[{"related_material":{"record":[{"status":"public","id":"13081","relation":"dissertation_contains"}]},"acknowledgement":"We thank S. Hippenmeyer for the reagents and C. P. Heisenberg, J. Briscoe and K. Page for comments on the manuscript. This work was supported by IST Austria; the European Research Council under Horizon 2020 research and innovation programme grant no. 680037 and Horizon Europe grant 101044579 (A.K.); Austrian Science Fund (FWF): F78 (Stem Cell Modulation) (A.K.); ISTFELLOW postdoctoral program (A.S.); Narodowe Centrum Nauki, Poland SONATA, 2017/26/D/NZ2/00454 (M.Z.); and the Polish National Agency for Academic Exchange (M.Z.).","citation":{"ama":"Bocanegra L, Singh A, Hannezo EB, Zagórski MP, Kicheva A. Cell cycle dynamics control fluidity of the developing mouse neuroepithelium. <i>Nature Physics</i>. 2023;19:1050-1058. doi:<a href=\"https://doi.org/10.1038/s41567-023-01977-w\">10.1038/s41567-023-01977-w</a>","apa":"Bocanegra, L., Singh, A., Hannezo, E. B., Zagórski, M. P., &#38; Kicheva, A. (2023). Cell cycle dynamics control fluidity of the developing mouse neuroepithelium. <i>Nature Physics</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41567-023-01977-w\">https://doi.org/10.1038/s41567-023-01977-w</a>","chicago":"Bocanegra, Laura, Amrita Singh, Edouard B Hannezo, Marcin P Zagórski, and Anna Kicheva. “Cell Cycle Dynamics Control Fluidity of the Developing Mouse Neuroepithelium.” <i>Nature Physics</i>. Springer Nature, 2023. <a href=\"https://doi.org/10.1038/s41567-023-01977-w\">https://doi.org/10.1038/s41567-023-01977-w</a>.","short":"L. Bocanegra, A. Singh, E.B. Hannezo, M.P. Zagórski, A. Kicheva, Nature Physics 19 (2023) 1050–1058.","ista":"Bocanegra L, Singh A, Hannezo EB, Zagórski MP, Kicheva A. 2023. Cell cycle dynamics control fluidity of the developing mouse neuroepithelium. Nature Physics. 19, 1050–1058.","ieee":"L. Bocanegra, A. Singh, E. B. Hannezo, M. P. Zagórski, and A. Kicheva, “Cell cycle dynamics control fluidity of the developing mouse neuroepithelium,” <i>Nature Physics</i>, vol. 19. Springer Nature, pp. 1050–1058, 2023.","mla":"Bocanegra, Laura, et al. “Cell Cycle Dynamics Control Fluidity of the Developing Mouse Neuroepithelium.” <i>Nature Physics</i>, vol. 19, Springer Nature, 2023, pp. 1050–58, doi:<a href=\"https://doi.org/10.1038/s41567-023-01977-w\">10.1038/s41567-023-01977-w</a>."},"doi":"10.1038/s41567-023-01977-w","quality_controlled":"1","ec_funded":1,"has_accepted_license":"1","intvolume":"        19","year":"2023","publication_identifier":{"eissn":["1745-2481"],"issn":["1745-2473"]},"language":[{"iso":"eng"}],"isi":1,"page":"1050-1058","license":"https://creativecommons.org/licenses/by/4.0/","external_id":{"isi":["000964029300003"]},"ddc":["570"],"oa":1,"abstract":[{"text":"As developing tissues grow in size and undergo morphogenetic changes, their material properties may be altered. Such changes result from tension dynamics at cell contacts or cellular jamming. Yet, in many cases, the cellular mechanisms controlling the physical state of growing tissues are unclear. We found that at early developmental stages, the epithelium in the developing mouse spinal cord maintains both high junctional tension and high fluidity. This is achieved via a mechanism in which interkinetic nuclear movements generate cell area dynamics that drive extensive cell rearrangements. Over time, the cell proliferation rate declines, effectively solidifying the tissue. Thus, unlike well-studied jamming transitions, the solidification uncovered here resembles a glass transition that depends on the dynamical stresses generated by proliferation and differentiation. Our finding that the fluidity of developing epithelia is linked to interkinetic nuclear movements and the dynamics of growth is likely to be relevant to multiple developing tissues.","lang":"eng"}],"file":[{"file_name":"2023_NaturePhysics_Boncanegra.pdf","relation":"main_file","success":1,"content_type":"application/pdf","access_level":"open_access","date_created":"2023-10-04T11:13:28Z","file_id":"14392","date_updated":"2023-10-04T11:13:28Z","creator":"dernst","checksum":"858225a4205b74406e5045006cdd853f","file_size":5532285}],"author":[{"last_name":"Bocanegra","first_name":"Laura","id":"4896F754-F248-11E8-B48F-1D18A9856A87","full_name":"Bocanegra, Laura"},{"first_name":"Amrita","id":"76250f9f-3a21-11eb-9a80-a6180a0d7958","last_name":"Singh","full_name":"Singh, Amrita"},{"id":"3A9DB764-F248-11E8-B48F-1D18A9856A87","first_name":"Edouard B","last_name":"Hannezo","orcid":"0000-0001-6005-1561","full_name":"Hannezo, Edouard B"},{"first_name":"Marcin P","id":"343DA0DC-F248-11E8-B48F-1D18A9856A87","last_name":"Zagórski","full_name":"Zagórski, Marcin P","orcid":"0000-0001-7896-7762"},{"orcid":"0000-0003-4509-4998","full_name":"Kicheva, Anna","first_name":"Anna","id":"3959A2A0-F248-11E8-B48F-1D18A9856A87","last_name":"Kicheva"}],"department":[{"_id":"EdHa"},{"_id":"AnKi"}],"project":[{"grant_number":"680037","call_identifier":"H2020","name":"Coordination of Patterning And Growth In the Spinal Cord","_id":"B6FC0238-B512-11E9-945C-1524E6697425"},{"grant_number":"101044579","name":"Mechanisms of tissue size regulation in spinal cord development","_id":"bd7e737f-d553-11ed-ba76-d69ffb5ee3aa"},{"grant_number":"F07802","name":"Morphogen control of growth and pattern in the spinal cord","_id":"059DF620-7A3F-11EA-A408-12923DDC885E"},{"grant_number":"291734","call_identifier":"FP7","_id":"25681D80-B435-11E9-9278-68D0E5697425","name":"International IST Postdoc Fellowship Programme"}],"oa_version":"Published Version","date_created":"2023-04-16T22:01:09Z","type":"journal_article","_id":"12837","article_processing_charge":"No","publication":"Nature Physics","file_date_updated":"2023-10-04T11:13:28Z","title":"Cell cycle dynamics control fluidity of the developing mouse neuroepithelium","tmp":{"image":"/images/cc_by.png","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"volume":19,"status":"public","day":"01","scopus_import":"1","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","publication_status":"published","publisher":"Springer Nature","date_updated":"2023-10-04T11:14:05Z","date_published":"2023-07-01T00:00:00Z","month":"07","article_type":"original"},{"article_type":"original","date_published":"2023-09-01T00:00:00Z","month":"09","publication_status":"published","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","date_updated":"2024-01-29T11:07:47Z","publisher":"Elsevier","scopus_import":"1","day":"01","tmp":{"image":"/images/cc_by_nc_nd.png","legal_code_url":"https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode","short":"CC BY-NC-ND (4.0)","name":"Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)"},"title":"Control of tissue dimensions in the developing neural tube and somites","volume":35,"status":"public","article_number":"100459","date_created":"2023-06-18T22:00:46Z","oa_version":"Published Version","project":[{"grant_number":"101044579","name":"Mechanisms of tissue size regulation in spinal cord development","_id":"bd7e737f-d553-11ed-ba76-d69ffb5ee3aa"},{"grant_number":"F07802","name":"Morphogen control of growth and pattern in the spinal cord","_id":"059DF620-7A3F-11EA-A408-12923DDC885E"},{"_id":"9B9B39FA-BA93-11EA-9121-9846C619BF3A","name":"The regulatory logic of pattern formation in the vertebrate dorsal neural tube","grant_number":"SC19-011"}],"publication":"Current Opinion in Systems Biology","file_date_updated":"2024-01-29T11:06:45Z","type":"journal_article","_id":"13136","article_processing_charge":"Yes (via OA deal)","author":[{"full_name":"Minchington, Thomas","last_name":"Minchington","first_name":"Thomas","id":"7d1648cb-19e9-11eb-8e7a-f8c037fb3e3f"},{"last_name":"Rus","id":"4D9EC9B6-F248-11E8-B48F-1D18A9856A87","first_name":"Stefanie","full_name":"Rus, Stefanie","orcid":"0000-0001-8703-1093"},{"full_name":"Kicheva, Anna","orcid":"0000-0003-4509-4998","id":"3959A2A0-F248-11E8-B48F-1D18A9856A87","first_name":"Anna","last_name":"Kicheva"}],"department":[{"_id":"AnKi"}],"abstract":[{"text":"Despite its fundamental importance for development, the question of how organs achieve their correct size and shape is poorly understood. This complex process requires coordination between the generation of cell mass and the morphogenetic mechanisms that sculpt tissues. These processes are regulated by morphogen signalling pathways and mechanical forces. Yet, in many systems, it is unclear how biochemical and mechanical signalling are quantitatively interpreted to determine the behaviours of individual cells and how they contribute to growth and morphogenesis at the tissue scale. In this review, we discuss the development of the vertebrate neural tube and somites as an example of the state of knowledge, as well as the challenges in understanding the mechanisms of tissue size control in vertebrate organogenesis. We highlight how the recent advances in stem cell differentiation and organoid approaches can be harnessed to provide new insights into this question.","lang":"eng"}],"ddc":["570"],"oa":1,"file":[{"checksum":"8a75c4e29fd9b62e3c50663c2265b173","file_size":598842,"creator":"dernst","date_updated":"2024-01-29T11:06:45Z","file_id":"14896","access_level":"open_access","date_created":"2024-01-29T11:06:45Z","content_type":"application/pdf","success":1,"file_name":"2023_CurrOpSystBioloy_Minchington.pdf","relation":"main_file"}],"license":"https://creativecommons.org/licenses/by-nc-nd/4.0/","year":"2023","publication_identifier":{"eissn":["2452-3100"]},"language":[{"iso":"eng"}],"has_accepted_license":"1","intvolume":"        35","quality_controlled":"1","doi":"10.1016/j.coisb.2023.100459","citation":{"ama":"Minchington T, Rus S, Kicheva A. Control of tissue dimensions in the developing neural tube and somites. <i>Current Opinion in Systems Biology</i>. 2023;35. doi:<a href=\"https://doi.org/10.1016/j.coisb.2023.100459\">10.1016/j.coisb.2023.100459</a>","ista":"Minchington T, Rus S, Kicheva A. 2023. Control of tissue dimensions in the developing neural tube and somites. Current Opinion in Systems Biology. 35, 100459.","ieee":"T. Minchington, S. Rus, and A. Kicheva, “Control of tissue dimensions in the developing neural tube and somites,” <i>Current Opinion in Systems Biology</i>, vol. 35. Elsevier, 2023.","mla":"Minchington, Thomas, et al. “Control of Tissue Dimensions in the Developing Neural Tube and Somites.” <i>Current Opinion in Systems Biology</i>, vol. 35, 100459, Elsevier, 2023, doi:<a href=\"https://doi.org/10.1016/j.coisb.2023.100459\">10.1016/j.coisb.2023.100459</a>.","apa":"Minchington, T., Rus, S., &#38; Kicheva, A. (2023). Control of tissue dimensions in the developing neural tube and somites. <i>Current Opinion in Systems Biology</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.coisb.2023.100459\">https://doi.org/10.1016/j.coisb.2023.100459</a>","short":"T. Minchington, S. Rus, A. Kicheva, Current Opinion in Systems Biology 35 (2023).","chicago":"Minchington, Thomas, Stefanie Rus, and Anna Kicheva. “Control of Tissue Dimensions in the Developing Neural Tube and Somites.” <i>Current Opinion in Systems Biology</i>. Elsevier, 2023. <a href=\"https://doi.org/10.1016/j.coisb.2023.100459\">https://doi.org/10.1016/j.coisb.2023.100459</a>."},"acknowledgement":"We thank J. Briscoe for comments on the manuscript. Work in the AK lab is supported by ISTA, the European Research Council under Horizon Europe: grant 101044579, and Austrian Science Fund (FWF): F78 (Stem Cell Modulation). SR is supported by Gesellschaft für Forschungsförderung Niederösterreich m.b.H. fellowship SC19-011."},{"day":"16","status":"public","volume":39,"tmp":{"image":"/images/cc_by.png","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"title":"Control of tissue development by morphogens","_id":"14484","type":"journal_article","article_processing_charge":"Yes (in subscription journal)","file_date_updated":"2023-11-06T09:47:50Z","publication":"Annual Review of Cell and Developmental Biology","project":[{"_id":"B6FC0238-B512-11E9-945C-1524E6697425","name":"Coordination of Patterning And Growth In the Spinal Cord","call_identifier":"H2020","grant_number":"680037"},{"grant_number":"101044579","_id":"bd7e737f-d553-11ed-ba76-d69ffb5ee3aa","name":"Mechanisms of tissue size regulation in spinal cord development"},{"grant_number":"F07802","name":"Morphogen control of growth and pattern in the spinal cord","_id":"059DF620-7A3F-11EA-A408-12923DDC885E"}],"oa_version":"Published Version","date_created":"2023-11-05T23:00:53Z","department":[{"_id":"AnKi"}],"author":[{"id":"3959A2A0-F248-11E8-B48F-1D18A9856A87","first_name":"Anna","last_name":"Kicheva","full_name":"Kicheva, Anna","orcid":"0000-0003-4509-4998"},{"last_name":"Briscoe","first_name":"James","full_name":"Briscoe, James"}],"date_published":"2023-10-16T00:00:00Z","month":"10","article_type":"review","publisher":"Annual Reviews","date_updated":"2023-11-06T09:56:24Z","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","publication_status":"published","scopus_import":"1","publication_identifier":{"eissn":["1530-8995"],"issn":["1081-0706"]},"language":[{"iso":"eng"}],"year":"2023","pmid":1,"intvolume":"        39","has_accepted_license":"1","citation":{"ama":"Kicheva A, Briscoe J. Control of tissue development by morphogens. <i>Annual Review of Cell and Developmental Biology</i>. 2023;39:91-121. doi:<a href=\"https://doi.org/10.1146/annurev-cellbio-020823-011522\">10.1146/annurev-cellbio-020823-011522</a>","ieee":"A. Kicheva and J. Briscoe, “Control of tissue development by morphogens,” <i>Annual Review of Cell and Developmental Biology</i>, vol. 39. Annual Reviews, pp. 91–121, 2023.","ista":"Kicheva A, Briscoe J. 2023. Control of tissue development by morphogens. Annual Review of Cell and Developmental Biology. 39, 91–121.","mla":"Kicheva, Anna, and James Briscoe. “Control of Tissue Development by Morphogens.” <i>Annual Review of Cell and Developmental Biology</i>, vol. 39, Annual Reviews, 2023, pp. 91–121, doi:<a href=\"https://doi.org/10.1146/annurev-cellbio-020823-011522\">10.1146/annurev-cellbio-020823-011522</a>.","apa":"Kicheva, A., &#38; Briscoe, J. (2023). Control of tissue development by morphogens. <i>Annual Review of Cell and Developmental Biology</i>. Annual Reviews. <a href=\"https://doi.org/10.1146/annurev-cellbio-020823-011522\">https://doi.org/10.1146/annurev-cellbio-020823-011522</a>","short":"A. Kicheva, J. Briscoe, Annual Review of Cell and Developmental Biology 39 (2023) 91–121.","chicago":"Kicheva, Anna, and James Briscoe. “Control of Tissue Development by Morphogens.” <i>Annual Review of Cell and Developmental Biology</i>. Annual Reviews, 2023. <a href=\"https://doi.org/10.1146/annurev-cellbio-020823-011522\">https://doi.org/10.1146/annurev-cellbio-020823-011522</a>."},"doi":"10.1146/annurev-cellbio-020823-011522","quality_controlled":"1","ec_funded":1,"acknowledgement":"We are grateful to Zena Hadjivasiliou for comments on this article. A.K. is supported by grants from the European Research Council under the European Union (EU) Horizon 2020 research and innovation program (680037) and Horizon Europe (101044579), and the Austrian Science Fund (F78) (Stem Cell Modulation). J.B. is supported by the Francis Crick Institute, which receives its core funding from Cancer Research UK (CC001051), the UK Medical Research Council (CC001051), and the Wellcome Trust (CC001051), and by a grant from the European Research Council under the EU Horizon 2020 research and innovation program (742138).","file":[{"access_level":"open_access","date_created":"2023-11-06T09:47:50Z","file_id":"14491","relation":"main_file","file_name":"2023_AnnualReviews_Kicheva.pdf","content_type":"application/pdf","success":1,"creator":"dernst","file_size":434819,"checksum":"461726014cf5907010afbd418d3c13ec","date_updated":"2023-11-06T09:47:50Z"}],"ddc":["570"],"oa":1,"abstract":[{"lang":"eng","text":"Intercellular signaling molecules, known as morphogens, act at a long range in developing tissues to provide spatial information and control properties such as cell fate and tissue growth. The production, transport, and removal of morphogens shape their concentration profiles in time and space. Downstream signaling cascades and gene regulatory networks within cells then convert the spatiotemporal morphogen profiles into distinct cellular responses. Current challenges are to understand the diverse molecular and cellular mechanisms underlying morphogen gradient formation, as well as the logic of downstream regulatory circuits involved in morphogen interpretation. This knowledge, combining experimental and theoretical results, is essential to understand emerging properties of morphogen-controlled systems, such as robustness and scaling."}],"external_id":{"pmid":["37418774"]},"page":"91-121"},{"publisher":"IOP Publishing","date_updated":"2023-08-08T13:15:46Z","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","publication_status":"published","month":"04","date_published":"2021-04-14T00:00:00Z","article_type":"original","scopus_import":"1","article_number":"041501","status":"public","tmp":{"image":"/images/cc_by.png","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"volume":18,"title":"Roadmap for the multiscale coupling of biochemical and mechanical signals during development","day":"14","department":[{"_id":"AnKi"},{"_id":"EdHa"}],"author":[{"first_name":"Pierre François","last_name":"Lenne","full_name":"Lenne, Pierre François"},{"last_name":"Munro","first_name":"Edwin","full_name":"Munro, Edwin"},{"full_name":"Heemskerk, Idse","first_name":"Idse","last_name":"Heemskerk"},{"last_name":"Warmflash","first_name":"Aryeh","full_name":"Warmflash, Aryeh"},{"full_name":"Bocanegra, Laura","last_name":"Bocanegra","first_name":"Laura","id":"4896F754-F248-11E8-B48F-1D18A9856A87"},{"last_name":"Kishi","id":"3065DFC4-F248-11E8-B48F-1D18A9856A87","first_name":"Kasumi","full_name":"Kishi, Kasumi"},{"orcid":"0000-0003-4509-4998","full_name":"Kicheva, Anna","last_name":"Kicheva","id":"3959A2A0-F248-11E8-B48F-1D18A9856A87","first_name":"Anna"},{"first_name":"Yuchen","last_name":"Long","full_name":"Long, Yuchen"},{"full_name":"Fruleux, Antoine","last_name":"Fruleux","first_name":"Antoine"},{"full_name":"Boudaoud, Arezki","first_name":"Arezki","last_name":"Boudaoud"},{"first_name":"Timothy E.","last_name":"Saunders","full_name":"Saunders, Timothy E."},{"full_name":"Caldarelli, Paolo","first_name":"Paolo","last_name":"Caldarelli"},{"last_name":"Michaut","first_name":"Arthur","full_name":"Michaut, Arthur"},{"first_name":"Jerome","last_name":"Gros","full_name":"Gros, Jerome"},{"full_name":"Maroudas-Sacks, Yonit","first_name":"Yonit","last_name":"Maroudas-Sacks"},{"last_name":"Keren","first_name":"Kinneret","full_name":"Keren, Kinneret"},{"id":"3A9DB764-F248-11E8-B48F-1D18A9856A87","first_name":"Edouard B","last_name":"Hannezo","full_name":"Hannezo, Edouard B","orcid":"0000-0001-6005-1561"},{"full_name":"Gartner, Zev J.","first_name":"Zev J.","last_name":"Gartner"},{"last_name":"Stormo","first_name":"Benjamin","full_name":"Stormo, Benjamin"},{"full_name":"Gladfelter, Amy","last_name":"Gladfelter","first_name":"Amy"},{"first_name":"Alan","last_name":"Rodrigues","full_name":"Rodrigues, Alan"},{"full_name":"Shyer, Amy","last_name":"Shyer","first_name":"Amy"},{"full_name":"Minc, Nicolas","last_name":"Minc","first_name":"Nicolas"},{"first_name":"Jean Léon","last_name":"Maître","full_name":"Maître, Jean Léon"},{"first_name":"Stefano","last_name":"Di Talia","full_name":"Di Talia, Stefano"},{"last_name":"Khamaisi","first_name":"Bassma","full_name":"Khamaisi, Bassma"},{"last_name":"Sprinzak","first_name":"David","full_name":"Sprinzak, David"},{"first_name":"Sham","last_name":"Tlili","full_name":"Tlili, Sham"}],"_id":"9349","type":"journal_article","issue":"4","article_processing_charge":"No","file_date_updated":"2021-04-27T08:38:35Z","publication":"Physical biology","project":[{"call_identifier":"H2020","grant_number":"680037","name":"Coordination of Patterning And Growth In the Spinal Cord","_id":"B6FC0238-B512-11E9-945C-1524E6697425"},{"call_identifier":"FWF","grant_number":"P31639","name":"Active mechano-chemical description of the cell cytoskeleton","_id":"268294B6-B435-11E9-9278-68D0E5697425"},{"grant_number":"851288","call_identifier":"H2020","name":"Design Principles of Branching Morphogenesis","_id":"05943252-7A3F-11EA-A408-12923DDC885E"}],"oa_version":"Published Version","date_created":"2021-04-25T22:01:29Z","file":[{"date_updated":"2021-04-27T08:38:35Z","file_size":6296324,"checksum":"4f52082549d3561c4c15d4d8d84ca5d8","creator":"cziletti","content_type":"application/pdf","success":1,"relation":"main_file","file_name":"2021_PhysBio_Lenne.pdf","file_id":"9355","access_level":"open_access","date_created":"2021-04-27T08:38:35Z"}],"ddc":["570"],"oa":1,"abstract":[{"text":"The way in which interactions between mechanics and biochemistry lead to the emergence of complex cell and tissue organization is an old question that has recently attracted renewed interest from biologists, physicists, mathematicians and computer scientists. Rapid advances in optical physics, microscopy and computational image analysis have greatly enhanced our ability to observe and quantify spatiotemporal patterns of signalling, force generation, deformation, and flow in living cells and tissues. Powerful new tools for genetic, biophysical and optogenetic manipulation are allowing us to perturb the underlying machinery that generates these patterns in increasingly sophisticated ways. Rapid advances in theory and computing have made it possible to construct predictive models that describe how cell and tissue organization and dynamics emerge from the local coupling of biochemistry and mechanics. Together, these advances have opened up a wealth of new opportunities to explore how mechanochemical patterning shapes organismal development. In this roadmap, we present a series of forward-looking case studies on mechanochemical patterning in development, written by scientists working at the interface between the physical and biological sciences, and covering a wide range of spatial and temporal scales, organisms, and modes of development. Together, these contributions highlight the many ways in which the dynamic coupling of mechanics and biochemistry shapes biological dynamics: from mechanoenzymes that sense force to tune their activity and motor output, to collectives of cells in tissues that flow and redistribute biochemical signals during development.","lang":"eng"}],"external_id":{"pmid":["33276350"],"isi":["000640396400001"]},"isi":1,"pmid":1,"intvolume":"        18","has_accepted_license":"1","language":[{"iso":"eng"}],"publication_identifier":{"eissn":["1478-3975"]},"year":"2021","acknowledgement":"The AK group is supported by IST Austria and by the ERC under European Union Horizon 2020 research and innovation programme Grant 680037. Apologies to those whose work could not be mentioned due to limited space. We thank all my lab members, both past and present, for stimulating discussion. This work was funded by a Singapore Ministry of Education Tier 3 Grant, MOE2016-T3-1-005. We thank Francis Corson for continuous discussion and collaboration contributing to these views and for figure 4(A). PC is sponsored by the Institut Pasteur and the European Union's Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie Grant Agreement No. 665807. Research in JG's laboratory is funded by the European Research Council under the European Union's Seventh Framework Programme (FP7/2007-2013)/ERC Grant Agreement No. 337635, Institut Pasteur, CNRS, Cercle FSER, Fondation pour la Recherche Medicale, the Vallee Foundation and the ANR-19-CE-13-0024 Grant. We thank Erez Braun and Alex Mogilner for comments on the manuscript and Niv Ierushalmi for help with figure 5. This project has received funding from the European Union's Horizon 2020 research and innovation programme under Grant Agreement No. ERC-2018-COG Grant 819174-HydraMechanics awarded to KK. EH thanks all lab members, as well as Pierre Recho, Tsuyoshi Hirashima, Diana Pinheiro and Carl-Philip Heisenberg, for fruitful discussions on these topics—and apologize for not being able to cite many very relevant publications due to the strict 10-reference limit. EH acknowledges the support of Austrian Science Fund (FWF) (P 31639) and the European Research Council under the European Union's Horizon 2020 Research and Innovation Programme Grant Agreements (851288). The authors acknowledge the inspiring scientists whose work could not be cited in this perspective due to space constraints; the members of the Gartner Lab for helpful discussions; the Barbara and Gerson Bakar Foundation, the Chan Zuckerberg Biohub Investigators Programme, the National Institute of Health, and the Centre for Cellular Construction, an NSF Science and Technology Centre. The Minc laboratory is currently funded by the CNRS and the European Research Council (CoG Forcaster No. 647073). Research in the lab of J-LM is supported by the Institut Curie, the Centre National de la Recherche Scientifique (CNRS), the Institut National de la Santé Et de la Recherche Médicale (INSERM), and is funded by grants from the ATIP-Avenir programme, the Fondation Schlumberger pour l'Éducation et la Recherche via the Fondation pour la Recherche Médicale, the European Research Council Starting Grant ERC-2017-StG 757557, the European Molecular Biology Organization Young Investigator programme (EMBO YIP), the INSERM transversal programme Human Development Cell Atlas (HuDeCA), Paris Sciences Lettres (PSL) 'nouvelle équipe' and QLife (17-CONV-0005) grants and Labex DEEP (ANR-11-LABX-0044) which are part of the IDEX PSL (ANR-10-IDEX-0001-02). We acknowledge useful discussions with Massimo Vergassola, Sebastian Streichan and my lab members. Work in my laboratory on Drosophila embryogenesis is partly supported by NIH-R01GM122936. The authors acknowledge the support by a grant from the European Research Council (Grant No. 682161). Lenne group is funded by a grant from the 'Investissements d'Avenir' French Government programme managed by the French National Research Agency (ANR-16-CONV-0001) and by the Excellence Initiative of Aix-Marseille University—A*MIDEX, and ANR projects MechaResp (ANR-17-CE13-0032) and AdGastrulo (ANR-19-CE13-0022).","related_material":{"record":[{"relation":"dissertation_contains","id":"13081","status":"public"}]},"doi":"10.1088/1478-3975/abd0db","citation":{"ama":"Lenne PF, Munro E, Heemskerk I, et al. Roadmap for the multiscale coupling of biochemical and mechanical signals during development. <i>Physical biology</i>. 2021;18(4). doi:<a href=\"https://doi.org/10.1088/1478-3975/abd0db\">10.1088/1478-3975/abd0db</a>","mla":"Lenne, Pierre François, et al. “Roadmap for the Multiscale Coupling of Biochemical and Mechanical Signals during Development.” <i>Physical Biology</i>, vol. 18, no. 4, 041501, IOP Publishing, 2021, doi:<a href=\"https://doi.org/10.1088/1478-3975/abd0db\">10.1088/1478-3975/abd0db</a>.","ista":"Lenne PF, Munro E, Heemskerk I, Warmflash A, Bocanegra L, Kishi K, Kicheva A, Long Y, Fruleux A, Boudaoud A, Saunders TE, Caldarelli P, Michaut A, Gros J, Maroudas-Sacks Y, Keren K, Hannezo EB, Gartner ZJ, Stormo B, Gladfelter A, Rodrigues A, Shyer A, Minc N, Maître JL, Di Talia S, Khamaisi B, Sprinzak D, Tlili S. 2021. Roadmap for the multiscale coupling of biochemical and mechanical signals during development. Physical biology. 18(4), 041501.","ieee":"P. F. Lenne <i>et al.</i>, “Roadmap for the multiscale coupling of biochemical and mechanical signals during development,” <i>Physical biology</i>, vol. 18, no. 4. IOP Publishing, 2021.","chicago":"Lenne, Pierre François, Edwin Munro, Idse Heemskerk, Aryeh Warmflash, Laura Bocanegra, Kasumi Kishi, Anna Kicheva, et al. “Roadmap for the Multiscale Coupling of Biochemical and Mechanical Signals during Development.” <i>Physical Biology</i>. IOP Publishing, 2021. <a href=\"https://doi.org/10.1088/1478-3975/abd0db\">https://doi.org/10.1088/1478-3975/abd0db</a>.","short":"P.F. Lenne, E. Munro, I. Heemskerk, A. Warmflash, L. Bocanegra, K. Kishi, A. Kicheva, Y. Long, A. Fruleux, A. Boudaoud, T.E. Saunders, P. Caldarelli, A. Michaut, J. Gros, Y. Maroudas-Sacks, K. Keren, E.B. Hannezo, Z.J. Gartner, B. Stormo, A. Gladfelter, A. Rodrigues, A. Shyer, N. Minc, J.L. Maître, S. Di Talia, B. Khamaisi, D. Sprinzak, S. Tlili, Physical Biology 18 (2021).","apa":"Lenne, P. F., Munro, E., Heemskerk, I., Warmflash, A., Bocanegra, L., Kishi, K., … Tlili, S. (2021). Roadmap for the multiscale coupling of biochemical and mechanical signals during development. <i>Physical Biology</i>. IOP Publishing. <a href=\"https://doi.org/10.1088/1478-3975/abd0db\">https://doi.org/10.1088/1478-3975/abd0db</a>"},"ec_funded":1,"quality_controlled":"1"},{"has_accepted_license":"1","pmid":1,"year":"2021","publication_identifier":{"issn":["17597684"],"eissn":["17597692"]},"language":[{"iso":"eng"}],"related_material":{"record":[{"relation":"dissertation_contains","status":"public","id":"14323"}]},"acknowledgement":"Austrian Academy of Sciences, Grant/Award Number: DOC fellowship for Katarzyna Kuzmicz-Kowalska; Austrian Science Fund, Grant/Award Number: F78 (Stem Cell Modulation); H2020 European Research Council, Grant/Award Number: 680037","quality_controlled":"1","ec_funded":1,"citation":{"ama":"Kuzmicz-Kowalska K, Kicheva A. Regulation of size and scale in vertebrate spinal cord development. <i>Wiley Interdisciplinary Reviews: Developmental Biology</i>. 2021. doi:<a href=\"https://doi.org/10.1002/wdev.383\">10.1002/wdev.383</a>","short":"K. Kuzmicz-Kowalska, A. Kicheva, Wiley Interdisciplinary Reviews: Developmental Biology (2021).","chicago":"Kuzmicz-Kowalska, Katarzyna, and Anna Kicheva. “Regulation of Size and Scale in Vertebrate Spinal Cord Development.” <i>Wiley Interdisciplinary Reviews: Developmental Biology</i>. Wiley, 2021. <a href=\"https://doi.org/10.1002/wdev.383\">https://doi.org/10.1002/wdev.383</a>.","apa":"Kuzmicz-Kowalska, K., &#38; Kicheva, A. (2021). Regulation of size and scale in vertebrate spinal cord development. <i>Wiley Interdisciplinary Reviews: Developmental Biology</i>. Wiley. <a href=\"https://doi.org/10.1002/wdev.383\">https://doi.org/10.1002/wdev.383</a>","mla":"Kuzmicz-Kowalska, Katarzyna, and Anna Kicheva. “Regulation of Size and Scale in Vertebrate Spinal Cord Development.” <i>Wiley Interdisciplinary Reviews: Developmental Biology</i>, e383, Wiley, 2021, doi:<a href=\"https://doi.org/10.1002/wdev.383\">10.1002/wdev.383</a>.","ista":"Kuzmicz-Kowalska K, Kicheva A. 2021. Regulation of size and scale in vertebrate spinal cord development. Wiley Interdisciplinary Reviews: Developmental Biology., e383.","ieee":"K. Kuzmicz-Kowalska and A. Kicheva, “Regulation of size and scale in vertebrate spinal cord development,” <i>Wiley Interdisciplinary Reviews: Developmental Biology</i>. Wiley, 2021."},"doi":"10.1002/wdev.383","abstract":[{"lang":"eng","text":"All vertebrates have a spinal cord with dimensions and shape specific to their species. Yet how species‐specific organ size and shape are achieved is a fundamental unresolved question in biology. The formation and sculpting of organs begins during embryonic development. As it develops, the spinal cord extends in anterior–posterior direction in synchrony with the overall growth of the body. The dorsoventral (DV) and apicobasal lengths of the spinal cord neuroepithelium also change, while at the same time a characteristic pattern of neural progenitor subtypes along the DV axis is established and elaborated. At the basis of these changes in tissue size and shape are biophysical determinants, such as the change in cell number, cell size and shape, and anisotropic tissue growth. These processes are controlled by global tissue‐scale regulators, such as morphogen signaling gradients as well as mechanical forces. Current challenges in the field are to uncover how these tissue‐scale regulatory mechanisms are translated to the cellular and molecular level, and how regulation of distinct cellular processes gives rise to an overall defined size. Addressing these questions will help not only to achieve a better understanding of how size is controlled, but also of how tissue size is coordinated with the specification of pattern."}],"oa":1,"ddc":["570"],"file":[{"date_created":"2020-11-24T13:11:39Z","access_level":"open_access","file_id":"8800","relation":"main_file","file_name":"2020_WIREs_DevBio_KuzmiczKowalska.pdf","success":1,"content_type":"application/pdf","creator":"dernst","file_size":2527276,"checksum":"f0a7745d48afa09ea7025e876a0145a8","date_updated":"2020-11-24T13:11:39Z"}],"isi":1,"external_id":{"pmid":["32391980"],"isi":["000531419400001"]},"title":"Regulation of size and scale in vertebrate spinal cord development","tmp":{"image":"/images/cc_by.png","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"status":"public","article_number":"e383","day":"15","author":[{"first_name":"Katarzyna","id":"4CED352A-F248-11E8-B48F-1D18A9856A87","last_name":"Kuzmicz-Kowalska","full_name":"Kuzmicz-Kowalska, Katarzyna"},{"last_name":"Kicheva","id":"3959A2A0-F248-11E8-B48F-1D18A9856A87","first_name":"Anna","orcid":"0000-0003-4509-4998","full_name":"Kicheva, Anna"}],"department":[{"_id":"AnKi"}],"date_created":"2020-05-24T22:01:00Z","oa_version":"Published Version","project":[{"_id":"B6FC0238-B512-11E9-945C-1524E6697425","name":"Coordination of Patterning And Growth In the Spinal Cord","call_identifier":"H2020","grant_number":"680037"},{"name":"The role of morphogens in the regulation of neural tube growth","_id":"267AF0E4-B435-11E9-9278-68D0E5697425"},{"grant_number":"F07802","_id":"059DF620-7A3F-11EA-A408-12923DDC885E","name":"Morphogen control of growth and pattern in the spinal cord"}],"publication":"Wiley Interdisciplinary Reviews: Developmental Biology","file_date_updated":"2020-11-24T13:11:39Z","article_processing_charge":"Yes (via OA deal)","_id":"7883","type":"journal_article","publication_status":"published","user_id":"3E5EF7F0-F248-11E8-B48F-1D18A9856A87","date_updated":"2024-03-07T15:03:00Z","publisher":"Wiley","article_type":"original","date_published":"2021-04-15T00:00:00Z","month":"04","scopus_import":"1"},{"date_updated":"2023-09-06T11:26:36Z","publisher":"The Company of Biologists","publication_status":"published","user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1","article_type":"original","date_published":"2019-12-04T00:00:00Z","month":"12","scopus_import":"1","status":"public","article_number":"dev176297","volume":146,"tmp":{"image":"/images/cc_by.png","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"title":"Neuronal differentiation influences progenitor arrangement in the vertebrate neuroepithelium","day":"04","department":[{"_id":"AnKi"}],"author":[{"first_name":"Pilar","last_name":"Guerrero","full_name":"Guerrero, Pilar"},{"full_name":"Perez-Carrasco, Ruben","last_name":"Perez-Carrasco","first_name":"Ruben"},{"id":"343DA0DC-F248-11E8-B48F-1D18A9856A87","first_name":"Marcin P","last_name":"Zagórski","orcid":"0000-0001-7896-7762","full_name":"Zagórski, Marcin P"},{"full_name":"Page, David","first_name":"David","last_name":"Page"},{"orcid":"0000-0003-4509-4998","full_name":"Kicheva, Anna","first_name":"Anna","id":"3959A2A0-F248-11E8-B48F-1D18A9856A87","last_name":"Kicheva"},{"full_name":"Briscoe, James","first_name":"James","last_name":"Briscoe"},{"first_name":"Karen M.","last_name":"Page","full_name":"Page, Karen M."}],"file_date_updated":"2020-07-14T12:47:50Z","publication":"Development","issue":"23","_id":"7165","article_processing_charge":"No","type":"journal_article","date_created":"2019-12-10T14:39:50Z","oa_version":"Published Version","project":[{"name":"Coordination of Patterning And Growth In the Spinal Cord","_id":"B6FC0238-B512-11E9-945C-1524E6697425","call_identifier":"H2020","grant_number":"680037"}],"file":[{"content_type":"application/pdf","file_name":"2019_Development_Guerrero.pdf","relation":"main_file","file_id":"7177","access_level":"open_access","date_created":"2019-12-13T07:34:06Z","date_updated":"2020-07-14T12:47:50Z","file_size":7797881,"checksum":"b6533c37dc8fbd803ffeca216e0a8b8a","creator":"dernst"}],"abstract":[{"text":"Cell division, movement and differentiation contribute to pattern formation in developing tissues. This is the case in the vertebrate neural tube, in which neurons differentiate in a characteristic pattern from a highly dynamic proliferating pseudostratified epithelium. To investigate how progenitor proliferation and differentiation affect cell arrangement and growth of the neural tube, we used experimental measurements to develop a mechanical model of the apical surface of the neuroepithelium that incorporates the effect of interkinetic nuclear movement and spatially varying rates of neuronal differentiation. Simulations predict that tissue growth and the shape of lineage-related clones of cells differ with the rate of differentiation. Growth is isotropic in regions of high differentiation, but dorsoventrally biased in regions of low differentiation. This is consistent with experimental observations. The absence of directional signalling in the simulations indicates that global mechanical constraints are sufficient to explain the observed differences in anisotropy. This provides insight into how the tissue growth rate affects cell dynamics and growth anisotropy and opens up possibilities to study the coupling between mechanics, pattern formation and growth in the neural tube.","lang":"eng"}],"ddc":["570"],"oa":1,"external_id":{"pmid":["31784457"],"isi":["000507575700004"]},"isi":1,"intvolume":"       146","pmid":1,"has_accepted_license":"1","publication_identifier":{"eissn":["1477-9129"],"issn":["0950-1991"]},"language":[{"iso":"eng"}],"year":"2019","quality_controlled":"1","ec_funded":1,"doi":"10.1242/dev.176297","citation":{"ista":"Guerrero P, Perez-Carrasco R, Zagórski MP, Page D, Kicheva A, Briscoe J, Page KM. 2019. Neuronal differentiation influences progenitor arrangement in the vertebrate neuroepithelium. Development. 146(23), dev176297.","ieee":"P. Guerrero <i>et al.</i>, “Neuronal differentiation influences progenitor arrangement in the vertebrate neuroepithelium,” <i>Development</i>, vol. 146, no. 23. The Company of Biologists, 2019.","mla":"Guerrero, Pilar, et al. “Neuronal Differentiation Influences Progenitor Arrangement in the Vertebrate Neuroepithelium.” <i>Development</i>, vol. 146, no. 23, dev176297, The Company of Biologists, 2019, doi:<a href=\"https://doi.org/10.1242/dev.176297\">10.1242/dev.176297</a>.","apa":"Guerrero, P., Perez-Carrasco, R., Zagórski, M. P., Page, D., Kicheva, A., Briscoe, J., &#38; Page, K. M. (2019). Neuronal differentiation influences progenitor arrangement in the vertebrate neuroepithelium. <i>Development</i>. The Company of Biologists. <a href=\"https://doi.org/10.1242/dev.176297\">https://doi.org/10.1242/dev.176297</a>","chicago":"Guerrero, Pilar, Ruben Perez-Carrasco, Marcin P Zagórski, David Page, Anna Kicheva, James Briscoe, and Karen M. Page. “Neuronal Differentiation Influences Progenitor Arrangement in the Vertebrate Neuroepithelium.” <i>Development</i>. The Company of Biologists, 2019. <a href=\"https://doi.org/10.1242/dev.176297\">https://doi.org/10.1242/dev.176297</a>.","short":"P. Guerrero, R. Perez-Carrasco, M.P. Zagórski, D. Page, A. Kicheva, J. Briscoe, K.M. Page, Development 146 (2019).","ama":"Guerrero P, Perez-Carrasco R, Zagórski MP, et al. Neuronal differentiation influences progenitor arrangement in the vertebrate neuroepithelium. <i>Development</i>. 2019;146(23). doi:<a href=\"https://doi.org/10.1242/dev.176297\">10.1242/dev.176297</a>"}},{"date_published":"2018-06-13T00:00:00Z","month":"06","date_updated":"2023-09-18T09:29:07Z","publist_id":"7759","publisher":"eLife Sciences Publications","publication_status":"published","user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1","scopus_import":"1","day":"13","status":"public","article_number":"e34465","tmp":{"image":"/images/cc_by.png","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"volume":7,"title":"Signals from the brain and olfactory epithelium control shaping of the mammalian nasal capsule cartilage","publication":"eLife","file_date_updated":"2020-07-14T12:45:07Z","article_processing_charge":"No","_id":"162","type":"journal_article","oa_version":"Published Version","date_created":"2018-12-11T11:44:57Z","project":[{"grant_number":"680037","call_identifier":"H2020","name":"Coordination of Patterning And Growth In the Spinal Cord","_id":"B6FC0238-B512-11E9-945C-1524E6697425"}],"department":[{"_id":"AnKi"}],"author":[{"last_name":"Kaucka","first_name":"Marketa","full_name":"Kaucka, Marketa"},{"first_name":"Julian","last_name":"Petersen","full_name":"Petersen, Julian"},{"first_name":"Marketa","last_name":"Tesarova","full_name":"Tesarova, Marketa"},{"full_name":"Szarowska, Bara","first_name":"Bara","last_name":"Szarowska"},{"full_name":"Kastriti, Maria","last_name":"Kastriti","first_name":"Maria"},{"full_name":"Xie, Meng","first_name":"Meng","last_name":"Xie"},{"orcid":"0000-0003-4509-4998","full_name":"Kicheva, Anna","last_name":"Kicheva","first_name":"Anna","id":"3959A2A0-F248-11E8-B48F-1D18A9856A87"},{"last_name":"Annusver","first_name":"Karl","full_name":"Annusver, Karl"},{"first_name":"Maria","last_name":"Kasper","full_name":"Kasper, Maria"},{"full_name":"Symmons, Orsolya","last_name":"Symmons","first_name":"Orsolya"},{"full_name":"Pan, Leslie","last_name":"Pan","first_name":"Leslie"},{"first_name":"Francois","last_name":"Spitz","full_name":"Spitz, Francois"},{"last_name":"Kaiser","first_name":"Jozef","full_name":"Kaiser, Jozef"},{"last_name":"Hovorakova","first_name":"Maria","full_name":"Hovorakova, Maria"},{"first_name":"Tomas","last_name":"Zikmund","full_name":"Zikmund, Tomas"},{"first_name":"Kazunori","last_name":"Sunadome","full_name":"Sunadome, Kazunori"},{"full_name":"Matise, Michael P","last_name":"Matise","first_name":"Michael P"},{"full_name":"Wang, Hui","last_name":"Wang","first_name":"Hui"},{"full_name":"Marklund, Ulrika","last_name":"Marklund","first_name":"Ulrika"},{"full_name":"Abdo, Hind","first_name":"Hind","last_name":"Abdo"},{"full_name":"Ernfors, Patrik","first_name":"Patrik","last_name":"Ernfors"},{"last_name":"Maire","first_name":"Pascal","full_name":"Maire, Pascal"},{"full_name":"Wurmser, Maud","last_name":"Wurmser","first_name":"Maud"},{"last_name":"Chagin","first_name":"Andrei S","full_name":"Chagin, Andrei S"},{"full_name":"Fried, Kaj","last_name":"Fried","first_name":"Kaj"},{"last_name":"Adameyko","first_name":"Igor","full_name":"Adameyko, Igor"}],"file":[{"date_updated":"2020-07-14T12:45:07Z","creator":"dernst","checksum":"da2378cdcf6b5461dcde194e4d608343","file_size":9816484,"relation":"main_file","file_name":"2018_eLife_Kaucka.pdf","content_type":"application/pdf","date_created":"2018-12-17T16:41:58Z","access_level":"open_access","file_id":"5727"}],"abstract":[{"text":"Facial shape is the basis for facial recognition and categorization. Facial features reflect the underlying geometry of the skeletal structures. Here, we reveal that cartilaginous nasal capsule (corresponding to upper jaw and face) is shaped by signals generated by neural structures: brain and olfactory epithelium. Brain-derived Sonic Hedgehog (SHH) enables the induction of nasal septum and posterior nasal capsule, whereas the formation of a capsule roof is controlled by signals from the olfactory epithelium. Unexpectedly, the cartilage of the nasal capsule turned out to be important for shaping membranous facial bones during development. This suggests that conserved neurosensory structures could benefit from protection and have evolved signals inducing cranial cartilages encasing them. Experiments with mutant mice revealed that the genomic regulatory regions controlling production of SHH in the nervous system contribute to facial cartilage morphogenesis, which might be a mechanism responsible for the adaptive evolution of animal faces and snouts.","lang":"eng"}],"ddc":["571"],"oa":1,"external_id":{"isi":["000436227500001"]},"isi":1,"language":[{"iso":"eng"}],"year":"2018","intvolume":"         7","has_accepted_license":"1","quality_controlled":"1","ec_funded":1,"doi":"10.7554/eLife.34465","citation":{"ista":"Kaucka M, Petersen J, Tesarova M, Szarowska B, Kastriti M, Xie M, Kicheva A, Annusver K, Kasper M, Symmons O, Pan L, Spitz F, Kaiser J, Hovorakova M, Zikmund T, Sunadome K, Matise MP, Wang H, Marklund U, Abdo H, Ernfors P, Maire P, Wurmser M, Chagin AS, Fried K, Adameyko I. 2018. Signals from the brain and olfactory epithelium control shaping of the mammalian nasal capsule cartilage. eLife. 7, e34465.","ieee":"M. Kaucka <i>et al.</i>, “Signals from the brain and olfactory epithelium control shaping of the mammalian nasal capsule cartilage,” <i>eLife</i>, vol. 7. eLife Sciences Publications, 2018.","mla":"Kaucka, Marketa, et al. “Signals from the Brain and Olfactory Epithelium Control Shaping of the Mammalian Nasal Capsule Cartilage.” <i>ELife</i>, vol. 7, e34465, eLife Sciences Publications, 2018, doi:<a href=\"https://doi.org/10.7554/eLife.34465\">10.7554/eLife.34465</a>.","apa":"Kaucka, M., Petersen, J., Tesarova, M., Szarowska, B., Kastriti, M., Xie, M., … Adameyko, I. (2018). Signals from the brain and olfactory epithelium control shaping of the mammalian nasal capsule cartilage. <i>ELife</i>. eLife Sciences Publications. <a href=\"https://doi.org/10.7554/eLife.34465\">https://doi.org/10.7554/eLife.34465</a>","short":"M. Kaucka, J. Petersen, M. Tesarova, B. Szarowska, M. Kastriti, M. Xie, A. Kicheva, K. Annusver, M. Kasper, O. Symmons, L. Pan, F. Spitz, J. Kaiser, M. Hovorakova, T. Zikmund, K. Sunadome, M.P. Matise, H. Wang, U. Marklund, H. Abdo, P. Ernfors, P. Maire, M. Wurmser, A.S. Chagin, K. Fried, I. Adameyko, ELife 7 (2018).","chicago":"Kaucka, Marketa, Julian Petersen, Marketa Tesarova, Bara Szarowska, Maria Kastriti, Meng Xie, Anna Kicheva, et al. “Signals from the Brain and Olfactory Epithelium Control Shaping of the Mammalian Nasal Capsule Cartilage.” <i>ELife</i>. eLife Sciences Publications, 2018. <a href=\"https://doi.org/10.7554/eLife.34465\">https://doi.org/10.7554/eLife.34465</a>.","ama":"Kaucka M, Petersen J, Tesarova M, et al. Signals from the brain and olfactory epithelium control shaping of the mammalian nasal capsule cartilage. <i>eLife</i>. 2018;7. doi:<a href=\"https://doi.org/10.7554/eLife.34465\">10.7554/eLife.34465</a>"},"related_material":{"record":[{"relation":"research_data","id":"9838","status":"public"}]}},{"author":[{"full_name":"Kaucka, Marketa","first_name":"Marketa","last_name":"Kaucka"},{"last_name":"Petersen","first_name":"Julian","full_name":"Petersen, Julian"},{"full_name":"Tesarova, Marketa","last_name":"Tesarova","first_name":"Marketa"},{"first_name":"Bara","last_name":"Szarowska","full_name":"Szarowska, Bara"},{"full_name":"Kastriti, Maria Eleni","last_name":"Kastriti","first_name":"Maria Eleni"},{"full_name":"Xie, Meng","first_name":"Meng","last_name":"Xie"},{"id":"3959A2A0-F248-11E8-B48F-1D18A9856A87","first_name":"Anna","last_name":"Kicheva","full_name":"Kicheva, Anna","orcid":"0000-0003-4509-4998"},{"full_name":"Annusver, Karl","first_name":"Karl","last_name":"Annusver"},{"first_name":"Maria","last_name":"Kasper","full_name":"Kasper, Maria"},{"last_name":"Symmons","first_name":"Orsolya","full_name":"Symmons, Orsolya"},{"first_name":"Leslie","last_name":"Pan","full_name":"Pan, Leslie"},{"full_name":"Spitz, Francois","first_name":"Francois","last_name":"Spitz"},{"first_name":"Jozef","last_name":"Kaiser","full_name":"Kaiser, Jozef"},{"full_name":"Hovorakova, Maria","last_name":"Hovorakova","first_name":"Maria"},{"first_name":"Tomas","last_name":"Zikmund","full_name":"Zikmund, Tomas"},{"last_name":"Sunadome","first_name":"Kazunori","full_name":"Sunadome, Kazunori"},{"full_name":"Matise, Michael P","last_name":"Matise","first_name":"Michael P"},{"full_name":"Wang, Hui","first_name":"Hui","last_name":"Wang"},{"full_name":"Marklund, Ulrika","first_name":"Ulrika","last_name":"Marklund"},{"full_name":"Abdo, Hind","last_name":"Abdo","first_name":"Hind"},{"last_name":"Ernfors","first_name":"Patrik","full_name":"Ernfors, Patrik"},{"full_name":"Maire, Pascal","first_name":"Pascal","last_name":"Maire"},{"full_name":"Wurmser, Maud","last_name":"Wurmser","first_name":"Maud"},{"first_name":"Andrei S","last_name":"Chagin","full_name":"Chagin, Andrei S"},{"first_name":"Kaj","last_name":"Fried","full_name":"Fried, Kaj"},{"full_name":"Adameyko, Igor","first_name":"Igor","last_name":"Adameyko"}],"related_material":{"record":[{"id":"162","status":"public","relation":"used_in_publication"}]},"department":[{"_id":"AnKi"}],"date_created":"2021-08-09T12:54:35Z","oa_version":"Published Version","doi":"10.5061/dryad.f1s76f2","citation":{"chicago":"Kaucka, Marketa, Julian Petersen, Marketa Tesarova, Bara Szarowska, Maria Eleni Kastriti, Meng Xie, Anna Kicheva, et al. “Data from: Signals from the Brain and Olfactory Epithelium Control Shaping of the Mammalian Nasal Capsule Cartilage.” Dryad, 2018. <a href=\"https://doi.org/10.5061/dryad.f1s76f2\">https://doi.org/10.5061/dryad.f1s76f2</a>.","short":"M. Kaucka, J. Petersen, M. Tesarova, B. Szarowska, M.E. Kastriti, M. Xie, A. Kicheva, K. Annusver, M. Kasper, O. Symmons, L. Pan, F. Spitz, J. Kaiser, M. Hovorakova, T. Zikmund, K. Sunadome, M.P. Matise, H. Wang, U. Marklund, H. Abdo, P. Ernfors, P. Maire, M. Wurmser, A.S. Chagin, K. Fried, I. Adameyko, (2018).","apa":"Kaucka, M., Petersen, J., Tesarova, M., Szarowska, B., Kastriti, M. E., Xie, M., … Adameyko, I. (2018). Data from: Signals from the brain and olfactory epithelium control shaping of the mammalian nasal capsule cartilage. Dryad. <a href=\"https://doi.org/10.5061/dryad.f1s76f2\">https://doi.org/10.5061/dryad.f1s76f2</a>","mla":"Kaucka, Marketa, et al. <i>Data from: Signals from the Brain and Olfactory Epithelium Control Shaping of the Mammalian Nasal Capsule Cartilage</i>. Dryad, 2018, doi:<a href=\"https://doi.org/10.5061/dryad.f1s76f2\">10.5061/dryad.f1s76f2</a>.","ista":"Kaucka M, Petersen J, Tesarova M, Szarowska B, Kastriti ME, Xie M, Kicheva A, Annusver K, Kasper M, Symmons O, Pan L, Spitz F, Kaiser J, Hovorakova M, Zikmund T, Sunadome K, Matise MP, Wang H, Marklund U, Abdo H, Ernfors P, Maire P, Wurmser M, Chagin AS, Fried K, Adameyko I. 2018. Data from: Signals from the brain and olfactory epithelium control shaping of the mammalian nasal capsule cartilage, Dryad, <a href=\"https://doi.org/10.5061/dryad.f1s76f2\">10.5061/dryad.f1s76f2</a>.","ieee":"M. Kaucka <i>et al.</i>, “Data from: Signals from the brain and olfactory epithelium control shaping of the mammalian nasal capsule cartilage.” Dryad, 2018.","ama":"Kaucka M, Petersen J, Tesarova M, et al. Data from: Signals from the brain and olfactory epithelium control shaping of the mammalian nasal capsule cartilage. 2018. doi:<a href=\"https://doi.org/10.5061/dryad.f1s76f2\">10.5061/dryad.f1s76f2</a>"},"article_processing_charge":"No","_id":"9838","type":"research_data_reference","title":"Data from: Signals from the brain and olfactory epithelium control shaping of the mammalian nasal capsule cartilage","status":"public","year":"2018","day":"14","main_file_link":[{"url":"https://doi.org/10.5061/dryad.f1s76f2","open_access":"1"}],"user_id":"6785fbc1-c503-11eb-8a32-93094b40e1cf","date_updated":"2023-09-18T09:29:07Z","publisher":"Dryad","abstract":[{"text":"Facial shape is the basis for facial recognition and categorization. Facial features reflect the underlying geometry of the skeletal structures. Here we reveal that cartilaginous nasal capsule (corresponding to upper jaw and face) is shaped by signals generated by neural structures: brain and olfactory epithelium. Brain-derived Sonic Hedgehog (SHH) enables the induction of nasal septum and posterior nasal capsule, whereas the formation of a capsule roof is controlled by signals from the olfactory epithelium. Unexpectedly, the cartilage of the nasal capsule turned out to be important for shaping membranous facial bones during development. This suggests that conserved neurosensory structures could benefit from protection and have evolved signals inducing cranial cartilages encasing them. Experiments with mutant mice revealed that the genomic regulatory regions controlling production of SHH in the nervous system contribute to facial cartilage morphogenesis, which might be a mechanism responsible for the adaptive evolution of animal faces and snouts.","lang":"eng"}],"oa":1,"date_published":"2018-06-14T00:00:00Z","month":"06"},{"quality_controlled":"1","ec_funded":1,"doi":"10.1007/978-1-4939-8772-6_4","citation":{"ama":"Zagórski MP, Kicheva A. Measuring dorsoventral pattern and morphogen signaling profiles in the growing neural tube. In: <i>Morphogen Gradients </i>. Vol 1863. MIMB. Springer Nature; 2018:47-63. doi:<a href=\"https://doi.org/10.1007/978-1-4939-8772-6_4\">10.1007/978-1-4939-8772-6_4</a>","ista":"Zagórski MP, Kicheva A. 2018.Measuring dorsoventral pattern and morphogen signaling profiles in the growing neural tube. In: Morphogen Gradients . Methods in Molecular Biology, vol. 1863, 47–63.","ieee":"M. P. Zagórski and A. Kicheva, “Measuring dorsoventral pattern and morphogen signaling profiles in the growing neural tube,” in <i>Morphogen Gradients </i>, vol. 1863, Springer Nature, 2018, pp. 47–63.","mla":"Zagórski, Marcin P., and Anna Kicheva. “Measuring Dorsoventral Pattern and Morphogen Signaling Profiles in the Growing Neural Tube.” <i>Morphogen Gradients </i>, vol. 1863, Springer Nature, 2018, pp. 47–63, doi:<a href=\"https://doi.org/10.1007/978-1-4939-8772-6_4\">10.1007/978-1-4939-8772-6_4</a>.","apa":"Zagórski, M. P., &#38; Kicheva, A. (2018). Measuring dorsoventral pattern and morphogen signaling profiles in the growing neural tube. In <i>Morphogen Gradients </i> (Vol. 1863, pp. 47–63). Springer Nature. <a href=\"https://doi.org/10.1007/978-1-4939-8772-6_4\">https://doi.org/10.1007/978-1-4939-8772-6_4</a>","chicago":"Zagórski, Marcin P, and Anna Kicheva. “Measuring Dorsoventral Pattern and Morphogen Signaling Profiles in the Growing Neural Tube.” In <i>Morphogen Gradients </i>, 1863:47–63. MIMB. Springer Nature, 2018. <a href=\"https://doi.org/10.1007/978-1-4939-8772-6_4\">https://doi.org/10.1007/978-1-4939-8772-6_4</a>.","short":"M.P. Zagórski, A. Kicheva, in:, Morphogen Gradients , Springer Nature, 2018, pp. 47–63."},"has_accepted_license":"1","intvolume":"      1863","year":"2018","publication_identifier":{"isbn":["978-1-4939-8771-9"],"issn":["1064-3745"]},"language":[{"iso":"eng"}],"page":"47 - 63","alternative_title":["Methods in Molecular Biology"],"abstract":[{"text":"Developmental processes are inherently dynamic and understanding them requires quantitative measurements of gene and protein expression levels in space and time. While live imaging is a powerful approach for obtaining such data, it is still a challenge to apply it over long periods of time to large tissues, such as the embryonic spinal cord in mouse and chick. Nevertheless, dynamics of gene expression and signaling activity patterns in this organ can be studied by collecting tissue sections at different developmental stages. In combination with immunohistochemistry, this allows for measuring the levels of multiple developmental regulators in a quantitative manner with high spatiotemporal resolution. The mean protein expression levels over time, as well as embryo-to-embryo variability can be analyzed. A key aspect of the approach is the ability to compare protein levels across different samples. This requires a number of considerations in sample preparation, imaging and data analysis. Here we present a protocol for obtaining time course data of dorsoventral expression patterns from mouse and chick neural tube in the first 3 days of neural tube development. The described workflow starts from embryo dissection and ends with a processed dataset. Software scripts for data analysis are included. The protocol is adaptable and instructions that allow the user to modify different steps are provided. Thus, the procedure can be altered for analysis of time-lapse images and applied to systems other than the neural tube.","lang":"eng"}],"ddc":["570"],"oa":1,"file":[{"file_size":4906815,"checksum":"2a97d0649fdcfcf1bdca7c8ad1dce71b","creator":"dernst","date_updated":"2020-10-13T14:20:37Z","file_id":"8656","date_created":"2020-10-13T14:20:37Z","access_level":"open_access","content_type":"application/pdf","success":1,"relation":"main_file","file_name":"2018_MIMB_Zagorski.pdf"}],"author":[{"orcid":"0000-0001-7896-7762","full_name":"Zagórski, Marcin P","id":"343DA0DC-F248-11E8-B48F-1D18A9856A87","first_name":"Marcin P","last_name":"Zagórski"},{"full_name":"Kicheva, Anna","orcid":"0000-0003-4509-4998","first_name":"Anna","id":"3959A2A0-F248-11E8-B48F-1D18A9856A87","last_name":"Kicheva"}],"department":[{"_id":"AnKi"}],"oa_version":"Submitted Version","date_created":"2018-12-11T11:44:17Z","project":[{"_id":"B6FC0238-B512-11E9-945C-1524E6697425","name":"Coordination of Patterning And Growth In the Spinal Cord","grant_number":"680037","call_identifier":"H2020"}],"file_date_updated":"2020-10-13T14:20:37Z","publication":"Morphogen Gradients ","_id":"37","type":"book_chapter","article_processing_charge":"No","title":"Measuring dorsoventral pattern and morphogen signaling profiles in the growing neural tube","volume":1863,"status":"public","day":"16","scopus_import":"1","series_title":"MIMB","publication_status":"published","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","publist_id":"8018","date_updated":"2021-01-12T07:49:03Z","publisher":"Springer Nature","month":"10","date_published":"2018-10-16T00:00:00Z"},{"author":[{"first_name":"Guntram","last_name":"Bauer","full_name":"Bauer, Guntram"},{"first_name":"Nikta","last_name":"Fakhri","full_name":"Fakhri, Nikta"},{"last_name":"Kicheva","first_name":"Anna","id":"3959A2A0-F248-11E8-B48F-1D18A9856A87","full_name":"Kicheva, Anna","orcid":"0000-0003-4509-4998"},{"first_name":"Jané","last_name":"Kondev","full_name":"Kondev, Jané"},{"first_name":"Karsten","last_name":"Kruse","full_name":"Kruse, Karsten"},{"first_name":"Hiroyuki","last_name":"Noji","full_name":"Noji, Hiroyuki"},{"full_name":"Riveline, Daniel","last_name":"Riveline","first_name":"Daniel"},{"last_name":"Saunders","first_name":"Timothy","full_name":"Saunders, Timothy"},{"full_name":"Thatta, Mukund","first_name":"Mukund","last_name":"Thatta"},{"full_name":"Wieschaus, Eric","first_name":"Eric","last_name":"Wieschaus"}],"department":[{"_id":"AnKi"}],"date_created":"2018-12-11T11:45:46Z","oa_version":"Published Version","publication":"Cell Systems","article_processing_charge":"No","_id":"314","issue":"4","type":"journal_article","volume":6,"title":"The science of living matter for tomorrow","status":"public","day":"25","scopus_import":"1","main_file_link":[{"open_access":"1","url":"https://doi.org/10.1016/j.cels.2018.04.003"}],"publication_status":"published","user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1","date_updated":"2023-09-19T10:11:25Z","publist_id":"7551","publisher":"Cell Press","article_type":"letter_note","date_published":"2018-04-25T00:00:00Z","month":"04","quality_controlled":"1","citation":{"ama":"Bauer G, Fakhri N, Kicheva A, et al. The science of living matter for tomorrow. <i>Cell Systems</i>. 2018;6(4):400-402. doi:<a href=\"https://doi.org/10.1016/j.cels.2018.04.003\">10.1016/j.cels.2018.04.003</a>","mla":"Bauer, Guntram, et al. “The Science of Living Matter for Tomorrow.” <i>Cell Systems</i>, vol. 6, no. 4, Cell Press, 2018, pp. 400–02, doi:<a href=\"https://doi.org/10.1016/j.cels.2018.04.003\">10.1016/j.cels.2018.04.003</a>.","ista":"Bauer G, Fakhri N, Kicheva A, Kondev J, Kruse K, Noji H, Riveline D, Saunders T, Thatta M, Wieschaus E. 2018. The science of living matter for tomorrow. Cell Systems. 6(4), 400–402.","ieee":"G. Bauer <i>et al.</i>, “The science of living matter for tomorrow,” <i>Cell Systems</i>, vol. 6, no. 4. Cell Press, pp. 400–402, 2018.","short":"G. Bauer, N. Fakhri, A. Kicheva, J. Kondev, K. Kruse, H. Noji, D. Riveline, T. Saunders, M. Thatta, E. Wieschaus, Cell Systems 6 (2018) 400–402.","chicago":"Bauer, Guntram, Nikta Fakhri, Anna Kicheva, Jané Kondev, Karsten Kruse, Hiroyuki Noji, Daniel Riveline, Timothy Saunders, Mukund Thatta, and Eric Wieschaus. “The Science of Living Matter for Tomorrow.” <i>Cell Systems</i>. Cell Press, 2018. <a href=\"https://doi.org/10.1016/j.cels.2018.04.003\">https://doi.org/10.1016/j.cels.2018.04.003</a>.","apa":"Bauer, G., Fakhri, N., Kicheva, A., Kondev, J., Kruse, K., Noji, H., … Wieschaus, E. (2018). The science of living matter for tomorrow. <i>Cell Systems</i>. Cell Press. <a href=\"https://doi.org/10.1016/j.cels.2018.04.003\">https://doi.org/10.1016/j.cels.2018.04.003</a>"},"doi":"10.1016/j.cels.2018.04.003","intvolume":"         6","pmid":1,"year":"2018","publication_identifier":{"eissn":["2405-4712"]},"language":[{"iso":"eng"}],"isi":1,"page":"400 - 402","external_id":{"pmid":["29698645"],"isi":["000432192100003"]},"abstract":[{"text":"The interface of physics and biology pro-vides a fruitful environment for generatingnew concepts and exciting ways forwardto understanding living matter. Examplesof successful studies include the estab-lishment and readout of morphogen gra-dients during development, signal pro-cessing in protein and genetic networks,the role of fluctuations in determining thefates of cells and tissues, and collectiveeffects in proteins and in tissues. It is nothard to envision that significant further ad-vances will translate to societal benefitsby initiating the development of new de-vices and strategies for curing disease.However, research at the interface posesvarious challenges, in particular for youngscientists, and current institutions arerarely designed to facilitate such scientificprograms. In this Letter, we propose aninternational initiative that addressesthese challenges through the establish-ment of a worldwide network of platformsfor cross-disciplinary training and incuba-tors for starting new collaborations.","lang":"eng"}],"oa":1},{"year":"2017","language":[{"iso":"eng"}],"publication_identifier":{"issn":["09501991"]},"has_accepted_license":"1","intvolume":"       144","quality_controlled":"1","ec_funded":1,"doi":"10.1242/dev.144915","citation":{"ama":"Kicheva A, Rivron N. Creating to understand – developmental biology meets engineering in Paris. <i>Development</i>. 2017;144(5):733-736. doi:<a href=\"https://doi.org/10.1242/dev.144915\">10.1242/dev.144915</a>","chicago":"Kicheva, Anna, and Nicolas Rivron. “Creating to Understand – Developmental Biology Meets Engineering in Paris.” <i>Development</i>. Company of Biologists, 2017. <a href=\"https://doi.org/10.1242/dev.144915\">https://doi.org/10.1242/dev.144915</a>.","short":"A. Kicheva, N. Rivron, Development 144 (2017) 733–736.","apa":"Kicheva, A., &#38; Rivron, N. (2017). Creating to understand – developmental biology meets engineering in Paris. <i>Development</i>. Company of Biologists. <a href=\"https://doi.org/10.1242/dev.144915\">https://doi.org/10.1242/dev.144915</a>","mla":"Kicheva, Anna, and Nicolas Rivron. “Creating to Understand – Developmental Biology Meets Engineering in Paris.” <i>Development</i>, vol. 144, no. 5, Company of Biologists, 2017, pp. 733–36, doi:<a href=\"https://doi.org/10.1242/dev.144915\">10.1242/dev.144915</a>.","ieee":"A. Kicheva and N. Rivron, “Creating to understand – developmental biology meets engineering in Paris,” <i>Development</i>, vol. 144, no. 5. Company of Biologists, pp. 733–736, 2017.","ista":"Kicheva A, Rivron N. 2017. Creating to understand – developmental biology meets engineering in Paris. Development. 144(5), 733–736."},"abstract":[{"lang":"eng","text":"In November 2016, developmental biologists, synthetic biologists and engineers gathered in Paris for a meeting called ‘Engineering the embryo’. The participants shared an interest in exploring how synthetic systems can reveal new principles of embryonic development, and how the in vitro manipulation and modeling of development using stem cells can be used to integrate ideas and expertise from physics, developmental biology and tissue engineering. As we review here, the conference pinpointed some of the challenges arising at the intersection of these fields, along with great enthusiasm for finding new approaches and collaborations."}],"ddc":["571"],"oa":1,"file":[{"creator":"system","checksum":"eef22a0f42a55b232cb2d1188a2322cb","file_size":228206,"date_updated":"2020-07-14T12:47:33Z","date_created":"2018-12-12T10:15:20Z","access_level":"open_access","file_id":"5139","file_name":"IST-2018-987-v1+1_2017_KichevaRivron__Creating_to.pdf","relation":"main_file","content_type":"application/pdf"}],"page":"733 - 736","day":"01","volume":144,"title":"Creating to understand – developmental biology meets engineering in Paris","status":"public","date_created":"2018-12-11T11:47:44Z","pubrep_id":"987","oa_version":"Submitted Version","project":[{"_id":"B6FC0238-B512-11E9-945C-1524E6697425","name":"Coordination of Patterning And Growth In the Spinal Cord","grant_number":"680037","call_identifier":"H2020"}],"publication":"Development","file_date_updated":"2020-07-14T12:47:33Z","_id":"654","issue":"5","type":"journal_article","author":[{"orcid":"0000-0003-4509-4998","full_name":"Kicheva, Anna","id":"3959A2A0-F248-11E8-B48F-1D18A9856A87","first_name":"Anna","last_name":"Kicheva"},{"full_name":"Rivron, Nicolas","first_name":"Nicolas","last_name":"Rivron"}],"department":[{"_id":"AnKi"}],"date_published":"2017-03-01T00:00:00Z","month":"03","publication_status":"published","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","publist_id":"7089","date_updated":"2021-01-12T08:07:54Z","publisher":"Company of Biologists","scopus_import":1},{"file":[{"creator":"dernst","checksum":"727043d2e4199fbef6b3704e6d1ac105","file_size":652313,"date_updated":"2020-07-14T12:47:42Z","access_level":"open_access","date_created":"2019-04-17T07:58:48Z","file_id":"6335","file_name":"2017_Briscoe_Kicheva_and_DArcy_accepted_version.pdf","relation":"main_file","content_type":"application/pdf"}],"oa":1,"ddc":["571"],"abstract":[{"text":"By applying methods and principles from the physical sciences to biological problems, D'Arcy Thompson's On Growth and Form demonstrated how mathematical reasoning reveals elegant, simple explanations for seemingly complex processes. This has had a profound influence on subsequent generations of developmental biologists. We discuss how this influence can be traced through twentieth century morphologists, embryologists and theoreticians to current research that explores the molecular and cellular mechanisms of tissue growth and patterning, including our own studies of the vertebrate neural tube.","lang":"eng"}],"external_id":{"pmid":["28366718"]},"page":"26 - 31","publication_identifier":{"issn":["09254773"]},"language":[{"iso":"eng"}],"year":"2017","pmid":1,"intvolume":"       145","has_accepted_license":"1","doi":"10.1016/j.mod.2017.03.005","citation":{"mla":"Briscoe, James, and Anna Kicheva. “The Physics of Development 100 Years after D’Arcy Thompson’s ‘on Growth and Form.’” <i>Mechanisms of Development</i>, vol. 145, Elsevier, 2017, pp. 26–31, doi:<a href=\"https://doi.org/10.1016/j.mod.2017.03.005\">10.1016/j.mod.2017.03.005</a>.","ista":"Briscoe J, Kicheva A. 2017. The physics of development 100 years after D’Arcy Thompson’s “on growth and form”. Mechanisms of Development. 145, 26–31.","ieee":"J. Briscoe and A. Kicheva, “The physics of development 100 years after D’Arcy Thompson’s ‘on growth and form,’” <i>Mechanisms of Development</i>, vol. 145. Elsevier, pp. 26–31, 2017.","short":"J. Briscoe, A. Kicheva, Mechanisms of Development 145 (2017) 26–31.","chicago":"Briscoe, James, and Anna Kicheva. “The Physics of Development 100 Years after D’Arcy Thompson’s ‘on Growth and Form.’” <i>Mechanisms of Development</i>. Elsevier, 2017. <a href=\"https://doi.org/10.1016/j.mod.2017.03.005\">https://doi.org/10.1016/j.mod.2017.03.005</a>.","apa":"Briscoe, J., &#38; Kicheva, A. (2017). The physics of development 100 years after D’Arcy Thompson’s “on growth and form.” <i>Mechanisms of Development</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.mod.2017.03.005\">https://doi.org/10.1016/j.mod.2017.03.005</a>","ama":"Briscoe J, Kicheva A. The physics of development 100 years after D’Arcy Thompson’s “on growth and form.” <i>Mechanisms of Development</i>. 2017;145:26-31. doi:<a href=\"https://doi.org/10.1016/j.mod.2017.03.005\">10.1016/j.mod.2017.03.005</a>"},"ec_funded":1,"quality_controlled":"1","month":"06","date_published":"2017-06-01T00:00:00Z","publisher":"Elsevier","date_updated":"2021-01-12T08:09:20Z","publist_id":"7025","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","publication_status":"published","scopus_import":1,"day":"01","status":"public","title":"The physics of development 100 years after D'Arcy Thompson's “on growth and form”","volume":145,"_id":"685","type":"journal_article","file_date_updated":"2020-07-14T12:47:42Z","publication":"Mechanisms of Development","project":[{"_id":"B6FC0238-B512-11E9-945C-1524E6697425","name":"Coordination of Patterning And Growth In the Spinal Cord","call_identifier":"H2020","grant_number":"680037"}],"oa_version":"Submitted Version","pubrep_id":"985","date_created":"2018-12-11T11:47:55Z","department":[{"_id":"AnKi"}],"author":[{"full_name":"Briscoe, James","first_name":"James","last_name":"Briscoe"},{"orcid":"0000-0003-4509-4998","full_name":"Kicheva, Anna","last_name":"Kicheva","id":"3959A2A0-F248-11E8-B48F-1D18A9856A87","first_name":"Anna"}]},{"external_id":{"isi":["000404351500036"],"pmid":["28663499"]},"isi":1,"page":"1379 - 1383","oa":1,"abstract":[{"lang":"eng","text":"Like many developing tissues, the vertebrate neural tube is patterned by antiparallel morphogen gradients. To understand how these inputs are interpreted, we measured morphogen signaling and target gene expression in mouse embryos and chick ex vivo assays. From these data, we derived and validated a characteristic decoding map that relates morphogen input to the positional identity of neural progenitors. Analysis of the observed responses indicates that the underlying interpretation strategy minimizes patterning errors in response to the joint input of noisy opposing gradients. We reverse-engineered a transcriptional network that provides a mechanistic basis for the observed cell fate decisions and accounts for the precision and dynamics of pattern formation. Together, our data link opposing gradient dynamics in a growing tissue to precise pattern formation."}],"citation":{"ama":"Zagórski MP, Tabata Y, Brandenberg N, et al. Decoding of position in the developing neural tube from antiparallel morphogen gradients. <i>Science</i>. 2017;356(6345):1379-1383. doi:<a href=\"https://doi.org/10.1126/science.aam5887\">10.1126/science.aam5887</a>","mla":"Zagórski, Marcin P., et al. “Decoding of Position in the Developing Neural Tube from Antiparallel Morphogen Gradients.” <i>Science</i>, vol. 356, no. 6345, American Association for the Advancement of Science, 2017, pp. 1379–83, doi:<a href=\"https://doi.org/10.1126/science.aam5887\">10.1126/science.aam5887</a>.","ista":"Zagórski MP, Tabata Y, Brandenberg N, Lutolf M, Tkačik G, Bollenbach T, Briscoe J, Kicheva A. 2017. Decoding of position in the developing neural tube from antiparallel morphogen gradients. Science. 356(6345), 1379–1383.","ieee":"M. P. Zagórski <i>et al.</i>, “Decoding of position in the developing neural tube from antiparallel morphogen gradients,” <i>Science</i>, vol. 356, no. 6345. American Association for the Advancement of Science, pp. 1379–1383, 2017.","chicago":"Zagórski, Marcin P, Yoji Tabata, Nathalie Brandenberg, Matthias Lutolf, Gašper Tkačik, Tobias Bollenbach, James Briscoe, and Anna Kicheva. “Decoding of Position in the Developing Neural Tube from Antiparallel Morphogen Gradients.” <i>Science</i>. American Association for the Advancement of Science, 2017. <a href=\"https://doi.org/10.1126/science.aam5887\">https://doi.org/10.1126/science.aam5887</a>.","short":"M.P. Zagórski, Y. Tabata, N. Brandenberg, M. Lutolf, G. Tkačik, T. Bollenbach, J. Briscoe, A. Kicheva, Science 356 (2017) 1379–1383.","apa":"Zagórski, M. P., Tabata, Y., Brandenberg, N., Lutolf, M., Tkačik, G., Bollenbach, T., … Kicheva, A. (2017). Decoding of position in the developing neural tube from antiparallel morphogen gradients. <i>Science</i>. American Association for the Advancement of Science. <a href=\"https://doi.org/10.1126/science.aam5887\">https://doi.org/10.1126/science.aam5887</a>"},"doi":"10.1126/science.aam5887","ec_funded":1,"quality_controlled":"1","pmid":1,"intvolume":"       356","publication_identifier":{"issn":["00368075"]},"language":[{"iso":"eng"}],"year":"2017","scopus_import":"1","main_file_link":[{"open_access":"1","url":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5568706/"}],"publisher":"American Association for the Advancement of Science","date_updated":"2023-09-26T15:38:05Z","publist_id":"6474","user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1","publication_status":"published","date_published":"2017-06-30T00:00:00Z","month":"06","department":[{"_id":"AnKi"},{"_id":"GaTk"}],"author":[{"last_name":"Zagórski","id":"343DA0DC-F248-11E8-B48F-1D18A9856A87","first_name":"Marcin P","orcid":"0000-0001-7896-7762","full_name":"Zagórski, Marcin P"},{"full_name":"Tabata, Yoji","first_name":"Yoji","last_name":"Tabata"},{"full_name":"Brandenberg, Nathalie","first_name":"Nathalie","last_name":"Brandenberg"},{"last_name":"Lutolf","first_name":"Matthias","full_name":"Lutolf, Matthias"},{"orcid":"0000-0002-6699-1455","full_name":"Tkacik, Gasper","first_name":"Gasper","id":"3D494DCA-F248-11E8-B48F-1D18A9856A87","last_name":"Tkacik"},{"last_name":"Bollenbach","first_name":"Tobias","full_name":"Bollenbach, Tobias"},{"full_name":"Briscoe, James","last_name":"Briscoe","first_name":"James"},{"last_name":"Kicheva","id":"3959A2A0-F248-11E8-B48F-1D18A9856A87","first_name":"Anna","full_name":"Kicheva, Anna","orcid":"0000-0003-4509-4998"}],"_id":"943","type":"journal_article","article_processing_charge":"No","issue":"6345","publication":"Science","project":[{"grant_number":"P28844-B27","call_identifier":"FWF","_id":"254E9036-B435-11E9-9278-68D0E5697425","name":"Biophysics of information processing in gene regulation"},{"grant_number":"680037","call_identifier":"H2020","_id":"B6FC0238-B512-11E9-945C-1524E6697425","name":"Coordination of Patterning And Growth In the Spinal Cord"},{"grant_number":"291734","call_identifier":"FP7","_id":"25681D80-B435-11E9-9278-68D0E5697425","name":"International IST Postdoc Fellowship Programme"},{"name":"Developing High-Throughput Bioassays for Human Cancers in Zebrafish","_id":"2524F500-B435-11E9-9278-68D0E5697425","grant_number":"201439","call_identifier":"FP7"}],"date_created":"2018-12-11T11:49:20Z","oa_version":"Submitted Version","status":"public","title":"Decoding of position in the developing neural tube from antiparallel morphogen gradients","volume":356,"day":"30"},{"date_published":"2015-04-02T00:00:00Z","month":"04","abstract":[{"lang":"eng","text":"In the vertebrate neural tube, the morphogen Sonic Hedgehog (Shh) establishes a characteristic pattern of gene expression. Here we quantify the Shh gradient in the developing mouse neural tube and show that while the amplitude of the gradient increases over time, the activity of the pathway transcriptional effectors, Gli proteins, initially increases but later decreases. Computational analysis of the pathway suggests three mechanisms that could contribute to this adaptation: transcriptional upregulation of the inhibitory receptor Ptch1, transcriptional downregulation of Gli and the differential stability of active and inactive Gli isoforms. Consistent with this, Gli2 protein expression is downregulated during neural tube patterning and adaptation continues when the pathway is stimulated downstream of Ptch1. Moreover, the Shh-induced upregulation of Gli2 transcription prevents Gli activity levels from adapting in a different cell type, NIH3T3 fibroblasts, despite the upregulation of Ptch1. Multiple mechanisms therefore contribute to the intracellular dynamics of Shh signalling, resulting in different signalling dynamics in different cell types."}],"publisher":"Nature Publishing Group","publist_id":"5399","date_updated":"2021-01-12T06:52:48Z","publication_status":"published","_id":"1728","type":"journal_article","extern":1,"publication":"Nature Communications","citation":{"ieee":"M. Cohen <i>et al.</i>, “Ptch1 and Gli regulate Shh signalling dynamics via multiple mechanisms,” <i>Nature Communications</i>, vol. 6. Nature Publishing Group, 2015.","ista":"Cohen M, Kicheva A, Ribeiro A, Blassberg R, Page K, Barnes C, Briscoe J. 2015. Ptch1 and Gli regulate Shh signalling dynamics via multiple mechanisms. Nature Communications. 6.","mla":"Cohen, Michael, et al. “Ptch1 and Gli Regulate Shh Signalling Dynamics via Multiple Mechanisms.” <i>Nature Communications</i>, vol. 6, Nature Publishing Group, 2015, doi:<a href=\"https://doi.org/10.1038/ncomms7709\">10.1038/ncomms7709</a>.","apa":"Cohen, M., Kicheva, A., Ribeiro, A., Blassberg, R., Page, K., Barnes, C., &#38; Briscoe, J. (2015). Ptch1 and Gli regulate Shh signalling dynamics via multiple mechanisms. <i>Nature Communications</i>. Nature Publishing Group. <a href=\"https://doi.org/10.1038/ncomms7709\">https://doi.org/10.1038/ncomms7709</a>","short":"M. Cohen, A. Kicheva, A. Ribeiro, R. Blassberg, K. Page, C. Barnes, J. Briscoe, Nature Communications 6 (2015).","chicago":"Cohen, Michael, Anna Kicheva, Ana Ribeiro, Robert Blassberg, Karen Page, Chris Barnes, and James Briscoe. “Ptch1 and Gli Regulate Shh Signalling Dynamics via Multiple Mechanisms.” <i>Nature Communications</i>. Nature Publishing Group, 2015. <a href=\"https://doi.org/10.1038/ncomms7709\">https://doi.org/10.1038/ncomms7709</a>.","ama":"Cohen M, Kicheva A, Ribeiro A, et al. Ptch1 and Gli regulate Shh signalling dynamics via multiple mechanisms. <i>Nature Communications</i>. 2015;6. doi:<a href=\"https://doi.org/10.1038/ncomms7709\">10.1038/ncomms7709</a>"},"doi":"10.1038/ncomms7709","quality_controlled":0,"date_created":"2018-12-11T11:53:42Z","acknowledgement":"C.P.B. gratefully acknowledges funding from the Wellcome Trust through a Research Career Development Fellowship (097319/Z/11/Z). This work was supported by the Medical Research Council (U117560541) and Wellcome Trust (WT098326MA, WT098325MA).","author":[{"last_name":"Cohen","first_name":"Michael","full_name":"Cohen, Michael H"},{"last_name":"Kicheva","id":"3959A2A0-F248-11E8-B48F-1D18A9856A87","first_name":"Anna","full_name":"Anna Kicheva","orcid":"0000-0003-4509-4998"},{"full_name":"Ribeiro, Ana C","first_name":"Ana","last_name":"Ribeiro"},{"first_name":"Robert","last_name":"Blassberg","full_name":"Blassberg, Robert A"},{"full_name":"Page, Karen M","first_name":"Karen","last_name":"Page"},{"full_name":"Barnes, Chris P","last_name":"Barnes","first_name":"Chris"},{"full_name":"Briscoe, James","first_name":"James","last_name":"Briscoe"}],"day":"02","year":"2015","intvolume":"         6","status":"public","title":"Ptch1 and Gli regulate Shh signalling dynamics via multiple mechanisms","tmp":{"image":"/images/cc_by.png","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"volume":6},{"doi":"10.1242/dev.092726","citation":{"ama":"Kahane N, Ribes V, Kicheva A, Briscoe J, Kalcheim C. The transition from differentiation to growth during dermomyotome-derived myogenesis depends on temporally restricted hedgehog signaling. <i>Development</i>. 2013;140(8):1740-1750. doi:<a href=\"https://doi.org/10.1242/dev.092726\">10.1242/dev.092726</a>","ista":"Kahane N, Ribes V, Kicheva A, Briscoe J, Kalcheim C. 2013. The transition from differentiation to growth during dermomyotome-derived myogenesis depends on temporally restricted hedgehog signaling. Development. 140(8), 1740–1750.","ieee":"N. Kahane, V. Ribes, A. Kicheva, J. Briscoe, and C. Kalcheim, “The transition from differentiation to growth during dermomyotome-derived myogenesis depends on temporally restricted hedgehog signaling,” <i>Development</i>, vol. 140, no. 8. Company of Biologists, pp. 1740–1750, 2013.","mla":"Kahane, Nitza, et al. “The Transition from Differentiation to Growth during Dermomyotome-Derived Myogenesis Depends on Temporally Restricted Hedgehog Signaling.” <i>Development</i>, vol. 140, no. 8, Company of Biologists, 2013, pp. 1740–50, doi:<a href=\"https://doi.org/10.1242/dev.092726\">10.1242/dev.092726</a>.","apa":"Kahane, N., Ribes, V., Kicheva, A., Briscoe, J., &#38; Kalcheim, C. (2013). The transition from differentiation to growth during dermomyotome-derived myogenesis depends on temporally restricted hedgehog signaling. <i>Development</i>. Company of Biologists. <a href=\"https://doi.org/10.1242/dev.092726\">https://doi.org/10.1242/dev.092726</a>","chicago":"Kahane, Nitza, Vanessa Ribes, Anna Kicheva, James Briscoe, and Chaya Kalcheim. “The Transition from Differentiation to Growth during Dermomyotome-Derived Myogenesis Depends on Temporally Restricted Hedgehog Signaling.” <i>Development</i>. Company of Biologists, 2013. <a href=\"https://doi.org/10.1242/dev.092726\">https://doi.org/10.1242/dev.092726</a>.","short":"N. Kahane, V. Ribes, A. Kicheva, J. Briscoe, C. Kalcheim, Development 140 (2013) 1740–1750."},"date_created":"2018-12-11T11:53:41Z","quality_controlled":0,"type":"journal_article","_id":"1726","issue":"8","publication":"Development","extern":1,"author":[{"full_name":"Kahane, Nitza","last_name":"Kahane","first_name":"Nitza"},{"first_name":"Vanessa","last_name":"Ribes","full_name":"Ribes, Vanessa"},{"orcid":"0000-0003-4509-4998","full_name":"Anna Kicheva","first_name":"Anna","id":"3959A2A0-F248-11E8-B48F-1D18A9856A87","last_name":"Kicheva"},{"full_name":"Briscoe, James","first_name":"James","last_name":"Briscoe"},{"full_name":"Kalcheim, Chaya","last_name":"Kalcheim","first_name":"Chaya"}],"acknowledgement":"This study was supported by grants from the Israel Science Foundation (ISF) [11/09 to C.K.]; the Association Francaise contre les Myopathies (AFM) [15642 to C.K.]; the German Research Foundation (DFG) [UN 34/27-1 to C.K.]; the UK Medical Research Council (MRC) [U117560541 to J.B. and A.K.]; Fondation Pour la Recherche Médicale (FRM) (post-doctoral fellowship to V.R.). Deposited in PMC for release after 6 months","year":"2013","day":"18","title":"The transition from differentiation to growth during dermomyotome-derived myogenesis depends on temporally restricted hedgehog signaling","volume":140,"status":"public","intvolume":"       140","page":"1740 - 1750","abstract":[{"lang":"eng","text":"The development of a functional tissue requires coordination of the amplification of progenitors and their differentiation into specific cell types. The molecular basis for this coordination during myotome ontogeny is not well understood. Dermomytome progenitors that colonize the myotome first acquire myocyte identity and subsequently proliferate as Pax7-expressing progenitors before undergoing terminal differentiation. We show that the dynamics of sonic hedgehog (Shh) signaling is crucial for this transition in both avian and mouse embryos. Initially, Shh ligand emanating from notochord/floor plate reaches the dermomyotome, where it both maintains the proliferation of dermomyotome cells and promotes myogenic differentiation of progenitors that colonized the myotome. Interfering with Shh signaling at this stage produces small myotomes and accumulation of Pax7-expressing progenitors. An in vivo reporter of Shh activity combined with mouse genetics revealed the existence of both activator and repressor Shh activities operating on distinct subsets of cells during the epaxial myotomal maturation. In contrast to observations in mice, in avians Shh promotes the differentiation of both epaxial and hypaxial myotome domains. Subsequently, myogenic progenitors become refractory to Shh; this is likely to occur at the level of, or upstream of, smoothened signaling. The end of responsiveness to Shh coincides with, and is thus likely to enable, the transition into the growth phase of the myotome."}],"month":"04","date_published":"2013-04-18T00:00:00Z","publication_status":"published","publisher":"Company of Biologists","publist_id":"5402","date_updated":"2021-01-12T06:52:47Z"},{"page":"387 - 403","month":"05","date_published":"2013-05-01T00:00:00Z","abstract":[{"lang":"eng","text":"Cells at different positions in a developing tissue receive different concentrations of signaling molecules, called morphogens, and this influences their cell fate. Morphogen concentration gradients have been proposed to control patterning as well as growth in many developing tissues. Some outstanding questions about tissue patterning by morphogen gradients are the following: What are the mechanisms that regulate gradient formation and shape? Is the positional information encoded in the gradient sufficiently precise to determine the positions of target gene domain boundaries? What are the temporal dynamics of gradients and how do they relate to patterning and growth? These questions are inherently quantitative in nature and addressing them requires measuring morphogen concentrations in cells, levels of downstream signaling activity, and kinetics of morphogen transport. Here we first present methods for quantifying morphogen gradient shape in which the measurements can be calibrated to reflect actual morphogen concentrations. We then discuss using fluorescence recovery after photobleaching to study the kinetics of morphogen transport at the tissue level. Finally, we present particle tracking as a method to study morphogen intracellular trafficking."}],"date_updated":"2021-01-12T06:52:47Z","publist_id":"5401","publisher":"Cold Spring Harbor Laboratory Press","publication_status":"published","publication":"Cold Spring Harbor Protocols","extern":1,"issue":"5","_id":"1727","type":"journal_article","date_created":"2018-12-11T11:53:41Z","quality_controlled":0,"doi":"10.1101/pdb.top074237","citation":{"mla":"Kicheva, Anna, et al. “Quantitative Imaging of Morphogen Gradients in Drosophila Imaginal Discs.” <i>Cold Spring Harbor Protocols</i>, vol. 8, no. 5, Cold Spring Harbor Laboratory Press, 2013, pp. 387–403, doi:<a href=\"https://doi.org/10.1101/pdb.top074237\">10.1101/pdb.top074237</a>.","ieee":"A. Kicheva, L. Holtzer, O. Wartlick, T. Schmidt, and M. González Gaitán, “Quantitative imaging of morphogen gradients in drosophila imaginal discs,” <i>Cold Spring Harbor Protocols</i>, vol. 8, no. 5. Cold Spring Harbor Laboratory Press, pp. 387–403, 2013.","ista":"Kicheva A, Holtzer L, Wartlick O, Schmidt T, González Gaitán M. 2013. Quantitative imaging of morphogen gradients in drosophila imaginal discs. Cold Spring Harbor Protocols. 8(5), 387–403.","chicago":"Kicheva, Anna, Laurent Holtzer, Ortrud Wartlick, Thomas Schmidt, and Marcos González Gaitán. “Quantitative Imaging of Morphogen Gradients in Drosophila Imaginal Discs.” <i>Cold Spring Harbor Protocols</i>. Cold Spring Harbor Laboratory Press, 2013. <a href=\"https://doi.org/10.1101/pdb.top074237\">https://doi.org/10.1101/pdb.top074237</a>.","short":"A. Kicheva, L. Holtzer, O. Wartlick, T. Schmidt, M. González Gaitán, Cold Spring Harbor Protocols 8 (2013) 387–403.","apa":"Kicheva, A., Holtzer, L., Wartlick, O., Schmidt, T., &#38; González Gaitán, M. (2013). Quantitative imaging of morphogen gradients in drosophila imaginal discs. <i>Cold Spring Harbor Protocols</i>. Cold Spring Harbor Laboratory Press. <a href=\"https://doi.org/10.1101/pdb.top074237\">https://doi.org/10.1101/pdb.top074237</a>","ama":"Kicheva A, Holtzer L, Wartlick O, Schmidt T, González Gaitán M. Quantitative imaging of morphogen gradients in drosophila imaginal discs. <i>Cold Spring Harbor Protocols</i>. 2013;8(5):387-403. doi:<a href=\"https://doi.org/10.1101/pdb.top074237\">10.1101/pdb.top074237</a>"},"author":[{"id":"3959A2A0-F248-11E8-B48F-1D18A9856A87","first_name":"Anna","last_name":"Kicheva","full_name":"Anna Kicheva","orcid":"0000-0003-4509-4998"},{"first_name":"Laurent","last_name":"Holtzer","full_name":"Holtzer, Laurent"},{"full_name":"Wartlick, Ortrud","last_name":"Wartlick","first_name":"Ortrud"},{"last_name":"Schmidt","first_name":"Thomas","full_name":"Schmidt, Thomas S"},{"first_name":"Marcos","last_name":"González Gaitán","full_name":"González-Gaitán, Marcos A"}],"day":"01","year":"2013","status":"public","intvolume":"         8","title":"Quantitative imaging of morphogen gradients in drosophila imaginal discs","volume":8},{"abstract":[{"text":"The spatial organization of cell fates during development involves the interpretation of morphogen gradients by cellular signaling cascades and transcriptional networks. Recent studies use biophysical models, genetics, and quantitative imaging to unravel how tissue-level morphogen behavior arises from subcellular events. Moreover, data from several systems show that morphogen gradients, downstream signaling, and the activity of cell-intrinsic transcriptional networks change dynamically during pattern formation. Studies from Drosophila and now also vertebrates suggest that transcriptional network dynamics are central to the generation of gene expression patterns. Together, this leads to the view that pattern formation is an emergent behavior that results from the coordination of events occurring across molecular, cellular, and tissue scales. The development of novel approaches to study this complex process remains a challenge.","lang":"eng"}],"date_published":"2012-10-12T00:00:00Z","month":"10","publication_status":"published","publisher":"American Association for the Advancement of Science","date_updated":"2021-01-12T06:52:47Z","publist_id":"5404","page":"210 - 212","year":"2012","day":"12","title":"Developmental pattern formation: Insights from physics and biology","volume":338,"intvolume":"       338","status":"public","doi":"10.1126/science.1225182","citation":{"ieee":"A. Kicheva, M. Cohen, and J. Briscoe, “Developmental pattern formation: Insights from physics and biology,” <i>Science</i>, vol. 338, no. 6104. American Association for the Advancement of Science, pp. 210–212, 2012.","ista":"Kicheva A, Cohen M, Briscoe J. 2012. Developmental pattern formation: Insights from physics and biology. Science. 338(6104), 210–212.","mla":"Kicheva, Anna, et al. “Developmental Pattern Formation: Insights from Physics and Biology.” <i>Science</i>, vol. 338, no. 6104, American Association for the Advancement of Science, 2012, pp. 210–12, doi:<a href=\"https://doi.org/10.1126/science.1225182\">10.1126/science.1225182</a>.","apa":"Kicheva, A., Cohen, M., &#38; Briscoe, J. (2012). Developmental pattern formation: Insights from physics and biology. <i>Science</i>. American Association for the Advancement of Science. <a href=\"https://doi.org/10.1126/science.1225182\">https://doi.org/10.1126/science.1225182</a>","short":"A. Kicheva, M. Cohen, J. Briscoe, Science 338 (2012) 210–212.","chicago":"Kicheva, Anna, Michael Cohen, and James Briscoe. “Developmental Pattern Formation: Insights from Physics and Biology.” <i>Science</i>. American Association for the Advancement of Science, 2012. <a href=\"https://doi.org/10.1126/science.1225182\">https://doi.org/10.1126/science.1225182</a>.","ama":"Kicheva A, Cohen M, Briscoe J. Developmental pattern formation: Insights from physics and biology. <i>Science</i>. 2012;338(6104):210-212. doi:<a href=\"https://doi.org/10.1126/science.1225182\">10.1126/science.1225182</a>"},"date_created":"2018-12-11T11:53:40Z","quality_controlled":0,"_id":"1725","issue":"6104","type":"journal_article","publication":"Science","extern":1,"author":[{"id":"3959A2A0-F248-11E8-B48F-1D18A9856A87","first_name":"Anna","last_name":"Kicheva","orcid":"0000-0003-4509-4998","full_name":"Anna Kicheva"},{"full_name":"Cohen, Michael H","last_name":"Cohen","first_name":"Michael"},{"last_name":"Briscoe","first_name":"James","full_name":"Briscoe, James"}],"acknowledgement":"Funding provided by the Medical Research Council (UK). "},{"scopus_import":1,"page":"527 - 532","date_published":"2012-12-01T00:00:00Z","month":"12","abstract":[{"lang":"eng","text":"Morphogen gradients regulate the patterning and growth of many tissues, hence a key question is how they are established and maintained during development. Theoretical descriptions have helped to explain how gradient shape is controlled by the rates of morphogen production, spreading and degradation. These effective rates have been measured using fluorescence recovery after photobleaching (FRAP) and photoactivation. To unravel which molecular events determine the effective rates, such tissue-level assays have been combined with genetic analysis, high-resolution assays, and models that take into account interactions with receptors, extracellular components and trafficking. Nevertheless, because of the natural and experimental data variability, and the underlying assumptions of transport models, it remains challenging to conclusively distinguish between cellular mechanisms."}],"publisher":"Elsevier","date_updated":"2021-01-12T07:40:09Z","publist_id":"3739","user_id":"3E5EF7F0-F248-11E8-B48F-1D18A9856A87","publication_status":"published","issue":"6","_id":"2970","type":"journal_article","publication":"Current Opinion in Genetics & Development","citation":{"short":"A. Kicheva, M.T. Bollenbach, O. Wartlick, F. Julicher, M. Gonzalez Gaitan, Current Opinion in Genetics &#38; Development 22 (2012) 527–532.","chicago":"Kicheva, Anna, Mark Tobias Bollenbach, Ortrud Wartlick, Frank Julicher, and Marcos Gonzalez Gaitan. “Investigating the Principles of Morphogen Gradient Formation: From Tissues to Cells.” <i>Current Opinion in Genetics &#38; Development</i>. Elsevier, 2012. <a href=\"https://doi.org/10.1016/j.gde.2012.08.004\">https://doi.org/10.1016/j.gde.2012.08.004</a>.","apa":"Kicheva, A., Bollenbach, M. T., Wartlick, O., Julicher, F., &#38; Gonzalez Gaitan, M. (2012). Investigating the principles of morphogen gradient formation: from tissues to cells. <i>Current Opinion in Genetics &#38; Development</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.gde.2012.08.004\">https://doi.org/10.1016/j.gde.2012.08.004</a>","mla":"Kicheva, Anna, et al. “Investigating the Principles of Morphogen Gradient Formation: From Tissues to Cells.” <i>Current Opinion in Genetics &#38; Development</i>, vol. 22, no. 6, Elsevier, 2012, pp. 527–32, doi:<a href=\"https://doi.org/10.1016/j.gde.2012.08.004\">10.1016/j.gde.2012.08.004</a>.","ista":"Kicheva A, Bollenbach MT, Wartlick O, Julicher F, Gonzalez Gaitan M. 2012. Investigating the principles of morphogen gradient formation: from tissues to cells. Current Opinion in Genetics &#38; Development. 22(6), 527–532.","ieee":"A. Kicheva, M. T. Bollenbach, O. Wartlick, F. Julicher, and M. Gonzalez Gaitan, “Investigating the principles of morphogen gradient formation: from tissues to cells,” <i>Current Opinion in Genetics &#38; Development</i>, vol. 22, no. 6. Elsevier, pp. 527–532, 2012.","ama":"Kicheva A, Bollenbach MT, Wartlick O, Julicher F, Gonzalez Gaitan M. Investigating the principles of morphogen gradient formation: from tissues to cells. <i>Current Opinion in Genetics &#38; Development</i>. 2012;22(6):527-532. doi:<a href=\"https://doi.org/10.1016/j.gde.2012.08.004\">10.1016/j.gde.2012.08.004</a>"},"doi":"10.1016/j.gde.2012.08.004","oa_version":"None","date_created":"2018-12-11T12:00:37Z","quality_controlled":"1","department":[{"_id":"ToBo"}],"acknowledgement":"AK is currently supported by an MRC CDF. MGG and OW were supported by the Swiss National Science Foundation, grants from the Swiss SystemsX.ch initiative, LipidX-2008/011, an ERC advanced investigator grant and the Polish-Swiss research program.","author":[{"orcid":"0000-0003-4509-4998","full_name":"Kicheva, Anna","last_name":"Kicheva","first_name":"Anna","id":"3959A2A0-F248-11E8-B48F-1D18A9856A87"},{"id":"3E6DB97A-F248-11E8-B48F-1D18A9856A87","first_name":"Mark Tobias","last_name":"Bollenbach","full_name":"Bollenbach, Mark Tobias","orcid":"0000-0003-4398-476X"},{"full_name":"Wartlick, Ortrud","last_name":"Wartlick","first_name":"Ortrud"},{"full_name":"Julicher, Frank","first_name":"Frank","last_name":"Julicher"},{"full_name":"Gonzalez Gaitan, Marcos","last_name":"Gonzalez Gaitan","first_name":"Marcos"}],"language":[{"iso":"eng"}],"day":"01","year":"2012","intvolume":"        22","status":"public","volume":22,"title":"Investigating the principles of morphogen gradient formation: from tissues to cells"},{"status":"public","intvolume":"         2","volume":2,"title":"Epithelial organisation revealed by a network of cellular contacts","year":"2011","day":"01","acknowledgement":"We acknowledge the MRC for funding, M.M.B. acknowledges Darwin College, EMBO YIP and Schlumberger Ltd for support. L.M.E. is funded by the Marie Curie and the EMBO fellowships. L.d.F.C. is grateful to FAPESP (05/00587-5) and CNPq (301303/06-1) for financial support. Part of this work was performed during a Visiting Scholarship to L.d.F.C. from St Catharine's College, University of Cambridge. J.B. is supported by the MRC (UK) and A.K. by a FEBS fellowship","author":[{"full_name":"Escudero, Luis M","last_name":"Escudero","first_name":"Luis"},{"full_name":"Costa, Luciano","last_name":"Costa","first_name":"Luciano"},{"last_name":"Kicheva","id":"3959A2A0-F248-11E8-B48F-1D18A9856A87","first_name":"Anna","orcid":"0000-0003-4509-4998","full_name":"Anna Kicheva"},{"full_name":"Briscoe, James","first_name":"James","last_name":"Briscoe"},{"last_name":"Freeman","first_name":"Matthew","full_name":"Freeman, Matthew"},{"full_name":"Babu, Madan M","last_name":"Babu","first_name":"Madan"}],"_id":"1723","type":"journal_article","issue":"1","publication":"Nature Communications","extern":1,"citation":{"mla":"Escudero, Luis, et al. “Epithelial Organisation Revealed by a Network of Cellular Contacts.” <i>Nature Communications</i>, vol. 2, no. 1, Nature Publishing Group, 2011, doi:<a href=\"https://doi.org/10.1038/ncomms1536\">10.1038/ncomms1536</a>.","ieee":"L. Escudero, L. Costa, A. Kicheva, J. Briscoe, M. Freeman, and M. Babu, “Epithelial organisation revealed by a network of cellular contacts,” <i>Nature Communications</i>, vol. 2, no. 1. Nature Publishing Group, 2011.","ista":"Escudero L, Costa L, Kicheva A, Briscoe J, Freeman M, Babu M. 2011. Epithelial organisation revealed by a network of cellular contacts. Nature Communications. 2(1).","short":"L. Escudero, L. Costa, A. Kicheva, J. Briscoe, M. Freeman, M. Babu, Nature Communications 2 (2011).","chicago":"Escudero, Luis, Luciano Costa, Anna Kicheva, James Briscoe, Matthew Freeman, and Madan Babu. “Epithelial Organisation Revealed by a Network of Cellular Contacts.” <i>Nature Communications</i>. Nature Publishing Group, 2011. <a href=\"https://doi.org/10.1038/ncomms1536\">https://doi.org/10.1038/ncomms1536</a>.","apa":"Escudero, L., Costa, L., Kicheva, A., Briscoe, J., Freeman, M., &#38; Babu, M. (2011). Epithelial organisation revealed by a network of cellular contacts. <i>Nature Communications</i>. Nature Publishing Group. <a href=\"https://doi.org/10.1038/ncomms1536\">https://doi.org/10.1038/ncomms1536</a>","ama":"Escudero L, Costa L, Kicheva A, Briscoe J, Freeman M, Babu M. Epithelial organisation revealed by a network of cellular contacts. <i>Nature Communications</i>. 2011;2(1). doi:<a href=\"https://doi.org/10.1038/ncomms1536\">10.1038/ncomms1536</a>"},"doi":"10.1038/ncomms1536","quality_controlled":0,"date_created":"2018-12-11T11:53:40Z","publisher":"Nature Publishing Group","date_updated":"2021-01-12T06:52:46Z","publist_id":"5405","publication_status":"published","date_published":"2011-01-01T00:00:00Z","month":"01","abstract":[{"lang":"eng","text":"The emergence of differences in the arrangement of cells is the first step towards the establishment of many organs. Understanding this process is limited by the lack of systematic characterization of epithelial organisation. Here we apply network theory at the scale of individual cells to uncover patterns in cell-to-cell contacts that govern epithelial organisation. We provide an objective characterisation of epithelia using network representation, where cells are nodes and cell contacts are links. The features of individual cells, together with attributes of the cellular network, produce a defining signature that distinguishes epithelia from different organs, species, developmental stages and genetic conditions. The approach permits characterization, quantification and classification of normal and perturbed epithelia, and establishes a framework for understanding molecular mechanisms that underpin the architecture of complex tissues."}]},{"acknowledgement":"P.M., T.B., and F.J. were supported by the Max-Planck-Gesellschaft. O.W., A.K., C.S., and M.G.-G. were supported by Geneva University and by European Research Council advanced investigator grant (SARA), SystemsX (LipidX), Swiss National Science Foundation (SNF), National Centre of Competence in Research (NCCR) chemical biology and Frontiers in Genetics and R'equip grants","author":[{"full_name":"Wartlick, Ortrud","last_name":"Wartlick","first_name":"Ortrud"},{"full_name":"Mumcu, Peer","last_name":"Mumcu","first_name":"Peer"},{"last_name":"Kicheva","id":"3959A2A0-F248-11E8-B48F-1D18A9856A87","first_name":"Anna","full_name":"Anna Kicheva","orcid":"0000-0003-4509-4998"},{"first_name":"Thomas","last_name":"Bittig","full_name":"Bittig, Thomas"},{"full_name":"Seum, Carole","last_name":"Seum","first_name":"Carole"},{"full_name":"Jülicher, Frank","first_name":"Frank","last_name":"Jülicher"},{"first_name":"Marcos","last_name":"González Gaitán","full_name":"González-Gaitán, Marcos A"}],"publication":"Science","extern":1,"_id":"1724","issue":"6021","type":"journal_article","date_created":"2018-12-11T11:53:40Z","quality_controlled":0,"citation":{"ama":"Wartlick O, Mumcu P, Kicheva A, et al. Dynamics of Dpp signaling and proliferation control. <i>Science</i>. 2011;331(6021):1154-1159. doi:<a href=\"https://doi.org/10.1126/science.1200037\">10.1126/science.1200037</a>","apa":"Wartlick, O., Mumcu, P., Kicheva, A., Bittig, T., Seum, C., Jülicher, F., &#38; González Gaitán, M. (2011). Dynamics of Dpp signaling and proliferation control. <i>Science</i>. American Association for the Advancement of Science. <a href=\"https://doi.org/10.1126/science.1200037\">https://doi.org/10.1126/science.1200037</a>","short":"O. Wartlick, P. Mumcu, A. Kicheva, T. Bittig, C. Seum, F. Jülicher, M. González Gaitán, Science 331 (2011) 1154–1159.","chicago":"Wartlick, Ortrud, Peer Mumcu, Anna Kicheva, Thomas Bittig, Carole Seum, Frank Jülicher, and Marcos González Gaitán. “Dynamics of Dpp Signaling and Proliferation Control.” <i>Science</i>. American Association for the Advancement of Science, 2011. <a href=\"https://doi.org/10.1126/science.1200037\">https://doi.org/10.1126/science.1200037</a>.","ieee":"O. Wartlick <i>et al.</i>, “Dynamics of Dpp signaling and proliferation control,” <i>Science</i>, vol. 331, no. 6021. American Association for the Advancement of Science, pp. 1154–1159, 2011.","ista":"Wartlick O, Mumcu P, Kicheva A, Bittig T, Seum C, Jülicher F, González Gaitán M. 2011. Dynamics of Dpp signaling and proliferation control. Science. 331(6021), 1154–1159.","mla":"Wartlick, Ortrud, et al. “Dynamics of Dpp Signaling and Proliferation Control.” <i>Science</i>, vol. 331, no. 6021, American Association for the Advancement of Science, 2011, pp. 1154–59, doi:<a href=\"https://doi.org/10.1126/science.1200037\">10.1126/science.1200037</a>."},"doi":"10.1126/science.1200037","status":"public","intvolume":"       331","volume":331,"title":"Dynamics of Dpp signaling and proliferation control","day":"04","year":"2011","page":"1154 - 1159","date_updated":"2021-01-12T06:52:46Z","publist_id":"5406","publisher":"American Association for the Advancement of Science","publication_status":"published","date_published":"2011-03-04T00:00:00Z","month":"03","abstract":[{"text":"Morphogens, such as Decapentaplegic (Dpp) in the fly imaginal discs, form graded concentration profiles that control patterning and growth of developing organs. In the imaginal discs, proliferative growth is homogeneous in space, posing the conundrum of how morphogen concentration gradients could control position-independent growth. To understand the mechanism of proliferation control by the Dpp gradient, we quantified Dpp concentration and signaling levels during wing disc growth. Both Dpp concentration and signaling gradients scale with tissue size during development. On average, cells divide when Dpp signaling levels have increased by 50%. Our observations are consistent with a growth control mechanism based on temporal changes of cellular morphogen signaling levels. For a scaling gradient, this mechanism generates position-independent growth rates.","lang":"eng"}]}]