[{"ddc":["570"],"tmp":{"image":"/images/cc_by.png","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)"},"pubrep_id":"470","title":"Perturbed hippocampal synaptic inhibition and γ-oscillations in a neuroligin-4 knockout mouse model of autism","doi":"10.1016/j.celrep.2015.09.011","year":"2015","_id":"1615","acknowledgement":"This work was supported by the Max Planck Society (N.B. and H.E.), the European Commission (EU-AIMS FP7-115300, N.B. and H.E.; Marie Curie IRG, D.K.-B.), the German Research Foundation (CNMPB, N.B., H.E., and F.V.), the Alexander von Humboldt-Foundation (D.K.-B.), and the Austrian Fond zur Förderung der Wissenschaftlichen Forschung (P 24909-B24, P.J.). M.H. was a student of the doctoral program Molecular Physiology of the Brain. Dr. J.-M. Fritschy generously provided the GABAARγ2 antibody. We thank F. Benseler, I. Thanhäuser, D. Schwerdtfeger, A. Ronnenberg, and D. Winkler for valuable advice and excellent technical support. We are grateful to the staff at the animal facility of the Max Planck Institute of Experimental Medicine for mouse husbandry.","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","oa_version":"Published Version","quality_controlled":"1","volume":13,"oa":1,"publist_id":"5551","date_updated":"2021-01-12T06:52:01Z","abstract":[{"lang":"eng","text":"Loss-of-function mutations in the synaptic adhesion protein Neuroligin-4 are among the most common genetic abnormalities associated with autism spectrum disorders, but little is known about the function of Neuroligin-4 and the consequences of its loss. We assessed synaptic and network characteristics in Neuroligin-4 knockout mice, focusing on the hippocampus as a model brain region with a critical role in cognition and memory, and found that Neuroligin-4 deletion causes subtle defects of the protein composition and function of GABAergic synapses in the hippocampal CA3 region. Interestingly, these subtle synaptic changes are accompanied by pronounced perturbations of γ-oscillatory network activity, which has been implicated in cognitive function and is altered in multiple psychiatric and neurodevelopmental disorders. Our data provide important insights into the mechanisms by which Neuroligin-4-dependent GABAergic synapses may contribute to autism phenotypes and indicate new strategies for therapeutic approaches."}],"author":[{"first_name":"Matthieu","last_name":"Hammer","full_name":"Hammer, Matthieu"},{"last_name":"Krueger Burg","full_name":"Krueger Burg, Dilja","first_name":"Dilja"},{"last_name":"Tuffy","full_name":"Tuffy, Liam","first_name":"Liam"},{"last_name":"Cooper","full_name":"Cooper, Benjamin","first_name":"Benjamin"},{"full_name":"Taschenberger, Holger","last_name":"Taschenberger","first_name":"Holger"},{"id":"3A578F32-F248-11E8-B48F-1D18A9856A87","last_name":"Goswami","full_name":"Goswami, Sarit","first_name":"Sarit"},{"first_name":"Hannelore","full_name":"Ehrenreich, Hannelore","last_name":"Ehrenreich"},{"last_name":"Jonas","full_name":"Jonas, Peter M","orcid":"0000-0001-5001-4804","first_name":"Peter M","id":"353C1B58-F248-11E8-B48F-1D18A9856A87"},{"first_name":"Frederique","full_name":"Varoqueaux, Frederique","last_name":"Varoqueaux"},{"last_name":"Rhee","full_name":"Rhee, Jeong","first_name":"Jeong"},{"first_name":"Nils","full_name":"Brose, Nils","last_name":"Brose"}],"publication_status":"published","citation":{"chicago":"Hammer, Matthieu, Dilja Krueger Burg, Liam Tuffy, Benjamin Cooper, Holger Taschenberger, Sarit Goswami, Hannelore Ehrenreich, et al. “Perturbed Hippocampal Synaptic Inhibition and γ-Oscillations in a Neuroligin-4 Knockout Mouse Model of Autism.” <i>Cell Reports</i>. Cell Press, 2015. <a href=\"https://doi.org/10.1016/j.celrep.2015.09.011\">https://doi.org/10.1016/j.celrep.2015.09.011</a>.","ieee":"M. Hammer <i>et al.</i>, “Perturbed hippocampal synaptic inhibition and γ-oscillations in a neuroligin-4 knockout mouse model of autism,” <i>Cell Reports</i>, vol. 13, no. 3. Cell Press, pp. 516–523, 2015.","apa":"Hammer, M., Krueger Burg, D., Tuffy, L., Cooper, B., Taschenberger, H., Goswami, S., … Brose, N. (2015). Perturbed hippocampal synaptic inhibition and γ-oscillations in a neuroligin-4 knockout mouse model of autism. <i>Cell Reports</i>. Cell Press. <a href=\"https://doi.org/10.1016/j.celrep.2015.09.011\">https://doi.org/10.1016/j.celrep.2015.09.011</a>","ista":"Hammer M, Krueger Burg D, Tuffy L, Cooper B, Taschenberger H, Goswami S, Ehrenreich H, Jonas PM, Varoqueaux F, Rhee J, Brose N. 2015. Perturbed hippocampal synaptic inhibition and γ-oscillations in a neuroligin-4 knockout mouse model of autism. Cell Reports. 13(3), 516–523.","short":"M. Hammer, D. Krueger Burg, L. Tuffy, B. Cooper, H. Taschenberger, S. Goswami, H. Ehrenreich, P.M. Jonas, F. Varoqueaux, J. Rhee, N. Brose, Cell Reports 13 (2015) 516–523.","ama":"Hammer M, Krueger Burg D, Tuffy L, et al. Perturbed hippocampal synaptic inhibition and γ-oscillations in a neuroligin-4 knockout mouse model of autism. <i>Cell Reports</i>. 2015;13(3):516-523. doi:<a href=\"https://doi.org/10.1016/j.celrep.2015.09.011\">10.1016/j.celrep.2015.09.011</a>","mla":"Hammer, Matthieu, et al. “Perturbed Hippocampal Synaptic Inhibition and γ-Oscillations in a Neuroligin-4 Knockout Mouse Model of Autism.” <i>Cell Reports</i>, vol. 13, no. 3, Cell Press, 2015, pp. 516–23, doi:<a href=\"https://doi.org/10.1016/j.celrep.2015.09.011\">10.1016/j.celrep.2015.09.011</a>."},"file":[{"content_type":"application/pdf","relation":"main_file","file_id":"5005","creator":"system","file_name":"IST-2016-470-v1+1_1-s2.0-S2211124715010220-main.pdf","file_size":2314406,"date_created":"2018-12-12T10:13:23Z","checksum":"44d30fbb543774b076b4938bd36af9d7","date_updated":"2020-07-14T12:45:07Z","access_level":"open_access"}],"date_created":"2018-12-11T11:53:02Z","has_accepted_license":"1","department":[{"_id":"PeJo"}],"publisher":"Cell Press","scopus_import":1,"language":[{"iso":"eng"}],"month":"10","date_published":"2015-10-20T00:00:00Z","issue":"3","publication":"Cell Reports","file_date_updated":"2020-07-14T12:45:07Z","page":"516 - 523","intvolume":"        13","status":"public","day":"20","type":"journal_article"},{"publist_id":"3774","date_updated":"2021-01-12T07:40:01Z","oa":1,"volume":103,"quality_controlled":"1","oa_version":"Submitted Version","project":[{"grant_number":"SFB-TR3-TP10B","_id":"25BDE9A4-B435-11E9-9278-68D0E5697425","name":"Glutamaterge synaptische Übertragung und Plastizität in hippocampalen Mikroschaltkreisen"}],"acknowledgement":"This work was supported by the Deutsche Forschungsgemeinschaft (TR3/B10) and a European Research Council Advanced grant to P.J.\r\nWe thank H. Hu, S. J. Guzman, and C. Schmidt-Hieber for critically reading the manuscript, I. Koeva and F. Marr for technical support, and E. Kramberger for editorial assistance.\r\n","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","pmid":1,"_id":"2954","citation":{"apa":"Pernia-Andrade, A., Goswami, S., Stickler, Y., Fröbe, U., Schlögl, A., &#38; Jonas, P. M. (2012). A deconvolution based method with high sensitivity and temporal resolution for detection of spontaneous synaptic currents in vitro and in vivo. <i>Biophysical Journal</i>. Biophysical. <a href=\"https://doi.org/10.1016/j.bpj.2012.08.039\">https://doi.org/10.1016/j.bpj.2012.08.039</a>","ieee":"A. Pernia-Andrade, S. Goswami, Y. Stickler, U. Fröbe, A. Schlögl, and P. M. Jonas, “A deconvolution based method with high sensitivity and temporal resolution for detection of spontaneous synaptic currents in vitro and in vivo,” <i>Biophysical Journal</i>, vol. 103, no. 7. Biophysical, pp. 1429–1439, 2012.","chicago":"Pernia-Andrade, Alejandro, Sarit Goswami, Yvonne Stickler, Ulrich Fröbe, Alois Schlögl, and Peter M Jonas. “A Deconvolution Based Method with High Sensitivity and Temporal Resolution for Detection of Spontaneous Synaptic Currents in Vitro and in Vivo.” <i>Biophysical Journal</i>. Biophysical, 2012. <a href=\"https://doi.org/10.1016/j.bpj.2012.08.039\">https://doi.org/10.1016/j.bpj.2012.08.039</a>.","mla":"Pernia-Andrade, Alejandro, et al. “A Deconvolution Based Method with High Sensitivity and Temporal Resolution for Detection of Spontaneous Synaptic Currents in Vitro and in Vivo.” <i>Biophysical Journal</i>, vol. 103, no. 7, Biophysical, 2012, pp. 1429–39, doi:<a href=\"https://doi.org/10.1016/j.bpj.2012.08.039\">10.1016/j.bpj.2012.08.039</a>.","ama":"Pernia-Andrade A, Goswami S, Stickler Y, Fröbe U, Schlögl A, Jonas PM. A deconvolution based method with high sensitivity and temporal resolution for detection of spontaneous synaptic currents in vitro and in vivo. <i>Biophysical Journal</i>. 2012;103(7):1429-1439. doi:<a href=\"https://doi.org/10.1016/j.bpj.2012.08.039\">10.1016/j.bpj.2012.08.039</a>","short":"A. Pernia-Andrade, S. Goswami, Y. Stickler, U. Fröbe, A. Schlögl, P.M. Jonas, Biophysical Journal 103 (2012) 1429–1439.","ista":"Pernia-Andrade A, Goswami S, Stickler Y, Fröbe U, Schlögl A, Jonas PM. 2012. A deconvolution based method with high sensitivity and temporal resolution for detection of spontaneous synaptic currents in vitro and in vivo. Biophysical Journal. 103(7), 1429–1439."},"publication_status":"published","author":[{"full_name":"Pernia-Andrade, Alejandro","last_name":"Pernia-Andrade","first_name":"Alejandro","id":"36963E98-F248-11E8-B48F-1D18A9856A87"},{"first_name":"Sarit","last_name":"Goswami","full_name":"Goswami, Sarit","id":"3A578F32-F248-11E8-B48F-1D18A9856A87"},{"first_name":"Yvonne","full_name":"Stickler, Yvonne","last_name":"Stickler","id":"63B76600-E9CC-11E9-9B5F-82450873F7A1"},{"first_name":"Ulrich","full_name":"Fröbe, Ulrich","last_name":"Fröbe"},{"id":"45BF87EE-F248-11E8-B48F-1D18A9856A87","first_name":"Alois","orcid":"0000-0002-5621-8100","last_name":"Schlögl","full_name":"Schlögl, Alois"},{"last_name":"Jonas","full_name":"Jonas, Peter M","orcid":"0000-0001-5001-4804","first_name":"Peter M","id":"353C1B58-F248-11E8-B48F-1D18A9856A87"}],"abstract":[{"lang":"eng","text":"Spontaneous postsynaptic currents (PSCs) provide key information about the mechanisms of synaptic transmission and the activity modes of neuronal networks. However, detecting spontaneous PSCs in vitro and in vivo has been challenging, because of the small amplitude, the variable kinetics, and the undefined time of generation of these events. Here, we describe a, to our knowledge, new method for detecting spontaneous synaptic events by deconvolution, using a template that approximates the average time course of spontaneous PSCs. A recorded PSC trace is deconvolved from the template, resulting in a series of delta-like functions. The maxima of these delta-like events are reliably detected, revealing the precise onset times of the spontaneous PSCs. Among all detection methods, the deconvolution-based method has a unique temporal resolution, allowing the detection of individual events in high-frequency bursts. Furthermore, the deconvolution-based method has a high amplitude resolution, because deconvolution can substantially increase the signal/noise ratio. When tested against previously published methods using experimental data, the deconvolution-based method was superior for spontaneous PSCs recorded in vivo. Using the high-resolution deconvolution-based detection algorithm, we show that the frequency of spontaneous excitatory postsynaptic currents in dentate gyrus granule cells is 4.5 times higher in vivo than in vitro."}],"main_file_link":[{"url":"http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3471482/","open_access":"1"}],"doi":"10.1016/j.bpj.2012.08.039","year":"2012","external_id":{"pmid":["23062335"]},"title":"A deconvolution based method with high sensitivity and temporal resolution for detection of spontaneous synaptic currents in vitro and in vivo","page":"1429 - 1439","publication":"Biophysical Journal","issue":"7","type":"journal_article","day":"03","status":"public","intvolume":"       103","department":[{"_id":"PeJo"},{"_id":"ScienComp"}],"date_created":"2018-12-11T12:00:32Z","date_published":"2012-10-03T00:00:00Z","month":"10","language":[{"iso":"eng"}],"scopus_import":1,"publisher":"Biophysical"},{"publication_status":"published","citation":{"chicago":"Goswami, Sarit, Iancu Bucurenciu, and Peter M Jonas. “Miniature IPSCs in Hippocampal Granule Cells Are Triggered by Voltage-Gated Ca^(2+) Channels via Microdomain Coupling.” <i>Journal of Neuroscience</i>. Society for Neuroscience, 2012. <a href=\"https://doi.org/10.1523/JNEUROSCI.6104-11.2012\">https://doi.org/10.1523/JNEUROSCI.6104-11.2012</a>.","ieee":"S. Goswami, I. Bucurenciu, and P. M. Jonas, “Miniature IPSCs in hippocampal granule cells are triggered by voltage-gated Ca^(2+) channels via microdomain coupling,” <i>Journal of Neuroscience</i>, vol. 32, no. 41. Society for Neuroscience, pp. 14294–14304, 2012.","apa":"Goswami, S., Bucurenciu, I., &#38; Jonas, P. M. (2012). Miniature IPSCs in hippocampal granule cells are triggered by voltage-gated Ca^(2+) channels via microdomain coupling. <i>Journal of Neuroscience</i>. Society for Neuroscience. <a href=\"https://doi.org/10.1523/JNEUROSCI.6104-11.2012\">https://doi.org/10.1523/JNEUROSCI.6104-11.2012</a>","short":"S. Goswami, I. Bucurenciu, P.M. Jonas, Journal of Neuroscience 32 (2012) 14294–14304.","ista":"Goswami S, Bucurenciu I, Jonas PM. 2012. Miniature IPSCs in hippocampal granule cells are triggered by voltage-gated Ca^(2+) channels via microdomain coupling. Journal of Neuroscience. 32(41), 14294–14304.","mla":"Goswami, Sarit, et al. “Miniature IPSCs in Hippocampal Granule Cells Are Triggered by Voltage-Gated Ca^(2+) Channels via Microdomain Coupling.” <i>Journal of Neuroscience</i>, vol. 32, no. 41, Society for Neuroscience, 2012, pp. 14294–304, doi:<a href=\"https://doi.org/10.1523/JNEUROSCI.6104-11.2012\">10.1523/JNEUROSCI.6104-11.2012</a>.","ama":"Goswami S, Bucurenciu I, Jonas PM. Miniature IPSCs in hippocampal granule cells are triggered by voltage-gated Ca^(2+) channels via microdomain coupling. <i>Journal of Neuroscience</i>. 2012;32(41):14294-14304. doi:<a href=\"https://doi.org/10.1523/JNEUROSCI.6104-11.2012\">10.1523/JNEUROSCI.6104-11.2012</a>"},"author":[{"first_name":"Sarit","full_name":"Goswami, Sarit","last_name":"Goswami","id":"3A578F32-F248-11E8-B48F-1D18A9856A87"},{"last_name":"Bucurenciu","full_name":"Bucurenciu, Iancu","first_name":"Iancu"},{"id":"353C1B58-F248-11E8-B48F-1D18A9856A87","full_name":"Jonas, Peter M","last_name":"Jonas","orcid":"0000-0001-5001-4804","first_name":"Peter M"}],"abstract":[{"text":"The coupling between presynaptic Ca^(2+) channels and Ca^(2+) sensors of exocytosis is a key determinant of synaptic transmission. Evoked release from parvalbumin (PV)-expressing interneurons is triggered by nanodomain coupling of P/Q-type Ca^(2+) channels, whereas release from cholecystokinin (CCK)-containing interneurons is generated by microdomain coupling of N-type channels. Nanodomain coupling has several functional advantages, including speed and efficacy of transmission. One potential disadvantage is that stochastic\r\nopening of presynaptic Ca^(2+) channels may trigger spontaneous transmitter release. We addressed this possibility in rat hippocampal\r\ngranule cells, which receive converging inputs from different inhibitory sources. Both reduction of extracellular Ca^(2+) concentration and the unselective Ca^(2+) channel blocker Cd^(2+) reduced the frequency of miniature IPSCs (mIPSCs) in granule cells by ~50%, suggesting that the opening of presynaptic Ca^(2+) channels contributes to spontaneous release. Application of the selective P/Q-type Ca^(2+) channel blocker\r\nω-agatoxin IVa had no detectable effects, whereas both the N-type blocker ω-conotoxin GVIa and the L-type blocker nimodipine reduced\r\nmIPSC frequency. Furthermore, both the fast Ca^(2+) chelator BAPTA-AM and the slow chelator EGTA-AM reduced the mIPSC frequency,\r\nsuggesting that Ca^(2+)-dependent spontaneous release is triggered by microdomain rather than nanodomain coupling. The CB_(1) receptor\r\nagonist WIN 55212-2 also decreased spontaneous release; this effect was occluded by prior application of ω-conotoxin GVIa, suggesting that a major fraction of Ca^(2+)-dependent spontaneous release was generated at the terminals of CCK-expressing interneurons. Tonic inhibition generated by spontaneous opening of presynaptic N- and L-type Ca^(2+) channels may be important for hippocampal information processing.\r\n","lang":"eng"}],"publist_id":"3744","oa":1,"date_updated":"2021-01-12T07:40:08Z","volume":32,"acknowledgement":"This work was supported by grants from the Deutsche Forschungsgemeinschaft (TR 3/B10, Leibniz program, GSC-4 Spemann Graduate School) and the European Union (European Research Council Advanced Grant).","user_id":"3E5EF7F0-F248-11E8-B48F-1D18A9856A87","oa_version":"Submitted Version","project":[{"_id":"25BDE9A4-B435-11E9-9278-68D0E5697425","name":"Glutamaterge synaptische Übertragung und Plastizität in hippocampalen Mikroschaltkreisen","grant_number":"SFB-TR3-TP10B"}],"quality_controlled":"1","_id":"2969","pmid":1,"year":"2012","doi":"10.1523/JNEUROSCI.6104-11.2012","title":"Miniature IPSCs in hippocampal granule cells are triggered by voltage-gated Ca^(2+) channels via microdomain coupling","external_id":{"pmid":["23055500"]},"main_file_link":[{"url":"http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3632771/","open_access":"1"}],"type":"journal_article","day":"10","status":"public","intvolume":"        32","page":"14294 - 14304","issue":"41","publication":"Journal of Neuroscience","date_published":"2012-10-10T00:00:00Z","month":"10","language":[{"iso":"eng"}],"publisher":"Society for Neuroscience","scopus_import":1,"department":[{"_id":"PeJo"}],"date_created":"2018-12-11T12:00:36Z"},{"has_accepted_license":"1","department":[{"_id":"PeJo"}],"file":[{"file_id":"4931","creator":"system","content_type":"application/pdf","relation":"main_file","date_updated":"2020-07-14T12:46:07Z","access_level":"open_access","date_created":"2018-12-12T10:12:13Z","checksum":"4c1c86b2f6e4e1562f5bb800b457ea9f","file_name":"IST-2017-820-v1+1_17463_3_art_file_109404_ltmxbw.pdf","file_size":314246},{"date_created":"2018-12-12T10:12:14Z","checksum":"bceb2efdd49d115f4dde8486bc1be3f2","file_name":"IST-2017-820-v1+2_17463_3_figure_109402_ltmwlp.pdf","file_size":1840216,"date_updated":"2020-07-14T12:46:07Z","access_level":"open_access","file_id":"4932","creator":"system","content_type":"application/pdf","relation":"main_file"}],"date_created":"2018-12-11T12:02:38Z","month":"01","date_published":"2012-01-01T00:00:00Z","publisher":"Nature Publishing Group","scopus_import":1,"language":[{"iso":"eng"}],"issue":"1","publication":"Nature Reviews Neuroscience","page":"7 - 21","file_date_updated":"2020-07-14T12:46:07Z","day":"01","type":"journal_article","intvolume":"        13","status":"public","ddc":["570"],"doi":"10.1038/nrn3125","year":"2012","pubrep_id":"820","title":"Nanodomain coupling between Ca(2+) channels and sensors of exocytosis at fast mammalian synapses","oa":1,"date_updated":"2021-01-12T07:42:36Z","publist_id":"3322","volume":13,"_id":"3317","acknowledgement":"Work of the authors was funded by grants of the Deutsche Forschungsgemeinschaft to P.J. (grants SFB 780/A5, TR 3/B10 and the Leibniz programme), a European Research Council Advanced grant to P.J. and a Swiss National Foundation fellowship to E.E.\r\nWe thank D. Tsien and E. Neher for their comments on this Review, J. Guzmán and A. Pernía-Andrade for reading earlier versions and E. Kramberger for perfect editorial support. We apologize that owing to space constraints, not all relevant papers could be cited.\r\n","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","quality_controlled":"1","oa_version":"Submitted Version","project":[{"name":"Synaptic Mechanisms of Neuronal Network Function","_id":"25BC64A8-B435-11E9-9278-68D0E5697425","grant_number":"JO_780/A5"},{"grant_number":"SFB-TR3-TP10B","name":"Glutamaterge synaptische Übertragung und Plastizität in hippocampalen Mikroschaltkreisen","_id":"25BDE9A4-B435-11E9-9278-68D0E5697425"}],"publication_status":"published","citation":{"ista":"Eggermann E, Bucurenciu I, Goswami S, Jonas PM. 2012. Nanodomain coupling between Ca(2+) channels and sensors of exocytosis at fast mammalian synapses. Nature Reviews Neuroscience. 13(1), 7–21.","short":"E. Eggermann, I. Bucurenciu, S. Goswami, P.M. Jonas, Nature Reviews Neuroscience 13 (2012) 7–21.","mla":"Eggermann, Emmanuel, et al. “Nanodomain Coupling between Ca(2+) Channels and Sensors of Exocytosis at Fast Mammalian Synapses.” <i>Nature Reviews Neuroscience</i>, vol. 13, no. 1, Nature Publishing Group, 2012, pp. 7–21, doi:<a href=\"https://doi.org/10.1038/nrn3125\">10.1038/nrn3125</a>.","ama":"Eggermann E, Bucurenciu I, Goswami S, Jonas PM. Nanodomain coupling between Ca(2+) channels and sensors of exocytosis at fast mammalian synapses. <i>Nature Reviews Neuroscience</i>. 2012;13(1):7-21. doi:<a href=\"https://doi.org/10.1038/nrn3125\">10.1038/nrn3125</a>","chicago":"Eggermann, Emmanuel, Iancu Bucurenciu, Sarit Goswami, and Peter M Jonas. “Nanodomain Coupling between Ca(2+) Channels and Sensors of Exocytosis at Fast Mammalian Synapses.” <i>Nature Reviews Neuroscience</i>. Nature Publishing Group, 2012. <a href=\"https://doi.org/10.1038/nrn3125\">https://doi.org/10.1038/nrn3125</a>.","ieee":"E. Eggermann, I. Bucurenciu, S. Goswami, and P. M. Jonas, “Nanodomain coupling between Ca(2+) channels and sensors of exocytosis at fast mammalian synapses,” <i>Nature Reviews Neuroscience</i>, vol. 13, no. 1. Nature Publishing Group, pp. 7–21, 2012.","apa":"Eggermann, E., Bucurenciu, I., Goswami, S., &#38; Jonas, P. M. (2012). Nanodomain coupling between Ca(2+) channels and sensors of exocytosis at fast mammalian synapses. <i>Nature Reviews Neuroscience</i>. Nature Publishing Group. <a href=\"https://doi.org/10.1038/nrn3125\">https://doi.org/10.1038/nrn3125</a>"},"abstract":[{"text":"The physical distance between presynaptic Ca2+ channels and the Ca2+ sensors that trigger exocytosis of neurotransmitter-containing vesicles is a key determinant of the signalling properties of synapses in the nervous system. Recent functional analysis indicates that in some fast central synapses, transmitter release is triggered by a small number of Ca2+ channels that are coupled to Ca2+ sensors at the nanometre scale. Molecular analysis suggests that this tight coupling is generated by protein–protein interactions involving Ca2+ channels, Ca2+ sensors and various other synaptic proteins. Nanodomain coupling has several functional advantages, as it increases the efficacy, speed and energy efficiency of synaptic transmission.","lang":"eng"}],"author":[{"last_name":"Eggermann","full_name":"Eggermann, Emmanuel","first_name":"Emmanuel","id":"34DACA34-E9AE-11E9-849C-D35BD8ADC20C"},{"id":"4BD1D872-E9AE-11E9-9EE9-8BF4597A9E2A","first_name":"Iancu","full_name":"Bucurenciu, Iancu","last_name":"Bucurenciu"},{"first_name":"Sarit","full_name":"Goswami, Sarit","last_name":"Goswami","id":"3A578F32-F248-11E8-B48F-1D18A9856A87"},{"orcid":"0000-0001-5001-4804","full_name":"Jonas, Peter M","last_name":"Jonas","first_name":"Peter M","id":"353C1B58-F248-11E8-B48F-1D18A9856A87"}]},{"abstract":[{"lang":"eng","text":"Olfactory responses of Drosophila undergo pronounced changes after eclosion. The flies develop attraction to odors to which they are exposed and aversion to other odors. Behavioral adaptation is correlated with changes in the firing pattern of olfactory receptor neurons (ORNs). In this article, we present an information-theoretic analysis of the firing pattern of ORNs. Flies reared in a synthetic odorless medium were transferred after eclosion to three different media: (i) a synthetic medium relatively devoid of odor cues, (ii) synthetic medium infused with a single odorant, and (iii) complex cornmeal medium rich in odors. Recordings were made from an identified sensillum (type II), and the Jensen-Shannon divergence (D(JS)) was used to assess quantitatively the differences between ensemble spike responses to different odors. Analysis shows that prolonged exposure to ethyl acetate and several related esters increases sensitivity to these esters but does not improve the ability of the fly to distinguish between them. Flies exposed to cornmeal display varied sensitivity to these odorants and at the same time develop greater capacity to distinguish between odors. Deprivation of odor experience on an odorless synthetic medium leads to a loss of both sensitivity and acuity. Rich olfactory experience thus helps to shape the ORNs response and enhances its discriminative power. The experiments presented here demonstrate an experience-dependent adaptation at the level of the receptor neuron."}],"intvolume":"       107","status":"public","author":[{"first_name":"Atulya","last_name":"Iyengar","full_name":"Iyengar, Atulya"},{"full_name":"Chakraborty Tuhin, Subhra","last_name":"Chakraborty Tuhin","first_name":"Subhra"},{"id":"3A578F32-F248-11E8-B48F-1D18A9856A87","first_name":"Sarit","last_name":"Goswami","full_name":"Sarit Goswami"},{"first_name":"Chun","full_name":"Wu, Chun Fang","last_name":"Wu"},{"first_name":"Obaid","last_name":"Siddiqi","full_name":"Siddiqi, Obaid"}],"citation":{"ama":"Iyengar A, Chakraborty Tuhin S, Goswami S, Wu C, Siddiqi O. Post eclosion odor experience modifies olfactory receptor neuron coding in Drosophila. <i>PNAS</i>. 2010;107(21):9855-9860. doi:<a href=\"https://doi.org/10.1073/pnas.1003856107\">10.1073/pnas.1003856107</a>","mla":"Iyengar, Atulya, et al. “Post Eclosion Odor Experience Modifies Olfactory Receptor Neuron Coding in Drosophila.” <i>PNAS</i>, vol. 107, no. 21, National Academy of Sciences, 2010, pp. 9855–60, doi:<a href=\"https://doi.org/10.1073/pnas.1003856107\">10.1073/pnas.1003856107</a>.","short":"A. Iyengar, S. Chakraborty Tuhin, S. Goswami, C. Wu, O. Siddiqi, PNAS 107 (2010) 9855–60.","ista":"Iyengar A, Chakraborty Tuhin S, Goswami S, Wu C, Siddiqi O. 2010. Post eclosion odor experience modifies olfactory receptor neuron coding in Drosophila. PNAS. 107(21), 9855–60.","ieee":"A. Iyengar, S. Chakraborty Tuhin, S. Goswami, C. Wu, and O. Siddiqi, “Post eclosion odor experience modifies olfactory receptor neuron coding in Drosophila,” <i>PNAS</i>, vol. 107, no. 21. National Academy of Sciences, pp. 9855–60, 2010.","apa":"Iyengar, A., Chakraborty Tuhin, S., Goswami, S., Wu, C., &#38; Siddiqi, O. (2010). Post eclosion odor experience modifies olfactory receptor neuron coding in Drosophila. <i>PNAS</i>. National Academy of Sciences. <a href=\"https://doi.org/10.1073/pnas.1003856107\">https://doi.org/10.1073/pnas.1003856107</a>","chicago":"Iyengar, Atulya, Subhra Chakraborty Tuhin, Sarit Goswami, Chun Wu, and Obaid Siddiqi. “Post Eclosion Odor Experience Modifies Olfactory Receptor Neuron Coding in Drosophila.” <i>PNAS</i>. National Academy of Sciences, 2010. <a href=\"https://doi.org/10.1073/pnas.1003856107\">https://doi.org/10.1073/pnas.1003856107</a>."},"day":"01","publication_status":"published","type":"journal_article","extern":1,"_id":"3294","quality_controlled":0,"publication":"PNAS","issue":"21","page":"9855 - 60","volume":107,"date_updated":"2021-01-12T07:42:27Z","publist_id":"3347","title":"Post eclosion odor experience modifies olfactory receptor neuron coding in Drosophila","publisher":"National Academy of Sciences","year":"2010","month":"01","doi":"10.1073/pnas.1003856107","date_published":"2010-01-01T00:00:00Z","date_created":"2018-12-11T12:02:31Z"},{"intvolume":"        23","abstract":[{"text":"Chemotactic responses of Drosophila to certain esters and alcohols are experience dependent. When the flies are exposed after eclosion to these chemicals, the odorants become strongly attractive. We show that behavioral conditioning is accompanied by an increase in the electrophysiological responses of single neurons in sensilla basiconica. Sensitization involves odorants that act on a common olfactory receptor. The possible mechanism of imaginal conditioning and its ecological and evolutionary significance are discussed.","lang":"eng"}],"author":[{"first_name":"Subhra","last_name":"Chakraborty Tuhin","full_name":"Chakraborty Tuhin, Subhra"},{"first_name":"Sarit","full_name":"Sarit Goswami","last_name":"Goswami","id":"3A578F32-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Siddiqi, Obaid","last_name":"Siddiqi","first_name":"Obaid"}],"status":"public","citation":{"mla":"Chakraborty Tuhin, Subhra, et al. “Sensory Correlates of Imaginal Conditioning in Drosophila Melanogaster.” <i>Journal of Neurogenetics</i>, vol. 23, no. 1–2, Informa Healthcare, 2009, pp. 210–19, doi:<a href=\"https://doi.org/10.1080/01677060802491559 \">10.1080/01677060802491559 </a>.","ama":"Chakraborty Tuhin S, Goswami S, Siddiqi O. Sensory correlates of imaginal conditioning in Drosophila melanogaster. <i>Journal of Neurogenetics</i>. 2009;23(1-2):210-219. doi:<a href=\"https://doi.org/10.1080/01677060802491559 \">10.1080/01677060802491559 </a>","ista":"Chakraborty Tuhin S, Goswami S, Siddiqi O. 2009. Sensory correlates of imaginal conditioning in Drosophila melanogaster. Journal of Neurogenetics. 23(1–2), 210–9.","short":"S. Chakraborty Tuhin, S. Goswami, O. Siddiqi, Journal of Neurogenetics 23 (2009) 210–9.","apa":"Chakraborty Tuhin, S., Goswami, S., &#38; Siddiqi, O. (2009). Sensory correlates of imaginal conditioning in Drosophila melanogaster. <i>Journal of Neurogenetics</i>. Informa Healthcare. <a href=\"https://doi.org/10.1080/01677060802491559 \">https://doi.org/10.1080/01677060802491559 </a>","ieee":"S. Chakraborty Tuhin, S. Goswami, and O. Siddiqi, “Sensory correlates of imaginal conditioning in Drosophila melanogaster,” <i>Journal of Neurogenetics</i>, vol. 23, no. 1–2. Informa Healthcare, pp. 210–9, 2009.","chicago":"Chakraborty Tuhin, Subhra, Sarit Goswami, and Obaid Siddiqi. “Sensory Correlates of Imaginal Conditioning in Drosophila Melanogaster.” <i>Journal of Neurogenetics</i>. Informa Healthcare, 2009. <a href=\"https://doi.org/10.1080/01677060802491559 \">https://doi.org/10.1080/01677060802491559 </a>."},"day":"01","publication_status":"published","type":"journal_article","extern":1,"_id":"3293","quality_controlled":0,"publication":"Journal of Neurogenetics","issue":"1-2","page":"210 - 9","volume":23,"publist_id":"3348","date_updated":"2021-01-12T07:42:27Z","title":"Sensory correlates of imaginal conditioning in Drosophila melanogaster","publisher":"Informa Healthcare","month":"01","doi":"10.1080/01677060802491559 ","year":"2009","date_published":"2009-01-01T00:00:00Z","date_created":"2018-12-11T12:02:30Z"}]