---
_id: '1615'
abstract:
- lang: eng
  text: Loss-of-function mutations in the synaptic adhesion protein Neuroligin-4 are
    among the most common genetic abnormalities associated with autism spectrum disorders,
    but little is known about the function of Neuroligin-4 and the consequences of
    its loss. We assessed synaptic and network characteristics in Neuroligin-4 knockout
    mice, focusing on the hippocampus as a model brain region with a critical role
    in cognition and memory, and found that Neuroligin-4 deletion causes subtle defects
    of the protein composition and function of GABAergic synapses in the hippocampal
    CA3 region. Interestingly, these subtle synaptic changes are accompanied by pronounced
    perturbations of γ-oscillatory network activity, which has been implicated in
    cognitive function and is altered in multiple psychiatric and neurodevelopmental
    disorders. Our data provide important insights into the mechanisms by which Neuroligin-4-dependent
    GABAergic synapses may contribute to autism phenotypes and indicate new strategies
    for therapeutic approaches.
acknowledgement: This work was supported by the Max Planck Society (N.B. and H.E.),
  the European Commission (EU-AIMS FP7-115300, N.B. and H.E.; Marie Curie IRG, D.K.-B.),
  the German Research Foundation (CNMPB, N.B., H.E., and F.V.), the Alexander von
  Humboldt-Foundation (D.K.-B.), and the Austrian Fond zur Förderung der Wissenschaftlichen
  Forschung (P 24909-B24, P.J.). M.H. was a student of the doctoral program Molecular
  Physiology of the Brain. Dr. J.-M. Fritschy generously provided the GABAARγ2 antibody.
  We thank F. Benseler, I. Thanhäuser, D. Schwerdtfeger, A. Ronnenberg, and D. Winkler
  for valuable advice and excellent technical support. We are grateful to the staff
  at the animal facility of the Max Planck Institute of Experimental Medicine for
  mouse husbandry.
author:
- first_name: Matthieu
  full_name: Hammer, Matthieu
  last_name: Hammer
- first_name: Dilja
  full_name: Krueger Burg, Dilja
  last_name: Krueger Burg
- first_name: Liam
  full_name: Tuffy, Liam
  last_name: Tuffy
- first_name: Benjamin
  full_name: Cooper, Benjamin
  last_name: Cooper
- first_name: Holger
  full_name: Taschenberger, Holger
  last_name: Taschenberger
- first_name: Sarit
  full_name: Goswami, Sarit
  id: 3A578F32-F248-11E8-B48F-1D18A9856A87
  last_name: Goswami
- first_name: Hannelore
  full_name: Ehrenreich, Hannelore
  last_name: Ehrenreich
- first_name: Peter M
  full_name: Jonas, Peter M
  id: 353C1B58-F248-11E8-B48F-1D18A9856A87
  last_name: Jonas
  orcid: 0000-0001-5001-4804
- first_name: Frederique
  full_name: Varoqueaux, Frederique
  last_name: Varoqueaux
- first_name: Jeong
  full_name: Rhee, Jeong
  last_name: Rhee
- first_name: Nils
  full_name: Brose, Nils
  last_name: Brose
citation:
  ama: Hammer M, Krueger Burg D, Tuffy L, et al. Perturbed hippocampal synaptic inhibition
    and γ-oscillations in a neuroligin-4 knockout mouse model of autism. <i>Cell Reports</i>.
    2015;13(3):516-523. doi:<a href="https://doi.org/10.1016/j.celrep.2015.09.011">10.1016/j.celrep.2015.09.011</a>
  apa: Hammer, M., Krueger Burg, D., Tuffy, L., Cooper, B., Taschenberger, H., Goswami,
    S., … Brose, N. (2015). Perturbed hippocampal synaptic inhibition and γ-oscillations
    in a neuroligin-4 knockout mouse model of autism. <i>Cell Reports</i>. Cell Press.
    <a href="https://doi.org/10.1016/j.celrep.2015.09.011">https://doi.org/10.1016/j.celrep.2015.09.011</a>
  chicago: Hammer, Matthieu, Dilja Krueger Burg, Liam Tuffy, Benjamin Cooper, Holger
    Taschenberger, Sarit Goswami, Hannelore Ehrenreich, et al. “Perturbed Hippocampal
    Synaptic Inhibition and γ-Oscillations in a Neuroligin-4 Knockout Mouse Model
    of Autism.” <i>Cell Reports</i>. Cell Press, 2015. <a href="https://doi.org/10.1016/j.celrep.2015.09.011">https://doi.org/10.1016/j.celrep.2015.09.011</a>.
  ieee: M. Hammer <i>et al.</i>, “Perturbed hippocampal synaptic inhibition and γ-oscillations
    in a neuroligin-4 knockout mouse model of autism,” <i>Cell Reports</i>, vol. 13,
    no. 3. Cell Press, pp. 516–523, 2015.
  ista: Hammer M, Krueger Burg D, Tuffy L, Cooper B, Taschenberger H, Goswami S, Ehrenreich
    H, Jonas PM, Varoqueaux F, Rhee J, Brose N. 2015. Perturbed hippocampal synaptic
    inhibition and γ-oscillations in a neuroligin-4 knockout mouse model of autism.
    Cell Reports. 13(3), 516–523.
  mla: Hammer, Matthieu, et al. “Perturbed Hippocampal Synaptic Inhibition and γ-Oscillations
    in a Neuroligin-4 Knockout Mouse Model of Autism.” <i>Cell Reports</i>, vol. 13,
    no. 3, Cell Press, 2015, pp. 516–23, doi:<a href="https://doi.org/10.1016/j.celrep.2015.09.011">10.1016/j.celrep.2015.09.011</a>.
  short: M. Hammer, D. Krueger Burg, L. Tuffy, B. Cooper, H. Taschenberger, S. Goswami,
    H. Ehrenreich, P.M. Jonas, F. Varoqueaux, J. Rhee, N. Brose, Cell Reports 13 (2015)
    516–523.
date_created: 2018-12-11T11:53:02Z
date_published: 2015-10-20T00:00:00Z
date_updated: 2021-01-12T06:52:01Z
day: '20'
ddc:
- '570'
department:
- _id: PeJo
doi: 10.1016/j.celrep.2015.09.011
file:
- access_level: open_access
  checksum: 44d30fbb543774b076b4938bd36af9d7
  content_type: application/pdf
  creator: system
  date_created: 2018-12-12T10:13:23Z
  date_updated: 2020-07-14T12:45:07Z
  file_id: '5005'
  file_name: IST-2016-470-v1+1_1-s2.0-S2211124715010220-main.pdf
  file_size: 2314406
  relation: main_file
file_date_updated: 2020-07-14T12:45:07Z
has_accepted_license: '1'
intvolume: '        13'
issue: '3'
language:
- iso: eng
month: '10'
oa: 1
oa_version: Published Version
page: 516 - 523
publication: Cell Reports
publication_status: published
publisher: Cell Press
publist_id: '5551'
pubrep_id: '470'
quality_controlled: '1'
scopus_import: 1
status: public
title: Perturbed hippocampal synaptic inhibition and γ-oscillations in a neuroligin-4
  knockout mouse model of autism
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 13
year: '2015'
...
---
_id: '2954'
abstract:
- lang: eng
  text: Spontaneous postsynaptic currents (PSCs) provide key information about the
    mechanisms of synaptic transmission and the activity modes of neuronal networks.
    However, detecting spontaneous PSCs in vitro and in vivo has been challenging,
    because of the small amplitude, the variable kinetics, and the undefined time
    of generation of these events. Here, we describe a, to our knowledge, new method
    for detecting spontaneous synaptic events by deconvolution, using a template that
    approximates the average time course of spontaneous PSCs. A recorded PSC trace
    is deconvolved from the template, resulting in a series of delta-like functions.
    The maxima of these delta-like events are reliably detected, revealing the precise
    onset times of the spontaneous PSCs. Among all detection methods, the deconvolution-based
    method has a unique temporal resolution, allowing the detection of individual
    events in high-frequency bursts. Furthermore, the deconvolution-based method has
    a high amplitude resolution, because deconvolution can substantially increase
    the signal/noise ratio. When tested against previously published methods using
    experimental data, the deconvolution-based method was superior for spontaneous
    PSCs recorded in vivo. Using the high-resolution deconvolution-based detection
    algorithm, we show that the frequency of spontaneous excitatory postsynaptic currents
    in dentate gyrus granule cells is 4.5 times higher in vivo than in vitro.
acknowledgement: "This work was supported by the Deutsche Forschungsgemeinschaft (TR3/B10)
  and a European Research Council Advanced grant to P.J.\r\nWe thank H. Hu, S. J.
  Guzman, and C. Schmidt-Hieber for critically reading the manuscript, I. Koeva and
  F. Marr for technical support, and E. Kramberger for editorial assistance.\r\n"
author:
- first_name: Alejandro
  full_name: Pernia-Andrade, Alejandro
  id: 36963E98-F248-11E8-B48F-1D18A9856A87
  last_name: Pernia-Andrade
- first_name: Sarit
  full_name: Goswami, Sarit
  id: 3A578F32-F248-11E8-B48F-1D18A9856A87
  last_name: Goswami
- first_name: Yvonne
  full_name: Stickler, Yvonne
  id: 63B76600-E9CC-11E9-9B5F-82450873F7A1
  last_name: Stickler
- first_name: Ulrich
  full_name: Fröbe, Ulrich
  last_name: Fröbe
- first_name: Alois
  full_name: Schlögl, Alois
  id: 45BF87EE-F248-11E8-B48F-1D18A9856A87
  last_name: Schlögl
  orcid: 0000-0002-5621-8100
- first_name: Peter M
  full_name: Jonas, Peter M
  id: 353C1B58-F248-11E8-B48F-1D18A9856A87
  last_name: Jonas
  orcid: 0000-0001-5001-4804
citation:
  ama: Pernia-Andrade A, Goswami S, Stickler Y, Fröbe U, Schlögl A, Jonas PM. A deconvolution
    based method with high sensitivity and temporal resolution for detection of spontaneous
    synaptic currents in vitro and in vivo. <i>Biophysical Journal</i>. 2012;103(7):1429-1439.
    doi:<a href="https://doi.org/10.1016/j.bpj.2012.08.039">10.1016/j.bpj.2012.08.039</a>
  apa: Pernia-Andrade, A., Goswami, S., Stickler, Y., Fröbe, U., Schlögl, A., &#38;
    Jonas, P. M. (2012). A deconvolution based method with high sensitivity and temporal
    resolution for detection of spontaneous synaptic currents in vitro and in vivo.
    <i>Biophysical Journal</i>. Biophysical. <a href="https://doi.org/10.1016/j.bpj.2012.08.039">https://doi.org/10.1016/j.bpj.2012.08.039</a>
  chicago: Pernia-Andrade, Alejandro, Sarit Goswami, Yvonne Stickler, Ulrich Fröbe,
    Alois Schlögl, and Peter M Jonas. “A Deconvolution Based Method with High Sensitivity
    and Temporal Resolution for Detection of Spontaneous Synaptic Currents in Vitro
    and in Vivo.” <i>Biophysical Journal</i>. Biophysical, 2012. <a href="https://doi.org/10.1016/j.bpj.2012.08.039">https://doi.org/10.1016/j.bpj.2012.08.039</a>.
  ieee: A. Pernia-Andrade, S. Goswami, Y. Stickler, U. Fröbe, A. Schlögl, and P. M.
    Jonas, “A deconvolution based method with high sensitivity and temporal resolution
    for detection of spontaneous synaptic currents in vitro and in vivo,” <i>Biophysical
    Journal</i>, vol. 103, no. 7. Biophysical, pp. 1429–1439, 2012.
  ista: Pernia-Andrade A, Goswami S, Stickler Y, Fröbe U, Schlögl A, Jonas PM. 2012.
    A deconvolution based method with high sensitivity and temporal resolution for
    detection of spontaneous synaptic currents in vitro and in vivo. Biophysical Journal.
    103(7), 1429–1439.
  mla: Pernia-Andrade, Alejandro, et al. “A Deconvolution Based Method with High Sensitivity
    and Temporal Resolution for Detection of Spontaneous Synaptic Currents in Vitro
    and in Vivo.” <i>Biophysical Journal</i>, vol. 103, no. 7, Biophysical, 2012,
    pp. 1429–39, doi:<a href="https://doi.org/10.1016/j.bpj.2012.08.039">10.1016/j.bpj.2012.08.039</a>.
  short: A. Pernia-Andrade, S. Goswami, Y. Stickler, U. Fröbe, A. Schlögl, P.M. Jonas,
    Biophysical Journal 103 (2012) 1429–1439.
date_created: 2018-12-11T12:00:32Z
date_published: 2012-10-03T00:00:00Z
date_updated: 2021-01-12T07:40:01Z
day: '03'
department:
- _id: PeJo
- _id: ScienComp
doi: 10.1016/j.bpj.2012.08.039
external_id:
  pmid:
  - '23062335'
intvolume: '       103'
issue: '7'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3471482/
month: '10'
oa: 1
oa_version: Submitted Version
page: 1429 - 1439
pmid: 1
project:
- _id: 25BDE9A4-B435-11E9-9278-68D0E5697425
  grant_number: SFB-TR3-TP10B
  name: Glutamaterge synaptische Übertragung und Plastizität in hippocampalen Mikroschaltkreisen
publication: Biophysical Journal
publication_status: published
publisher: Biophysical
publist_id: '3774'
quality_controlled: '1'
scopus_import: 1
status: public
title: A deconvolution based method with high sensitivity and temporal resolution
  for detection of spontaneous synaptic currents in vitro and in vivo
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 103
year: '2012'
...
---
_id: '2969'
abstract:
- lang: eng
  text: "The coupling between presynaptic Ca^(2+) channels and Ca^(2+) sensors of
    exocytosis is a key determinant of synaptic transmission. Evoked release from
    parvalbumin (PV)-expressing interneurons is triggered by nanodomain coupling of
    P/Q-type Ca^(2+) channels, whereas release from cholecystokinin (CCK)-containing
    interneurons is generated by microdomain coupling of N-type channels. Nanodomain
    coupling has several functional advantages, including speed and efficacy of transmission.
    One potential disadvantage is that stochastic\r\nopening of presynaptic Ca^(2+)
    channels may trigger spontaneous transmitter release. We addressed this possibility
    in rat hippocampal\r\ngranule cells, which receive converging inputs from different
    inhibitory sources. Both reduction of extracellular Ca^(2+) concentration and
    the unselective Ca^(2+) channel blocker Cd^(2+) reduced the frequency of miniature
    IPSCs (mIPSCs) in granule cells by ~50%, suggesting that the opening of presynaptic
    Ca^(2+) channels contributes to spontaneous release. Application of the selective
    P/Q-type Ca^(2+) channel blocker\r\nω-agatoxin IVa had no detectable effects,
    whereas both the N-type blocker ω-conotoxin GVIa and the L-type blocker nimodipine
    reduced\r\nmIPSC frequency. Furthermore, both the fast Ca^(2+) chelator BAPTA-AM
    and the slow chelator EGTA-AM reduced the mIPSC frequency,\r\nsuggesting that
    Ca^(2+)-dependent spontaneous release is triggered by microdomain rather than
    nanodomain coupling. The CB_(1) receptor\r\nagonist WIN 55212-2 also decreased
    spontaneous release; this effect was occluded by prior application of ω-conotoxin
    GVIa, suggesting that a major fraction of Ca^(2+)-dependent spontaneous release
    was generated at the terminals of CCK-expressing interneurons. Tonic inhibition
    generated by spontaneous opening of presynaptic N- and L-type Ca^(2+) channels
    may be important for hippocampal information processing.\r\n"
acknowledgement: This work was supported by grants from the Deutsche Forschungsgemeinschaft
  (TR 3/B10, Leibniz program, GSC-4 Spemann Graduate School) and the European Union
  (European Research Council Advanced Grant).
author:
- first_name: Sarit
  full_name: Goswami, Sarit
  id: 3A578F32-F248-11E8-B48F-1D18A9856A87
  last_name: Goswami
- first_name: Iancu
  full_name: Bucurenciu, Iancu
  last_name: Bucurenciu
- first_name: Peter M
  full_name: Jonas, Peter M
  id: 353C1B58-F248-11E8-B48F-1D18A9856A87
  last_name: Jonas
  orcid: 0000-0001-5001-4804
citation:
  ama: Goswami S, Bucurenciu I, Jonas PM. Miniature IPSCs in hippocampal granule cells
    are triggered by voltage-gated Ca^(2+) channels via microdomain coupling. <i>Journal
    of Neuroscience</i>. 2012;32(41):14294-14304. doi:<a href="https://doi.org/10.1523/JNEUROSCI.6104-11.2012">10.1523/JNEUROSCI.6104-11.2012</a>
  apa: Goswami, S., Bucurenciu, I., &#38; Jonas, P. M. (2012). Miniature IPSCs in
    hippocampal granule cells are triggered by voltage-gated Ca^(2+) channels via
    microdomain coupling. <i>Journal of Neuroscience</i>. Society for Neuroscience.
    <a href="https://doi.org/10.1523/JNEUROSCI.6104-11.2012">https://doi.org/10.1523/JNEUROSCI.6104-11.2012</a>
  chicago: Goswami, Sarit, Iancu Bucurenciu, and Peter M Jonas. “Miniature IPSCs in
    Hippocampal Granule Cells Are Triggered by Voltage-Gated Ca^(2+) Channels via
    Microdomain Coupling.” <i>Journal of Neuroscience</i>. Society for Neuroscience,
    2012. <a href="https://doi.org/10.1523/JNEUROSCI.6104-11.2012">https://doi.org/10.1523/JNEUROSCI.6104-11.2012</a>.
  ieee: S. Goswami, I. Bucurenciu, and P. M. Jonas, “Miniature IPSCs in hippocampal
    granule cells are triggered by voltage-gated Ca^(2+) channels via microdomain
    coupling,” <i>Journal of Neuroscience</i>, vol. 32, no. 41. Society for Neuroscience,
    pp. 14294–14304, 2012.
  ista: Goswami S, Bucurenciu I, Jonas PM. 2012. Miniature IPSCs in hippocampal granule
    cells are triggered by voltage-gated Ca^(2+) channels via microdomain coupling.
    Journal of Neuroscience. 32(41), 14294–14304.
  mla: Goswami, Sarit, et al. “Miniature IPSCs in Hippocampal Granule Cells Are Triggered
    by Voltage-Gated Ca^(2+) Channels via Microdomain Coupling.” <i>Journal of Neuroscience</i>,
    vol. 32, no. 41, Society for Neuroscience, 2012, pp. 14294–304, doi:<a href="https://doi.org/10.1523/JNEUROSCI.6104-11.2012">10.1523/JNEUROSCI.6104-11.2012</a>.
  short: S. Goswami, I. Bucurenciu, P.M. Jonas, Journal of Neuroscience 32 (2012)
    14294–14304.
date_created: 2018-12-11T12:00:36Z
date_published: 2012-10-10T00:00:00Z
date_updated: 2021-01-12T07:40:08Z
day: '10'
department:
- _id: PeJo
doi: 10.1523/JNEUROSCI.6104-11.2012
external_id:
  pmid:
  - '23055500'
intvolume: '        32'
issue: '41'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3632771/
month: '10'
oa: 1
oa_version: Submitted Version
page: 14294 - 14304
pmid: 1
project:
- _id: 25BDE9A4-B435-11E9-9278-68D0E5697425
  grant_number: SFB-TR3-TP10B
  name: Glutamaterge synaptische Übertragung und Plastizität in hippocampalen Mikroschaltkreisen
publication: Journal of Neuroscience
publication_status: published
publisher: Society for Neuroscience
publist_id: '3744'
quality_controlled: '1'
scopus_import: 1
status: public
title: Miniature IPSCs in hippocampal granule cells are triggered by voltage-gated
  Ca^(2+) channels via microdomain coupling
type: journal_article
user_id: 3E5EF7F0-F248-11E8-B48F-1D18A9856A87
volume: 32
year: '2012'
...
---
_id: '3317'
abstract:
- lang: eng
  text: The physical distance between presynaptic Ca2+ channels and the Ca2+ sensors
    that trigger exocytosis of neurotransmitter-containing vesicles is a key determinant
    of the signalling properties of synapses in the nervous system. Recent functional
    analysis indicates that in some fast central synapses, transmitter release is
    triggered by a small number of Ca2+ channels that are coupled to Ca2+ sensors
    at the nanometre scale. Molecular analysis suggests that this tight coupling is
    generated by protein–protein interactions involving Ca2+ channels, Ca2+ sensors
    and various other synaptic proteins. Nanodomain coupling has several functional
    advantages, as it increases the efficacy, speed and energy efficiency of synaptic
    transmission.
acknowledgement: "Work of the authors was funded by grants of the Deutsche Forschungsgemeinschaft
  to P.J. (grants SFB 780/A5, TR 3/B10 and the Leibniz programme), a European Research
  Council Advanced grant to P.J. and a Swiss National Foundation fellowship to E.E.\r\nWe
  thank D. Tsien and E. Neher for their comments on this Review, J. Guzmán and A.
  Pernía-Andrade for reading earlier versions and E. Kramberger for perfect editorial
  support. We apologize that owing to space constraints, not all relevant papers could
  be cited.\r\n"
author:
- first_name: Emmanuel
  full_name: Eggermann, Emmanuel
  id: 34DACA34-E9AE-11E9-849C-D35BD8ADC20C
  last_name: Eggermann
- first_name: Iancu
  full_name: Bucurenciu, Iancu
  id: 4BD1D872-E9AE-11E9-9EE9-8BF4597A9E2A
  last_name: Bucurenciu
- first_name: Sarit
  full_name: Goswami, Sarit
  id: 3A578F32-F248-11E8-B48F-1D18A9856A87
  last_name: Goswami
- first_name: Peter M
  full_name: Jonas, Peter M
  id: 353C1B58-F248-11E8-B48F-1D18A9856A87
  last_name: Jonas
  orcid: 0000-0001-5001-4804
citation:
  ama: Eggermann E, Bucurenciu I, Goswami S, Jonas PM. Nanodomain coupling between
    Ca(2+) channels and sensors of exocytosis at fast mammalian synapses. <i>Nature
    Reviews Neuroscience</i>. 2012;13(1):7-21. doi:<a href="https://doi.org/10.1038/nrn3125">10.1038/nrn3125</a>
  apa: Eggermann, E., Bucurenciu, I., Goswami, S., &#38; Jonas, P. M. (2012). Nanodomain
    coupling between Ca(2+) channels and sensors of exocytosis at fast mammalian synapses.
    <i>Nature Reviews Neuroscience</i>. Nature Publishing Group. <a href="https://doi.org/10.1038/nrn3125">https://doi.org/10.1038/nrn3125</a>
  chicago: Eggermann, Emmanuel, Iancu Bucurenciu, Sarit Goswami, and Peter M Jonas.
    “Nanodomain Coupling between Ca(2+) Channels and Sensors of Exocytosis at Fast
    Mammalian Synapses.” <i>Nature Reviews Neuroscience</i>. Nature Publishing Group,
    2012. <a href="https://doi.org/10.1038/nrn3125">https://doi.org/10.1038/nrn3125</a>.
  ieee: E. Eggermann, I. Bucurenciu, S. Goswami, and P. M. Jonas, “Nanodomain coupling
    between Ca(2+) channels and sensors of exocytosis at fast mammalian synapses,”
    <i>Nature Reviews Neuroscience</i>, vol. 13, no. 1. Nature Publishing Group, pp.
    7–21, 2012.
  ista: Eggermann E, Bucurenciu I, Goswami S, Jonas PM. 2012. Nanodomain coupling
    between Ca(2+) channels and sensors of exocytosis at fast mammalian synapses.
    Nature Reviews Neuroscience. 13(1), 7–21.
  mla: Eggermann, Emmanuel, et al. “Nanodomain Coupling between Ca(2+) Channels and
    Sensors of Exocytosis at Fast Mammalian Synapses.” <i>Nature Reviews Neuroscience</i>,
    vol. 13, no. 1, Nature Publishing Group, 2012, pp. 7–21, doi:<a href="https://doi.org/10.1038/nrn3125">10.1038/nrn3125</a>.
  short: E. Eggermann, I. Bucurenciu, S. Goswami, P.M. Jonas, Nature Reviews Neuroscience
    13 (2012) 7–21.
date_created: 2018-12-11T12:02:38Z
date_published: 2012-01-01T00:00:00Z
date_updated: 2021-01-12T07:42:36Z
day: '01'
ddc:
- '570'
department:
- _id: PeJo
doi: 10.1038/nrn3125
file:
- access_level: open_access
  checksum: 4c1c86b2f6e4e1562f5bb800b457ea9f
  content_type: application/pdf
  creator: system
  date_created: 2018-12-12T10:12:13Z
  date_updated: 2020-07-14T12:46:07Z
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  file_name: IST-2017-820-v1+1_17463_3_art_file_109404_ltmxbw.pdf
  file_size: 314246
  relation: main_file
- access_level: open_access
  checksum: bceb2efdd49d115f4dde8486bc1be3f2
  content_type: application/pdf
  creator: system
  date_created: 2018-12-12T10:12:14Z
  date_updated: 2020-07-14T12:46:07Z
  file_id: '4932'
  file_name: IST-2017-820-v1+2_17463_3_figure_109402_ltmwlp.pdf
  file_size: 1840216
  relation: main_file
file_date_updated: 2020-07-14T12:46:07Z
has_accepted_license: '1'
intvolume: '        13'
issue: '1'
language:
- iso: eng
month: '01'
oa: 1
oa_version: Submitted Version
page: 7 - 21
project:
- _id: 25BC64A8-B435-11E9-9278-68D0E5697425
  grant_number: JO_780/A5
  name: Synaptic Mechanisms of Neuronal Network Function
- _id: 25BDE9A4-B435-11E9-9278-68D0E5697425
  grant_number: SFB-TR3-TP10B
  name: Glutamaterge synaptische Übertragung und Plastizität in hippocampalen Mikroschaltkreisen
publication: Nature Reviews Neuroscience
publication_status: published
publisher: Nature Publishing Group
publist_id: '3322'
pubrep_id: '820'
quality_controlled: '1'
scopus_import: 1
status: public
title: Nanodomain coupling between Ca(2+) channels and sensors of exocytosis at fast
  mammalian synapses
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 13
year: '2012'
...
---
_id: '3294'
abstract:
- lang: eng
  text: 'Olfactory responses of Drosophila undergo pronounced changes after eclosion.
    The flies develop attraction to odors to which they are exposed and aversion to
    other odors. Behavioral adaptation is correlated with changes in the firing pattern
    of olfactory receptor neurons (ORNs). In this article, we present an information-theoretic
    analysis of the firing pattern of ORNs. Flies reared in a synthetic odorless medium
    were transferred after eclosion to three different media: (i) a synthetic medium
    relatively devoid of odor cues, (ii) synthetic medium infused with a single odorant,
    and (iii) complex cornmeal medium rich in odors. Recordings were made from an
    identified sensillum (type II), and the Jensen-Shannon divergence (D(JS)) was
    used to assess quantitatively the differences between ensemble spike responses
    to different odors. Analysis shows that prolonged exposure to ethyl acetate and
    several related esters increases sensitivity to these esters but does not improve
    the ability of the fly to distinguish between them. Flies exposed to cornmeal
    display varied sensitivity to these odorants and at the same time develop greater
    capacity to distinguish between odors. Deprivation of odor experience on an odorless
    synthetic medium leads to a loss of both sensitivity and acuity. Rich olfactory
    experience thus helps to shape the ORNs response and enhances its discriminative
    power. The experiments presented here demonstrate an experience-dependent adaptation
    at the level of the receptor neuron.'
author:
- first_name: Atulya
  full_name: Iyengar, Atulya
  last_name: Iyengar
- first_name: Subhra
  full_name: Chakraborty Tuhin, Subhra
  last_name: Chakraborty Tuhin
- first_name: Sarit
  full_name: Sarit Goswami
  id: 3A578F32-F248-11E8-B48F-1D18A9856A87
  last_name: Goswami
- first_name: Chun
  full_name: Wu, Chun Fang
  last_name: Wu
- first_name: Obaid
  full_name: Siddiqi, Obaid
  last_name: Siddiqi
citation:
  ama: Iyengar A, Chakraborty Tuhin S, Goswami S, Wu C, Siddiqi O. Post eclosion odor
    experience modifies olfactory receptor neuron coding in Drosophila. <i>PNAS</i>.
    2010;107(21):9855-9860. doi:<a href="https://doi.org/10.1073/pnas.1003856107">10.1073/pnas.1003856107</a>
  apa: Iyengar, A., Chakraborty Tuhin, S., Goswami, S., Wu, C., &#38; Siddiqi, O.
    (2010). Post eclosion odor experience modifies olfactory receptor neuron coding
    in Drosophila. <i>PNAS</i>. National Academy of Sciences. <a href="https://doi.org/10.1073/pnas.1003856107">https://doi.org/10.1073/pnas.1003856107</a>
  chicago: Iyengar, Atulya, Subhra Chakraborty Tuhin, Sarit Goswami, Chun Wu, and
    Obaid Siddiqi. “Post Eclosion Odor Experience Modifies Olfactory Receptor Neuron
    Coding in Drosophila.” <i>PNAS</i>. National Academy of Sciences, 2010. <a href="https://doi.org/10.1073/pnas.1003856107">https://doi.org/10.1073/pnas.1003856107</a>.
  ieee: A. Iyengar, S. Chakraborty Tuhin, S. Goswami, C. Wu, and O. Siddiqi, “Post
    eclosion odor experience modifies olfactory receptor neuron coding in Drosophila,”
    <i>PNAS</i>, vol. 107, no. 21. National Academy of Sciences, pp. 9855–60, 2010.
  ista: Iyengar A, Chakraborty Tuhin S, Goswami S, Wu C, Siddiqi O. 2010. Post eclosion
    odor experience modifies olfactory receptor neuron coding in Drosophila. PNAS.
    107(21), 9855–60.
  mla: Iyengar, Atulya, et al. “Post Eclosion Odor Experience Modifies Olfactory Receptor
    Neuron Coding in Drosophila.” <i>PNAS</i>, vol. 107, no. 21, National Academy
    of Sciences, 2010, pp. 9855–60, doi:<a href="https://doi.org/10.1073/pnas.1003856107">10.1073/pnas.1003856107</a>.
  short: A. Iyengar, S. Chakraborty Tuhin, S. Goswami, C. Wu, O. Siddiqi, PNAS 107
    (2010) 9855–60.
date_created: 2018-12-11T12:02:31Z
date_published: 2010-01-01T00:00:00Z
date_updated: 2021-01-12T07:42:27Z
day: '01'
doi: 10.1073/pnas.1003856107
extern: 1
intvolume: '       107'
issue: '21'
month: '01'
page: 9855 - 60
publication: PNAS
publication_status: published
publisher: National Academy of Sciences
publist_id: '3347'
quality_controlled: 0
status: public
title: Post eclosion odor experience modifies olfactory receptor neuron coding in
  Drosophila
type: journal_article
volume: 107
year: '2010'
...
---
_id: '3293'
abstract:
- lang: eng
  text: Chemotactic responses of Drosophila to certain esters and alcohols are experience
    dependent. When the flies are exposed after eclosion to these chemicals, the odorants
    become strongly attractive. We show that behavioral conditioning is accompanied
    by an increase in the electrophysiological responses of single neurons in sensilla
    basiconica. Sensitization involves odorants that act on a common olfactory receptor.
    The possible mechanism of imaginal conditioning and its ecological and evolutionary
    significance are discussed.
author:
- first_name: Subhra
  full_name: Chakraborty Tuhin, Subhra
  last_name: Chakraborty Tuhin
- first_name: Sarit
  full_name: Sarit Goswami
  id: 3A578F32-F248-11E8-B48F-1D18A9856A87
  last_name: Goswami
- first_name: Obaid
  full_name: Siddiqi, Obaid
  last_name: Siddiqi
citation:
  ama: Chakraborty Tuhin S, Goswami S, Siddiqi O. Sensory correlates of imaginal conditioning
    in Drosophila melanogaster. <i>Journal of Neurogenetics</i>. 2009;23(1-2):210-219.
    doi:<a href="https://doi.org/10.1080/01677060802491559 ">10.1080/01677060802491559
    </a>
  apa: Chakraborty Tuhin, S., Goswami, S., &#38; Siddiqi, O. (2009). Sensory correlates
    of imaginal conditioning in Drosophila melanogaster. <i>Journal of Neurogenetics</i>.
    Informa Healthcare. <a href="https://doi.org/10.1080/01677060802491559 ">https://doi.org/10.1080/01677060802491559
    </a>
  chicago: Chakraborty Tuhin, Subhra, Sarit Goswami, and Obaid Siddiqi. “Sensory Correlates
    of Imaginal Conditioning in Drosophila Melanogaster.” <i>Journal of Neurogenetics</i>.
    Informa Healthcare, 2009. <a href="https://doi.org/10.1080/01677060802491559 ">https://doi.org/10.1080/01677060802491559
    </a>.
  ieee: S. Chakraborty Tuhin, S. Goswami, and O. Siddiqi, “Sensory correlates of imaginal
    conditioning in Drosophila melanogaster,” <i>Journal of Neurogenetics</i>, vol.
    23, no. 1–2. Informa Healthcare, pp. 210–9, 2009.
  ista: Chakraborty Tuhin S, Goswami S, Siddiqi O. 2009. Sensory correlates of imaginal
    conditioning in Drosophila melanogaster. Journal of Neurogenetics. 23(1–2), 210–9.
  mla: Chakraborty Tuhin, Subhra, et al. “Sensory Correlates of Imaginal Conditioning
    in Drosophila Melanogaster.” <i>Journal of Neurogenetics</i>, vol. 23, no. 1–2,
    Informa Healthcare, 2009, pp. 210–19, doi:<a href="https://doi.org/10.1080/01677060802491559
    ">10.1080/01677060802491559 </a>.
  short: S. Chakraborty Tuhin, S. Goswami, O. Siddiqi, Journal of Neurogenetics 23
    (2009) 210–9.
date_created: 2018-12-11T12:02:30Z
date_published: 2009-01-01T00:00:00Z
date_updated: 2021-01-12T07:42:27Z
day: '01'
doi: '10.1080/01677060802491559 '
extern: 1
intvolume: '        23'
issue: 1-2
month: '01'
page: 210 - 9
publication: Journal of Neurogenetics
publication_status: published
publisher: Informa Healthcare
publist_id: '3348'
quality_controlled: 0
status: public
title: Sensory correlates of imaginal conditioning in Drosophila melanogaster
type: journal_article
volume: 23
year: '2009'
...