[{"month":"03","date_published":"2023-03-16T00:00:00Z","ddc":["570"],"tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"scopus_import":"1","has_accepted_license":"1","date_updated":"2023-08-01T12:39:58Z","citation":{"ama":"Viljakainen L, Fürst M, Grasse AV, et al. Antiviral immune response reveals host-specific virus infections in natural ant populations. <i>Frontiers in Microbiology</i>. 2023;14. doi:<a href=\"https://doi.org/10.3389/fmicb.2023.1119002\">10.3389/fmicb.2023.1119002</a>","ieee":"L. Viljakainen <i>et al.</i>, “Antiviral immune response reveals host-specific virus infections in natural ant populations,” <i>Frontiers in Microbiology</i>, vol. 14. Frontiers, 2023.","mla":"Viljakainen, Lumi, et al. “Antiviral Immune Response Reveals Host-Specific Virus Infections in Natural Ant Populations.” <i>Frontiers in Microbiology</i>, vol. 14, 1119002, Frontiers, 2023, doi:<a href=\"https://doi.org/10.3389/fmicb.2023.1119002\">10.3389/fmicb.2023.1119002</a>.","apa":"Viljakainen, L., Fürst, M., Grasse, A. V., Jurvansuu, J., Oh, J., Tolonen, L., … Cremer, S. (2023). Antiviral immune response reveals host-specific virus infections in natural ant populations. <i>Frontiers in Microbiology</i>. Frontiers. <a href=\"https://doi.org/10.3389/fmicb.2023.1119002\">https://doi.org/10.3389/fmicb.2023.1119002</a>","short":"L. Viljakainen, M. Fürst, A.V. Grasse, J. Jurvansuu, J. Oh, L. Tolonen, T. Eder, T. Rattei, S. Cremer, Frontiers in Microbiology 14 (2023).","ista":"Viljakainen L, Fürst M, Grasse AV, Jurvansuu J, Oh J, Tolonen L, Eder T, Rattei T, Cremer S. 2023. Antiviral immune response reveals host-specific virus infections in natural ant populations. Frontiers in Microbiology. 14, 1119002.","chicago":"Viljakainen, Lumi, Matthias Fürst, Anna V Grasse, Jaana Jurvansuu, Jinook Oh, Lassi Tolonen, Thomas Eder, Thomas Rattei, and Sylvia Cremer. “Antiviral Immune Response Reveals Host-Specific Virus Infections in Natural Ant Populations.” <i>Frontiers in Microbiology</i>. Frontiers, 2023. <a href=\"https://doi.org/10.3389/fmicb.2023.1119002\">https://doi.org/10.3389/fmicb.2023.1119002</a>."},"pmid":1,"type":"journal_article","article_number":"1119002","oa_version":"Published Version","file_date_updated":"2023-04-17T07:49:09Z","article_type":"original","doi":"10.3389/fmicb.2023.1119002","intvolume":"        14","title":"Antiviral immune response reveals host-specific virus infections in natural ant populations","acknowledgement":"We thank D.J. Obbard for sharing the details of the dual RNA-seq/sRNA-seq approach, S.\r\nMetzler and R. Ferrigato for the photographs (Figure 1), M. Konrad, B. Casillas-Perez, C.D.\r\nPull and X. Espadaler for help with ant collection, and the Social Immunity Team at IST\r\nAustria, in particular J. Robb, A. Franschitz, E. Naderlinger, E. Dawson and B. Casillas-Perez\r\nfor support and comments on the manuscript. The study was funded by the Austrian Science\r\nFund (FWF; M02076-B25 to MAF) and the Academy of Finland (343022 to LV). ","language":[{"iso":"eng"}],"year":"2023","publication":"Frontiers in Microbiology","article_processing_charge":"Yes (via OA deal)","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","publication_status":"published","abstract":[{"lang":"eng","text":"Hosts can carry many viruses in their bodies, but not all of them cause disease. We studied ants as a social host to determine both their overall viral repertoire and the subset of actively infecting viruses across natural populations of three subfamilies: the Argentine ant (Linepithema humile, Dolichoderinae), the invasive garden ant (Lasius neglectus, Formicinae) and the red ant (Myrmica rubra, Myrmicinae). We used a dual sequencing strategy to reconstruct complete virus genomes by RNA-seq and to simultaneously determine the small interfering RNAs (siRNAs) by small RNA sequencing (sRNA-seq), which constitute the host antiviral RNAi immune response. This approach led to the discovery of 41 novel viruses in ants and revealed a host ant-specific RNAi response (21 vs. 22 nt siRNAs) in the different ant species. The efficiency of the RNAi response (sRNA/RNA read count ratio) depended on the virus and the respective ant species, but not its population. Overall, we found the highest virus abundance and diversity per population in Li. humile, followed by La. neglectus and M. rubra. Argentine ants also shared a high proportion of viruses between populations, whilst overlap was nearly absent in M. rubra. Only one of the 59 viruses was found to infect two of the ant species as hosts, revealing high host-specificity in active infections. In contrast, six viruses actively infected one ant species, but were found as contaminants only in the others. Disentangling spillover of disease-causing infection from non-infecting contamination across species is providing relevant information for disease ecology and ecosystem management."}],"_id":"12469","project":[{"call_identifier":"FWF","grant_number":"M02076","_id":"25DF61D8-B435-11E9-9278-68D0E5697425","name":"Viral pathogens and social immunity in ants"}],"volume":14,"publication_identifier":{"eissn":["1664-302X"]},"author":[{"full_name":"Viljakainen, Lumi","last_name":"Viljakainen","first_name":"Lumi"},{"id":"393B1196-F248-11E8-B48F-1D18A9856A87","first_name":"Matthias","orcid":"0000-0002-3712-925X","last_name":"Fürst","full_name":"Fürst, Matthias"},{"id":"406F989C-F248-11E8-B48F-1D18A9856A87","first_name":"Anna V","last_name":"Grasse","full_name":"Grasse, Anna V"},{"first_name":"Jaana","last_name":"Jurvansuu","full_name":"Jurvansuu, Jaana"},{"full_name":"Oh, Jinook","id":"403169A4-080F-11EA-9993-BF3F3DDC885E","first_name":"Jinook","last_name":"Oh","orcid":"0000-0001-7425-2372"},{"last_name":"Tolonen","first_name":"Lassi","full_name":"Tolonen, Lassi"},{"full_name":"Eder, Thomas","last_name":"Eder","first_name":"Thomas"},{"full_name":"Rattei, Thomas","first_name":"Thomas","last_name":"Rattei"},{"full_name":"Cremer, Sylvia","first_name":"Sylvia","last_name":"Cremer","orcid":"0000-0002-2193-3868","id":"2F64EC8C-F248-11E8-B48F-1D18A9856A87"}],"external_id":{"pmid":["PPR559293 "],"isi":["000961542100001"]},"quality_controlled":"1","oa":1,"isi":1,"day":"16","department":[{"_id":"SyCr"}],"status":"public","date_created":"2023-01-31T08:13:40Z","file":[{"relation":"main_file","file_id":"12843","file_size":4866332,"content_type":"application/pdf","date_updated":"2023-04-17T07:49:09Z","creator":"dernst","success":1,"checksum":"cd52292963acce1111634d9fac08c699","date_created":"2023-04-17T07:49:09Z","file_name":"2023_FrontMicrobiology_Viljakainen.pdf","access_level":"open_access"}],"publisher":"Frontiers"},{"quality_controlled":"1","department":[{"_id":"SyCr"}],"day":"07","isi":1,"date_created":"2018-12-11T11:48:36Z","status":"public","publisher":"Annual Reviews","page":"105 - 123","publication_status":"published","user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1","_id":"806","abstract":[{"text":"Social insect colonies have evolved many collectively performed adaptations that reduce the impact of infectious disease and that are expected to maximize their fitness. This colony-level protection is termed social immunity, and it enhances the health and survival of the colony. In this review, we address how social immunity emerges from its mechanistic components to produce colony-level disease avoidance, resistance, and tolerance. To understand the evolutionary causes and consequences of social immunity, we highlight the need for studies that evaluate the effects of social immunity on colony fitness. We discuss the role that host life history and ecology have on predicted eco-evolutionary dynamics, which differ among the social insect lineages. Throughout the review, we highlight current gaps in our knowledge and promising avenues for future research, which we hope will bring us closer to an integrated understanding of socio-eco-evo-immunology.","lang":"eng"}],"publication_identifier":{"issn":["1545-4487"]},"volume":63,"author":[{"full_name":"Cremer, Sylvia","id":"2F64EC8C-F248-11E8-B48F-1D18A9856A87","first_name":"Sylvia","orcid":"0000-0002-2193-3868","last_name":"Cremer"},{"full_name":"Pull, Christopher","id":"3C7F4840-F248-11E8-B48F-1D18A9856A87","first_name":"Christopher","last_name":"Pull","orcid":"0000-0003-1122-3982"},{"full_name":"Fürst, Matthias","first_name":"Matthias","orcid":"0000-0002-3712-925X","last_name":"Fürst","id":"393B1196-F248-11E8-B48F-1D18A9856A87"}],"external_id":{"isi":["000424633700008"]},"title":"Social immunity: Emergence and evolution of colony-level disease protection","intvolume":"        63","year":"2018","language":[{"iso":"eng"}],"publication":"Annual Review of Entomology","article_processing_charge":"No","scopus_import":"1","month":"01","date_published":"2018-01-07T00:00:00Z","type":"journal_article","date_updated":"2023-09-19T09:29:45Z","citation":{"chicago":"Cremer, Sylvia, Christopher Pull, and Matthias Fürst. “Social Immunity: Emergence and Evolution of Colony-Level Disease Protection.” <i>Annual Review of Entomology</i>. Annual Reviews, 2018. <a href=\"https://doi.org/10.1146/annurev-ento-020117-043110\">https://doi.org/10.1146/annurev-ento-020117-043110</a>.","ista":"Cremer S, Pull C, Fürst M. 2018. Social immunity: Emergence and evolution of colony-level disease protection. Annual Review of Entomology. 63, 105–123.","short":"S. Cremer, C. Pull, M. Fürst, Annual Review of Entomology 63 (2018) 105–123.","apa":"Cremer, S., Pull, C., &#38; Fürst, M. (2018). Social immunity: Emergence and evolution of colony-level disease protection. <i>Annual Review of Entomology</i>. Annual Reviews. <a href=\"https://doi.org/10.1146/annurev-ento-020117-043110\">https://doi.org/10.1146/annurev-ento-020117-043110</a>","mla":"Cremer, Sylvia, et al. “Social Immunity: Emergence and Evolution of Colony-Level Disease Protection.” <i>Annual Review of Entomology</i>, vol. 63, Annual Reviews, 2018, pp. 105–23, doi:<a href=\"https://doi.org/10.1146/annurev-ento-020117-043110\">10.1146/annurev-ento-020117-043110</a>.","ieee":"S. Cremer, C. Pull, and M. Fürst, “Social immunity: Emergence and evolution of colony-level disease protection,” <i>Annual Review of Entomology</i>, vol. 63. Annual Reviews, pp. 105–123, 2018.","ama":"Cremer S, Pull C, Fürst M. Social immunity: Emergence and evolution of colony-level disease protection. <i>Annual Review of Entomology</i>. 2018;63:105-123. doi:<a href=\"https://doi.org/10.1146/annurev-ento-020117-043110\">10.1146/annurev-ento-020117-043110</a>"},"oa_version":"None","doi":"10.1146/annurev-ento-020117-043110","publist_id":"6844","related_material":{"record":[{"relation":"dissertation_contains","id":"819","status":"public"}]}},{"oa":1,"issue":"1833","quality_controlled":"1","department":[{"_id":"SyCr"}],"day":"29","date_created":"2018-12-11T11:51:00Z","status":"public","publisher":"Royal Society, The","file":[{"file_id":"4708","relation":"main_file","creator":"system","date_updated":"2020-07-14T12:44:42Z","content_type":"application/pdf","file_size":796872,"date_created":"2018-12-12T10:08:46Z","checksum":"0b0d1be38b497d004064650acb3baced","access_level":"open_access","file_name":"IST-2016-701-v1+1_20160811.full.pdf"}],"publication_status":"published","user_id":"3E5EF7F0-F248-11E8-B48F-1D18A9856A87","_id":"1262","abstract":[{"text":"Emerging infectious diseases (EIDs) have contributed significantly to the current biodiversity crisis, leading to widespread epidemics and population loss. Owing to genetic variation in pathogen virulence, a complete understanding of species decline requires the accurate identification and characterization of EIDs. We explore this issue in the Western honeybee, where increasing mortality of populations in the Northern Hemisphere has caused major concern. Specifically, we investigate the importance of genetic identity of the main suspect in mortality, deformed wing virus (DWV), in driving honeybee loss. Using laboratory experiments and a systematic field survey, we demonstrate that an emerging DWV genotype (DWV-B) is more virulent than the established DWV genotype (DWV-A) and is widespread in the landscape. Furthermore, we show in a simple model that colonies infected with DWV-B collapse sooner than colonies infected with DWV-A. We also identify potential for rapid DWV evolution by revealing extensive genome-wide recombination in vivo. The emergence of DWV-B in naive honeybee populations, including via recombination with DWV-A, could be of significant ecological and economic importance. Our findings emphasize that knowledge of pathogen genetic identity and diversity is critical to understanding drivers of species decline.","lang":"eng"}],"volume":283,"author":[{"first_name":"Dino","last_name":"Mcmahon","full_name":"Mcmahon, Dino"},{"first_name":"Myrsini","last_name":"Natsopoulou","full_name":"Natsopoulou, Myrsini"},{"last_name":"Doublet","first_name":"Vincent","full_name":"Doublet, Vincent"},{"full_name":"Fürst, Matthias","first_name":"Matthias","last_name":"Fürst","orcid":"0000-0002-3712-925X","id":"393B1196-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Weging, Silvio","last_name":"Weging","first_name":"Silvio"},{"last_name":"Brown","first_name":"Mark","full_name":"Brown, Mark"},{"full_name":"Gogol Döring, Andreas","first_name":"Andreas","last_name":"Gogol Döring"},{"first_name":"Robert","last_name":"Paxton","full_name":"Paxton, Robert"}],"title":"Elevated virulence of an emerging viral genotype as a driver of honeybee loss","intvolume":"       283","acknowledgement":"This work was supported by the Federal Ministry of Food, Agriculture and Consumer Protection (Germany): Fit Bee project (grant 511-06.01-28-1-71.007-10), the EU: BeeDoc (grant 244956), iDiv (2013 NGS-Fast Track grant W47004118) and the Insect Pollinators Initiative (IPI grant BB/I000100/1 and BB/I000151/1). The IPI is funded jointly by the Biotechnology and Biological Sciences Research Council, the Department for Environment, Food and Rural Affairs, the Natural Environment Research Council, the Scottish Government and the Wellcome Trust, under the Living with Environmental Change Partnership. We thank A. Abrahams, M. Husemann and A. Soro\r\nfor support in obtaining\r\nV.  destructor\r\n-free honeybees; and BBKA\r\nPresident D. Aston for access to records of colony overwinter\r\n2011–2012 mortality in the UK. We also thank the anonymous refe-\r\nrees and Stephen Martin for comments that led to substantial\r\nimprovement of the manuscript.","pubrep_id":"701","year":"2016","language":[{"iso":"eng"}],"publication":"Proceedings of the Royal Society of London Series B Biological Sciences","scopus_import":1,"tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"ddc":["576","592"],"month":"06","date_published":"2016-06-29T00:00:00Z","article_number":"20160811","type":"journal_article","date_updated":"2023-02-23T14:05:30Z","citation":{"chicago":"Mcmahon, Dino, Myrsini Natsopoulou, Vincent Doublet, Matthias Fürst, Silvio Weging, Mark Brown, Andreas Gogol Döring, and Robert Paxton. “Elevated Virulence of an Emerging Viral Genotype as a Driver of Honeybee Loss.” <i>Proceedings of the Royal Society of London Series B Biological Sciences</i>. Royal Society, The, 2016. <a href=\"https://doi.org/10.1098/rspb.2016.0811\">https://doi.org/10.1098/rspb.2016.0811</a>.","ista":"Mcmahon D, Natsopoulou M, Doublet V, Fürst M, Weging S, Brown M, Gogol Döring A, Paxton R. 2016. Elevated virulence of an emerging viral genotype as a driver of honeybee loss. Proceedings of the Royal Society of London Series B Biological Sciences. 283(1833), 20160811.","short":"D. Mcmahon, M. Natsopoulou, V. Doublet, M. Fürst, S. Weging, M. Brown, A. Gogol Döring, R. Paxton, Proceedings of the Royal Society of London Series B Biological Sciences 283 (2016).","apa":"Mcmahon, D., Natsopoulou, M., Doublet, V., Fürst, M., Weging, S., Brown, M., … Paxton, R. (2016). Elevated virulence of an emerging viral genotype as a driver of honeybee loss. <i>Proceedings of the Royal Society of London Series B Biological Sciences</i>. Royal Society, The. <a href=\"https://doi.org/10.1098/rspb.2016.0811\">https://doi.org/10.1098/rspb.2016.0811</a>","mla":"Mcmahon, Dino, et al. “Elevated Virulence of an Emerging Viral Genotype as a Driver of Honeybee Loss.” <i>Proceedings of the Royal Society of London Series B Biological Sciences</i>, vol. 283, no. 1833, 20160811, Royal Society, The, 2016, doi:<a href=\"https://doi.org/10.1098/rspb.2016.0811\">10.1098/rspb.2016.0811</a>.","ieee":"D. Mcmahon <i>et al.</i>, “Elevated virulence of an emerging viral genotype as a driver of honeybee loss,” <i>Proceedings of the Royal Society of London Series B Biological Sciences</i>, vol. 283, no. 1833. Royal Society, The, 2016.","ama":"Mcmahon D, Natsopoulou M, Doublet V, et al. Elevated virulence of an emerging viral genotype as a driver of honeybee loss. <i>Proceedings of the Royal Society of London Series B Biological Sciences</i>. 2016;283(1833). doi:<a href=\"https://doi.org/10.1098/rspb.2016.0811\">10.1098/rspb.2016.0811</a>"},"has_accepted_license":"1","file_date_updated":"2020-07-14T12:44:42Z","oa_version":"Published Version","doi":"10.1098/rspb.2016.0811","publist_id":"6060","related_material":{"record":[{"status":"public","id":"9704","relation":"research_data"}]}},{"file":[{"checksum":"c27d898598a1e3d7f629607a309254e1","date_created":"2018-12-12T10:17:19Z","file_name":"IST-2016-584-v1+1_peerj-1865.pdf","access_level":"open_access","relation":"main_file","file_id":"5272","file_size":1216360,"content_type":"application/pdf","creator":"system","date_updated":"2020-07-14T12:44:53Z"}],"publisher":"PeerJ","date_created":"2018-12-11T11:51:59Z","status":"public","day":"01","department":[{"_id":"SyCr"}],"quality_controlled":"1","oa":1,"issue":"3","author":[{"first_name":"András","last_name":"Tartally","full_name":"Tartally, András"},{"full_name":"Kelager, Andreas","first_name":"Andreas","last_name":"Kelager"},{"first_name":"Matthias","last_name":"Fürst","orcid":"0000-0002-3712-925X","id":"393B1196-F248-11E8-B48F-1D18A9856A87","full_name":"Fürst, Matthias"},{"last_name":"Nash","first_name":"David","full_name":"Nash, David"}],"volume":2016,"abstract":[{"text":"The rare socially parasitic butterfly Maculinea alcon occurs in two forms, which are characteristic of hygric or xeric habitats and which exploit different host plants and host ants. The status of these two forms has been the subject of considerable controversy. Populations of the two forms are usually spatially distinct, but at Răscruci in Romania both forms occur on the same site (syntopically). We examined the genetic differentiation between the two forms using eight microsatellite markers, and compared with a nearby hygric site, Şardu. Our results showed that while the two forms are strongly differentiated at Răscruci, it is the xeric form there that is most similar to the hygric form at Şardu, and Bayesian clustering algorithms suggest that these two populations have exchanged genes relatively recently. We found strong evidence for population substructuring, caused by high within host ant nest relatedness, indicating very limited dispersal of most ovipositing females, but not association with particular host ant species. Our results are consistent with the results of larger scale phylogeographic studies that suggest that the two forms represent local ecotypes specialising on different host plants, each with a distinct flowering phenology, providing a temporal rather than spatial barrier to gene flow.","lang":"eng"}],"_id":"1431","publication_status":"published","user_id":"3E5EF7F0-F248-11E8-B48F-1D18A9856A87","publication":"PeerJ","year":"2016","language":[{"iso":"eng"}],"pubrep_id":"584","title":"Host plant use drives genetic differentiation in syntopic populations of Maculinea alcon","intvolume":"      2016","publist_id":"5767","doi":"10.7717/peerj.1865","oa_version":"Published Version","file_date_updated":"2020-07-14T12:44:53Z","type":"journal_article","has_accepted_license":"1","citation":{"short":"A. Tartally, A. Kelager, M. Fürst, D. Nash, PeerJ 2016 (2016).","apa":"Tartally, A., Kelager, A., Fürst, M., &#38; Nash, D. (2016). Host plant use drives genetic differentiation in syntopic populations of Maculinea alcon. <i>PeerJ</i>. PeerJ. <a href=\"https://doi.org/10.7717/peerj.1865\">https://doi.org/10.7717/peerj.1865</a>","chicago":"Tartally, András, Andreas Kelager, Matthias Fürst, and David Nash. “Host Plant Use Drives Genetic Differentiation in Syntopic Populations of Maculinea Alcon.” <i>PeerJ</i>. PeerJ, 2016. <a href=\"https://doi.org/10.7717/peerj.1865\">https://doi.org/10.7717/peerj.1865</a>.","ista":"Tartally A, Kelager A, Fürst M, Nash D. 2016. Host plant use drives genetic differentiation in syntopic populations of Maculinea alcon. PeerJ. 2016(3), 1865.","ama":"Tartally A, Kelager A, Fürst M, Nash D. Host plant use drives genetic differentiation in syntopic populations of Maculinea alcon. <i>PeerJ</i>. 2016;2016(3). doi:<a href=\"https://doi.org/10.7717/peerj.1865\">10.7717/peerj.1865</a>","mla":"Tartally, András, et al. “Host Plant Use Drives Genetic Differentiation in Syntopic Populations of Maculinea Alcon.” <i>PeerJ</i>, vol. 2016, no. 3, 1865, PeerJ, 2016, doi:<a href=\"https://doi.org/10.7717/peerj.1865\">10.7717/peerj.1865</a>.","ieee":"A. Tartally, A. Kelager, M. Fürst, and D. Nash, “Host plant use drives genetic differentiation in syntopic populations of Maculinea alcon,” <i>PeerJ</i>, vol. 2016, no. 3. PeerJ, 2016."},"date_updated":"2021-01-12T06:50:41Z","article_number":"1865","ddc":["570"],"month":"01","date_published":"2016-01-01T00:00:00Z","scopus_import":1,"tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"}},{"year":"2016","date_created":"2021-07-23T08:30:38Z","status":"public","article_processing_charge":"No","publisher":"Dryad","oa":1,"title":"Data from: Elevated virulence of an emerging viral genotype as a driver of honeybee loss","main_file_link":[{"open_access":"1","url":"https://doi.org/10.5061/dryad.cq7t1"}],"department":[{"_id":"SyCr"}],"day":"06","oa_version":"Published Version","doi":"10.5061/dryad.cq7t1","related_material":{"record":[{"status":"public","relation":"used_in_publication","id":"1262"}]},"author":[{"full_name":"Mcmahon, Dino","last_name":"Mcmahon","first_name":"Dino"},{"last_name":"Natsopoulou","first_name":"Myrsini","full_name":"Natsopoulou, Myrsini"},{"first_name":"Vincent","last_name":"Doublet","full_name":"Doublet, Vincent"},{"orcid":"0000-0002-3712-925X","last_name":"Fürst","first_name":"Matthias","id":"393B1196-F248-11E8-B48F-1D18A9856A87","full_name":"Fürst, Matthias"},{"last_name":"Weging","first_name":"Silvio","full_name":"Weging, Silvio"},{"full_name":"Brown, Mark","last_name":"Brown","first_name":"Mark"},{"last_name":"Gogol Döring","first_name":"Andreas","full_name":"Gogol Döring, Andreas"},{"first_name":"Robert","last_name":"Paxton","full_name":"Paxton, Robert"}],"date_published":"2016-05-06T00:00:00Z","user_id":"6785fbc1-c503-11eb-8a32-93094b40e1cf","month":"05","_id":"9704","type":"research_data_reference","citation":{"mla":"Mcmahon, Dino, et al. <i>Data from: Elevated Virulence of an Emerging Viral Genotype as a Driver of Honeybee Loss</i>. Dryad, 2016, doi:<a href=\"https://doi.org/10.5061/dryad.cq7t1\">10.5061/dryad.cq7t1</a>.","ieee":"D. Mcmahon <i>et al.</i>, “Data from: Elevated virulence of an emerging viral genotype as a driver of honeybee loss.” Dryad, 2016.","ama":"Mcmahon D, Natsopoulou M, Doublet V, et al. Data from: Elevated virulence of an emerging viral genotype as a driver of honeybee loss. 2016. doi:<a href=\"https://doi.org/10.5061/dryad.cq7t1\">10.5061/dryad.cq7t1</a>","chicago":"Mcmahon, Dino, Myrsini Natsopoulou, Vincent Doublet, Matthias Fürst, Silvio Weging, Mark Brown, Andreas Gogol Döring, and Robert Paxton. “Data from: Elevated Virulence of an Emerging Viral Genotype as a Driver of Honeybee Loss.” Dryad, 2016. <a href=\"https://doi.org/10.5061/dryad.cq7t1\">https://doi.org/10.5061/dryad.cq7t1</a>.","ista":"Mcmahon D, Natsopoulou M, Doublet V, Fürst M, Weging S, Brown M, Gogol Döring A, Paxton R. 2016. Data from: Elevated virulence of an emerging viral genotype as a driver of honeybee loss, Dryad, <a href=\"https://doi.org/10.5061/dryad.cq7t1\">10.5061/dryad.cq7t1</a>.","short":"D. Mcmahon, M. Natsopoulou, V. Doublet, M. Fürst, S. Weging, M. Brown, A. Gogol Döring, R. Paxton, (2016).","apa":"Mcmahon, D., Natsopoulou, M., Doublet, V., Fürst, M., Weging, S., Brown, M., … Paxton, R. (2016). Data from: Elevated virulence of an emerging viral genotype as a driver of honeybee loss. Dryad. <a href=\"https://doi.org/10.5061/dryad.cq7t1\">https://doi.org/10.5061/dryad.cq7t1</a>"},"date_updated":"2023-02-21T16:54:31Z","abstract":[{"lang":"eng","text":"Emerging infectious diseases (EIDs) have contributed significantly to the current biodiversity crisis, leading to widespread epidemics and population loss. Owing to genetic variation in pathogen virulence, a complete understanding of species decline requires the accurate identification and characterization of EIDs. We explore this issue in the Western honeybee, where increasing mortality of populations in the Northern Hemisphere has caused major concern. Specifically, we investigate the importance of genetic identity of the main suspect in mortality, deformed wing virus (DWV), in driving honeybee loss. Using laboratory experiments and a systematic field survey, we demonstrate that an emerging DWV genotype (DWV-B) is more virulent than the established DWV genotype (DWV-A) and is widespread in the landscape. Furthermore, we show in a simple model that colonies infected with DWV-B collapse sooner than colonies infected with DWV-A. We also identify potential for rapid DWV evolution by revealing extensive genome-wide recombination in vivo. The emergence of DWV-B in naive honeybee populations, including via recombination with DWV-A, could be of significant ecological and economic importance. Our findings emphasize that knowledge of pathogen genetic identity and diversity is critical to understanding drivers of species decline."}]},{"related_material":{"record":[{"status":"public","id":"1855","relation":"used_in_publication"}]},"author":[{"full_name":"Mcmahon, Dino","first_name":"Dino","last_name":"Mcmahon"},{"full_name":"Fürst, Matthias","first_name":"Matthias","orcid":"0000-0002-3712-925X","last_name":"Fürst","id":"393B1196-F248-11E8-B48F-1D18A9856A87"},{"first_name":"Jesicca","last_name":"Caspar","full_name":"Caspar, Jesicca"},{"first_name":"Panagiotis","last_name":"Theodorou","full_name":"Theodorou, Panagiotis"},{"last_name":"Brown","first_name":"Mark","full_name":"Brown, Mark"},{"full_name":"Paxton, Robert","last_name":"Paxton","first_name":"Robert"}],"doi":"10.5061/dryad.4b565","oa_version":"Published Version","_id":"9720","abstract":[{"text":"Summary: Declining populations of bee pollinators are a cause of concern, with major repercussions for biodiversity loss and food security. RNA viruses associated with honeybees represent a potential threat to other insect pollinators, but the extent of this threat is poorly understood. This study aims to attain a detailed understanding of the current and ongoing risk of emerging infectious disease (EID) transmission between managed and wild pollinator species across a wide range of RNA viruses. Within a structured large-scale national survey across 26 independent sites, we quantify the prevalence and pathogen loads of multiple RNA viruses in co-occurring managed honeybee (Apis mellifera) and wild bumblebee (Bombus spp.) populations. We then construct models that compare virus prevalence between wild and managed pollinators. Multiple RNA viruses associated with honeybees are widespread in sympatric wild bumblebee populations. Virus prevalence in honeybees is a significant predictor of virus prevalence in bumblebees, but we remain cautious in speculating over the principle direction of pathogen transmission. We demonstrate species-specific differences in prevalence, indicating significant variation in disease susceptibility or tolerance. Pathogen loads within individual bumblebees may be high and in the case of at least one RNA virus, prevalence is higher in wild bumblebees than in managed honeybee populations. Our findings indicate widespread transmission of RNA viruses between managed and wild bee pollinators, pointing to an interconnected network of potential disease pressures within and among pollinator species. In the context of the biodiversity crisis, our study emphasizes the importance of targeting a wide range of pathogens and defining host associations when considering potential drivers of population decline.","lang":"eng"}],"date_updated":"2023-02-23T10:17:25Z","citation":{"apa":"Mcmahon, D., Fürst, M., Caspar, J., Theodorou, P., Brown, M., &#38; Paxton, R. (2016). Data from: A sting in the spit: widespread cross-infection of multiple RNA viruses across wild and managed bees. Dryad. <a href=\"https://doi.org/10.5061/dryad.4b565\">https://doi.org/10.5061/dryad.4b565</a>","short":"D. Mcmahon, M. Fürst, J. Caspar, P. Theodorou, M. Brown, R. Paxton, (2016).","ista":"Mcmahon D, Fürst M, Caspar J, Theodorou P, Brown M, Paxton R. 2016. Data from: A sting in the spit: widespread cross-infection of multiple RNA viruses across wild and managed bees, Dryad, <a href=\"https://doi.org/10.5061/dryad.4b565\">10.5061/dryad.4b565</a>.","chicago":"Mcmahon, Dino, Matthias Fürst, Jesicca Caspar, Panagiotis Theodorou, Mark Brown, and Robert Paxton. “Data from: A Sting in the Spit: Widespread Cross-Infection of Multiple RNA Viruses across Wild and Managed Bees.” Dryad, 2016. <a href=\"https://doi.org/10.5061/dryad.4b565\">https://doi.org/10.5061/dryad.4b565</a>.","ama":"Mcmahon D, Fürst M, Caspar J, Theodorou P, Brown M, Paxton R. Data from: A sting in the spit: widespread cross-infection of multiple RNA viruses across wild and managed bees. 2016. doi:<a href=\"https://doi.org/10.5061/dryad.4b565\">10.5061/dryad.4b565</a>","ieee":"D. Mcmahon, M. Fürst, J. Caspar, P. Theodorou, M. Brown, and R. Paxton, “Data from: A sting in the spit: widespread cross-infection of multiple RNA viruses across wild and managed bees.” Dryad, 2016.","mla":"Mcmahon, Dino, et al. <i>Data from: A Sting in the Spit: Widespread Cross-Infection of Multiple RNA Viruses across Wild and Managed Bees</i>. Dryad, 2016, doi:<a href=\"https://doi.org/10.5061/dryad.4b565\">10.5061/dryad.4b565</a>."},"type":"research_data_reference","month":"01","date_published":"2016-01-22T00:00:00Z","user_id":"6785fbc1-c503-11eb-8a32-93094b40e1cf","publisher":"Dryad","article_processing_charge":"No","year":"2016","status":"public","date_created":"2021-07-26T09:14:19Z","department":[{"_id":"SyCr"}],"day":"22","oa":1,"main_file_link":[{"open_access":"1","url":"https://doi.org/10.5061/dryad.4b565"}],"title":"Data from: A sting in the spit: widespread cross-infection of multiple RNA viruses across wild and managed bees"},{"quality_controlled":"1","oa":1,"issue":"3","day":"03","department":[{"_id":"SyCr"}],"status":"public","date_created":"2018-12-11T11:54:23Z","file":[{"creator":"system","date_updated":"2020-07-14T12:45:19Z","content_type":"application/pdf","file_size":1823045,"file_id":"5350","relation":"main_file","access_level":"open_access","file_name":"IST-2016-460-v1+1_McMahon_et_al-2015-Journal_of_Animal_Ecology.pdf","date_created":"2018-12-12T10:18:29Z","checksum":"542a0b9b07e78050a81b35f26f0b82da"}],"page":"615 - 624","publisher":"Wiley","user_id":"6785fbc1-c503-11eb-8a32-93094b40e1cf","publication_status":"published","abstract":[{"text":"Summary: Declining populations of bee pollinators are a cause of concern, with major repercussions for biodiversity loss and food security. RNA viruses associated with honeybees represent a potential threat to other insect pollinators, but the extent of this threat is poorly understood. This study aims to attain a detailed understanding of the current and ongoing risk of emerging infectious disease (EID) transmission between managed and wild pollinator species across a wide range of RNA viruses. Within a structured large-scale national survey across 26 independent sites, we quantify the prevalence and pathogen loads of multiple RNA viruses in co-occurring managed honeybee (Apis mellifera) and wild bumblebee (Bombus spp.) populations. We then construct models that compare virus prevalence between wild and managed pollinators. Multiple RNA viruses associated with honeybees are widespread in sympatric wild bumblebee populations. Virus prevalence in honeybees is a significant predictor of virus prevalence in bumblebees, but we remain cautious in speculating over the principle direction of pathogen transmission. We demonstrate species-specific differences in prevalence, indicating significant variation in disease susceptibility or tolerance. Pathogen loads within individual bumblebees may be high and in the case of at least one RNA virus, prevalence is higher in wild bumblebees than in managed honeybee populations. Our findings indicate widespread transmission of RNA viruses between managed and wild bee pollinators, pointing to an interconnected network of potential disease pressures within and among pollinator species. In the context of the biodiversity crisis, our study emphasizes the importance of targeting a wide range of pathogens and defining host associations when considering potential drivers of population decline.","lang":"eng"}],"_id":"1855","volume":84,"author":[{"full_name":"Mcmahon, Dino","last_name":"Mcmahon","first_name":"Dino"},{"full_name":"Fürst, Matthias","id":"393B1196-F248-11E8-B48F-1D18A9856A87","first_name":"Matthias","last_name":"Fürst","orcid":"0000-0002-3712-925X"},{"full_name":"Caspar, Jesicca","last_name":"Caspar","first_name":"Jesicca"},{"last_name":"Theodorou","first_name":"Panagiotis","full_name":"Theodorou, Panagiotis"},{"full_name":"Brown, Mark","last_name":"Brown","first_name":"Mark"},{"full_name":"Paxton, Robert","last_name":"Paxton","first_name":"Robert"}],"external_id":{"pmid":["25646973"]},"intvolume":"        84","title":"A sting in the spit: Widespread cross-infection of multiple RNA viruses across wild and managed bees","pubrep_id":"460","acknowledgement":"We thank J.R. de Miranda, L. De Smet and D. de Graaf for supplying qRT-PCR and MLPA positive controls, respectively, in the form of plasmids. This work was supported by the Insect Pollinators Initiative (IPI grants BB/1000100/1 and BB/I000151/1). The IPI is funded jointly by the Biotechnology and Biological Sciences Research Council, the Department for Environment, Food and Rural Affairs, the Natural Environment Research Council, The Scottish Government and The Wellcome Trust, under the Living with Environmental Change Partnership.","language":[{"iso":"eng"}],"year":"2015","article_processing_charge":"No","publication":"Journal of Animal Ecology","date_published":"2015-03-03T00:00:00Z","month":"03","ddc":["570"],"tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"scopus_import":"1","citation":{"ama":"Mcmahon D, Fürst M, Caspar J, Theodorou P, Brown M, Paxton R. A sting in the spit: Widespread cross-infection of multiple RNA viruses across wild and managed bees. <i>Journal of Animal Ecology</i>. 2015;84(3):615-624. doi:<a href=\"https://doi.org/10.1111/1365-2656.12345\">10.1111/1365-2656.12345</a>","mla":"Mcmahon, Dino, et al. “A Sting in the Spit: Widespread Cross-Infection of Multiple RNA Viruses across Wild and Managed Bees.” <i>Journal of Animal Ecology</i>, vol. 84, no. 3, Wiley, 2015, pp. 615–24, doi:<a href=\"https://doi.org/10.1111/1365-2656.12345\">10.1111/1365-2656.12345</a>.","ieee":"D. Mcmahon, M. Fürst, J. Caspar, P. Theodorou, M. Brown, and R. Paxton, “A sting in the spit: Widespread cross-infection of multiple RNA viruses across wild and managed bees,” <i>Journal of Animal Ecology</i>, vol. 84, no. 3. Wiley, pp. 615–624, 2015.","short":"D. Mcmahon, M. Fürst, J. Caspar, P. Theodorou, M. Brown, R. Paxton, Journal of Animal Ecology 84 (2015) 615–624.","apa":"Mcmahon, D., Fürst, M., Caspar, J., Theodorou, P., Brown, M., &#38; Paxton, R. (2015). A sting in the spit: Widespread cross-infection of multiple RNA viruses across wild and managed bees. <i>Journal of Animal Ecology</i>. Wiley. <a href=\"https://doi.org/10.1111/1365-2656.12345\">https://doi.org/10.1111/1365-2656.12345</a>","chicago":"Mcmahon, Dino, Matthias Fürst, Jesicca Caspar, Panagiotis Theodorou, Mark Brown, and Robert Paxton. “A Sting in the Spit: Widespread Cross-Infection of Multiple RNA Viruses across Wild and Managed Bees.” <i>Journal of Animal Ecology</i>. Wiley, 2015. <a href=\"https://doi.org/10.1111/1365-2656.12345\">https://doi.org/10.1111/1365-2656.12345</a>.","ista":"Mcmahon D, Fürst M, Caspar J, Theodorou P, Brown M, Paxton R. 2015. A sting in the spit: Widespread cross-infection of multiple RNA viruses across wild and managed bees. Journal of Animal Ecology. 84(3), 615–624."},"date_updated":"2023-02-23T14:06:09Z","has_accepted_license":"1","pmid":1,"type":"journal_article","oa_version":"Published Version","file_date_updated":"2020-07-14T12:45:19Z","related_material":{"record":[{"relation":"research_data","id":"9720","status":"public"}]},"article_type":"original","publist_id":"5245","doi":"10.1111/1365-2656.12345"},{"publist_id":"4726","doi":"10.1038/nature12977","oa_version":"Submitted Version","type":"journal_article","citation":{"ama":"Fürst M, Mcmahon D, Osborne J, Paxton R, Brown M. Disease associations between honeybees and bumblebees as a threat to wild pollinators. <i>Nature</i>. 2014;506(7488):364-366. doi:<a href=\"https://doi.org/10.1038/nature12977\">10.1038/nature12977</a>","mla":"Fürst, Matthias, et al. “Disease Associations between Honeybees and Bumblebees as a Threat to Wild Pollinators.” <i>Nature</i>, vol. 506, no. 7488, Nature Publishing Group, 2014, pp. 364–66, doi:<a href=\"https://doi.org/10.1038/nature12977\">10.1038/nature12977</a>.","ieee":"M. Fürst, D. Mcmahon, J. Osborne, R. Paxton, and M. Brown, “Disease associations between honeybees and bumblebees as a threat to wild pollinators,” <i>Nature</i>, vol. 506, no. 7488. Nature Publishing Group, pp. 364–366, 2014.","short":"M. Fürst, D. Mcmahon, J. Osborne, R. Paxton, M. Brown, Nature 506 (2014) 364–366.","apa":"Fürst, M., Mcmahon, D., Osborne, J., Paxton, R., &#38; Brown, M. (2014). Disease associations between honeybees and bumblebees as a threat to wild pollinators. <i>Nature</i>. Nature Publishing Group. <a href=\"https://doi.org/10.1038/nature12977\">https://doi.org/10.1038/nature12977</a>","chicago":"Fürst, Matthias, Dino Mcmahon, Juliet Osborne, Robert Paxton, and Mark Brown. “Disease Associations between Honeybees and Bumblebees as a Threat to Wild Pollinators.” <i>Nature</i>. Nature Publishing Group, 2014. <a href=\"https://doi.org/10.1038/nature12977\">https://doi.org/10.1038/nature12977</a>.","ista":"Fürst M, Mcmahon D, Osborne J, Paxton R, Brown M. 2014. Disease associations between honeybees and bumblebees as a threat to wild pollinators. Nature. 506(7488), 364–366."},"date_updated":"2021-01-12T06:56:11Z","scopus_import":1,"date_published":"2014-02-20T00:00:00Z","month":"02","publication":"Nature","year":"2014","language":[{"iso":"eng"}],"main_file_link":[{"open_access":"1","url":"http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3985068/"}],"title":"Disease associations between honeybees and bumblebees as a threat to wild pollinators","intvolume":"       506","author":[{"full_name":"Fürst, Matthias","id":"393B1196-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-3712-925X","last_name":"Fürst","first_name":"Matthias"},{"full_name":"Mcmahon, Dino","first_name":"Dino","last_name":"Mcmahon"},{"first_name":"Juliet","last_name":"Osborne","full_name":"Osborne, Juliet"},{"full_name":"Paxton, Robert","first_name":"Robert","last_name":"Paxton"},{"last_name":"Brown","first_name":"Mark","full_name":"Brown, Mark"}],"publication_identifier":{"issn":["00280836"]},"volume":506,"_id":"2235","abstract":[{"text":"Emerging infectious diseases (EIDs) pose a risk to human welfare, both directly and indirectly, by affecting managed livestock and wildlife that provide valuable resources and ecosystem services, such as the pollination of crops. Honeybees (Apis mellifera), the prevailing managed insect crop pollinator, suffer from a range of emerging and exotic high-impact pathogens, and population maintenance requires active management by beekeepers to control them. Wild pollinators such as bumblebees (Bombus spp.) are in global decline, one cause of which may be pathogen spillover from managed pollinators like honeybees or commercial colonies of bumblebees. Here we use a combination of infection experiments and landscape-scale field data to show that honeybee EIDs are indeed widespread infectious agents within the pollinator assemblage. The prevalence of deformed wing virus (DWV) and the exotic parasite Nosema ceranae in honeybees and bumblebees is linked; as honeybees have higher DWV prevalence, and sympatric bumblebees and honeybees are infected by the same DWV strains, Apis is the likely source of at least one major EID in wild pollinators. Lessons learned from vertebrates highlight the need for increased pathogen control in managed bee species to maintain wild pollinators, as declines in native pollinators may be caused by interspecies pathogen transmission originating from managed pollinators.","lang":"eng"}],"publication_status":"published","user_id":"4435EBFC-F248-11E8-B48F-1D18A9856A87","publisher":"Nature Publishing Group","page":"364 - 366","date_created":"2018-12-11T11:56:29Z","status":"public","department":[{"_id":"SyCr"}],"day":"20","oa":1,"issue":"7488","quality_controlled":"1"}]