---
_id: '12826'
abstract:
- lang: eng
  text: "During navigation, animals can infer the structure of the environment by
    computing the optic flow cues elicited by their own movements, and subsequently
    use this information to instruct proper locomotor actions. These computations
    require a panoramic assessment of the visual environment in order to disambiguate
    similar sensory experiences that may require distinct behavioral responses. The
    estimation of the global motion patterns is therefore essential for successful
    navigation. Yet, our understanding of the algorithms and implementations that
    enable coherent panoramic visual perception remains scarce. Here I pursue this
    problem by dissecting the functional aspects of interneuronal communication in
    the lobula plate tangential cell network in Drosophila melanogaster. The results
    presented in the thesis demonstrate that the basis for effective interpretation
    of the optic flow in this circuit are stereotyped synaptic connections that mediate
    the formation of distinct subnetworks, each extracting a particular pattern of
    global motion. \r\nFirstly, I show that gap junctions are essential for a correct
    interpretation of binocular motion cues by horizontal motion-sensitive cells.
    HS cells form electrical synapses with contralateral H2 neurons that are involved
    in detecting yaw rotation and translation. I developed an FlpStop-mediated mutant
    of a gap junction protein ShakB that disrupts these electrical synapses. While
    the loss of electrical synapses does not affect the tuning of the direction selectivity
    in HS neurons, it severely alters their sensitivity to horizontal motion in the
    contralateral side. These physiological changes result in an inappropriate integration
    of binocular motion cues in walking animals. While wild-type flies form a binocular
    perception of visual motion by non-linear integration of monocular optic flow
    cues, the mutant flies sum the monocular inputs linearly. These results indicate
    that rather than averaging signals in neighboring neurons, gap-junctions operate
    in conjunction with chemical synapses to mediate complex non-linear optic flow
    computations.\r\nSecondly, I show that stochastic manipulation of neuronal activity
    in the lobula plate tangential cell network is a powerful approach to study the
    neuronal implementation of optic flow-based navigation in flies. Tangential neurons
    form multiple subnetworks, each mediating course-stabilizing response to a particular
    global pattern of visual motion. Application of genetic mosaic techniques can
    provide sparse optogenetic activation of HS cells in numerous combinations. These
    distinct combinations of activated neurons drive an array of distinct behavioral
    responses, providing important insights into how visuomotor transformation is
    performed in the lobula plate tangential cell network. This approach can be complemented
    by stochastic silencing of tangential neurons, enabling direct assessment of the
    functional role of individual tangential neurons in the processing of specific
    visual motion patterns.\r\n\tTaken together, the findings presented in this thesis
    suggest that establishing specific activity patterns of tangential cells via stereotyped
    synaptic connectivity is a key to efficient optic flow-based navigation in Drosophila
    melanogaster."
acknowledged_ssus:
- _id: Bio
- _id: LifeSc
alternative_title:
- ISTA Thesis
article_processing_charge: No
author:
- first_name: Victoria
  full_name: Pokusaeva, Victoria
  id: 3184041C-F248-11E8-B48F-1D18A9856A87
  last_name: Pokusaeva
  orcid: 0000-0001-7660-444X
citation:
  ama: Pokusaeva V. Neural control of optic flow-based navigation in Drosophila melanogaster.
    2023. doi:<a href="https://doi.org/10.15479/at:ista:12826">10.15479/at:ista:12826</a>
  apa: Pokusaeva, V. (2023). <i>Neural control of optic flow-based navigation in Drosophila
    melanogaster</i>. Institute of Science and Technology Austria. <a href="https://doi.org/10.15479/at:ista:12826">https://doi.org/10.15479/at:ista:12826</a>
  chicago: Pokusaeva, Victoria. “Neural Control of Optic Flow-Based Navigation in
    Drosophila Melanogaster.” Institute of Science and Technology Austria, 2023. <a
    href="https://doi.org/10.15479/at:ista:12826">https://doi.org/10.15479/at:ista:12826</a>.
  ieee: V. Pokusaeva, “Neural control of optic flow-based navigation in Drosophila
    melanogaster,” Institute of Science and Technology Austria, 2023.
  ista: Pokusaeva V. 2023. Neural control of optic flow-based navigation in Drosophila
    melanogaster. Institute of Science and Technology Austria.
  mla: Pokusaeva, Victoria. <i>Neural Control of Optic Flow-Based Navigation in Drosophila
    Melanogaster</i>. Institute of Science and Technology Austria, 2023, doi:<a href="https://doi.org/10.15479/at:ista:12826">10.15479/at:ista:12826</a>.
  short: V. Pokusaeva, Neural Control of Optic Flow-Based Navigation in Drosophila
    Melanogaster, Institute of Science and Technology Austria, 2023.
date_created: 2023-04-14T14:56:04Z
date_published: 2023-04-18T00:00:00Z
date_updated: 2023-06-23T09:47:36Z
day: '18'
ddc:
- '570'
- '571'
degree_awarded: PhD
department:
- _id: MaJö
- _id: GradSch
doi: 10.15479/at:ista:12826
ec_funded: 1
file:
- access_level: closed
  checksum: 5f589a9af025f7eeebfd0c186209913e
  content_type: application/vnd.openxmlformats-officedocument.wordprocessingml.document
  creator: vpokusae
  date_created: 2023-04-20T09:14:38Z
  date_updated: 2023-04-20T09:26:51Z
  file_id: '12857'
  file_name: Thesis_Pokusaeva.docx
  file_size: 14507243
  relation: source_file
- access_level: open_access
  checksum: bbeed76db45a996b4c91a9abe12ce0ec
  content_type: application/pdf
  creator: vpokusae
  date_created: 2023-04-20T09:14:44Z
  date_updated: 2023-04-20T09:14:44Z
  file_id: '12858'
  file_name: Thesis_Pokusaeva.pdf
  file_size: 10090711
  relation: main_file
  success: 1
file_date_updated: 2023-04-20T09:26:51Z
has_accepted_license: '1'
language:
- iso: eng
month: '04'
oa: 1
oa_version: Published Version
page: '106'
project:
- _id: 2564DBCA-B435-11E9-9278-68D0E5697425
  call_identifier: H2020
  grant_number: '665385'
  name: International IST Doctoral Program
publication_identifier:
  issn:
  - 2663 - 337X
publication_status: published
publisher: Institute of Science and Technology Austria
status: public
supervisor:
- first_name: Maximilian A
  full_name: Jösch, Maximilian A
  id: 2BD278E6-F248-11E8-B48F-1D18A9856A87
  last_name: Jösch
  orcid: 0000-0002-3937-1330
title: Neural control of optic flow-based navigation in Drosophila melanogaster
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: dissertation
user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
year: '2023'
...
---
_id: '12226'
abstract:
- lang: eng
  text: "Background: Biases of DNA repair can shape the nucleotide landscape of genomes
    at evolutionary timescales. The molecular mechanisms of those biases are still
    poorly understood because it is difficult to isolate the contributions of DNA
    repair from those of DNA damage.\r\n\r\nResults: Here, we develop a genome-wide
    assay whereby the same DNA lesion is repaired in different genomic contexts. We
    insert thousands of barcoded transposons carrying a reporter of DNA mismatch repair
    in the genome of mouse embryonic stem cells. Upon inducing a double-strand break
    between tandem repeats, a mismatch is generated if the break is repaired through
    single-strand annealing. The resolution of the mismatch showed a 60–80% bias in
    favor of the strand with the longest 3′ flap. The location of the lesion in the
    genome and the type of mismatch had little influence on the bias. Instead, we
    observe a complete reversal of the bias when the longest 3′ flap is moved to the
    opposite strand by changing the position of the double-strand break in the reporter.\r\n\r\nConclusions:
    These results suggest that the processing of the double-strand break has a major
    influence on the repair of mismatches during single-strand annealing."
acknowledgement: We acknowledge the financial support of the Natural Sciences and
  Engineering Research Council of Canada (NSERC RGPIN-2020-06377), the Spanish Ministry
  of Economy, Industry and Competitiveness (“Centro de Excelencia Severo Ochoa 2013-2017”,
  Plan Estatal PGC2018-099807-B-I00), of the CERCA Programme/Generalitat de Catalunya,
  and of the European Research Council (Synergy Grant 609989). VOP was supported by
  the European Union’s Horizon 2020 research and innovation program under the Marie
  Skłodowska-Curie programme (665385). We also acknowledge the support of the Spanish
  Ministry of Economy and Competitiveness (MEIC) to the EMBL partnership.
article_number: '93'
article_processing_charge: No
article_type: original
author:
- first_name: Victoria
  full_name: Pokusaeva, Victoria
  id: 3184041C-F248-11E8-B48F-1D18A9856A87
  last_name: Pokusaeva
  orcid: 0000-0001-7660-444X
- first_name: Aránzazu Rosado
  full_name: Diez, Aránzazu Rosado
  last_name: Diez
- first_name: Lorena
  full_name: Espinar, Lorena
  last_name: Espinar
- first_name: Albert Torelló
  full_name: Pérez, Albert Torelló
  last_name: Pérez
- first_name: Guillaume J.
  full_name: Filion, Guillaume J.
  last_name: Filion
citation:
  ama: Pokusaeva V, Diez AR, Espinar L, Pérez AT, Filion GJ. Strand asymmetry influences
    mismatch resolution during single-strand annealing. <i>Genome Biology</i>. 2022;23.
    doi:<a href="https://doi.org/10.1186/s13059-022-02665-3">10.1186/s13059-022-02665-3</a>
  apa: Pokusaeva, V., Diez, A. R., Espinar, L., Pérez, A. T., &#38; Filion, G. J.
    (2022). Strand asymmetry influences mismatch resolution during single-strand annealing.
    <i>Genome Biology</i>. Springer Nature. <a href="https://doi.org/10.1186/s13059-022-02665-3">https://doi.org/10.1186/s13059-022-02665-3</a>
  chicago: Pokusaeva, Victoria, Aránzazu Rosado Diez, Lorena Espinar, Albert Torelló
    Pérez, and Guillaume J. Filion. “Strand Asymmetry Influences Mismatch Resolution
    during Single-Strand Annealing.” <i>Genome Biology</i>. Springer Nature, 2022.
    <a href="https://doi.org/10.1186/s13059-022-02665-3">https://doi.org/10.1186/s13059-022-02665-3</a>.
  ieee: V. Pokusaeva, A. R. Diez, L. Espinar, A. T. Pérez, and G. J. Filion, “Strand
    asymmetry influences mismatch resolution during single-strand annealing,” <i>Genome
    Biology</i>, vol. 23. Springer Nature, 2022.
  ista: Pokusaeva V, Diez AR, Espinar L, Pérez AT, Filion GJ. 2022. Strand asymmetry
    influences mismatch resolution during single-strand annealing. Genome Biology.
    23, 93.
  mla: Pokusaeva, Victoria, et al. “Strand Asymmetry Influences Mismatch Resolution
    during Single-Strand Annealing.” <i>Genome Biology</i>, vol. 23, 93, Springer
    Nature, 2022, doi:<a href="https://doi.org/10.1186/s13059-022-02665-3">10.1186/s13059-022-02665-3</a>.
  short: V. Pokusaeva, A.R. Diez, L. Espinar, A.T. Pérez, G.J. Filion, Genome Biology
    23 (2022).
date_created: 2023-01-16T09:48:44Z
date_published: 2022-04-12T00:00:00Z
date_updated: 2023-08-04T09:27:00Z
day: '12'
ddc:
- '570'
department:
- _id: MaJö
doi: 10.1186/s13059-022-02665-3
ec_funded: 1
external_id:
  isi:
  - '000781953800001'
  pmid:
  - '35414014'
file:
- access_level: open_access
  checksum: 17bb091fec04d82ba20a3458c4cfd2bd
  content_type: application/pdf
  creator: dernst
  date_created: 2023-01-27T09:01:40Z
  date_updated: 2023-01-27T09:01:40Z
  file_id: '12419'
  file_name: 2022_GenomeBiology_Pokusaeva.pdf
  file_size: 4939342
  relation: main_file
  success: 1
file_date_updated: 2023-01-27T09:01:40Z
has_accepted_license: '1'
intvolume: '        23'
isi: 1
language:
- iso: eng
month: '04'
oa: 1
oa_version: Published Version
pmid: 1
project:
- _id: 2564DBCA-B435-11E9-9278-68D0E5697425
  call_identifier: H2020
  grant_number: '665385'
  name: International IST Doctoral Program
publication: Genome Biology
publication_identifier:
  issn:
  - 1474-760X
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
related_material:
  link:
  - relation: software
    url: 'https://github.com/cellcomplexitylab/strand_asymmetry '
  - relation: software
    url: https://hub.docker.com/r/gui11aume/strand_asymmetry
scopus_import: '1'
status: public
title: Strand asymmetry influences mismatch resolution during single-strand annealing
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 23
year: '2022'
...
---
_id: '6419'
abstract:
- lang: eng
  text: Characterizing the fitness landscape, a representation of fitness for a large
    set of genotypes, is key to understanding how genetic information is interpreted
    to create functional organisms. Here we determined the evolutionarily-relevant
    segment of the fitness landscape of His3, a gene coding for an enzyme in the histidine
    synthesis pathway, focusing on combinations of amino acid states found at orthologous
    sites of extant species. Just 15% of amino acids found in yeast His3 orthologues
    were always neutral while the impact on fitness of the remaining 85% depended
    on the genetic background. Furthermore, at 67% of sites, amino acid replacements
    were under sign epistasis, having both strongly positive and negative effect in
    different genetic backgrounds. 46% of sites were under reciprocal sign epistasis.
    The fitness impact of amino acid replacements was influenced by only a few genetic
    backgrounds but involved interaction of multiple sites, shaping a rugged fitness
    landscape in which many of the shortest paths between highly fit genotypes are
    inaccessible.
article_number: e1008079
article_processing_charge: No
author:
- first_name: Victoria
  full_name: Pokusaeva, Victoria
  id: 3184041C-F248-11E8-B48F-1D18A9856A87
  last_name: Pokusaeva
  orcid: 0000-0001-7660-444X
- first_name: Dinara R.
  full_name: Usmanova, Dinara R.
  last_name: Usmanova
- first_name: Ekaterina V.
  full_name: Putintseva, Ekaterina V.
  last_name: Putintseva
- first_name: Lorena
  full_name: Espinar, Lorena
  last_name: Espinar
- first_name: Karen
  full_name: Sarkisyan, Karen
  id: 39A7BF80-F248-11E8-B48F-1D18A9856A87
  last_name: Sarkisyan
  orcid: 0000-0002-5375-6341
- first_name: Alexander S.
  full_name: Mishin, Alexander S.
  last_name: Mishin
- first_name: Natalya S.
  full_name: Bogatyreva, Natalya S.
  last_name: Bogatyreva
- first_name: Dmitry
  full_name: Ivankov, Dmitry
  id: 49FF1036-F248-11E8-B48F-1D18A9856A87
  last_name: Ivankov
- first_name: Arseniy
  full_name: Akopyan, Arseniy
  id: 430D2C90-F248-11E8-B48F-1D18A9856A87
  last_name: Akopyan
  orcid: 0000-0002-2548-617X
- first_name: Sergey
  full_name: Avvakumov, Sergey
  id: 3827DAC8-F248-11E8-B48F-1D18A9856A87
  last_name: Avvakumov
- first_name: Inna S.
  full_name: Povolotskaya, Inna S.
  last_name: Povolotskaya
- first_name: Guillaume J.
  full_name: Filion, Guillaume J.
  last_name: Filion
- first_name: Lucas B.
  full_name: Carey, Lucas B.
  last_name: Carey
- first_name: Fyodor
  full_name: Kondrashov, Fyodor
  id: 44FDEF62-F248-11E8-B48F-1D18A9856A87
  last_name: Kondrashov
  orcid: 0000-0001-8243-4694
citation:
  ama: Pokusaeva V, Usmanova DR, Putintseva EV, et al. An experimental assay of the
    interactions of amino acids from orthologous sequences shaping a complex fitness
    landscape. <i>PLoS Genetics</i>. 2019;15(4). doi:<a href="https://doi.org/10.1371/journal.pgen.1008079">10.1371/journal.pgen.1008079</a>
  apa: Pokusaeva, V., Usmanova, D. R., Putintseva, E. V., Espinar, L., Sarkisyan,
    K., Mishin, A. S., … Kondrashov, F. (2019). An experimental assay of the interactions
    of amino acids from orthologous sequences shaping a complex fitness landscape.
    <i>PLoS Genetics</i>. Public Library of Science. <a href="https://doi.org/10.1371/journal.pgen.1008079">https://doi.org/10.1371/journal.pgen.1008079</a>
  chicago: Pokusaeva, Victoria, Dinara R. Usmanova, Ekaterina V. Putintseva, Lorena
    Espinar, Karen Sarkisyan, Alexander S. Mishin, Natalya S. Bogatyreva, et al. “An
    Experimental Assay of the Interactions of Amino Acids from Orthologous Sequences
    Shaping a Complex Fitness Landscape.” <i>PLoS Genetics</i>. Public Library of
    Science, 2019. <a href="https://doi.org/10.1371/journal.pgen.1008079">https://doi.org/10.1371/journal.pgen.1008079</a>.
  ieee: V. Pokusaeva <i>et al.</i>, “An experimental assay of the interactions of
    amino acids from orthologous sequences shaping a complex fitness landscape,” <i>PLoS
    Genetics</i>, vol. 15, no. 4. Public Library of Science, 2019.
  ista: Pokusaeva V, Usmanova DR, Putintseva EV, Espinar L, Sarkisyan K, Mishin AS,
    Bogatyreva NS, Ivankov D, Akopyan A, Avvakumov S, Povolotskaya IS, Filion GJ,
    Carey LB, Kondrashov F. 2019. An experimental assay of the interactions of amino
    acids from orthologous sequences shaping a complex fitness landscape. PLoS Genetics.
    15(4), e1008079.
  mla: Pokusaeva, Victoria, et al. “An Experimental Assay of the Interactions of Amino
    Acids from Orthologous Sequences Shaping a Complex Fitness Landscape.” <i>PLoS
    Genetics</i>, vol. 15, no. 4, e1008079, Public Library of Science, 2019, doi:<a
    href="https://doi.org/10.1371/journal.pgen.1008079">10.1371/journal.pgen.1008079</a>.
  short: V. Pokusaeva, D.R. Usmanova, E.V. Putintseva, L. Espinar, K. Sarkisyan, A.S.
    Mishin, N.S. Bogatyreva, D. Ivankov, A. Akopyan, S. Avvakumov, I.S. Povolotskaya,
    G.J. Filion, L.B. Carey, F. Kondrashov, PLoS Genetics 15 (2019).
date_created: 2019-05-13T07:58:38Z
date_published: 2019-04-10T00:00:00Z
date_updated: 2023-08-25T10:30:37Z
day: '10'
ddc:
- '570'
department:
- _id: FyKo
doi: 10.1371/journal.pgen.1008079
ec_funded: 1
external_id:
  isi:
  - '000466866000029'
file:
- access_level: open_access
  checksum: cf3889c8a8a16053dacf9c3776cbe217
  content_type: application/pdf
  creator: dernst
  date_created: 2019-05-14T08:26:08Z
  date_updated: 2020-07-14T12:47:30Z
  file_id: '6445'
  file_name: 2019_PLOSGenetics_Pokusaeva.pdf
  file_size: 3726017
  relation: main_file
file_date_updated: 2020-07-14T12:47:30Z
has_accepted_license: '1'
intvolume: '        15'
isi: 1
issue: '4'
language:
- iso: eng
month: '04'
oa: 1
oa_version: Published Version
project:
- _id: 2564DBCA-B435-11E9-9278-68D0E5697425
  call_identifier: H2020
  grant_number: '665385'
  name: International IST Doctoral Program
publication: PLoS Genetics
publication_identifier:
  eissn:
  - '15537404'
publication_status: published
publisher: Public Library of Science
quality_controlled: '1'
related_material:
  record:
  - id: '9789'
    relation: research_data
    status: public
  - id: '9790'
    relation: research_data
    status: public
  - id: '9797'
    relation: research_data
    status: public
scopus_import: '1'
status: public
title: An experimental assay of the interactions of amino acids from orthologous sequences
  shaping a complex fitness landscape
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 15
year: '2019'
...
---
_id: '9789'
article_processing_charge: No
author:
- first_name: Victoria
  full_name: Pokusaeva, Victoria
  id: 3184041C-F248-11E8-B48F-1D18A9856A87
  last_name: Pokusaeva
  orcid: 0000-0001-7660-444X
- first_name: Dinara R.
  full_name: Usmanova, Dinara R.
  last_name: Usmanova
- first_name: Ekaterina V.
  full_name: Putintseva, Ekaterina V.
  last_name: Putintseva
- first_name: Lorena
  full_name: Espinar, Lorena
  last_name: Espinar
- first_name: Karen
  full_name: Sarkisyan, Karen
  id: 39A7BF80-F248-11E8-B48F-1D18A9856A87
  last_name: Sarkisyan
  orcid: 0000-0002-5375-6341
- first_name: Alexander S.
  full_name: Mishin, Alexander S.
  last_name: Mishin
- first_name: Natalya S.
  full_name: Bogatyreva, Natalya S.
  last_name: Bogatyreva
- first_name: Dmitry
  full_name: Ivankov, Dmitry
  id: 49FF1036-F248-11E8-B48F-1D18A9856A87
  last_name: Ivankov
- first_name: Arseniy
  full_name: Akopyan, Arseniy
  id: 430D2C90-F248-11E8-B48F-1D18A9856A87
  last_name: Akopyan
  orcid: 0000-0002-2548-617X
- first_name: Sergey
  full_name: Avvakumov, Sergey
  id: 3827DAC8-F248-11E8-B48F-1D18A9856A87
  last_name: Avvakumov
- first_name: Inna S.
  full_name: Povolotskaya, Inna S.
  last_name: Povolotskaya
- first_name: Guillaume J.
  full_name: Filion, Guillaume J.
  last_name: Filion
- first_name: Lucas B.
  full_name: Carey, Lucas B.
  last_name: Carey
- first_name: Fyodor
  full_name: Kondrashov, Fyodor
  id: 44FDEF62-F248-11E8-B48F-1D18A9856A87
  last_name: Kondrashov
  orcid: 0000-0001-8243-4694
citation:
  ama: Pokusaeva V, Usmanova DR, Putintseva EV, et al. Multiple alignment of His3
    orthologues. 2019. doi:<a href="https://doi.org/10.1371/journal.pgen.1008079.s010">10.1371/journal.pgen.1008079.s010</a>
  apa: Pokusaeva, V., Usmanova, D. R., Putintseva, E. V., Espinar, L., Sarkisyan,
    K., Mishin, A. S., … Kondrashov, F. (2019). Multiple alignment of His3 orthologues.
    Public Library of Science. <a href="https://doi.org/10.1371/journal.pgen.1008079.s010">https://doi.org/10.1371/journal.pgen.1008079.s010</a>
  chicago: Pokusaeva, Victoria, Dinara R. Usmanova, Ekaterina V. Putintseva, Lorena
    Espinar, Karen Sarkisyan, Alexander S. Mishin, Natalya S. Bogatyreva, et al. “Multiple
    Alignment of His3 Orthologues.” Public Library of Science, 2019. <a href="https://doi.org/10.1371/journal.pgen.1008079.s010">https://doi.org/10.1371/journal.pgen.1008079.s010</a>.
  ieee: V. Pokusaeva <i>et al.</i>, “Multiple alignment of His3 orthologues.” Public
    Library of Science, 2019.
  ista: Pokusaeva V, Usmanova DR, Putintseva EV, Espinar L, Sarkisyan K, Mishin AS,
    Bogatyreva NS, Ivankov D, Akopyan A, Avvakumov S, Povolotskaya IS, Filion GJ,
    Carey LB, Kondrashov F. 2019. Multiple alignment of His3 orthologues, Public Library
    of Science, <a href="https://doi.org/10.1371/journal.pgen.1008079.s010">10.1371/journal.pgen.1008079.s010</a>.
  mla: Pokusaeva, Victoria, et al. <i>Multiple Alignment of His3 Orthologues</i>.
    Public Library of Science, 2019, doi:<a href="https://doi.org/10.1371/journal.pgen.1008079.s010">10.1371/journal.pgen.1008079.s010</a>.
  short: V. Pokusaeva, D.R. Usmanova, E.V. Putintseva, L. Espinar, K. Sarkisyan, A.S.
    Mishin, N.S. Bogatyreva, D. Ivankov, A. Akopyan, S. Avvakumov, I.S. Povolotskaya,
    G.J. Filion, L.B. Carey, F. Kondrashov, (2019).
date_created: 2021-08-06T08:38:50Z
date_published: 2019-04-10T00:00:00Z
date_updated: 2023-08-25T10:30:36Z
day: '10'
department:
- _id: FyKo
doi: 10.1371/journal.pgen.1008079.s010
month: '04'
oa_version: Published Version
publisher: Public Library of Science
related_material:
  record:
  - id: '6419'
    relation: used_in_publication
    status: public
status: public
title: Multiple alignment of His3 orthologues
type: research_data_reference
user_id: 6785fbc1-c503-11eb-8a32-93094b40e1cf
year: '2019'
...
---
_id: '9790'
article_processing_charge: No
author:
- first_name: Victoria
  full_name: Pokusaeva, Victoria
  id: 3184041C-F248-11E8-B48F-1D18A9856A87
  last_name: Pokusaeva
  orcid: 0000-0001-7660-444X
- first_name: Dinara R.
  full_name: Usmanova, Dinara R.
  last_name: Usmanova
- first_name: Ekaterina V.
  full_name: Putintseva, Ekaterina V.
  last_name: Putintseva
- first_name: Lorena
  full_name: Espinar, Lorena
  last_name: Espinar
- first_name: Karen
  full_name: Sarkisyan, Karen
  id: 39A7BF80-F248-11E8-B48F-1D18A9856A87
  last_name: Sarkisyan
  orcid: 0000-0002-5375-6341
- first_name: Alexander S.
  full_name: Mishin, Alexander S.
  last_name: Mishin
- first_name: Natalya S.
  full_name: Bogatyreva, Natalya S.
  last_name: Bogatyreva
- first_name: Dmitry
  full_name: Ivankov, Dmitry
  id: 49FF1036-F248-11E8-B48F-1D18A9856A87
  last_name: Ivankov
- first_name: Arseniy
  full_name: Akopyan, Arseniy
  id: 430D2C90-F248-11E8-B48F-1D18A9856A87
  last_name: Akopyan
  orcid: 0000-0002-2548-617X
- first_name: Sergey
  full_name: Avvakumov, Sergey
  id: 3827DAC8-F248-11E8-B48F-1D18A9856A87
  last_name: Avvakumov
- first_name: Inna S.
  full_name: Povolotskaya, Inna S.
  last_name: Povolotskaya
- first_name: Guillaume J.
  full_name: Filion, Guillaume J.
  last_name: Filion
- first_name: Lucas B.
  full_name: Carey, Lucas B.
  last_name: Carey
- first_name: Fyodor
  full_name: Kondrashov, Fyodor
  id: 44FDEF62-F248-11E8-B48F-1D18A9856A87
  last_name: Kondrashov
  orcid: 0000-0001-8243-4694
citation:
  ama: Pokusaeva V, Usmanova DR, Putintseva EV, et al. A statistical summary of segment
    libraries and sequencing results. 2019. doi:<a href="https://doi.org/10.1371/journal.pgen.1008079.s011">10.1371/journal.pgen.1008079.s011</a>
  apa: Pokusaeva, V., Usmanova, D. R., Putintseva, E. V., Espinar, L., Sarkisyan,
    K., Mishin, A. S., … Kondrashov, F. (2019). A statistical summary of segment libraries
    and sequencing results. Public Library of Science. <a href="https://doi.org/10.1371/journal.pgen.1008079.s011">https://doi.org/10.1371/journal.pgen.1008079.s011</a>
  chicago: Pokusaeva, Victoria, Dinara R. Usmanova, Ekaterina V. Putintseva, Lorena
    Espinar, Karen Sarkisyan, Alexander S. Mishin, Natalya S. Bogatyreva, et al. “A
    Statistical Summary of Segment Libraries and Sequencing Results.” Public Library
    of Science, 2019. <a href="https://doi.org/10.1371/journal.pgen.1008079.s011">https://doi.org/10.1371/journal.pgen.1008079.s011</a>.
  ieee: V. Pokusaeva <i>et al.</i>, “A statistical summary of segment libraries and
    sequencing results.” Public Library of Science, 2019.
  ista: Pokusaeva V, Usmanova DR, Putintseva EV, Espinar L, Sarkisyan K, Mishin AS,
    Bogatyreva NS, Ivankov D, Akopyan A, Avvakumov S, Povolotskaya IS, Filion GJ,
    Carey LB, Kondrashov F. 2019. A statistical summary of segment libraries and sequencing
    results, Public Library of Science, <a href="https://doi.org/10.1371/journal.pgen.1008079.s011">10.1371/journal.pgen.1008079.s011</a>.
  mla: Pokusaeva, Victoria, et al. <i>A Statistical Summary of Segment Libraries and
    Sequencing Results</i>. Public Library of Science, 2019, doi:<a href="https://doi.org/10.1371/journal.pgen.1008079.s011">10.1371/journal.pgen.1008079.s011</a>.
  short: V. Pokusaeva, D.R. Usmanova, E.V. Putintseva, L. Espinar, K. Sarkisyan, A.S.
    Mishin, N.S. Bogatyreva, D. Ivankov, A. Akopyan, S. Avvakumov, I.S. Povolotskaya,
    G.J. Filion, L.B. Carey, F. Kondrashov, (2019).
date_created: 2021-08-06T08:50:15Z
date_published: 2019-04-10T00:00:00Z
date_updated: 2023-08-25T10:30:36Z
day: '10'
department:
- _id: FyKo
doi: 10.1371/journal.pgen.1008079.s011
month: '04'
oa_version: Published Version
publisher: Public Library of Science
related_material:
  record:
  - id: '6419'
    relation: used_in_publication
    status: public
status: public
title: A statistical summary of segment libraries and sequencing results
type: research_data_reference
user_id: 6785fbc1-c503-11eb-8a32-93094b40e1cf
year: '2019'
...
---
_id: '9797'
article_processing_charge: No
author:
- first_name: Victoria
  full_name: Pokusaeva, Victoria
  id: 3184041C-F248-11E8-B48F-1D18A9856A87
  last_name: Pokusaeva
  orcid: 0000-0001-7660-444X
- first_name: Dinara R.
  full_name: Usmanova, Dinara R.
  last_name: Usmanova
- first_name: Ekaterina V.
  full_name: Putintseva, Ekaterina V.
  last_name: Putintseva
- first_name: Lorena
  full_name: Espinar, Lorena
  last_name: Espinar
- first_name: Karen
  full_name: Sarkisyan, Karen
  id: 39A7BF80-F248-11E8-B48F-1D18A9856A87
  last_name: Sarkisyan
  orcid: 0000-0002-5375-6341
- first_name: Alexander S.
  full_name: Mishin, Alexander S.
  last_name: Mishin
- first_name: Natalya S.
  full_name: Bogatyreva, Natalya S.
  last_name: Bogatyreva
- first_name: Dmitry
  full_name: Ivankov, Dmitry
  id: 49FF1036-F248-11E8-B48F-1D18A9856A87
  last_name: Ivankov
- first_name: Arseniy
  full_name: Akopyan, Arseniy
  id: 430D2C90-F248-11E8-B48F-1D18A9856A87
  last_name: Akopyan
  orcid: 0000-0002-2548-617X
- first_name: Inna S.
  full_name: Povolotskaya, Inna S.
  last_name: Povolotskaya
- first_name: Guillaume J.
  full_name: Filion, Guillaume J.
  last_name: Filion
- first_name: Lucas B.
  full_name: Carey, Lucas B.
  last_name: Carey
- first_name: Fyodor
  full_name: Kondrashov, Fyodor
  id: 44FDEF62-F248-11E8-B48F-1D18A9856A87
  last_name: Kondrashov
  orcid: 0000-0001-8243-4694
citation:
  ama: Pokusaeva V, Usmanova DR, Putintseva EV, et al. A statistical summary of segment
    libraries and sequencing results. 2019. doi:<a href="https://doi.org/10.1371/journal.pgen.1008079.s011">10.1371/journal.pgen.1008079.s011</a>
  apa: Pokusaeva, V., Usmanova, D. R., Putintseva, E. V., Espinar, L., Sarkisyan,
    K., Mishin, A. S., … Kondrashov, F. (2019). A statistical summary of segment libraries
    and sequencing results. Public Library of Science. <a href="https://doi.org/10.1371/journal.pgen.1008079.s011">https://doi.org/10.1371/journal.pgen.1008079.s011</a>
  chicago: Pokusaeva, Victoria, Dinara R. Usmanova, Ekaterina V. Putintseva, Lorena
    Espinar, Karen Sarkisyan, Alexander S. Mishin, Natalya S. Bogatyreva, et al. “A
    Statistical Summary of Segment Libraries and Sequencing Results.” Public Library
    of Science, 2019. <a href="https://doi.org/10.1371/journal.pgen.1008079.s011">https://doi.org/10.1371/journal.pgen.1008079.s011</a>.
  ieee: V. Pokusaeva <i>et al.</i>, “A statistical summary of segment libraries and
    sequencing results.” Public Library of Science, 2019.
  ista: Pokusaeva V, Usmanova DR, Putintseva EV, Espinar L, Sarkisyan K, Mishin AS,
    Bogatyreva NS, Ivankov D, Akopyan A, Povolotskaya IS, Filion GJ, Carey LB, Kondrashov
    F. 2019. A statistical summary of segment libraries and sequencing results, Public
    Library of Science, <a href="https://doi.org/10.1371/journal.pgen.1008079.s011">10.1371/journal.pgen.1008079.s011</a>.
  mla: Pokusaeva, Victoria, et al. <i>A Statistical Summary of Segment Libraries and
    Sequencing Results</i>. Public Library of Science, 2019, doi:<a href="https://doi.org/10.1371/journal.pgen.1008079.s011">10.1371/journal.pgen.1008079.s011</a>.
  short: V. Pokusaeva, D.R. Usmanova, E.V. Putintseva, L. Espinar, K. Sarkisyan, A.S.
    Mishin, N.S. Bogatyreva, D. Ivankov, A. Akopyan, I.S. Povolotskaya, G.J. Filion,
    L.B. Carey, F. Kondrashov, (2019).
date_created: 2021-08-06T11:08:20Z
date_published: 2019-04-10T00:00:00Z
date_updated: 2023-08-25T10:30:36Z
day: '10'
department:
- _id: FyKo
doi: 10.1371/journal.pgen.1008079.s011
month: '04'
oa_version: Published Version
publisher: Public Library of Science
related_material:
  record:
  - id: '6419'
    relation: used_in_publication
    status: public
status: public
title: A statistical summary of segment libraries and sequencing results
type: research_data_reference
user_id: 6785fbc1-c503-11eb-8a32-93094b40e1cf
year: '2019'
...