---
_id: '960'
abstract:
- lang: eng
  text: The human cerebral cortex is the seat of our cognitive abilities and composed
    of an extraordinary number of neurons, organized in six distinct layers. The establishment
    of specific morphological and physiological features in individual neurons needs
    to be regulated with high precision. Impairments in the sequential developmental
    programs instructing corticogenesis lead to alterations in the cortical cytoarchitecture
    which is thought to represent the major underlying cause for several neurological
    disorders including neurodevelopmental and psychiatric diseases. In this review
    we discuss the role of cell polarity at sequential stages during cortex development.
    We first provide an overview of morphological cell polarity features in cortical
    neural stem cells and newly-born postmitotic neurons. We then synthesize a conceptual
    molecular and biochemical framework how cell polarity is established at the cellular
    level through a break in symmetry in nascent cortical projection neurons. Lastly
    we provide a perspective how the molecular mechanisms applying to single cells
    could be probed and integrated in an in vivo and tissue-wide context.
article_number: '176'
article_processing_charge: Yes
author:
- first_name: Andi H
  full_name: Hansen, Andi H
  id: 38853E16-F248-11E8-B48F-1D18A9856A87
  last_name: Hansen
- first_name: Christian F
  full_name: Düllberg, Christian F
  id: 459064DC-F248-11E8-B48F-1D18A9856A87
  last_name: Düllberg
  orcid: 0000-0001-6335-9748
- first_name: Christine
  full_name: Mieck, Christine
  id: 34CAE85C-F248-11E8-B48F-1D18A9856A87
  last_name: Mieck
  orcid: 0000-0003-1919-7416
- first_name: Martin
  full_name: Loose, Martin
  id: 462D4284-F248-11E8-B48F-1D18A9856A87
  last_name: Loose
  orcid: 0000-0001-7309-9724
- first_name: Simon
  full_name: Hippenmeyer, Simon
  id: 37B36620-F248-11E8-B48F-1D18A9856A87
  last_name: Hippenmeyer
  orcid: 0000-0003-2279-1061
citation:
  ama: Hansen AH, Düllberg CF, Mieck C, Loose M, Hippenmeyer S. Cell polarity in cerebral
    cortex development - cellular architecture shaped by biochemical networks. <i>Frontiers
    in Cellular Neuroscience</i>. 2017;11. doi:<a href="https://doi.org/10.3389/fncel.2017.00176">10.3389/fncel.2017.00176</a>
  apa: Hansen, A. H., Düllberg, C. F., Mieck, C., Loose, M., &#38; Hippenmeyer, S.
    (2017). Cell polarity in cerebral cortex development - cellular architecture shaped
    by biochemical networks. <i>Frontiers in Cellular Neuroscience</i>. Frontiers
    Research Foundation. <a href="https://doi.org/10.3389/fncel.2017.00176">https://doi.org/10.3389/fncel.2017.00176</a>
  chicago: Hansen, Andi H, Christian F Düllberg, Christine Mieck, Martin Loose, and
    Simon Hippenmeyer. “Cell Polarity in Cerebral Cortex Development - Cellular Architecture
    Shaped by Biochemical Networks.” <i>Frontiers in Cellular Neuroscience</i>. Frontiers
    Research Foundation, 2017. <a href="https://doi.org/10.3389/fncel.2017.00176">https://doi.org/10.3389/fncel.2017.00176</a>.
  ieee: A. H. Hansen, C. F. Düllberg, C. Mieck, M. Loose, and S. Hippenmeyer, “Cell
    polarity in cerebral cortex development - cellular architecture shaped by biochemical
    networks,” <i>Frontiers in Cellular Neuroscience</i>, vol. 11. Frontiers Research
    Foundation, 2017.
  ista: Hansen AH, Düllberg CF, Mieck C, Loose M, Hippenmeyer S. 2017. Cell polarity
    in cerebral cortex development - cellular architecture shaped by biochemical networks.
    Frontiers in Cellular Neuroscience. 11, 176.
  mla: Hansen, Andi H., et al. “Cell Polarity in Cerebral Cortex Development - Cellular
    Architecture Shaped by Biochemical Networks.” <i>Frontiers in Cellular Neuroscience</i>,
    vol. 11, 176, Frontiers Research Foundation, 2017, doi:<a href="https://doi.org/10.3389/fncel.2017.00176">10.3389/fncel.2017.00176</a>.
  short: A.H. Hansen, C.F. Düllberg, C. Mieck, M. Loose, S. Hippenmeyer, Frontiers
    in Cellular Neuroscience 11 (2017).
date_created: 2018-12-11T11:49:25Z
date_published: 2017-06-28T00:00:00Z
date_updated: 2024-03-25T23:30:23Z
day: '28'
ddc:
- '570'
department:
- _id: SiHi
- _id: MaLo
doi: 10.3389/fncel.2017.00176
ec_funded: 1
external_id:
  isi:
  - '000404486700001'
file:
- access_level: open_access
  checksum: dc1f5a475b918d09a0f9f587400b1626
  content_type: application/pdf
  creator: system
  date_created: 2018-12-12T10:09:40Z
  date_updated: 2020-07-14T12:48:16Z
  file_id: '4764'
  file_name: IST-2017-830-v1+1_2017_Hansen_CellPolarity.pdf
  file_size: 2153858
  relation: main_file
file_date_updated: 2020-07-14T12:48:16Z
has_accepted_license: '1'
intvolume: '        11'
isi: 1
language:
- iso: eng
month: '06'
oa: 1
oa_version: Published Version
project:
- _id: 25D61E48-B435-11E9-9278-68D0E5697425
  call_identifier: FP7
  grant_number: '618444'
  name: Molecular Mechanisms of Cerebral Cortex Development
- _id: 25D7962E-B435-11E9-9278-68D0E5697425
  grant_number: RGP0053/2014
  name: Quantitative Structure-Function Analysis of Cerebral Cortex Assembly at Clonal
    Level
- _id: 25681D80-B435-11E9-9278-68D0E5697425
  call_identifier: FP7
  grant_number: '291734'
  name: International IST Postdoc Fellowship Programme
- _id: 25985A36-B435-11E9-9278-68D0E5697425
  call_identifier: FWF
  grant_number: T00817-B21
  name: The biochemical basis of PAR polarization
publication: Frontiers in Cellular Neuroscience
publication_identifier:
  issn:
  - '16625102'
publication_status: published
publisher: Frontiers Research Foundation
publist_id: '6445'
pubrep_id: '830'
quality_controlled: '1'
related_material:
  record:
  - id: '9962'
    relation: dissertation_contains
    status: public
scopus_import: '1'
status: public
title: Cell polarity in cerebral cortex development - cellular architecture shaped
  by biochemical networks
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 11
year: '2017'
...