48F-1D18A9856A87","publisher":"Nature Publishing Group","title":"Activity dependent plasticity of hippocampal place maps","has_accepted_license":"1","publication":"Nature Communications","date_created":"2018-12-11T11:51:26Z","type":"journal_article","department":[{"_id":"JoCs"}],"language":[{"iso":"eng"}],"pubrep_id":"660","publist_id":"5934","quality_controlled":"1","volume":7,"abstract":[{"lang":"eng","text":"Hippocampal neurons encode a cognitive map of space. These maps are thought to be updated during learning and in response to changes in the environment through activity-dependent synaptic plasticity. Here we examine how changes in activity influence spatial coding in rats using halorhodopsin-mediated, spatially selective optogenetic silencing. Halorhoposin stimulation leads to light-induced suppression in many place cells and interneurons; some place cells increase their firing through disinhibition, whereas some show no effect. We find that place fields of the unaffected subpopulation remain stable. On the other hand, place fields of suppressed place cells were unstable, showing remapping across sessions before and after optogenetic inhibition. Disinhibited place cells had stable maps but sustained an elevated firing rate. These findings suggest that place representation in the hippocampus is constantly governed by activity-dependent processes, and that disinhibition may provide a mechanism for rate remapping."}],"date_updated":"2021-01-12T06:49:57Z","year":"2016","article_number":"11824","_id":"1334","status":"public","oa":1,"month":"06","ec_funded":1,"doi":"10.1038/ncomms11824","publication_status":"published","oa_version":"Published Version","date_published":"2016-06-10T00:00:00Z","scopus_import":1,"file_date_updated":"2020-07-14T12:44:44Z","ddc":["570"],"citation":{"mla":"Schönenberger, Philipp, et al. “Activity Dependent Plasticity of Hippocampal Place Maps.” <i>Nature Communications</i>, vol. 7, 11824, Nature Publishing Group, 2016, doi:<a href=\"https://doi.org/10.1038/ncomms11824\">10.1038/ncomms11824</a>.","apa":"Schönenberger, P., O’Neill, J., &#38; Csicsvari, J. L. (2016). Activity dependent plasticity of hippocampal place maps. <i>Nature Communications</i>. Nature Publishing Group. <a href=\"https://doi.org/10.1038/ncomms11824\">https://doi.org/10.1038/ncomms11824</a>","ista":"Schönenberger P, O’Neill J, Csicsvari JL. 2016. Activity dependent plasticity of hippocampal place maps. Nature Communications. 7, 11824.","chicago":"Schönenberger, Philipp, Joseph O’Neill, and Jozsef L Csicsvari. “Activity Dependent Plasticity of Hippocampal Place Maps.” <i>Nature Communications</i>. Nature Publishing Group, 2016. <a href=\"https://doi.org/10.1038/ncomms11824\">https://doi.org/10.1038/ncomms11824</a>.","ieee":"P. Schönenberger, J. O’Neill, and J. L. Csicsvari, “Activity dependent plasticity of hippocampal place maps,” <i>Nature Communications</i>, vol. 7. Nature Publishing Group, 2016.","ama":"Schönenberger P, O’Neill J, Csicsvari JL. Activity dependent plasticity of hippocampal place maps. <i>Nature Communications</i>. 2016;7. doi:<a href=\"https://doi.org/10.1038/ncomms11824\">10.1038/ncomms11824</a>","short":"P. Schönenberger, J. O’Neill, J.L. Csicsvari, Nature Communications 7 (2016)."},"intvolume":"         7"},{"pubrep_id":"690","publist_id":"6037","volume":11,"quality_controlled":"1","publication":"PLoS One","date_created":"2018-12-11T11:51:06Z","has_accepted_license":"1","department":[{"_id":"JoCs"}],"language":[{"iso":"eng"}],"type":"journal_article","title":"Optogenetically blocking sharp wave ripple events in sleep does not interfere with the formation of stable spatial representation in the CA1 area of the hippocampus","user_id":"3E5EF7F0-F248-11E8-B48F-1D18A9856A87","publisher":"Public Library of Science","tmp":{"short":"CC BY (4.0)","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"day":"19","acknowledgement":"The research leading to these results has received funding from the People Programme (Marie Curie Actions) of the European Union's Seventh Framework Programme (FP7/2007-2013) under REA grant agreement n° [291734] via the IST FELLOWSHIP awarded to Dr. Krisztián A. Kovács and the European Research Council starting grant (acronym: HIPECMEM Project reference: 281511) awarded to Dr. Jozsef Csicsvari. We thank Lauri Viljanto for technical help in building the ripple detector.","file":[{"file_size":4353592,"content_type":"application/pdf","relation":"main_file","access_level":"open_access","file_id":"5009","creator":"system","checksum":"395895ecb2216e9c39135abaa56b28b3","date_created":"2018-12-12T10:13:26Z","date_updated":"2020-07-14T12:44:42Z","file_name":"IST-2016-690-v1+1_journal.pone.0164675.PDF"}],"author":[{"last_name":"Kovács","id":"2AB5821E-F248-11E8-B48F-1D18A9856A87","first_name":"Krisztián","full_name":"Kovács, Krisztián"},{"last_name":"O'Neill","id":"426376DC-F248-11E8-B48F-1D18A9856A87","first_name":"Joseph","full_name":"O'Neill, Joseph"},{"full_name":"Schönenberger, Philipp","first_name":"Philipp","last_name":"Schönenberger","id":"3B9D816C-F248-11E8-B48F-1D18A9856A87"},{"first_name":"Markku","last_name":"Penttonen","full_name":"Penttonen, Markku"},{"full_name":"Rangel Guerrero, Dámaris K","last_name":"Rangel Guerrero","id":"4871BCE6-F248-11E8-B48F-1D18A9856A87","first_name":"Dámaris K","orcid":"0000-0002-8602-4374"},{"orcid":"0000-0002-5193-4036","first_name":"Jozsef L","id":"3FA14672-F248-11E8-B48F-1D18A9856A87","last_name":"Csicsvari","full_name":"Csicsvari, Jozsef L"}],"project":[{"grant_number":"291734","_id":"25681D80-B435-11E9-9278-68D0E5697425","name":"International IST Postdoc Fellowship Programme","call_identifier":"FP7"},{"name":"Memory-related information processing in neuronal circuits of the hippocampus and entorhinal cortex","call_identifier":"FP7","grant_number":"281511","_id":"257A4776-B435-11E9-9278-68D0E5697425"}],"ddc":["570","571"],"scopus_import":1,"file_date_updated":"2020-07-14T12:44:42Z","citation":{"short":"K. Kovács, J. O’Neill, P. Schönenberger, M. Penttonen, D.K. Rangel Guerrero, J.L. Csicsvari, PLoS One 11 (2016).","ieee":"K. Kovács, J. O’Neill, P. Schönenberger, M. Penttonen, D. K. Rangel Guerrero, and J. L. Csicsvari, “Optogenetically blocking sharp wave ripple events in sleep does not interfere with the formation of stable spatial representation in the CA1 area of the hippocampus,” <i>PLoS One</i>, vol. 11, no. 10. Public Library of Science, 2016.","ama":"Kovács K, O’Neill J, Schönenberger P, Penttonen M, Rangel Guerrero DK, Csicsvari JL. Optogenetically blocking sharp wave ripple events in sleep does not interfere with the formation of stable spatial representation in the CA1 area of the hippocampus. <i>PLoS One</i>. 2016;11(10). doi:<a href=\"https://doi.org/10.1371/journal.pone.0164675\">10.1371/journal.pone.0164675</a>","chicago":"Kovács, Krisztián, Joseph O’Neill, Philipp Schönenberger, Markku Penttonen, Dámaris K Rangel Guerrero, and Jozsef L Csicsvari. “Optogenetically Blocking Sharp Wave Ripple Events in Sleep Does Not Interfere with the Formation of Stable Spatial Representation in the CA1 Area of the Hippocampus.” <i>PLoS One</i>. Public Library of Science, 2016. <a href=\"https://doi.org/10.1371/journal.pone.0164675\">https://doi.org/10.1371/journal.pone.0164675</a>.","ista":"Kovács K, O’Neill J, Schönenberger P, Penttonen M, Rangel Guerrero DK, Csicsvari JL. 2016. Optogenetically blocking sharp wave ripple events in sleep does not interfere with the formation of stable spatial representation in the CA1 area of the hippocampus. PLoS One. 11(10), e0164675.","mla":"Kovács, Krisztián, et al. “Optogenetically Blocking Sharp Wave Ripple Events in Sleep Does Not Interfere with the Formation of Stable Spatial Representation in the CA1 Area of the Hippocampus.” <i>PLoS One</i>, vol. 11, no. 10, e0164675, Public Library of Science, 2016, doi:<a href=\"https://doi.org/10.1371/journal.pone.0164675\">10.1371/journal.pone.0164675</a>.","apa":"Kovács, K., O’Neill, J., Schönenberger, P., Penttonen, M., Rangel Guerrero, D. K., &#38; Csicsvari, J. L. (2016). Optogenetically blocking sharp wave ripple events in sleep does not interfere with the formation of stable spatial representation in the CA1 area of the hippocampus. <i>PLoS One</i>. Public Library of Science. <a href=\"https://doi.org/10.1371/journal.pone.0164675\">https://doi.org/10.1371/journal.pone.0164675</a>"},"intvolume":"        11","doi":"10.1371/journal.pone.0164675","publication_status":"published","date_published":"2016-10-19T00:00:00Z","oa_version":"Published Version","oa":1,"status":"public","ec_funded":1,"month":"10","year":"2016","issue":"10","abstract":[{"lang":"eng","text":"During hippocampal sharp wave/ripple (SWR) events, previously occurring, sensory inputdriven neuronal firing patterns are replayed. Such replay is thought to be important for plasticity- related processes and consolidation of memory traces. It has previously been shown that the electrical stimulation-induced disruption of SWR events interferes with learning in rodents in different experimental paradigms. On the other hand, the cognitive map theory posits that the plastic changes of the firing of hippocampal place cells constitute the electrophysiological counterpart of the spatial learning, observable at the behavioral level. Therefore, we tested whether intact SWR events occurring during the sleep/rest session after the first exploration of a novel environment are needed for the stabilization of the CA1 code, which process requires plasticity. We found that the newly-formed representation in the CA1 has the same level of stability with optogenetic SWR blockade as with a control manipulation that delivered the same amount of light into the brain. Therefore our results suggest that at least in the case of passive exploratory behavior, SWR-related plasticity is dispensable for the stability of CA1 ensembles."}],"date_updated":"2021-01-12T06:49:35Z","_id":"1279","article_number":"e0164675"},{"publication_status":"published","doi":"10.1016/j.neuron.2013.01.021","date_created":"2018-12-11T11:59:54Z","page":"1109 - 1121","publication":"Neuron","type":"journal_article","oa_version":"None","language":[{"iso":"eng"}],"date_published":"2013-03-20T00:00:00Z","department":[{"_id":"JoCs"}],"publist_id":"3949","scopus_import":1,"volume":77,"intvolume":"        77","citation":{"short":"T. Rose, P. Schönenberger, K. Jezek, T. Oertner, Neuron 77 (2013) 1109–1121.","ieee":"T. Rose, P. Schönenberger, K. Jezek, and T. Oertner, “Developmental refinement of vesicle cycling at Schaffer collateral synapses,” <i>Neuron</i>, vol. 77, no. 6. Elsevier, pp. 1109–1121, 2013.","ama":"Rose T, Schönenberger P, Jezek K, Oertner T. Developmental refinement of vesicle cycling at Schaffer collateral synapses. <i>Neuron</i>. 2013;77(6):1109-1121. doi:<a href=\"https://doi.org/10.1016/j.neuron.2013.01.021\">10.1016/j.neuron.2013.01.021</a>","chicago":"Rose, Tobias, Philipp Schönenberger, Karel Jezek, and Thomas Oertner. “Developmental Refinement of Vesicle Cycling at Schaffer Collateral Synapses.” <i>Neuron</i>. Elsevier, 2013. <a href=\"https://doi.org/10.1016/j.neuron.2013.01.021\">https://doi.org/10.1016/j.neuron.2013.01.021</a>.","ista":"Rose T, Schönenberger P, Jezek K, Oertner T. 2013. Developmental refinement of vesicle cycling at Schaffer collateral synapses. Neuron. 77(6), 1109–1121.","mla":"Rose, Tobias, et al. “Developmental Refinement of Vesicle Cycling at Schaffer Collateral Synapses.” <i>Neuron</i>, vol. 77, no. 6, Elsevier, 2013, pp. 1109–21, doi:<a href=\"https://doi.org/10.1016/j.neuron.2013.01.021\">10.1016/j.neuron.2013.01.021</a>.","apa":"Rose, T., Schönenberger, P., Jezek, K., &#38; Oertner, T. (2013). Developmental refinement of vesicle cycling at Schaffer collateral synapses. <i>Neuron</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.neuron.2013.01.021\">https://doi.org/10.1016/j.neuron.2013.01.021</a>"},"quality_controlled":"1","date_updated":"2021-01-12T07:00:11Z","issue":"6","abstract":[{"text":"At synapses formed between dissociated neurons, about half of all synaptic vesicles are refractory to evoked release, forming the so-called &quot;resting pool.&quot; Here, we use optical measurements of vesicular pH to study developmental changes in pool partitioning and vesicle cycling in cultured hippocampal slices. Two-photon imaging of a genetically encoded two-color release sensor (ratio-sypHy) allowed us to perform calibrated measurements at individual Schaffer collateral boutons. Mature boutons released a large fraction of their vesicles during simulated place field activity, and vesicle retrieval rates were 7-fold higher compared to immature boutons. Saturating stimulation mobilized essentially all vesicles at mature synapses. Resting pool formation and a concomitant reduction in evoked release was induced by chronic depolarization but not by acute inhibition of the protein phosphatase calcineurin. We conclude that synapses in CA1 undergo a prominent refinement of vesicle use during early postnatal development that is not recapitulated in dissociated neuronal culture.","lang":"eng"}],"day":"20","year":"2013","author":[{"full_name":"Rose, Tobias","last_name":"Rose","first_name":"Tobias"},{"last_name":"Schönenberger","id":"3B9D816C-F248-11E8-B48F-1D18A9856A87","first_name":"Philipp","full_name":"Schönenberger, Philipp"},{"full_name":"Jezek, Karel","last_name":"Jezek","first_name":"Karel"},{"last_name":"Oertner","first_name":"Thomas","full_name":"Oertner, Thomas"}],"_id":"2845","status":"public","publisher":"Elsevier","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","title":"Developmental refinement of vesicle cycling at Schaffer collateral synapses","month":"03"}]