---
_id: '13230'
abstract:
- lang: eng
  text: 'To interpret the sensory environment, the brain combines ambiguous sensory
    measurements with knowledge that reflects context-specific prior experience. But
    environmental contexts can change abruptly and unpredictably, resulting in uncertainty
    about the current context. Here we address two questions: how should context-specific
    prior knowledge optimally guide the interpretation of sensory stimuli in changing
    environments, and do human decision-making strategies resemble this optimum? We
    probe these questions with a task in which subjects report the orientation of
    ambiguous visual stimuli that were drawn from three dynamically switching distributions,
    representing different environmental contexts. We derive predictions for an ideal
    Bayesian observer that leverages knowledge about the statistical structure of
    the task to maximize decision accuracy, including knowledge about the dynamics
    of the environment. We show that its decisions are biased by the dynamically changing
    task context. The magnitude of this decision bias depends on the observer’s continually
    evolving belief about the current context. The model therefore not only predicts
    that decision bias will grow as the context is indicated more reliably, but also
    as the stability of the environment increases, and as the number of trials since
    the last context switch grows. Analysis of human choice data validates all three
    predictions, suggesting that the brain leverages knowledge of the statistical
    structure of environmental change when interpreting ambiguous sensory signals.'
acknowledgement: The authors thank Corey Ziemba and Zoe Boundy-Singer for valuable
  discussion and feedback.
article_number: e1011104
article_processing_charge: No
article_type: original
author:
- first_name: Julie A.
  full_name: Charlton, Julie A.
  last_name: Charlton
- first_name: Wiktor F
  full_name: Mlynarski, Wiktor F
  id: 358A453A-F248-11E8-B48F-1D18A9856A87
  last_name: Mlynarski
- first_name: Yoon H.
  full_name: Bai, Yoon H.
  last_name: Bai
- first_name: Ann M.
  full_name: Hermundstad, Ann M.
  last_name: Hermundstad
- first_name: Robbe L.T.
  full_name: Goris, Robbe L.T.
  last_name: Goris
citation:
  ama: Charlton JA, Mlynarski WF, Bai YH, Hermundstad AM, Goris RLT. Environmental
    dynamics shape perceptual decision bias. <i>PLoS Computational Biology</i>. 2023;19(6).
    doi:<a href="https://doi.org/10.1371/journal.pcbi.1011104">10.1371/journal.pcbi.1011104</a>
  apa: Charlton, J. A., Mlynarski, W. F., Bai, Y. H., Hermundstad, A. M., &#38; Goris,
    R. L. T. (2023). Environmental dynamics shape perceptual decision bias. <i>PLoS
    Computational Biology</i>. Public Library of Science. <a href="https://doi.org/10.1371/journal.pcbi.1011104">https://doi.org/10.1371/journal.pcbi.1011104</a>
  chicago: Charlton, Julie A., Wiktor F Mlynarski, Yoon H. Bai, Ann M. Hermundstad,
    and Robbe L.T. Goris. “Environmental Dynamics Shape Perceptual Decision Bias.”
    <i>PLoS Computational Biology</i>. Public Library of Science, 2023. <a href="https://doi.org/10.1371/journal.pcbi.1011104">https://doi.org/10.1371/journal.pcbi.1011104</a>.
  ieee: J. A. Charlton, W. F. Mlynarski, Y. H. Bai, A. M. Hermundstad, and R. L. T.
    Goris, “Environmental dynamics shape perceptual decision bias,” <i>PLoS Computational
    Biology</i>, vol. 19, no. 6. Public Library of Science, 2023.
  ista: Charlton JA, Mlynarski WF, Bai YH, Hermundstad AM, Goris RLT. 2023. Environmental
    dynamics shape perceptual decision bias. PLoS Computational Biology. 19(6), e1011104.
  mla: Charlton, Julie A., et al. “Environmental Dynamics Shape Perceptual Decision
    Bias.” <i>PLoS Computational Biology</i>, vol. 19, no. 6, e1011104, Public Library
    of Science, 2023, doi:<a href="https://doi.org/10.1371/journal.pcbi.1011104">10.1371/journal.pcbi.1011104</a>.
  short: J.A. Charlton, W.F. Mlynarski, Y.H. Bai, A.M. Hermundstad, R.L.T. Goris,
    PLoS Computational Biology 19 (2023).
date_created: 2023-07-16T22:01:09Z
date_published: 2023-06-08T00:00:00Z
date_updated: 2023-08-02T06:33:50Z
day: '08'
ddc:
- '570'
department:
- _id: MaJö
doi: 10.1371/journal.pcbi.1011104
external_id:
  isi:
  - '001003410200003'
  pmid:
  - '37289753'
file:
- access_level: open_access
  checksum: 800761fa2c647fabd6ad034589bc526e
  content_type: application/pdf
  creator: dernst
  date_created: 2023-07-18T08:07:59Z
  date_updated: 2023-07-18T08:07:59Z
  file_id: '13247'
  file_name: 2023_PloSCompBio_Charlton.pdf
  file_size: 2281868
  relation: main_file
  success: 1
file_date_updated: 2023-07-18T08:07:59Z
has_accepted_license: '1'
intvolume: '        19'
isi: 1
issue: '6'
language:
- iso: eng
license: https://creativecommons.org/licenses/by/4.0/
month: '06'
oa: 1
oa_version: Published Version
pmid: 1
publication: PLoS Computational Biology
publication_identifier:
  eissn:
  - 1553-7358
publication_status: published
publisher: Public Library of Science
quality_controlled: '1'
scopus_import: '1'
status: public
title: Environmental dynamics shape perceptual decision bias
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 19
year: '2023'
...
---
_id: '12349'
abstract:
- lang: eng
  text: Statistics of natural scenes are not uniform - their structure varies dramatically
    from ground to sky. It remains unknown whether these non-uniformities are reflected
    in the large-scale organization of the early visual system and what benefits such
    adaptations would confer. Here, by relying on the efficient coding hypothesis,
    we predict that changes in the structure of receptive fields across visual space
    increase the efficiency of sensory coding. We show experimentally that, in agreement
    with our predictions, receptive fields of retinal ganglion cells change their
    shape along the dorsoventral retinal axis, with a marked surround asymmetry at
    the visual horizon. Our work demonstrates that, according to principles of efficient
    coding, the panoramic structure of natural scenes is exploited by the retina across
    space and cell-types.
acknowledged_ssus:
- _id: ScienComp
- _id: PreCl
- _id: LifeSc
- _id: Bio
acknowledgement: We thank Hiroki Asari for sharing the dataset of naturalistic images,
  Anton Sumser for sharing visual stimulus code, Yoav Ben Simon for initial explorative
  work with the generation of AAVs, and Tomas Vega-Zuñiga for help with immunostainings.
  We also thank Gasper Tkacik and members of the Neuroethology group for their comments
  on the manuscript. This research was supported by the Scientific Service Units of
  IST Austria through resources provided by Scientific Computing, the Preclinical
  Facility, the Lab Support Facility, and the Imaging and Optics Facility. This work
  was supported by European Union Horizon 2020 Marie Skłodowska-Curie grant 665385
  (DG), Austrian Science Fund (FWF) stand-alone grant P 34015 (WM), Human Frontiers
  Science Program LT000256/2018-L (AS), EMBO ALTF 1098-2017 (AS) and the European
  Research Council Starting Grant 756502 (MJ).
article_processing_charge: Yes (in subscription journal)
article_type: original
author:
- first_name: Divyansh
  full_name: Gupta, Divyansh
  id: 2A485EBE-F248-11E8-B48F-1D18A9856A87
  last_name: Gupta
  orcid: 0000-0001-7400-6665
- first_name: Wiktor F
  full_name: Mlynarski, Wiktor F
  id: 358A453A-F248-11E8-B48F-1D18A9856A87
  last_name: Mlynarski
- first_name: Anton L
  full_name: Sumser, Anton L
  id: 3320A096-F248-11E8-B48F-1D18A9856A87
  last_name: Sumser
  orcid: 0000-0002-4792-1881
- first_name: Olga
  full_name: Symonova, Olga
  id: 3C0C7BC6-F248-11E8-B48F-1D18A9856A87
  last_name: Symonova
  orcid: 0000-0003-2012-9947
- first_name: Jan
  full_name: Svaton, Jan
  id: f7f724c3-9d6f-11ed-9f44-e5c5f3a5bee2
  last_name: Svaton
  orcid: 0000-0002-6198-2939
- first_name: Maximilian A
  full_name: Jösch, Maximilian A
  id: 2BD278E6-F248-11E8-B48F-1D18A9856A87
  last_name: Jösch
  orcid: 0000-0002-3937-1330
citation:
  ama: Gupta D, Mlynarski WF, Sumser AL, Symonova O, Svaton J, Jösch MA. Panoramic
    visual statistics shape retina-wide organization of receptive fields. <i>Nature
    Neuroscience</i>. 2023;26:606-614. doi:<a href="https://doi.org/10.1038/s41593-023-01280-0">10.1038/s41593-023-01280-0</a>
  apa: Gupta, D., Mlynarski, W. F., Sumser, A. L., Symonova, O., Svaton, J., &#38;
    Jösch, M. A. (2023). Panoramic visual statistics shape retina-wide organization
    of receptive fields. <i>Nature Neuroscience</i>. Springer Nature. <a href="https://doi.org/10.1038/s41593-023-01280-0">https://doi.org/10.1038/s41593-023-01280-0</a>
  chicago: Gupta, Divyansh, Wiktor F Mlynarski, Anton L Sumser, Olga Symonova, Jan
    Svaton, and Maximilian A Jösch. “Panoramic Visual Statistics Shape Retina-Wide
    Organization of Receptive Fields.” <i>Nature Neuroscience</i>. Springer Nature,
    2023. <a href="https://doi.org/10.1038/s41593-023-01280-0">https://doi.org/10.1038/s41593-023-01280-0</a>.
  ieee: D. Gupta, W. F. Mlynarski, A. L. Sumser, O. Symonova, J. Svaton, and M. A.
    Jösch, “Panoramic visual statistics shape retina-wide organization of receptive
    fields,” <i>Nature Neuroscience</i>, vol. 26. Springer Nature, pp. 606–614, 2023.
  ista: Gupta D, Mlynarski WF, Sumser AL, Symonova O, Svaton J, Jösch MA. 2023. Panoramic
    visual statistics shape retina-wide organization of receptive fields. Nature Neuroscience.
    26, 606–614.
  mla: Gupta, Divyansh, et al. “Panoramic Visual Statistics Shape Retina-Wide Organization
    of Receptive Fields.” <i>Nature Neuroscience</i>, vol. 26, Springer Nature, 2023,
    pp. 606–14, doi:<a href="https://doi.org/10.1038/s41593-023-01280-0">10.1038/s41593-023-01280-0</a>.
  short: D. Gupta, W.F. Mlynarski, A.L. Sumser, O. Symonova, J. Svaton, M.A. Jösch,
    Nature Neuroscience 26 (2023) 606–614.
date_created: 2023-01-23T14:14:19Z
date_published: 2023-04-01T00:00:00Z
date_updated: 2023-10-04T11:41:05Z
day: '01'
ddc:
- '570'
department:
- _id: GradSch
- _id: MaJö
doi: 10.1038/s41593-023-01280-0
ec_funded: 1
external_id:
  isi:
  - '000955258300002'
  pmid:
  - '36959418'
file:
- access_level: open_access
  checksum: a33d91e398e548f34003170e10988368
  content_type: application/pdf
  creator: dernst
  date_created: 2023-10-04T11:40:51Z
  date_updated: 2023-10-04T11:40:51Z
  file_id: '14395'
  file_name: 2023_NatureNeuroscience_Gupta.pdf
  file_size: 6144866
  relation: main_file
  success: 1
file_date_updated: 2023-10-04T11:40:51Z
has_accepted_license: '1'
intvolume: '        26'
isi: 1
language:
- iso: eng
month: '04'
oa: 1
oa_version: Published Version
page: 606-614
pmid: 1
project:
- _id: 2564DBCA-B435-11E9-9278-68D0E5697425
  call_identifier: H2020
  grant_number: '665385'
  name: International IST Doctoral Program
- _id: 626c45b5-2b32-11ec-9570-e509828c1ba6
  grant_number: P34015
  name: Efficient coding with biophysical realism
- _id: 2634E9D2-B435-11E9-9278-68D0E5697425
  call_identifier: H2020
  grant_number: '756502'
  name: Circuits of Visual Attention
- _id: 266D407A-B435-11E9-9278-68D0E5697425
  grant_number: LT000256
  name: Neuronal networks of salience and spatial detection in the murine superior
    colliculus
- _id: 264FEA02-B435-11E9-9278-68D0E5697425
  grant_number: ALTF 1098-2017
  name: Connecting sensory with motor processing in the superior colliculus
publication: Nature Neuroscience
publication_identifier:
  eissn:
  - 1546-1726
  issn:
  - 1097-6256
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
related_material:
  record:
  - id: '12370'
    relation: research_data
    status: public
scopus_import: '1'
status: public
title: Panoramic visual statistics shape retina-wide organization of receptive fields
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 26
year: '2023'
...
---
_id: '12332'
abstract:
- lang: eng
  text: Activity of sensory neurons is driven not only by external stimuli but also
    by feedback signals from higher brain areas. Attention is one particularly important
    internal signal whose presumed role is to modulate sensory representations such
    that they only encode information currently relevant to the organism at minimal
    cost. This hypothesis has, however, not yet been expressed in a normative computational
    framework. Here, by building on normative principles of probabilistic inference
    and efficient coding, we developed a model of dynamic population coding in the
    visual cortex. By continuously adapting the sensory code to changing demands of
    the perceptual observer, an attention-like modulation emerges. This modulation
    can dramatically reduce the amount of neural activity without deteriorating the
    accuracy of task-specific inferences. Our results suggest that a range of seemingly
    disparate cortical phenomena such as intrinsic gain modulation, attention-related
    tuning modulation, and response variability could be manifestations of the same
    underlying principles, which combine efficient sensory coding with optimal probabilistic
    inference in dynamic environments.
acknowledgement: "We thank Robbe Goris for generously providing figures from his work
  and Ann M. Hermundstad for helpful discussions.\r\nGT & WM were supported by the
  Austrian Science Fund Standalone Grant P 34015 \"Efficient Coding with Biophysical
  Realism\" (https://pf.fwf.ac.at/) WM was additionally supported by the European
  Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie
  Grant Agreement No. 754411 (https://ec.europa.eu/research/mariecurieactions/). The
  funders had no role in study design, data collection and analysis, decision to publish,
  or preparation of the manuscript."
article_processing_charge: No
article_type: original
author:
- first_name: Wiktor F
  full_name: Mlynarski, Wiktor F
  id: 358A453A-F248-11E8-B48F-1D18A9856A87
  last_name: Mlynarski
- first_name: Gašper
  full_name: Tkačik, Gašper
  id: 3D494DCA-F248-11E8-B48F-1D18A9856A87
  last_name: Tkačik
  orcid: '1'
citation:
  ama: Mlynarski WF, Tkačik G. Efficient coding theory of dynamic attentional modulation.
    <i>PLoS Biology</i>. 2022;20(12):e3001889. doi:<a href="https://doi.org/10.1371/journal.pbio.3001889">10.1371/journal.pbio.3001889</a>
  apa: Mlynarski, W. F., &#38; Tkačik, G. (2022). Efficient coding theory of dynamic
    attentional modulation. <i>PLoS Biology</i>. Public Library of Science. <a href="https://doi.org/10.1371/journal.pbio.3001889">https://doi.org/10.1371/journal.pbio.3001889</a>
  chicago: Mlynarski, Wiktor F, and Gašper Tkačik. “Efficient Coding Theory of Dynamic
    Attentional Modulation.” <i>PLoS Biology</i>. Public Library of Science, 2022.
    <a href="https://doi.org/10.1371/journal.pbio.3001889">https://doi.org/10.1371/journal.pbio.3001889</a>.
  ieee: W. F. Mlynarski and G. Tkačik, “Efficient coding theory of dynamic attentional
    modulation,” <i>PLoS Biology</i>, vol. 20, no. 12. Public Library of Science,
    p. e3001889, 2022.
  ista: Mlynarski WF, Tkačik G. 2022. Efficient coding theory of dynamic attentional
    modulation. PLoS Biology. 20(12), e3001889.
  mla: Mlynarski, Wiktor F., and Gašper Tkačik. “Efficient Coding Theory of Dynamic
    Attentional Modulation.” <i>PLoS Biology</i>, vol. 20, no. 12, Public Library
    of Science, 2022, p. e3001889, doi:<a href="https://doi.org/10.1371/journal.pbio.3001889">10.1371/journal.pbio.3001889</a>.
  short: W.F. Mlynarski, G. Tkačik, PLoS Biology 20 (2022) e3001889.
date_created: 2023-01-22T23:00:55Z
date_published: 2022-12-21T00:00:00Z
date_updated: 2023-08-03T14:23:49Z
day: '21'
ddc:
- '570'
department:
- _id: GaTk
doi: 10.1371/journal.pbio.3001889
ec_funded: 1
external_id:
  isi:
  - '000925192000001'
file:
- access_level: open_access
  checksum: 5d7f1111a87e5f2c1bf92f8886738894
  content_type: application/pdf
  creator: dernst
  date_created: 2023-01-23T08:46:40Z
  date_updated: 2023-01-23T08:46:40Z
  file_id: '12337'
  file_name: 2022_PloSBiology_Mlynarski.pdf
  file_size: 4248838
  relation: main_file
  success: 1
file_date_updated: 2023-01-23T08:46:40Z
has_accepted_license: '1'
intvolume: '        20'
isi: 1
issue: '12'
language:
- iso: eng
month: '12'
oa: 1
oa_version: Published Version
page: e3001889
project:
- _id: 626c45b5-2b32-11ec-9570-e509828c1ba6
  grant_number: P34015
  name: Efficient coding with biophysical realism
- _id: 260C2330-B435-11E9-9278-68D0E5697425
  call_identifier: H2020
  grant_number: '754411'
  name: ISTplus - Postdoctoral Fellowships
publication: PLoS Biology
publication_identifier:
  eissn:
  - 1545-7885
publication_status: published
publisher: Public Library of Science
quality_controlled: '1'
scopus_import: '1'
status: public
title: Efficient coding theory of dynamic attentional modulation
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 20
year: '2022'
...
---
_id: '7553'
abstract:
- lang: eng
  text: Normative theories and statistical inference provide complementary approaches
    for the study of biological systems. A normative theory postulates that organisms
    have adapted to efficiently solve essential tasks, and proceeds to mathematically
    work out testable consequences of such optimality; parameters that maximize the
    hypothesized organismal function can be derived ab initio, without reference to
    experimental data. In contrast, statistical inference focuses on efficient utilization
    of data to learn model parameters, without reference to any a priori notion of
    biological function, utility, or fitness. Traditionally, these two approaches
    were developed independently and applied separately. Here we unify them in a coherent
    Bayesian framework that embeds a normative theory into a family of maximum-entropy
    “optimization priors.” This family defines a smooth interpolation between a data-rich
    inference regime (characteristic of “bottom-up” statistical models), and a data-limited
    ab inito prediction regime (characteristic of “top-down” normative theory). We
    demonstrate the applicability of our framework using data from the visual cortex,
    and argue that the flexibility it affords is essential to address a number of
    fundamental challenges relating to inference and prediction in complex, high-dimensional
    biological problems.
acknowledgement: The authors thank Dario Ringach for providing the V1 receptive fields
  and Olivier Marre for providing the retinal receptive fields. W.M. was funded by
  the European Union’s Horizon 2020 research and innovation programme under the Marie
  Skłodowska-Curie grant agreement no. 754411. M.H. was funded in part by Human Frontiers
  Science grant no. HFSP RGP0032/2018.
article_processing_charge: No
author:
- first_name: Wiktor F
  full_name: Mlynarski, Wiktor F
  id: 358A453A-F248-11E8-B48F-1D18A9856A87
  last_name: Mlynarski
- first_name: Michal
  full_name: Hledik, Michal
  id: 4171253A-F248-11E8-B48F-1D18A9856A87
  last_name: Hledik
- first_name: Thomas R
  full_name: Sokolowski, Thomas R
  id: 3E999752-F248-11E8-B48F-1D18A9856A87
  last_name: Sokolowski
  orcid: 0000-0002-1287-3779
- first_name: Gašper
  full_name: Tkačik, Gašper
  id: 3D494DCA-F248-11E8-B48F-1D18A9856A87
  last_name: Tkačik
  orcid: 0000-0002-6699-1455
citation:
  ama: Mlynarski WF, Hledik M, Sokolowski TR, Tkačik G. Statistical analysis and optimality
    of neural systems. <i>Neuron</i>. 2021;109(7):1227-1241.e5. doi:<a href="https://doi.org/10.1016/j.neuron.2021.01.020">10.1016/j.neuron.2021.01.020</a>
  apa: Mlynarski, W. F., Hledik, M., Sokolowski, T. R., &#38; Tkačik, G. (2021). Statistical
    analysis and optimality of neural systems. <i>Neuron</i>. Cell Press. <a href="https://doi.org/10.1016/j.neuron.2021.01.020">https://doi.org/10.1016/j.neuron.2021.01.020</a>
  chicago: Mlynarski, Wiktor F, Michal Hledik, Thomas R Sokolowski, and Gašper Tkačik.
    “Statistical Analysis and Optimality of Neural Systems.” <i>Neuron</i>. Cell Press,
    2021. <a href="https://doi.org/10.1016/j.neuron.2021.01.020">https://doi.org/10.1016/j.neuron.2021.01.020</a>.
  ieee: W. F. Mlynarski, M. Hledik, T. R. Sokolowski, and G. Tkačik, “Statistical
    analysis and optimality of neural systems,” <i>Neuron</i>, vol. 109, no. 7. Cell
    Press, p. 1227–1241.e5, 2021.
  ista: Mlynarski WF, Hledik M, Sokolowski TR, Tkačik G. 2021. Statistical analysis
    and optimality of neural systems. Neuron. 109(7), 1227–1241.e5.
  mla: Mlynarski, Wiktor F., et al. “Statistical Analysis and Optimality of Neural
    Systems.” <i>Neuron</i>, vol. 109, no. 7, Cell Press, 2021, p. 1227–1241.e5, doi:<a
    href="https://doi.org/10.1016/j.neuron.2021.01.020">10.1016/j.neuron.2021.01.020</a>.
  short: W.F. Mlynarski, M. Hledik, T.R. Sokolowski, G. Tkačik, Neuron 109 (2021)
    1227–1241.e5.
date_created: 2020-02-28T11:00:12Z
date_published: 2021-04-07T00:00:00Z
date_updated: 2025-06-30T13:21:05Z
day: '07'
department:
- _id: GaTk
doi: 10.1016/j.neuron.2021.01.020
ec_funded: 1
external_id:
  isi:
  - '000637809600006'
intvolume: '       109'
isi: 1
issue: '7'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://doi.org/10.1101/848374
month: '04'
oa: 1
oa_version: Preprint
page: 1227-1241.e5
project:
- _id: 260C2330-B435-11E9-9278-68D0E5697425
  call_identifier: H2020
  grant_number: '754411'
  name: ISTplus - Postdoctoral Fellowships
publication: Neuron
publication_status: published
publisher: Cell Press
quality_controlled: '1'
related_material:
  link:
  - description: News on IST Homepage
    relation: press_release
    url: https://ist.ac.at/en/news/can-evolution-be-predicted/
  record:
  - id: '15020'
    relation: dissertation_contains
    status: public
scopus_import: '1'
status: public
title: Statistical analysis and optimality of neural systems
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 109
year: '2021'
...
---
_id: '9439'
abstract:
- lang: eng
  text: The ability to adapt to changes in stimulus statistics is a hallmark of sensory
    systems. Here, we developed a theoretical framework that can account for the dynamics
    of adaptation from an information processing perspective. We use this framework
    to optimize and analyze adaptive sensory codes, and we show that codes optimized
    for stationary environments can suffer from prolonged periods of poor performance
    when the environment changes. To mitigate the adversarial effects of these environmental
    changes, sensory systems must navigate tradeoffs between the ability to accurately
    encode incoming stimuli and the ability to rapidly detect and adapt to changes
    in the distribution of these stimuli. We derive families of codes that balance
    these objectives, and we demonstrate their close match to experimentally observed
    neural dynamics during mean and variance adaptation. Our results provide a unifying
    perspective on adaptation across a range of sensory systems, environments, and
    sensory tasks.
acknowledgement: We thank D. Kastner and T. Münch for generously providing figures
  from their work. We also thank V. Jayaraman, M. Noorman, T. Ma, and K. Krishnamurthy
  for useful discussions and feedback on the manuscript. W.F.M. was funded by the
  European Union’s Horizon 2020 Research and Innovation Programme under Marie Skłodowska-Curie
  Grant Agreement No. 754411. A.M.H. was supported by the Howard Hughes Medical Institute.
article_processing_charge: No
article_type: original
author:
- first_name: Wiktor F
  full_name: Mlynarski, Wiktor F
  id: 358A453A-F248-11E8-B48F-1D18A9856A87
  last_name: Mlynarski
- first_name: Ann M.
  full_name: Hermundstad, Ann M.
  last_name: Hermundstad
citation:
  ama: Mlynarski WF, Hermundstad AM. Efficient and adaptive sensory codes. <i>Nature
    Neuroscience</i>. 2021;24:998-1009. doi:<a href="https://doi.org/10.1038/s41593-021-00846-0">10.1038/s41593-021-00846-0</a>
  apa: Mlynarski, W. F., &#38; Hermundstad, A. M. (2021). Efficient and adaptive sensory
    codes. <i>Nature Neuroscience</i>. Springer Nature. <a href="https://doi.org/10.1038/s41593-021-00846-0">https://doi.org/10.1038/s41593-021-00846-0</a>
  chicago: Mlynarski, Wiktor F, and Ann M. Hermundstad. “Efficient and Adaptive Sensory
    Codes.” <i>Nature Neuroscience</i>. Springer Nature, 2021. <a href="https://doi.org/10.1038/s41593-021-00846-0">https://doi.org/10.1038/s41593-021-00846-0</a>.
  ieee: W. F. Mlynarski and A. M. Hermundstad, “Efficient and adaptive sensory codes,”
    <i>Nature Neuroscience</i>, vol. 24. Springer Nature, pp. 998–1009, 2021.
  ista: Mlynarski WF, Hermundstad AM. 2021. Efficient and adaptive sensory codes.
    Nature Neuroscience. 24, 998–1009.
  mla: Mlynarski, Wiktor F., and Ann M. Hermundstad. “Efficient and Adaptive Sensory
    Codes.” <i>Nature Neuroscience</i>, vol. 24, Springer Nature, 2021, pp. 998–1009,
    doi:<a href="https://doi.org/10.1038/s41593-021-00846-0">10.1038/s41593-021-00846-0</a>.
  short: W.F. Mlynarski, A.M. Hermundstad, Nature Neuroscience 24 (2021) 998–1009.
date_created: 2021-05-30T22:01:24Z
date_published: 2021-05-20T00:00:00Z
date_updated: 2023-08-08T13:51:14Z
day: '20'
department:
- _id: GaTk
doi: 10.1038/s41593-021-00846-0
ec_funded: 1
external_id:
  isi:
  - '000652577300003'
intvolume: '        24'
isi: 1
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: 'https://doi.org/10.1101/669200 '
month: '05'
oa: 1
oa_version: Preprint
page: 998-1009
project:
- _id: 260C2330-B435-11E9-9278-68D0E5697425
  call_identifier: H2020
  grant_number: '754411'
  name: ISTplus - Postdoctoral Fellowships
publication: Nature Neuroscience
publication_identifier:
  eissn:
  - 1546-1726
  issn:
  - 1097-6256
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: Efficient and adaptive sensory codes
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 24
year: '2021'
...
