---
_id: '706'
abstract:
- lang: eng
  text: A hippocampal mossy fiber synapse has a complex structure and is implicated
    in learning and memory. In this synapse, the mossy fiber boutons attach to the
    dendritic shaft by puncta adherentia junctions and wrap around a multiply-branched
    spine, forming synaptic junctions. We have recently shown using transmission electron
    microscopy, immunoelectron microscopy and serial block face-scanning electron
    microscopy that atypical puncta adherentia junctions are formed in the afadin-deficient
    mossy fiber synapse and that the complexity of postsynaptic spines and mossy fiber
    boutons, the number of spine heads, the area of postsynaptic densities and the
    density of synaptic vesicles docked to active zones are decreased in the afadin-deficient
    synapse. We investigated here the roles of afadin in the functional differentiations
    of the mossy fiber synapse using the afadin-deficient mice. The electrophysiological
    studies showed that both the release probability of glutamate and the postsynaptic
    responsiveness to glutamate were markedly reduced, but not completely lost, in
    the afadin-deficient mossy fiber synapse, whereas neither long-term potentiation
    nor long-term depression was affected. These results indicate that afadin plays
    roles in the functional differentiations of the presynapse and the postsynapse
    of the hippocampal mossy fiber synapse.
author:
- first_name: Xiaoqi
  full_name: Geng, Xiaoqi
  id: 3395256A-F248-11E8-B48F-1D18A9856A87
  last_name: Geng
- first_name: Tomohiko
  full_name: Maruo, Tomohiko
  last_name: Maruo
- first_name: Kenji
  full_name: Mandai, Kenji
  last_name: Mandai
- first_name: Irwan
  full_name: Supriyanto, Irwan
  last_name: Supriyanto
- first_name: Muneaki
  full_name: Miyata, Muneaki
  last_name: Miyata
- first_name: Shotaro
  full_name: Sakakibara, Shotaro
  last_name: Sakakibara
- first_name: Akira
  full_name: Mizoguchi, Akira
  last_name: Mizoguchi
- first_name: Yoshimi
  full_name: Takai, Yoshimi
  last_name: Takai
- first_name: Masahiro
  full_name: Mori, Masahiro
  last_name: Mori
citation:
  ama: Geng X, Maruo T, Mandai K, et al. Roles of afadin in functional differentiations
    of hippocampal mossy fiber synapse. <i>Genes to Cells</i>. 2017;22(8):715-722.
    doi:<a href="https://doi.org/10.1111/gtc.12508">10.1111/gtc.12508</a>
  apa: Geng, X., Maruo, T., Mandai, K., Supriyanto, I., Miyata, M., Sakakibara, S.,
    … Mori, M. (2017). Roles of afadin in functional differentiations of hippocampal
    mossy fiber synapse. <i>Genes to Cells</i>. Wiley-Blackwell. <a href="https://doi.org/10.1111/gtc.12508">https://doi.org/10.1111/gtc.12508</a>
  chicago: Geng, Xiaoqi, Tomohiko Maruo, Kenji Mandai, Irwan Supriyanto, Muneaki Miyata,
    Shotaro Sakakibara, Akira Mizoguchi, Yoshimi Takai, and Masahiro Mori. “Roles
    of Afadin in Functional Differentiations of Hippocampal Mossy Fiber Synapse.”
    <i>Genes to Cells</i>. Wiley-Blackwell, 2017. <a href="https://doi.org/10.1111/gtc.12508">https://doi.org/10.1111/gtc.12508</a>.
  ieee: X. Geng <i>et al.</i>, “Roles of afadin in functional differentiations of
    hippocampal mossy fiber synapse,” <i>Genes to Cells</i>, vol. 22, no. 8. Wiley-Blackwell,
    pp. 715–722, 2017.
  ista: Geng X, Maruo T, Mandai K, Supriyanto I, Miyata M, Sakakibara S, Mizoguchi
    A, Takai Y, Mori M. 2017. Roles of afadin in functional differentiations of hippocampal
    mossy fiber synapse. Genes to Cells. 22(8), 715–722.
  mla: Geng, Xiaoqi, et al. “Roles of Afadin in Functional Differentiations of Hippocampal
    Mossy Fiber Synapse.” <i>Genes to Cells</i>, vol. 22, no. 8, Wiley-Blackwell,
    2017, pp. 715–22, doi:<a href="https://doi.org/10.1111/gtc.12508">10.1111/gtc.12508</a>.
  short: X. Geng, T. Maruo, K. Mandai, I. Supriyanto, M. Miyata, S. Sakakibara, A.
    Mizoguchi, Y. Takai, M. Mori, Genes to Cells 22 (2017) 715–722.
date_created: 2018-12-11T11:48:02Z
date_published: 2017-08-01T00:00:00Z
date_updated: 2021-01-12T08:11:37Z
day: '01'
department:
- _id: PeJo
doi: 10.1111/gtc.12508
intvolume: '        22'
issue: '8'
language:
- iso: eng
month: '08'
oa_version: None
page: 715 - 722
publication: Genes to Cells
publication_identifier:
  issn:
  - '13569597'
publication_status: published
publisher: Wiley-Blackwell
publist_id: '6987'
quality_controlled: '1'
scopus_import: 1
status: public
title: Roles of afadin in functional differentiations of hippocampal mossy fiber synapse
type: journal_article
user_id: 3E5EF7F0-F248-11E8-B48F-1D18A9856A87
volume: 22
year: '2017'
...