---
_id: '6022'
abstract:
- lang: eng
  text: The evolution of new species is made easier when traits under divergent ecological
    selection are also mating cues. Such ecological mating cues are now considered
    more common than previously thought, but we still know little about the genetic
    changes underlying their evolution or more generally about the genetic basis for
    assortative mating behaviors. Both tight physical linkage and the existence of
    large-effect preference loci will strengthen genetic associations between behavioral
    and ecological barriers, promoting the evolution of assortative mating. The warning
    patterns of Heliconius melpomene and H. cydno are under disruptive selection due
    to increased predation of nonmimetic hybrids and are used during mate recognition.
    We carried out a genome-wide quantitative trait locus (QTL) analysis of preference
    behaviors between these species and showed that divergent male preference has
    a simple genetic basis. We identify three QTLs that together explain a large proportion
    (approximately 60%) of the difference in preference behavior observed between
    the parental species. One of these QTLs is just 1.2 (0-4.8) centiMorgans (cM)
    from the major color pattern gene optix, and, individually, all three have a large
    effect on the preference phenotype. Genomic divergence between H. cydno and H.
    melpomene is high but broadly heterogenous, and admixture is reduced at the preference-optix
    color pattern locus but not the other preference QTLs. The simple genetic architecture
    we reveal will facilitate the evolution and maintenance of new species despite
    ongoing gene flow by coupling behavioral and ecological aspects of reproductive
    isolation.
article_number: e2005902
article_processing_charge: No
author:
- first_name: Richard M.
  full_name: Merrill, Richard M.
  last_name: Merrill
- first_name: Pasi
  full_name: Rastas, Pasi
  last_name: Rastas
- first_name: Simon H.
  full_name: Martin, Simon H.
  last_name: Martin
- first_name: Maria C
  full_name: Melo Hurtado, Maria C
  id: 386D7308-F248-11E8-B48F-1D18A9856A87
  last_name: Melo Hurtado
- first_name: Sarah
  full_name: Barker, Sarah
  last_name: Barker
- first_name: John
  full_name: Davey, John
  last_name: Davey
- first_name: W. Owen
  full_name: Mcmillan, W. Owen
  last_name: Mcmillan
- first_name: Chris D.
  full_name: Jiggins, Chris D.
  last_name: Jiggins
citation:
  ama: Merrill RM, Rastas P, Martin SH, et al. Genetic dissection of assortative mating
    behavior. <i>PLoS Biology</i>. 2019;17(2). doi:<a href="https://doi.org/10.1371/journal.pbio.2005902">10.1371/journal.pbio.2005902</a>
  apa: Merrill, R. M., Rastas, P., Martin, S. H., Melo Hurtado, M. C., Barker, S.,
    Davey, J., … Jiggins, C. D. (2019). Genetic dissection of assortative mating behavior.
    <i>PLoS Biology</i>. Public Library of Science. <a href="https://doi.org/10.1371/journal.pbio.2005902">https://doi.org/10.1371/journal.pbio.2005902</a>
  chicago: Merrill, Richard M., Pasi Rastas, Simon H. Martin, Maria C Melo Hurtado,
    Sarah Barker, John Davey, W. Owen Mcmillan, and Chris D. Jiggins. “Genetic Dissection
    of Assortative Mating Behavior.” <i>PLoS Biology</i>. Public Library of Science,
    2019. <a href="https://doi.org/10.1371/journal.pbio.2005902">https://doi.org/10.1371/journal.pbio.2005902</a>.
  ieee: R. M. Merrill <i>et al.</i>, “Genetic dissection of assortative mating behavior,”
    <i>PLoS Biology</i>, vol. 17, no. 2. Public Library of Science, 2019.
  ista: Merrill RM, Rastas P, Martin SH, Melo Hurtado MC, Barker S, Davey J, Mcmillan
    WO, Jiggins CD. 2019. Genetic dissection of assortative mating behavior. PLoS
    Biology. 17(2), e2005902.
  mla: Merrill, Richard M., et al. “Genetic Dissection of Assortative Mating Behavior.”
    <i>PLoS Biology</i>, vol. 17, no. 2, e2005902, Public Library of Science, 2019,
    doi:<a href="https://doi.org/10.1371/journal.pbio.2005902">10.1371/journal.pbio.2005902</a>.
  short: R.M. Merrill, P. Rastas, S.H. Martin, M.C. Melo Hurtado, S. Barker, J. Davey,
    W.O. Mcmillan, C.D. Jiggins, PLoS Biology 17 (2019).
date_created: 2019-02-17T22:59:21Z
date_published: 2019-02-07T00:00:00Z
date_updated: 2023-08-24T14:46:23Z
day: '07'
ddc:
- '570'
department:
- _id: NiBa
doi: 10.1371/journal.pbio.2005902
external_id:
  isi:
  - '000460317100001'
file:
- access_level: open_access
  checksum: 5f34001617ee729314ca520c049b1112
  content_type: application/pdf
  creator: dernst
  date_created: 2019-02-18T14:57:24Z
  date_updated: 2020-07-14T12:47:17Z
  file_id: '6036'
  file_name: 2019_PLOS_Merrill.pdf
  file_size: 2005949
  relation: main_file
file_date_updated: 2020-07-14T12:47:17Z
has_accepted_license: '1'
intvolume: '        17'
isi: 1
issue: '2'
language:
- iso: eng
license: https://creativecommons.org/publicdomain/zero/1.0/
month: '02'
oa: 1
oa_version: Published Version
publication: PLoS Biology
publication_status: published
publisher: Public Library of Science
quality_controlled: '1'
related_material:
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  - id: '9801'
    relation: research_data
    status: public
scopus_import: '1'
status: public
title: Genetic dissection of assortative mating behavior
tmp:
  image: /images/cc_0.png
  legal_code_url: https://creativecommons.org/publicdomain/zero/1.0/legalcode
  name: Creative Commons Public Domain Dedication (CC0 1.0)
  short: CC0 (1.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 17
year: '2019'
...
---
_id: '9801'
article_processing_charge: No
author:
- first_name: Richard M.
  full_name: Merrill, Richard M.
  last_name: Merrill
- first_name: Pasi
  full_name: Rastas, Pasi
  last_name: Rastas
- first_name: Simon H.
  full_name: Martin, Simon H.
  last_name: Martin
- first_name: Maria C
  full_name: Melo Hurtado, Maria C
  id: 386D7308-F248-11E8-B48F-1D18A9856A87
  last_name: Melo Hurtado
- first_name: Sarah
  full_name: Barker, Sarah
  last_name: Barker
- first_name: John
  full_name: Davey, John
  last_name: Davey
- first_name: W. Owen
  full_name: Mcmillan, W. Owen
  last_name: Mcmillan
- first_name: Chris D.
  full_name: Jiggins, Chris D.
  last_name: Jiggins
citation:
  ama: Merrill RM, Rastas P, Martin SH, et al. Raw behavioral data. 2019. doi:<a href="https://doi.org/10.1371/journal.pbio.2005902.s006">10.1371/journal.pbio.2005902.s006</a>
  apa: Merrill, R. M., Rastas, P., Martin, S. H., Melo Hurtado, M. C., Barker, S.,
    Davey, J., … Jiggins, C. D. (2019). Raw behavioral data. Public Library of Science.
    <a href="https://doi.org/10.1371/journal.pbio.2005902.s006">https://doi.org/10.1371/journal.pbio.2005902.s006</a>
  chicago: Merrill, Richard M., Pasi Rastas, Simon H. Martin, Maria C Melo Hurtado,
    Sarah Barker, John Davey, W. Owen Mcmillan, and Chris D. Jiggins. “Raw Behavioral
    Data.” Public Library of Science, 2019. <a href="https://doi.org/10.1371/journal.pbio.2005902.s006">https://doi.org/10.1371/journal.pbio.2005902.s006</a>.
  ieee: R. M. Merrill <i>et al.</i>, “Raw behavioral data.” Public Library of Science,
    2019.
  ista: Merrill RM, Rastas P, Martin SH, Melo Hurtado MC, Barker S, Davey J, Mcmillan
    WO, Jiggins CD. 2019. Raw behavioral data, Public Library of Science, <a href="https://doi.org/10.1371/journal.pbio.2005902.s006">10.1371/journal.pbio.2005902.s006</a>.
  mla: Merrill, Richard M., et al. <i>Raw Behavioral Data</i>. Public Library of Science,
    2019, doi:<a href="https://doi.org/10.1371/journal.pbio.2005902.s006">10.1371/journal.pbio.2005902.s006</a>.
  short: R.M. Merrill, P. Rastas, S.H. Martin, M.C. Melo Hurtado, S. Barker, J. Davey,
    W.O. Mcmillan, C.D. Jiggins, (2019).
date_created: 2021-08-06T11:34:56Z
date_published: 2019-02-07T00:00:00Z
date_updated: 2023-08-24T14:46:23Z
day: '07'
department:
- _id: NiBa
doi: 10.1371/journal.pbio.2005902.s006
month: '02'
oa_version: Published Version
publisher: Public Library of Science
related_material:
  record:
  - id: '6022'
    relation: used_in_publication
    status: public
status: public
title: Raw behavioral data
type: research_data_reference
user_id: 6785fbc1-c503-11eb-8a32-93094b40e1cf
year: '2019'
...