---
_id: '14484'
abstract:
- lang: eng
text: Intercellular signaling molecules, known as morphogens, act at a long range
in developing tissues to provide spatial information and control properties such
as cell fate and tissue growth. The production, transport, and removal of morphogens
shape their concentration profiles in time and space. Downstream signaling cascades
and gene regulatory networks within cells then convert the spatiotemporal morphogen
profiles into distinct cellular responses. Current challenges are to understand
the diverse molecular and cellular mechanisms underlying morphogen gradient formation,
as well as the logic of downstream regulatory circuits involved in morphogen interpretation.
This knowledge, combining experimental and theoretical results, is essential to
understand emerging properties of morphogen-controlled systems, such as robustness
and scaling.
acknowledgement: We are grateful to Zena Hadjivasiliou for comments on this article.
A.K. is supported by grants from the European Research Council under the European
Union (EU) Horizon 2020 research and innovation program (680037) and Horizon Europe
(101044579), and the Austrian Science Fund (F78) (Stem Cell Modulation). J.B. is
supported by the Francis Crick Institute, which receives its core funding from Cancer
Research UK (CC001051), the UK Medical Research Council (CC001051), and the Wellcome
Trust (CC001051), and by a grant from the European Research Council under the EU
Horizon 2020 research and innovation program (742138).
article_processing_charge: Yes (in subscription journal)
article_type: review
author:
- first_name: Anna
full_name: Kicheva, Anna
id: 3959A2A0-F248-11E8-B48F-1D18A9856A87
last_name: Kicheva
orcid: 0000-0003-4509-4998
- first_name: James
full_name: Briscoe, James
last_name: Briscoe
citation:
ama: Kicheva A, Briscoe J. Control of tissue development by morphogens. Annual
Review of Cell and Developmental Biology. 2023;39:91-121. doi:10.1146/annurev-cellbio-020823-011522
apa: Kicheva, A., & Briscoe, J. (2023). Control of tissue development by morphogens.
Annual Review of Cell and Developmental Biology. Annual Reviews. https://doi.org/10.1146/annurev-cellbio-020823-011522
chicago: Kicheva, Anna, and James Briscoe. “Control of Tissue Development by Morphogens.”
Annual Review of Cell and Developmental Biology. Annual Reviews, 2023.
https://doi.org/10.1146/annurev-cellbio-020823-011522.
ieee: A. Kicheva and J. Briscoe, “Control of tissue development by morphogens,”
Annual Review of Cell and Developmental Biology, vol. 39. Annual Reviews,
pp. 91–121, 2023.
ista: Kicheva A, Briscoe J. 2023. Control of tissue development by morphogens. Annual
Review of Cell and Developmental Biology. 39, 91–121.
mla: Kicheva, Anna, and James Briscoe. “Control of Tissue Development by Morphogens.”
Annual Review of Cell and Developmental Biology, vol. 39, Annual Reviews,
2023, pp. 91–121, doi:10.1146/annurev-cellbio-020823-011522.
short: A. Kicheva, J. Briscoe, Annual Review of Cell and Developmental Biology 39
(2023) 91–121.
date_created: 2023-11-05T23:00:53Z
date_published: 2023-10-16T00:00:00Z
date_updated: 2023-11-06T09:56:24Z
day: '16'
ddc:
- '570'
department:
- _id: AnKi
doi: 10.1146/annurev-cellbio-020823-011522
ec_funded: 1
external_id:
pmid:
- '37418774'
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creator: dernst
date_created: 2023-11-06T09:47:50Z
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oa_version: Published Version
page: 91-121
pmid: 1
project:
- _id: B6FC0238-B512-11E9-945C-1524E6697425
call_identifier: H2020
grant_number: '680037'
name: Coordination of Patterning And Growth In the Spinal Cord
- _id: bd7e737f-d553-11ed-ba76-d69ffb5ee3aa
grant_number: '101044579'
name: Mechanisms of tissue size regulation in spinal cord development
- _id: 059DF620-7A3F-11EA-A408-12923DDC885E
grant_number: F07802
name: Morphogen control of growth and pattern in the spinal cord
publication: Annual Review of Cell and Developmental Biology
publication_identifier:
eissn:
- 1530-8995
issn:
- 1081-0706
publication_status: published
publisher: Annual Reviews
quality_controlled: '1'
scopus_import: '1'
status: public
title: Control of tissue development by morphogens
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 39
year: '2023'
...
---
_id: '13136'
abstract:
- lang: eng
text: Despite its fundamental importance for development, the question of how organs
achieve their correct size and shape is poorly understood. This complex process
requires coordination between the generation of cell mass and the morphogenetic
mechanisms that sculpt tissues. These processes are regulated by morphogen signalling
pathways and mechanical forces. Yet, in many systems, it is unclear how biochemical
and mechanical signalling are quantitatively interpreted to determine the behaviours
of individual cells and how they contribute to growth and morphogenesis at the
tissue scale. In this review, we discuss the development of the vertebrate neural
tube and somites as an example of the state of knowledge, as well as the challenges
in understanding the mechanisms of tissue size control in vertebrate organogenesis.
We highlight how the recent advances in stem cell differentiation and organoid
approaches can be harnessed to provide new insights into this question.
acknowledgement: 'We thank J. Briscoe for comments on the manuscript. Work in the
AK lab is supported by ISTA, the European Research Council under Horizon Europe:
grant 101044579, and Austrian Science Fund (FWF): F78 (Stem Cell Modulation). SR
is supported by Gesellschaft für Forschungsförderung Niederösterreich m.b.H. fellowship
SC19-011.'
article_number: '100459'
article_processing_charge: Yes (via OA deal)
article_type: original
author:
- first_name: Thomas
full_name: Minchington, Thomas
id: 7d1648cb-19e9-11eb-8e7a-f8c037fb3e3f
last_name: Minchington
- first_name: Stefanie
full_name: Rus, Stefanie
id: 4D9EC9B6-F248-11E8-B48F-1D18A9856A87
last_name: Rus
orcid: 0000-0001-8703-1093
- first_name: Anna
full_name: Kicheva, Anna
id: 3959A2A0-F248-11E8-B48F-1D18A9856A87
last_name: Kicheva
orcid: 0000-0003-4509-4998
citation:
ama: Minchington T, Rus S, Kicheva A. Control of tissue dimensions in the developing
neural tube and somites. Current Opinion in Systems Biology. 2023;35. doi:10.1016/j.coisb.2023.100459
apa: Minchington, T., Rus, S., & Kicheva, A. (2023). Control of tissue dimensions
in the developing neural tube and somites. Current Opinion in Systems Biology.
Elsevier. https://doi.org/10.1016/j.coisb.2023.100459
chicago: Minchington, Thomas, Stefanie Rus, and Anna Kicheva. “Control of Tissue
Dimensions in the Developing Neural Tube and Somites.” Current Opinion in Systems
Biology. Elsevier, 2023. https://doi.org/10.1016/j.coisb.2023.100459.
ieee: T. Minchington, S. Rus, and A. Kicheva, “Control of tissue dimensions in the
developing neural tube and somites,” Current Opinion in Systems Biology,
vol. 35. Elsevier, 2023.
ista: Minchington T, Rus S, Kicheva A. 2023. Control of tissue dimensions in the
developing neural tube and somites. Current Opinion in Systems Biology. 35, 100459.
mla: Minchington, Thomas, et al. “Control of Tissue Dimensions in the Developing
Neural Tube and Somites.” Current Opinion in Systems Biology, vol. 35,
100459, Elsevier, 2023, doi:10.1016/j.coisb.2023.100459.
short: T. Minchington, S. Rus, A. Kicheva, Current Opinion in Systems Biology 35
(2023).
date_created: 2023-06-18T22:00:46Z
date_published: 2023-09-01T00:00:00Z
date_updated: 2024-01-29T11:07:47Z
day: '01'
ddc:
- '570'
department:
- _id: AnKi
doi: 10.1016/j.coisb.2023.100459
file:
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checksum: 8a75c4e29fd9b62e3c50663c2265b173
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creator: dernst
date_created: 2024-01-29T11:06:45Z
date_updated: 2024-01-29T11:06:45Z
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success: 1
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intvolume: ' 35'
language:
- iso: eng
month: '09'
oa: 1
oa_version: Published Version
project:
- _id: bd7e737f-d553-11ed-ba76-d69ffb5ee3aa
grant_number: '101044579'
name: Mechanisms of tissue size regulation in spinal cord development
- _id: 059DF620-7A3F-11EA-A408-12923DDC885E
grant_number: F07802
name: Morphogen control of growth and pattern in the spinal cord
- _id: 9B9B39FA-BA93-11EA-9121-9846C619BF3A
grant_number: SC19-011
name: The regulatory logic of pattern formation in the vertebrate dorsal neural
tube
publication: Current Opinion in Systems Biology
publication_identifier:
eissn:
- 2452-3100
publication_status: published
publisher: Elsevier
quality_controlled: '1'
scopus_import: '1'
status: public
title: Control of tissue dimensions in the developing neural tube and somites
tmp:
image: /images/cc_by_nc_nd.png
legal_code_url: https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode
name: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
(CC BY-NC-ND 4.0)
short: CC BY-NC-ND (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 35
year: '2023'
...
---
_id: '12837'
abstract:
- lang: eng
text: As developing tissues grow in size and undergo morphogenetic changes, their
material properties may be altered. Such changes result from tension dynamics
at cell contacts or cellular jamming. Yet, in many cases, the cellular mechanisms
controlling the physical state of growing tissues are unclear. We found that at
early developmental stages, the epithelium in the developing mouse spinal cord
maintains both high junctional tension and high fluidity. This is achieved via
a mechanism in which interkinetic nuclear movements generate cell area dynamics
that drive extensive cell rearrangements. Over time, the cell proliferation rate
declines, effectively solidifying the tissue. Thus, unlike well-studied jamming
transitions, the solidification uncovered here resembles a glass transition that
depends on the dynamical stresses generated by proliferation and differentiation.
Our finding that the fluidity of developing epithelia is linked to interkinetic
nuclear movements and the dynamics of growth is likely to be relevant to multiple
developing tissues.
acknowledgement: 'We thank S. Hippenmeyer for the reagents and C. P. Heisenberg, J.
Briscoe and K. Page for comments on the manuscript. This work was supported by IST
Austria; the European Research Council under Horizon 2020 research and innovation
programme grant no. 680037 and Horizon Europe grant 101044579 (A.K.); Austrian Science
Fund (FWF): F78 (Stem Cell Modulation) (A.K.); ISTFELLOW postdoctoral program (A.S.);
Narodowe Centrum Nauki, Poland SONATA, 2017/26/D/NZ2/00454 (M.Z.); and the Polish
National Agency for Academic Exchange (M.Z.).'
article_processing_charge: No
article_type: original
author:
- first_name: Laura
full_name: Bocanegra, Laura
id: 4896F754-F248-11E8-B48F-1D18A9856A87
last_name: Bocanegra
- first_name: Amrita
full_name: Singh, Amrita
id: 76250f9f-3a21-11eb-9a80-a6180a0d7958
last_name: Singh
- first_name: Edouard B
full_name: Hannezo, Edouard B
id: 3A9DB764-F248-11E8-B48F-1D18A9856A87
last_name: Hannezo
orcid: 0000-0001-6005-1561
- first_name: Marcin P
full_name: Zagórski, Marcin P
id: 343DA0DC-F248-11E8-B48F-1D18A9856A87
last_name: Zagórski
orcid: 0000-0001-7896-7762
- first_name: Anna
full_name: Kicheva, Anna
id: 3959A2A0-F248-11E8-B48F-1D18A9856A87
last_name: Kicheva
orcid: 0000-0003-4509-4998
citation:
ama: Bocanegra L, Singh A, Hannezo EB, Zagórski MP, Kicheva A. Cell cycle dynamics
control fluidity of the developing mouse neuroepithelium. Nature Physics.
2023;19:1050-1058. doi:10.1038/s41567-023-01977-w
apa: Bocanegra, L., Singh, A., Hannezo, E. B., Zagórski, M. P., & Kicheva, A.
(2023). Cell cycle dynamics control fluidity of the developing mouse neuroepithelium.
Nature Physics. Springer Nature. https://doi.org/10.1038/s41567-023-01977-w
chicago: Bocanegra, Laura, Amrita Singh, Edouard B Hannezo, Marcin P Zagórski, and
Anna Kicheva. “Cell Cycle Dynamics Control Fluidity of the Developing Mouse Neuroepithelium.”
Nature Physics. Springer Nature, 2023. https://doi.org/10.1038/s41567-023-01977-w.
ieee: L. Bocanegra, A. Singh, E. B. Hannezo, M. P. Zagórski, and A. Kicheva, “Cell
cycle dynamics control fluidity of the developing mouse neuroepithelium,” Nature
Physics, vol. 19. Springer Nature, pp. 1050–1058, 2023.
ista: Bocanegra L, Singh A, Hannezo EB, Zagórski MP, Kicheva A. 2023. Cell cycle
dynamics control fluidity of the developing mouse neuroepithelium. Nature Physics.
19, 1050–1058.
mla: Bocanegra, Laura, et al. “Cell Cycle Dynamics Control Fluidity of the Developing
Mouse Neuroepithelium.” Nature Physics, vol. 19, Springer Nature, 2023,
pp. 1050–58, doi:10.1038/s41567-023-01977-w.
short: L. Bocanegra, A. Singh, E.B. Hannezo, M.P. Zagórski, A. Kicheva, Nature Physics
19 (2023) 1050–1058.
date_created: 2023-04-16T22:01:09Z
date_published: 2023-07-01T00:00:00Z
date_updated: 2023-10-04T11:14:05Z
day: '01'
ddc:
- '570'
department:
- _id: EdHa
- _id: AnKi
doi: 10.1038/s41567-023-01977-w
ec_funded: 1
external_id:
isi:
- '000964029300003'
file:
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checksum: 858225a4205b74406e5045006cdd853f
content_type: application/pdf
creator: dernst
date_created: 2023-10-04T11:13:28Z
date_updated: 2023-10-04T11:13:28Z
file_id: '14392'
file_name: 2023_NaturePhysics_Boncanegra.pdf
file_size: 5532285
relation: main_file
success: 1
file_date_updated: 2023-10-04T11:13:28Z
has_accepted_license: '1'
intvolume: ' 19'
isi: 1
language:
- iso: eng
month: '07'
oa: 1
oa_version: Published Version
page: 1050-1058
project:
- _id: B6FC0238-B512-11E9-945C-1524E6697425
call_identifier: H2020
grant_number: '680037'
name: Coordination of Patterning And Growth In the Spinal Cord
- _id: bd7e737f-d553-11ed-ba76-d69ffb5ee3aa
grant_number: '101044579'
name: Mechanisms of tissue size regulation in spinal cord development
- _id: 059DF620-7A3F-11EA-A408-12923DDC885E
grant_number: F07802
name: Morphogen control of growth and pattern in the spinal cord
- _id: 25681D80-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '291734'
name: International IST Postdoc Fellowship Programme
publication: Nature Physics
publication_identifier:
eissn:
- 1745-2481
issn:
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publication_status: published
publisher: Springer Nature
quality_controlled: '1'
related_material:
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scopus_import: '1'
status: public
title: Cell cycle dynamics control fluidity of the developing mouse neuroepithelium
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 19
year: '2023'
...
---
_id: '7883'
abstract:
- lang: eng
text: All vertebrates have a spinal cord with dimensions and shape specific to their
species. Yet how species‐specific organ size and shape are achieved is a fundamental
unresolved question in biology. The formation and sculpting of organs begins during
embryonic development. As it develops, the spinal cord extends in anterior–posterior
direction in synchrony with the overall growth of the body. The dorsoventral (DV)
and apicobasal lengths of the spinal cord neuroepithelium also change, while at
the same time a characteristic pattern of neural progenitor subtypes along the
DV axis is established and elaborated. At the basis of these changes in tissue
size and shape are biophysical determinants, such as the change in cell number,
cell size and shape, and anisotropic tissue growth. These processes are controlled
by global tissue‐scale regulators, such as morphogen signaling gradients as well
as mechanical forces. Current challenges in the field are to uncover how these
tissue‐scale regulatory mechanisms are translated to the cellular and molecular
level, and how regulation of distinct cellular processes gives rise to an overall
defined size. Addressing these questions will help not only to achieve a better
understanding of how size is controlled, but also of how tissue size is coordinated
with the specification of pattern.
acknowledgement: 'Austrian Academy of Sciences, Grant/Award Number: DOC fellowship
for Katarzyna Kuzmicz-Kowalska; Austrian Science Fund, Grant/Award Number: F78 (Stem
Cell Modulation); H2020 European Research Council, Grant/Award Number: 680037'
article_number: e383
article_processing_charge: Yes (via OA deal)
article_type: original
author:
- first_name: Katarzyna
full_name: Kuzmicz-Kowalska, Katarzyna
id: 4CED352A-F248-11E8-B48F-1D18A9856A87
last_name: Kuzmicz-Kowalska
- first_name: Anna
full_name: Kicheva, Anna
id: 3959A2A0-F248-11E8-B48F-1D18A9856A87
last_name: Kicheva
orcid: 0000-0003-4509-4998
citation:
ama: 'Kuzmicz-Kowalska K, Kicheva A. Regulation of size and scale in vertebrate
spinal cord development. Wiley Interdisciplinary Reviews: Developmental Biology.
2021. doi:10.1002/wdev.383'
apa: 'Kuzmicz-Kowalska, K., & Kicheva, A. (2021). Regulation of size and scale
in vertebrate spinal cord development. Wiley Interdisciplinary Reviews: Developmental
Biology. Wiley. https://doi.org/10.1002/wdev.383'
chicago: 'Kuzmicz-Kowalska, Katarzyna, and Anna Kicheva. “Regulation of Size and
Scale in Vertebrate Spinal Cord Development.” Wiley Interdisciplinary Reviews:
Developmental Biology. Wiley, 2021. https://doi.org/10.1002/wdev.383.'
ieee: 'K. Kuzmicz-Kowalska and A. Kicheva, “Regulation of size and scale in vertebrate
spinal cord development,” Wiley Interdisciplinary Reviews: Developmental Biology.
Wiley, 2021.'
ista: 'Kuzmicz-Kowalska K, Kicheva A. 2021. Regulation of size and scale in vertebrate
spinal cord development. Wiley Interdisciplinary Reviews: Developmental Biology.,
e383.'
mla: 'Kuzmicz-Kowalska, Katarzyna, and Anna Kicheva. “Regulation of Size and Scale
in Vertebrate Spinal Cord Development.” Wiley Interdisciplinary Reviews: Developmental
Biology, e383, Wiley, 2021, doi:10.1002/wdev.383.'
short: 'K. Kuzmicz-Kowalska, A. Kicheva, Wiley Interdisciplinary Reviews: Developmental
Biology (2021).'
date_created: 2020-05-24T22:01:00Z
date_published: 2021-04-15T00:00:00Z
date_updated: 2024-03-07T15:03:00Z
day: '15'
ddc:
- '570'
department:
- _id: AnKi
doi: 10.1002/wdev.383
ec_funded: 1
external_id:
isi:
- '000531419400001'
pmid:
- '32391980'
file:
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checksum: f0a7745d48afa09ea7025e876a0145a8
content_type: application/pdf
creator: dernst
date_created: 2020-11-24T13:11:39Z
date_updated: 2020-11-24T13:11:39Z
file_id: '8800'
file_name: 2020_WIREs_DevBio_KuzmiczKowalska.pdf
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has_accepted_license: '1'
isi: 1
language:
- iso: eng
month: '04'
oa: 1
oa_version: Published Version
pmid: 1
project:
- _id: B6FC0238-B512-11E9-945C-1524E6697425
call_identifier: H2020
grant_number: '680037'
name: Coordination of Patterning And Growth In the Spinal Cord
- _id: 267AF0E4-B435-11E9-9278-68D0E5697425
name: The role of morphogens in the regulation of neural tube growth
- _id: 059DF620-7A3F-11EA-A408-12923DDC885E
grant_number: F07802
name: Morphogen control of growth and pattern in the spinal cord
publication: 'Wiley Interdisciplinary Reviews: Developmental Biology'
publication_identifier:
eissn:
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issn:
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publication_status: published
publisher: Wiley
quality_controlled: '1'
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status: public
title: Regulation of size and scale in vertebrate spinal cord development
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 3E5EF7F0-F248-11E8-B48F-1D18A9856A87
year: '2021'
...
---
_id: '9349'
abstract:
- lang: eng
text: 'The way in which interactions between mechanics and biochemistry lead to
the emergence of complex cell and tissue organization is an old question that
has recently attracted renewed interest from biologists, physicists, mathematicians
and computer scientists. Rapid advances in optical physics, microscopy and computational
image analysis have greatly enhanced our ability to observe and quantify spatiotemporal
patterns of signalling, force generation, deformation, and flow in living cells
and tissues. Powerful new tools for genetic, biophysical and optogenetic manipulation
are allowing us to perturb the underlying machinery that generates these patterns
in increasingly sophisticated ways. Rapid advances in theory and computing have
made it possible to construct predictive models that describe how cell and tissue
organization and dynamics emerge from the local coupling of biochemistry and mechanics.
Together, these advances have opened up a wealth of new opportunities to explore
how mechanochemical patterning shapes organismal development. In this roadmap,
we present a series of forward-looking case studies on mechanochemical patterning
in development, written by scientists working at the interface between the physical
and biological sciences, and covering a wide range of spatial and temporal scales,
organisms, and modes of development. Together, these contributions highlight the
many ways in which the dynamic coupling of mechanics and biochemistry shapes biological
dynamics: from mechanoenzymes that sense force to tune their activity and motor
output, to collectives of cells in tissues that flow and redistribute biochemical
signals during development.'
acknowledgement: The AK group is supported by IST Austria and by the ERC under European
Union Horizon 2020 research and innovation programme Grant 680037. Apologies to
those whose work could not be mentioned due to limited space. We thank all my lab
members, both past and present, for stimulating discussion. This work was funded
by a Singapore Ministry of Education Tier 3 Grant, MOE2016-T3-1-005. We thank Francis
Corson for continuous discussion and collaboration contributing to these views and
for figure 4(A). PC is sponsored by the Institut Pasteur and the European Union's
Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie
Grant Agreement No. 665807. Research in JG's laboratory is funded by the European
Research Council under the European Union's Seventh Framework Programme (FP7/2007-2013)/ERC
Grant Agreement No. 337635, Institut Pasteur, CNRS, Cercle FSER, Fondation pour
la Recherche Medicale, the Vallee Foundation and the ANR-19-CE-13-0024 Grant. We
thank Erez Braun and Alex Mogilner for comments on the manuscript and Niv Ierushalmi
for help with figure 5. This project has received funding from the European Union's
Horizon 2020 research and innovation programme under Grant Agreement No. ERC-2018-COG
Grant 819174-HydraMechanics awarded to KK. EH thanks all lab members, as well as
Pierre Recho, Tsuyoshi Hirashima, Diana Pinheiro and Carl-Philip Heisenberg, for
fruitful discussions on these topics—and apologize for not being able to cite many
very relevant publications due to the strict 10-reference limit. EH acknowledges
the support of Austrian Science Fund (FWF) (P 31639) and the European Research Council
under the European Union's Horizon 2020 Research and Innovation Programme Grant
Agreements (851288). The authors acknowledge the inspiring scientists whose work
could not be cited in this perspective due to space constraints; the members of
the Gartner Lab for helpful discussions; the Barbara and Gerson Bakar Foundation,
the Chan Zuckerberg Biohub Investigators Programme, the National Institute of Health,
and the Centre for Cellular Construction, an NSF Science and Technology Centre.
The Minc laboratory is currently funded by the CNRS and the European Research Council
(CoG Forcaster No. 647073). Research in the lab of J-LM is supported by the Institut
Curie, the Centre National de la Recherche Scientifique (CNRS), the Institut National
de la Santé Et de la Recherche Médicale (INSERM), and is funded by grants from the
ATIP-Avenir programme, the Fondation Schlumberger pour l'Éducation et la Recherche
via the Fondation pour la Recherche Médicale, the European Research Council Starting
Grant ERC-2017-StG 757557, the European Molecular Biology Organization Young Investigator
programme (EMBO YIP), the INSERM transversal programme Human Development Cell Atlas
(HuDeCA), Paris Sciences Lettres (PSL) 'nouvelle équipe' and QLife (17-CONV-0005)
grants and Labex DEEP (ANR-11-LABX-0044) which are part of the IDEX PSL (ANR-10-IDEX-0001-02).
We acknowledge useful discussions with Massimo Vergassola, Sebastian Streichan and
my lab members. Work in my laboratory on Drosophila embryogenesis is partly supported
by NIH-R01GM122936. The authors acknowledge the support by a grant from the European
Research Council (Grant No. 682161). Lenne group is funded by a grant from the 'Investissements
d'Avenir' French Government programme managed by the French National Research Agency
(ANR-16-CONV-0001) and by the Excellence Initiative of Aix-Marseille University—A*MIDEX,
and ANR projects MechaResp (ANR-17-CE13-0032) and AdGastrulo (ANR-19-CE13-0022).
article_number: '041501'
article_processing_charge: No
article_type: original
author:
- first_name: Pierre François
full_name: Lenne, Pierre François
last_name: Lenne
- first_name: Edwin
full_name: Munro, Edwin
last_name: Munro
- first_name: Idse
full_name: Heemskerk, Idse
last_name: Heemskerk
- first_name: Aryeh
full_name: Warmflash, Aryeh
last_name: Warmflash
- first_name: Laura
full_name: Bocanegra, Laura
id: 4896F754-F248-11E8-B48F-1D18A9856A87
last_name: Bocanegra
- first_name: Kasumi
full_name: Kishi, Kasumi
id: 3065DFC4-F248-11E8-B48F-1D18A9856A87
last_name: Kishi
- first_name: Anna
full_name: Kicheva, Anna
id: 3959A2A0-F248-11E8-B48F-1D18A9856A87
last_name: Kicheva
orcid: 0000-0003-4509-4998
- first_name: Yuchen
full_name: Long, Yuchen
last_name: Long
- first_name: Antoine
full_name: Fruleux, Antoine
last_name: Fruleux
- first_name: Arezki
full_name: Boudaoud, Arezki
last_name: Boudaoud
- first_name: Timothy E.
full_name: Saunders, Timothy E.
last_name: Saunders
- first_name: Paolo
full_name: Caldarelli, Paolo
last_name: Caldarelli
- first_name: Arthur
full_name: Michaut, Arthur
last_name: Michaut
- first_name: Jerome
full_name: Gros, Jerome
last_name: Gros
- first_name: Yonit
full_name: Maroudas-Sacks, Yonit
last_name: Maroudas-Sacks
- first_name: Kinneret
full_name: Keren, Kinneret
last_name: Keren
- first_name: Edouard B
full_name: Hannezo, Edouard B
id: 3A9DB764-F248-11E8-B48F-1D18A9856A87
last_name: Hannezo
orcid: 0000-0001-6005-1561
- first_name: Zev J.
full_name: Gartner, Zev J.
last_name: Gartner
- first_name: Benjamin
full_name: Stormo, Benjamin
last_name: Stormo
- first_name: Amy
full_name: Gladfelter, Amy
last_name: Gladfelter
- first_name: Alan
full_name: Rodrigues, Alan
last_name: Rodrigues
- first_name: Amy
full_name: Shyer, Amy
last_name: Shyer
- first_name: Nicolas
full_name: Minc, Nicolas
last_name: Minc
- first_name: Jean Léon
full_name: Maître, Jean Léon
last_name: Maître
- first_name: Stefano
full_name: Di Talia, Stefano
last_name: Di Talia
- first_name: Bassma
full_name: Khamaisi, Bassma
last_name: Khamaisi
- first_name: David
full_name: Sprinzak, David
last_name: Sprinzak
- first_name: Sham
full_name: Tlili, Sham
last_name: Tlili
citation:
ama: Lenne PF, Munro E, Heemskerk I, et al. Roadmap for the multiscale coupling
of biochemical and mechanical signals during development. Physical biology.
2021;18(4). doi:10.1088/1478-3975/abd0db
apa: Lenne, P. F., Munro, E., Heemskerk, I., Warmflash, A., Bocanegra, L., Kishi,
K., … Tlili, S. (2021). Roadmap for the multiscale coupling of biochemical and
mechanical signals during development. Physical Biology. IOP Publishing.
https://doi.org/10.1088/1478-3975/abd0db
chicago: Lenne, Pierre François, Edwin Munro, Idse Heemskerk, Aryeh Warmflash, Laura
Bocanegra, Kasumi Kishi, Anna Kicheva, et al. “Roadmap for the Multiscale Coupling
of Biochemical and Mechanical Signals during Development.” Physical Biology.
IOP Publishing, 2021. https://doi.org/10.1088/1478-3975/abd0db.
ieee: P. F. Lenne et al., “Roadmap for the multiscale coupling of biochemical
and mechanical signals during development,” Physical biology, vol. 18,
no. 4. IOP Publishing, 2021.
ista: Lenne PF, Munro E, Heemskerk I, Warmflash A, Bocanegra L, Kishi K, Kicheva
A, Long Y, Fruleux A, Boudaoud A, Saunders TE, Caldarelli P, Michaut A, Gros J,
Maroudas-Sacks Y, Keren K, Hannezo EB, Gartner ZJ, Stormo B, Gladfelter A, Rodrigues
A, Shyer A, Minc N, Maître JL, Di Talia S, Khamaisi B, Sprinzak D, Tlili S. 2021.
Roadmap for the multiscale coupling of biochemical and mechanical signals during
development. Physical biology. 18(4), 041501.
mla: Lenne, Pierre François, et al. “Roadmap for the Multiscale Coupling of Biochemical
and Mechanical Signals during Development.” Physical Biology, vol. 18,
no. 4, 041501, IOP Publishing, 2021, doi:10.1088/1478-3975/abd0db.
short: P.F. Lenne, E. Munro, I. Heemskerk, A. Warmflash, L. Bocanegra, K. Kishi,
A. Kicheva, Y. Long, A. Fruleux, A. Boudaoud, T.E. Saunders, P. Caldarelli, A.
Michaut, J. Gros, Y. Maroudas-Sacks, K. Keren, E.B. Hannezo, Z.J. Gartner, B.
Stormo, A. Gladfelter, A. Rodrigues, A. Shyer, N. Minc, J.L. Maître, S. Di Talia,
B. Khamaisi, D. Sprinzak, S. Tlili, Physical Biology 18 (2021).
date_created: 2021-04-25T22:01:29Z
date_published: 2021-04-14T00:00:00Z
date_updated: 2023-08-08T13:15:46Z
day: '14'
ddc:
- '570'
department:
- _id: AnKi
- _id: EdHa
doi: 10.1088/1478-3975/abd0db
ec_funded: 1
external_id:
isi:
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month: '04'
oa: 1
oa_version: Published Version
pmid: 1
project:
- _id: B6FC0238-B512-11E9-945C-1524E6697425
call_identifier: H2020
grant_number: '680037'
name: Coordination of Patterning And Growth In the Spinal Cord
- _id: 268294B6-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: P31639
name: Active mechano-chemical description of the cell cytoskeleton
- _id: 05943252-7A3F-11EA-A408-12923DDC885E
call_identifier: H2020
grant_number: '851288'
name: Design Principles of Branching Morphogenesis
publication: Physical biology
publication_identifier:
eissn:
- 1478-3975
publication_status: published
publisher: IOP Publishing
quality_controlled: '1'
related_material:
record:
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relation: dissertation_contains
status: public
scopus_import: '1'
status: public
title: Roadmap for the multiscale coupling of biochemical and mechanical signals during
development
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 18
year: '2021'
...
---
_id: '7165'
abstract:
- lang: eng
text: Cell division, movement and differentiation contribute to pattern formation
in developing tissues. This is the case in the vertebrate neural tube, in which
neurons differentiate in a characteristic pattern from a highly dynamic proliferating
pseudostratified epithelium. To investigate how progenitor proliferation and differentiation
affect cell arrangement and growth of the neural tube, we used experimental measurements
to develop a mechanical model of the apical surface of the neuroepithelium that
incorporates the effect of interkinetic nuclear movement and spatially varying
rates of neuronal differentiation. Simulations predict that tissue growth and
the shape of lineage-related clones of cells differ with the rate of differentiation.
Growth is isotropic in regions of high differentiation, but dorsoventrally biased
in regions of low differentiation. This is consistent with experimental observations.
The absence of directional signalling in the simulations indicates that global
mechanical constraints are sufficient to explain the observed differences in anisotropy.
This provides insight into how the tissue growth rate affects cell dynamics and
growth anisotropy and opens up possibilities to study the coupling between mechanics,
pattern formation and growth in the neural tube.
article_number: dev176297
article_processing_charge: No
article_type: original
author:
- first_name: Pilar
full_name: Guerrero, Pilar
last_name: Guerrero
- first_name: Ruben
full_name: Perez-Carrasco, Ruben
last_name: Perez-Carrasco
- first_name: Marcin P
full_name: Zagórski, Marcin P
id: 343DA0DC-F248-11E8-B48F-1D18A9856A87
last_name: Zagórski
orcid: 0000-0001-7896-7762
- first_name: David
full_name: Page, David
last_name: Page
- first_name: Anna
full_name: Kicheva, Anna
id: 3959A2A0-F248-11E8-B48F-1D18A9856A87
last_name: Kicheva
orcid: 0000-0003-4509-4998
- first_name: James
full_name: Briscoe, James
last_name: Briscoe
- first_name: Karen M.
full_name: Page, Karen M.
last_name: Page
citation:
ama: Guerrero P, Perez-Carrasco R, Zagórski MP, et al. Neuronal differentiation
influences progenitor arrangement in the vertebrate neuroepithelium. Development.
2019;146(23). doi:10.1242/dev.176297
apa: Guerrero, P., Perez-Carrasco, R., Zagórski, M. P., Page, D., Kicheva, A., Briscoe,
J., & Page, K. M. (2019). Neuronal differentiation influences progenitor arrangement
in the vertebrate neuroepithelium. Development. The Company of Biologists.
https://doi.org/10.1242/dev.176297
chicago: Guerrero, Pilar, Ruben Perez-Carrasco, Marcin P Zagórski, David Page, Anna
Kicheva, James Briscoe, and Karen M. Page. “Neuronal Differentiation Influences
Progenitor Arrangement in the Vertebrate Neuroepithelium.” Development.
The Company of Biologists, 2019. https://doi.org/10.1242/dev.176297.
ieee: P. Guerrero et al., “Neuronal differentiation influences progenitor
arrangement in the vertebrate neuroepithelium,” Development, vol. 146,
no. 23. The Company of Biologists, 2019.
ista: Guerrero P, Perez-Carrasco R, Zagórski MP, Page D, Kicheva A, Briscoe J, Page
KM. 2019. Neuronal differentiation influences progenitor arrangement in the vertebrate
neuroepithelium. Development. 146(23), dev176297.
mla: Guerrero, Pilar, et al. “Neuronal Differentiation Influences Progenitor Arrangement
in the Vertebrate Neuroepithelium.” Development, vol. 146, no. 23, dev176297,
The Company of Biologists, 2019, doi:10.1242/dev.176297.
short: P. Guerrero, R. Perez-Carrasco, M.P. Zagórski, D. Page, A. Kicheva, J. Briscoe,
K.M. Page, Development 146 (2019).
date_created: 2019-12-10T14:39:50Z
date_published: 2019-12-04T00:00:00Z
date_updated: 2023-09-06T11:26:36Z
day: '04'
ddc:
- '570'
department:
- _id: AnKi
doi: 10.1242/dev.176297
ec_funded: 1
external_id:
isi:
- '000507575700004'
pmid:
- '31784457'
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checksum: b6533c37dc8fbd803ffeca216e0a8b8a
content_type: application/pdf
creator: dernst
date_created: 2019-12-13T07:34:06Z
date_updated: 2020-07-14T12:47:50Z
file_id: '7177'
file_name: 2019_Development_Guerrero.pdf
file_size: 7797881
relation: main_file
file_date_updated: 2020-07-14T12:47:50Z
has_accepted_license: '1'
intvolume: ' 146'
isi: 1
issue: '23'
language:
- iso: eng
month: '12'
oa: 1
oa_version: Published Version
pmid: 1
project:
- _id: B6FC0238-B512-11E9-945C-1524E6697425
call_identifier: H2020
grant_number: '680037'
name: Coordination of Patterning And Growth In the Spinal Cord
publication: Development
publication_identifier:
eissn:
- 1477-9129
issn:
- 0950-1991
publication_status: published
publisher: The Company of Biologists
quality_controlled: '1'
scopus_import: '1'
status: public
title: Neuronal differentiation influences progenitor arrangement in the vertebrate
neuroepithelium
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 146
year: '2019'
...
---
_id: '314'
abstract:
- lang: eng
text: The interface of physics and biology pro-vides a fruitful environment for
generatingnew concepts and exciting ways forwardto understanding living matter.
Examplesof successful studies include the estab-lishment and readout of morphogen
gra-dients during development, signal pro-cessing in protein and genetic networks,the
role of fluctuations in determining thefates of cells and tissues, and collectiveeffects
in proteins and in tissues. It is nothard to envision that significant further
ad-vances will translate to societal benefitsby initiating the development of new
de-vices and strategies for curing disease.However, research at the interface
posesvarious challenges, in particular for youngscientists, and current institutions
arerarely designed to facilitate such scientificprograms. In this Letter, we propose
aninternational initiative that addressesthese challenges through the establish-ment
of a worldwide network of platformsfor cross-disciplinary training and incuba-tors
for starting new collaborations.
article_processing_charge: No
article_type: letter_note
author:
- first_name: Guntram
full_name: Bauer, Guntram
last_name: Bauer
- first_name: Nikta
full_name: Fakhri, Nikta
last_name: Fakhri
- first_name: Anna
full_name: Kicheva, Anna
id: 3959A2A0-F248-11E8-B48F-1D18A9856A87
last_name: Kicheva
orcid: 0000-0003-4509-4998
- first_name: Jané
full_name: Kondev, Jané
last_name: Kondev
- first_name: Karsten
full_name: Kruse, Karsten
last_name: Kruse
- first_name: Hiroyuki
full_name: Noji, Hiroyuki
last_name: Noji
- first_name: Daniel
full_name: Riveline, Daniel
last_name: Riveline
- first_name: Timothy
full_name: Saunders, Timothy
last_name: Saunders
- first_name: Mukund
full_name: Thatta, Mukund
last_name: Thatta
- first_name: Eric
full_name: Wieschaus, Eric
last_name: Wieschaus
citation:
ama: Bauer G, Fakhri N, Kicheva A, et al. The science of living matter for tomorrow.
Cell Systems. 2018;6(4):400-402. doi:10.1016/j.cels.2018.04.003
apa: Bauer, G., Fakhri, N., Kicheva, A., Kondev, J., Kruse, K., Noji, H., … Wieschaus,
E. (2018). The science of living matter for tomorrow. Cell Systems. Cell
Press. https://doi.org/10.1016/j.cels.2018.04.003
chicago: Bauer, Guntram, Nikta Fakhri, Anna Kicheva, Jané Kondev, Karsten Kruse,
Hiroyuki Noji, Daniel Riveline, Timothy Saunders, Mukund Thatta, and Eric Wieschaus.
“The Science of Living Matter for Tomorrow.” Cell Systems. Cell Press,
2018. https://doi.org/10.1016/j.cels.2018.04.003.
ieee: G. Bauer et al., “The science of living matter for tomorrow,” Cell
Systems, vol. 6, no. 4. Cell Press, pp. 400–402, 2018.
ista: Bauer G, Fakhri N, Kicheva A, Kondev J, Kruse K, Noji H, Riveline D, Saunders
T, Thatta M, Wieschaus E. 2018. The science of living matter for tomorrow. Cell
Systems. 6(4), 400–402.
mla: Bauer, Guntram, et al. “The Science of Living Matter for Tomorrow.” Cell
Systems, vol. 6, no. 4, Cell Press, 2018, pp. 400–02, doi:10.1016/j.cels.2018.04.003.
short: G. Bauer, N. Fakhri, A. Kicheva, J. Kondev, K. Kruse, H. Noji, D. Riveline,
T. Saunders, M. Thatta, E. Wieschaus, Cell Systems 6 (2018) 400–402.
date_created: 2018-12-11T11:45:46Z
date_published: 2018-04-25T00:00:00Z
date_updated: 2023-09-19T10:11:25Z
day: '25'
department:
- _id: AnKi
doi: 10.1016/j.cels.2018.04.003
external_id:
isi:
- '000432192100003'
pmid:
- '29698645'
intvolume: ' 6'
isi: 1
issue: '4'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1016/j.cels.2018.04.003
month: '04'
oa: 1
oa_version: Published Version
page: 400 - 402
pmid: 1
publication: Cell Systems
publication_identifier:
eissn:
- 2405-4712
publication_status: published
publisher: Cell Press
publist_id: '7551'
quality_controlled: '1'
scopus_import: '1'
status: public
title: The science of living matter for tomorrow
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 6
year: '2018'
...
---
_id: '162'
abstract:
- lang: eng
text: 'Facial shape is the basis for facial recognition and categorization. Facial
features reflect the underlying geometry of the skeletal structures. Here, we
reveal that cartilaginous nasal capsule (corresponding to upper jaw and face)
is shaped by signals generated by neural structures: brain and olfactory epithelium.
Brain-derived Sonic Hedgehog (SHH) enables the induction of nasal septum and posterior
nasal capsule, whereas the formation of a capsule roof is controlled by signals
from the olfactory epithelium. Unexpectedly, the cartilage of the nasal capsule
turned out to be important for shaping membranous facial bones during development.
This suggests that conserved neurosensory structures could benefit from protection
and have evolved signals inducing cranial cartilages encasing them. Experiments
with mutant mice revealed that the genomic regulatory regions controlling production
of SHH in the nervous system contribute to facial cartilage morphogenesis, which
might be a mechanism responsible for the adaptive evolution of animal faces and
snouts.'
article_number: e34465
article_processing_charge: No
author:
- first_name: Marketa
full_name: Kaucka, Marketa
last_name: Kaucka
- first_name: Julian
full_name: Petersen, Julian
last_name: Petersen
- first_name: Marketa
full_name: Tesarova, Marketa
last_name: Tesarova
- first_name: Bara
full_name: Szarowska, Bara
last_name: Szarowska
- first_name: Maria
full_name: Kastriti, Maria
last_name: Kastriti
- first_name: Meng
full_name: Xie, Meng
last_name: Xie
- first_name: Anna
full_name: Kicheva, Anna
id: 3959A2A0-F248-11E8-B48F-1D18A9856A87
last_name: Kicheva
orcid: 0000-0003-4509-4998
- first_name: Karl
full_name: Annusver, Karl
last_name: Annusver
- first_name: Maria
full_name: Kasper, Maria
last_name: Kasper
- first_name: Orsolya
full_name: Symmons, Orsolya
last_name: Symmons
- first_name: Leslie
full_name: Pan, Leslie
last_name: Pan
- first_name: Francois
full_name: Spitz, Francois
last_name: Spitz
- first_name: Jozef
full_name: Kaiser, Jozef
last_name: Kaiser
- first_name: Maria
full_name: Hovorakova, Maria
last_name: Hovorakova
- first_name: Tomas
full_name: Zikmund, Tomas
last_name: Zikmund
- first_name: Kazunori
full_name: Sunadome, Kazunori
last_name: Sunadome
- first_name: Michael P
full_name: Matise, Michael P
last_name: Matise
- first_name: Hui
full_name: Wang, Hui
last_name: Wang
- first_name: Ulrika
full_name: Marklund, Ulrika
last_name: Marklund
- first_name: Hind
full_name: Abdo, Hind
last_name: Abdo
- first_name: Patrik
full_name: Ernfors, Patrik
last_name: Ernfors
- first_name: Pascal
full_name: Maire, Pascal
last_name: Maire
- first_name: Maud
full_name: Wurmser, Maud
last_name: Wurmser
- first_name: Andrei S
full_name: Chagin, Andrei S
last_name: Chagin
- first_name: Kaj
full_name: Fried, Kaj
last_name: Fried
- first_name: Igor
full_name: Adameyko, Igor
last_name: Adameyko
citation:
ama: Kaucka M, Petersen J, Tesarova M, et al. Signals from the brain and olfactory
epithelium control shaping of the mammalian nasal capsule cartilage. eLife.
2018;7. doi:10.7554/eLife.34465
apa: Kaucka, M., Petersen, J., Tesarova, M., Szarowska, B., Kastriti, M., Xie, M.,
… Adameyko, I. (2018). Signals from the brain and olfactory epithelium control
shaping of the mammalian nasal capsule cartilage. ELife. eLife Sciences
Publications. https://doi.org/10.7554/eLife.34465
chicago: Kaucka, Marketa, Julian Petersen, Marketa Tesarova, Bara Szarowska, Maria
Kastriti, Meng Xie, Anna Kicheva, et al. “Signals from the Brain and Olfactory
Epithelium Control Shaping of the Mammalian Nasal Capsule Cartilage.” ELife.
eLife Sciences Publications, 2018. https://doi.org/10.7554/eLife.34465.
ieee: M. Kaucka et al., “Signals from the brain and olfactory epithelium
control shaping of the mammalian nasal capsule cartilage,” eLife, vol.
7. eLife Sciences Publications, 2018.
ista: Kaucka M, Petersen J, Tesarova M, Szarowska B, Kastriti M, Xie M, Kicheva
A, Annusver K, Kasper M, Symmons O, Pan L, Spitz F, Kaiser J, Hovorakova M, Zikmund
T, Sunadome K, Matise MP, Wang H, Marklund U, Abdo H, Ernfors P, Maire P, Wurmser
M, Chagin AS, Fried K, Adameyko I. 2018. Signals from the brain and olfactory
epithelium control shaping of the mammalian nasal capsule cartilage. eLife. 7,
e34465.
mla: Kaucka, Marketa, et al. “Signals from the Brain and Olfactory Epithelium Control
Shaping of the Mammalian Nasal Capsule Cartilage.” ELife, vol. 7, e34465,
eLife Sciences Publications, 2018, doi:10.7554/eLife.34465.
short: M. Kaucka, J. Petersen, M. Tesarova, B. Szarowska, M. Kastriti, M. Xie, A.
Kicheva, K. Annusver, M. Kasper, O. Symmons, L. Pan, F. Spitz, J. Kaiser, M. Hovorakova,
T. Zikmund, K. Sunadome, M.P. Matise, H. Wang, U. Marklund, H. Abdo, P. Ernfors,
P. Maire, M. Wurmser, A.S. Chagin, K. Fried, I. Adameyko, ELife 7 (2018).
date_created: 2018-12-11T11:44:57Z
date_published: 2018-06-13T00:00:00Z
date_updated: 2023-09-18T09:29:07Z
day: '13'
ddc:
- '571'
department:
- _id: AnKi
doi: 10.7554/eLife.34465
ec_funded: 1
external_id:
isi:
- '000436227500001'
file:
- access_level: open_access
checksum: da2378cdcf6b5461dcde194e4d608343
content_type: application/pdf
creator: dernst
date_created: 2018-12-17T16:41:58Z
date_updated: 2020-07-14T12:45:07Z
file_id: '5727'
file_name: 2018_eLife_Kaucka.pdf
file_size: 9816484
relation: main_file
file_date_updated: 2020-07-14T12:45:07Z
has_accepted_license: '1'
intvolume: ' 7'
isi: 1
language:
- iso: eng
month: '06'
oa: 1
oa_version: Published Version
project:
- _id: B6FC0238-B512-11E9-945C-1524E6697425
call_identifier: H2020
grant_number: '680037'
name: Coordination of Patterning And Growth In the Spinal Cord
publication: eLife
publication_status: published
publisher: eLife Sciences Publications
publist_id: '7759'
quality_controlled: '1'
related_material:
record:
- id: '9838'
relation: research_data
status: public
scopus_import: '1'
status: public
title: Signals from the brain and olfactory epithelium control shaping of the mammalian
nasal capsule cartilage
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 7
year: '2018'
...
---
_id: '9838'
abstract:
- lang: eng
text: 'Facial shape is the basis for facial recognition and categorization. Facial
features reflect the underlying geometry of the skeletal structures. Here we reveal
that cartilaginous nasal capsule (corresponding to upper jaw and face) is shaped
by signals generated by neural structures: brain and olfactory epithelium. Brain-derived
Sonic Hedgehog (SHH) enables the induction of nasal septum and posterior nasal
capsule, whereas the formation of a capsule roof is controlled by signals from
the olfactory epithelium. Unexpectedly, the cartilage of the nasal capsule turned
out to be important for shaping membranous facial bones during development. This
suggests that conserved neurosensory structures could benefit from protection
and have evolved signals inducing cranial cartilages encasing them. Experiments
with mutant mice revealed that the genomic regulatory regions controlling production
of SHH in the nervous system contribute to facial cartilage morphogenesis, which
might be a mechanism responsible for the adaptive evolution of animal faces and
snouts.'
article_processing_charge: No
author:
- first_name: Marketa
full_name: Kaucka, Marketa
last_name: Kaucka
- first_name: Julian
full_name: Petersen, Julian
last_name: Petersen
- first_name: Marketa
full_name: Tesarova, Marketa
last_name: Tesarova
- first_name: Bara
full_name: Szarowska, Bara
last_name: Szarowska
- first_name: Maria Eleni
full_name: Kastriti, Maria Eleni
last_name: Kastriti
- first_name: Meng
full_name: Xie, Meng
last_name: Xie
- first_name: Anna
full_name: Kicheva, Anna
id: 3959A2A0-F248-11E8-B48F-1D18A9856A87
last_name: Kicheva
orcid: 0000-0003-4509-4998
- first_name: Karl
full_name: Annusver, Karl
last_name: Annusver
- first_name: Maria
full_name: Kasper, Maria
last_name: Kasper
- first_name: Orsolya
full_name: Symmons, Orsolya
last_name: Symmons
- first_name: Leslie
full_name: Pan, Leslie
last_name: Pan
- first_name: Francois
full_name: Spitz, Francois
last_name: Spitz
- first_name: Jozef
full_name: Kaiser, Jozef
last_name: Kaiser
- first_name: Maria
full_name: Hovorakova, Maria
last_name: Hovorakova
- first_name: Tomas
full_name: Zikmund, Tomas
last_name: Zikmund
- first_name: Kazunori
full_name: Sunadome, Kazunori
last_name: Sunadome
- first_name: Michael P
full_name: Matise, Michael P
last_name: Matise
- first_name: Hui
full_name: Wang, Hui
last_name: Wang
- first_name: Ulrika
full_name: Marklund, Ulrika
last_name: Marklund
- first_name: Hind
full_name: Abdo, Hind
last_name: Abdo
- first_name: Patrik
full_name: Ernfors, Patrik
last_name: Ernfors
- first_name: Pascal
full_name: Maire, Pascal
last_name: Maire
- first_name: Maud
full_name: Wurmser, Maud
last_name: Wurmser
- first_name: Andrei S
full_name: Chagin, Andrei S
last_name: Chagin
- first_name: Kaj
full_name: Fried, Kaj
last_name: Fried
- first_name: Igor
full_name: Adameyko, Igor
last_name: Adameyko
citation:
ama: 'Kaucka M, Petersen J, Tesarova M, et al. Data from: Signals from the brain
and olfactory epithelium control shaping of the mammalian nasal capsule cartilage.
2018. doi:10.5061/dryad.f1s76f2'
apa: 'Kaucka, M., Petersen, J., Tesarova, M., Szarowska, B., Kastriti, M. E., Xie,
M., … Adameyko, I. (2018). Data from: Signals from the brain and olfactory epithelium
control shaping of the mammalian nasal capsule cartilage. Dryad. https://doi.org/10.5061/dryad.f1s76f2'
chicago: 'Kaucka, Marketa, Julian Petersen, Marketa Tesarova, Bara Szarowska, Maria
Eleni Kastriti, Meng Xie, Anna Kicheva, et al. “Data from: Signals from the Brain
and Olfactory Epithelium Control Shaping of the Mammalian Nasal Capsule Cartilage.”
Dryad, 2018. https://doi.org/10.5061/dryad.f1s76f2.'
ieee: 'M. Kaucka et al., “Data from: Signals from the brain and olfactory
epithelium control shaping of the mammalian nasal capsule cartilage.” Dryad, 2018.'
ista: 'Kaucka M, Petersen J, Tesarova M, Szarowska B, Kastriti ME, Xie M, Kicheva
A, Annusver K, Kasper M, Symmons O, Pan L, Spitz F, Kaiser J, Hovorakova M, Zikmund
T, Sunadome K, Matise MP, Wang H, Marklund U, Abdo H, Ernfors P, Maire P, Wurmser
M, Chagin AS, Fried K, Adameyko I. 2018. Data from: Signals from the brain and
olfactory epithelium control shaping of the mammalian nasal capsule cartilage,
Dryad, 10.5061/dryad.f1s76f2.'
mla: 'Kaucka, Marketa, et al. Data from: Signals from the Brain and Olfactory
Epithelium Control Shaping of the Mammalian Nasal Capsule Cartilage. Dryad,
2018, doi:10.5061/dryad.f1s76f2.'
short: M. Kaucka, J. Petersen, M. Tesarova, B. Szarowska, M.E. Kastriti, M. Xie,
A. Kicheva, K. Annusver, M. Kasper, O. Symmons, L. Pan, F. Spitz, J. Kaiser, M.
Hovorakova, T. Zikmund, K. Sunadome, M.P. Matise, H. Wang, U. Marklund, H. Abdo,
P. Ernfors, P. Maire, M. Wurmser, A.S. Chagin, K. Fried, I. Adameyko, (2018).
date_created: 2021-08-09T12:54:35Z
date_published: 2018-06-14T00:00:00Z
date_updated: 2023-09-18T09:29:07Z
day: '14'
department:
- _id: AnKi
doi: 10.5061/dryad.f1s76f2
main_file_link:
- open_access: '1'
url: https://doi.org/10.5061/dryad.f1s76f2
month: '06'
oa: 1
oa_version: Published Version
publisher: Dryad
related_material:
record:
- id: '162'
relation: used_in_publication
status: public
status: public
title: 'Data from: Signals from the brain and olfactory epithelium control shaping
of the mammalian nasal capsule cartilage'
type: research_data_reference
user_id: 6785fbc1-c503-11eb-8a32-93094b40e1cf
year: '2018'
...
---
_id: '37'
abstract:
- lang: eng
text: Developmental processes are inherently dynamic and understanding them requires
quantitative measurements of gene and protein expression levels in space and time.
While live imaging is a powerful approach for obtaining such data, it is still
a challenge to apply it over long periods of time to large tissues, such as the
embryonic spinal cord in mouse and chick. Nevertheless, dynamics of gene expression
and signaling activity patterns in this organ can be studied by collecting tissue
sections at different developmental stages. In combination with immunohistochemistry,
this allows for measuring the levels of multiple developmental regulators in a
quantitative manner with high spatiotemporal resolution. The mean protein expression
levels over time, as well as embryo-to-embryo variability can be analyzed. A key
aspect of the approach is the ability to compare protein levels across different
samples. This requires a number of considerations in sample preparation, imaging
and data analysis. Here we present a protocol for obtaining time course data of
dorsoventral expression patterns from mouse and chick neural tube in the first
3 days of neural tube development. The described workflow starts from embryo dissection
and ends with a processed dataset. Software scripts for data analysis are included.
The protocol is adaptable and instructions that allow the user to modify different
steps are provided. Thus, the procedure can be altered for analysis of time-lapse
images and applied to systems other than the neural tube.
alternative_title:
- Methods in Molecular Biology
article_processing_charge: No
author:
- first_name: Marcin P
full_name: Zagórski, Marcin P
id: 343DA0DC-F248-11E8-B48F-1D18A9856A87
last_name: Zagórski
orcid: 0000-0001-7896-7762
- first_name: Anna
full_name: Kicheva, Anna
id: 3959A2A0-F248-11E8-B48F-1D18A9856A87
last_name: Kicheva
orcid: 0000-0003-4509-4998
citation:
ama: 'Zagórski MP, Kicheva A. Measuring dorsoventral pattern and morphogen signaling
profiles in the growing neural tube. In: Morphogen Gradients . Vol 1863.
MIMB. Springer Nature; 2018:47-63. doi:10.1007/978-1-4939-8772-6_4'
apa: Zagórski, M. P., & Kicheva, A. (2018). Measuring dorsoventral pattern and
morphogen signaling profiles in the growing neural tube. In Morphogen Gradients
(Vol. 1863, pp. 47–63). Springer Nature. https://doi.org/10.1007/978-1-4939-8772-6_4
chicago: Zagórski, Marcin P, and Anna Kicheva. “Measuring Dorsoventral Pattern and
Morphogen Signaling Profiles in the Growing Neural Tube.” In Morphogen Gradients
, 1863:47–63. MIMB. Springer Nature, 2018. https://doi.org/10.1007/978-1-4939-8772-6_4.
ieee: M. P. Zagórski and A. Kicheva, “Measuring dorsoventral pattern and morphogen
signaling profiles in the growing neural tube,” in Morphogen Gradients ,
vol. 1863, Springer Nature, 2018, pp. 47–63.
ista: 'Zagórski MP, Kicheva A. 2018.Measuring dorsoventral pattern and morphogen
signaling profiles in the growing neural tube. In: Morphogen Gradients . Methods
in Molecular Biology, vol. 1863, 47–63.'
mla: Zagórski, Marcin P., and Anna Kicheva. “Measuring Dorsoventral Pattern and
Morphogen Signaling Profiles in the Growing Neural Tube.” Morphogen Gradients
, vol. 1863, Springer Nature, 2018, pp. 47–63, doi:10.1007/978-1-4939-8772-6_4.
short: M.P. Zagórski, A. Kicheva, in:, Morphogen Gradients , Springer Nature, 2018,
pp. 47–63.
date_created: 2018-12-11T11:44:17Z
date_published: 2018-10-16T00:00:00Z
date_updated: 2021-01-12T07:49:03Z
day: '16'
ddc:
- '570'
department:
- _id: AnKi
doi: 10.1007/978-1-4939-8772-6_4
ec_funded: 1
file:
- access_level: open_access
checksum: 2a97d0649fdcfcf1bdca7c8ad1dce71b
content_type: application/pdf
creator: dernst
date_created: 2020-10-13T14:20:37Z
date_updated: 2020-10-13T14:20:37Z
file_id: '8656'
file_name: 2018_MIMB_Zagorski.pdf
file_size: 4906815
relation: main_file
success: 1
file_date_updated: 2020-10-13T14:20:37Z
has_accepted_license: '1'
intvolume: ' 1863'
language:
- iso: eng
month: '10'
oa: 1
oa_version: Submitted Version
page: 47 - 63
project:
- _id: B6FC0238-B512-11E9-945C-1524E6697425
call_identifier: H2020
grant_number: '680037'
name: Coordination of Patterning And Growth In the Spinal Cord
publication: 'Morphogen Gradients '
publication_identifier:
isbn:
- 978-1-4939-8771-9
issn:
- 1064-3745
publication_status: published
publisher: Springer Nature
publist_id: '8018'
quality_controlled: '1'
scopus_import: '1'
series_title: MIMB
status: public
title: Measuring dorsoventral pattern and morphogen signaling profiles in the growing
neural tube
type: book_chapter
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 1863
year: '2018'
...
---
_id: '685'
abstract:
- lang: eng
text: By applying methods and principles from the physical sciences to biological
problems, D'Arcy Thompson's On Growth and Form demonstrated how mathematical reasoning
reveals elegant, simple explanations for seemingly complex processes. This has
had a profound influence on subsequent generations of developmental biologists.
We discuss how this influence can be traced through twentieth century morphologists,
embryologists and theoreticians to current research that explores the molecular
and cellular mechanisms of tissue growth and patterning, including our own studies
of the vertebrate neural tube.
author:
- first_name: James
full_name: Briscoe, James
last_name: Briscoe
- first_name: Anna
full_name: Kicheva, Anna
id: 3959A2A0-F248-11E8-B48F-1D18A9856A87
last_name: Kicheva
orcid: 0000-0003-4509-4998
citation:
ama: Briscoe J, Kicheva A. The physics of development 100 years after D’Arcy Thompson’s
“on growth and form.” Mechanisms of Development. 2017;145:26-31. doi:10.1016/j.mod.2017.03.005
apa: Briscoe, J., & Kicheva, A. (2017). The physics of development 100 years
after D’Arcy Thompson’s “on growth and form.” Mechanisms of Development.
Elsevier. https://doi.org/10.1016/j.mod.2017.03.005
chicago: Briscoe, James, and Anna Kicheva. “The Physics of Development 100 Years
after D’Arcy Thompson’s ‘on Growth and Form.’” Mechanisms of Development.
Elsevier, 2017. https://doi.org/10.1016/j.mod.2017.03.005.
ieee: J. Briscoe and A. Kicheva, “The physics of development 100 years after D’Arcy
Thompson’s ‘on growth and form,’” Mechanisms of Development, vol. 145.
Elsevier, pp. 26–31, 2017.
ista: Briscoe J, Kicheva A. 2017. The physics of development 100 years after D’Arcy
Thompson’s “on growth and form”. Mechanisms of Development. 145, 26–31.
mla: Briscoe, James, and Anna Kicheva. “The Physics of Development 100 Years after
D’Arcy Thompson’s ‘on Growth and Form.’” Mechanisms of Development, vol.
145, Elsevier, 2017, pp. 26–31, doi:10.1016/j.mod.2017.03.005.
short: J. Briscoe, A. Kicheva, Mechanisms of Development 145 (2017) 26–31.
date_created: 2018-12-11T11:47:55Z
date_published: 2017-06-01T00:00:00Z
date_updated: 2021-01-12T08:09:20Z
day: '01'
ddc:
- '571'
department:
- _id: AnKi
doi: 10.1016/j.mod.2017.03.005
ec_funded: 1
external_id:
pmid:
- '28366718'
file:
- access_level: open_access
checksum: 727043d2e4199fbef6b3704e6d1ac105
content_type: application/pdf
creator: dernst
date_created: 2019-04-17T07:58:48Z
date_updated: 2020-07-14T12:47:42Z
file_id: '6335'
file_name: 2017_Briscoe_Kicheva_and_DArcy_accepted_version.pdf
file_size: 652313
relation: main_file
file_date_updated: 2020-07-14T12:47:42Z
has_accepted_license: '1'
intvolume: ' 145'
language:
- iso: eng
month: '06'
oa: 1
oa_version: Submitted Version
page: 26 - 31
pmid: 1
project:
- _id: B6FC0238-B512-11E9-945C-1524E6697425
call_identifier: H2020
grant_number: '680037'
name: Coordination of Patterning And Growth In the Spinal Cord
publication: Mechanisms of Development
publication_identifier:
issn:
- '09254773'
publication_status: published
publisher: Elsevier
publist_id: '7025'
pubrep_id: '985'
quality_controlled: '1'
scopus_import: 1
status: public
title: The physics of development 100 years after D'Arcy Thompson's “on growth and
form”
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 145
year: '2017'
...
---
_id: '654'
abstract:
- lang: eng
text: In November 2016, developmental biologists, synthetic biologists and engineers
gathered in Paris for a meeting called ‘Engineering the embryo’. The participants
shared an interest in exploring how synthetic systems can reveal new principles
of embryonic development, and how the in vitro manipulation and modeling of development
using stem cells can be used to integrate ideas and expertise from physics, developmental
biology and tissue engineering. As we review here, the conference pinpointed some
of the challenges arising at the intersection of these fields, along with great
enthusiasm for finding new approaches and collaborations.
author:
- first_name: Anna
full_name: Kicheva, Anna
id: 3959A2A0-F248-11E8-B48F-1D18A9856A87
last_name: Kicheva
orcid: 0000-0003-4509-4998
- first_name: Nicolas
full_name: Rivron, Nicolas
last_name: Rivron
citation:
ama: Kicheva A, Rivron N. Creating to understand – developmental biology meets engineering
in Paris. Development. 2017;144(5):733-736. doi:10.1242/dev.144915
apa: Kicheva, A., & Rivron, N. (2017). Creating to understand – developmental
biology meets engineering in Paris. Development. Company of Biologists.
https://doi.org/10.1242/dev.144915
chicago: Kicheva, Anna, and Nicolas Rivron. “Creating to Understand – Developmental
Biology Meets Engineering in Paris.” Development. Company of Biologists,
2017. https://doi.org/10.1242/dev.144915.
ieee: A. Kicheva and N. Rivron, “Creating to understand – developmental biology
meets engineering in Paris,” Development, vol. 144, no. 5. Company of Biologists,
pp. 733–736, 2017.
ista: Kicheva A, Rivron N. 2017. Creating to understand – developmental biology
meets engineering in Paris. Development. 144(5), 733–736.
mla: Kicheva, Anna, and Nicolas Rivron. “Creating to Understand – Developmental
Biology Meets Engineering in Paris.” Development, vol. 144, no. 5, Company
of Biologists, 2017, pp. 733–36, doi:10.1242/dev.144915.
short: A. Kicheva, N. Rivron, Development 144 (2017) 733–736.
date_created: 2018-12-11T11:47:44Z
date_published: 2017-03-01T00:00:00Z
date_updated: 2021-01-12T08:07:54Z
day: '01'
ddc:
- '571'
department:
- _id: AnKi
doi: 10.1242/dev.144915
ec_funded: 1
file:
- access_level: open_access
checksum: eef22a0f42a55b232cb2d1188a2322cb
content_type: application/pdf
creator: system
date_created: 2018-12-12T10:15:20Z
date_updated: 2020-07-14T12:47:33Z
file_id: '5139'
file_name: IST-2018-987-v1+1_2017_KichevaRivron__Creating_to.pdf
file_size: 228206
relation: main_file
file_date_updated: 2020-07-14T12:47:33Z
has_accepted_license: '1'
intvolume: ' 144'
issue: '5'
language:
- iso: eng
month: '03'
oa: 1
oa_version: Submitted Version
page: 733 - 736
project:
- _id: B6FC0238-B512-11E9-945C-1524E6697425
call_identifier: H2020
grant_number: '680037'
name: Coordination of Patterning And Growth In the Spinal Cord
publication: Development
publication_identifier:
issn:
- '09501991'
publication_status: published
publisher: Company of Biologists
publist_id: '7089'
pubrep_id: '987'
quality_controlled: '1'
scopus_import: 1
status: public
title: Creating to understand – developmental biology meets engineering in Paris
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 144
year: '2017'
...
---
_id: '943'
abstract:
- lang: eng
text: Like many developing tissues, the vertebrate neural tube is patterned by antiparallel
morphogen gradients. To understand how these inputs are interpreted, we measured
morphogen signaling and target gene expression in mouse embryos and chick ex vivo
assays. From these data, we derived and validated a characteristic decoding map
that relates morphogen input to the positional identity of neural progenitors.
Analysis of the observed responses indicates that the underlying interpretation
strategy minimizes patterning errors in response to the joint input of noisy opposing
gradients. We reverse-engineered a transcriptional network that provides a mechanistic
basis for the observed cell fate decisions and accounts for the precision and
dynamics of pattern formation. Together, our data link opposing gradient dynamics
in a growing tissue to precise pattern formation.
article_processing_charge: No
author:
- first_name: Marcin P
full_name: Zagórski, Marcin P
id: 343DA0DC-F248-11E8-B48F-1D18A9856A87
last_name: Zagórski
orcid: 0000-0001-7896-7762
- first_name: Yoji
full_name: Tabata, Yoji
last_name: Tabata
- first_name: Nathalie
full_name: Brandenberg, Nathalie
last_name: Brandenberg
- first_name: Matthias
full_name: Lutolf, Matthias
last_name: Lutolf
- first_name: Gasper
full_name: Tkacik, Gasper
id: 3D494DCA-F248-11E8-B48F-1D18A9856A87
last_name: Tkacik
orcid: 0000-0002-6699-1455
- first_name: Tobias
full_name: Bollenbach, Tobias
last_name: Bollenbach
- first_name: James
full_name: Briscoe, James
last_name: Briscoe
- first_name: Anna
full_name: Kicheva, Anna
id: 3959A2A0-F248-11E8-B48F-1D18A9856A87
last_name: Kicheva
orcid: 0000-0003-4509-4998
citation:
ama: Zagórski MP, Tabata Y, Brandenberg N, et al. Decoding of position in the developing
neural tube from antiparallel morphogen gradients. Science. 2017;356(6345):1379-1383.
doi:10.1126/science.aam5887
apa: Zagórski, M. P., Tabata, Y., Brandenberg, N., Lutolf, M., Tkačik, G., Bollenbach,
T., … Kicheva, A. (2017). Decoding of position in the developing neural tube from
antiparallel morphogen gradients. Science. American Association for the
Advancement of Science. https://doi.org/10.1126/science.aam5887
chicago: Zagórski, Marcin P, Yoji Tabata, Nathalie Brandenberg, Matthias Lutolf,
Gašper Tkačik, Tobias Bollenbach, James Briscoe, and Anna Kicheva. “Decoding of
Position in the Developing Neural Tube from Antiparallel Morphogen Gradients.”
Science. American Association for the Advancement of Science, 2017. https://doi.org/10.1126/science.aam5887.
ieee: M. P. Zagórski et al., “Decoding of position in the developing neural
tube from antiparallel morphogen gradients,” Science, vol. 356, no. 6345.
American Association for the Advancement of Science, pp. 1379–1383, 2017.
ista: Zagórski MP, Tabata Y, Brandenberg N, Lutolf M, Tkačik G, Bollenbach T, Briscoe
J, Kicheva A. 2017. Decoding of position in the developing neural tube from antiparallel
morphogen gradients. Science. 356(6345), 1379–1383.
mla: Zagórski, Marcin P., et al. “Decoding of Position in the Developing Neural
Tube from Antiparallel Morphogen Gradients.” Science, vol. 356, no. 6345,
American Association for the Advancement of Science, 2017, pp. 1379–83, doi:10.1126/science.aam5887.
short: M.P. Zagórski, Y. Tabata, N. Brandenberg, M. Lutolf, G. Tkačik, T. Bollenbach,
J. Briscoe, A. Kicheva, Science 356 (2017) 1379–1383.
date_created: 2018-12-11T11:49:20Z
date_published: 2017-06-30T00:00:00Z
date_updated: 2023-09-26T15:38:05Z
day: '30'
department:
- _id: AnKi
- _id: GaTk
doi: 10.1126/science.aam5887
ec_funded: 1
external_id:
isi:
- '000404351500036'
pmid:
- '28663499'
intvolume: ' 356'
isi: 1
issue: '6345'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5568706/
month: '06'
oa: 1
oa_version: Submitted Version
page: 1379 - 1383
pmid: 1
project:
- _id: 254E9036-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: P28844-B27
name: Biophysics of information processing in gene regulation
- _id: B6FC0238-B512-11E9-945C-1524E6697425
call_identifier: H2020
grant_number: '680037'
name: Coordination of Patterning And Growth In the Spinal Cord
- _id: 25681D80-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '291734'
name: International IST Postdoc Fellowship Programme
- _id: 2524F500-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '201439'
name: Developing High-Throughput Bioassays for Human Cancers in Zebrafish
publication: Science
publication_identifier:
issn:
- '00368075'
publication_status: published
publisher: American Association for the Advancement of Science
publist_id: '6474'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Decoding of position in the developing neural tube from antiparallel morphogen
gradients
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 356
year: '2017'
...
---
_id: '1728'
abstract:
- lang: eng
text: 'In the vertebrate neural tube, the morphogen Sonic Hedgehog (Shh) establishes
a characteristic pattern of gene expression. Here we quantify the Shh gradient
in the developing mouse neural tube and show that while the amplitude of the gradient
increases over time, the activity of the pathway transcriptional effectors, Gli
proteins, initially increases but later decreases. Computational analysis of the
pathway suggests three mechanisms that could contribute to this adaptation: transcriptional
upregulation of the inhibitory receptor Ptch1, transcriptional downregulation
of Gli and the differential stability of active and inactive Gli isoforms. Consistent
with this, Gli2 protein expression is downregulated during neural tube patterning
and adaptation continues when the pathway is stimulated downstream of Ptch1. Moreover,
the Shh-induced upregulation of Gli2 transcription prevents Gli activity levels
from adapting in a different cell type, NIH3T3 fibroblasts, despite the upregulation
of Ptch1. Multiple mechanisms therefore contribute to the intracellular dynamics
of Shh signalling, resulting in different signalling dynamics in different cell
types.'
acknowledgement: C.P.B. gratefully acknowledges funding from the Wellcome Trust through
a Research Career Development Fellowship (097319/Z/11/Z). This work was supported
by the Medical Research Council (U117560541) and Wellcome Trust (WT098326MA, WT098325MA).
author:
- first_name: Michael
full_name: Cohen, Michael H
last_name: Cohen
- first_name: Anna
full_name: Anna Kicheva
id: 3959A2A0-F248-11E8-B48F-1D18A9856A87
last_name: Kicheva
orcid: 0000-0003-4509-4998
- first_name: Ana
full_name: Ribeiro, Ana C
last_name: Ribeiro
- first_name: Robert
full_name: Blassberg, Robert A
last_name: Blassberg
- first_name: Karen
full_name: Page, Karen M
last_name: Page
- first_name: Chris
full_name: Barnes, Chris P
last_name: Barnes
- first_name: James
full_name: Briscoe, James
last_name: Briscoe
citation:
ama: Cohen M, Kicheva A, Ribeiro A, et al. Ptch1 and Gli regulate Shh signalling
dynamics via multiple mechanisms. Nature Communications. 2015;6. doi:10.1038/ncomms7709
apa: Cohen, M., Kicheva, A., Ribeiro, A., Blassberg, R., Page, K., Barnes, C., &
Briscoe, J. (2015). Ptch1 and Gli regulate Shh signalling dynamics via multiple
mechanisms. Nature Communications. Nature Publishing Group. https://doi.org/10.1038/ncomms7709
chicago: Cohen, Michael, Anna Kicheva, Ana Ribeiro, Robert Blassberg, Karen Page,
Chris Barnes, and James Briscoe. “Ptch1 and Gli Regulate Shh Signalling Dynamics
via Multiple Mechanisms.” Nature Communications. Nature Publishing Group,
2015. https://doi.org/10.1038/ncomms7709.
ieee: M. Cohen et al., “Ptch1 and Gli regulate Shh signalling dynamics via
multiple mechanisms,” Nature Communications, vol. 6. Nature Publishing
Group, 2015.
ista: Cohen M, Kicheva A, Ribeiro A, Blassberg R, Page K, Barnes C, Briscoe J. 2015.
Ptch1 and Gli regulate Shh signalling dynamics via multiple mechanisms. Nature
Communications. 6.
mla: Cohen, Michael, et al. “Ptch1 and Gli Regulate Shh Signalling Dynamics via
Multiple Mechanisms.” Nature Communications, vol. 6, Nature Publishing
Group, 2015, doi:10.1038/ncomms7709.
short: M. Cohen, A. Kicheva, A. Ribeiro, R. Blassberg, K. Page, C. Barnes, J. Briscoe,
Nature Communications 6 (2015).
date_created: 2018-12-11T11:53:42Z
date_published: 2015-04-02T00:00:00Z
date_updated: 2021-01-12T06:52:48Z
day: '02'
doi: 10.1038/ncomms7709
extern: 1
intvolume: ' 6'
month: '04'
publication: Nature Communications
publication_status: published
publisher: Nature Publishing Group
publist_id: '5399'
quality_controlled: 0
status: public
title: Ptch1 and Gli regulate Shh signalling dynamics via multiple mechanisms
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
volume: 6
year: '2015'
...
---
_id: '1726'
abstract:
- lang: eng
text: The development of a functional tissue requires coordination of the amplification
of progenitors and their differentiation into specific cell types. The molecular
basis for this coordination during myotome ontogeny is not well understood. Dermomytome
progenitors that colonize the myotome first acquire myocyte identity and subsequently
proliferate as Pax7-expressing progenitors before undergoing terminal differentiation.
We show that the dynamics of sonic hedgehog (Shh) signaling is crucial for this
transition in both avian and mouse embryos. Initially, Shh ligand emanating from
notochord/floor plate reaches the dermomyotome, where it both maintains the proliferation
of dermomyotome cells and promotes myogenic differentiation of progenitors that
colonized the myotome. Interfering with Shh signaling at this stage produces small
myotomes and accumulation of Pax7-expressing progenitors. An in vivo reporter
of Shh activity combined with mouse genetics revealed the existence of both activator
and repressor Shh activities operating on distinct subsets of cells during the
epaxial myotomal maturation. In contrast to observations in mice, in avians Shh
promotes the differentiation of both epaxial and hypaxial myotome domains. Subsequently,
myogenic progenitors become refractory to Shh; this is likely to occur at the
level of, or upstream of, smoothened signaling. The end of responsiveness to Shh
coincides with, and is thus likely to enable, the transition into the growth phase
of the myotome.
acknowledgement: This study was supported by grants from the Israel Science Foundation
(ISF) [11/09 to C.K.]; the Association Francaise contre les Myopathies (AFM) [15642
to C.K.]; the German Research Foundation (DFG) [UN 34/27-1 to C.K.]; the UK Medical
Research Council (MRC) [U117560541 to J.B. and A.K.]; Fondation Pour la Recherche
Médicale (FRM) (post-doctoral fellowship to V.R.). Deposited in PMC for release
after 6 months
author:
- first_name: Nitza
full_name: Kahane, Nitza
last_name: Kahane
- first_name: Vanessa
full_name: Ribes, Vanessa
last_name: Ribes
- first_name: Anna
full_name: Anna Kicheva
id: 3959A2A0-F248-11E8-B48F-1D18A9856A87
last_name: Kicheva
orcid: 0000-0003-4509-4998
- first_name: James
full_name: Briscoe, James
last_name: Briscoe
- first_name: Chaya
full_name: Kalcheim, Chaya
last_name: Kalcheim
citation:
ama: Kahane N, Ribes V, Kicheva A, Briscoe J, Kalcheim C. The transition from differentiation
to growth during dermomyotome-derived myogenesis depends on temporally restricted
hedgehog signaling. Development. 2013;140(8):1740-1750. doi:10.1242/dev.092726
apa: Kahane, N., Ribes, V., Kicheva, A., Briscoe, J., & Kalcheim, C. (2013).
The transition from differentiation to growth during dermomyotome-derived myogenesis
depends on temporally restricted hedgehog signaling. Development. Company
of Biologists. https://doi.org/10.1242/dev.092726
chicago: Kahane, Nitza, Vanessa Ribes, Anna Kicheva, James Briscoe, and Chaya Kalcheim.
“The Transition from Differentiation to Growth during Dermomyotome-Derived Myogenesis
Depends on Temporally Restricted Hedgehog Signaling.” Development. Company
of Biologists, 2013. https://doi.org/10.1242/dev.092726.
ieee: N. Kahane, V. Ribes, A. Kicheva, J. Briscoe, and C. Kalcheim, “The transition
from differentiation to growth during dermomyotome-derived myogenesis depends
on temporally restricted hedgehog signaling,” Development, vol. 140, no.
8. Company of Biologists, pp. 1740–1750, 2013.
ista: Kahane N, Ribes V, Kicheva A, Briscoe J, Kalcheim C. 2013. The transition
from differentiation to growth during dermomyotome-derived myogenesis depends
on temporally restricted hedgehog signaling. Development. 140(8), 1740–1750.
mla: Kahane, Nitza, et al. “The Transition from Differentiation to Growth during
Dermomyotome-Derived Myogenesis Depends on Temporally Restricted Hedgehog Signaling.”
Development, vol. 140, no. 8, Company of Biologists, 2013, pp. 1740–50,
doi:10.1242/dev.092726.
short: N. Kahane, V. Ribes, A. Kicheva, J. Briscoe, C. Kalcheim, Development 140
(2013) 1740–1750.
date_created: 2018-12-11T11:53:41Z
date_published: 2013-04-18T00:00:00Z
date_updated: 2021-01-12T06:52:47Z
day: '18'
doi: 10.1242/dev.092726
extern: 1
intvolume: ' 140'
issue: '8'
month: '04'
page: 1740 - 1750
publication: Development
publication_status: published
publisher: Company of Biologists
publist_id: '5402'
quality_controlled: 0
status: public
title: The transition from differentiation to growth during dermomyotome-derived myogenesis
depends on temporally restricted hedgehog signaling
type: journal_article
volume: 140
year: '2013'
...
---
_id: '1727'
abstract:
- lang: eng
text: 'Cells at different positions in a developing tissue receive different concentrations
of signaling molecules, called morphogens, and this influences their cell fate.
Morphogen concentration gradients have been proposed to control patterning as
well as growth in many developing tissues. Some outstanding questions about tissue
patterning by morphogen gradients are the following: What are the mechanisms that
regulate gradient formation and shape? Is the positional information encoded in
the gradient sufficiently precise to determine the positions of target gene domain
boundaries? What are the temporal dynamics of gradients and how do they relate
to patterning and growth? These questions are inherently quantitative in nature
and addressing them requires measuring morphogen concentrations in cells, levels
of downstream signaling activity, and kinetics of morphogen transport. Here we
first present methods for quantifying morphogen gradient shape in which the measurements
can be calibrated to reflect actual morphogen concentrations. We then discuss
using fluorescence recovery after photobleaching to study the kinetics of morphogen
transport at the tissue level. Finally, we present particle tracking as a method
to study morphogen intracellular trafficking.'
author:
- first_name: Anna
full_name: Anna Kicheva
id: 3959A2A0-F248-11E8-B48F-1D18A9856A87
last_name: Kicheva
orcid: 0000-0003-4509-4998
- first_name: Laurent
full_name: Holtzer, Laurent
last_name: Holtzer
- first_name: Ortrud
full_name: Wartlick, Ortrud
last_name: Wartlick
- first_name: Thomas
full_name: Schmidt, Thomas S
last_name: Schmidt
- first_name: Marcos
full_name: González-Gaitán, Marcos A
last_name: González Gaitán
citation:
ama: Kicheva A, Holtzer L, Wartlick O, Schmidt T, González Gaitán M. Quantitative
imaging of morphogen gradients in drosophila imaginal discs. Cold Spring Harbor
Protocols. 2013;8(5):387-403. doi:10.1101/pdb.top074237
apa: Kicheva, A., Holtzer, L., Wartlick, O., Schmidt, T., & González Gaitán,
M. (2013). Quantitative imaging of morphogen gradients in drosophila imaginal
discs. Cold Spring Harbor Protocols. Cold Spring Harbor Laboratory Press.
https://doi.org/10.1101/pdb.top074237
chicago: Kicheva, Anna, Laurent Holtzer, Ortrud Wartlick, Thomas Schmidt, and Marcos
González Gaitán. “Quantitative Imaging of Morphogen Gradients in Drosophila Imaginal
Discs.” Cold Spring Harbor Protocols. Cold Spring Harbor Laboratory Press,
2013. https://doi.org/10.1101/pdb.top074237.
ieee: A. Kicheva, L. Holtzer, O. Wartlick, T. Schmidt, and M. González Gaitán, “Quantitative
imaging of morphogen gradients in drosophila imaginal discs,” Cold Spring Harbor
Protocols, vol. 8, no. 5. Cold Spring Harbor Laboratory Press, pp. 387–403,
2013.
ista: Kicheva A, Holtzer L, Wartlick O, Schmidt T, González Gaitán M. 2013. Quantitative
imaging of morphogen gradients in drosophila imaginal discs. Cold Spring Harbor
Protocols. 8(5), 387–403.
mla: Kicheva, Anna, et al. “Quantitative Imaging of Morphogen Gradients in Drosophila
Imaginal Discs.” Cold Spring Harbor Protocols, vol. 8, no. 5, Cold Spring
Harbor Laboratory Press, 2013, pp. 387–403, doi:10.1101/pdb.top074237.
short: A. Kicheva, L. Holtzer, O. Wartlick, T. Schmidt, M. González Gaitán, Cold
Spring Harbor Protocols 8 (2013) 387–403.
date_created: 2018-12-11T11:53:41Z
date_published: 2013-05-01T00:00:00Z
date_updated: 2021-01-12T06:52:47Z
day: '01'
doi: 10.1101/pdb.top074237
extern: 1
intvolume: ' 8'
issue: '5'
month: '05'
page: 387 - 403
publication: Cold Spring Harbor Protocols
publication_status: published
publisher: Cold Spring Harbor Laboratory Press
publist_id: '5401'
quality_controlled: 0
status: public
title: Quantitative imaging of morphogen gradients in drosophila imaginal discs
type: journal_article
volume: 8
year: '2013'
...
---
_id: '2970'
abstract:
- lang: eng
text: Morphogen gradients regulate the patterning and growth of many tissues, hence
a key question is how they are established and maintained during development.
Theoretical descriptions have helped to explain how gradient shape is controlled
by the rates of morphogen production, spreading and degradation. These effective
rates have been measured using fluorescence recovery after photobleaching (FRAP)
and photoactivation. To unravel which molecular events determine the effective
rates, such tissue-level assays have been combined with genetic analysis, high-resolution
assays, and models that take into account interactions with receptors, extracellular
components and trafficking. Nevertheless, because of the natural and experimental
data variability, and the underlying assumptions of transport models, it remains
challenging to conclusively distinguish between cellular mechanisms.
acknowledgement: AK is currently supported by an MRC CDF. MGG and OW were supported
by the Swiss National Science Foundation, grants from the Swiss SystemsX.ch initiative,
LipidX-2008/011, an ERC advanced investigator grant and the Polish-Swiss research
program.
author:
- first_name: Anna
full_name: Kicheva, Anna
id: 3959A2A0-F248-11E8-B48F-1D18A9856A87
last_name: Kicheva
orcid: 0000-0003-4509-4998
- first_name: Mark Tobias
full_name: Bollenbach, Mark Tobias
id: 3E6DB97A-F248-11E8-B48F-1D18A9856A87
last_name: Bollenbach
orcid: 0000-0003-4398-476X
- first_name: Ortrud
full_name: Wartlick, Ortrud
last_name: Wartlick
- first_name: Frank
full_name: Julicher, Frank
last_name: Julicher
- first_name: Marcos
full_name: Gonzalez Gaitan, Marcos
last_name: Gonzalez Gaitan
citation:
ama: 'Kicheva A, Bollenbach MT, Wartlick O, Julicher F, Gonzalez Gaitan M. Investigating
the principles of morphogen gradient formation: from tissues to cells. Current
Opinion in Genetics & Development. 2012;22(6):527-532. doi:10.1016/j.gde.2012.08.004'
apa: 'Kicheva, A., Bollenbach, M. T., Wartlick, O., Julicher, F., & Gonzalez
Gaitan, M. (2012). Investigating the principles of morphogen gradient formation:
from tissues to cells. Current Opinion in Genetics & Development. Elsevier.
https://doi.org/10.1016/j.gde.2012.08.004'
chicago: 'Kicheva, Anna, Mark Tobias Bollenbach, Ortrud Wartlick, Frank Julicher,
and Marcos Gonzalez Gaitan. “Investigating the Principles of Morphogen Gradient
Formation: From Tissues to Cells.” Current Opinion in Genetics & Development.
Elsevier, 2012. https://doi.org/10.1016/j.gde.2012.08.004.'
ieee: 'A. Kicheva, M. T. Bollenbach, O. Wartlick, F. Julicher, and M. Gonzalez Gaitan,
“Investigating the principles of morphogen gradient formation: from tissues to
cells,” Current Opinion in Genetics & Development, vol. 22, no. 6.
Elsevier, pp. 527–532, 2012.'
ista: 'Kicheva A, Bollenbach MT, Wartlick O, Julicher F, Gonzalez Gaitan M. 2012.
Investigating the principles of morphogen gradient formation: from tissues to
cells. Current Opinion in Genetics & Development. 22(6), 527–532.'
mla: 'Kicheva, Anna, et al. “Investigating the Principles of Morphogen Gradient
Formation: From Tissues to Cells.” Current Opinion in Genetics & Development,
vol. 22, no. 6, Elsevier, 2012, pp. 527–32, doi:10.1016/j.gde.2012.08.004.'
short: A. Kicheva, M.T. Bollenbach, O. Wartlick, F. Julicher, M. Gonzalez Gaitan,
Current Opinion in Genetics & Development 22 (2012) 527–532.
date_created: 2018-12-11T12:00:37Z
date_published: 2012-12-01T00:00:00Z
date_updated: 2021-01-12T07:40:09Z
day: '01'
department:
- _id: ToBo
doi: 10.1016/j.gde.2012.08.004
intvolume: ' 22'
issue: '6'
language:
- iso: eng
month: '12'
oa_version: None
page: 527 - 532
publication: Current Opinion in Genetics & Development
publication_status: published
publisher: Elsevier
publist_id: '3739'
quality_controlled: '1'
scopus_import: 1
status: public
title: 'Investigating the principles of morphogen gradient formation: from tissues
to cells'
type: journal_article
user_id: 3E5EF7F0-F248-11E8-B48F-1D18A9856A87
volume: 22
year: '2012'
...
---
_id: '1725'
abstract:
- lang: eng
text: The spatial organization of cell fates during development involves the interpretation
of morphogen gradients by cellular signaling cascades and transcriptional networks.
Recent studies use biophysical models, genetics, and quantitative imaging to unravel
how tissue-level morphogen behavior arises from subcellular events. Moreover,
data from several systems show that morphogen gradients, downstream signaling,
and the activity of cell-intrinsic transcriptional networks change dynamically
during pattern formation. Studies from Drosophila and now also vertebrates suggest
that transcriptional network dynamics are central to the generation of gene expression
patterns. Together, this leads to the view that pattern formation is an emergent
behavior that results from the coordination of events occurring across molecular,
cellular, and tissue scales. The development of novel approaches to study this
complex process remains a challenge.
acknowledgement: 'Funding provided by the Medical Research Council (UK). '
author:
- first_name: Anna
full_name: Anna Kicheva
id: 3959A2A0-F248-11E8-B48F-1D18A9856A87
last_name: Kicheva
orcid: 0000-0003-4509-4998
- first_name: Michael
full_name: Cohen, Michael H
last_name: Cohen
- first_name: James
full_name: Briscoe, James
last_name: Briscoe
citation:
ama: 'Kicheva A, Cohen M, Briscoe J. Developmental pattern formation: Insights from
physics and biology. Science. 2012;338(6104):210-212. doi:10.1126/science.1225182'
apa: 'Kicheva, A., Cohen, M., & Briscoe, J. (2012). Developmental pattern formation:
Insights from physics and biology. Science. American Association for the
Advancement of Science. https://doi.org/10.1126/science.1225182'
chicago: 'Kicheva, Anna, Michael Cohen, and James Briscoe. “Developmental Pattern
Formation: Insights from Physics and Biology.” Science. American Association
for the Advancement of Science, 2012. https://doi.org/10.1126/science.1225182.'
ieee: 'A. Kicheva, M. Cohen, and J. Briscoe, “Developmental pattern formation: Insights
from physics and biology,” Science, vol. 338, no. 6104. American Association
for the Advancement of Science, pp. 210–212, 2012.'
ista: 'Kicheva A, Cohen M, Briscoe J. 2012. Developmental pattern formation: Insights
from physics and biology. Science. 338(6104), 210–212.'
mla: 'Kicheva, Anna, et al. “Developmental Pattern Formation: Insights from Physics
and Biology.” Science, vol. 338, no. 6104, American Association for the
Advancement of Science, 2012, pp. 210–12, doi:10.1126/science.1225182.'
short: A. Kicheva, M. Cohen, J. Briscoe, Science 338 (2012) 210–212.
date_created: 2018-12-11T11:53:40Z
date_published: 2012-10-12T00:00:00Z
date_updated: 2021-01-12T06:52:47Z
day: '12'
doi: 10.1126/science.1225182
extern: 1
intvolume: ' 338'
issue: '6104'
month: '10'
page: 210 - 212
publication: Science
publication_status: published
publisher: American Association for the Advancement of Science
publist_id: '5404'
quality_controlled: 0
status: public
title: 'Developmental pattern formation: Insights from physics and biology'
type: journal_article
volume: 338
year: '2012'
...
---
_id: '1723'
abstract:
- lang: eng
text: The emergence of differences in the arrangement of cells is the first step
towards the establishment of many organs. Understanding this process is limited
by the lack of systematic characterization of epithelial organisation. Here we
apply network theory at the scale of individual cells to uncover patterns in cell-to-cell
contacts that govern epithelial organisation. We provide an objective characterisation
of epithelia using network representation, where cells are nodes and cell contacts
are links. The features of individual cells, together with attributes of the cellular
network, produce a defining signature that distinguishes epithelia from different
organs, species, developmental stages and genetic conditions. The approach permits
characterization, quantification and classification of normal and perturbed epithelia,
and establishes a framework for understanding molecular mechanisms that underpin
the architecture of complex tissues.
acknowledgement: We acknowledge the MRC for funding, M.M.B. acknowledges Darwin College,
EMBO YIP and Schlumberger Ltd for support. L.M.E. is funded by the Marie Curie and
the EMBO fellowships. L.d.F.C. is grateful to FAPESP (05/00587-5) and CNPq (301303/06-1)
for financial support. Part of this work was performed during a Visiting Scholarship
to L.d.F.C. from St Catharine's College, University of Cambridge. J.B. is supported
by the MRC (UK) and A.K. by a FEBS fellowship
author:
- first_name: Luis
full_name: Escudero, Luis M
last_name: Escudero
- first_name: Luciano
full_name: Costa, Luciano
last_name: Costa
- first_name: Anna
full_name: Anna Kicheva
id: 3959A2A0-F248-11E8-B48F-1D18A9856A87
last_name: Kicheva
orcid: 0000-0003-4509-4998
- first_name: James
full_name: Briscoe, James
last_name: Briscoe
- first_name: Matthew
full_name: Freeman, Matthew
last_name: Freeman
- first_name: Madan
full_name: Babu, Madan M
last_name: Babu
citation:
ama: Escudero L, Costa L, Kicheva A, Briscoe J, Freeman M, Babu M. Epithelial organisation
revealed by a network of cellular contacts. Nature Communications. 2011;2(1).
doi:10.1038/ncomms1536
apa: Escudero, L., Costa, L., Kicheva, A., Briscoe, J., Freeman, M., & Babu,
M. (2011). Epithelial organisation revealed by a network of cellular contacts.
Nature Communications. Nature Publishing Group. https://doi.org/10.1038/ncomms1536
chicago: Escudero, Luis, Luciano Costa, Anna Kicheva, James Briscoe, Matthew Freeman,
and Madan Babu. “Epithelial Organisation Revealed by a Network of Cellular Contacts.”
Nature Communications. Nature Publishing Group, 2011. https://doi.org/10.1038/ncomms1536.
ieee: L. Escudero, L. Costa, A. Kicheva, J. Briscoe, M. Freeman, and M. Babu, “Epithelial
organisation revealed by a network of cellular contacts,” Nature Communications,
vol. 2, no. 1. Nature Publishing Group, 2011.
ista: Escudero L, Costa L, Kicheva A, Briscoe J, Freeman M, Babu M. 2011. Epithelial
organisation revealed by a network of cellular contacts. Nature Communications.
2(1).
mla: Escudero, Luis, et al. “Epithelial Organisation Revealed by a Network of Cellular
Contacts.” Nature Communications, vol. 2, no. 1, Nature Publishing Group,
2011, doi:10.1038/ncomms1536.
short: L. Escudero, L. Costa, A. Kicheva, J. Briscoe, M. Freeman, M. Babu, Nature
Communications 2 (2011).
date_created: 2018-12-11T11:53:40Z
date_published: 2011-01-01T00:00:00Z
date_updated: 2021-01-12T06:52:46Z
day: '01'
doi: 10.1038/ncomms1536
extern: 1
intvolume: ' 2'
issue: '1'
month: '01'
publication: Nature Communications
publication_status: published
publisher: Nature Publishing Group
publist_id: '5405'
quality_controlled: 0
status: public
title: Epithelial organisation revealed by a network of cellular contacts
type: journal_article
volume: 2
year: '2011'
...
---
_id: '1724'
abstract:
- lang: eng
text: Morphogens, such as Decapentaplegic (Dpp) in the fly imaginal discs, form
graded concentration profiles that control patterning and growth of developing
organs. In the imaginal discs, proliferative growth is homogeneous in space, posing
the conundrum of how morphogen concentration gradients could control position-independent
growth. To understand the mechanism of proliferation control by the Dpp gradient,
we quantified Dpp concentration and signaling levels during wing disc growth.
Both Dpp concentration and signaling gradients scale with tissue size during development.
On average, cells divide when Dpp signaling levels have increased by 50%. Our
observations are consistent with a growth control mechanism based on temporal
changes of cellular morphogen signaling levels. For a scaling gradient, this mechanism
generates position-independent growth rates.
acknowledgement: P.M., T.B., and F.J. were supported by the Max-Planck-Gesellschaft.
O.W., A.K., C.S., and M.G.-G. were supported by Geneva University and by European
Research Council advanced investigator grant (SARA), SystemsX (LipidX), Swiss National
Science Foundation (SNF), National Centre of Competence in Research (NCCR) chemical
biology and Frontiers in Genetics and R'equip grants
author:
- first_name: Ortrud
full_name: Wartlick, Ortrud
last_name: Wartlick
- first_name: Peer
full_name: Mumcu, Peer
last_name: Mumcu
- first_name: Anna
full_name: Anna Kicheva
id: 3959A2A0-F248-11E8-B48F-1D18A9856A87
last_name: Kicheva
orcid: 0000-0003-4509-4998
- first_name: Thomas
full_name: Bittig, Thomas
last_name: Bittig
- first_name: Carole
full_name: Seum, Carole
last_name: Seum
- first_name: Frank
full_name: Jülicher, Frank
last_name: Jülicher
- first_name: Marcos
full_name: González-Gaitán, Marcos A
last_name: González Gaitán
citation:
ama: Wartlick O, Mumcu P, Kicheva A, et al. Dynamics of Dpp signaling and proliferation
control. Science. 2011;331(6021):1154-1159. doi:10.1126/science.1200037
apa: Wartlick, O., Mumcu, P., Kicheva, A., Bittig, T., Seum, C., Jülicher, F., &
González Gaitán, M. (2011). Dynamics of Dpp signaling and proliferation control.
Science. American Association for the Advancement of Science. https://doi.org/10.1126/science.1200037
chicago: Wartlick, Ortrud, Peer Mumcu, Anna Kicheva, Thomas Bittig, Carole Seum,
Frank Jülicher, and Marcos González Gaitán. “Dynamics of Dpp Signaling and Proliferation
Control.” Science. American Association for the Advancement of Science,
2011. https://doi.org/10.1126/science.1200037.
ieee: O. Wartlick et al., “Dynamics of Dpp signaling and proliferation control,”
Science, vol. 331, no. 6021. American Association for the Advancement of
Science, pp. 1154–1159, 2011.
ista: Wartlick O, Mumcu P, Kicheva A, Bittig T, Seum C, Jülicher F, González Gaitán
M. 2011. Dynamics of Dpp signaling and proliferation control. Science. 331(6021),
1154–1159.
mla: Wartlick, Ortrud, et al. “Dynamics of Dpp Signaling and Proliferation Control.”
Science, vol. 331, no. 6021, American Association for the Advancement of
Science, 2011, pp. 1154–59, doi:10.1126/science.1200037.
short: O. Wartlick, P. Mumcu, A. Kicheva, T. Bittig, C. Seum, F. Jülicher, M. González
Gaitán, Science 331 (2011) 1154–1159.
date_created: 2018-12-11T11:53:40Z
date_published: 2011-03-04T00:00:00Z
date_updated: 2021-01-12T06:52:46Z
day: '04'
doi: 10.1126/science.1200037
extern: 1
intvolume: ' 331'
issue: '6021'
month: '03'
page: 1154 - 1159
publication: Science
publication_status: published
publisher: American Association for the Advancement of Science
publist_id: '5406'
quality_controlled: 0
status: public
title: Dynamics of Dpp signaling and proliferation control
type: journal_article
volume: 331
year: '2011'
...