---
_id: '5828'
abstract:
- lang: eng
  text: Hippocampus is needed for both spatial working and reference memories. Here,
    using a radial eight-arm maze, we examined how the combined demand on these memories
    influenced CA1 place cell assemblies while reference memories were partially updated.
    This was contrasted with control tasks requiring only working memory or the update
    of reference memory. Reference memory update led to the reward-directed place
    field shifts at newly rewarded arms and to the gradual strengthening of firing
    in passes between newly rewarded arms but not between those passes that included
    a familiar-rewarded arm. At the maze center, transient network synchronization
    periods preferentially replayed trajectories of the next chosen arm in reference
    memory tasks but the previously visited arm in the working memory task. Hence,
    reference memory demand was uniquely associated with a gradual, goal novelty-related
    reorganization of place cell assemblies and with trajectory replay that reflected
    the animal's decision of which arm to visit next.
article_processing_charge: No
article_type: original
author:
- first_name: Haibing
  full_name: Xu, Haibing
  id: 310349D0-F248-11E8-B48F-1D18A9856A87
  last_name: Xu
- first_name: Peter
  full_name: Baracskay, Peter
  id: 361CC00E-F248-11E8-B48F-1D18A9856A87
  last_name: Baracskay
- first_name: Joseph
  full_name: O'Neill, Joseph
  id: 426376DC-F248-11E8-B48F-1D18A9856A87
  last_name: O'Neill
- first_name: Jozsef L
  full_name: Csicsvari, Jozsef L
  id: 3FA14672-F248-11E8-B48F-1D18A9856A87
  last_name: Csicsvari
  orcid: 0000-0002-5193-4036
citation:
  ama: Xu H, Baracskay P, O’Neill J, Csicsvari JL. Assembly responses of hippocampal
    CA1 place cells predict learned behavior in goal-directed spatial tasks on the
    radial eight-arm maze. <i>Neuron</i>. 2019;101(1):119-132.e4. doi:<a href="https://doi.org/10.1016/j.neuron.2018.11.015">10.1016/j.neuron.2018.11.015</a>
  apa: Xu, H., Baracskay, P., O’Neill, J., &#38; Csicsvari, J. L. (2019). Assembly
    responses of hippocampal CA1 place cells predict learned behavior in goal-directed
    spatial tasks on the radial eight-arm maze. <i>Neuron</i>. Elsevier. <a href="https://doi.org/10.1016/j.neuron.2018.11.015">https://doi.org/10.1016/j.neuron.2018.11.015</a>
  chicago: Xu, Haibing, Peter Baracskay, Joseph O’Neill, and Jozsef L Csicsvari. “Assembly
    Responses of Hippocampal CA1 Place Cells Predict Learned Behavior in Goal-Directed
    Spatial Tasks on the Radial Eight-Arm Maze.” <i>Neuron</i>. Elsevier, 2019. <a
    href="https://doi.org/10.1016/j.neuron.2018.11.015">https://doi.org/10.1016/j.neuron.2018.11.015</a>.
  ieee: H. Xu, P. Baracskay, J. O’Neill, and J. L. Csicsvari, “Assembly responses
    of hippocampal CA1 place cells predict learned behavior in goal-directed spatial
    tasks on the radial eight-arm maze,” <i>Neuron</i>, vol. 101, no. 1. Elsevier,
    p. 119–132.e4, 2019.
  ista: Xu H, Baracskay P, O’Neill J, Csicsvari JL. 2019. Assembly responses of hippocampal
    CA1 place cells predict learned behavior in goal-directed spatial tasks on the
    radial eight-arm maze. Neuron. 101(1), 119–132.e4.
  mla: Xu, Haibing, et al. “Assembly Responses of Hippocampal CA1 Place Cells Predict
    Learned Behavior in Goal-Directed Spatial Tasks on the Radial Eight-Arm Maze.”
    <i>Neuron</i>, vol. 101, no. 1, Elsevier, 2019, p. 119–132.e4, doi:<a href="https://doi.org/10.1016/j.neuron.2018.11.015">10.1016/j.neuron.2018.11.015</a>.
  short: H. Xu, P. Baracskay, J. O’Neill, J.L. Csicsvari, Neuron 101 (2019) 119–132.e4.
date_created: 2019-01-13T22:59:10Z
date_published: 2019-01-02T00:00:00Z
date_updated: 2023-09-07T12:06:37Z
day: '02'
department:
- _id: JoCs
doi: 10.1016/j.neuron.2018.11.015
ec_funded: 1
external_id:
  isi:
  - '000454791500014'
intvolume: '       101'
isi: 1
issue: '1'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://www.doi.org/10.1016/j.neuron.2018.11.015
month: '01'
oa: 1
oa_version: Published Version
page: 119-132.e4
project:
- _id: 257A4776-B435-11E9-9278-68D0E5697425
  call_identifier: FP7
  grant_number: '281511'
  name: Memory-related information processing in neuronal circuits of the hippocampus
    and entorhinal cortex
publication: Neuron
publication_identifier:
  issn:
  - '10974199'
publication_status: published
publisher: Elsevier
quality_controlled: '1'
related_material:
  link:
  - description: News on IST Homepage
    relation: press_release
    url: https://ist.ac.at/en/news/reading-rats-minds/
  record:
  - id: '837'
    relation: dissertation_contains
    status: public
scopus_import: '1'
status: public
title: Assembly responses of hippocampal CA1 place cells predict learned behavior
  in goal-directed spatial tasks on the radial eight-arm maze
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 101
year: '2019'
...
---
_id: '6338'
abstract:
- lang: eng
  text: Hippocampal activity patterns representing movement trajectories are reactivated
    in immobility and sleep periods, a process associated with memory recall, consolidation,
    and decision making. It is thought that only fixed, behaviorally relevant patterns
    can be reactivated, which are stored across hippocampal synaptic connections.
    To test whether some generalized rules govern reactivation, we examined trajectory
    reactivation following non-stereotypical exploration of familiar open-field environments.
    We found that random trajectories of varying lengths and timescales were reactivated,
    resembling that of Brownian motion of particles. The animals’ behavioral trajectory
    did not follow Brownian diffusion demonstrating that the exact behavioral experience
    is not reactivated. Therefore, hippocampal circuits are able to generate random
    trajectories of any recently active map by following diffusion dynamics. This
    ability of hippocampal circuits to generate representations of all behavioral
    outcome combinations, experienced or not, may underlie a wide variety of hippocampal-dependent
    cognitive functions such as learning, generalization, and planning.
article_processing_charge: No
article_type: original
author:
- first_name: Federico
  full_name: Stella, Federico
  id: 39AF1E74-F248-11E8-B48F-1D18A9856A87
  last_name: Stella
  orcid: 0000-0001-9439-3148
- first_name: Peter
  full_name: Baracskay, Peter
  id: 361CC00E-F248-11E8-B48F-1D18A9856A87
  last_name: Baracskay
- first_name: Joseph
  full_name: O'Neill, Joseph
  id: 426376DC-F248-11E8-B48F-1D18A9856A87
  last_name: O'Neill
- first_name: Jozsef L
  full_name: Csicsvari, Jozsef L
  id: 3FA14672-F248-11E8-B48F-1D18A9856A87
  last_name: Csicsvari
  orcid: 0000-0002-5193-4036
citation:
  ama: Stella F, Baracskay P, O’Neill J, Csicsvari JL. Hippocampal reactivation of
    random trajectories resembling Brownian diffusion. <i>Neuron</i>. 2019;102:450-461.
    doi:<a href="https://doi.org/10.1016/j.neuron.2019.01.052">10.1016/j.neuron.2019.01.052</a>
  apa: Stella, F., Baracskay, P., O’Neill, J., &#38; Csicsvari, J. L. (2019). Hippocampal
    reactivation of random trajectories resembling Brownian diffusion. <i>Neuron</i>.
    Elsevier. <a href="https://doi.org/10.1016/j.neuron.2019.01.052">https://doi.org/10.1016/j.neuron.2019.01.052</a>
  chicago: Stella, Federico, Peter Baracskay, Joseph O’Neill, and Jozsef L Csicsvari.
    “Hippocampal Reactivation of Random Trajectories Resembling Brownian Diffusion.”
    <i>Neuron</i>. Elsevier, 2019. <a href="https://doi.org/10.1016/j.neuron.2019.01.052">https://doi.org/10.1016/j.neuron.2019.01.052</a>.
  ieee: F. Stella, P. Baracskay, J. O’Neill, and J. L. Csicsvari, “Hippocampal reactivation
    of random trajectories resembling Brownian diffusion,” <i>Neuron</i>, vol. 102.
    Elsevier, pp. 450–461, 2019.
  ista: Stella F, Baracskay P, O’Neill J, Csicsvari JL. 2019. Hippocampal reactivation
    of random trajectories resembling Brownian diffusion. Neuron. 102, 450–461.
  mla: Stella, Federico, et al. “Hippocampal Reactivation of Random Trajectories Resembling
    Brownian Diffusion.” <i>Neuron</i>, vol. 102, Elsevier, 2019, pp. 450–61, doi:<a
    href="https://doi.org/10.1016/j.neuron.2019.01.052">10.1016/j.neuron.2019.01.052</a>.
  short: F. Stella, P. Baracskay, J. O’Neill, J.L. Csicsvari, Neuron 102 (2019) 450–461.
date_created: 2019-04-17T08:28:59Z
date_published: 2019-04-17T00:00:00Z
date_updated: 2023-08-25T10:13:07Z
day: '17'
department:
- _id: JoCs
doi: 10.1016/j.neuron.2019.01.052
ec_funded: 1
external_id:
  isi:
  - '000465169700017'
  pmid:
  - '30819547'
intvolume: '       102'
isi: 1
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://doi.org/10.1016/j.neuron.2019.01.052
month: '04'
oa: 1
oa_version: Published Version
page: 450-461
pmid: 1
project:
- _id: 257A4776-B435-11E9-9278-68D0E5697425
  call_identifier: FP7
  grant_number: '281511'
  name: Memory-related information processing in neuronal circuits of the hippocampus
    and entorhinal cortex
- _id: 2654F984-B435-11E9-9278-68D0E5697425
  call_identifier: FWF
  grant_number: I03713
  name: Interneuro Plasticity During Spatial Learning
publication: Neuron
publication_status: published
publisher: Elsevier
quality_controlled: '1'
related_material:
  link:
  - description: News on IST Homepage
    relation: press_release
    url: https://ist.ac.at/en/news/memories-of-movement-are-replayed-randomly-during-sleep/
scopus_import: '1'
status: public
title: Hippocampal reactivation of random trajectories resembling Brownian diffusion
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 102
year: '2019'
...