---
_id: '14058'
abstract:
- lang: eng
  text: "Females and males across species are subject to divergent selective pressures
    arising\r\nfrom di↵erent reproductive interests and ecological niches. This often
    translates into a\r\nintricate array of sex-specific natural and sexual selection
    on traits that have a shared\r\ngenetic basis between both sexes, causing a genetic
    sexual conflict. The resolution of\r\nthis conflict mostly relies on the evolution
    of sex-specific expression of the shared genes,\r\nleading to phenotypic sexual
    dimorphism. Such sex-specific gene expression is thought\r\nto evolve via modifications
    of the genetic networks ultimately linked to sex-determining\r\ntranscription
    factors. Although much empirical and theoretical evidence supports this\r\nstandard
    picture of the molecular basis of sexual conflict resolution, there still are
    a\r\nfew open questions regarding the complex array of selective forces driving
    phenotypic\r\ndi↵erentiation between the sexes, as well as the molecular mechanisms
    underlying sexspecific adaptation. I address some of these open questions in my
    PhD thesis.\r\nFirst, how do patterns of phenotypic sexual dimorphism vary within
    populations,\r\nas a response to the temporal and spatial changes in sex-specific
    selective forces? To\r\ntackle this question, I analyze the patterns of sex-specific
    phenotypic variation along\r\nthree life stages and across populations spanning
    the whole geographical range of Rumex\r\nhastatulus, a wind-pollinated angiosperm,
    in the first Chapter of the thesis.\r\nSecond, how do gene expression patterns
    lead to phenotypic dimorphism, and what\r\nare the molecular mechanisms underlying
    the observed transcriptomic variation? I\r\naddress this question by examining
    the sex- and tissue-specific expression variation in\r\nnewly-generated datasets
    of sex-specific expression in heads and gonads of Drosophila\r\nmelanogaster.
    I additionally used two complementary approaches for the study of the\r\ngenetic
    basis of sex di↵erences in gene expression in the second and third Chapters of\r\nthe
    thesis.\r\nThird, how does intersex correlation, thought to be one of the main
    aspects constraining the ability for the two sexes to decouple, interact with
    the evolution of sexual\r\ndimorphism? I develop models of sex-specific stabilizing
    selection, mutation and drift\r\nto formalize common intuition regarding the patterns
    of covariation between intersex\r\ncorrelation and sexual dimorphism in the fourth
    Chapter of the thesis.\r\nAlltogether, the work described in this PhD thesis provides
    useful insights into the\r\nlinks between genetic, transcriptomic and phenotypic
    layers of sex-specific variation,\r\nand contributes to our general understanding
    of the dynamics of sexual dimorphism\r\nevolution."
alternative_title:
- ISTA Thesis
article_processing_charge: No
author:
- first_name: Gemma
  full_name: Puixeu Sala, Gemma
  id: 33AB266C-F248-11E8-B48F-1D18A9856A87
  last_name: Puixeu Sala
  orcid: 0000-0001-8330-1754
citation:
  ama: 'Puixeu Sala G. The molecular basis of sexual dimorphism: Experimental and
    theoretical characterization of phenotypic, transcriptomic and genetic patterns
    of sex-specific adaptation. 2023. doi:<a href="https://doi.org/10.15479/at:ista:14058">10.15479/at:ista:14058</a>'
  apa: 'Puixeu Sala, G. (2023). <i>The molecular basis of sexual dimorphism: Experimental
    and theoretical characterization of phenotypic, transcriptomic and genetic patterns
    of sex-specific adaptation</i>. Institute of Science and Technology Austria. <a
    href="https://doi.org/10.15479/at:ista:14058">https://doi.org/10.15479/at:ista:14058</a>'
  chicago: 'Puixeu Sala, Gemma. “The Molecular Basis of Sexual Dimorphism: Experimental
    and Theoretical Characterization of Phenotypic, Transcriptomic and Genetic Patterns
    of Sex-Specific Adaptation.” Institute of Science and Technology Austria, 2023.
    <a href="https://doi.org/10.15479/at:ista:14058">https://doi.org/10.15479/at:ista:14058</a>.'
  ieee: 'G. Puixeu Sala, “The molecular basis of sexual dimorphism: Experimental and
    theoretical characterization of phenotypic, transcriptomic and genetic patterns
    of sex-specific adaptation,” Institute of Science and Technology Austria, 2023.'
  ista: 'Puixeu Sala G. 2023. The molecular basis of sexual dimorphism: Experimental
    and theoretical characterization of phenotypic, transcriptomic and genetic patterns
    of sex-specific adaptation. Institute of Science and Technology Austria.'
  mla: 'Puixeu Sala, Gemma. <i>The Molecular Basis of Sexual Dimorphism: Experimental
    and Theoretical Characterization of Phenotypic, Transcriptomic and Genetic Patterns
    of Sex-Specific Adaptation</i>. Institute of Science and Technology Austria, 2023,
    doi:<a href="https://doi.org/10.15479/at:ista:14058">10.15479/at:ista:14058</a>.'
  short: 'G. Puixeu Sala, The Molecular Basis of Sexual Dimorphism: Experimental and
    Theoretical Characterization of Phenotypic, Transcriptomic and Genetic Patterns
    of Sex-Specific Adaptation, Institute of Science and Technology Austria, 2023.'
date_created: 2023-08-15T10:20:40Z
date_published: 2023-08-15T00:00:00Z
date_updated: 2023-12-13T12:15:36Z
day: '15'
ddc:
- '576'
degree_awarded: PhD
department:
- _id: GradSch
- _id: NiBa
- _id: BeVi
doi: 10.15479/at:ista:14058
ec_funded: 1
file:
- access_level: closed
  checksum: 4e44e169f2724ee8c9324cd60bcc2b71
  content_type: application/zip
  creator: gpuixeus
  date_created: 2023-08-16T18:15:17Z
  date_updated: 2023-08-17T06:55:24Z
  file_id: '14075'
  file_name: Thesis_latex_forpdfa.zip
  file_size: 10891454
  relation: source_file
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  checksum: e10b04cd8f3fecc0d9ef6e6868b6e1e8
  content_type: application/pdf
  creator: gpuixeus
  date_created: 2023-08-18T10:47:55Z
  date_updated: 2023-08-18T10:47:55Z
  file_id: '14079'
  file_name: PhDThesis_PuixeuG.pdf
  file_size: 19856686
  relation: main_file
  success: 1
file_date_updated: 2023-08-18T10:47:55Z
has_accepted_license: '1'
language:
- iso: eng
month: '08'
oa: 1
oa_version: Published Version
page: '230'
project:
- _id: 2564DBCA-B435-11E9-9278-68D0E5697425
  call_identifier: H2020
  grant_number: '665385'
  name: International IST Doctoral Program
- _id: 9B9DFC9E-BA93-11EA-9121-9846C619BF3A
  grant_number: '25817'
  name: 'Sexual conflict: resolution, constraints and biomedical implications'
publication_identifier:
  isbn:
  - 978-3-99078-035-0
  issn:
  - 2663-337X
publication_status: published
publisher: Institute of Science and Technology Austria
related_material:
  record:
  - id: '9803'
    relation: research_data
    status: public
  - id: '12933'
    relation: research_data
    status: public
  - id: '6831'
    relation: part_of_dissertation
    status: public
  - id: '14077'
    relation: part_of_dissertation
    status: public
status: public
supervisor:
- first_name: Beatriz
  full_name: Vicoso, Beatriz
  id: 49E1C5C6-F248-11E8-B48F-1D18A9856A87
  last_name: Vicoso
  orcid: 0000-0002-4579-8306
- first_name: Nicholas H
  full_name: Barton, Nicholas H
  id: 4880FE40-F248-11E8-B48F-1D18A9856A87
  last_name: Barton
  orcid: 0000-0002-8548-5240
title: 'The molecular basis of sexual dimorphism: Experimental and theoretical characterization
  of phenotypic, transcriptomic and genetic patterns of sex-specific adaptation'
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: dissertation
user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
year: '2023'
...
---
_id: '14077'
abstract:
- lang: eng
  text: "The regulatory architecture of gene expression is known to differ substantially
    between sexes in Drosophila, but most studies performed\r\nso far used whole-body
    data and only single crosses, which may have limited their scope to detect patterns
    that are robust across tissues\r\nand biological replicates. Here, we use allele-specific
    gene expression of parental and reciprocal hybrid crosses between 6 Drosophila\r\nmelanogaster
    inbred lines to quantify cis- and trans-regulatory variation in heads and gonads
    of both sexes separately across 3 replicate\r\ncrosses. Our results suggest that
    female and male heads, as well as ovaries, have a similar regulatory architecture.
    On the other hand,\r\ntestes display more and substantially different cis-regulatory
    effects, suggesting that sex differences in the regulatory architecture that\r\nhave
    been previously observed may largely derive from testis-specific effects. We also
    examine the difference in cis-regulatory variation\r\nof genes across different
    levels of sex bias in gonads and heads. Consistent with the idea that intersex
    correlations constrain expression\r\nand can lead to sexual antagonism, we find
    more cis variation in unbiased and moderately biased genes in heads. In ovaries,
    reduced cis\r\nvariation is observed for male-biased genes, suggesting that cis
    variants acting on these genes in males do not lead to changes in ovary\r\nexpression.
    Finally, we examine the dominance patterns of gene expression and find that sex-
    and tissue-specific patterns of inheritance\r\nas well as trans-regulatory variation
    are highly variable across biological crosses, although these were performed in
    highly controlled\r\nexperimental conditions. This highlights the importance of
    using various genetic backgrounds to infer generalizable patterns."
acknowledged_ssus:
- _id: ScienComp
acknowledgement: We thank members of the Vicoso Group for comments on the manuscript,
  the Scientific Computing Unit at ISTA for technical support, and 2 anonymous reviewers
  for useful feedback. GP is the recipient of a DOC Fellowship of the Austrian Academy
  of Sciences at the Institute of Science and Technology Austria (DOC 25817) and received
  funding from the European Union’s Horizon 2020 research and innovation program under
  the Marie Skłodowska-Curie Grant (agreement no. 665385).
article_processing_charge: Yes
article_type: original
author:
- first_name: Gemma
  full_name: Puixeu Sala, Gemma
  id: 33AB266C-F248-11E8-B48F-1D18A9856A87
  last_name: Puixeu Sala
  orcid: 0000-0001-8330-1754
- first_name: Ariana
  full_name: Macon, Ariana
  id: 2A0848E2-F248-11E8-B48F-1D18A9856A87
  last_name: Macon
- first_name: Beatriz
  full_name: Vicoso, Beatriz
  id: 49E1C5C6-F248-11E8-B48F-1D18A9856A87
  last_name: Vicoso
  orcid: 0000-0002-4579-8306
citation:
  ama: 'Puixeu Sala G, Macon A, Vicoso B. Sex-specific estimation of cis and trans
    regulation of gene expression in heads and gonads of Drosophila melanogaster.
    <i>G3: Genes, Genomes, Genetics</i>. 2023;13(8). doi:<a href="https://doi.org/10.1093/g3journal/jkad121">10.1093/g3journal/jkad121</a>'
  apa: 'Puixeu Sala, G., Macon, A., &#38; Vicoso, B. (2023). Sex-specific estimation
    of cis and trans regulation of gene expression in heads and gonads of Drosophila
    melanogaster. <i>G3: Genes, Genomes, Genetics</i>. Oxford University Press. <a
    href="https://doi.org/10.1093/g3journal/jkad121">https://doi.org/10.1093/g3journal/jkad121</a>'
  chicago: 'Puixeu Sala, Gemma, Ariana Macon, and Beatriz Vicoso. “Sex-Specific Estimation
    of Cis and Trans Regulation of Gene Expression in Heads and Gonads of Drosophila
    Melanogaster.” <i>G3: Genes, Genomes, Genetics</i>. Oxford University Press, 2023.
    <a href="https://doi.org/10.1093/g3journal/jkad121">https://doi.org/10.1093/g3journal/jkad121</a>.'
  ieee: 'G. Puixeu Sala, A. Macon, and B. Vicoso, “Sex-specific estimation of cis
    and trans regulation of gene expression in heads and gonads of Drosophila melanogaster,”
    <i>G3: Genes, Genomes, Genetics</i>, vol. 13, no. 8. Oxford University Press,
    2023.'
  ista: 'Puixeu Sala G, Macon A, Vicoso B. 2023. Sex-specific estimation of cis and
    trans regulation of gene expression in heads and gonads of Drosophila melanogaster.
    G3: Genes, Genomes, Genetics. 13(8).'
  mla: 'Puixeu Sala, Gemma, et al. “Sex-Specific Estimation of Cis and Trans Regulation
    of Gene Expression in Heads and Gonads of Drosophila Melanogaster.” <i>G3: Genes,
    Genomes, Genetics</i>, vol. 13, no. 8, Oxford University Press, 2023, doi:<a href="https://doi.org/10.1093/g3journal/jkad121">10.1093/g3journal/jkad121</a>.'
  short: 'G. Puixeu Sala, A. Macon, B. Vicoso, G3: Genes, Genomes, Genetics 13 (2023).'
date_created: 2023-08-18T06:52:14Z
date_published: 2023-08-01T00:00:00Z
date_updated: 2023-12-13T12:15:37Z
day: '01'
ddc:
- '570'
department:
- _id: BeVi
- _id: NiBa
- _id: GradSch
doi: 10.1093/g3journal/jkad121
ec_funded: 1
external_id:
  isi:
  - '001002997200001'
file:
- access_level: open_access
  checksum: c62e29fc7c5efbf8356f4c60cab4a2d1
  content_type: application/pdf
  creator: dernst
  date_created: 2023-11-07T09:00:19Z
  date_updated: 2023-11-07T09:00:19Z
  file_id: '14498'
  file_name: 2023_G3_Puixeu.pdf
  file_size: 845642
  relation: main_file
  success: 1
file_date_updated: 2023-11-07T09:00:19Z
has_accepted_license: '1'
intvolume: '        13'
isi: 1
issue: '8'
keyword:
- Genetics (clinical)
- Genetics
- Molecular Biology
language:
- iso: eng
month: '08'
oa: 1
oa_version: Published Version
project:
- _id: 2564DBCA-B435-11E9-9278-68D0E5697425
  call_identifier: H2020
  grant_number: '665385'
  name: International IST Doctoral Program
- _id: 9B9DFC9E-BA93-11EA-9121-9846C619BF3A
  grant_number: '25817'
  name: 'Sexual conflict: resolution, constraints and biomedical implications'
publication: 'G3: Genes, Genomes, Genetics'
publication_identifier:
  issn:
  - 2160-1836
publication_status: published
publisher: Oxford University Press
quality_controlled: '1'
related_material:
  record:
  - id: '12933'
    relation: research_data
    status: public
  - id: '14058'
    relation: dissertation_contains
    status: public
scopus_import: '1'
status: public
title: Sex-specific estimation of cis and trans regulation of gene expression in heads
  and gonads of Drosophila melanogaster
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 13
year: '2023'
...
---
_id: '12933'
abstract:
- lang: eng
  text: Datasets of the publication "Sex-specific estimation of cis and trans regulation
    of gene expression in heads and gonads of Drosophila melanogaster".
article_processing_charge: No
author:
- first_name: Gemma
  full_name: Puixeu Sala, Gemma
  id: 33AB266C-F248-11E8-B48F-1D18A9856A87
  last_name: Puixeu Sala
  orcid: 0000-0001-8330-1754
citation:
  ama: 'Puixeu Sala G. Data from: Sex-specific estimation of cis and trans regulation
    of gene expression in heads and gonads of Drosophila melanogaster. 2023. doi:<a
    href="https://doi.org/10.15479/AT:ISTA:12933">10.15479/AT:ISTA:12933</a>'
  apa: 'Puixeu Sala, G. (2023). Data from: Sex-specific estimation of cis and trans
    regulation of gene expression in heads and gonads of Drosophila melanogaster.
    Institute of Science and Technology Austria. <a href="https://doi.org/10.15479/AT:ISTA:12933">https://doi.org/10.15479/AT:ISTA:12933</a>'
  chicago: 'Puixeu Sala, Gemma. “Data from: Sex-Specific Estimation of Cis and Trans
    Regulation of Gene Expression in Heads and Gonads of Drosophila Melanogaster.”
    Institute of Science and Technology Austria, 2023. <a href="https://doi.org/10.15479/AT:ISTA:12933">https://doi.org/10.15479/AT:ISTA:12933</a>.'
  ieee: 'G. Puixeu Sala, “Data from: Sex-specific estimation of cis and trans regulation
    of gene expression in heads and gonads of Drosophila melanogaster.” Institute
    of Science and Technology Austria, 2023.'
  ista: 'Puixeu Sala G. 2023. Data from: Sex-specific estimation of cis and trans
    regulation of gene expression in heads and gonads of Drosophila melanogaster,
    Institute of Science and Technology Austria, <a href="https://doi.org/10.15479/AT:ISTA:12933">10.15479/AT:ISTA:12933</a>.'
  mla: 'Puixeu Sala, Gemma. <i>Data from: Sex-Specific Estimation of Cis and Trans
    Regulation of Gene Expression in Heads and Gonads of Drosophila Melanogaster</i>.
    Institute of Science and Technology Austria, 2023, doi:<a href="https://doi.org/10.15479/AT:ISTA:12933">10.15479/AT:ISTA:12933</a>.'
  short: G. Puixeu Sala, (2023).
contributor:
- first_name: Ariana
  id: 2A0848E2-F248-11E8-B48F-1D18A9856A87
  last_name: Macon
- first_name: Beatriz
  id: 49E1C5C6-F248-11E8-B48F-1D18A9856A87
  last_name: Vicoso
  orcid: 0000-0002-4579-8306
date_created: 2023-05-10T10:00:49Z
date_published: 2023-05-15T00:00:00Z
date_updated: 2023-12-13T12:15:36Z
day: '15'
ddc:
- '570'
department:
- _id: GradSch
- _id: NiBa
- _id: BeVi
doi: 10.15479/AT:ISTA:12933
file:
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  checksum: 0ba0bcd0bb8b18d84792136a4370df90
  content_type: text/csv
  creator: gpuixeus
  date_created: 2023-05-10T09:41:43Z
  date_updated: 2023-05-10T09:41:43Z
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  file_size: 8029982
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  date_created: 2023-05-10T09:41:48Z
  date_updated: 2023-05-10T09:41:48Z
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  date_created: 2023-05-10T09:41:50Z
  date_updated: 2023-05-10T09:41:50Z
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  date_created: 2023-05-11T12:50:18Z
  date_updated: 2023-05-11T12:50:18Z
  file_id: '12944'
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  success: 1
file_date_updated: 2023-05-11T12:50:18Z
has_accepted_license: '1'
month: '05'
oa: 1
oa_version: Published Version
publisher: Institute of Science and Technology Austria
related_material:
  record:
  - id: '14058'
    relation: used_in_publication
    status: public
  - id: '14077'
    relation: used_in_publication
    status: public
status: public
title: 'Data from: Sex-specific estimation of cis and trans regulation of gene expression
  in heads and gonads of Drosophila melanogaster'
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: research_data
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2023'
...
---
_id: '6831'
abstract:
- lang: eng
  text: "* Understanding the mechanisms causing phenotypic differences between females
    and males has long fascinated evolutionary biologists. An extensive literature
    exists on animal sexual dimorphism but less information is known about sex differences
    in plants, particularly the extent of geographical variation in sexual dimorphism
    and its life‐cycle dynamics.\r\n* Here, we investigated patterns of genetically
    based sexual dimorphism in vegetative and reproductive traits of a wind‐pollinated
    dioecious plant, Rumex hastatulus, across three life‐cycle stages using open‐pollinated
    families from 30 populations spanning the geographic range and chromosomal variation
    (XY and XY1Y2) of the species.\r\n* The direction and degree of sexual dimorphism
    was highly variable among populations and life‐cycle stages. Sex‐specific differences
    in reproductive function explained a significant amount of temporal change in
    sexual dimorphism. For several traits, geographical variation in sexual dimorphism
    was associated with bioclimatic parameters, likely due to the differential responses
    of the sexes to climate. We found no systematic differences in sexual dimorphism
    between chromosome races.\r\n* Sex‐specific trait differences in dioecious plants
    largely result from a balance between sexual and natural selection on resource
    allocation. Our results indicate that abiotic factors associated with geographical
    context also play a role in modifying sexual dimorphism during the plant life‐cycle."
article_processing_charge: Yes (via OA deal)
article_type: original
author:
- first_name: Gemma
  full_name: Puixeu Sala, Gemma
  id: 33AB266C-F248-11E8-B48F-1D18A9856A87
  last_name: Puixeu Sala
  orcid: 0000-0001-8330-1754
- first_name: Melinda
  full_name: Pickup, Melinda
  id: 2C78037E-F248-11E8-B48F-1D18A9856A87
  last_name: Pickup
  orcid: 0000-0001-6118-0541
- first_name: David
  full_name: Field, David
  last_name: Field
  orcid: 0000-0002-4014-8478
- first_name: Spencer C.H.
  full_name: Barrett, Spencer C.H.
  last_name: Barrett
citation:
  ama: 'Puixeu Sala G, Pickup M, Field D, Barrett SCH. Variation in sexual dimorphism
    in a wind-pollinated plant: The influence of geographical context and life-cycle
    dynamics. <i>New Phytologist</i>. 2019;224(3):1108-1120. doi:<a href="https://doi.org/10.1111/nph.16050">10.1111/nph.16050</a>'
  apa: 'Puixeu Sala, G., Pickup, M., Field, D., &#38; Barrett, S. C. H. (2019). Variation
    in sexual dimorphism in a wind-pollinated plant: The influence of geographical
    context and life-cycle dynamics. <i>New Phytologist</i>. Wiley. <a href="https://doi.org/10.1111/nph.16050">https://doi.org/10.1111/nph.16050</a>'
  chicago: 'Puixeu Sala, Gemma, Melinda Pickup, David Field, and Spencer C.H. Barrett.
    “Variation in Sexual Dimorphism in a Wind-Pollinated Plant: The Influence of Geographical
    Context and Life-Cycle Dynamics.” <i>New Phytologist</i>. Wiley, 2019. <a href="https://doi.org/10.1111/nph.16050">https://doi.org/10.1111/nph.16050</a>.'
  ieee: 'G. Puixeu Sala, M. Pickup, D. Field, and S. C. H. Barrett, “Variation in
    sexual dimorphism in a wind-pollinated plant: The influence of geographical context
    and life-cycle dynamics,” <i>New Phytologist</i>, vol. 224, no. 3. Wiley, pp.
    1108–1120, 2019.'
  ista: 'Puixeu Sala G, Pickup M, Field D, Barrett SCH. 2019. Variation in sexual
    dimorphism in a wind-pollinated plant: The influence of geographical context and
    life-cycle dynamics. New Phytologist. 224(3), 1108–1120.'
  mla: 'Puixeu Sala, Gemma, et al. “Variation in Sexual Dimorphism in a Wind-Pollinated
    Plant: The Influence of Geographical Context and Life-Cycle Dynamics.” <i>New
    Phytologist</i>, vol. 224, no. 3, Wiley, 2019, pp. 1108–20, doi:<a href="https://doi.org/10.1111/nph.16050">10.1111/nph.16050</a>.'
  short: G. Puixeu Sala, M. Pickup, D. Field, S.C.H. Barrett, New Phytologist 224
    (2019) 1108–1120.
date_created: 2019-08-25T22:00:51Z
date_published: 2019-11-01T00:00:00Z
date_updated: 2023-08-29T07:17:07Z
day: '01'
ddc:
- '570'
department:
- _id: NiBa
- _id: BeVi
doi: 10.1111/nph.16050
ec_funded: 1
external_id:
  isi:
  - '000481376500001'
file:
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  date_created: 2019-08-27T12:44:54Z
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  file_id: '6833'
  file_name: 2019_NewPhytologist_Puixeu.pdf
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file_date_updated: 2020-07-14T12:47:42Z
has_accepted_license: '1'
intvolume: '       224'
isi: 1
issue: '3'
language:
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month: '11'
oa: 1
oa_version: Published Version
page: 1108-1120
project:
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  call_identifier: H2020
  grant_number: '665385'
  name: International IST Doctoral Program
publication: New Phytologist
publication_identifier:
  eissn:
  - 1469-8137
publication_status: published
publisher: Wiley
quality_controlled: '1'
related_material:
  record:
  - id: '9803'
    relation: research_data
    status: public
  - id: '14058'
    relation: dissertation_contains
    status: public
scopus_import: '1'
status: public
title: 'Variation in sexual dimorphism in a wind-pollinated plant: The influence of
  geographical context and life-cycle dynamics'
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 224
year: '2019'
...
---
_id: '6089'
abstract:
- lang: eng
  text: Pleiotropy is the well-established idea that a single mutation affects multiple
    phenotypes. If a mutation has opposite effects on fitness when expressed in different
    contexts, then genetic conflict arises. Pleiotropic conflict is expected to reduce
    the efficacy of selection by limiting the fixation of beneficial mutations through
    adaptation, and the removal of deleterious mutations through purifying selection.
    Although this has been widely discussed, in particular in the context of a putative
    “gender load,” it has yet to be systematically quantified. In this work, we empirically
    estimate to which extent different pleiotropic regimes impede the efficacy of
    selection in Drosophila melanogaster. We use whole-genome polymorphism data from
    a single African population and divergence data from D. simulans to estimate the
    fraction of adaptive fixations (α), the rate of adaptation (ωA), and the direction
    of selection (DoS). After controlling for confounding covariates, we find that
    the different pleiotropic regimes have a relatively small, but significant, effect
    on selection efficacy. Specifically, our results suggest that pleiotropic sexual
    antagonism may restrict the efficacy of selection, but that this conflict can
    be resolved by limiting the expression of genes to the sex where they are beneficial.
    Intermediate levels of pleiotropy across tissues and life stages can also lead
    to maladaptation in D. melanogaster, due to inefficient purifying selection combined
    with low frequency of mutations that confer a selective advantage. Thus, our study
    highlights the need to consider the efficacy of selection in the context of antagonistic
    pleiotropy, and of genetic conflict in general.
article_processing_charge: No
author:
- first_name: Christelle
  full_name: Fraisse, Christelle
  id: 32DF5794-F248-11E8-B48F-1D18A9856A87
  last_name: Fraisse
  orcid: 0000-0001-8441-5075
- first_name: Gemma
  full_name: Puixeu Sala, Gemma
  id: 33AB266C-F248-11E8-B48F-1D18A9856A87
  last_name: Puixeu Sala
  orcid: 0000-0001-8330-1754
- first_name: Beatriz
  full_name: Vicoso, Beatriz
  id: 49E1C5C6-F248-11E8-B48F-1D18A9856A87
  last_name: Vicoso
  orcid: 0000-0002-4579-8306
citation:
  ama: Fraisse C, Puixeu Sala G, Vicoso B. Pleiotropy modulates the efficacy of selection
    in drosophila melanogaster. <i>Molecular biology and evolution</i>. 2019;36(3):500-515.
    doi:<a href="https://doi.org/10.1093/molbev/msy246">10.1093/molbev/msy246</a>
  apa: Fraisse, C., Puixeu Sala, G., &#38; Vicoso, B. (2019). Pleiotropy modulates
    the efficacy of selection in drosophila melanogaster. <i>Molecular Biology and
    Evolution</i>. Oxford University Press. <a href="https://doi.org/10.1093/molbev/msy246">https://doi.org/10.1093/molbev/msy246</a>
  chicago: Fraisse, Christelle, Gemma Puixeu Sala, and Beatriz Vicoso. “Pleiotropy
    Modulates the Efficacy of Selection in Drosophila Melanogaster.” <i>Molecular
    Biology and Evolution</i>. Oxford University Press, 2019. <a href="https://doi.org/10.1093/molbev/msy246">https://doi.org/10.1093/molbev/msy246</a>.
  ieee: C. Fraisse, G. Puixeu Sala, and B. Vicoso, “Pleiotropy modulates the efficacy
    of selection in drosophila melanogaster,” <i>Molecular biology and evolution</i>,
    vol. 36, no. 3. Oxford University Press, pp. 500–515, 2019.
  ista: Fraisse C, Puixeu Sala G, Vicoso B. 2019. Pleiotropy modulates the efficacy
    of selection in drosophila melanogaster. Molecular biology and evolution. 36(3),
    500–515.
  mla: Fraisse, Christelle, et al. “Pleiotropy Modulates the Efficacy of Selection
    in Drosophila Melanogaster.” <i>Molecular Biology and Evolution</i>, vol. 36,
    no. 3, Oxford University Press, 2019, pp. 500–15, doi:<a href="https://doi.org/10.1093/molbev/msy246">10.1093/molbev/msy246</a>.
  short: C. Fraisse, G. Puixeu Sala, B. Vicoso, Molecular Biology and Evolution 36
    (2019) 500–515.
date_created: 2019-03-10T22:59:19Z
date_published: 2019-03-01T00:00:00Z
date_updated: 2024-02-21T13:59:17Z
day: '01'
department:
- _id: BeVi
- _id: NiBa
doi: 10.1093/molbev/msy246
external_id:
  isi:
  - '000462585100006'
  pmid:
  - '30590559'
intvolume: '        36'
isi: 1
issue: '3'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://www.ncbi.nlm.nih.gov/pubmed/30590559
month: '03'
oa: 1
oa_version: Submitted Version
page: 500-515
pmid: 1
project:
- _id: 250ED89C-B435-11E9-9278-68D0E5697425
  call_identifier: FWF
  grant_number: P28842-B22
  name: Sex chromosome evolution under male- and female- heterogamety
publication: Molecular biology and evolution
publication_identifier:
  eissn:
  - 1537-1719
  issn:
  - 0737-4038
publication_status: published
publisher: Oxford University Press
quality_controlled: '1'
related_material:
  record:
  - id: '5757'
    relation: popular_science
    status: public
scopus_import: '1'
status: public
title: Pleiotropy modulates the efficacy of selection in drosophila melanogaster
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 36
year: '2019'
...
---
_id: '9803'
abstract:
- lang: eng
  text: Understanding the mechanisms causing phenotypic differences between females
    and males has long fascinated evolutionary biologists. An extensive literature
    exists on animal sexual dimorphism but less is known about sex differences in
    plants, particularly the extent of geographical variation in sexual dimorphism
    and its life-cycle dynamics. Here, we investigate patterns of genetically-based
    sexual dimorphism in vegetative and reproductive traits of a wind-pollinated dioecious
    plant, Rumex hastatulus, across three life-cycle stages using open-pollinated
    families from 30 populations spanning the geographic range and chromosomal variation
    (XY and XY1Y2) of the species. The direction and degree of sexual dimorphism was
    highly variable among populations and life-cycle stages. Sex-specific differences
    in reproductive function explained a significant amount of temporal change in
    sexual dimorphism. For several traits, geographical variation in sexual dimorphism
    was associated with bioclimatic parameters, likely due to the differential responses
    of the sexes to climate. We found no systematic differences in sexual dimorphism
    between chromosome races. Sex-specific trait differences in dioecious plants largely
    result from a balance between sexual and natural selection on resource allocation.
    Our results indicate that abiotic factors associated with geographical context
    also play a role in modifying sexual dimorphism during the plant life cycle.
article_processing_charge: No
author:
- first_name: Gemma
  full_name: Puixeu Sala, Gemma
  id: 33AB266C-F248-11E8-B48F-1D18A9856A87
  last_name: Puixeu Sala
  orcid: 0000-0001-8330-1754
- first_name: Melinda
  full_name: Pickup, Melinda
  id: 2C78037E-F248-11E8-B48F-1D18A9856A87
  last_name: Pickup
  orcid: 0000-0001-6118-0541
- first_name: David
  full_name: Field, David
  last_name: Field
- first_name: Spencer C.H.
  full_name: Barrett, Spencer C.H.
  last_name: Barrett
citation:
  ama: 'Puixeu Sala G, Pickup M, Field D, Barrett SCH. Data from: Variation in sexual
    dimorphism in a wind-pollinated plant: the influence of geographical context and
    life-cycle dynamics. 2019. doi:<a href="https://doi.org/10.5061/dryad.n1701c9">10.5061/dryad.n1701c9</a>'
  apa: 'Puixeu Sala, G., Pickup, M., Field, D., &#38; Barrett, S. C. H. (2019). Data
    from: Variation in sexual dimorphism in a wind-pollinated plant: the influence
    of geographical context and life-cycle dynamics. Dryad. <a href="https://doi.org/10.5061/dryad.n1701c9">https://doi.org/10.5061/dryad.n1701c9</a>'
  chicago: 'Puixeu Sala, Gemma, Melinda Pickup, David Field, and Spencer C.H. Barrett.
    “Data from: Variation in Sexual Dimorphism in a Wind-Pollinated Plant: The Influence
    of Geographical Context and Life-Cycle Dynamics.” Dryad, 2019. <a href="https://doi.org/10.5061/dryad.n1701c9">https://doi.org/10.5061/dryad.n1701c9</a>.'
  ieee: 'G. Puixeu Sala, M. Pickup, D. Field, and S. C. H. Barrett, “Data from: Variation
    in sexual dimorphism in a wind-pollinated plant: the influence of geographical
    context and life-cycle dynamics.” Dryad, 2019.'
  ista: 'Puixeu Sala G, Pickup M, Field D, Barrett SCH. 2019. Data from: Variation
    in sexual dimorphism in a wind-pollinated plant: the influence of geographical
    context and life-cycle dynamics, Dryad, <a href="https://doi.org/10.5061/dryad.n1701c9">10.5061/dryad.n1701c9</a>.'
  mla: 'Puixeu Sala, Gemma, et al. <i>Data from: Variation in Sexual Dimorphism in
    a Wind-Pollinated Plant: The Influence of Geographical Context and Life-Cycle
    Dynamics</i>. Dryad, 2019, doi:<a href="https://doi.org/10.5061/dryad.n1701c9">10.5061/dryad.n1701c9</a>.'
  short: G. Puixeu Sala, M. Pickup, D. Field, S.C.H. Barrett, (2019).
date_created: 2021-08-06T11:48:42Z
date_published: 2019-07-22T00:00:00Z
date_updated: 2023-08-29T07:17:07Z
day: '22'
department:
- _id: NiBa
- _id: BeVi
doi: 10.5061/dryad.n1701c9
main_file_link:
- open_access: '1'
  url: https://doi.org/10.5061/dryad.n1701c9
month: '07'
oa: 1
oa_version: Published Version
publisher: Dryad
related_material:
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  - id: '14058'
    relation: used_in_publication
    status: public
  - id: '6831'
    relation: used_in_publication
    status: public
status: public
title: 'Data from: Variation in sexual dimorphism in a wind-pollinated plant: the
  influence of geographical context and life-cycle dynamics'
type: research_data_reference
user_id: 6785fbc1-c503-11eb-8a32-93094b40e1cf
year: '2019'
...